The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.
A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.
A low-osmolar, ionic contrast medium used in various radiographic procedures.
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
Drugs that bind to and block the activation of ADRENERGIC ALPHA-2 RECEPTORS.
An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Solutions that have a greater osmotic pressure than a reference solution such as blood, plasma, or interstitial fluid.
Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.
Drugs that selectively bind to and activate alpha adrenergic receptors.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Substances used to allow enhanced visualization of tissues.
The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
A ubiquitous sodium salt that is commonly used to season food.
Sodium excretion by URINATION.
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

Increased insensible water loss in newborn infants nursed under radiant heaters. (1/9547)

Urine osmolality was studied in 38 babies nursed in conventional incubators or cots and 18 nursed under an overhead radiant heat shield. Among 50 babies receiving a similar fluid intake in the first 48 hours of life mean urinary osmolality was significantly higher in the radiant heater group. In babies weighing less than 1500 g a trend towards higher urinary osmolalities was recorded in those nursed under radiant heaters even though they had received amost double the fluid intake of the incubator group. Severe hypernatraemia occurred in four of the five babies weighing less than 1000 g who were nursed under radiant heaters but in none of the seven babies of similar birth weight nursed in incubators. These findings are consistent with previous observations of an increase in insensible water loss in babies nursed under radiant heaters and emphasise the importance of providing enough extra water for these infants and the need for close monitoring of their fluid balance. The latter may be done at the bedside by measuring urinary specific gravity with a hand refractometer.  (+info)

Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. (2/9547)

It has been controversial whether high water permeability in the thin descending limb of Henle (TDLH) is required for formation of a concentrated urine by the kidney. Freeze-fracture electron microscopy (FFEM) of rat TDLH has shown an exceptionally high density of intramembrane particles (IMPs), which were proposed to consist of tetramers of aquaporin-1 (AQP1) water channels. In this study, transepithelial osmotic water permeability (Pf) was measured in isolated perfused segments (0.5-1 mm) of TDLH in wild-type (+/+), AQP1 heterozygous (+/-), and AQP1 null (-/-) mice. Pf was measured at 37 degrees C using a 100 mM bath-to-lumen osmotic gradient of raffinose, and fluorescein isothiocyanate (FITC)-dextran as the luminal volume marker. Pf was (in cm/s): 0.26 +/- 0.02 ([+/+]; SE, n = 9 tubules), 0.21 +/- 0.01 ([+/-]; n = 12), and 0.031 +/- 0.007 ([-/-]; n = 6) (P < 0.02, [+/+] vs. [+/-]; P < 0.0001, [+/+] vs. [-/-]). FFEM of kidney medulla showed remarkably fewer IMPs in TDLH from (-/-) vs. (+/+) and (+/-) mice. IMP densities were (in microm-2, SD, 5-12 micrographs): 5,880 +/- 238 (+/+); 5,780 +/- 450 (+/-); and 877 +/- 420 (-/-). IMP size distribution analysis revealed mean IMP diameters of 8.4 nm ([+/+] and [+/-]) and 5.2 nm ([-/-]). These results demonstrate that AQP1 is the principal water channel in TDLH and support the view that osmotic equilibration along TDLH by water transport plays a key role in the renal countercurrent concentrating mechanism. The similar Pf and AQP1 expression in TDLH of (+/+) and (+/-) mice was an unexpected finding that probably accounts for the unimpaired urinary concentrating ability in (+/-) mice.  (+info)

Relaxin is a potent renal vasodilator in conscious rats. (3/9547)

The kidneys and other nonreproductive organs vasodilate during early gestation; however, the "pregnancy hormones" responsible for the profound vasodilation of the renal circulation during pregnancy are unknown. We hypothesized that the ovarian hormone relaxin (RLX) contributes. Therefore, we tested whether the administration of RLX elicits renal vasodilation and hyperfiltration in conscious adult, intact female rats. After several days of treatment with either purified porcine RLX or recombinant human RLX 2 (rhRLX), effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) increased by 20%-40%. Comparable renal vasodilation and hyperfiltration was also observed in ovariectomized rats, suggesting that estrogen and progesterone are unnecessary for the renal response to rhRLX. The nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyl ester completely abrogated the increase in ERPF and GFR elicited by chronic administration of purified porcine RLX. In contrast, the renal vasoconstrictory response to angiotensin II was attenuated by the RLX treatment. Short-term infusion of purified porcine RLX to conscious rats over several hours failed to increase ERPF and GFR. Plasma osmolality was consistently reduced by the chronic administration of both RLX preparations. In conclusion, the renal and osmoregulatory effects of chronic RLX administration to conscious rats resemble the physiological changes of pregnancy in several respects: (a) marked increases in ERPF and GFR with a mediatory role for nitric oxide; (b) attenuation of the renal circulatory response to angiotensin II; and (c) reduction in plasma osmolality.  (+info)

The sodium concentration of enteral diets does not influence absorption of nutrients but induces intestinal secretion of water in miniature pigs. (4/9547)

Contradictory opinions exist as to whether the sodium concentration of enteral diets influences absorption of macronutrients and transepithelial movement of sodium and water. Therefore, we investigated the effects of various sodium concentrations of enteral diets on absorption of macronutrients and on net fluxes of sodium and water. In unanesthetized miniature pigs, a 150-cm jejunal segment was perfused with an oligopeptide (Peptisorb), an oligomeric and a polymeric diet. The polymeric diet was supplemented with pancreatic enzymes. The sodium concentrations varied between 30 and 150 mmol/L. The energy density was 3.4 MJ/L. The sodium concentration of the diets did not influence absorption of macronutrients and of total energy. However, increasing sodium concentrations of the diets were associated with increasing osmolality of the solutions, resulting in a linear increase in net secretion of water and flow rate of chyme. With all diets and sodium concentrations net secretion of sodium occurred. The sodium secretion was independent of the initial sodium concentration of the diets. It was linearly correlated with net flux of water and was largest in miniature pigs infused with the oligomeric diet. The sodium concentration of the jejunal effluent did not correspond to the initial sodium concentration of the diets. The present results indicate that enteral feeding of diets with high energy density inevitably increases net secretion of water and sodium as sodium concentration increases. Therefore, the sodium concentration of diets should be as low as possible to meet only the minimal daily requirement of sodium. Low sodium concentrations of diets have no negative effects on absorption of macronutrients.  (+info)

Treating the syndrome of inappropriate ADH secretion with isotonic saline. (5/9547)

It has been widely accepted that there is little use for saline treatment in the syndrome of inappropriate secretion of ADH (SIADH). However, having observed that most SIADH patients increased their plasma sodium (PNa) after 2 l isotonic saline over 24 h, we investigated whether urine osmolality or the sum of urinary sodium and potassium (UNa + K) predicted this response, in 17 consecutive patients with chronic SIADH. The initial measure of urinary sodium plus potassium (UNa + K t0) was weakly correlated to the change in PNa (DPNa) after infusion (r = -0.51; p < 0.05), while initial urine osmolality (UOSM t0) was a much better predictor (y = -0.024x + 12.90; r = -0.81; p < 0.001). The lack of predictive value for UNa + K t0 was probably because urine electrolyte concentrations were not maximal for the corresponding initial UOSM. This reflects differences in salt intake between the patients. The theoretical maximal value for UNa + K t0 (th max UNa + K t0) for a given USOM t0, was as good a predictor as UOSM t0 (th max UNa + K vs. DPNa: r = -0.81; p < 0.001). A theoretical model describing the effect of 2 l isotonic saline infusion on DPNa as a function of UNa + K, produced values comparable to those observed in our patients. Only 6/17 patients, those with UOSM > 530 mOsm/kg, had their hyponatraemia aggravated by 2 l isotonic saline. Many SIADH patients have lower UOSM; in most such patients, 2 l of isotonic saline will improve PNa.  (+info)

MENT, a heterochromatin protein that mediates higher order chromatin folding, is a new serpin family member. (6/9547)

Terminal cell differentiation is correlated with the extensive sequestering of previously active genes into compact transcriptionally inert heterochromatin. In vertebrate blood cells, these changes can be traced to the accumulation of a developmentally regulated heterochromatin protein, MENT. Cryoelectron microscopy of chicken granulocyte chromatin, which is highly enriched with MENT, reveals exceptionally compact polynucleosomes, which maintain a level of higher order folding above that imposed by linker histones. The amino acid sequence of MENT reveals a close structural relationship with serpins, a large family of proteins known for their ability to undergo dramatic conformational transitions. Conservation of the "hinge region" consensus in MENT indicates that this ability is retained by the protein. MENT is distinguished from the other serpins by being a basic protein, containing several positively charged surface clusters, which are likely to be involved in ionic interactions with DNA. One of the positively charged domains bears a significant similarity to the chromatin binding region of nuclear lamina proteins and with the A.T-rich DNA-binding motif, which may account for the targeting of MENT to peripheral heterochromatin. MENT ectopically expressed in a mammalian cell line is transported into nuclei and is associated with intranuclear foci of condensed chromatin.  (+info)

A method for analyzing enzyme kinetics with substrate activation and inhibition and its application to the alpha-chymotrypsin-catalyzed hydrolysis of phenyl acetates. (7/9547)

A general kinetic method was developed to analyze enzyme-catalyzed systems complicated by the presence of activation or inhibition by substrate. The method was applied to the alpha-chymotrypsin [EC 3.4.21.1]-catalyzed hydrolysis of p-chlorophenyl and p-methoxyphenyl acetates. Deacylation rate constants which were not complicated by substrate activation were obtained. The analysis shows that the abnormal substituent dependence of kcat in the steady state hydrolysis is due not to substrate activation but to inappropriateness of the two-step mechanism or the existence of more than one acetyl-enzyme intermediate.  (+info)

H5 Histone and DNA-relaxing enzyme of chicken erythrocytes. Interaction with superhelical DNA. (8/9547)

The interaction of closed circular duplex DNA with the lysine-rich H5 histone fraction of avian erythrocytes has been studied. H5, like H1 histone, interacts preferentially with superhelical DNA. The extent of interaction increases with increasing negative or positive superhelicity. Salt-extracted lysine-rich histones show the same specificity for interaction with superhelices as do acid-extracted preparations. Chicken erythrocyte nuclei contain DNA-relaxing enzyme. This enzyme is extracted from the nuclei at lower salt concentrations than those required to extract H1 and H5 histones and is, therefore, probably a function of a protein distinct from H1 and H5 histones.  (+info)

inproceedings{2017HistidineTB, title={Histidine Tagging Both Allows Convenient Single-step Purification of Bovine Rhodopsin and Exerts Ionic Strength-dependent Effects on Its Photochemistry*}, author={}, year={2017 ...
A packed-bed chromatographic model developed in this study includes adsorption isotherms considering steric mass action (SMA) as well as non-linearity in liquid/solid phases, adsorption kinetics and mass transport. For solving the nonlinear and nonequilibrium adsorption model described by a partial differential algebraic equation (PDAE) system, a fast and accurate numerical method (i.e., conservation element/solution element (CE/SE) method), is proposed. Sensitivity and elasticity of the model parameters (e.g., steric/shape factors, adsorption heat coefficient, effective protein charge, equilibrium constant, mass transfer coefficient, axial dispersion coefficient and bed voidage) are analyzed for a BSA-salt system in a low protein concentration range. Within a low concentration range of bovine serum albumin (BSA) where linear adsorption isotherms are shown, the adsorption heat coefficient, shape and steric factors have little effect on adsorption isotherms and the retention time. However, the ...
Low-ionic-strength saline (LISS) techniques permit a safe and substantial reduction in incubation time and have therefore become the method of choice for antibody detection and compatibility testing in many transfusion laboratories. Consequently, the supply of reagent red cells (RBCs) in a low-ionic-strength preservative solution would remove the daily need for laboratories to wash and resuspend cells in LISS before use. However, the storage of fresh RBCs at low ionic strength in the presence of aminoglycoside antibiotics can cause a rapid loss of certain antigens, possibly as a result of the release of proteolytic enzymes from contaminating white cells. This article describes a low-ionic-strength solution that achieves preservation of antigens on liquid nitrogen-frozen-thawed RBCs for 21 days storage at 4°C. ...
The goal was to characterize a hydrophobic cytokine with respect to oxidation and aggregation, as well as its adsorption to the container at different pH and ionic strength conditions. The tendency of the cytokine to adsorb on surfaces and its low solubility at physiological pH were the main challenges during the development of HSA-free formulations for the cytokine. When the formulation pH exceeded 5.5 precipitation led to significantly higher turbidity. This turbidity increase and elevated aggregation as determined by HP-SEC and DLS was more pronounced at higher glycine and NaCl concentrations. With rising pH protein adsorption was more distinct compared to pH 3.0. However, protein adsorption could be minimized by polysorbate 20 or the use of glass type I(+). FTIR revealed a reduced thermal stability at higher pH values indicated by a declining denaturation temperature. Five liquid formulations in the pH range 3.5-4.5 and five lyophilized formulations at pH 4.0-5.0 were stored for 6 months and ...
Dive into the research topics of Effect of ionic strength on the conformation of myosin subfragment 1-nucleotide complexes. Together they form a unique fingerprint. ...
Osmotic Challenges Osmoconformers, consisting only of some marine animals, are isoosmotic with their surroundings and do not regulate their osmolarity Osmoregulators expend energy to control water uptake and loss in a hyperosmotic or hypoosmotic environment Most animals are stenohaline; they cannot tolerate substantial changes in external osmolarity Euryhaline animals can survive large fluctuations in external osmolarity
Osmoreceptors are sensory receptor primarily found in hypothalamus of most homoeothermic organisms that detects changes in osmotic pressure. T
WHEN I PENNED The Green Consumer in 1990, I helped advance the notion that we could solve our planets environmental problems by making good purchasing choices. That we could, in other words, shop our way to environmental health. By choosing carefully, you can have a positive impact on the environment without significantly compromising your way of life, I wrote. Thats what being a Green Consumer is all about.. I fought the good fight. Twenty years later, Im thinking of waving the white flag. Green consumerism, it seems, was one of those well-intended passing fancies, testament to Americans never-ending quest for simple, quick, and efficient solutions to complex problems.. Today, its become clear that good purchasing choices are relatively few and far between, in terms of products whose environmental benefits are both obvious and significant. True, there are green cleaners, organic socks, energy-efficient lightbulbs, and fuel-efficient cars, but such products are scarce compared with the ...
TY - JOUR. T1 - Adsorption of polysterene sulfonate on polymethylene single cristals at high ionic strength. AU - Papenhuijzen, J.. AU - Fleer, G.J.. AU - Bijsterbosch, B.H.. PY - 1985. Y1 - 1985. M3 - Article. VL - 104. SP - 530. EP - 539. JO - Journal of Colloid and Interface Science. JF - Journal of Colloid and Interface Science. SN - 0021-9797. ER - ...
If the solute concentration in the blood is too high, osmoreceptors in the hypothalamus sense this and signal the pituitary gland to produce a hormone called ADH (anti-diuretic hormone). ADH causes special pores called aquaporins in the collecting duct to open, allowing water to be reabsorbed back into the blood, thus making the blood more dilute. If the solute concentration in the blood is too low, osmoreceptors in the hypothalamus sense this and signal the pituitary gland to reduce its production of ADH. This causes the aquaporins in the collecting duct to close, keeping the excess water in the filtrate, which excreted as dilute urine. This is called osmoregulation ...
Whether or not this statement is correct will depend on how dark the urine is, because the depth of color in urine will vary inversely with the urinary volume. Although the volume varies greatly among individuals, in our student laboratory (see above, under Other Data Since 8 × 8) the mean value was 1,520 ml/24 h (Table 3), with a mean urine osmolality of 590 mosmol/kgH2O. Both values are those generally cited as being normal, namely, 1,500 ml/24 h and 600 mosmol/kgH2O, respectively (73, 92). At a urine osmolality ∼600 mosmol/kgH2O, the concentration of solutes in the urine is such that the urine has a moderately yellow color, which might be interpreted as dark, especially when contrasted against pale yellow or clear, which is specified in most of the lay literature (26). Yet, at the above-cited normal urinary volume and osmolality, the plasma osmolality will be well within the normal range and nowhere near the values of 300 mosmol/kgH2O and higher, which are seen in meaningful ...
Plasma osmolality measures the bodys electrolyte-water balance. There are several methods for arriving at this quantity through measurement or calculation. Osmolality and osmolarity are measures that are technically different, but functionally the same for normal use. Whereas osmolality (with an l) is defined as the number of osmoles (Osm) of solute per kilogram of solvent (osmol/kg or Osm/kg), osmolarity (with an r) is defined as the number of osmoles of solute per liter (L) of solution (osmol/L or Osm/L). As such, larger numbers indicate a greater concentration of solutes in the plasma.. ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Our results reveal that hyperosmolarity is associated with increased hospital mortality of patients who are critically ill, presenting as a U-shaped association. However, this pattern was not observed for patients with respiratory admission disease, and only extreme hyperosmolarity was related to increased risk of death in this subgroup. In addition, vasopressin is strongly associated with a higher mortality rate in all six subgroups. To the best of our knowledge, this is the largest study using subgroup analysis to establish a link between osmolarity imbalance and mortality in patients in mixed ICU.. Water balance inside the body is of vital importance for patients who are critically ill , and serum osmolarity plays an important role in extracellular and intracellular water distribution. Perturbation of osmolarity is common in patients admitted to ICU, which is related to intracellular dehydration or oedema, potentially leading to adverse outcomes.17 Holtfreter et al recently examined the ...
Osmolality determination- Osmolality of blood increases with dehydration and decreases with overhydration. Normal range: 285-295 mOsm/kg
Osmolality is a test that measures the concentration of all chemical particles found in the fluid part of blood. Osmolality can also be measured with a urine test.
Osmolarity is a measurement of the number of particles in a solute, typically expressed in osmoles. Researchers need to know this...
Looking for online definition of blood osmolality in the Medical Dictionary? blood osmolality explanation free. What is blood osmolality? Meaning of blood osmolality medical term. What does blood osmolality mean?
Authors: Lisovskaya, I.L. , Shurkhina, E.S. , Yakovenko, E.E. , Tsvetaeva, N.V. , Kolodei, S.V. , Shcherbinina, S.P. , Ataullakhanov, F.I. Article Type: Research Article Abstract: We have previously proposed the osmofiltration method based on a modified Hanss hemorheometer to analyze distributions of erythrocytes in their ability to pass through membrane filters with 3 \mu m pores. Upon decrease in medium osmolality (u ) the erythrocyte volume increases. When cell volume becomes V=V_{\mathrm{cr}} at u=u_{\mathrm{cr}} , such cell loses its ability to pass through a 3 \mu m pore. The flow rate of erythrocyte suspension containing cells with different u_{\mathrm{cr}} through a filter gradually decreases with decreasing medium osmolality. This rate becomes zero at some u=\Omega , …when the number of non‐filterable cells in the applied sample approaches the number of pores in filter. Experimental determination of the dependencies of the filtration rate on medium osmolality for various hematocrit ...
The physical properties of weak polyelectrolytes may be tailored via hydrophobic modification to exhibit useful properties under appropriate pH and ionic strength conditions as a consequence of the often inherently competing effects of electrostatics and hydrophobicity. Pulsed-gradient spin-echo NMR (PGSE-NMR), electron paramagnetic resonance (EPR), small-angle neutron scattering (SANS) surface tension, fluorescence, and pH titration have been used to examine the solution conformation and aggregation behavior of a series of hydrophobically modified hyperbranched poly(ethylene imine) (PEI) polymers in aqueous solution, and their interaction with sodium dodecylsulfate (SDS). PGSE-NMR gave a particularly insightful picture of the apparent molecular weight distribution. The presence of the hydrophobes led to a lower effective charge on the polymer at any given pH, compared to the (parent) nonmodified samples. Analysis of the SANS data showed that the propensity to form highly elliptical or rod-like ...
UOSMU : Osmolality is an index of the solute concentration. Urine osmolality is a measure of the concentration of osmotically active particles, principally sodium, chloride, potassium, and urea; glucose can contribute significantly to the osmolality when present in substantial amounts in urine. Urinary osmolality corresponds to urine specific gravity in nondisease states.   The ability of the kidney to maintain both tonicity and water balance of the extracellular fluid can be evaluated by measuring the osmolality of the urine either routinely or under artificial conditions. More information concerning the state of renal water handling or abnormalities of urine dilution or concentration can be obtained if urinary osmolality is compared to serum osmolality and if urine electrolyte studies are performed. Normally, the ratio of urine osmolality to serum osmolality is 1.0 to 3.0, reflecting a wide range of urine osmolality.
Intracellular measurements of the resting potential were made in fibers of the frog sartorius muscle in solutions of varying salt composition and concentration to determine the effects of low ionic strength extracellular solutions on the resting potential. Changes in the glass microelectrode tip potential in low ionic strength solutions were minimized by adding ThCl4 to the extracellular solution. These experimental conditions allowed measurement of the relationship of the resting potential to the concentration of the salt in the extracellular solution by replacing it with the nonionic substance, sucrose. Substitution of sucrose for the extracellular NaCl produced a stable depolarization which was logarithmically related to the NaCl concentration. Substitution of sucrose for choline Cl, instead of NaCl, produced the same degree of depolarization. When Na salts of anions less permeable than chloride (Br, I, NO3) were used, the resting potentials in 116 mM solutions were close to those with ...
The production of materials such as microfibrillated cellulose and cellulose nanocrystals is gathering significant research interest by combining mechanical strength and toughness with a low density, biodegradability and renewability. However, one of the challenges with production on an industrial scale is to obtain an energy-efficient solid liquid separation which is difficult because of the high specific filtration resistance of these materials. This study investigates electroassisted filtration as a method to facilitate the dewatering of cellulosic materials and the influence of ionic strength on the electrofiltration behavior. Electroassisted filtration is found to improve the dewatering rate of the studied cellulosic material, and the potential improvement compared to pressure filtration increased with the specific surface area of the solid material. Increasing the ionic strength of the system increased the power demand of the electroassisted filtration, and the major potential for industrial
Plasma osmolality measures the bodys electrolyte-water balance. There are several methods for arriving at this quantity through measurement or calculation. Osmolality and osmolarity are measures that are technically different, but functionally the same for normal use. Whereas osmolality (with an ℓ) is a measure of the osmoles (Osm) of solute per kilogram of solvent (osmol/kg or Osm/kg), osmolarity (with an r) is defined as the number of osmoles of solute per liter (L) of solution (osmol/L or Osm/L). As such, larger numbers indicate a greater concentration of solutes in the plasma. Osmolality can be measured on an analytical instrument called an osmometer. It works on the method of depression of freezing point. Osmolarity is affected by changes in water content, as well as temperature and pressure. In contrast, osmolality is independent of temperature and pressure. For a given solution, osmolarity is slightly less than osmolality, because the total solvent weight (the divisor used for ...
The serum osmolality calculator determines blood osmolarity, by using the BUN, glucose and ethanol value and the equation that delivers the mOsm/Kg answer.
View Notes - PSY260_CHP9 from PSYCH 260 at Penn State. a. Diabetes Mellitus b. Osmoreceptors 12. The OVLT and Osmoreception 13. Mechanisms of Hypovolemic Thirst a. Heart, Kideys, and Baroreceptors
The yield strength dependence on strain rate was studied for molybdenum-alloy nanofibers with varying initial dislocation density at three different pre-strain levels. In-situ tensile experiments at three displacement rates were carried out in a scanning electron microscope. Yield strength and its scatter decreased as a function of the pre-strain level for different displacement rates. A statistical model was used to analyze the results, and a negative strain rate dependence was inferred from the yield experiments. This finding suggests the need for theoretical investigations since classical models such as dynamic strain aging may have limitations at such nanoscales. ...
The mean age was: 30.6±7.7 years in the LASEK group (n=33), 34.3±8.7 in LASIK (n=34), 34.6±8.6 in FSBK (n=35), 67.3±11 in the glaucoma treated patients (n=18), 70.6±8 in the senile population (n=73), and 46,3±16,9 years in normals. We did not find statistically significant differences in the mean osmolarity values between groups (p=0.8) (LASEK=304.7±20.2 mOsm/L, LASIK=306.7±17.7 mOsm/L, FSBK=307.8±17.6 mOsm/L, Senile population=306.6±14.1 mOsm/L, glaucoma=310.1±11.7 mOsm/L, normal mean value=300.8±7.8 mOsm/L). No differences were found when comparing the percentage of hyperosmolar eyes (>312mOsm/L) between groups (p=0.3) (LASEK=30,3%, LASIK=44,1%, FSBK=37.1%, Senile=32.8%, glaucoma=55.5 ...
Ca2+ uptake in brush-border vesicles isolated from rat duodena was studied by a rapid-filtration technique. Ca2+ uptake showed saturation kinetics, was dependent on the pH and ionic strength of the medium and was independent of metabolic energy. Uptake activity was readily inhibited by Ruthenium Red, La3+, tetracaine, EGTA, choline chloride and Na+ or K+. The effect of variations in medium osmolarity on Ca2+ uptake and the ionophore A23187-induced efflux of the cation from preloaded vesicles indicated that the Ca2+-uptake process involved binding to membrane components, as well as transport into an osmotically active space. Scatchard-plot analyses of the binding data suggested at least two classes of Ca2+-binding sites. The high-affinity sites, Ka = (2.7 +/- 1.1) x 10(4) M-1 (mean +/- S.D.) bound 3.2 +/- 0.8 nmol of Ca2+/mg of protein, whereas the low-affinity sites (Ka = 60 +/- 6 M-1) bound 110 +/- 17 nmol of Ca2+/mg of protein. In the presence of 100 mM-NaCl, 1.7 and 53 nmol of Ca2+/mg of ...
In DHYD, serum osmolality increased at 3% (p = 0.005) and 5% (p , 0.001) ETBW losses, while FR decreased serum osmolality at the 5% loss of ETBW time point (p = 0.009). In DHYD, KE muscle volume declined from 1,464 ± 446 ml to 1,406 ± 425 ml (3.9%, p , 0.001) at 3% ETBW loss and to 1,378 ± 421 ml (5.9%, p , 0.001) at 5% ETBW loss. The largest decline in KE volume in DYHD occurred in the mid-belly (31 ml, p = 0.001) and proximal (24 ml, p = 0.001) regions of the grouped vasti muscles. There were no changes in volume for the biceps/triceps (p = 0.35) or deltoid (p = 0.92) during DHYD. FR prevented the loss of KE muscle volume at 3% (1,430 ± 435 ml, p = 0.074) and 5% (1,431 ± 439 ml, p = 0.156) ETBW loss time points compared to baseline (1,445 ± 436 ml).. ...
Each of the four test identities was used as an adapter-with itself and each of the other three other identities as probes. The adapting images were the 6 anti-expressions for each identity, and the probe was always the identity prototype for the relevant identity. To keep testing sessions to within an hour, each experimental session comprised testing one identity adapter (with each of its six anti-expressions), with an identity-congruent probe (i.e., the same identity as the adapter) and one identity-incongruent probe. In half of the sessions, the incongruent probe was the same sex as the adapter; in the other half, it was the opposite sex. To test all combinations of adapters and probes, 12 different session types were required. Each participant completed one session, and each session type was completed by four participants with adapters at 100% strength and by two participants with adapters at 50% and 25% strength. The inclusion of the 25% adapter strength condition is an important ...
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Guardian Safety & Supply is a safety company who understands OSHA, ANSI, DOT and NFPA regulations and how they affect you. We were established in 2000 and continue to help our customers stay compliant and more importantly keep their employees safe. We have a large inventory to help provide the service levels you need to run your business and the pricing to keep you within budgets. Most orders ship same day and our experienced staff are ready to help in every way we can.
The kidneys can normally concentrate urine to an Osmolality of , 800 mmol/kg within 12 h of fluid restriction (Water deprivation test).. Comparison of serum and urine osmolalities may help to determine the cause of polyuria, to diagnose SIADH and to distinguish pre-renal from renal causes of impaired renal function.. See Osmolality.. ...
Urine density has long been considered as a practical surrogate marker of urine osmolality. It has even been proposed that simple equations be used in clinical practice to obtain Uosm directly from UD [8-11], whereas a website offers such calculations online [12]. In the present study, we challenged the concept that UD is a reliable marker of urine osmolality. For better accuracy, UD measurements were made utilizing a refractometer, instead of the semi-quantitative dipstick method more commonly employed. Even so, the correlation obtained between UD and Uosm, though statistically significant, was relatively weak (r = 0.462). A closer examination casts serious doubts about the clinical usefulness of UD. If an UD of 1.020 kg/L or higher were regarded as a test to detect individuals with an Uosm of at least 600 mOsm/kg [8-10], the sensitivity of such a test would be only 36%, whereas its specificity would be 81%. In other words, 64% of the subjects with concentrated urines would be missed by such ...
nbsp;Osmolality (ℓ) is the number of osmoles (Osm) of solute per kilogram of solvent (mOsmol/kg), it is measured using an osmometer. This value is not affected by temperature and pressure. This differs from [[Osmolarity,Osmolarity]] (r) which is the number of osmoles of solute per litre of solution (mOsmol/L) and is affected by changes in water content, temperature and pressure. The difference between the actual osmolality and the calculated osmolality is known as the osmotic gap ,ref>Patient. Osmolality, Osmolarity and Fluid Homeostasis. 2016 [cited: 05/12/17]; Available from: https://patient.info/doctor/osmolality-osmolarity-and-fluid-homeostasis,/ref> . ,references ...
The global fitting of the aggregation curves above provides an explanation of the observed changes in half times and scaling exponents: the differential effect of a change in ionic strength on the rates of the individual processes in the aggregation reaction leads to shifts in the dominant mechanism of aggregate multiplication. In order to rationalize this difference in susceptibility to electrostatic shielding we consider the variation of each rate constant with ionic strength. In the plots in Fig. 6a and b we show the logarithm of the various rate constant versus the square root of ionic strength (this latter value includes the contribution from the added salt as well as the buffer; in the absence of added salt the buffer alone (4 mM sodium phosphate, 40 uM EDTA, pH 8.0) results in an ionic strength of approximately 12 mM). In a simple Debye-Hückel (DH)16,32-34 model of the effect of ionic strength, these points would be expected to lie on a straight line. However, DH is accurate only at low ...
Information from ISBN 0-19-963142-5 pg 321. 1) Chose the pH range you want. Use a buffer that is within pK± 1 because the buffering capacity will be low outside that range. The range that is used may be varied if it is known that a buffer has only to counter the effects of acid or base but not both. (Is only H+ produced?) The edge of a working range can be more satisfactorily used if the change in pH is towards the pK. 2) Stability of the buffer, whether it interacts with the substrates, cofactors, or metal ions, the temperature coefficients of its pK, the ionic strength at which it is used, its absorbance in the UV region of the spectrum, its cost, and its availability free from contaminants. Most of the newer zwitterionic buffers do not appreciably bind divalent metal ions, are chemically stable, do not appreciably absorb light at wavelengths longer than 240nm, and can be made up as a concentrated stock solutions. Many of the buffers which have been in longer use have one or more ...
Information from ISBN 0-19-963142-5 pg 321. 1) Chose the pH range you want. Use a buffer that is within pK± 1 because the buffering capacity will be low outside that range. The range that is used may be varied if it is known that a buffer has only to counter the effects of acid or base but not both. (Is only H+ produced?) The edge of a working range can be more satisfactorily used if the change in pH is towards the pK. 2) Stability of the buffer, whether it interacts with the substrates, cofactors, or metal ions, the temperature coefficients of its pK, the ionic strength at which it is used, its absorbance in the UV region of the spectrum, its cost, and its availability free from contaminants. Most of the newer zwitterionic buffers do not appreciably bind divalent metal ions, are chemically stable, do not appreciably absorb light at wavelengths longer than 240nm, and can be made up as a concentrated stock solutions. Many of the buffers which have been in longer use have one or more ...
In the yeast, Saccharomyces cerevesiae, phosphorelay signaling systems that involve a three-step His-Asp-His-Asp phosphotransfer are involved in transmitting signals in response to cellular stress. The animation shows one example of such a phosphorelay system involved in yeast responses to changes in osmolarity. Under conditions of low osmolarity, a histidine-aspartate phosphorelay pathway transmits information that deactivates one signaling pathway and activates gene expression through another pathway. In response to high osmolarity, the Sln1 kinase that initiates the phosphorelay is inhibited and the Hog1 mitogen-activated protein kinase cascade is active. ...
Tytu : Osmotic concentration of gooseberry fruits - the influence of temperature, time, and pretreatment methods on mass transfer and total polyphenol and organic acid content. ...
Sterility tests are performed on each lot of medium using current USP methods. Each lot of medium is also checked for its ability to support the growth of several different cell lines using both sequential subcultures and plating efficiencies. Additional test results are listed in the Certificate of Analysis. Test* Specification pH 7.0 to 7.4 Osmolality 246 to 306 mOsm/kg H 2 O Sterility Testing Pass Endotoxin ≤ 0.5 EU/mL Mycoplasma Pass Growth Promotion Pass *Please consult the Certificate of Analysis for lot-specific test results.
Online molarity calculator from Sigma-Aldrich.com makes calculating molarity and normality for common acid and base stock solutions easy with most common values pre-populated.
Doctors give unbiased, helpful information on indications, contra-indications, benefits, and complications: Dr. Legha on porphyrins fractionated plasma: These refer to the concentration of electrolytes in the body/plasma, or the electrolyte-water balance. These measure the same thing, only that osmolality is the number of osmoles per kilogram of solvent or osm/kg, while osmolarity is the number of osmoles per liter of solution or osm/ltr. Osmolality excludes the solute, while osmolarity includes it, so osmolality has a slightly higher reading.
Yeast cells are exposed to a wide variety of environment stresses, among them changes in the osmotic conditions. An osmolar upshift leads to fast loose of intracellular water, so living cells have developed mechanisms to ...
cellular edema edema attributable to the entry of water into your cells, causing them to swell. This may manifest because of lowered osmolality in the fluid surrounding the cells, as in hypotonic fluid overload, or greater osmolality on the intracellular fluid, as in situations that decrease the exercise with the sodium pump of the cell membrane, letting the focus of sodium ions within the cell to boost ...
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✅ Answered - [isotonic] [hypertonic] [hypotonic] [None of the above] are the options of mcq question Two solutions with the same osmolarity are realted topics , Transport in Plant topics with 0 Attempts, 0 % Average Score, 1 Topic Tagged and 0 People Bookmarked this question which was asked on Feb 23, 2019 19:01
quote=In a problem that involves M1V1=M2V2 you must first identify which you are trying to solve for. If you are solving for final molarity, you know that the molarity the problem gives is the initial molarity. Of the two volumes, the one that comes first is usually the initial volume. If it does not state explicitly what the final volume is, you usually add the amount of water added to the solution to the initial volume to get the final volume ...
Sunum: Periferal uygulama için 1440 ml, 1920 ml, 2400 mllik infüzyon torbaları. Ozmolarite: Ozmolarite: 750 mosm/L. Raf Ömrü: 24 Ay. Karışımlar buzdolabında 2-6ºCde 6 gün ve takip eden 24 saat süresince 25ºC oda sıcaklığında stabil kalır ...
Low osmolar contrast medium with concentration of 300 mg/ml is used. The subject lies down in supine position. An 18G butterfly ... Low osmolar contrast agent with concentration of 240 mg/ml is preferable in this study. Before the procedure, oedematous leg, ...
... or low osmolar contrast material (LOCM) can be used. 10 to 20 ml of LOCM can be used at a concentration of 270 to 300 mg/ml. ...
Either high osmolar contrast medium or low osmolar contrast medium can be used (with concentration of 150 mg/ml). Low density ... Low osmolar contrast medium is used in this procedure with concentration of 150 mg/ml with 20 to 60 ml volume. Those who ... is performed on the 10th day post operation where either high osmolar or low osmolar contrast media with concentration of 150 ...
... (INN), sold under the brand name Isovue among others, is a nonionic, low-osmolar iodinated contrast agent, developed ... It is available in various concentrations, from 200 to 370 mgI/mL. Iopamidol is indicated for angiography throughout the ...
A low osmolar contrast agent with concentration of 200 to 300 mg per ml with volume of 20 ml can be used in this study. Warming ...
Concentrations vary from low to normal to high. High concentrations are used rarely in medicine but frequently in molecular ... Since NaCl dissociates into two ions - sodium and chloride - 1 molar NaCl is 2 osmolar. Thus, NS contains 154 mEq/L of Na+ and ... was the concentration of salt in human blood (rather than 0.6%, the true concentration). Normal saline has become widely used ... Higher and lower concentrations may also occasionally be used. Saline is acidic, with a pH of 5.5 (due mainly to dissolved ...
Low osmolar contrast medium with concentration of 300 mg/ml is used instead of gastrografin if there is risk of aspiration or ... Barium sulfate suspension such as 100 ml or more of E-Z HD 200 to 250% concentration and Baritop 100% can be used. Water- ...
Characteristic concentrations of sodium in model organisms are: 10mM in E. coli, 30mM in budding yeast, 10mM in mammalian cell ... as water moves suddenly into cells with high osmolar content. In humans, a high-salt intake was demonstrated to attenuate ... Sodium is also the principal cation in seawater, although the concentration there is about 3.8 times what it is normally in ... "Cell Biology by the Numbers: What are the concentrations of different ions in cells?". book.bionumbers.org. Retrieved 8 March ...
The resulting "osmolar gap" can be thought of as either osmolar or osmolal, since both units have been used in its derivation.[ ... However, at low concentrations (below about 500 mM), the mass of the solute is negligible compared to the mass of the solvent, ... The osmolar gap is the difference between the measured osmolality and the calculated osmolarity. The difference in units is ... Osmotic concentration Urine osmolality Serum Osmolarity vs. Osmolality "Osmolality," Lab Tests Online, accessed 2012-01-11. ...
... osmolar concentration MeSH H01.181.529.641 - oxidation-reduction MeSH H01.181.529.665 - particle size MeSH H01.181.529.687 - ... hydrogen-ion concentration MeSH H01.181.529.428.176 - acid-base equilibrium MeSH H01.181.529.428.500 - isoelectric point MeSH ...
In a study performed in 1974, it was determined that the optimal osmolar concentration for growth in C. meneghiniana in a ... Marine diatoms and algae in general tend to flourish in higher osmolar concentrations due to the increased presence of carbon ... Nutrient concentration in the habitats of Cyclotella spp. varies. C. sensulato has been described as a dominant member of both ... and concentration. Frustules contain areolas, that is orifices that mediate the passage of nutrients and exudates across the ...
Either high osmolar contrast agent such as diatrizoate or low osmolar contrast agent such as Iotalamic acid with concentration ...
... and the approved dosing regimen maintains therapeutic concentrations without the need to monitor blood concentrations of the ... However, a normal osmolar gap does not rule out ethylene glycol exposure because of wide individual variability. The increased ... Additionally low calcium concentrations in the blood, overactive muscle reflexes, muscle spasms, QT interval prolongation, and ... Additionally, as a side effect of the first two steps of metabolism, an increase in the blood concentration of lactic acid ...
As ions leave the lumen via the Na-K-2Cl symporter and the Na-H antiporter, the concentration becomes more and more hypotonic ... As flow increases, the ability of the loop to maintain its osmolar gradient is reduced. The vasa recta (capillary loops) also ... The 300 mOsm/L fluid from the loop loses water to the higher concentration outside the loop and increases in tonicity until it ... This gives the lumen of the fluid in the loop a positive charge in comparison and creates a Na concentration gradient, which ...
... "osmolar"), in the same way that the molarity of a solution is expressed as "M" (pronounced "molar"). Whereas molarity measures ... Osmotic concentration, formerly known as osmolarity, is the measure of solute concentration, defined as the number of osmoles ( ... separating two solutions of different osmotic concentration. The unit of osmotic concentration is the osmole. This is a non-SI ... also known as osmotic concentration). In simpler terms, osmolality is an expression of solute osmotic concentration per mass of ...
It is in the low osmolar family. Iohexol was approved for medical use in 1985. It is on the World Health Organization's List of ... It is available in various concentrations, from 140[citation needed] to 350 milligrams of iodine per milliliter. World Health ...
The old radiocontrast agents caused anaphylaxis in 1% of cases while the newer, low-osmolar agents cause reactions in 0.01-0.04 ... These are frequently the same as the intravenous contrast agents, merely diluted to approximately 10% of the concentration. ...
Those with history of asthma will have six-fold increased risk to low-osmolar contrast media and 10-fold increased risk to high ... These contrast agents are sold as clear, colorless water solutions, with the concentration usually expressed as mg I/ml. Modern ... The most significant study, proving that injections of ionic (high osmolar) agents are at least as safe as the newer, very ... Anaphylaxis to ionic (high osmolar) contrast agent injections occurred in two clusters of reactions on two occasions (1983 and ...
... high concentrations of ATP, and high concentrations of NADH. Divalent cations like Mg2+ also inhibit MPT, because they can ... draw water in by increasing the organelle's osmolar load. This event may lead mitochondria to swell and may cause the outer ... However, these factors cannot open the pore without Ca2+, though at high enough concentrations, Ca2+ alone can induce MPT. ... The presence of free radicals, another result of excessive intracellular calcium concentrations, can also cause the MPT pore to ...
In salt intoxication, the urine sodium concentrations are very high and fractional excretion of sodium is greater than 1%. ... ADH secretion is one of the primary mechanisms by which sodium and osmolar homeostasis are regulated, ADH is also secreted when ... Patients may have mild stable elevations of serum sodium concentrations, along with elevations in both BUN and creatinine ... It involves an increased osmolality or concentration of solute in the urine, which stimulates secretion of antidiuretic hormone ...
Extravascular extravasation of radiographic contrast media: effects of conventional and low-osmolar agents in the rat thigh. ... due to the higher concentration of CO2. In that sense, venous blood has a greater ability to reflect light. When an arterial- ...
Molecules begin to interact as their concentration increases. During absorption, water must be absorbed at a rate commensurate ... "A randomized controlled trial of glucose versus amylase resistant starch hypo-osmolar oral rehydration solution for adult acute ... Adding viscous polysaccharides to carbohydrate meals can reduce post-prandial blood glucose concentrations. Wheat and maize but ... The variables include chemical structure, polymer concentration, molecular weight, degree of chain branching, the extent of ...
The current standard (hypo-osmolar) WHO ORS, with lower sodium and glucose content, was developed in order to reduce the ... The reduced osmolarity oral rehydration solution has lower concentrations of glucose and sodium chloride than the original ... solution, but the concentrations of potassium and citrate are unchanged. The reduced osmolarity solution has been criticized by ...
... which increases its osmolar load and draws water into the area. Increased porosity of blood vessels also facilitates the entry ... active chemicals that play an important role in wound healing are modeled with Fickian diffusion to generate concentration ...
Amro OW, Paulus JK, Noubary F, Perrone RD (December 2016). "Low-Osmolar Diet and Adjusted Water Intake for Vasopressin ... which in turn is suggested to increase due to secondary effects from an increased intracellular concentration of cyclic AMP ( ...
When the concentration of substrate in the solution is too high, then osmolar forces carry water into the gut lumen and ... more appropriate concentrations of carbohydrate. The sodium concentrations of the fluids have also increased compared with ... With the use of glucose or amino acid substrates for sodium cotransport, there is a limit to the concentration of substrate ... In another study, four different oral solutions with sodium concentrations ranging from 30 to 90 mmol/L were administered to ...
Osmolar Concentration [‎1]‎. Osteoarthritis [‎1]‎. Osteoporosis [‎3]‎. Otitis Media [‎2]‎. Outcome and Process Assessment, ...
Ethylene glycol is odorless and thus, odor does not provide any warning of hazardous concentrations. Ethylene glycol vapor is ... An osmolar gap can be present early after ingestion; this represents unmetabolized ethylene glycol. It will resolve as ... It is available as fomepizole (Antizol) in packages of 1.5 mL vials (concentration = 1 g/1 mL). Each vial is diluted to 100 mL ... Flammable range: 3.2% to 21.6% (concentration in air). Incompatibilities. Ethylene glycol reacts with strong oxidizers and ...
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Osmolar Concentration [‎1]‎. Osteoarthritis [‎1]‎. Osteomalacia [‎16]‎. Osteomyelitis [‎3]‎. Osteopathic Medicine [‎1]‎. ...
Osmolar Concentration * Psychiatric Status Rating Scales * Schizophrenia / chemically induced * Schizophrenia / metabolism* * ...
Osmolality use Osmolar Concentration Osmolar Concentration Osmolarity use Osmolar Concentration Osmometry Osmoregulation ...
Na concentration]) + (glucose concentration/18) + (BUN concentration/2.8). An osmolar gap of 22-25 mOsm/kg results for every ... The predicted concentration of ethanol is calculated using the following equation: Ethanol concentration = (osmolar gap - 10) X ... The osmolar gap can provide information about the ethanol concentration in the blood. ... A normal osmolar gap is 2 ± 6 mOsm/kg; 95% of the population have osmolar gaps between -14 and +10 mOsm/kg. ...
The pH may have been adjusted with glacial acetic acid to 6.5 (6.0 to 7.0). The osmolar concentration is 8 mOsmol/mL (calc); ... It comprises more than 90% of total cations at its normal plasma concentration of approximately 140 mEq/L. The sodium ion ... can cause fluid and/or solute overloading resulting in dilution of other serum electrolyte concentrations, overhydration, ...
When the concentration of substrate in the solution is too high, then osmolar forces carry water into the gut lumen and ... more appropriate concentrations of carbohydrate. The sodium concentrations of the fluids have also increased compared with ... With the use of glucose or amino acid substrates for sodium cotransport, there is a limit to the concentration of substrate ... In another study, four different oral solutions with sodium concentrations ranging from 30 to 90 mmol/L were administered to ...
An osmolar gap ,10 mmoles/L suggests that the serum propylene glycol concentration is high enough to cause toxicity (Barnes et ... However, the osmolar gap, anion gap, and lactate are commonly elevated in propylene glycol intoxication (Lim et al. 2014). ... An osmolar gap at 48 hours after continuous infusion strongly predicts propylene glycol accumulation. An elevated anion gap and ... Renal dysfunction (e.g., increased serum creatinine concentrations, proximal renal tubular cell injury, etc.) (Yaucher et al. ...
The total osmolar concentration of this product is approximately 2,000 mOsm/L. ...
... osmolar clearance decreased and urine flow was unchanged. There was no change in plasma aldosterone concentration, which was ... The blood glucose concentration was not significantly altered, and there was no change in the filtered load of glucose; ... There was also a statistically significant but small reduction in plasma phosphate concentration which was not considered ... and plasma aldosterone concentration. The effect of insulin on CH2O suggests that insulins effect on sodium excretion is due ...
Osmolar Concentration 97% * Electric Impedance 94% * Body Water 66% * Stroke 63% * Water 26% ...
When the concentration of substrate in the solution is too high, then osmolar forces carry water into the gut lumen and ... more appropriate concentrations of carbohydrate. The sodium concentrations of the fluids have also increased compared with ... With the use of glucose or amino acid substrates for sodium cotransport, there is a limit to the concentration of substrate ... In another study, four different oral solutions with sodium concentrations ranging from 30 to 90 mmol/L were administered to ...
First, the plasma concentration of ethylene glycol is 25 mg/dL or more. Second, the patient has a definite history of recent ... though patients with potentially toxic ethylene glycol ingestions may have an apparently normal osmolar gap; see Workup/ ... Hodgman M, Marraffa JM, Wojcik S, Grant W. Serum Calcium Concentration in Ethylene Glycol Poisoning. J Med Toxicol. 2017 Jun. ... Obtain a ethylene glycol serum concentration if you have access to this at your institution or locally. ...
... "osmolar concentration", "urinalysis", "body water", "biological marker" including MESH-terms. In total 229 articles were ...
Osmolar Concentration, Quantitative Trait Loci/physiology",. author = "Scott, {Robert A} and Vasiliki Lagou and Welch, {Ryan P ... Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on ... Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on ... Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on ...
In the absence of a methanol concentration, the osmolal/osmolar gap may be informative (Grade 1D) ... Assuming Tl concentrations are readily available, if Tl concentration is between 0.4 and 1.0 mg/L (3D) ... Assuming Tl concentrations are readily available, if Tl concentration is ,1.0 mg/L (2D) ... Serum methanol concentration greater than 500 mg/L or 15.6 mmol/L in the absence of an ADH blocker (Grade 1D) ...
... elicited osmolar concentration - dependent relaxations of MCh (3 x 10^-7 M) - contracted IPT when applied to the mucosal ...
Osmolar Concentration Medicine & Life Sciences 26% * Cations Medicine & Life Sciences 25% * Terminology Medicine & Life ...
Clinical Relevance-Administration of insulin as a bolus in addition to hypo-osmolar fluids has been advocated in the management ... and blood glucose and sodium concentrations were successfully lowered. Neurologic deficits resolved with treatment, and the ... Treatment and Outcome-A constant rate infusion of regular insulin was administered with hypo-osmolar fluids to treat HOS, ... Treatment and Outcome-A constant rate infusion of regular insulin was administered with hypo-osmolar fluids to treat HOS, and ...
Osmolar Concentration 13% * Taiwan 12% * Hypoglycemia 12% * Hypoglycemic Agents 12% * Cold Temperature 11% ...
Osmolar Concentration 8% * Aneurysm 7% * Smooth Muscle Myocytes 7% * Reactive Oxygen Species 6% ...
Osmolar Concentration. J. S. Kanodia, Kim, Y., Tomer, R., Khan, Z., Chung, K., Storey, J. D., Lu, H., Keller, P. J., and ...
Osmolar Concentration 11% * Radio 11% * Phospholipids 9% * Glycoproteins 9% * Membrane Proteins 9% ...
Osmolar Concentration 19% 7 Scopus citations * Effects of inhibitory and excitatory amino acid neurotransmitters on isolated ...
Osmolar Concentration 17% * Staining and Labeling 16% * Immunoassay 8% * Routine Diagnostic Tests 7% ...
Osmolality use Osmolar Concentration Osmolar Concentration Osmolarity use Osmolar Concentration Osmometry Osmoregulation ...
  • The serum ethanol concentration determined to obtain a starting level. (medscape.com)
  • An osmolar gap of 22-25 mOsm/kg results for every 100 mg/dL of ethanol in the serum. (medscape.com)
  • The intravenous administration of this solution (after appropriate dilution) can cause fluid and/or solute overloading resulting in dilution of other serum electrolyte concentrations, overhydration, congested states or pulmonary edema. (nih.gov)
  • Obtain a ethylene glycol serum concentration if you have access to this at your institution or locally. (medscape.com)
  • 1) The renal tubular damage occurred even by infusion and extraction of cryoprotectant without freezing, because of the hyper-osmolar gradient. (kyoto-u.ac.jp)
  • The best DRBF was obtained in slow freezing and rapid thawing of the kidney which was infused with gradual increase of concentration and extracted with gradual decrease of concentration using 20% DMSO. (kyoto-u.ac.jp)
  • The maximal plasma concentrations in humans occur within 1 hour after ingestion. (cdc.gov)
  • Sufficient blood recirculation of the kidney was not obtained after perfusion of glycerol due to severe outflow block, however this circulating disturbance was steadily diminished by infusion with gradual increase of concentration and extraction with gradual decrease of concentration using 20% DMSO. (kyoto-u.ac.jp)
  • The osmolar gap is calculated using the following equation: gap = measured osmolality - (2 X [Na concentration]) + (glucose concentration/18) + (BUN concentration/2.8). (medscape.com)
  • It has also been reported that children with cerebral palsy present increased salivary osmolality and total protein concentration 10 , together with increased salivary, urine and plasma osmolalities, characterizing an impaired hydration status 11 . (bvsalud.org)
  • Mineralocorticoid treatment also increased plasma sodium, osmolality, and vasopressin concentration (p less than 0.001). (austin.org.au)
  • Urea and osmolality displayed strong individuality in daily urines, whereas sodium (when results were expressed in output terms), urate, potassium, and total protein (when results were expressed in concentration units) had intra-individual variances larger than interindividual variances. (edu.au)
  • 95% of the population have osmolar gaps between -14 and +10 mOsm/kg. (medscape.com)
  • The total osmolar concentration of this product is approximately 2,000 mOsm/L. (neogen.com)
  • It comprises more than 90% of total cations at its normal plasma concentration of approximately 140 mEq/L. The sodium ion exerts a primary role in controlling total body water and its distribution. (nih.gov)
  • The effects of insulin on the renal handling of sodium, potassium, calcium, and phosphate were studied in man while maintaining the blood glucose concentration at the fasting level by negative feedback servocontrol of a variable glucose infusion. (jci.org)
  • Degree of saltiness, which is largely the OSMOLAR CONCENTRATION of SODIUM CHLORIDE plus any other SALTS present. (childrensmercy.org)
  • Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium. (clustermed.info)
  • As has been observed previously with NaCl and KCl, solutions made hypertonic with urea, mannitol, N-methyl-D-glucamine-Cl (NMDG) and Na-gluconate (Glu) elicited osmolar concentration - dependent relaxations of MCh (3 x 10^-7 M) - contracted IPT when applied to the mucosal surface. (cdc.gov)
  • The v(o) value was largely dependent on the KCl concentration but the α value was not. (elsevier.com)
  • DOSAGE AND ADMINISTRATION The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. (clustermed.info)
  • In studies on six water-loaded normal subjects in a steady state of water diuresis, insulin was administered i.v. to raise the plasma insulin concentration to between 98 and 193 muU/ml and infused at a constant rate of 2 mU/kg body weight per min over a total period of 120 min. (jci.org)
  • Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. (maastrichtuniversity.nl)
  • There was also a statistically significant but small reduction in plasma phosphate concentration which was not considered sufficient alone to account for the large reduction in UPV. (jci.org)
  • The dissociation velocity of thick filaments at a sarcomere length of 2.75 μm increased with increasing the KCl concentration (from 60 mM to 0.5 M), increasing the pH value (from 6.2 to 8.0) or decreasing the temperature (from 25 to 5°C) in the presence of 10 mM pyrophosphate and 5 mM MgCl 2 . (elsevier.com)
  • These studies demonstrate a reduction in UNaV associated with insulin administration that occurs in the absence of changes in the filtered load of glucose, glomerular filtration rate, renal blood flow, and plasma aldosterone concentration. (jci.org)
  • Continuous sampling of cerebrospinal fluid (CSF) over 24-h periods in 10 rhesus monkeys revealed a 2-fold, highly reproducible circadian rhythm in CRF concentrations. (ox.ac.uk)
  • osmolar clearance decreased and urine flow was unchanged. (jci.org)
  • Ethylene glycol is odorless and thus, odor does not provide any warning of hazardous concentrations . (cdc.gov)
  • A blood alcohol concentration (BAC) that could make one person apneic may be a level at which another individual would suffer withdrawal. (medscape.com)
  • The osmolar gap can provide information about the ethanol concentration in the blood. (medscape.com)
  • Children with cerebral palsy present low unstimulated salivary flow rate, pH and buffer capacity 8 , and variations in the activity of enzymes and sialic acid concentrations 9 . (bvsalud.org)
  • There was no change in plasma aldosterone concentration, which was low throughout the studies, and a slight reduction was observed in plasma glucagon concentration. (jci.org)
  • The change in UKV was associated with a significant reduction in plasma potassium concentration. (jci.org)
  • However, a subsequent transient could still be elicited on injection of very large concentrations of InsP3. (ox.ac.uk)
  • 5) The canine kidneys were infused with gradual increase of concentration and extracted with gradual decrease of concentration using 20% DMSO and freezed at slow rate and thawed at rapid rate. (kyoto-u.ac.jp)
  • As can be noted from this reaction, increased carbon dioxide (CO 2 ) concentration drives the reaction to the right, whereas a decrease in CO 2 concentration drives it to the left. (medscape.com)
  • CO 2 concentration is maintained within a narrow range via the respiratory drive, which eliminates accumulating CO 2 . (medscape.com)
  • The law of mass action states that the velocity of a reaction is proportional to the product of the reactant concentrations. (medscape.com)
  • At concentrations between these two values a latency was observed. (ox.ac.uk)
  • However, 100-fold greater InsP3 concentrations gave slow, larger Ca2+ transients (and HRs) with no detectable latency. (ox.ac.uk)
  • This equation may provide a gross estimate of the predicted level but varies based on the baseline osmolar gap. (medscape.com)
  • Odor does not provide any warning of hazardous concentrations. (cdc.gov)