Osmolar Concentration
Guanfacine
Mannitol
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
Adrenergic alpha-2 Receptor Antagonists
Diuresis
Hypertonic Solutions
Adrenergic alpha-2 Receptor Agonists
Naltrexone
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Prazosin
Kidney
Blood Urea Nitrogen
The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Receptors, Adrenergic, alpha-2
A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.
Sodium
Glomerular Filtration Rate
Adrenergic alpha-Antagonists
Water
Potassium
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Increased insensible water loss in newborn infants nursed under radiant heaters. (1/9547)
Urine osmolality was studied in 38 babies nursed in conventional incubators or cots and 18 nursed under an overhead radiant heat shield. Among 50 babies receiving a similar fluid intake in the first 48 hours of life mean urinary osmolality was significantly higher in the radiant heater group. In babies weighing less than 1500 g a trend towards higher urinary osmolalities was recorded in those nursed under radiant heaters even though they had received amost double the fluid intake of the incubator group. Severe hypernatraemia occurred in four of the five babies weighing less than 1000 g who were nursed under radiant heaters but in none of the seven babies of similar birth weight nursed in incubators. These findings are consistent with previous observations of an increase in insensible water loss in babies nursed under radiant heaters and emphasise the importance of providing enough extra water for these infants and the need for close monitoring of their fluid balance. The latter may be done at the bedside by measuring urinary specific gravity with a hand refractometer. (+info)Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. (2/9547)
It has been controversial whether high water permeability in the thin descending limb of Henle (TDLH) is required for formation of a concentrated urine by the kidney. Freeze-fracture electron microscopy (FFEM) of rat TDLH has shown an exceptionally high density of intramembrane particles (IMPs), which were proposed to consist of tetramers of aquaporin-1 (AQP1) water channels. In this study, transepithelial osmotic water permeability (Pf) was measured in isolated perfused segments (0.5-1 mm) of TDLH in wild-type (+/+), AQP1 heterozygous (+/-), and AQP1 null (-/-) mice. Pf was measured at 37 degrees C using a 100 mM bath-to-lumen osmotic gradient of raffinose, and fluorescein isothiocyanate (FITC)-dextran as the luminal volume marker. Pf was (in cm/s): 0.26 +/- 0.02 ([+/+]; SE, n = 9 tubules), 0.21 +/- 0.01 ([+/-]; n = 12), and 0.031 +/- 0.007 ([-/-]; n = 6) (P < 0.02, [+/+] vs. [+/-]; P < 0.0001, [+/+] vs. [-/-]). FFEM of kidney medulla showed remarkably fewer IMPs in TDLH from (-/-) vs. (+/+) and (+/-) mice. IMP densities were (in microm-2, SD, 5-12 micrographs): 5,880 +/- 238 (+/+); 5,780 +/- 450 (+/-); and 877 +/- 420 (-/-). IMP size distribution analysis revealed mean IMP diameters of 8.4 nm ([+/+] and [+/-]) and 5.2 nm ([-/-]). These results demonstrate that AQP1 is the principal water channel in TDLH and support the view that osmotic equilibration along TDLH by water transport plays a key role in the renal countercurrent concentrating mechanism. The similar Pf and AQP1 expression in TDLH of (+/+) and (+/-) mice was an unexpected finding that probably accounts for the unimpaired urinary concentrating ability in (+/-) mice. (+info)Relaxin is a potent renal vasodilator in conscious rats. (3/9547)
The kidneys and other nonreproductive organs vasodilate during early gestation; however, the "pregnancy hormones" responsible for the profound vasodilation of the renal circulation during pregnancy are unknown. We hypothesized that the ovarian hormone relaxin (RLX) contributes. Therefore, we tested whether the administration of RLX elicits renal vasodilation and hyperfiltration in conscious adult, intact female rats. After several days of treatment with either purified porcine RLX or recombinant human RLX 2 (rhRLX), effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) increased by 20%-40%. Comparable renal vasodilation and hyperfiltration was also observed in ovariectomized rats, suggesting that estrogen and progesterone are unnecessary for the renal response to rhRLX. The nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyl ester completely abrogated the increase in ERPF and GFR elicited by chronic administration of purified porcine RLX. In contrast, the renal vasoconstrictory response to angiotensin II was attenuated by the RLX treatment. Short-term infusion of purified porcine RLX to conscious rats over several hours failed to increase ERPF and GFR. Plasma osmolality was consistently reduced by the chronic administration of both RLX preparations. In conclusion, the renal and osmoregulatory effects of chronic RLX administration to conscious rats resemble the physiological changes of pregnancy in several respects: (a) marked increases in ERPF and GFR with a mediatory role for nitric oxide; (b) attenuation of the renal circulatory response to angiotensin II; and (c) reduction in plasma osmolality. (+info)The sodium concentration of enteral diets does not influence absorption of nutrients but induces intestinal secretion of water in miniature pigs. (4/9547)
Contradictory opinions exist as to whether the sodium concentration of enteral diets influences absorption of macronutrients and transepithelial movement of sodium and water. Therefore, we investigated the effects of various sodium concentrations of enteral diets on absorption of macronutrients and on net fluxes of sodium and water. In unanesthetized miniature pigs, a 150-cm jejunal segment was perfused with an oligopeptide (Peptisorb), an oligomeric and a polymeric diet. The polymeric diet was supplemented with pancreatic enzymes. The sodium concentrations varied between 30 and 150 mmol/L. The energy density was 3.4 MJ/L. The sodium concentration of the diets did not influence absorption of macronutrients and of total energy. However, increasing sodium concentrations of the diets were associated with increasing osmolality of the solutions, resulting in a linear increase in net secretion of water and flow rate of chyme. With all diets and sodium concentrations net secretion of sodium occurred. The sodium secretion was independent of the initial sodium concentration of the diets. It was linearly correlated with net flux of water and was largest in miniature pigs infused with the oligomeric diet. The sodium concentration of the jejunal effluent did not correspond to the initial sodium concentration of the diets. The present results indicate that enteral feeding of diets with high energy density inevitably increases net secretion of water and sodium as sodium concentration increases. Therefore, the sodium concentration of diets should be as low as possible to meet only the minimal daily requirement of sodium. Low sodium concentrations of diets have no negative effects on absorption of macronutrients. (+info)Treating the syndrome of inappropriate ADH secretion with isotonic saline. (5/9547)
It has been widely accepted that there is little use for saline treatment in the syndrome of inappropriate secretion of ADH (SIADH). However, having observed that most SIADH patients increased their plasma sodium (PNa) after 2 l isotonic saline over 24 h, we investigated whether urine osmolality or the sum of urinary sodium and potassium (UNa + K) predicted this response, in 17 consecutive patients with chronic SIADH. The initial measure of urinary sodium plus potassium (UNa + K t0) was weakly correlated to the change in PNa (DPNa) after infusion (r = -0.51; p < 0.05), while initial urine osmolality (UOSM t0) was a much better predictor (y = -0.024x + 12.90; r = -0.81; p < 0.001). The lack of predictive value for UNa + K t0 was probably because urine electrolyte concentrations were not maximal for the corresponding initial UOSM. This reflects differences in salt intake between the patients. The theoretical maximal value for UNa + K t0 (th max UNa + K t0) for a given USOM t0, was as good a predictor as UOSM t0 (th max UNa + K vs. DPNa: r = -0.81; p < 0.001). A theoretical model describing the effect of 2 l isotonic saline infusion on DPNa as a function of UNa + K, produced values comparable to those observed in our patients. Only 6/17 patients, those with UOSM > 530 mOsm/kg, had their hyponatraemia aggravated by 2 l isotonic saline. Many SIADH patients have lower UOSM; in most such patients, 2 l of isotonic saline will improve PNa. (+info)MENT, a heterochromatin protein that mediates higher order chromatin folding, is a new serpin family member. (6/9547)
Terminal cell differentiation is correlated with the extensive sequestering of previously active genes into compact transcriptionally inert heterochromatin. In vertebrate blood cells, these changes can be traced to the accumulation of a developmentally regulated heterochromatin protein, MENT. Cryoelectron microscopy of chicken granulocyte chromatin, which is highly enriched with MENT, reveals exceptionally compact polynucleosomes, which maintain a level of higher order folding above that imposed by linker histones. The amino acid sequence of MENT reveals a close structural relationship with serpins, a large family of proteins known for their ability to undergo dramatic conformational transitions. Conservation of the "hinge region" consensus in MENT indicates that this ability is retained by the protein. MENT is distinguished from the other serpins by being a basic protein, containing several positively charged surface clusters, which are likely to be involved in ionic interactions with DNA. One of the positively charged domains bears a significant similarity to the chromatin binding region of nuclear lamina proteins and with the A.T-rich DNA-binding motif, which may account for the targeting of MENT to peripheral heterochromatin. MENT ectopically expressed in a mammalian cell line is transported into nuclei and is associated with intranuclear foci of condensed chromatin. (+info)A method for analyzing enzyme kinetics with substrate activation and inhibition and its application to the alpha-chymotrypsin-catalyzed hydrolysis of phenyl acetates. (7/9547)
A general kinetic method was developed to analyze enzyme-catalyzed systems complicated by the presence of activation or inhibition by substrate. The method was applied to the alpha-chymotrypsin [EC 3.4.21.1]-catalyzed hydrolysis of p-chlorophenyl and p-methoxyphenyl acetates. Deacylation rate constants which were not complicated by substrate activation were obtained. The analysis shows that the abnormal substituent dependence of kcat in the steady state hydrolysis is due not to substrate activation but to inappropriateness of the two-step mechanism or the existence of more than one acetyl-enzyme intermediate. (+info)H5 Histone and DNA-relaxing enzyme of chicken erythrocytes. Interaction with superhelical DNA. (8/9547)
The interaction of closed circular duplex DNA with the lysine-rich H5 histone fraction of avian erythrocytes has been studied. H5, like H1 histone, interacts preferentially with superhelical DNA. The extent of interaction increases with increasing negative or positive superhelicity. Salt-extracted lysine-rich histones show the same specificity for interaction with superhelices as do acid-extracted preparations. Chicken erythrocyte nuclei contain DNA-relaxing enzyme. This enzyme is extracted from the nuclei at lower salt concentrations than those required to extract H1 and H5 histones and is, therefore, probably a function of a protein distinct from H1 and H5 histones. (+info)
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Guardian Safety & Supply is the industrial strength solution for your safety and supply needs
Guardian Safety & Supply is the industrial strength solution for your safety and supply needs
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Lidstrom:Buffers - OpenWetWare
Lidstrom:Buffers - OpenWetWare
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RPMI-1640 Medium ATCC ® 30-2001™
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Two solutions with the same osmolarity are
formula units - CHEMISTRY COMMUNITY
Kabiven® Peripheral - Fresenius Kabi Türkiye
Venography
Low osmolar contrast medium with concentration of 300 mg/ml is used. The subject lies down in supine position. An 18G butterfly ... Low osmolar contrast agent with concentration of 240 mg/ml is preferable in this study. Before the procedure, oedematous leg, ...
Hysterosalpingography
... or low osmolar contrast material (LOCM) can be used. 10 to 20 ml of LOCM can be used at a concentration of 270 to 300 mg/ml. ...
Percutaneous transhepatic cholangiography
Either high osmolar contrast medium or low osmolar contrast medium can be used (with concentration of 150 mg/ml). Low density ... Low osmolar contrast medium is used in this procedure with concentration of 150 mg/ml with 20 to 60 ml volume. Those who ... is performed on the 10th day post operation where either high osmolar or low osmolar contrast media with concentration of 150 ...
Iopamidol
... (INN), sold under the brand name Isovue among others, is a nonionic, low-osmolar iodinated contrast agent, developed ... It is available in various concentrations, from 200 to 370 mgI/mL. Iopamidol is indicated for angiography throughout the ...
Retrograde urethrogram
A low osmolar contrast agent with concentration of 200 to 300 mg per ml with volume of 20 ml can be used in this study. Warming ...
Saline (medicine)
Concentrations vary from low to normal to high. High concentrations are used rarely in medicine but frequently in molecular ... Since NaCl dissociates into two ions - sodium and chloride - 1 molar NaCl is 2 osmolar. Thus, NS contains 154 mEq/L of Na+ and ... was the concentration of salt in human blood (rather than 0.6%, the true concentration). Normal saline has become widely used ... Higher and lower concentrations may also occasionally be used. Saline is acidic, with a pH of 5.5 (due mainly to dissolved ...
Upper gastrointestinal series
Low osmolar contrast medium with concentration of 300 mg/ml is used instead of gastrografin if there is risk of aspiration or ... Barium sulfate suspension such as 100 ml or more of E-Z HD 200 to 250% concentration and Baritop 100% can be used. Water- ...
Sodium in biology
Characteristic concentrations of sodium in model organisms are: 10mM in E. coli, 30mM in budding yeast, 10mM in mammalian cell ... as water moves suddenly into cells with high osmolar content. In humans, a high-salt intake was demonstrated to attenuate ... Sodium is also the principal cation in seawater, although the concentration there is about 3.8 times what it is normally in ... "Cell Biology by the Numbers: What are the concentrations of different ions in cells?". book.bionumbers.org. Retrieved 8 March ...
Plasma osmolality
The resulting "osmolar gap" can be thought of as either osmolar or osmolal, since both units have been used in its derivation.[ ... However, at low concentrations (below about 500 mM), the mass of the solute is negligible compared to the mass of the solvent, ... The osmolar gap is the difference between the measured osmolality and the calculated osmolarity. The difference in units is ... Osmotic concentration Urine osmolality Serum Osmolarity vs. Osmolality "Osmolality," Lab Tests Online, accessed 2012-01-11. ...
List of MeSH codes (H01)
... osmolar concentration MeSH H01.181.529.641 - oxidation-reduction MeSH H01.181.529.665 - particle size MeSH H01.181.529.687 - ... hydrogen-ion concentration MeSH H01.181.529.428.176 - acid-base equilibrium MeSH H01.181.529.428.500 - isoelectric point MeSH ...
Cyclotella
In a study performed in 1974, it was determined that the optimal osmolar concentration for growth in C. meneghiniana in a ... Marine diatoms and algae in general tend to flourish in higher osmolar concentrations due to the increased presence of carbon ... Nutrient concentration in the habitats of Cyclotella spp. varies. C. sensulato has been described as a dominant member of both ... and concentration. Frustules contain areolas, that is orifices that mediate the passage of nutrients and exudates across the ...
Voiding cystourethrography
Either high osmolar contrast agent such as diatrizoate or low osmolar contrast agent such as Iotalamic acid with concentration ...
Ethylene glycol poisoning
... and the approved dosing regimen maintains therapeutic concentrations without the need to monitor blood concentrations of the ... However, a normal osmolar gap does not rule out ethylene glycol exposure because of wide individual variability. The increased ... Additionally low calcium concentrations in the blood, overactive muscle reflexes, muscle spasms, QT interval prolongation, and ... Additionally, as a side effect of the first two steps of metabolism, an increase in the blood concentration of lactic acid ...
Loop of Henle
As ions leave the lumen via the Na-K-2Cl symporter and the Na-H antiporter, the concentration becomes more and more hypotonic ... As flow increases, the ability of the loop to maintain its osmolar gradient is reduced. The vasa recta (capillary loops) also ... The 300 mOsm/L fluid from the loop loses water to the higher concentration outside the loop and increases in tonicity until it ... This gives the lumen of the fluid in the loop a positive charge in comparison and creates a Na concentration gradient, which ...
Osmotic concentration
... "osmolar"), in the same way that the molarity of a solution is expressed as "M" (pronounced "molar"). Whereas molarity measures ... Osmotic concentration, formerly known as osmolarity, is the measure of solute concentration, defined as the number of osmoles ( ... separating two solutions of different osmotic concentration. The unit of osmotic concentration is the osmole. This is a non-SI ... also known as osmotic concentration). In simpler terms, osmolality is an expression of solute osmotic concentration per mass of ...
Iohexol
It is in the low osmolar family. Iohexol was approved for medical use in 1985. It is on the World Health Organization's List of ... It is available in various concentrations, from 140[citation needed] to 350 milligrams of iodine per milliliter. World Health ...
CT scan
The old radiocontrast agents caused anaphylaxis in 1% of cases while the newer, low-osmolar agents cause reactions in 0.01-0.04 ... These are frequently the same as the intravenous contrast agents, merely diluted to approximately 10% of the concentration. ...
Iodinated contrast
Those with history of asthma will have six-fold increased risk to low-osmolar contrast media and 10-fold increased risk to high ... These contrast agents are sold as clear, colorless water solutions, with the concentration usually expressed as mg I/ml. Modern ... The most significant study, proving that injections of ionic (high osmolar) agents are at least as safe as the newer, very ... Anaphylaxis to ionic (high osmolar) contrast agent injections occurred in two clusters of reactions on two occasions (1983 and ...
Mitochondrial permeability transition pore
... high concentrations of ATP, and high concentrations of NADH. Divalent cations like Mg2+ also inhibit MPT, because they can ... draw water in by increasing the organelle's osmolar load. This event may lead mitochondria to swell and may cause the outer ... However, these factors cannot open the pore without Ca2+, though at high enough concentrations, Ca2+ alone can induce MPT. ... The presence of free radicals, another result of excessive intracellular calcium concentrations, can also cause the MPT pore to ...
Adipsia
In salt intoxication, the urine sodium concentrations are very high and fractional excretion of sodium is greater than 1%. ... ADH secretion is one of the primary mechanisms by which sodium and osmolar homeostasis are regulated, ADH is also secreted when ... Patients may have mild stable elevations of serum sodium concentrations, along with elevations in both BUN and creatinine ... It involves an increased osmolality or concentration of solute in the urine, which stimulates secretion of antidiuretic hormone ...
Venous translucence
Extravascular extravasation of radiographic contrast media: effects of conventional and low-osmolar agents in the rat thigh. ... due to the higher concentration of CO2. In that sense, venous blood has a greater ability to reflect light. When an arterial- ...
Dietary fiber
Molecules begin to interact as their concentration increases. During absorption, water must be absorbed at a rate commensurate ... "A randomized controlled trial of glucose versus amylase resistant starch hypo-osmolar oral rehydration solution for adult acute ... Adding viscous polysaccharides to carbohydrate meals can reduce post-prandial blood glucose concentrations. Wheat and maize but ... The variables include chemical structure, polymer concentration, molecular weight, degree of chain branching, the extent of ...
Oral rehydration therapy
The current standard (hypo-osmolar) WHO ORS, with lower sodium and glucose content, was developed in order to reduce the ... The reduced osmolarity oral rehydration solution has lower concentrations of glucose and sodium chloride than the original ... solution, but the concentrations of potassium and citrate are unchanged. The reduced osmolarity solution has been criticized by ...
Wound healing
... which increases its osmolar load and draws water into the area. Increased porosity of blood vessels also facilitates the entry ... active chemicals that play an important role in wound healing are modeled with Fickian diffusion to generate concentration ...
Autosomal dominant polycystic kidney disease
Amro OW, Paulus JK, Noubary F, Perrone RD (December 2016). "Low-Osmolar Diet and Adjusted Water Intake for Vasopressin ... which in turn is suggested to increase due to secondary effects from an increased intracellular concentration of cyclic AMP ( ...
IMSEAR at SEARO: Search
1 Osmolar Concentration. *. next > Date issued. *1 1972. IMSEAR is the collaborative product of Health Literature, Library and ...
Acute Diarrhea in Children: Oral Rehydration, Maint., Nutr. Therapy
When the concentration of substrate in the solution is too high, then osmolar forces carry water into the gut lumen and ... more appropriate concentrations of carbohydrate. The sodium concentrations of the fluids have also increased compared with ... With the use of glucose or amino acid substrates for sodium cotransport, there is a limit to the concentration of substrate ... In another study, four different oral solutions with sodium concentrations ranging from 30 to 90 mmol/L were administered to ...
IMSEAR at SEARO: Search
1 Hydrogen-Ion Concentration. *1 Liver --enzymology. *1 Muramidase --isolation & purifica.... *1 Osmolar Concentration ...
Browsing Technical Documents by Subject
Osmolar Concentration [1]. Osteoarthritis [1]. Osteoporosis [3]. Otitis Media [2]. Outcome and Process Assessment, ...
Ethylene Glycol | Medical Management Guidelines | Toxic Substance Portal | ATSDR
Ethylene glycol is odorless and thus, odor does not provide any warning of hazardous concentrations. Ethylene glycol vapor is ... An osmolar gap can be present early after ingestion; this represents unmetabolized ethylene glycol. It will resolve as ... It is available as fomepizole (Antizol) in packages of 1.5 mL vials (concentration = 1 g/1 mL). Each vial is diluted to 100 mL ... Flammable range: 3.2% to 21.6% (concentration in air). Incompatibilities. Ethylene glycol reacts with strong oxidizers and ...
Browsing by Subject "Osmolar Concentration"
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Psychotic exacerbations and enhanced vasopressin secretion in schizophrenic patients with hyponatremia and polydipsia
DeCS 2013 - December 17, 2013 version
Pediatric Ethanol Toxicity Workup: Laboratory Studies, Imaging Studies
Na concentration]) + (glucose concentration/18) + (BUN concentration/2.8). An osmolar gap of 22-25 mOsm/kg results for every ... The predicted concentration of ethanol is calculated using the following equation: Ethanol concentration = (osmolar gap - 10) X ... The osmolar gap can provide information about the ethanol concentration in the blood. ... A normal osmolar gap is 2 ± 6 mOsm/kg; 95% of the population have osmolar gaps between -14 and +10 mOsm/kg. ...
DailyMed - SODIUM ACETATE injection, solution, concentrate
The pH may have been adjusted with glacial acetic acid to 6.5 (6.0 to 7.0). The osmolar concentration is 8 mOsmol/mL (calc); ... It comprises more than 90% of total cations at its normal plasma concentration of approximately 140 mEq/L. The sodium ion ... can cause fluid and/or solute overloading resulting in dilution of other serum electrolyte concentrations, overhydration, ...
The Management of Acute Diarrhea in Children:
Oral Rehydration, Maintenance, and Nutritional Therapy
When the concentration of substrate in the solution is too high, then osmolar forces carry water into the gut lumen and ... more appropriate concentrations of carbohydrate. The sodium concentrations of the fluids have also increased compared with ... With the use of glucose or amino acid substrates for sodium cotransport, there is a limit to the concentration of substrate ... In another study, four different oral solutions with sodium concentrations ranging from 30 to 90 mmol/L were administered to ...
Ethylene Glycol and Propylene Glycol Toxicity: What is Propylene Glycol? | Environmental Medicine | ATSDR
An osmolar gap ,10 mmoles/L suggests that the serum propylene glycol concentration is high enough to cause toxicity (Barnes et ... However, the osmolar gap, anion gap, and lactate are commonly elevated in propylene glycol intoxication (Lim et al. 2014). ... An osmolar gap at 48 hours after continuous infusion strongly predicts propylene glycol accumulation. An elevated anion gap and ... Renal dysfunction (e.g., increased serum creatinine concentrations, proximal renal tubular cell injury, etc.) (Yaucher et al. ...
Animal Health | Safe and Effective Products | Neogen
JCI -
Comments
... osmolar clearance decreased and urine flow was unchanged. There was no change in plasma aldosterone concentration, which was ... The blood glucose concentration was not significantly altered, and there was no change in the filtered load of glucose; ... There was also a statistically significant but small reduction in plasma phosphate concentration which was not considered ... and plasma aldosterone concentration. The effect of insulin on CH2O suggests that insulins effect on sodium excretion is due ...
The diagnostic accuracy of multi-frequency bioelectrical impedance analysis in diagnosing dehydration after stroke -...
Acute Diarrhea in Children: Oral Rehydration, Maint., Nutr. Therapy
When the concentration of substrate in the solution is too high, then osmolar forces carry water into the gut lumen and ... more appropriate concentrations of carbohydrate. The sodium concentrations of the fluids have also increased compared with ... With the use of glucose or amino acid substrates for sodium cotransport, there is a limit to the concentration of substrate ... In another study, four different oral solutions with sodium concentrations ranging from 30 to 90 mmol/L were administered to ...
Ethylene Glycol Toxicity Treatment & Management: Approach Considerations, Prehospital Care, Emergency Department Care
First, the plasma concentration of ethylene glycol is 25 mg/dL or more. Second, the patient has a definite history of recent ... though patients with potentially toxic ethylene glycol ingestions may have an apparently normal osmolar gap; see Workup/ ... Hodgman M, Marraffa JM, Wojcik S, Grant W. Serum Calcium Concentration in Ethylene Glycol Poisoning. J Med Toxicol. 2017 Jun. ... Obtain a ethylene glycol serum concentration if you have access to this at your institution or locally. ...
Validación de métodos de ingesta de bebidas frente a biomarcadores de hidratación: pequeña revisión
Pharmaceutics and Drug Delivery Centre - Research output - University of Huddersfield Research Portal
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying...
Osmolar Concentration, Quantitative Trait Loci/physiology",. author = "Scott, {Robert A} and Vasiliki Lagou and Welch, {Ryan P ... Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on ... Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on ... Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on ...
Search Results
UKidney - Toxicology primer
In the absence of a methanol concentration, the osmolal/osmolar gap may be informative (Grade 1D) ... Assuming Tl concentrations are readily available, if Tl concentration is between 0.4 and 1.0 mg/L (3D) ... Assuming Tl concentrations are readily available, if Tl concentration is ,1.0 mg/L (2D) ... Serum methanol concentration greater than 500 mg/L or 15.6 mmol/L in the absence of an ADH blocker (Grade 1D) ...
NIOSHTIC-2 Search Results - Full View
International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential Channels<...
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Clinical Relevance-Administration of insulin as a bolus in addition to hypo-osmolar fluids has been advocated in the management ... and blood glucose and sodium concentrations were successfully lowered. Neurologic deficits resolved with treatment, and the ... Treatment and Outcome-A constant rate infusion of regular insulin was administered with hypo-osmolar fluids to treat HOS, ... Treatment and Outcome-A constant rate infusion of regular insulin was administered with hypo-osmolar fluids to treat HOS, and ...
Visual hallucinations in 246-km mountain ultra-marathoners: An observational study - Fingerprint - Taipei Medical...
Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis - Fingerprint - Mayo...
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Stimulation of frequency of MEPPs at the frog neuromuscular junction by extracellular EGTA<...
Allan-Hermann Pool - Research output - University of Texas Southwestern Medical Center
Isolation and compositional analysis of secretion granules and their membrane subfraction from the rat parotid gland -...
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Tear biomarker analysis as a diagnostic tool for dry eye disease - Fingerprint
- ResearchOnline
Serum4
- The serum ethanol concentration determined to obtain a starting level. (medscape.com)
- An osmolar gap of 22-25 mOsm/kg results for every 100 mg/dL of ethanol in the serum. (medscape.com)
- The intravenous administration of this solution (after appropriate dilution) can cause fluid and/or solute overloading resulting in dilution of other serum electrolyte concentrations, overhydration, congested states or pulmonary edema. (nih.gov)
- Obtain a ethylene glycol serum concentration if you have access to this at your institution or locally. (medscape.com)
Freezing2
- 1) The renal tubular damage occurred even by infusion and extraction of cryoprotectant without freezing, because of the hyper-osmolar gradient. (kyoto-u.ac.jp)
- The best DRBF was obtained in slow freezing and rapid thawing of the kidney which was infused with gradual increase of concentration and extracted with gradual decrease of concentration using 20% DMSO. (kyoto-u.ac.jp)
Ingestion1
- The maximal plasma concentrations in humans occur within 1 hour after ingestion. (cdc.gov)
Kidney1
- Sufficient blood recirculation of the kidney was not obtained after perfusion of glycerol due to severe outflow block, however this circulating disturbance was steadily diminished by infusion with gradual increase of concentration and extraction with gradual decrease of concentration using 20% DMSO. (kyoto-u.ac.jp)
Osmolality4
- The osmolar gap is calculated using the following equation: gap = measured osmolality - (2 X [Na concentration]) + (glucose concentration/18) + (BUN concentration/2.8). (medscape.com)
- It has also been reported that children with cerebral palsy present increased salivary osmolality and total protein concentration 10 , together with increased salivary, urine and plasma osmolalities, characterizing an impaired hydration status 11 . (bvsalud.org)
- Mineralocorticoid treatment also increased plasma sodium, osmolality, and vasopressin concentration (p less than 0.001). (austin.org.au)
- Urea and osmolality displayed strong individuality in daily urines, whereas sodium (when results were expressed in output terms), urate, potassium, and total protein (when results were expressed in concentration units) had intra-individual variances larger than interindividual variances. (edu.au)
MOsm2
- 95% of the population have osmolar gaps between -14 and +10 mOsm/kg. (medscape.com)
- The total osmolar concentration of this product is approximately 2,000 mOsm/L. (neogen.com)
Sodium4
- It comprises more than 90% of total cations at its normal plasma concentration of approximately 140 mEq/L. The sodium ion exerts a primary role in controlling total body water and its distribution. (nih.gov)
- The effects of insulin on the renal handling of sodium, potassium, calcium, and phosphate were studied in man while maintaining the blood glucose concentration at the fasting level by negative feedback servocontrol of a variable glucose infusion. (jci.org)
- Degree of saltiness, which is largely the OSMOLAR CONCENTRATION of SODIUM CHLORIDE plus any other SALTS present. (childrensmercy.org)
- Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium. (clustermed.info)
Dependent3
- As has been observed previously with NaCl and KCl, solutions made hypertonic with urea, mannitol, N-methyl-D-glucamine-Cl (NMDG) and Na-gluconate (Glu) elicited osmolar concentration - dependent relaxations of MCh (3 x 10^-7 M) - contracted IPT when applied to the mucosal surface. (cdc.gov)
- The v(o) value was largely dependent on the KCl concentration but the α value was not. (elsevier.com)
- DOSAGE AND ADMINISTRATION The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. (clustermed.info)
Insulin concentration2
- In studies on six water-loaded normal subjects in a steady state of water diuresis, insulin was administered i.v. to raise the plasma insulin concentration to between 98 and 193 muU/ml and infused at a constant rate of 2 mU/kg body weight per min over a total period of 120 min. (jci.org)
- Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. (maastrichtuniversity.nl)
Phosphate1
- There was also a statistically significant but small reduction in plasma phosphate concentration which was not considered sufficient alone to account for the large reduction in UPV. (jci.org)
Temperature1
- The dissociation velocity of thick filaments at a sarcomere length of 2.75 μm increased with increasing the KCl concentration (from 60 mM to 0.5 M), increasing the pH value (from 6.2 to 8.0) or decreasing the temperature (from 25 to 5°C) in the presence of 10 mM pyrophosphate and 5 mM MgCl 2 . (elsevier.com)
Glucose1
- These studies demonstrate a reduction in UNaV associated with insulin administration that occurs in the absence of changes in the filtered load of glucose, glomerular filtration rate, renal blood flow, and plasma aldosterone concentration. (jci.org)
Fluid1
- Continuous sampling of cerebrospinal fluid (CSF) over 24-h periods in 10 rhesus monkeys revealed a 2-fold, highly reproducible circadian rhythm in CRF concentrations. (ox.ac.uk)
Urine1
- osmolar clearance decreased and urine flow was unchanged. (jci.org)
Ethylene1
- Ethylene glycol is odorless and thus, odor does not provide any warning of hazardous concentrations . (cdc.gov)
Blood2
- A blood alcohol concentration (BAC) that could make one person apneic may be a level at which another individual would suffer withdrawal. (medscape.com)
- The osmolar gap can provide information about the ethanol concentration in the blood. (medscape.com)
Enzymes1
- Children with cerebral palsy present low unstimulated salivary flow rate, pH and buffer capacity 8 , and variations in the activity of enzymes and sialic acid concentrations 9 . (bvsalud.org)
Plasma2
Injection1
- However, a subsequent transient could still be elicited on injection of very large concentrations of InsP3. (ox.ac.uk)
Decrease2
- 5) The canine kidneys were infused with gradual increase of concentration and extracted with gradual decrease of concentration using 20% DMSO and freezed at slow rate and thawed at rapid rate. (kyoto-u.ac.jp)
- As can be noted from this reaction, increased carbon dioxide (CO 2 ) concentration drives the reaction to the right, whereas a decrease in CO 2 concentration drives it to the left. (medscape.com)
Respiratory1
- CO 2 concentration is maintained within a narrow range via the respiratory drive, which eliminates accumulating CO 2 . (medscape.com)
Product1
- The law of mass action states that the velocity of a reaction is proportional to the product of the reactant concentrations. (medscape.com)
Values1
- At concentrations between these two values a latency was observed. (ox.ac.uk)
Greater1
- However, 100-fold greater InsP3 concentrations gave slow, larger Ca2+ transients (and HRs) with no detectable latency. (ox.ac.uk)
Provide2
- This equation may provide a gross estimate of the predicted level but varies based on the baseline osmolar gap. (medscape.com)
- Odor does not provide any warning of hazardous concentrations. (cdc.gov)