Neoplasms, Connective Tissue
Hypophosphatemia, Familial
An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.
Rickets
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Mesenchymoma
Hydroxycholecalciferols
Hemangiopericytoma
A tumor composed of spindle cells with a rich vascular network, which apparently arises from pericytes, cells of smooth muscle origin that lie around small vessels. Benign and malignant hemangiopericytomas exist, and the rarity of these lesions has led to considerable confusion in distinguishing between benign and malignant variants. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1364)
Paraneoplastic Syndromes
Familial Hypophosphatemic Rickets
Fanconi Syndrome
A hereditary or acquired form of generalized dysfunction of the PROXIMAL KIDNEY TUBULE without primary involvement of the KIDNEY GLOMERULUS. It is usually characterized by the tubular wasting of nutrients and salts (GLUCOSE; AMINO ACIDS; PHOSPHATES; and BICARBONATES) resulting in HYPOKALEMIA; ACIDOSIS; HYPERCALCIURIA; and PROTEINURIA.
Bone and Bones
Aluminum
Renal Osteodystrophy
Osteitis Fibrosa Cystica
Vitamin D
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
Hypophosphatasia
A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
Phosphorus
Alkaline Phosphatase
Vitamin D Deficiency
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Fibroblast Growth Factors
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
Primidone
Calcification, Physiologic
Glucaric Acid
Ergocalciferols
Hyperparathyroidism
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
PHEX Phosphate Regulating Neutral Endopeptidase
A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.
Fibrous Dysplasia of Bone
Calcitriol
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Acidosis, Renal Tubular
A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
Femoral Neck Fractures
Phenytoin
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
Genetic Diseases, X-Linked
Parathyroid Hormone
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Strontium
Lymphangiectasis, Intestinal
Hypocalcemia
Fractures, Spontaneous
Cholecalciferol
Calcifediol
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Chondroma
Hyperparathyroidism, Secondary
Osteoporosis
Sodium-Phosphate Cotransporter Proteins, Type IIc
Gastrectomy
Bone Matrix
Anemia, Refractory
Bisphosphonate-Associated Osteonecrosis of the Jaw
Calcium Metabolism Disorders
Whole Body Imaging
Minerals
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Malabsorption Syndromes
Purpura, Hyperglobulinemic
Osteocytes
Iatrogenic Disease
Bone Density
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Renal Dialysis
Parathyroid Glands
Bone Remodeling
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Uremia
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
Bone Density Conservation Agents
Celiac Disease
Liver Cirrhosis, Biliary
FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cirrhosis involves the destruction of small intra-hepatic bile ducts and bile secretion. Secondary biliary cirrhosis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.
Osteoblasts
Soft Tissue Neoplasms
Kidney
Calcium, Dietary
Phenobarbital
Tibia
Epilepsy
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Osteomalacia
Extracellular Matrix Proteins
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
Biopsy
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Biochemical indices of osteomalacia in pregnant Asian immigrants in Britain. (1/293)
Serum calcium, phosphate and alkaline phosphatase, and urinary calcium excretion were examined during the second trimester of uncomplicated normal pregnancy in Asian immigrants to Britain and in local Caucasians. The mean serum calcium was significantly lower in Asians than in Caucasians, and the mean serum alkaline phosphatase was significantly higher in Asians. The geometric mean of the urinary calcium excretion was highly significantly lower in Asians than in Caucasians. The variances of the serum calcium, serum alkaline phosphatase, and urine calcium excretion did not differ significantly in the two populations. This indicates that there is a shift in values of immigrant Asians as a group compared with Caucasians. A comparison with figures obtained on normal nonpregnant persons of both suggests that the shift is not an inherent feature of the Asian population. (+info)Use of ultrasonography in the diagnosis of osteomalacia: preliminary results on experimental osteomalacia in the rat. (2/293)
This study was performed to investigate the ability of ultrasonographic technique to distinguish osteomalacia from normal bone with the same mineral content. Ten rats with experimentally induced osteomalacia (group A) and 12 control rats having similar body size and weight (group B) were studied. Histomorphometric analysis confirmed the presence of osteomalacia in two rats from group A and showed normally mineralized bone in two rats from group B. Whole body bone mineral density, measured by dual-energy x-ray absorptiometry, was similar in the two groups (86 +/- 6 mg/cm2 in group A and 89 +/- 4 mg/cm2 in group B). The velocity of the ultrasound beam in bone was measured by densitometer at the first caudal vertebra of each rat. The velocity was measured when the first peak of the waveform reached a predetermined minimum amplitude value (amplitude-dependent speed of sound) as well as at the lowest point of this curve before it reaches the predetermined minimum amplitude (first minimum speed of sound). Although the amplitude-dependent speed of sound was similar in the two groups (1381.9 +/- 11.8 m/s in group A and 1390.9 +/- 17.8 m/s in group B), the first minimum speed of sound was clearly different (1446.1 +/- 8.9 m/s in group A and 1503.3 +/- 10.9 m/s in group B; P < 0.001). This study shows that ultrasonography could be used to identify alterations in bone quality, such as osteomalacia, but further studies need to be carried out before this method can be introduced into clinical practice. (+info)Bone histology in patients with nephrotic syndrome and normal renal function. (3/293)
BACKGROUND: The prevalence of metabolic bone disease in patients with nephrotic syndrome (NS) at normal level of renal function remains uncertain. METHODS: To address this issue, we studied 30 patients (20 men and 10 women, mean age 27.3 +/- 11.7 years) with NS who had normal renal function (mean creatinine clearance 103 +/- 4 ml/min). We evaluated their serum calcium, phosphorus, alkaline phosphatase, immunoreactive parathyroid hormone (iPTH), vitamin D metabolites, urinary calcium, and skeletal survey. The extent of bone mineralization was analyzed by histomorphometric analysis of iliac crest bone biopsy specimens in all patients. The findings on bone histology were correlated with biochemical parameters. RESULTS: The mean duration of NS was 35.5 +/- 26.9 months, with a protein excretion of 7.3 +/- 3.2 g/24 hr and a serum albumin of 2.2 +/- 0.8 g/dl. Total serum calcium was 7.8 +/- 0.8 mg/dl, whereas ionized calcium was 5.7 +/- 0.7 mg/dl, phosphorus 3.2 +/- 1.2 mg/dl, and alkaline phosphatase 149 +/- 48.6 U/liter. Serum iPTH levels were normal in all except two patients. The mean serum 25-hydroxyvitamin D [25(OH)D] level was 3.9 +/- 1.2 ng/ml (normal 15 to 30 ng/ml), whereas 1,25-dihydroxyvitamin D was 24 +/- 4.7 pg/ml (normal 16 to 65). There was an inverse correlation between serum levels of 25(OH)D and the magnitude of proteinuria (r = -0.42, P < 0.05). The mean 24-hour urinary calcium excretion was 82 +/- 21 mg/day. The skeletal survey was normal in all patients. Bone histology was normal in 33.3% of the patients, whereas 56.7% had isolated osteomalacia (OSM), and 10% had an increased bone resorption in association with defective mineralization. The severity of OSM measured by mineralization lag time correlated linearly with the duration (r = 0.94, P < 0.0001) and the amount (r = 0.97, P < 0.0001) of proteinuria. All patients with NS for more than three years had histological changes. Patients with OSM had lower 25(OH)D and serum albumin as compared with those with normal histology (P < 0.005). Bone mineralization had no significant correlation with serum iPTH, divalent ions, or vitamin D levels. CONCLUSIONS: OSM is a frequent finding in adult patients with NS, even at a normal level of renal function. Its severity correlates with the amount and duration of proteinuria. (+info)Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. (4/293)
For adults, the 5-microg (200 IU) vitamin D recommended dietary allowance may prevent osteomalacia in the absence of sunlight, but more is needed to help prevent osteoporosis and secondary hyperparathyroidism. Other benefits of vitamin D supplementation are implicated epidemiologically: prevention of some cancers, osteoarthritis progression, multiple sclerosis, and hypertension. Total-body sun exposure easily provides the equivalent of 250 microg (10000 IU) vitamin D/d, suggesting that this is a physiologic limit. Sailors in US submarines are deprived of environmentally acquired vitamin D equivalent to 20-50 microg (800-2000 IU)/d. The assembled data from many vitamin D supplementation studies reveal a curve for vitamin D dose versus serum 25-hydroxyvitamin D [25(OH)D] response that is surprisingly flat up to 250 microg (10000 IU) vitamin D/d. To ensure that serum 25(OH)D concentrations exceed 100 nmol/L, a total vitamin D supply of 100 microg (4000 IU)/d is required. Except in those with conditions causing hypersensitivity, there is no evidence of adverse effects with serum 25(OH)D concentrations <140 nmol/L, which require a total vitamin D supply of 250 microg (10000 IU)/d to attain. Published cases of vitamin D toxicity with hypercalcemia, for which the 25(OH)D concentration and vitamin D dose are known, all involve intake of > or = 1000 microg (40000 IU)/d. Because vitamin D is potentially toxic, intake of >25 microg (1000 IU)/d has been avoided even though the weight of evidence shows that the currently accepted, no observed adverse effect limit of 50 microg (2000 IU)/d is too low by at least 5-fold. (+info)Is low plasma 25-(OH)vitamin D a major risk factor for hyperparathyroidism and Looser's zones independent of calcitriol? (5/293)
BACKGROUND: Recent reports suggest that calcitriol might not be the sole active metabolite of vitamin D and that plasma concentrations of 25-(OH)vitamin D (25OHD) are often abnormally low in hemodialysis patients. We have therefore evaluated plasma 25OHD as a risk factor for parathyroid hormone (PTH) hypersecretion and radiological bone disease. We carried out a cross-sectional study during the month of September in an Algerian dialysis center of 113 patients who were not taking supplements of alphacalcidol or calcitriol. METHODS: Plasma 25OHD, calcitriol, PTH, calcium, phosphate, bicarbonate, and aluminum were measured, and x-rays of the hands and pelvis were obtained for evaluation of subperiosteal resorption and Looser's zones. RESULTS: The median plasma 25OHD was 47.5 nmol/liter (range 2.5 to 170.0). Univariate analysis showed that plasma PTH was correlated positively with months on maintenance dialysis and negatively with plasma 25OHD, calcitriol, calcium, bicarbonate and aluminum, but not with that of phosphate. plasma 25OHD was positively correlated with calcium and calcitriol. Using multiple regression analysis, only plasma 25OHD (negative) and the duration on maintenance dialysis (positive) were independently linked to plasma PTH. The prevalence of isolated subperiosteal resorption (ISR) was 34%, and that of the combination of resorption with Looser's zones (CRLZ) was 9%; thus, only 57% of the patients had a normal x-ray appearance. These groups were comparable with regards to age, gender, and duration on dialysis. When the biochemical measurements of the patients with CRLZ were compared with those from patients without radiological lesions, plasma 25OHD was the only parameter to show a statistically significant difference, being significantly lower in the CRLZ group (26 +/- 18 vs. 57 nmol/liter, ANOVA, P < 0.004). Plasma 25OHD was also significantly lower in the ISR group (44, P < 0.05) than in the normal x-ray group, and plasma Ca (P < 0.003) and bicarbonate (P < 0.02) were lower. Logistical analysis showed that the presence of resorption was independently linked only with plasma PTH. Looser's zones and subperiosteal resorption were not seen in patients with plasma 25OHD of more than 40 (Looser's zones) and more than 100 nmol/liter (subperiosteal resorption). The optimal range for intact PTH in hemodialysis patients with mild aluminum overload is 10 to 25 pmol/liter. We found that plasma PTH was inappropriately high only when plasma 25OHD was less than 100 nmol/liter. With a plasma 25OHD of between 100 and 170 nmol/liter, hypercalcemia was present with a plasma PTH of less than 10 pmol/liter in only one case. CONCLUSIONS: This cross sectional study shows that low plasma 25OHD is a major risk factor for hyperparathyroidism and Looser's zones. In dialysis patients, we suggest that the plasma levels of 25OHD are maintained around the upper limit of the reference range of sunny countries. (+info)Bone scintigraphy in renal osteodystrophy. (6/293)
Bone scintigraphy with Tc-99m HEDP was performed in 30 patients on maintenance hemodialysis, and the results of quantitative analysis were compared with those of a normal group. To permit this comparison, elevated background activity due to the absence of renal radiotracer excretion was reduced by hemodialysis to levels found in the normals. Histologic proof of renal osteodystrophy had been obtained in all patients. The incidence of radiographic abnormalities was 46%, whereas abnormal scans were found in 25 patients (83%); skeletal lesions were also more pronounced and detected earlier. However, even when the scans appeared normal, the quantitative analysis showed increased skeletal activity in all patients. The total skeletal activity proved to be a good index of the severity of renal osteodystrophy and appeared dependent on both osteomalacia and hyperparathyroidism. These findings show that bone scintigraphy is a sensitive method to detect skeletal involvement in renal osteodystrophy. (+info)Increased bone strontium levels in hemodialysis patients with osteomalacia. (7/293)
BACKGROUND: In this study, we report on the association between increased bone strontium levels and the presence of osteomalacia in end-stage renal failure patients treated by hemodialysis. METHODS: We performed a histologic examination and determined the strontium content and strontium/calcium ratios in bone biopsies of 100 hemodialysis patients recruited from various centers all over the world. Aside from the bone strontium concentration, the bone aluminum content was assessed. The bone zinc concentration, a nonrelevant element for bone toxicity, was also measured. RESULTS: Bone strontium levels and bone strontium/calcium ratios were increased in subjects with osteomalacia when compared with those with the other types of renal osteodystrophy. Bone strontium and bone calcium levels correlated with each other. The slope of the linear regression curve correlating these parameters was much steeper in the osteomalacic group (Y = 2.22X - 120) as compared with the other types of renal osteodystrophy (Y = 0.52X - 5.7). Within the group of patients with osteomalacia, bone strontium levels also significantly correlated with the bone aluminum content (r = 0.72, P = 0.018). No such correlation was found for the other types of renal osteodystrophy. The bone zinc concentration of subjects with normal renal function did not differ significantly from the values noted for the various types of renal osteodystrophy taken as separate groups, nor could increased bone zinc concentrations be associated with a particular bone lesion. CONCLUSIONS: Our data demonstrate an association between osteomalacia and increased bone strontium concentrations in dialysis patients. Further studies are warranted to establish whether strontium plays either a primary, secondary, or contributive role in the development of the latter type of renal osteodystrophy. (+info)Use of quantitative ultrasonography in differentiating osteomalacia from osteoporosis: preliminary study. (8/293)
The aim of this work was to use ultrasonographic technology to differentiate osteoporosis from osteomalacia on the basis of different patterns of the graphic trace. Three patients with osteomalacia and three with osteoporosis, all with the same lumbar spine bone mineral density, were studied. The velocity of the ultrasound beam in bone was measured by a DBM Sonic 1,200/I densitometer at the proximal phalanges of the hands in all the patients. The ultrasound beam velocity was measured when the first peak of the waveform reached a predetermined minimum amplitude value (amplitude-dependent speed of sound) as well as at the lowest point prior to the first and second peaks, before they reached the predetermined minimum amplitude value (first and second minimum speeds of sound). The graphic traces were further analyzed by Fourier analysis, and both the main frequency (f0) and the width of the peak centered in the f0 (full width at half maximum) were measured. The first and second minimum speeds of sound were significantly lower in the patients with osteomalacia than in the osteoporosis group. The first minimum speed of sound was 2,169 +/- 73 m/s in osteoporosis and 1,983 +/- 61 m/s in osteomalacia (P < 0.0001); the second minimum peak speed of sound was 1,895 +/-59 m/s in osteoporosis and 1,748 +/- 38 m/s in osteomalacia (P < 0.0001). The f0 was similar in the two groups (osteoporosis, 0.85 +/- 0.14 MHz; osteomalacia, 0.9 +/- 0.22 MHz; P = 0.72), and the full width at half maximum was significantly higher in the osteomalacia patients (0.52 +/- 0.14 MHz) than in the osteoporosis patients (0.37 +/- 0.15 MHz) (P = 0.022). This study confirms that ultrasonography is a promising, noninvasive method that could be used to differentiate osteoporosis from osteomalacia, but further studies should be carried out before this method can be introduced into clinical practice. (+info)
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Osteomalacia
... in children is known as rickets, and because of this, use of the term "osteomalacia" is often restricted to the ... Osteomalacia is a generalized bone condition in which there is inadequate mineralization of the bone. Many of the effects of ... Osteomalacia is derived from Greek: osteo- which means "bone", and malacia which means "softness". In the past, the disease was ... Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to ...
Oncogenic osteomalacia
... , also known as oncogenic hypophosphatemic osteomalacia, is an uncommon disorder resulting in increased ... Tumor-induced osteomalacia is usually referred to as a paraneoplastic phenomenon, however, the tumors are usually benign and ... This tumor may cause tumor-induced osteomalacia, a paraneoplastic syndrome, by the secretion of FGF23, which has phosphaturic ... Chong WH, Molinolo AA, Chen CC, Collins MT (June 2011). "Tumor-induced osteomalacia". Endocrine-Related Cancer. 18 (3): R53-R77 ...
Axial osteomalacia
... is a rare osteosclerotic disorder characterized by axial skeleton pain, coarsening of the trabecular bone ... Whyte MP, Fallon MD, Murphy WA, Teitelbaum SL (December 1981). "Axial osteomalacia. Clinical, laboratory and genetic ...
Bone disease
"Osteomalacia and Rickets". The Lecturio Medical Concept Library. Retrieved 27 August 2021. "Osteomyelitis". The Lecturio ... Osteogenesis imperfecta Osteomalacia Osteomyelitis Osteopenia Osteopetrosis Osteoporosis Porotic hyperostosis Primary ...
Bone
Osteomalacia is a painful softening of adult bone caused by severe vitamin D deficiency. Osteogenesis imperfecta ... "Osteomalacia and Rickets". The Lecturio Medical Concept Library. Retrieved 26 August 2021. "Osteogenesis Imperfecta". The ...
X-linked hypophosphatemia
"Osteomalacia and Rickets". The Lecturio Medical Concept Library. Retrieved 24 August 2021. Silva S, Jeanty P (1999-06-07). " ... X-linked hypophosphatemia (XLH) is an X-linked dominant form of rickets (or osteomalacia) that differs from most cases of ... Autosomal dominant hypophosphatemic rickets Hypophosphatemia Tumor-induced osteomalacia Online Mendelian Inheritance in Man ( ... osteomalacia/odontomalacia). The prevalence of the disease is 1 in 20,000. X-linked hypophosphatemia may be lumped in with ...
Bone decalcification
Hutchison, Florence (1992). "Osteomalacia and rickets". Seminars in Nephrology. 12 (2): 127-45. PMID 1561493. Callis, Gyle ( ... can cause diseases such as osteomalacia. Since calcium-rich bones are exceedingly difficult to study, scientists use bone ...
Bone pain
Hazzazi MA, Alzeer I, Tamimi W, Al Atawi M, Al Alwan I (2013). "Clinical presentation and etiology of osteomalacia/rickets in ... However, in certain diseases, the endosteal and haversian nerve supply seems to play an important role, e.g. in osteomalacia, ... Osteomalacia/rickets in adolescents. Osteopetrosis. Osteosarcoma. Rickets. Septic arthritis, a severe infection of the joint ...
Teodora Krajewska
Krajewska was particularly interested in osteomalacia. She published a detailed article about it in 1900, claiming, on the ... for the supposedly endemic osteomalacia. In 1901, Krajewska was moved to Sarajevo, with Jadwiga Olszewska replacing her in ...
József Marek
"Further studies of rickets and osteomalacia. 2". CAB Direct. Retrieved December 31, 2019. "Studies of rickets and related bone ... 1" [Further studies of rickets and osteomalacia. 1]. Archiv für wissenschaftliche und praktische Tierheilkunde (in German). 73 ... 2" [Further studies of rickets and osteomalacia. 2]. Archiv für wissenschaftliche und praktische Tierheilkunde (in German). 73 ... "Further studies of rickets and osteomalacia. 1". CAB Direct. Retrieved December 31, 2019. " ...
Saber shin
It can be due to osteomalacia.[citation needed] The bone looks like a boomerang from an early age. Saber refers to the tibia's ...
Fibroblast growth factor 23
May 2001). "Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia". Proceedings of the ... Zadik Y, Nitzan DW (February 2012). "Tumor induced osteomalacia: a forgotten paraneoplastic syndrome?". Oral Oncology. 48 (2): ... such as the benign mesenchymal neoplasm phosphaturic mesenchymal tumor causing tumor-induced osteomalacia, a paraneoplastic ... "Immunohistochemical detection of FGF-23 protein in tumors that cause oncogenic osteomalacia". European Journal of Endocrinology ...
Paraneoplastic syndrome
Zadik Y, Nitzan DW (February 2012). "Tumor induced osteomalacia: a forgotten paraneoplastic syndrome?". Oral Oncology. 48 (2): ... tumor-induced osteomalacia, Stauffer syndrome, Neoplastic fever, and thymoma-associated multiorgan autoimmunity. Rheumatologic ...
John Chalmers (surgeon)
Osteomalacia - a common disease in elderly women. JBJS 49-B (1967), 403-423 Peripheral compression lesions of the ulnar nerve. ...
Hypophosphatasia
Osteomalacia results in painful feet due to poor healing of metatarsal stress fractures. Discomfort in the thighs or hips due ... Vitamin D sterols and mineral supplements, traditionally used for rickets or osteomalacia, should not be used unless there is a ... Neonates who manage to survive suffer increasing respiratory compromise due to softening of the bones (osteomalacia) and ... Some stillborn skeletons show almost no mineralization; others have marked undermineralization and severe osteomalacia. ...
Malnutrition in South Africa
Kaneshiro, Neil K. "Rickets Osteomalacia in children; Vitamin D Deficiency; Renal Rickets; Hepatic Rickets". Vorvick, Linda J ...
Intestinal bypass
A few cases of osteomalacia were reported. Fatigue is common after the surgery due to the malabsorption of nutrients. Kidney ...
Judson Sykes Bury
Bury, J. S. (2 February 1884). "A Case of Osteomalacia in a Child". Br Med J. 1 (1205): 213-214. doi:10.1136/bmj.1.1205.213. ...
Bone remodeling period
"Only dynamics in osteoporosis and in osteomalacia." Thomas, Springfield, Illinois - 1966. Martınez-Gonzalez, JM, et al. ...
Renal osteodystrophy
Retrieved 2021-03-12.{{cite web}}: CS1 maint: url-status (link) "Osteomalacia and Rickets". The Lecturio Medical Concept ... osteoporosis osteopenia osteomalacia brown tumor should be considered as the top-line diagnosis if a mass-forming lesion is ... osteomalacia, decreased turnover and abnormal mineralization; 4) adynamic, decreased turnover and acellularity; and, 5) mixed, ...
Laura Sandeman
" "Dr Laura Sandeman", The Times, 23 February 1929 Sandeman, Laura Stewart (1903). "Six cases of osteomalacia : five in aged ...
Vitamin D deficiency
It can also worsen osteomalacia and osteoporosis in adults, increasing the risk of bone fractures. Muscle weakness is also a ... Dunnigan MG, Henderson JB (November 1997). "An epidemiological model of privational rickets and osteomalacia". The Proceedings ...
Ultragenyx
In 2020 the drug was approved to treat tumor-induced osteomalacia. Triheptanoin (brand name Dojolvi) a purified medium-chain ... "Crysvita Approved for Treatment of Tumor-Induced Osteomalacia". MPR. 2020-06-22. Retrieved 2022-02-04. "FDA Greenlights ...
Vitamin D
... the childhood form of osteomalacia). Vitamin D supplements are given to treat or to prevent osteomalacia and rickets. The ... Although rickets and osteomalacia are now rare in the UK, outbreaks have happened in some immigrant communities in which ... Osteomalacia is a disease in adults that results from vitamin D deficiency. Characteristics of this disease are softening of ... Osteomalacia is usually present when 25-hydroxyvitamin D levels are less than about 10 ng/mL. Although the effects of ...
Lactase persistence
Increased calcium absorption helps to prevent rickets and osteomalacia. A hypothesis specific to arid climate was proposed: ...
March fracture
Consideration should always be given to osteoporosis and osteomalacia. Cavus feet are a risk factor for march fracture. ...
Sima Samar
She also has drawn attention to the fact that many women in Afghanistan suffer from osteomalacia, a softening of the bones, due ... Wearing the burqa reduces exposure to sunlight and aggravates the situation for women suffering from osteomalacia. Samar is one ... Minisola, Salvatore (January 5, 2021). "Osteomalacia and Vitamin D Status: A Clinical Update 2020". JBMR Plus. 5 (1): e10447. ...
Elsie Dalyell
Dalyell, Elsie Jean; Chick, Harriet (1921). Hunger - osteomalacia in Vienna, 1920 : its relation to diet. London: The Lancet. " ...
Siegmund Hadda
... osteomalacia; "Sufferers who were unable to stand up." X-rays showed the so-called "transformation zones" as described and ...
Osteoporosis
Higher cadmium exposure results in osteomalacia (softening of the bone). Soft drinks: Some studies indicate soft drinks (many ... or osteomalacia in renal osteodystrophy. However, radiography is relatively insensitive to detection of early disease and ...
Osteomalacia: MedlinePlus Medical Encyclopedia
Osteomalacia is softening of the bones. It most often occurs because of a problem with vitamin D, which helps your body absorb ... Osteomalacia is softening of the bones. It most often occurs because of a problem with vitamin D, which helps your body absorb ... Rickets and osteomalacia. In Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. ... Osteomalacia and rickets. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020: ...
Browsing WHA28 by Subject "Osteomalacia"
Osteomalacia: Causes, symptoms, diagnosis, treatment, and more
Learn about what causes it and the differences between osteomalacia, osteoporosis, and rickets. ... Osteomalacia is a disease that leads to softening of the bones. ... The symptoms of osteomalacia include:. *pain in the legs, upper ... Osteomalacia. (2016). https://rarediseases.info.nih.gov/diseases/7285/osteomalacia. *. Osteomalacia and rickets. (n.d.). https ... Osteomalacia is also known as bone softening. It is a condition in which new bone does not harden the way it should after ...
Browsing by Subject "Osteomalacia"
Osteomalacia
... , Raquitismo do adulto, Osteomalacia NE, Osteomalacia. Spanish. OSTEOMALACIA, Osteomalacia no especificada, ... OSTEOMALACIA, Osteomalacia unspecified, Osteomalacia, unspecified, osteomalacia, osteomalacia (diagnosis), Adult rickets, ... Osteomalacia, Adult Rickets, Rickets, Adult, Osteomalacia unspecified (disorder), OM - Osteomalacia, Osteomalacia (disorder), ... osteomalacia no especificada (trastorno), osteomalacia (trastorno), osteomalacia, Osteomalacia. ...
Tumor-Induced Osteomalacia: Increased Level of FGF-23 in a Patient with a Phosphaturic Mesenchymal Tumor at the Tibia...
... revealed a tumor mass located at the distal tibia leading to the diagnosis of tumor-induced osteomalacia (TIO). After resection ... S. M. Jan de Beur, "Tumor-induced osteomalacia," The Journal of the American Medical Association, vol. 294, no. 10, pp. 1260- ... W. H. Chong, A. A. Molinolo, C. C. Chen, and M. T. Collins, "Tumor-induced osteomalacia," Endocrine-Related Cancer, vol. 18, no ... M. D. Stone, C. Quincey, and D. J. Hosking, "A neuroendocrine cause of oncogenic osteomalacia," The Journal of Pathology, vol. ...
osteoclastic metastases to osteomalacia
Free Insights - Tumor-induced Osteomalacia Market | Industry Analysis | Market Size | 2031
Osteomalacia. | Henriette's Herbal Homepage
Bone Mineralization and Related Disorders: Practice Essentials, Vitamin D Metabolism, Pathophysiology
... tumor-induced osteomalacia, hypophosphatasia, McCune-Albright syndrome, and osteogenesis imperfecta with mineralization defect ... Tumor-Induced Osteomalacia. Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome with hypophosphatemia secondary to ... FGF-23 causes renal phosphate wasting in tumor-induced osteomalacia. Treatment is surgical removal of the tumor (if it can be ... 6] A down-regulation of 25-hydroxylation by phenobarbital may explain, at least in part, the increased risk of osteomalacia, ...
IMSEAR at SEARO: Oncogenic osteomalacia.
Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. | [email protected]
25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. ... Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. Journal Article ( ... a defect in vitamin D metabolism might play a role in the pathogenesis of X-linked hypophosphatemic rickets and osteomalacia ( ...
Osteomalacia - Health Hearty
Osteomalacia is a medical condition that results in the weakening of bones. This article provides some information about this ... Osteomalacia. Osteomalacia is a medical condition that results in the weakening of bones. This article provides some ... Osteomalacia refers to a disease wherein the bones become soft due to the lack of Vitamin D in ones body. The terms Osteo ... Though osteomalacia is a bone disorder, it is different from osteoporosis that is also related to weak bones and leads to bone ...
Osteomalacia | Profiles RNS
"Osteomalacia" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Osteomalacia" by people in this website by year, and whether " ... Niemeier T, Leddy L, Bolster M, Chapin R. Insufficiency fracture associated with oncogenic osteomalacia. J Clin Rheumatol. 2013 ... Below are the most recent publications written about "Osteomalacia" by people in Profiles. ...
Osteomalacia Archives - Doctors Gang
Osteomalacia presenting as pain syndromes of uncertain etiology.<...
Osteomalacia presenting as pain syndromes of uncertain etiology. South Dakota medicine : the journal of the South Dakota State ... Osteomalacia presenting as pain syndromes of uncertain etiology. In: South Dakota medicine : the journal of the South Dakota ... Lal, Y., Nair, P., Lovrien, F., & Freeman, J. W. (2009). Osteomalacia presenting as pain syndromes of uncertain etiology. South ... Osteomalacia presenting as pain syndromes of uncertain etiology. / Lal, Yasir; Nair, Preetha; Lovrien, Fred et al. ...
Frontiers | The burden of vitamin D deficiency in household members of children presenting with symptomatic vitamin D deficiency
Biochemical osteomalacia was present in 72% of the maternal and 79% of the sibling cohorts. Mothers of infants had ... Biochemical osteomalacia was present in 72% of the maternal and 79% of the sibling cohorts. Mothers of infants had ... and biochemical osteomalacia [vitamin D deficiency and elevated alkaline phosphatase (ALP) and/or parathormone (PTH)] as per ... and biochemical osteomalacia [vitamin D deficiency and elevated alkaline phosphatase (ALP) and/or parathormone (PTH)] as per ...
Tumor-Induced Osteomalacia (TIO) Information - Ultragenyx
Tumor-Induced Osteomalacia (TIO). Tumor-Induced Osteomalacia (TIO). /*! elementor - v3.6.4 - 13-04-2022 */ .elementor-widget- ... Tumor-induced Osteomalacia (TIO) "Its okay to say, Im having a really hard time, but within that to say, Are there little ... Tumor-induced Osteomalacia (TIO) "At 50 years old, I was a healthy, strong workaholic until everything changed." ... If you are aware of any tumor-induced osteomalacia (TIO) advocacy groups, please contact [email protected]. ...
Instructions for Classifying Multiple Causes of Death, 2019 - Section II
FDA Approves Crysvita for Victims of Tumor-Induced Osteomalacia
and Kyowa Kirin Co., Ltd., was approved by the FDA for treating X-linked hypophosphatemia and tumor-induced osteomalacia. ... FDA Approves Crysvita for Victims of Tumor-Induced Osteomalacia. by Judy Ya-Hsuan Lin ... Excessive FGF23 diseases include X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia (TIO). XLH affects ... in Japan approved it for the treatment of FGF23-related hypophosphatemic rickets and osteomalacia. Europe received conditional ...
Stem Cell Treatment Osteomalacia in Delhi, India | Osteomalacia Therapy
The correct treatment and cure is provided by Viezec in Stem Cell Treatment Osteomalacia in Delhi. We offer promising ... stem cell treatment for Osteomalacia, stem cell therapy for Osteomalacia, stem cell Osteomalacia Treatment, Osteomalacia stem ... Bill Favela underwent stem cell treatment for osteomalacia. I am a chronic patient of osteomalacia. Since I have osteomalacia, ... What is Osteomalacia?. Osteomalacia is the milder type of bone disorder, often related to softer bone tissue, typically as a ...
Tumor-induced Osteomalacia Resources | CRYSVITA® (burosumab-twza) for TIO
Help patients understand tumor-induced osteomalacia (TIO) and connect with communities of support. ... osteomalacia. A softening and weakening of the bones in adults caused by deficiencies in vitamin D, calcium, or phosphate. In ... Osteomalacia and bone histomorphometry. Mineralization of the bone matrix (osteoid) is a critical step during bone formation. ... Osteomalacia is characterized by the following histomorphometric features: *Increased osteoid volume/bone volume ...
Hypocalcemia due to spontaneous infarction of parathyroid adenoma and osteomalacia in a patient with primary...
Cadmium Toxicity: Clinical Assessment - Exposure History and Physical Examination | Environmental Medicine | ATSDR
osteomalacia and tension headaches have similar cause Archives - Holistic Health & Living
The Assistance Fund Opens New Program for Tumor-Induced Osteomalacia - The Assistance Fund
RELEASE Financial Assistance From The Assistance Fund Now Available for Eligible People Living With Tumor-Induced Osteomalacia ... Tumor-induced osteomalacia is a rare disease that occurs when small tumors grow in the skin, muscles, or bones. TIO, sometimes ... "People living with tumor-induced osteomalacia not only face the challenge of an often debilitating diagnosis, they also must ... "The Assistance Fund is excited to announce the launch of our new Tumor-Induced Osteomalacia Financial Assistance Program," said ...
How Much Vitamin D Is Too Much Vitamin D? - NDTV Food
7 Amazing Benefits of Vitamin D | Organic Facts
... and osteomalacia, controlling phosphate and calcium levels, and preventing bone fractures PAD and cancer. ... Osteomalacia is most often found in adults. The main symptoms of osteomalacia are an increase in bone fractures, a waddling ... Osteomalacia is treated with an oral dose of vitamin D and direct exposure to the sun. When there isnt an option for natural ... Osteomalacia means soft bones, and the disease of the same name refers to there being an issue with bones being weak or brittle ...
OsteoporosisBonesOncogenicHypophosphatemic rickets and osteomalaciaVitaminRickets in childrenAdultsDiagnosisTerm osteomalaciaHypophosphatemiaRenalMineralizationDisorderAdultDiseaseSymptomsSymptomaticTumorInsufficiencyNutritionalBiochemicalDescriptorSkeletalCollagenClinicalChildrenChronicIndiaBone lossDiagnoseDeficiencyPain
Osteoporosis6
- More importantly, osteomalacia can look like weakening of the bones from osteoporosis on bone density testing. (medlineplus.gov)
- Though osteomalacia is a bone disorder, it is different from osteoporosis that is also related to weak bones and leads to bone fractures. (healthhearty.com)
- However, it is an imperative component that Stem Cell Treatment Osteomalacia and Osteoporosis or Osteopenia are usually very different from each other as Osteoporosis or Osteopenia is the diminishing or loss of formerly constructed bones, but Osteomalacia is the shortcoming in the bone-developing process itself. (viezec.com)
- soft or brittle bones (osteoporosis, osteomalacia). (everydayhealth.com)
- The conditions most commonly associated with ow levels of Vitamin D are osteoporosis, and osteomalacia. (ener-life.com)
- Osteoporosis and osteomalacia both target the skeletal system. (ener-life.com)
Bones15
- Osteomalacia is softening of the bones. (medlineplus.gov)
- Rickets only develops in children whose bones are still growing, whereas osteomalacia can develop in people of all ages. (medicalnewstoday.com)
- Rickets can cause deformed bones in children and limit their growth, while deformities usually only occur in severe cases of osteomalacia. (medicalnewstoday.com)
- The most common symptoms of osteomalacia, such as sore bones and muscles, are vague enough that it can sometimes take 2-3 years to diagnose the condition. (medicalnewstoday.com)
- Osteomalacia is a medical condition that results in the weakening of bones. (healthhearty.com)
- Osteomalacia refers to a disease wherein the bones become soft due to the lack of Vitamin D in one's body. (healthhearty.com)
- Tumor-induced osteomalacia is a rare disease that occurs when small tumors grow in the skin, muscles, or bones. (tafcares.org)
- TIO, sometimes referred to as oncogenic osteomalacia, results in weakened bones and kidneys, as well as elevated levels of urine. (tafcares.org)
- Osteomalacia means soft bones, and the disease of the same name refers to there being an issue with bones being weak or brittle. (organicfacts.net)
- Osteomalacia causes soft and deformed bones, commonly due to insufficient phosphorus or vitamin D in the diet. (merckvetmanual.com)
- Because it interferes with vitamin D metabolism, phenytoin can cause weakening of the bones (osteomalacia). (medicinenet.com)
- Osteomalacia, on the other hand, is a softening of the bones leading to muscle weakness, and dull and aching pain in the back, pelvis, hips and legs. (ener-life.com)
- Osteomalacia, a disease affecting adults by softening the bones. (lvdtraining.com)
- In severe cases, vitamin D deficiency can also lead to osteomalacia, a condition characterized by weak and soft bones. (ziggiesocial.com)
- Because vitamin D's active hormone, calcitriol, is particularly beneficial to bone health due to its role in aiding calcium and phosphorous absorption, a deficiency can lead to thin, brittle, misshapen bones, or the bone disease, osteomalacia (known as rickets in children). (antiaging-nutrition.com)
Oncogenic3
Hypophosphatemic rickets and osteomalacia3
- Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. (duke.edu)
- In order to determine whether a defect in vitamin D metabolism might play a role in the pathogenesis of X-linked hypophosphatemic rickets and osteomalacia (XLH), we compared the serum 1,25-dihydroxyvitamin D [1,25(OH)2D] level in 52 normal subjects and 37 patients with XLH. (duke.edu)
- The Ministry of Health, Labor and Welfare (MHLW) in Japan approved it for the treatment of FGF23-related hypophosphatemic rickets and osteomalacia. (geneonline.com)
Vitamin13
- Eating a diet rich in vitamin D and calcium and getting sufficient exposure to sunlight can help prevent osteomalacia due to vitamin D deficiency. (medlineplus.gov)
- To prevent rickets or osteomalacia in children, experts recommend daily doses of 600 IU vitamin D and dietary calcium in pregnant people and 400 IU daily in infants from birth. (medicalnewstoday.com)
- Vitamin D deficiency can result in symptomatic osteomalacia which may cause bone pain and muscle weakness. (elsevier.com)
- Investigate the prevalence of vitamin D deficiency and biochemical osteomalacia in the mothers and siblings of children presenting with symptomatic vitamin D deficiency. (frontiersin.org)
- 30nmol/L] and biochemical osteomalacia [vitamin D deficiency and elevated alkaline phosphatase (ALP) and/or parathormone (PTH)] as per clinical guidelines. (frontiersin.org)
- Osteomalacia is the milder type of bone disorder, often related to softer bone tissue, typically as a result of vitamin D deficiency. (viezec.com)
- The health benefits of vitamin D, also known as calciferol, include curing rickets, the treatment of osteomalacia, protection against peripheral arterial disease (PAD), slowing the progression of cancer, preventing bone fractures, and treating rachitic rosary. (organicfacts.net)
- The diseases caused by vitamin D deficiency are osteomalacia and rickets. (organicfacts.net)
- Dr. Holick describes the link between vitamin D and osteomalacia. (empowher.com)
- Osteomalacia And Vitamin D, What Is The Connection? (empowher.com)
- Severe vitamin D deficiency causes rickets in children and osteomalacia in adults. (oregonstate.edu)
- A lack of vitamin D can lead to bone deformities such as rickets in children, and bone pain caused by a condition called osteomalacia in adults. (revolverdeblake.com)
- In its proposed local coverage determination (LCD), the Medicare carrier indicates that it would cover Vitamin D testing only for patients with chronic kidney disease, osteomalacia, hypercalcemia, and rickets. (darkdaily.com)
Rickets in children1
- However, its deficiency can cause rickets in children and osteomalacia in adults. (organicfacts.net)
Adults3
- Reduced bone mineralization (osteomalacia) affects adults and children and children additionally develop the growth plate disorder rickets ( 11 ). (frontiersin.org)
- Osteomalacia is most often found in adults. (organicfacts.net)
- 11(4) children and osteomalacia in adults. (who.int)
Diagnosis4
- FGF-23 levels were significantly increased, and total body magnetic resonance imaging (MRI) revealed a tumor mass located at the distal tibia leading to the diagnosis of tumor-induced osteomalacia (TIO). (hindawi.com)
- Biochemical tests confirmed the initial clinical diagnosis of osteomalacia. (who.int)
- People living with tumor-induced osteomalacia not only face the challenge of an often debilitating diagnosis, they also must grapple with financial barriers to critical treatment. (tafcares.org)
- Combined with unbearable bone pain, spontaneous fractures, changes in laboratory markers and the result of ECT and other radiographic findings, the diagnosis of Fanconi's syndrome with osteomalacia was established. (qxmd.com)
Term osteomalacia2
- These images are a random sampling from a Bing search on the term "Osteomalacia. (fpnotebook.com)
- In the case of children, it is commonly referred to as rickets and the term osteomalacia is used only in the case of the adult form of the disease. (healthhearty.com)
Hypophosphatemia2
- Tumor-induced osteomalacia (TIO) is a rare, acquired paraneoplastic disorder characterized by a renal phosphate leak leading to hypophosphatemia and deranged bone turnover. (hindawi.com)
- Excessive FGF23 diseases include X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia (TIO). (geneonline.com)
Renal1
- Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition. (qxmd.com)
Mineralization1
- One of the most important aspects of osteomalacia treatment is to make sure that a person gets the levels of nutrients they need to support the bone mineralization process. (medicalnewstoday.com)
Disorder1
- Contact your health care provider if you have symptoms of osteomalacia, or if you think that you may be at risk for this disorder. (medlineplus.gov)
Adult2
- Osteomalacia associated with adult Fanconi's syndrome: clinical and diagnostic features. (qxmd.com)
- adult osteomalacia (M83. (icdcodesinfo.com)
Disease2
- Tumor-induced osteomalacia (TIO) is a rare disease caused by tumors. (ultrarareadvocacy.com)
- In horses, osteomalacia is sometimes known as bran disease, miller's disease , and " big head . (merckvetmanual.com)
Symptoms1
- The main symptoms of osteomalacia are an increase in bone fractures, a waddling walk, and muscle weakness. (organicfacts.net)
Symptomatic2
- Two patients with symptomatic osteomalacia after gastric bypass surgery are discussed. (elsevier.com)
- FHH3 patients have heterozygous AP2S1 missense Arg15 mutations (p.Arg15Cys, p.Arg15His or p.Arg15Leu) with hypercalcaemia, which may be marked and symptomatic, and occasional hypophosphataemia and osteomalacia. (birmingham.ac.uk)
Tumor6
- Tumor-induced Osteomalacia: Pipeline Rev. (rootsanalysis.com)
- If you are aware of any tumor-induced osteomalacia (TIO) advocacy groups, please contact [email protected] . (ultrarareadvocacy.com)
- ORLANDO, Fla., October 14, 2020 -The Assistance Fund, an independent charitable patient assistance organization that helps patients and families facing high medical out-of-pocket costs, today announced the launch of a new financial assistance program for people living with tumor-induced osteomalacia (TIO). (tafcares.org)
- The Assistance Fund is excited to announce the launch of our new Tumor-Induced Osteomalacia Financial Assistance Program," said Mark P. McGreevy, President and CEO of The Assistance Fund. (tafcares.org)
- Tumor-induced osteomalacia: rhinosinusal hemangiopericytoma]. (bvsalud.org)
- Osteomalacia inducida por tumor: hemangiopericitoma rinosinusal. (bvsalud.org)
Insufficiency1
- Supplement D insufficiency is the most notable purpose behind osteomalacia around the globe. (viezec.com)
Nutritional1
- American countries is characterized by the increase (kwashiokor, nutritional marasmus) or specific lacks in the prevalence of overweight and obesity and a (hipovitaminosis A, scurvy, beriberi, rickets, reduction in the prevalence of under-weight, a deficit osteomalacia, pellagra, anemia), constituting in stature still persisting in high proportions3-7. (bvsalud.org)
Biochemical1
- Biochemical osteomalacia was present in 72% of the maternal and 79% of the sibling cohorts. (frontiersin.org)
Descriptor1
- Osteomalacia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
Skeletal1
- Hypophosphatemic osteomalacia induced by low-dose adefovir therapy: focus on manifestations in the skeletal system and literature review. (qxmd.com)
Collagen1
- When people have osteomalacia, the shell does not form fully, leaving the collagen soft and vulnerable. (medicalnewstoday.com)
Clinical1
- It is seen that this bone resorption is more in Osteomalacia, as a result of some clinical issues, for example, hyperthyroidism or hypocalcemia and so on. (viezec.com)
Children1
- In children, osteomalacia can occur simultaneously with rickets. (crysvita.com)
Chronic1
- This case indicates that Fanconi's syndrome with osteomalacia can be acquired by a chronic hepatitis B patient taking ADV at a conventional dosage of 10 mg/day. (qxmd.com)
India1
- People are searching for Stem Cell Treatment for Osteomalacia in Delhi, India, but can't seem to find the best Osteomalacia Treatment hospitals at an affordable price. (viezec.com)
Bone loss1
- With osteomalacia, the problem is not bone loss. (medicalnewstoday.com)
Diagnose1
- However, once a doctor suspects osteomalacia, several different tests can help them diagnose it. (medicalnewstoday.com)
Deficiency1
- As osteomalacia progresses, you may make bone torment and muscle deficiency. (viezec.com)
Pain3
- Osteomalacia presenting as pain syndromes of uncertain etiology. (elsevier.com)
- Dive into the research topics of 'Osteomalacia presenting as pain syndromes of uncertain etiology. (elsevier.com)
- We report a case of low-dose ADV-induced hypophosphatemic osteomalacia that initially presented as diffuse musculoskeletal pain. (qxmd.com)