AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth CareGeographicals
HypophosphatemiaNeoplasms, Connective TissueHypophosphatemia, FamilialRicketsMesenchymomaHydroxycholecalciferolsHemangiopericytomaParaneoplastic SyndromesFamilial Hypophosphatemic RicketsFanconi SyndromeBone and BonesAluminumPhosphatesRenal OsteodystrophyOsteitis Fibrosa CysticaVitamin DHypophosphatasiaPhosphorusAlkaline PhosphataseIliumVitamin D DeficiencyFibroblast Growth FactorsDihydroxycholecalciferolsPrimidoneCalcification, PhysiologicGlucaric AcidErgocalciferolsBone DiseasesHyperparathyroidismPHEX Phosphate Regulating Neutral EndopeptidaseFibrous Dysplasia of BoneCalcitriolAcidosis, Renal TubularFemoral Neck FracturesPhenytoinGenetic Diseases, X-LinkedParathyroid HormoneStrontiumLymphangiectasis, IntestinalHypocalcemiaFractures, SpontaneousCholecalciferolSunlightBone Diseases, MetabolicCalcifediolCalciumChondromaHyperparathyroidism, SecondaryOsteoporosisSodium-Phosphate Cotransporter Proteins, Type IIcGastrectomyMandibular FracturesGlutethimideBone MatrixMandibular NeoplasmsAnemia, RefractoryBisphosphonate-Associated Osteonecrosis of the JawCalcium Metabolism DisordersMaxillary DiseasesWhole Body ImagingMineralsMalabsorption SyndromesPurpura, HyperglobulinemicOsteocytesMuscular DiseasesMandibular DiseasesIatrogenic DiseaseBone DensityRenal DialysisBone NeoplasmsParathyroid GlandsBone RemodelingUremiaBone Density Conservation AgentsCeliac DiseaseAnticonvulsantsParathyroid NeoplasmsLiver Cirrhosis, BiliaryOsteoblastsSoft Tissue NeoplasmsIntestinal AbsorptionKidneyCalcium, DietaryPhenobarbitalTibiaFerric CompoundsEpilepsyFemurKidney Failure, ChronicOsteomalaciaSaudi ArabiaExtracellular Matrix ProteinsBiopsyKidney DiseasesCreatinineDietTime FactorsMice, KnockoutRetrospective StudiesRisk Factors
Hypophosphatemia
A condition of an abnormally low level of PHOSPHATES in the blood.
Neoplasms, Connective Tissue
Neoplasms composed of connective tissue, including elastic, mucous, reticular, osseous, and cartilaginous tissue. The concept does not refer to neoplasms located in connective tissue.
Hypophosphatemia, Familial
An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.
Rickets
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Mesenchymoma
A mixed mesenchymal tumor composed of two or more mesodermal cellular elements not commonly associated, not counting fibrous tissue as one of the elements. Mesenchymomas are widely distributed in the body and about 75% are malignant. (Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
Hydroxycholecalciferols
Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.
Hemangiopericytoma
A tumor composed of spindle cells with a rich vascular network, which apparently arises from pericytes, cells of smooth muscle origin that lie around small vessels. Benign and malignant hemangiopericytomas exist, and the rarity of these lesions has led to considerable confusion in distinguishing between benign and malignant variants. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1364)
Paraneoplastic Syndromes
In patients with neoplastic diseases a wide variety of clinical pictures which are indirect and usually remote effects produced by tumor cell metabolites or other products.
Familial Hypophosphatemic Rickets
A hereditary disorder characterized by HYPOPHOSPHATEMIA; RICKETS; OSTEOMALACIA; renal defects in phosphate reabsorption and vitamin D metabolism; and growth retardation. Autosomal and X-linked dominant and recessive variants have been reported.
Fanconi Syndrome
A hereditary or acquired form of generalized dysfunction of the PROXIMAL KIDNEY TUBULE without primary involvement of the KIDNEY GLOMERULUS. It is usually characterized by the tubular wasting of nutrients and salts (GLUCOSE; AMINO ACIDS; PHOSPHATES; and BICARBONATES) resulting in HYPOKALEMIA; ACIDOSIS; HYPERCALCIURIA; and PROTEINURIA.
Bone and Bones
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Aluminum
A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.
Phosphates
Inorganic salts of phosphoric acid.
Renal Osteodystrophy
Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.
Osteitis Fibrosa Cystica
A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.
Vitamin D
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
Hypophosphatasia
A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
Phosphorus
A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.
Alkaline Phosphatase
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
Ilium
The largest of three bones that make up each half of the pelvic girdle.
Vitamin D Deficiency
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Fibroblast Growth Factors
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
Dihydroxycholecalciferols
Cholecalciferols substituted with two hydroxy groups in any position.
Primidone
An antiepileptic agent related to the barbiturates; it is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with PHENOBARBITAL. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309)
Calcification, Physiologic
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
Glucaric Acid
A sugar acid derived from D-glucose in which both the aldehydic carbon atom and the carbon atom bearing the primary hydroxyl group are oxidized to carboxylic acid groups.
Ergocalciferols
Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.
Bone Diseases
Diseases of BONES.
Hyperparathyroidism
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
PHEX Phosphate Regulating Neutral Endopeptidase
A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.
Fibrous Dysplasia of Bone
A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).
Calcitriol
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Acidosis, Renal Tubular
A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
Femoral Neck Fractures
Fractures of the short, constricted portion of the thigh bone between the femur head and the trochanters. It excludes intertrochanteric fractures which are HIP FRACTURES.
Phenytoin
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
Genetic Diseases, X-Linked
Genetic diseases that are linked to gene mutations on the X CHROMOSOME in humans (X CHROMOSOME, HUMAN) or the X CHROMOSOME in other species. Included here are animal models of human X-linked diseases.
Parathyroid Hormone
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Strontium
An element of the alkaline earth family of metals. It has the atomic symbol Sr, atomic number 38, and atomic weight 87.62.
Lymphangiectasis, Intestinal
Dilatation of the intestinal lymphatic system usually caused by an obstruction in the intestinal wall. It may be congenital or acquired and is characterized by DIARRHEA; HYPOPROTEINEMIA; peripheral and/or abdominal EDEMA; and PROTEIN-LOSING ENTEROPATHIES.
Hypocalcemia
Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
Fractures, Spontaneous
Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)
Cholecalciferol
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
Sunlight
Irradiation directly from the sun.
Bone Diseases, Metabolic
Calcifediol
The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Chondroma
A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed)
Hyperparathyroidism, Secondary
Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.
Osteoporosis
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
Sodium-Phosphate Cotransporter Proteins, Type IIc
A non-electrogenic sodium-dependent phosphate transporter. It is found primarily in apical membranes of PROXIMAL RENAL TUBULES.
Gastrectomy
Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)
Mandibular Fractures
Fractures of the lower jaw.
Glutethimide
A hypnotic and sedative. Its use has been largely superseded by other drugs.
Bone Matrix
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
Mandibular Neoplasms
Tumors or cancer of the MANDIBLE.
Anemia, Refractory
A severe sometimes chronic anemia, usually macrocytic in type, that does not respond to ordinary antianemic therapy.
Bisphosphonate-Associated Osteonecrosis of the Jaw
Necrotic jaws or other maxillofacial skeleton necrosis associated with bisphosphonate use (see BISPHOSPHONATES). Injury, dental procedures, and trauma can trigger the necrotic process.
Calcium Metabolism Disorders
Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.
Maxillary Diseases
Whole Body Imaging
The creation of a visual display of the inside of the entire body of a human or animal for the purposes of diagnostic evaluation. This is most commonly achieved by using MAGNETIC RESONANCE IMAGING; or POSITRON EMISSION TOMOGRAPHY.
Minerals
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Malabsorption Syndromes
General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.
Purpura, Hyperglobulinemic
Purplish or brownish red discoloration of the skin associated with increase in circulating polyclonal globulins, usually GAMMA-GLOBULINS. This syndrome often occurs on the legs of women aged 20 to 40 years.
Osteocytes
Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.
Muscular Diseases
Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.
Mandibular Diseases
Iatrogenic Disease
Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.
Bone Density
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Renal Dialysis
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Bone Neoplasms
Tumors or cancer located in bone tissue or specific BONES.
Parathyroid Glands
Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.
Bone Remodeling
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Uremia
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
Bone Density Conservation Agents
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
Celiac Disease
A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.
Anticonvulsants
Drugs used to prevent SEIZURES or reduce their severity.
Parathyroid Neoplasms
Tumors or cancer of the PARATHYROID GLANDS.
Liver Cirrhosis, Biliary
FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cirrhosis involves the destruction of small intra-hepatic bile ducts and bile secretion. Secondary biliary cirrhosis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.
Osteoblasts
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
Soft Tissue Neoplasms
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Intestinal Absorption
Uptake of substances through the lining of the INTESTINES.
Kidney
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Calcium, Dietary
Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
Phenobarbital
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Tibia
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
Ferric Compounds
Inorganic or organic compounds containing trivalent iron.
Epilepsy
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Femur
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Osteomalacia
Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.
Saudi Arabia
Extracellular Matrix Proteins
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
Biopsy
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Kidney Diseases
Pathological processes of the KIDNEY or its component tissues.
Creatinine
Diet
Regular course of eating and drinking adopted by a person or animal.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Risk Factors
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

Biochemical indices of osteomalacia in pregnant Asian immigrants in Britain. (1/293)

Serum calcium, phosphate and alkaline phosphatase, and urinary calcium excretion were examined during the second trimester of uncomplicated normal pregnancy in Asian immigrants to Britain and in local Caucasians. The mean serum calcium was significantly lower in Asians than in Caucasians, and the mean serum alkaline phosphatase was significantly higher in Asians. The geometric mean of the urinary calcium excretion was highly significantly lower in Asians than in Caucasians. The variances of the serum calcium, serum alkaline phosphatase, and urine calcium excretion did not differ significantly in the two populations. This indicates that there is a shift in values of immigrant Asians as a group compared with Caucasians. A comparison with figures obtained on normal nonpregnant persons of both suggests that the shift is not an inherent feature of the Asian population.  (+info)

Use of ultrasonography in the diagnosis of osteomalacia: preliminary results on experimental osteomalacia in the rat. (2/293)

This study was performed to investigate the ability of ultrasonographic technique to distinguish osteomalacia from normal bone with the same mineral content. Ten rats with experimentally induced osteomalacia (group A) and 12 control rats having similar body size and weight (group B) were studied. Histomorphometric analysis confirmed the presence of osteomalacia in two rats from group A and showed normally mineralized bone in two rats from group B. Whole body bone mineral density, measured by dual-energy x-ray absorptiometry, was similar in the two groups (86 +/- 6 mg/cm2 in group A and 89 +/- 4 mg/cm2 in group B). The velocity of the ultrasound beam in bone was measured by densitometer at the first caudal vertebra of each rat. The velocity was measured when the first peak of the waveform reached a predetermined minimum amplitude value (amplitude-dependent speed of sound) as well as at the lowest point of this curve before it reaches the predetermined minimum amplitude (first minimum speed of sound). Although the amplitude-dependent speed of sound was similar in the two groups (1381.9 +/- 11.8 m/s in group A and 1390.9 +/- 17.8 m/s in group B), the first minimum speed of sound was clearly different (1446.1 +/- 8.9 m/s in group A and 1503.3 +/- 10.9 m/s in group B; P < 0.001). This study shows that ultrasonography could be used to identify alterations in bone quality, such as osteomalacia, but further studies need to be carried out before this method can be introduced into clinical practice.  (+info)

Bone histology in patients with nephrotic syndrome and normal renal function. (3/293)

BACKGROUND: The prevalence of metabolic bone disease in patients with nephrotic syndrome (NS) at normal level of renal function remains uncertain. METHODS: To address this issue, we studied 30 patients (20 men and 10 women, mean age 27.3 +/- 11.7 years) with NS who had normal renal function (mean creatinine clearance 103 +/- 4 ml/min). We evaluated their serum calcium, phosphorus, alkaline phosphatase, immunoreactive parathyroid hormone (iPTH), vitamin D metabolites, urinary calcium, and skeletal survey. The extent of bone mineralization was analyzed by histomorphometric analysis of iliac crest bone biopsy specimens in all patients. The findings on bone histology were correlated with biochemical parameters. RESULTS: The mean duration of NS was 35.5 +/- 26.9 months, with a protein excretion of 7.3 +/- 3.2 g/24 hr and a serum albumin of 2.2 +/- 0.8 g/dl. Total serum calcium was 7.8 +/- 0.8 mg/dl, whereas ionized calcium was 5.7 +/- 0.7 mg/dl, phosphorus 3.2 +/- 1.2 mg/dl, and alkaline phosphatase 149 +/- 48.6 U/liter. Serum iPTH levels were normal in all except two patients. The mean serum 25-hydroxyvitamin D [25(OH)D] level was 3.9 +/- 1.2 ng/ml (normal 15 to 30 ng/ml), whereas 1,25-dihydroxyvitamin D was 24 +/- 4.7 pg/ml (normal 16 to 65). There was an inverse correlation between serum levels of 25(OH)D and the magnitude of proteinuria (r = -0.42, P < 0.05). The mean 24-hour urinary calcium excretion was 82 +/- 21 mg/day. The skeletal survey was normal in all patients. Bone histology was normal in 33.3% of the patients, whereas 56.7% had isolated osteomalacia (OSM), and 10% had an increased bone resorption in association with defective mineralization. The severity of OSM measured by mineralization lag time correlated linearly with the duration (r = 0.94, P < 0.0001) and the amount (r = 0.97, P < 0.0001) of proteinuria. All patients with NS for more than three years had histological changes. Patients with OSM had lower 25(OH)D and serum albumin as compared with those with normal histology (P < 0.005). Bone mineralization had no significant correlation with serum iPTH, divalent ions, or vitamin D levels. CONCLUSIONS: OSM is a frequent finding in adult patients with NS, even at a normal level of renal function. Its severity correlates with the amount and duration of proteinuria.  (+info)

Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. (4/293)

For adults, the 5-microg (200 IU) vitamin D recommended dietary allowance may prevent osteomalacia in the absence of sunlight, but more is needed to help prevent osteoporosis and secondary hyperparathyroidism. Other benefits of vitamin D supplementation are implicated epidemiologically: prevention of some cancers, osteoarthritis progression, multiple sclerosis, and hypertension. Total-body sun exposure easily provides the equivalent of 250 microg (10000 IU) vitamin D/d, suggesting that this is a physiologic limit. Sailors in US submarines are deprived of environmentally acquired vitamin D equivalent to 20-50 microg (800-2000 IU)/d. The assembled data from many vitamin D supplementation studies reveal a curve for vitamin D dose versus serum 25-hydroxyvitamin D [25(OH)D] response that is surprisingly flat up to 250 microg (10000 IU) vitamin D/d. To ensure that serum 25(OH)D concentrations exceed 100 nmol/L, a total vitamin D supply of 100 microg (4000 IU)/d is required. Except in those with conditions causing hypersensitivity, there is no evidence of adverse effects with serum 25(OH)D concentrations <140 nmol/L, which require a total vitamin D supply of 250 microg (10000 IU)/d to attain. Published cases of vitamin D toxicity with hypercalcemia, for which the 25(OH)D concentration and vitamin D dose are known, all involve intake of > or = 1000 microg (40000 IU)/d. Because vitamin D is potentially toxic, intake of >25 microg (1000 IU)/d has been avoided even though the weight of evidence shows that the currently accepted, no observed adverse effect limit of 50 microg (2000 IU)/d is too low by at least 5-fold.  (+info)

Is low plasma 25-(OH)vitamin D a major risk factor for hyperparathyroidism and Looser's zones independent of calcitriol? (5/293)

BACKGROUND: Recent reports suggest that calcitriol might not be the sole active metabolite of vitamin D and that plasma concentrations of 25-(OH)vitamin D (25OHD) are often abnormally low in hemodialysis patients. We have therefore evaluated plasma 25OHD as a risk factor for parathyroid hormone (PTH) hypersecretion and radiological bone disease. We carried out a cross-sectional study during the month of September in an Algerian dialysis center of 113 patients who were not taking supplements of alphacalcidol or calcitriol. METHODS: Plasma 25OHD, calcitriol, PTH, calcium, phosphate, bicarbonate, and aluminum were measured, and x-rays of the hands and pelvis were obtained for evaluation of subperiosteal resorption and Looser's zones. RESULTS: The median plasma 25OHD was 47.5 nmol/liter (range 2.5 to 170.0). Univariate analysis showed that plasma PTH was correlated positively with months on maintenance dialysis and negatively with plasma 25OHD, calcitriol, calcium, bicarbonate and aluminum, but not with that of phosphate. plasma 25OHD was positively correlated with calcium and calcitriol. Using multiple regression analysis, only plasma 25OHD (negative) and the duration on maintenance dialysis (positive) were independently linked to plasma PTH. The prevalence of isolated subperiosteal resorption (ISR) was 34%, and that of the combination of resorption with Looser's zones (CRLZ) was 9%; thus, only 57% of the patients had a normal x-ray appearance. These groups were comparable with regards to age, gender, and duration on dialysis. When the biochemical measurements of the patients with CRLZ were compared with those from patients without radiological lesions, plasma 25OHD was the only parameter to show a statistically significant difference, being significantly lower in the CRLZ group (26 +/- 18 vs. 57 nmol/liter, ANOVA, P < 0.004). Plasma 25OHD was also significantly lower in the ISR group (44, P < 0.05) than in the normal x-ray group, and plasma Ca (P < 0.003) and bicarbonate (P < 0.02) were lower. Logistical analysis showed that the presence of resorption was independently linked only with plasma PTH. Looser's zones and subperiosteal resorption were not seen in patients with plasma 25OHD of more than 40 (Looser's zones) and more than 100 nmol/liter (subperiosteal resorption). The optimal range for intact PTH in hemodialysis patients with mild aluminum overload is 10 to 25 pmol/liter. We found that plasma PTH was inappropriately high only when plasma 25OHD was less than 100 nmol/liter. With a plasma 25OHD of between 100 and 170 nmol/liter, hypercalcemia was present with a plasma PTH of less than 10 pmol/liter in only one case. CONCLUSIONS: This cross sectional study shows that low plasma 25OHD is a major risk factor for hyperparathyroidism and Looser's zones. In dialysis patients, we suggest that the plasma levels of 25OHD are maintained around the upper limit of the reference range of sunny countries.  (+info)

Bone scintigraphy in renal osteodystrophy. (6/293)

Bone scintigraphy with Tc-99m HEDP was performed in 30 patients on maintenance hemodialysis, and the results of quantitative analysis were compared with those of a normal group. To permit this comparison, elevated background activity due to the absence of renal radiotracer excretion was reduced by hemodialysis to levels found in the normals. Histologic proof of renal osteodystrophy had been obtained in all patients. The incidence of radiographic abnormalities was 46%, whereas abnormal scans were found in 25 patients (83%); skeletal lesions were also more pronounced and detected earlier. However, even when the scans appeared normal, the quantitative analysis showed increased skeletal activity in all patients. The total skeletal activity proved to be a good index of the severity of renal osteodystrophy and appeared dependent on both osteomalacia and hyperparathyroidism. These findings show that bone scintigraphy is a sensitive method to detect skeletal involvement in renal osteodystrophy.  (+info)

Increased bone strontium levels in hemodialysis patients with osteomalacia. (7/293)

BACKGROUND: In this study, we report on the association between increased bone strontium levels and the presence of osteomalacia in end-stage renal failure patients treated by hemodialysis. METHODS: We performed a histologic examination and determined the strontium content and strontium/calcium ratios in bone biopsies of 100 hemodialysis patients recruited from various centers all over the world. Aside from the bone strontium concentration, the bone aluminum content was assessed. The bone zinc concentration, a nonrelevant element for bone toxicity, was also measured. RESULTS: Bone strontium levels and bone strontium/calcium ratios were increased in subjects with osteomalacia when compared with those with the other types of renal osteodystrophy. Bone strontium and bone calcium levels correlated with each other. The slope of the linear regression curve correlating these parameters was much steeper in the osteomalacic group (Y = 2.22X - 120) as compared with the other types of renal osteodystrophy (Y = 0.52X - 5.7). Within the group of patients with osteomalacia, bone strontium levels also significantly correlated with the bone aluminum content (r = 0.72, P = 0.018). No such correlation was found for the other types of renal osteodystrophy. The bone zinc concentration of subjects with normal renal function did not differ significantly from the values noted for the various types of renal osteodystrophy taken as separate groups, nor could increased bone zinc concentrations be associated with a particular bone lesion. CONCLUSIONS: Our data demonstrate an association between osteomalacia and increased bone strontium concentrations in dialysis patients. Further studies are warranted to establish whether strontium plays either a primary, secondary, or contributive role in the development of the latter type of renal osteodystrophy.  (+info)

Use of quantitative ultrasonography in differentiating osteomalacia from osteoporosis: preliminary study. (8/293)

The aim of this work was to use ultrasonographic technology to differentiate osteoporosis from osteomalacia on the basis of different patterns of the graphic trace. Three patients with osteomalacia and three with osteoporosis, all with the same lumbar spine bone mineral density, were studied. The velocity of the ultrasound beam in bone was measured by a DBM Sonic 1,200/I densitometer at the proximal phalanges of the hands in all the patients. The ultrasound beam velocity was measured when the first peak of the waveform reached a predetermined minimum amplitude value (amplitude-dependent speed of sound) as well as at the lowest point prior to the first and second peaks, before they reached the predetermined minimum amplitude value (first and second minimum speeds of sound). The graphic traces were further analyzed by Fourier analysis, and both the main frequency (f0) and the width of the peak centered in the f0 (full width at half maximum) were measured. The first and second minimum speeds of sound were significantly lower in the patients with osteomalacia than in the osteoporosis group. The first minimum speed of sound was 2,169 +/- 73 m/s in osteoporosis and 1,983 +/- 61 m/s in osteomalacia (P < 0.0001); the second minimum peak speed of sound was 1,895 +/-59 m/s in osteoporosis and 1,748 +/- 38 m/s in osteomalacia (P < 0.0001). The f0 was similar in the two groups (osteoporosis, 0.85 +/- 0.14 MHz; osteomalacia, 0.9 +/- 0.22 MHz; P = 0.72), and the full width at half maximum was significantly higher in the osteomalacia patients (0.52 +/- 0.14 MHz) than in the osteoporosis patients (0.37 +/- 0.15 MHz) (P = 0.022). This study confirms that ultrasonography is a promising, noninvasive method that could be used to differentiate osteoporosis from osteomalacia, but further studies should be carried out before this method can be introduced into clinical practice.  (+info)

Myopathy in hypophosphataemic osteomalacia presenting in adult life. | Journal of Neurology, Neurosurgery & PsychiatryMyopathy in hypophosphataemic osteomalacia presenting in adult life. | Journal of Neurology, Neurosurgery & Psychiatry
Our requirements are stated in our rapid response terms and conditions and must be read. These include ensuring that: i) you do not include any illustrative content including tables and graphs, ii) you do not include any information that includes specifics about any patients,iii) you do not include any original data, unless it has already been published in a peer reviewed journal and you have included a reference, iv) your response is lawful, not defamatory, original and accurate, v) you declare any competing interests, vi) you understand that your name and other personal details set out in our rapid response terms and conditions will be published with any responses we publish and vii) you understand that once a response is published, we may continue to publish your response and/or edit or remove it in the future ...
https://jnnp.bmj.com/content/38/3/297.responses
A rare case of Oncogenic Osteomalacia treated at Apollo Hospitals, Chennai
A rare case of Oncogenic Osteomalacia treated at Apollo Hospitals Chennai. Oncogenic Osteomalacia is a rare condition causing debilitating illness.
https://www.apollohospitals.com/departments/orthopedic/case-studies/a-rare-case-of-oncogenic-osteomalacia-treated-at-apollo-hospitals-chennai
Biochemical abnormalities in Pearson syndrome | Hereditary Ocular DiseasesBiochemical abnormalities in Pearson syndrome | Hereditary Ocular Diseases
Crippa BL, Leon E, Calhoun A, Lowichik A, Pasquali M, Longo N. Biochemical abnormalities in Pearson syndrome. Am J Med Genet A. 2015 Mar;167(3):621-8.. ...
https://disorders.eyes.arizona.edu/references/biochemical-abnormalities-pearson-syndrome
Study of Longitudinal Observation for Patient With X-linked Hypophosphatemic Rickets/Osteomalacia in Collaboration With Asian...Study of Longitudinal Observation for Patient With X-linked Hypophosphatemic Rickets/Osteomalacia in Collaboration With Asian...
Clinical trial for Familial Hypophosphatemic Rickets , Study of Longitudinal Observation for Patient With X-linked Hypophosphatemic Rickets/Osteomalacia in Collaboration With Asian Partners
https://www.centerwatch.com/clinical-trials/listings/216836/study-of-longitudinal-observation-for-patient-with-x-linked-hypophosphatemic-ricketsosteomalacia-in-collaboration-with-asian-partners/
Treatment and outcomes of tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors: retrospective review of...Treatment and outcomes of tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors: retrospective review of...
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by severe hypophosphatemia and osteomalacia. Nonspecific symptoms make the diagnosis elusive. In addition, locating the responsible tumor(s) is challenging. The aim of this study was to investigate the clinical management and outcomes of TIO. The clinical features, diagnostic procedures, treatment, and outcomes of 12 patients were reviewed retrospectively. The cohort comprised six men and six women (mean age 45.5 ± 9.9 years, range 23-61 years). The mean duration of disease was 3.7 ± 2.6 years. All patients manifested progressive bone pain, muscle weakness, and/or difficulty walking. Serum phosphorus concentrations were low in all patients (mean 0.42 ± 0.12 mmol/L). Technetium-99m octreotide scintigraphy was performed in 11 patients and showed lesions in the right distal femur, left femoral head, and right tibial plateau, respectively, in three patients. Magnetic resonance imaging (MRI) was negative for lesions in one
https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-017-1756-1
Hypophosphataemic Osteomalacia and Myopathy: Studies with Nuclear Magnetic Resonance Spectroscopy | Clinical ScienceHypophosphataemic Osteomalacia and Myopathy: Studies with Nuclear Magnetic Resonance Spectroscopy | Clinical Science
1. A patient with familial adult-onset hypophosphataemia, whose myopathy was closely related to the plasma phosphate concentration, was investigated by phosphorus nuclear magnetic resonance spectroscopy (31P n.m.r.) in vivo of the right flexor digitorum superficialis muscle.. 2. During hypophosphataemia induced by stopping oral phosphate a significant reduction in measured muscle strength occurred, but the ratios of the intramyocellular levels of phosphocreatine (PCr), adenosine triphosphate (ATP) and inorganic phosphate (Pi) remained unchanged at rest. During exercise these levels changed, as did the intramyocellular pH, but they did not differ from the pattern previously recorded in normal subjects.. 3. In four adults with inherited infantile-onset hypophosphataemia (vitamin D-resistant rickets, VDRR) without myopathy, the n.m.r. measurements were normal at rest and during exercise.. 4. In one patient with inherited hyperphosphataemia (tumoral calcinosis) the resting PCr: Pi ratio was ...
http://www.clinsci.org/content/67/5/505
Oncogenic osteomalacia. | Journal of Clinical PathologyOncogenic osteomalacia. | Journal of Clinical Pathology
Severe osteomalacia (confirmed by the examination of thin undecalcified bone biopsy sections) associated with hypophosphataemia developed in a 60 year old woman. A skeletal x-ray survey showed a lytic lesion in the right proximal femur, and this was curetted, showing a vascular tumour. The patients symptoms improved almost immediately and serum phosphate concentrations returned to normal. Some time later the syndrome and the tumour recurred. The tumour was excised, and again the patient improved. Morphological examination of the tumour showed a lesion which closely resembled haemangiopericytoma. Review of published reports confirmed that most reported cases have been associated with vascular mesenchymal tumours both in intraosseous and extraosseous sites.. ...
http://jcp.bmj.com/content/40/4/446
FDA Approves CRYSVITA for Tumor-Induced Osteomalacia - Patient WorthyFDA Approves CRYSVITA for Tumor-Induced Osteomalacia - Patient Worthy
The FDA has recently approved CRYSVITA for the treatment of tumor-induced osteomalacia (TIO). Read all about it here at PatientWorthy!
https://patientworthy.com/2020/06/29/crysvita-approved-for-tumor-induced-osteomalacia/
Oncogenic Osteomalacia and Inappropriate Antidiuretic Hormone Secretion Due to Oat-Cell Carcinoma | Annals of Internal Medicine...Oncogenic Osteomalacia and Inappropriate Antidiuretic Hormone Secretion Due to Oat-Cell Carcinoma | Annals of Internal Medicine...
The syndrome of tumor-induced osteomalacia has been previously thought to occur only in association with mesenchymal tumors, although one report has linked prostatic carcinoma with the syndrome. We report the case of a patient who presented first with the clinical and biochemical features of the syndrome of inappropriate antidiuretic hormone secretion, and then oncogenic osteomalacia. The first syndrome was characterized by headaches, nausea, and vomiting; serum sodium determinations ranged between 107 and 118 meq/L with simultaneous urine spot sodium concentrations of 100 to 116 meq/L. The circulating antidiuretic hormone level was markedly elevated to 261.5 µU/mL. The osteomalacia was discovered incidentally when depressed serum phosphorus levels of 1.2 to 1.7 mg/dL were noted in association with 24-hour urine phosphorus excretion exceeding 1000 mg/24 h. Undecalcified tetracycline-labeled bone biopsy samples confirmed oncogenic osteomalacia. Only afterward was a small-cell carcinoma of the ...
http://annals.org/aim/article-abstract/699230/oncogenic-osteomalacia-inappropriate-antidiuretic-hormone-secretion-due-oat-cell-carcinoma
Association of hypophosphatemic osteomalacia with neurofibromatosis type 1 - - ScopeMed.org - Deposit for Medical ArticlesAssociation of hypophosphatemic osteomalacia with neurofibromatosis type 1 - - ScopeMed.org - Deposit for Medical Articles
Oncogenic hypophostphatemic osteomalacia is rare form of osteomalacia with few cases reported in the literature. It is characterized by later onset in adulthood, renal phosphate loss with hypophosphatemia and poor bone mineralization. The syndrome is associated with mesenchymal tumours or prostatic CA. We report a case of oncogenic hypophosphatemic ostoemalacia associated with neurofibromatosis.. Key words: Oncogenic hypophoosphatemic osteomalacia, neurofibromatosis, mesenchymal tumors ...
http://www.scopemed.org/?mno=223401
Malignant transformation of phosphaturic mesenchymal tumor: A case report and literature review - Fingerprint - Kyushu...
Dive into the research topics of Malignant transformation of phosphaturic mesenchymal tumor: A case report and literature review. Together they form a unique fingerprint. ...
https://kyushu-u.pure.elsevier.com/en/publications/malignant-transformation-of-phosphaturic-mesenchymal-tumor-a-case/fingerprints/?sortBy=alphabetically
Final Diagnosis -- Case 196Final Diagnosis -- Case 196
DIAGNOSIS Phosphaturic Mesenchymal Tumor, Mixed Connective Tissue Variant (PMT-MCT). DISCUSSION. Osteomalacia is a bone disease characterized by gradual softening and bending of the bones due to inadequate mineralization of osteoid. The most common etiologies of osteomalacia include vitamin D deficiency and renal tubular dysfunction; however, in rare instances, osteomalacia can be associated with bone and soft tissue tumors as a paraneoplastic syndrome (i.e. oncogenic osteomalacia) (1, 4, 8). Though the mechanism behind the inadequate mineralization of osteoid in this setting is not entirely understood, it is hypothesized that tumor over-expression of FGF-23 may play a role. This protein appears to inhibit trans-epithelial phosphate transport in renal tubules, resulting in renal phosphate wasting and subsequent osteomalacia (2-4, 11). While a heterogeneous group of tumors may cause oncogenic osteomalacia, PMT-MCT is the most common (1, 6). Tumors associated with oncogenic osteomalacia are ...
http://path.upmc.edu/divisions/neuropath/bpath/cases/case196/dx.html
Tumor-induced osteomalacia: The tumor may stay hidden! - van der Rest CatherineTumor-induced osteomalacia: The tumor may stay hidden! - van der Rest Catherine
en] We report the case of a patient with severe muscular and articular tenderness that caused almost complete immobility. This subject had severe hypophosphatemia due to hyperphosphaturia. Fibroblast growth factor 23 (FGF-23) was abnormally high and the diagnostic of tumor-induced osteomalacia was made. Despite multiple tests, the tumor was not localized. In this report, we discuss different possible investigations to localize the tumor. Lastly, we review the potential therapy available when tumor is not found and can thus not ...
http://orbi.ulg.ac.be/handle/2268/98453
FGF23 - Renal Fellow NetworkFGF23 - Renal Fellow Network
For many years, the existence of phosphatonins-substances secreted by certain tumors which result in profound renal phosphorus wasting and resultant osteomalacia-has been postulated.. Evidence has recently been accumulating that fibroblast growth factor 23 (FGF-23) is the phosphatonin we have been searching for:. High circulating levels of FGF23 are associated with hypophosphatemia, decreased 1,25 (OH) vitamin D levels, and rickets/bone disease.. The disease autosomal dominant hypophosphatemic rickets is caused by gain-of-function mutations in FGF23caused by splice site mutations. Conversely, the genetic disease inherited tumoral calcinosis, characterized by hyperphosphatemia, increased 1,25 (OH) vitamin D levels, and metastatic calcifications.. In ESRD, FGF23 levels are appropriately elevated in response to hyperphosphatemia, but due to a reduced GFR is unable to induce adequate phosphaturia.. How it works at a molecular level: FGF23 interacts with FGF receptors at the proximal tubule, ...
https://www.renalfellow.org/2008/04/27/fgf23/
LORDS L 159 RECALCIFYING DROPSLORDS L 159 RECALCIFYING DROPS
Composition: Sillicea 30x, Hekla Lava 12x, Calc. Phos 12x, Calc. Hypophos 6x, Chamomilla. 6x, Calc, Fluor 12x, Mercur Prace. Ruber 12x, Mezereum. 6x. Indications: Helpful in the growth of bones where fragility develops in conditions like rickets osteomalacia, arthritis and in nucleus pulposus. ...
https://www.homeopathy4all.com/0155-LORDS-L-159-RECALCIFYING-DROPS-Drops-LORDS
Metabolic Bone Disease MBD causes in HedgehogsMetabolic Bone Disease MBD causes in Hedgehogs
In recent years there has been an increase in the diagnosis of Metabolic Bone disease in hedgehogs and it is a life-threatening syndrome. While the
https://www.arkwildlife.co.uk/Wildlife/Post/300/Metabolic_Bone_Disease_MBD_causes_in_Hedgehogs.html
Metabolic bone disease - Latest research and news | NatureMetabolic bone disease - Latest research and news | Nature
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.. ...
https://www.nature.com/subjects/metabolic-bone-disease?error=cookies_not_supported&code=e1fe1a1b-1bb0-4ce8-9c55-43c708eb7b8d
A 61-year-old woman with osteomalacia and a thoracic spine lesion<...
TY - JOUR. T1 - A 61-year-old woman with osteomalacia and a thoracic spine lesion. AU - Marshall, Ann E.. AU - Martin, Sarah E.. AU - Agaram, Narasimhan P.. AU - Chen, Jey Hsin. AU - Horn, Eric. AU - Douglas-Akinwande, Annette C.. AU - Hattab, Eyas M.. PY - 2010/3. Y1 - 2010/3. N2 - Phosphaturic mesenchymal tumor, mixed connective tissue variant (PMT-MCT) is a rare, largely benign, mesenchymal neoplasm almost invariably associated with oncogenic osteomalacia. It is generally found in the soft tissue and bone of the extremities. We report a case of a 61-year-old female with long-standing osteomalacia who was found to have PMT-MCT of the thoracic spine. There have been very few previously reported cases of PMT involving the spinal vertebrae and neuropathologists should be aware of this lesion. Recognition of PMT-MCT is critical for optimal patient care since complete surgical resection without additional therapy is curative.. AB - Phosphaturic mesenchymal tumor, mixed connective tissue variant ...
https://indiana.pure.elsevier.com/en/publications/a-61-year-old-woman-with-osteomalacia-and-a-thoracic-spine-lesion
RTRP2 - Overview: Tubular Reabsorption of Phosphorus, Random Urine and SerumRTRP2 - Overview: Tubular Reabsorption of Phosphorus, Random Urine and Serum
RTRP2 : Assessing renal reabsorption of phosphorus in a variety of pathological conditions associated with hypophosphatemia including hypophosphatemic rickets, tumor-induced osteomalacia, and tumoral calcinosis   Adjusting phosphate replacement therapy in severe deficiency states monitoring the renal tubular recovery from acquired Fanconi syndrome
https://www.mayocliniclabs.com/test-catalog/Overview/614047
Alkaline phosphatase levels in children - Doctor answersAlkaline phosphatase levels in children - Doctor answers
Alkaline phosphatase levels in children - Medicine for high alkaline phosphatase levels? Wrong approach. Alkaline phosphatase is a lab value to tell a physician what is happening, not a medical problem to treat. It can be high just because you
https://www.healthtap.com/topics/alkaline-phosphatase-levels-in-children
Bone disease - Metabolic bone disease | Britannica.comBone disease - Metabolic bone disease | Britannica.com
Bone disease - Metabolic bone disease: The normal function of bone requires an adequate supply of amino acids (the building blocks for proteins) for the synthesis of collagen, the chief component of the organic matrix; of calcium and phosphate for mineralization of the organic matrix; and of other organic compounds and mineral elements. Also, growth, repair, and remodeling of the bone tissue require a precisely regulated supply of hormones, vitamins, and enzymes. Skeletal disease, when it is due to inadequacies in the supply or action of the above essentials, associated with abnormalities outside the skeleton, is termed metabolic; in such cases the entire skeleton is affected.
https://www.britannica.com/science/bone-disease/Metabolic-bone-disease
Metabolic Bone Diseases Clinic | Tufts Medical CenterMetabolic Bone Diseases Clinic | Tufts Medical Center
The Metabolic Bone Diseases Clinic at Tufts Medical Center in Boston provides care to manage increased risk for fragility fractures due to bone diseases, like osteoporosis.
https://www.tuftsmedicalcenter.org/patient-care-services/Departments-and-Services/Endocrinology/Clinical-Care-Services/Bone-and-Calcium-Metabolism-Clinic.aspx
Chapter 9. Animal Models: Allelic Determinants for BMD - Primer on the Metabolic Bone Diseases and Disorders of Mineral...Chapter 9. Animal Models: Allelic Determinants for BMD - Primer on the Metabolic Bone Diseases and Disorders of Mineral...
ASBMR (2008) Chapter 9. Animal Models: Allelic Determinants for BMD, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470623992.ch9 ...
http://onlinelibrary.wiley.com/doi/10.1002/9780470623992.ch9/summary?globalMessage=0&systemMessage=Wiley+Online+Library+usage+report+download+page+will+be+unavailable+on+Friday+24th+November+2017+at+21%3A00+EST+%2F+02.00+GMT+%2F+10%3A00+SGT+%28Saturday+25th+Nov+for+SGT+
NIH Clinical Center: NIH and Middle East Cure Rare TumorNIH Clinical Center: NIH and Middle East Cure Rare Tumor
In November 2015, Jumana, a teenage patient, arrived at the NIH seeking a cure for a rare disease that made her bones so fragile and muscles so weak that she was confined to her bed, barely able to lift her legs. Earlier this year, after a medical collaboration by NIH researchers and others around the world, Jumana was cured and is able to walk again.. The patient, who traveled nearly 6,000 miles from her home in the Palestinian territories to the Clinical Center, had a disease called tumor-induced osteomalacia (TIO). TIO is caused by a rare endocrine tumor that secretes FGF23, a hormone that regulates phosphate absorption and active vitamin D production. In high levels, as is seen in TIO, it causes low blood phosphate levels that leads to muscle weakness, bone pain and fractures.. There are only a few places in the world with expertise in diagnosing and treating TIO. When clinicians in Israel diagnosed the condition in this patient, but couldnt find the tumor, they called Dr. Michael Collins, ...
https://www.cc.nih.gov/about/news/newsletter/2016/winter/story-winter-nih-and-middle-east-cure-rare-tumor.html
Osteitis Fibrosa CysticaOsteitis Fibrosa Cystica
A 48-year-old man who had recently immigrated to France and had not yet established routine medical care presented to the emergency department with shortness
https://medizzy.com/feed/19441194
PET/CT localisation of a scapular haemangiopericytoma with tumour-induced osteomalacia | SMJPET/CT localisation of a scapular haemangiopericytoma with tumour-induced osteomalacia | SMJ
Oncogenic osteomalacia, or tumour-induced osteomalacia (TIO), is a rare paraneoplastic syndrome characterised by hypophosphataemia, phosphaturia, inappropriately low serum levels of 1,25-dihydroxyvitamin D for hypophosphataemia. TIO is caused by mesenchymal tumours that secrete phosphaturic substances, leading to increased renal wasting of phosphates. These tumours are very small in size and grow slowly. Localisation of these tumours has always been difficult with the available biochemical and imaging techniques. At times, despite all efforts, the tumour could not be localised. We report our experience with a 42-year-old woman with TIO where whole-body magnetic resonance imaging could not localise the tumour, a scapular haemangiopericytoma. PET/CT was helpful in the localisation of the tumour which, when surgically removed, resulted in the normalisation of biochemical parameters with clinical improvement.. Keywords: mesenchymal tumours, oncogenic osteomalacia, paraneoplastic syndrome, scapular ...
http://www.smj.org.sg/article/petct-localisation-scapular-haemangiopericytoma-tumour-induced-osteomalacia
Phosphaturic Mesenchymal Tumor of the Cerebellopontine Angle | Neuro-oncology | JAMA Otolaryngology-Head & Neck Surgery | JAMA...Phosphaturic Mesenchymal Tumor of the Cerebellopontine Angle | Neuro-oncology | JAMA Otolaryngology-Head & Neck Surgery | JAMA...
This case report describes an otherwise healthy woman in her 30s who presented with left-ear hearing loss, tinnitus, distorted hearing, and occasional otalgia o
https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2723086
Johns Hopkins Medicine: Find a DoctorJohns Hopkins Medicine: Find a Doctor
Expertise, Disease and Conditions: Bone Disorders, Calcium disorders, Endocrinology, Glucocorticoid Induced Osteoporosis, Hypercalcemia, Hyperparathyroidism, Male Osteoporosis, Metabolic Bone Disease, Osteomalacia, Osteoporosis, Pagets Disease, Pseudohypoparathyroidism, Rickets, Right Heart Catheterization, Tumor-Induced Osteomalacia, X Linked Hypophosphatemic Rickets (XLH ...
http://www.hopkinsmedicine.org/profiles/results/directory/?pagecount=20&currpage=1&spec_disease=Endocrinology&setsize=10&dbase=main&CLEARPAGECACHE=false
Johns Hopkins Medicine: Find a DoctorJohns Hopkins Medicine: Find a Doctor
Expertise, Disease and Conditions: Bone Disorders, Calcium disorders, Endocrinology, Glucocorticoid Induced Osteoporosis, Hypercalcemia, Hyperparathyroidism, Male Osteoporosis, Metabolic Bone Disease, Osteomalacia, Osteoporosis, Pagets Disease, Pseudohypoparathyroidism, Rickets, Right Heart Catheterization, Tumor-Induced Osteomalacia, X Linked Hypophosphatemic Rickets (XLH ...
https://www.hopkinsmedicine.org/profiles/results/directory/?pagecount=20&currpage=1&CLEARPAGECACHE=false&spec_disease=Endocrinology&setsize=10&dbase=main
Human 25 Hydroxy Vitamin D ELISA kit - E01H0005-96 B-Gene - Antibod...Human 25 Hydroxy Vitamin D ELISA kit - E01H0005-96 B-Gene - Antibod...
Product Human 25 Hydroxy Vitamin D ELISA kit From B-Gene - A sandwich ELISA for quantitative measurement of Human 25 Hydroxy Vitamin D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUTION*1 vial 12. WASH SOLUTION (100 x)*1 vial 13. BALANCE SOLUTION*1 vial 14. INSTRUCTION*1
https://antibody-antibodies.com/products/e01h0005-96/human-25-hydroxy-vitamin-d-elisa-kit-1094108/
Browse In FGF23 | EDM Case ReportsBrowse In FGF23 | EDM Case Reports
Phosphaturic mesenchymal tumor (PMT) represents a rare cause of osteomalacia. The clinical signs and symptoms are vague and these lead to diagnosis delay. In the presence of hypophosphatemia and relatively high urine phosphate excretion, this entity should be taken into consideration in the deferential diagnosis of osteomalacia. In the present article, we report 81-year-old man presented to our clinic for evaluation due to osteopenia. His laboratory results disclosed hypophosphatemia, relatively increased urine phosphate excretion and increased level of intact fibroblast growth factor 23 (FGF23). A 68Gallium DOTATATE PET/CT revealed pathological uptake in the upper aspect of the left shoulder adjacent to the coracoid process. For suspected PMT a wide resection of the tumor was performed and pathological findings were consistent for PMT. Laboratory tests were normalized postoperatively. Reviewing the literature, we had identified 33 reported cases of PMTs among elderly patients age ≥70 years. ...
https://edm.bioscientifica.com/browse?access_0=all&pageSize=10&sort=datedescending&t=hormone_34
25-Hydroxy Vitamin D2 and D3: 2015-2019 Test Volume and Sales Forecasts by Country and Market Segment--France, Germany, Italy,...25-Hydroxy Vitamin D2 and D3: 2015-2019 Test Volume and Sales Forecasts by Country and Market Segment--France, Germany, Italy,...
This new report from VPGMarketResearch.com provides analysis of 25-Hydroxy Vitamin D2 and D3 testing, including clinical significance, current and emerging diagnostic ...
https://www.reportlinker.com/p03215216/25-Hydroxy-Vitamin-D2-and-D3-Test-Volume-and-Sales-Forecasts-by-Country-and-Market-Segment-France-Germany-Italy-Japan-Spain-UK-USA-Hospitals-Commercial-Labs-POC-Locations.html
What does renal osteodystrophy in renal failure mean? - Answered by top doctors on HealthTapWhat does renal osteodystrophy in renal failure mean? - Answered by top doctors on HealthTap
Bone disease. People with renal failure develop weaken bones from abnormal mineralization of the bone. Renal osteodystrophy is the name of this process where calcium and phosphorus do not deposit into the bone correctly and therefore the persons bones are prone to fractures ...
https://www.healthtap.com/user_questions/27249-what-does-renal-osteodystrophy-in-renal-failure-mean
Non-Invasive Measurement of Bone Strontium LevelsNon-Invasive Measurement of Bone Strontium Levels
I am a 60-year-old female with osteoporosis. I took Fosamax 70 mg once weekly for seven months until I could no longer endure the side effects. For the following month, I took no medication. Since January 21, 2008, I have been on 680 mg strontium citrate once daily. I intend to relate my progress. My first DEXA scan was done May 8, 2007. My T-score at the lumbar spine was -3.0 (-2.0 at L1, -2.7 at L2, -3.4 at L3 and -3.8 at L4). My T-score at the left hip was -2.2 (-2.8 at neck, -2.0 at troch, -1.9 at inter). My BMD results in g/cm2 were 0.712 at the spine (L1-L4), 0.53 at the left hip (neck), and 0.670 at the left hip (total). A followup scan is planned for July 6, 2009. For these results, see: http://strontiumforbones.blogspot.com/2009/07/improved-t-scores-after-treatment. ...
http://strontiumforbones.blogspot.com/2013/08/non-invasive-measurement-of-bone.html
Defective PEX gene products correlate with the protein import, biochemical abnormalities, and phenotypic heterogeneity in...Defective PEX gene products correlate with the protein import, biochemical abnormalities, and phenotypic heterogeneity in...
On biochemical analysis, DHAP-AT activity, a membrane bound peroxisomal enzyme involved in the first step of biogenesis of plasmalogen, was severely diminished in fibroblasts from patients F-01 and F-04 with ZS (6.5% and 10.6% of control fibroblasts), determined as described previously.6 On the other hand, fibroblasts from F-05 with IRD had residual DHAP-AT activity (26.1% of the control) (table 1). Concerning β oxidation activity of lignoceric acid relative to that of palmitic acid (C24:0/C16:0), IRD fibroblasts also had residual activity (19.2% of the control), as compared to findings in fibroblasts from patients F-01 and F-04 with ZS (4.4% and 5.9% of the control), determined as described previously7 (table 1).. Next, we investigated the relationship between gene mutation, protein import machinery, and the residual activities using gene transfection. The PEX2-wild,PEX2-R125X, andPEX2-E55K gene sequences subcloned into the expression vector pUcD2SRαMCS8 were transfected toPEX2 deficient CHO ...
http://jmg.bmj.com/content/36/10/779
THU0553 Low alkaline phosphatase levels: could it be hypophosphatasia? | Annals of the Rheumatic DiseasesTHU0553 Low alkaline phosphatase levels: could it be hypophosphatasia? | Annals of the Rheumatic Diseases
Results Demographic and clinical characteristics of both groups are shown in Table 1. Of the 108 patients evaluated, the genetic test results of 39 patients are available at this moment (the rest of the results are currently pending). 59% (23/39) tested positive for the genetic mutation.Despite data are still partial and although the results did not achieve statistical significance, we observed with a greater relevance a higher proportion of patients with HPP presenting with chronic bone pain (48,7% vs 25,6%,p=0,157), muscle weakness (15,4% vs 2,6%, p=0,112) and more necessity of analgesic medication (p=0,107) in patients with HPP in comparison with the control group. Furthermore, there was a non-significant trend in the HPP-group to present dental abnormalities and premature dental loss (7,6%), absent manifestations in the control group (p=0,123). In addition, orthopedic surgery was more common in the HPP group (12,8%) compared with the other group (0%), p=0,04. The prevalence of stress ...
http://ard.bmj.com/content/76/Suppl_2/416.1
renal osteodystrophy | MEDCHROMErenal osteodystrophy | MEDCHROME
This Website, does not provide medical advice,diagnosis or treatment. Content (text, video) on this website is only intended to provide general information to the reader and for academic purpose of medical students. Please consult your doctor for medical advice, diagnosis and treatment.We do not undertake any responsibility or liability of any health issues caused by following advise on this ...
http://medchrome.com/tag/renal-osteodystrophy/
openarchives.gr | Cytogenetic studies and H.L.A. pattern in Greek patients with A,B-Lipoproteinemiaopenarchives.gr | Cytogenetic studies and H.L.A. pattern in Greek patients with A,B-Lipoproteinemia
Ελληνική Γαστροεντερολογική Εταιρία. Annals of Gastroenterology.Τμήμα περιοδικού.Επιστημονικό άρθρο.Άρθρο.2007 . Creators: Konstantellou, Helen, Argyros, N., Sambani, Constantina, Kottaras, G., Hereti, Irini, Choremi, Helen, Cheracakis, P., Christodoulou, Martha.A,â-lipoproteinemia is an extremely rare genetic disorder of lipoprotein metabolism, associated with various biochemical abnormalities combined with clinical malabsorption. The aim of this study was to provide information concerning the cytogenetic and HLA patterns of three patients with A,â-lipoproteinemia, as well as to see if there is any correlation between specific HLA type and clinical course of the disease.The study included seven persons. There were 3 patients (a girl and two boys aged 32, 30 and 22 years respectively) and their 4 healthy, first-degree relatives (two parents, a brother and a sister). Cytogenetic studies wereperformed on PHA stimulated peripheral
https://www.openarchives.gr/aggregator-openarchives/edm/gastro/000025-article_view_943
Magyarosaurus bone histology (resend)
One of these days, Im going to remember to switch to plain text when sending to the DML... :-) One could imagine this technique being used to distinguish other dwarf species... http://www.pnas.org/content/early/2010/04/29/1000781107 Guy Leahy ...
http://dml.cmnh.org/2010May/msg00033.html
sepsis Archives - CriticalCareDVMsepsis Archives - CriticalCareDVM
Low blood sugar, also known as hypoglycemia, is a relatively common biochemical abnormality documented in sick dogs and cats presented to the emergency room, as well as those hospitalized in Intensive Care Units for various illnesses. This week I spend some time discussing hypoglycemia so pet parents can be aware of this potential health issue. … [Read more…] ...
http://criticalcaredvm.com/tag/sepsis/
The locomotor and nervous systems | Basicmedical Key
Chapter 15 The locomotor and nervous systems Introduction It is convenient to consider these systems in the same chapter. Although the diseases that affect them may show little or no overlap, there are obvious functional links. This chapter is mainly devoted to the clinical biochemistry of metabolic bone disease, articular disease and muscle disease. Numerous…
https://basicmedicalkey.com/the-locomotor-and-nervous-systems/
Anatomy and Diseases of Turtle and Tortoise ShellsAnatomy and Diseases of Turtle and Tortoise Shells
A turtle shell is made of two parts: the plastron and carapace. Both are covered with scutes. Retained scutes (dysecdysis), metabolic bone disease, and trauma are common diseases of the shell.
http://www.peteducation.com/article.cfm?c=17+1797&aid=2700
HIPOFOSFATEMIA EN BOVINOS PDF
En condiciones normales la fosfaturia 24 h es de unos mg. Lo que debe asegurarse siempre es el tratamiento de la causa subyacente. Causes of hypophosphatemia. En: Up to Date. Rose BD, ed. Wellesley, MA, Agus ZS. Diagnosis and treatment of hypophosphatemia. Molecular pathogenesis of hypophosphatemic rickets. J Clin Endocrinol Metab ; Kronenberg HM. NPT2a-the key to phosphate homeostasis.. N Engl J Med ; Prolonged high-dose phosphate treatment: a risk factor for tertiary hyperparathyroidism in X-linked hypophosphatemic rickets. Clin Endocrinol Oxf ; Barcelona: Masson; Dipyridamole decreases renal phosphate leak and augments serum phosphorus in patients with low renal phosphate threshold. J Am Soc Nephrol ; Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter.. Pathophysiology of X-linked hypophosphatemia, tumor-induced osteomalacia, and autosomal dominant hypophosphatemia: a perPHEXing problem. Genetic disorders of ...
https://itkintek.ru/career/hipofosfatemia-en-bovinos.php
Renal osteodystrophy - WikipediaRenal osteodystrophy - Wikipedia
Renal osteodystrophy is currently defined as an alteration of bone morphology in patients with chronic kidney disease (CKD). It is one measure of the skeletal component of the systemic disorder of chronic kidney disease-mineral and bone disorder (CKD-MBD). The term renal osteodystrophy was coined in 1943, 60 years after an association was identified between bone disease and renal failure. The traditional types of renal osteodystrophy have been defined on the basis of turnover and mineralization as follows: mild, slight increase in turnover and normal mineralization; osteitis fibrosa, increased turnover and normal mineralization; osteomalacia, decreased turnover and abnormal mineralization; adynamic, decreased turnover and acellularity; mixed, increased turnover with abnormal mineralization. A Kidney Disease: Improving Global Outcomes report has suggested that bone biopsies in patients with CKD should be characterized by determining bone turnover, mineralization, and volume (TMV system). On the ...
https://en.wikipedia.org/wiki/Renal_osteodystrophy
Strontium For Bones: 2013Strontium For Bones: 2013
In July, 2012, four researchers at Ryerson University in Toronto, Canada, published a study in Bone entitled: Monitoring bone strontium levels of an osteoporotic subject due to self-administration of strontium citrate with a novel diagnostic tool, in vivo XRF: a case study. This study is significant because it used a non-invasive method (not an invasive method, such as bone biopsy) to analyze the strontium levels of bones in an osteoporotic patient who began taking strontium citrate for the study. Therefore, it was possible to obtain her baseline bone strontium levels prior to initiation of therapy with strontium citrate. The researchers wrote: By 120 hours, the increase (in bone strontium level) was statistically significant at 0.68 ± 0.07 and 0.93 ± 0.05 (for the finger and ankle), respectively. Further increases occurred within an interval of 90-180 days, with the most recent, after 800 days, at the finger and ankle being 7 and 15 times higher than the initial baseline reading. The ...
http://strontiumforbones.blogspot.com/2013/
Burosumab in Children and Adolescents With X-linked Hypophosphatemia - Full Text View - ClinicalTrials.govBurosumab in Children and Adolescents With X-linked Hypophosphatemia - Full Text View - ClinicalTrials.gov
In this prospective longitudinal cohort study we studied the efficacy and safety of burosumab in real-clinical practice for ,13- and ,13-years old children affected with X-linked hypophosphatemia.. 57 children with XLH were switched from conventional treatment to burosumab. After 12 months we assessed the efficacy and safety of treatment with burosumab on the whole cohort and separately on the cohort of ,13-years old adolescents. ...
https://www.clinicaltrials.gov/ct2/show/NCT04419363
Chapter 42. Genetics of Osteoporosis - Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism - Center -...Chapter 42. Genetics of Osteoporosis - Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism - Center -...
ASBMR (2008) Chapter 42. Genetics of Osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470623992.ch42 ...
http://onlinelibrary.wiley.com/doi/10.1002/9780470623992.ch42/references
Metabolic Bone Disease | UW Orthopaedics and Sports Medicine, Seattle
This clinic treats patients who have metabolic bone diseases - thin bones, thick bones, soft bones, brittle bones and irregular bones. These diseases are caused by problems with mineral metabolism, nutrition, and some genetic diseases. In addition to the above list, we see patients with many kinds of diseases, including:
http://orthop.uw.edu/?q=patient-care/metabolic-bone-disease.html
Investigation of serum 25 hydroxy vitamin D level in critically ill children and its relation with demographic and clinical...Investigation of serum 25 hydroxy vitamin D level in critically ill children and its relation with demographic and clinical...
Investigation of serum 25 hydroxy vitamin D level in critically ill children and its relation with demographic and clinical risk factors, Bahare Yaghmaie, Fatemeh Sayarifard, Moham
https://www.alliedacademies.org/articles/investigation-of-serum-25-hydroxy-vitamin-d-level-in-critically-ill-children-and-its-relation-with-demographic-and-clinical-risk-f.html
rat bone marrow mast cell maturation - Immunology and Histologyrat bone marrow mast cell maturation - Immunology and Histology
Im trying to culture rat BMMCs (from Brown Norway rats) using similar culture conditions to those weve used successfully with mouse BMMCs, but with no luck. My current media is pretty standard - RPMI, b-ME, 10% FBS, P/S/glut, sodium pyruvate. rrIl-3 added fresh, tested with and without rSCF. also tested ConA stimulated spleen conditioned media, as a source of IL-3, but my cells seemed to stick to the plate and die faster than previous cultures. I only change out half the media with each feeding, as with mouse BMMCs or the viability decreases. Very few problems with viability - routinely ,90% even after 35 days in culture. My main problem is that all of my cells keep adhering to the plastic - ive looked at the adherent cells by flow and spun some out onto slides and they appear to be monocytes / macs, which i dont want. All the suspension cells dwindle away quite quickly ...
http://www.protocol-online.org/biology-forums/posts/34074.html
Electrolyte management: hypophosphatemia synonyms, electrolyte management: hypophosphatemia antonyms - FreeThesaurus.comElectrolyte management: hypophosphatemia synonyms, electrolyte management: hypophosphatemia antonyms - FreeThesaurus.com
Synonyms for electrolyte management: hypophosphatemia in Free Thesaurus. Antonyms for electrolyte management: hypophosphatemia. 38 synonyms for management: administration, control, rule, government, running, charge, care, operation, handling, direction, conduct, command, guidance.... What are synonyms for electrolyte management: hypophosphatemia?
https://www.freethesaurus.com/electrolyte+management%3A+hypophosphatemia
Idiopathic Renal Hypophosphataemia: Oral Phosphate Reverses Abnormalities in Muscle | Clinical Science | Portland PressIdiopathic Renal Hypophosphataemia: Oral Phosphate Reverses Abnormalities in Muscle | Clinical Science | Portland Press
JM Land, DJ Taylor, GJ Kemp, GK Radda, B Rajagopalan; Idiopathic Renal Hypophosphataemia: Oral Phosphate Reverses Abnormalities in Muscle. Clin Sci (Lond) 1 March 1992; 82 (s26): 26P. doi: https://doi.org/10.1042/cs082026Pa. Download citation file:. ...
https://portlandpress.com/clinsci/article-abstract/82/s26/26P/103727/Idiopathic-Renal-Hypophosphataemia-Oral-Phosphate
Evolution of metabolic rates in amniotes (empirical evidence for extant species and inferences using bone histology for extinct...
Evolution of metabolic rates in amniotes (empirical evidence for extant species and inferences using bone histology for extinct ones ...
http://www.college-de-france.fr/site/armand-de-ricqles/symposium-2010-06-16-14h00.htm
Bone Histology, Buch. Christian Crowder - ReadRateBone Histology, Buch. Christian Crowder - ReadRate
Bone Histology von Christian Crowder und Buchbewertungen gibt es auf ReadRate.com. Bücher können hier direkt online erworben werden.
http://readrate.com/deu/books/bone-histology
Part II: Metabolic bone disease: Recent developments in the pathogenesis of rickets, osteomalacia and age-related osteoporosisPart II: Metabolic bone disease: Recent developments in the pathogenesis of rickets, osteomalacia and age-related osteoporosis
ABSTRACT. The term metabolic bone disease encompasses an unrelated group of systemic conditions that impact on skeletal collagen and mineral metabolism. Their asymptomatic progression leads to advanced skeletal debilitation and late clinical manifestation. This article provides a brief overview of advances in the understanding of the pathogenesis of rickets, osteomalacia and age-related osteoporosis.. ...
http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1681-150X2009000100012&lng=en&nrm=iso
A Repeated Study of KRN23 in Adults With X-Linked Hypophosphatemia - Full Text View - ClinicalTrials.govA Repeated Study of KRN23 in Adults With X-Linked Hypophosphatemia - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
https://clinicaltrials.gov/ct2/show/NCT01340482?recr=Open&cond=%22Rickets%22&rank=12
Download Clinical aspects of metabolic bone disease; PDF EPUB FB2 MOBI
From the author of the popular Clinical Chemistry medical student textbook. Although there are many competing texts on clinical chemistry, the vast majority concentrate on the technology; this book concentrates on the clinical. Ideally suited for preparat.
https://bocarigiho.ogmaexpo.com/clinical-aspects-of-metabolic-bone-disease-book-35768fs.php
Renal osteodystrophy and clinical outcomes: data from the Brazilian Registry of Bone Biopsies - REBRABO.Renal osteodystrophy and clinical outcomes: data from the Brazilian Registry of Bone Biopsies - REBRABO.
CONCLUSION: Hospitalization or death was not influenced by the type of RO, Al accumulation, or TMV classification. An elevated prevalence of osteoporosis and Al accumulation was detected. PMID: 32756862 [PubMed - in process]...
https://medworm.com/811417401/renal-osteodystrophy-and-clinical-outcomes-data-from-the-brazilian-registry-of-bone-biopsies-rebr/
The Slow TwitchThe Slow Twitch
A gang of us used to play Loosers Softball every Memorial Day. We neede two ringers - guys who could actually get the ball over the plate. the rest of the teams were made up of people who couldnt run, pitch, hit, catch, or throw. You got as many swings as it took to hit the ball. Or if you got tired of swinging, you could take the base. If you could actually get under a ball and catch it, even if it bounced out of your glove, it counted. But the runner still got to stay on base. The only way you could actually be put out is if you knocked over someones beer. And if you tried keeping score, you were sent back to the house to get more beer, and no one would tell you what happened while you were gone. Then the Emericks started bringing the toxic waste margaritas and other people wanted to actually USE the diamond and the game sorta fizzled.. ReplyDelete ...
https://murrbrewster.blogspot.com/2011/05/slow-twitch.html
Round-Shaped Iliac Bones Causes & Reasons - SymptomaRound-Shaped Iliac Bones Causes & Reasons - Symptoma
Round-Shaped Iliac Bones Symptom Checker: Possible causes include Skeletal Dysplasia. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
https://www.symptoma.com/en/ddx/round-shaped-iliac-bones
Bone biopsyBone biopsy
Expect high-quality attention and the newest technology for bone biopsy with this certified specialist in Nuevo Laredo at low-prices
https://www.medicaltourismex.com/specialties/orthopedist/nuevo-laredo-clinic/procedures/bone-biopsy
CRYSVITA (burosumab-twza) - Official Site for Healthcare ProfessionalsCRYSVITA (burosumab-twza) - Official Site for Healthcare Professionals
CRYSVITA is the only FDA-approved therapy indicated for the treatment of X-linked hypophosphatemia (XLH) in adult and pediatric patients 6 months of age and older.
https://www.crysvita.com/hcp/
Column Fridus Steijlen: Chaos in het hoofd - KITLVColumn Fridus Steijlen: Chaos in het hoofd - KITLV
Vrijdagavond 15 juni was de (voorlopig?) laatste voorstelling van Westerling; een broederstrijd van theatergroep DeltaDua. Plaats van handeling was de Theaterkerk in Bemmel. In zeker opzicht het hol van de leeuw. De Molukse gemeenschap in Bemmel bestaat immers uit nazaten van de Molukse mannen die als commando onder Westerling hebben gediend. Slechts een paar van deze baretten is nog in leven. Oom Zefnath Patty bijvoorbeeld. Hij was aanwezig bij de voorstelling. En dan is er ook oom Daan Pattipeilohy die helaas vanwege gezondheidsredenen afwezig was. Ik mocht een inleiding houden en het nagesprek doen.. Foto: Jaïr Pattipeilohy. Lees meer.. ...
https://www.kitlv.nl/column-fridus-steijlen-chaos-het-hoofd/
OsteomalaciaOsteomalacia
... in children is known as rickets, and because of this, use of the term "osteomalacia" is often restricted to the ... Osteomalacia is a generalized bone condition in which there is inadequate mineralization of the bone. Many of the effects of ... Osteomalacia is derived from Greek: osteo- which means "bone", and malacia which means "softness". In the past, the disease was ... Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to ...
https://en.wikipedia.org/wiki/Osteomalacia
Oncogenic osteomalaciaOncogenic osteomalacia
... , also known as oncogenic hypophosphatemic osteomalacia, is an uncommon disorder resulting in increased ... Tumor-induced osteomalacia is usually referred to as a paraneoplastic phenomenon, however, the tumors are usually benign and ... This tumor may cause tumor-induced osteomalacia, a paraneoplastic syndrome, by the secretion of FGF23, which has phosphaturic ... Chong WH, Molinolo AA, Chen CC, Collins MT (June 2011). "Tumor-induced osteomalacia". Endocrine-Related Cancer. 18 (3): R53-R77 ...
https://en.wikipedia.org/wiki/Oncogenic_osteomalacia
Axial osteomalaciaAxial osteomalacia
... is a rare osteosclerotic disorder characterized by axial skeleton pain, coarsening of the trabecular bone ... Whyte MP, Fallon MD, Murphy WA, Teitelbaum SL (December 1981). "Axial osteomalacia. Clinical, laboratory and genetic ...
https://en.wikipedia.org/wiki/Axial_osteomalacia
Bone diseaseBone disease
"Osteomalacia and Rickets". The Lecturio Medical Concept Library. Retrieved 27 August 2021. "Osteomyelitis". The Lecturio ... Osteogenesis imperfecta Osteomalacia Osteomyelitis Osteopenia Osteopetrosis Osteoporosis Porotic hyperostosis Primary ...
https://en.wikipedia.org/wiki/Bone_disease
BoneBone
Osteomalacia is a painful softening of adult bone caused by severe vitamin D deficiency. Osteogenesis imperfecta ... "Osteomalacia and Rickets". The Lecturio Medical Concept Library. Retrieved 26 August 2021. "Osteogenesis Imperfecta". The ...
https://en.wikipedia.org/wiki/Bone
X-linked hypophosphatemiaX-linked hypophosphatemia
"Osteomalacia and Rickets". The Lecturio Medical Concept Library. Retrieved 24 August 2021. Silva S, Jeanty P (1999-06-07). " ... X-linked hypophosphatemia (XLH) is an X-linked dominant form of rickets (or osteomalacia) that differs from most cases of ... Autosomal dominant hypophosphatemic rickets Hypophosphatemia Tumor-induced osteomalacia Online Mendelian Inheritance in Man ( ... osteomalacia/odontomalacia). The prevalence of the disease is 1 in 20,000. X-linked hypophosphatemia may be lumped in with ...
https://en.wikipedia.org/wiki/X-linked_hypophosphatemia
Bone decalcificationBone decalcification
Hutchison, Florence (1992). "Osteomalacia and rickets". Seminars in Nephrology. 12 (2): 127-45. PMID 1561493. Callis, Gyle ( ... can cause diseases such as osteomalacia. Since calcium-rich bones are exceedingly difficult to study, scientists use bone ...
https://en.wikipedia.org/wiki/Bone_decalcification
Bone painBone pain
Hazzazi MA, Alzeer I, Tamimi W, Al Atawi M, Al Alwan I (2013). "Clinical presentation and etiology of osteomalacia/rickets in ... However, in certain diseases, the endosteal and haversian nerve supply seems to play an important role, e.g. in osteomalacia, ... Osteomalacia/rickets in adolescents. Osteopetrosis. Osteosarcoma. Rickets. Septic arthritis, a severe infection of the joint ...
https://en.wikipedia.org/wiki/Bone_pain
Teodora KrajewskaTeodora Krajewska
Krajewska was particularly interested in osteomalacia. She published a detailed article about it in 1900, claiming, on the ... for the supposedly endemic osteomalacia. In 1901, Krajewska was moved to Sarajevo, with Jadwiga Olszewska replacing her in ...
https://en.wikipedia.org/wiki/Teodora_Krajewska
József MarekJózsef Marek
"Further studies of rickets and osteomalacia. 2". CAB Direct. Retrieved December 31, 2019. "Studies of rickets and related bone ... 1" [Further studies of rickets and osteomalacia. 1]. Archiv für wissenschaftliche und praktische Tierheilkunde (in German). 73 ... 2" [Further studies of rickets and osteomalacia. 2]. Archiv für wissenschaftliche und praktische Tierheilkunde (in German). 73 ... "Further studies of rickets and osteomalacia. 1". CAB Direct. Retrieved December 31, 2019. " ...
https://en.wikipedia.org/wiki/József_Marek
Saber shinSaber shin
It can be due to osteomalacia.[citation needed] The bone looks like a boomerang from an early age. Saber refers to the tibia's ...
https://en.wikipedia.org/wiki/Saber_shin
Fibroblast growth factor 23Fibroblast growth factor 23
May 2001). "Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia". Proceedings of the ... Zadik Y, Nitzan DW (February 2012). "Tumor induced osteomalacia: a forgotten paraneoplastic syndrome?". Oral Oncology. 48 (2): ... such as the benign mesenchymal neoplasm phosphaturic mesenchymal tumor causing tumor-induced osteomalacia, a paraneoplastic ... "Immunohistochemical detection of FGF-23 protein in tumors that cause oncogenic osteomalacia". European Journal of Endocrinology ...
https://en.wikipedia.org/wiki/Fibroblast_growth_factor_23
Paraneoplastic syndromeParaneoplastic syndrome
Zadik Y, Nitzan DW (February 2012). "Tumor induced osteomalacia: a forgotten paraneoplastic syndrome?". Oral Oncology. 48 (2): ... tumor-induced osteomalacia, Stauffer syndrome, Neoplastic fever, and thymoma-associated multiorgan autoimmunity. Rheumatologic ...
https://en.wikipedia.org/wiki/Paraneoplastic_syndrome
John Chalmers (surgeon)John Chalmers (surgeon)
Osteomalacia - a common disease in elderly women. JBJS 49-B (1967), 403-423 Peripheral compression lesions of the ulnar nerve. ...
https://en.wikipedia.org/wiki/John_Chalmers_(surgeon)
HypophosphatasiaHypophosphatasia
Osteomalacia results in painful feet due to poor healing of metatarsal stress fractures. Discomfort in the thighs or hips due ... Vitamin D sterols and mineral supplements, traditionally used for rickets or osteomalacia, should not be used unless there is a ... Neonates who manage to survive suffer increasing respiratory compromise due to softening of the bones (osteomalacia) and ... Some stillborn skeletons show almost no mineralization; others have marked undermineralization and severe osteomalacia. ...
https://en.wikipedia.org/wiki/Hypophosphatasia
Malnutrition in South AfricaMalnutrition in South Africa
Kaneshiro, Neil K. "Rickets Osteomalacia in children; Vitamin D Deficiency; Renal Rickets; Hepatic Rickets". Vorvick, Linda J ...
https://en.wikipedia.org/wiki/Malnutrition_in_South_Africa
Intestinal bypassIntestinal bypass
A few cases of osteomalacia were reported. Fatigue is common after the surgery due to the malabsorption of nutrients. Kidney ...
https://en.wikipedia.org/wiki/Intestinal_bypass
Judson Sykes BuryJudson Sykes Bury
Bury, J. S. (2 February 1884). "A Case of Osteomalacia in a Child". Br Med J. 1 (1205): 213-214. doi:10.1136/bmj.1.1205.213. ...
https://en.wikipedia.org/wiki/Judson_Sykes_Bury
Bone remodeling periodBone remodeling period
"Only dynamics in osteoporosis and in osteomalacia." Thomas, Springfield, Illinois - 1966. Martınez-Gonzalez, JM, et al. ...
https://en.wikipedia.org/wiki/Bone_remodeling_period
Renal osteodystrophyRenal osteodystrophy
Retrieved 2021-03-12.{{cite web}}: CS1 maint: url-status (link) "Osteomalacia and Rickets". The Lecturio Medical Concept ... osteoporosis osteopenia osteomalacia brown tumor should be considered as the top-line diagnosis if a mass-forming lesion is ... osteomalacia, decreased turnover and abnormal mineralization; 4) adynamic, decreased turnover and acellularity; and, 5) mixed, ...
https://en.wikipedia.org/wiki/Renal_osteodystrophy
Laura SandemanLaura Sandeman
" "Dr Laura Sandeman", The Times, 23 February 1929 Sandeman, Laura Stewart (1903). "Six cases of osteomalacia : five in aged ...
https://en.wikipedia.org/wiki/Laura_Sandeman
Vitamin D deficiencyVitamin D deficiency
It can also worsen osteomalacia and osteoporosis in adults, increasing the risk of bone fractures. Muscle weakness is also a ... Dunnigan MG, Henderson JB (November 1997). "An epidemiological model of privational rickets and osteomalacia". The Proceedings ...
https://en.wikipedia.org/wiki/Vitamin_D_deficiency
UltragenyxUltragenyx
In 2020 the drug was approved to treat tumor-induced osteomalacia. Triheptanoin (brand name Dojolvi) a purified medium-chain ... "Crysvita Approved for Treatment of Tumor-Induced Osteomalacia". MPR. 2020-06-22. Retrieved 2022-02-04. "FDA Greenlights ...
https://en.wikipedia.org/wiki/Ultragenyx
Vitamin DVitamin D
... the childhood form of osteomalacia). Vitamin D supplements are given to treat or to prevent osteomalacia and rickets. The ... Although rickets and osteomalacia are now rare in the UK, outbreaks have happened in some immigrant communities in which ... Osteomalacia is a disease in adults that results from vitamin D deficiency. Characteristics of this disease are softening of ... Osteomalacia is usually present when 25-hydroxyvitamin D levels are less than about 10 ng/mL. Although the effects of ...
https://en.wikipedia.org/wiki/Vitamin_D
Lactase persistenceLactase persistence
Increased calcium absorption helps to prevent rickets and osteomalacia. A hypothesis specific to arid climate was proposed: ...
https://en.wikipedia.org/wiki/Lactase_persistence
March fractureMarch fracture
Consideration should always be given to osteoporosis and osteomalacia. Cavus feet are a risk factor for march fracture. ...
https://en.wikipedia.org/wiki/March_fracture
Sima SamarSima Samar
She also has drawn attention to the fact that many women in Afghanistan suffer from osteomalacia, a softening of the bones, due ... Wearing the burqa reduces exposure to sunlight and aggravates the situation for women suffering from osteomalacia. Samar is one ... Minisola, Salvatore (January 5, 2021). "Osteomalacia and Vitamin D Status: A Clinical Update 2020". JBMR Plus. 5 (1): e10447. ...
https://en.wikipedia.org/wiki/Sima_Samar
Elsie DalyellElsie Dalyell
Dalyell, Elsie Jean; Chick, Harriet (1921). Hunger - osteomalacia in Vienna, 1920 : its relation to diet. London: The Lancet. " ...
https://en.wikipedia.org/wiki/Elsie_Dalyell
Siegmund HaddaSiegmund Hadda
... osteomalacia; "Sufferers who were unable to stand up." X-rays showed the so-called "transformation zones" as described and ...
https://en.wikipedia.org/wiki/Siegmund_Hadda
OsteoporosisOsteoporosis
Higher cadmium exposure results in osteomalacia (softening of the bone). Soft drinks: Some studies indicate soft drinks (many ... or osteomalacia in renal osteodystrophy. However, radiography is relatively insensitive to detection of early disease and ...
https://en.wikipedia.org/wiki/Osteoporosis
Osteomalacia: MedlinePlus Medical EncyclopediaOsteomalacia: MedlinePlus Medical Encyclopedia
Osteomalacia is softening of the bones. It most often occurs because of a problem with vitamin D, which helps your body absorb ... Osteomalacia is softening of the bones. It most often occurs because of a problem with vitamin D, which helps your body absorb ... Rickets and osteomalacia. In Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. ... Osteomalacia and rickets. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020: ...
https://medlineplus.gov/ency/article/000376.htm
Browsing WHA28 by Subject OsteomalaciaBrowsing WHA28 by Subject "Osteomalacia"
Prevención del raquitismo, la osteomalacia y la osteoporosis  Asamblea Mundial de la Salud, 28 (‎Organización Mundial de la ... Prevención de la osteomalacia y la osteoporosis: proyecto de resolución presentado por las delegaciones de Fiji, Israel y Japón ...
https://apps.who.int/iris/handle/10665/89616/browse?authority=Osteomalacia&type=mesh
Osteomalacia: Causes, symptoms, diagnosis, treatment, and moreOsteomalacia: Causes, symptoms, diagnosis, treatment, and more
Learn about what causes it and the differences between osteomalacia, osteoporosis, and rickets. ... Osteomalacia is a disease that leads to softening of the bones. ... The symptoms of osteomalacia include:. *pain in the legs, upper ... Osteomalacia. (2016). https://rarediseases.info.nih.gov/diseases/7285/osteomalacia. *. Osteomalacia and rickets. (n.d.). https ... Osteomalacia is also known as bone softening. It is a condition in which new bone does not harden the way it should after ...
https://www.medicalnewstoday.com/articles/osteomalacia
Browsing by Subject OsteomalaciaBrowsing by Subject "Osteomalacia"
Prevención del raquitismo, la osteomalacia y la osteoporosis  Asamblea Mundial de la Salud, 28 (‎Organización Mundial de la ... Prevención de la osteomalacia y la osteoporosis: proyecto de resolución presentado por las delegaciones de Fiji, Israel y Japón ...
https://extranet.who.int/iris/restricted/browse?authority=Osteomalacia&type=mesh
OsteomalaciaOsteomalacia
... , Raquitismo do adulto, Osteomalacia NE, Osteomalacia. Spanish. OSTEOMALACIA, Osteomalacia no especificada, ... OSTEOMALACIA, Osteomalacia unspecified, Osteomalacia, unspecified, osteomalacia, osteomalacia (diagnosis), Adult rickets, ... Osteomalacia, Adult Rickets, Rickets, Adult, Osteomalacia unspecified (disorder), OM - Osteomalacia, Osteomalacia (disorder), ... osteomalacia no especificada (trastorno), osteomalacia (trastorno), osteomalacia, Osteomalacia. ...
https://fpnotebook.com/rheum/Bone/Ostmlc.htm
Tumor-Induced Osteomalacia: Increased Level of FGF-23 in a Patient with a Phosphaturic Mesenchymal Tumor at the Tibia...Tumor-Induced Osteomalacia: Increased Level of FGF-23 in a Patient with a Phosphaturic Mesenchymal Tumor at the Tibia...
... revealed a tumor mass located at the distal tibia leading to the diagnosis of tumor-induced osteomalacia (TIO). After resection ... S. M. Jan de Beur, "Tumor-induced osteomalacia," The Journal of the American Medical Association, vol. 294, no. 10, pp. 1260- ... W. H. Chong, A. A. Molinolo, C. C. Chen, and M. T. Collins, "Tumor-induced osteomalacia," Endocrine-Related Cancer, vol. 18, no ... M. D. Stone, C. Quincey, and D. J. Hosking, "A neuroendocrine cause of oncogenic osteomalacia," The Journal of Pathology, vol. ...
https://www.hindawi.com/journals/crie/2014/729387/
osteoclastic metastases to osteomalaciaosteoclastic metastases to osteomalacia
Woxikon / English dictionary / O / osteoclastic metastases to osteomalacia EN English dictionary from osteoclastic metastases ...
https://www.woxikon.com/en-osteoclastic%20metastases-to-osteomalacia
Free Insights - Tumor-induced Osteomalacia Market | Industry Analysis | Market Size | 2031Free Insights - Tumor-induced Osteomalacia Market | Industry Analysis | Market Size | 2031
Tumor-induced Osteomalacia Market report features an extensive study of the current landscape and the likely future potential ... Tumor-induced Osteomalacia: Pipeline Review, Developer Landscape and Competitive Insights, 2021-2031. * Lowest Price Guaranteed ...
https://www.rootsanalysis.com/reports/tumor-induced-osteomalacia-market/free-insights.html
Osteomalacia. | Henriettes Herbal HomepageOsteomalacia. | Henriette's Herbal Homepage
Osteomalacia.. This very peculiar condition is not so common in this country, as among the poorer classes in the old country. ...
https://www.henriettes-herb.com/eclectic/journals/elth/elth1908/06-osteomalacia.html
Bone Mineralization and Related Disorders: Practice Essentials, Vitamin D Metabolism, PathophysiologyBone Mineralization and Related Disorders: Practice Essentials, Vitamin D Metabolism, Pathophysiology
... tumor-induced osteomalacia, hypophosphatasia, McCune-Albright syndrome, and osteogenesis imperfecta with mineralization defect ... Tumor-Induced Osteomalacia. Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome with hypophosphatemia secondary to ... FGF-23 causes renal phosphate wasting in tumor-induced osteomalacia. Treatment is surgical removal of the tumor (if it can be ... 6] A down-regulation of 25-hydroxylation by phenobarbital may explain, at least in part, the increased risk of osteomalacia, ...
https://www.medscape.com/answers/985766-197874/how-is-familial-hypophosphatemia-treated
IMSEAR at SEARO: Oncogenic osteomalacia.
Jacob JJ, Finny P, Thomas M, Thomas N, John M. Oncogenic osteomalacia. Journal of the Association of Physicians of India. 2007 ... Biochemical tests confirmed the initial clinical diagnosis of osteomalacia. Blood pool scanning revealed a focal hot spot on ...
https://imsear.searo.who.int/handle/123456789/90031?mode=full
Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. | Scholars@DukeSerum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. | [email protected]
25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. ... Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. Journal Article ( ... a defect in vitamin D metabolism might play a role in the pathogenesis of X-linked hypophosphatemic rickets and osteomalacia ( ...
https://scholars.duke.edu/display/pub752797
Osteomalacia - Health HeartyOsteomalacia - Health Hearty
Osteomalacia is a medical condition that results in the weakening of bones. This article provides some information about this ... Osteomalacia. Osteomalacia is a medical condition that results in the weakening of bones. This article provides some ... Osteomalacia refers to a disease wherein the bones become soft due to the lack of Vitamin D in ones body. The terms Osteo ... Though osteomalacia is a bone disorder, it is different from osteoporosis that is also related to weak bones and leads to bone ...
https://healthhearty.com/osteomalacia
Osteomalacia | Profiles RNS
"Osteomalacia" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Osteomalacia" by people in this website by year, and whether " ... Niemeier T, Leddy L, Bolster M, Chapin R. Insufficiency fracture associated with oncogenic osteomalacia. J Clin Rheumatol. 2013 ... Below are the most recent publications written about "Osteomalacia" by people in Profiles. ...
https://profiles.musc.edu/display/91613/
Osteomalacia Archives - Doctors GangOsteomalacia Archives - Doctors Gang
Vitamin D deficiency : Rickets and Osteomalacia. Diseases, Rickets and Osteomalacia / By Dr Noman Islam Nirob ...
https://www.doctorsgang.com/tag/osteomalacia/
Osteomalacia presenting as pain syndromes of uncertain etiology.<...
Osteomalacia presenting as pain syndromes of uncertain etiology. South Dakota medicine : the journal of the South Dakota State ... Osteomalacia presenting as pain syndromes of uncertain etiology. In: South Dakota medicine : the journal of the South Dakota ... Lal, Y., Nair, P., Lovrien, F., & Freeman, J. W. (2009). Osteomalacia presenting as pain syndromes of uncertain etiology. South ... Osteomalacia presenting as pain syndromes of uncertain etiology. / Lal, Yasir; Nair, Preetha; Lovrien, Fred et al. ...
https://utsouthwestern.pure.elsevier.com/en/publications/osteomalacia-presenting-as-pain-syndromes-of-uncertain-etiology
Frontiers | The burden of vitamin D deficiency in household members of children presenting with symptomatic vitamin D deficiencyFrontiers | The burden of vitamin D deficiency in household members of children presenting with symptomatic vitamin D deficiency
Biochemical osteomalacia was present in 72% of the maternal and 79% of the sibling cohorts. Mothers of infants had ... Biochemical osteomalacia was present in 72% of the maternal and 79% of the sibling cohorts. Mothers of infants had ... and biochemical osteomalacia [vitamin D deficiency and elevated alkaline phosphatase (ALP) and/or parathormone (PTH)] as per ... and biochemical osteomalacia [vitamin D deficiency and elevated alkaline phosphatase (ALP) and/or parathormone (PTH)] as per ...
https://www.frontiersin.org/articles/10.3389/fendo.2022.958422/full
Tumor-Induced Osteomalacia (TIO) Information - UltragenyxTumor-Induced Osteomalacia (TIO) Information - Ultragenyx
Tumor-Induced Osteomalacia (TIO). Tumor-Induced Osteomalacia (TIO). /*! elementor - v3.6.4 - 13-04-2022 */ .elementor-widget- ... Tumor-induced Osteomalacia (TIO) "Its okay to say, Im having a really hard time, but within that to say, Are there little ... Tumor-induced Osteomalacia (TIO) "At 50 years old, I was a healthy, strong workaholic until everything changed." ... If you are aware of any tumor-induced osteomalacia (TIO) advocacy groups, please contact [email protected]. ...
https://ultrarareadvocacy.com/conditions-we-study/tumor-induced-osteomalacia-tio/
Instructions for Classifying Multiple Causes of Death, 2019 - Section IIInstructions for Classifying Multiple Causes of Death, 2019 - Section II
Since the decedent is less than 1 year of age at the time of death, code Osteomalacia, infantile. ...
https://www.cdc.gov/nchs/nvss/manuals/2019/2b-sectionii-2019.htm
FDA Approves Crysvita for Victims of Tumor-Induced OsteomalaciaFDA Approves Crysvita for Victims of Tumor-Induced Osteomalacia
and Kyowa Kirin Co., Ltd., was approved by the FDA for treating X-linked hypophosphatemia and tumor-induced osteomalacia. ... FDA Approves Crysvita for Victims of Tumor-Induced Osteomalacia. by Judy Ya-Hsuan Lin ... Excessive FGF23 diseases include X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia (TIO). XLH affects ... in Japan approved it for the treatment of FGF23-related hypophosphatemic rickets and osteomalacia. Europe received conditional ...
https://www.geneonline.com/fda-approves-crysvita-for-victims-of-tumor-induced-osteomalacia/
Stem Cell Treatment Osteomalacia in Delhi, India | Osteomalacia TherapyStem Cell Treatment Osteomalacia in Delhi, India | Osteomalacia Therapy
The correct treatment and cure is provided by Viezec in Stem Cell Treatment Osteomalacia in Delhi. We offer promising ... stem cell treatment for Osteomalacia, stem cell therapy for Osteomalacia, stem cell Osteomalacia Treatment, Osteomalacia stem ... Bill Favela underwent stem cell treatment for osteomalacia. I am a chronic patient of osteomalacia. Since I have osteomalacia, ... What is Osteomalacia?. Osteomalacia is the milder type of bone disorder, often related to softer bone tissue, typically as a ...
https://www.viezec.com/diseases-treated/orthopedic/stem-cell-treatment-osteomalacia/
Tumor-induced Osteomalacia Resources | CRYSVITA® (burosumab-twza) for TIOTumor-induced Osteomalacia Resources | CRYSVITA® (burosumab-twza) for TIO
Help patients understand tumor-induced osteomalacia (TIO) and connect with communities of support. ... osteomalacia. A softening and weakening of the bones in adults caused by deficiencies in vitamin D, calcium, or phosphate. In ... Osteomalacia and bone histomorphometry. Mineralization of the bone matrix (osteoid) is a critical step during bone formation. ... Osteomalacia is characterized by the following histomorphometric features: *Increased osteoid volume/bone volume ...
https://www.crysvita.com/tio/hcp/resources/
Hypocalcemia due to spontaneous infarction of parathyroid adenoma and osteomalacia in a patient with primary...
Dive into the research topics of Hypocalcemia due to spontaneous infarction of parathyroid adenoma and osteomalacia in a ... Hypocalcemia due to spontaneous infarction of parathyroid adenoma and osteomalacia in a patient with primary ...
https://okayama.pure.elsevier.com/en/publications/hypocalcemia-due-to-spontaneous-infarction-of-parathyroid-adenoma/fingerprints/?sortBy=alphabetically
Cadmium Toxicity: Clinical Assessment - Exposure History and Physical Examination | Environmental Medicine | ATSDRCadmium Toxicity: Clinical Assessment - Exposure History and Physical Examination | Environmental Medicine | ATSDR
osteomalacia,. *possibly hypertension,. *prostatic cancer, and. *proteinuria.. Chronic cadmium exposure has been reported to ...
https://www.atsdr.cdc.gov/csem/cadmium/Clinical-Assessment.html
osteomalacia and tension headaches have similar cause Archives - Holistic Health & Livingosteomalacia and tension headaches have similar cause Archives - Holistic Health & Living
Tag: osteomalacia and tension headaches have similar cause. - Aromatherapy, Food / Nutrition, Herbs, Pain management - ...
https://holistichealthliving.com/tag/osteomalacia-and-tension-headaches-have-similar-cause/
The Assistance Fund Opens New Program for Tumor-Induced Osteomalacia - The Assistance FundThe Assistance Fund Opens New Program for Tumor-Induced Osteomalacia - The Assistance Fund
RELEASE Financial Assistance From The Assistance Fund Now Available for Eligible People Living With Tumor-Induced Osteomalacia ... Tumor-induced osteomalacia is a rare disease that occurs when small tumors grow in the skin, muscles, or bones. TIO, sometimes ... "People living with tumor-induced osteomalacia not only face the challenge of an often debilitating diagnosis, they also must ... "The Assistance Fund is excited to announce the launch of our new Tumor-Induced Osteomalacia Financial Assistance Program," said ...
https://tafcares.org/newsroom/press-releases/the-assistance-fund-opens-new-program-for-tumor-induced-osteomalacia/
How Much Vitamin D Is Too Much Vitamin D? - NDTV FoodHow Much Vitamin D Is Too Much Vitamin D? - NDTV Food
2. Osteomalacia. It is the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of ... Rickets and Osteomalacia occurs at levels below 25 ng/mL in blood. Some researchers believe a more optimal range is anywhere ...
https://food.ndtv.com/food-drinks/how-much-vitamin-d-is-too-much-vitamin-d-2062241
7 Amazing Benefits of Vitamin D | Organic Facts7 Amazing Benefits of Vitamin D | Organic Facts
... and osteomalacia, controlling phosphate and calcium levels, and preventing bone fractures PAD and cancer. ... Osteomalacia is most often found in adults. The main symptoms of osteomalacia are an increase in bone fractures, a waddling ... Osteomalacia is treated with an oral dose of vitamin D and direct exposure to the sun. When there isnt an option for natural ... Osteomalacia means soft bones, and the disease of the same name refers to there being an issue with bones being weak or brittle ...
https://www.organicfacts.net/health-benefits/vitamins/health-benefits-of-vitamin-d.html
X-linked hypophosphatemic osteomalacia together with PHEX mutation delivering late inside Pakistan. | PPAR Signaling
X-linked hypophosphatemic osteomalacia together with PHEX mutation delivering late inside Pakistan.. Posted on November 22, ...
https://pparsignaling.com/x-linked-hypophosphatemic-osteomalacia-together-with-phex-mutation-delivering-late-inside-pakistan/
OsteoporosisBonesOncogenicHypophosphatemic rickets and osteomalaciaVitaminRickets in childrenAdultsDiagnosisTerm osteomalaciaHypophosphatemiaRenalMineralizationDisorderAdultDiseaseSymptomsSymptomaticTumorInsufficiencyNutritionalBiochemicalDescriptorSkeletalCollagenClinicalChildrenChronicIndiaBone lossDiagnoseDeficiencyPain
Osteoporosis6
  • More importantly, osteomalacia can look like weakening of the bones from osteoporosis on bone density testing. (medlineplus.gov)
  • Though osteomalacia is a bone disorder, it is different from osteoporosis that is also related to weak bones and leads to bone fractures. (healthhearty.com)
  • However, it is an imperative component that Stem Cell Treatment Osteomalacia and Osteoporosis or Osteopenia are usually very different from each other as Osteoporosis or Osteopenia is the diminishing or loss of formerly constructed bones, but Osteomalacia is the shortcoming in the bone-developing process itself. (viezec.com)
  • soft or brittle bones (osteoporosis, osteomalacia). (everydayhealth.com)
  • The conditions most commonly associated with ow levels of Vitamin D are osteoporosis, and osteomalacia. (ener-life.com)
  • Osteoporosis and osteomalacia both target the skeletal system. (ener-life.com)
Bones15
  • Osteomalacia is softening of the bones. (medlineplus.gov)
  • Rickets only develops in children whose bones are still growing, whereas osteomalacia can develop in people of all ages. (medicalnewstoday.com)
  • Rickets can cause deformed bones in children and limit their growth, while deformities usually only occur in severe cases of osteomalacia. (medicalnewstoday.com)
  • The most common symptoms of osteomalacia, such as sore bones and muscles, are vague enough that it can sometimes take 2-3 years to diagnose the condition. (medicalnewstoday.com)
  • Osteomalacia is a medical condition that results in the weakening of bones. (healthhearty.com)
  • Osteomalacia refers to a disease wherein the bones become soft due to the lack of Vitamin D in one's body. (healthhearty.com)
  • Tumor-induced osteomalacia is a rare disease that occurs when small tumors grow in the skin, muscles, or bones. (tafcares.org)
  • TIO, sometimes referred to as oncogenic osteomalacia, results in weakened bones and kidneys, as well as elevated levels of urine. (tafcares.org)
  • Osteomalacia means soft bones, and the disease of the same name refers to there being an issue with bones being weak or brittle. (organicfacts.net)
  • Osteomalacia causes soft and deformed bones, commonly due to insufficient phosphorus or vitamin D in the diet. (merckvetmanual.com)
  • Because it interferes with vitamin D metabolism, phenytoin can cause weakening of the bones (osteomalacia). (medicinenet.com)
  • Osteomalacia, on the other hand, is a softening of the bones leading to muscle weakness, and dull and aching pain in the back, pelvis, hips and legs. (ener-life.com)
  • Osteomalacia, a disease affecting adults by softening the bones. (lvdtraining.com)
  • In severe cases, vitamin D deficiency can also lead to osteomalacia, a condition characterized by weak and soft bones. (ziggiesocial.com)
  • Because vitamin D's active hormone, calcitriol, is particularly beneficial to bone health due to its role in aiding calcium and phosphorous absorption, a deficiency can lead to thin, brittle, misshapen bones, or the bone disease, osteomalacia (known as rickets in children). (antiaging-nutrition.com)
Oncogenic3
  • IMSEAR at SEARO: Oncogenic osteomalacia. (who.int)
  • Oncogenic osteomalacia. (who.int)
  • Niemeier T, Leddy L, Bolster M, Chapin R. Insufficiency fracture associated with oncogenic osteomalacia. (musc.edu)
Hypophosphatemic rickets and osteomalacia3
  • Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. (duke.edu)
  • In order to determine whether a defect in vitamin D metabolism might play a role in the pathogenesis of X-linked hypophosphatemic rickets and osteomalacia (XLH), we compared the serum 1,25-dihydroxyvitamin D [1,25(OH)2D] level in 52 normal subjects and 37 patients with XLH. (duke.edu)
  • The Ministry of Health, Labor and Welfare (MHLW) in Japan approved it for the treatment of FGF23-related hypophosphatemic rickets and osteomalacia. (geneonline.com)
Vitamin13
  • Eating a diet rich in vitamin D and calcium and getting sufficient exposure to sunlight can help prevent osteomalacia due to vitamin D deficiency. (medlineplus.gov)
  • To prevent rickets or osteomalacia in children, experts recommend daily doses of 600 IU vitamin D and dietary calcium in pregnant people and 400 IU daily in infants from birth. (medicalnewstoday.com)
  • Vitamin D deficiency can result in symptomatic osteomalacia which may cause bone pain and muscle weakness. (elsevier.com)
  • Investigate the prevalence of vitamin D deficiency and biochemical osteomalacia in the mothers and siblings of children presenting with symptomatic vitamin D deficiency. (frontiersin.org)
  • 30nmol/L] and biochemical osteomalacia [vitamin D deficiency and elevated alkaline phosphatase (ALP) and/or parathormone (PTH)] as per clinical guidelines. (frontiersin.org)
  • Osteomalacia is the milder type of bone disorder, often related to softer bone tissue, typically as a result of vitamin D deficiency. (viezec.com)
  • The health benefits of vitamin D, also known as calciferol, include curing rickets, the treatment of osteomalacia, protection against peripheral arterial disease (PAD), slowing the progression of cancer, preventing bone fractures, and treating rachitic rosary. (organicfacts.net)
  • The diseases caused by vitamin D deficiency are osteomalacia and rickets. (organicfacts.net)
  • Dr. Holick describes the link between vitamin D and osteomalacia. (empowher.com)
  • Osteomalacia And Vitamin D, What Is The Connection? (empowher.com)
  • Severe vitamin D deficiency causes rickets in children and osteomalacia in adults. (oregonstate.edu)
  • A lack of vitamin D can lead to bone deformities such as rickets in children, and bone pain caused by a condition called osteomalacia in adults. (revolverdeblake.com)
  • In its proposed local coverage determination (LCD), the Medicare carrier indicates that it would cover Vitamin D testing only for patients with chronic kidney disease, osteomalacia, hypercalcemia, and rickets. (darkdaily.com)
Rickets in children1
  • However, its deficiency can cause rickets in children and osteomalacia in adults. (organicfacts.net)
Adults3
  • Reduced bone mineralization (osteomalacia) affects adults and children and children additionally develop the growth plate disorder rickets ( 11 ). (frontiersin.org)
  • Osteomalacia is most often found in adults. (organicfacts.net)
  • 11(4) children and osteomalacia in adults. (who.int)
Diagnosis4
  • FGF-23 levels were significantly increased, and total body magnetic resonance imaging (MRI) revealed a tumor mass located at the distal tibia leading to the diagnosis of tumor-induced osteomalacia (TIO). (hindawi.com)
  • Biochemical tests confirmed the initial clinical diagnosis of osteomalacia. (who.int)
  • People living with tumor-induced osteomalacia not only face the challenge of an often debilitating diagnosis, they also must grapple with financial barriers to critical treatment. (tafcares.org)
  • Combined with unbearable bone pain, spontaneous fractures, changes in laboratory markers and the result of ECT and other radiographic findings, the diagnosis of Fanconi's syndrome with osteomalacia was established. (qxmd.com)
Term osteomalacia2
  • These images are a random sampling from a Bing search on the term "Osteomalacia. (fpnotebook.com)
  • In the case of children, it is commonly referred to as rickets and the term osteomalacia is used only in the case of the adult form of the disease. (healthhearty.com)
Hypophosphatemia2
  • Tumor-induced osteomalacia (TIO) is a rare, acquired paraneoplastic disorder characterized by a renal phosphate leak leading to hypophosphatemia and deranged bone turnover. (hindawi.com)
  • Excessive FGF23 diseases include X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia (TIO). (geneonline.com)
Renal1
  • Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition. (qxmd.com)
Mineralization1
  • One of the most important aspects of osteomalacia treatment is to make sure that a person gets the levels of nutrients they need to support the bone mineralization process. (medicalnewstoday.com)
Disorder1
  • Contact your health care provider if you have symptoms of osteomalacia, or if you think that you may be at risk for this disorder. (medlineplus.gov)
Adult2
  • Osteomalacia associated with adult Fanconi's syndrome: clinical and diagnostic features. (qxmd.com)
  • adult osteomalacia (M83. (icdcodesinfo.com)
Disease2
  • Tumor-induced osteomalacia (TIO) is a rare disease caused by tumors. (ultrarareadvocacy.com)
  • In horses, osteomalacia is sometimes known as bran disease, miller's disease , and " big head . (merckvetmanual.com)
Symptoms1
  • The main symptoms of osteomalacia are an increase in bone fractures, a waddling walk, and muscle weakness. (organicfacts.net)
Symptomatic2
  • Two patients with symptomatic osteomalacia after gastric bypass surgery are discussed. (elsevier.com)
  • FHH3 patients have heterozygous AP2S1 missense Arg15 mutations (p.Arg15Cys, p.Arg15His or p.Arg15Leu) with hypercalcaemia, which may be marked and symptomatic, and occasional hypophosphataemia and osteomalacia. (birmingham.ac.uk)
Tumor6
  • Tumor-induced Osteomalacia: Pipeline Rev. (rootsanalysis.com)
  • If you are aware of any tumor-induced osteomalacia (TIO) advocacy groups, please contact [email protected] . (ultrarareadvocacy.com)
  • ORLANDO, Fla., October 14, 2020 -The Assistance Fund, an independent charitable patient assistance organization that helps patients and families facing high medical out-of-pocket costs, today announced the launch of a new financial assistance program for people living with tumor-induced osteomalacia (TIO). (tafcares.org)
  • The Assistance Fund is excited to announce the launch of our new Tumor-Induced Osteomalacia Financial Assistance Program," said Mark P. McGreevy, President and CEO of The Assistance Fund. (tafcares.org)
  • Tumor-induced osteomalacia: rhinosinusal hemangiopericytoma]. (bvsalud.org)
  • Osteomalacia inducida por tumor: hemangiopericitoma rinosinusal. (bvsalud.org)
Insufficiency1
  • Supplement D insufficiency is the most notable purpose behind osteomalacia around the globe. (viezec.com)
Nutritional1
  • American countries is characterized by the increase (kwashiokor, nutritional marasmus) or specific lacks in the prevalence of overweight and obesity and a (hipovitaminosis A, scurvy, beriberi, rickets, reduction in the prevalence of under-weight, a deficit osteomalacia, pellagra, anemia), constituting in stature still persisting in high proportions3-7. (bvsalud.org)
Biochemical1
  • Biochemical osteomalacia was present in 72% of the maternal and 79% of the sibling cohorts. (frontiersin.org)
Descriptor1
  • Osteomalacia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
Skeletal1
  • Hypophosphatemic osteomalacia induced by low-dose adefovir therapy: focus on manifestations in the skeletal system and literature review. (qxmd.com)
Collagen1
  • When people have osteomalacia, the shell does not form fully, leaving the collagen soft and vulnerable. (medicalnewstoday.com)
Clinical1
  • It is seen that this bone resorption is more in Osteomalacia, as a result of some clinical issues, for example, hyperthyroidism or hypocalcemia and so on. (viezec.com)
Children1
  • In children, osteomalacia can occur simultaneously with rickets. (crysvita.com)
Chronic1
  • This case indicates that Fanconi's syndrome with osteomalacia can be acquired by a chronic hepatitis B patient taking ADV at a conventional dosage of 10 mg/day. (qxmd.com)
India1
  • People are searching for Stem Cell Treatment for Osteomalacia in Delhi, India, but can't seem to find the best Osteomalacia Treatment hospitals at an affordable price. (viezec.com)
Bone loss1
Diagnose1
  • However, once a doctor suspects osteomalacia, several different tests can help them diagnose it. (medicalnewstoday.com)
Deficiency1
  • As osteomalacia progresses, you may make bone torment and muscle deficiency. (viezec.com)
Pain3
  • Osteomalacia presenting as pain syndromes of uncertain etiology. (elsevier.com)
  • Dive into the research topics of 'Osteomalacia presenting as pain syndromes of uncertain etiology. (elsevier.com)
  • We report a case of low-dose ADV-induced hypophosphatemic osteomalacia that initially presented as diffuse musculoskeletal pain. (qxmd.com)