Organic Cation Transporter 1: An organic cation transporter found in kidney. It is localized to the basal lateral membrane and is likely to be involved in the renal secretion of organic cations.Organic Cation Transport Proteins: A family of proteins involved in the transport of organic cations. They play an important role in the elimination of a variety of endogenous substances, xenobiotics, and their metabolites from the body.Catecholamine Plasma Membrane Transport Proteins: A group of membrane transport proteins that transport biogenic amine derivatives of catechol across the PLASMA MEMBRANE. Catecholamine plasma membrane transporter proteins regulate neural transmission as well as catecholamine metabolism and recycling.Cations: Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.1-Methyl-4-phenylpyridinium: An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.Equilibrative Nucleoside Transport Proteins: A class of sodium-independent nucleoside transporters that mediate the facilitative transport of NUCLEOSIDES.Tetraethylammonium: A potassium-selective ion channel blocker. (From J Gen Phys 1994;104(1):173-90)Carnitine: A constituent of STRIATED MUSCLE and LIVER. It is an amino acid derivative and an essential cofactor for fatty acid metabolism.Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.Organic Anion Transporters: Proteins involved in the transport of organic anions. They play an important role in the elimination of a variety of endogenous substances, xenobiotics and their metabolites from the body.Organic Anion Transporters, Sodium-Independent: A subclass of ORGANIC ANION TRANSPORTERS that do not rely directly or indirectly upon sodium ion gradients for the transport of organic ions.Organic Anion Transport Protein 1: A polyspecific transporter for organic cations found primarily in the kidney. It mediates the coupled exchange of alpha-ketoglutarate with organic ions such as P-AMINOHIPPURIC ACID.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Octamer Transcription Factor-1: A ubiquitously expressed octamer transcription factor that regulates GENETIC TRANSCRIPTION of SMALL NUCLEAR RNA; IMMUNOGLOBULIN GENES; and HISTONE H2B genes.Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)Pyridinium CompoundsMembrane Transport Proteins: Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.Tetraethylammonium CompoundsKidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.Famotidine: A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.LLC-PK1 Cells: Epithelial cell line originally derived from porcine kidneys. It is used for pharmacologic and metabolic studies.Xenopus laevis: The commonest and widest ranging species of the clawed "frog" (Xenopus) in Africa. This species is used extensively in research. There is now a significant population in California derived from escaped laboratory animals.Ion Transport: The movement of ions across energy-transducing cell membranes. Transport can be active, passive or facilitated. Ions may travel by themselves (uniport), or as a group of two or more ions in the same (symport) or opposite (antiport) directions.Ergothioneine: A naturally occurring metabolite of HISTIDINE that has antioxidant properties.Antiporters: Membrane transporters that co-transport two or more dissimilar molecules in the opposite direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.Biological Transport, Active: The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.Biogenic Monoamines: Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.Kidney Tubules, Proximal: The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.Membrane Transport Modulators: Agents that affect ION PUMPS; ION CHANNELS; ABC TRANSPORTERS; and other MEMBRANE TRANSPORT PROTEINS.Cation Transport Proteins: Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a biological membrane.p-Aminohippuric Acid: The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.Quaternary Ammonium Compounds: Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN=CR2.Cations, Divalent: Positively charged atoms, radicals or groups of atoms with a valence of plus 2, which travel to the cathode or negative pole during electrolysis.Cell Line: Established cell cultures that have the potential to propagate indefinitely.ATP-Binding Cassette Transporters: A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.Kinetics: The rate dynamics in chemical or physical systems.Oocytes: Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).Corticosterone: An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.Cations, Monovalent: Positively charged atoms, radicals or group of atoms with a valence of plus 1, which travel to the cathode or negative pole during electrolysis.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Renal Agents: Drugs used for their effects on the kidneys' regulation of body fluid composition and volume. The most commonly used are the diuretics. Also included are drugs used for their antidiuretic and uricosuric actions, for their effects on the kidneys' clearance of other drugs, and for diagnosis of renal function.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.HEK293 Cells: A cell line generated from human embryonic kidney cells that were transformed with human adenovirus type 5.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Choline: A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Histamine H2 Antagonists: Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.Octamer Transcription Factor-2: An octamer transcription factor expressed primarily in B-LYMPHOCYTES and the developing CENTRAL NERVOUS SYSTEM that regulates GENETIC TRANSCRIPTION of IMMUNOGLOBULIN GENES.Cricetulus: A genus of the family Muridae consisting of eleven species. C. migratorius, the grey or Armenian hamster, and C. griseus, the Chinese hamster, are the two species used in biomedical research.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)CHO Cells: CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.Caco-2 Cells: Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation.P-Glycoprotein: A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).Histamine: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.Inhibitory Concentration 50: The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Symporters: Membrane transporters that co-transport two or more dissimilar molecules in the same direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.Hepatocytes: The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Octamer Transcription Factor-3: An octamer transcription factor that is expressed primarily in totipotent embryonic STEM CELLS and GERM CELLS and is down-regulated during CELL DIFFERENTIATION.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Carbon Radioisotopes: Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.Organoplatinum Compounds: Organic compounds which contain platinum as an integral part of the molecule.Organ Specificity: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Placenta: A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.TritiumHypoglycemic Agents: Substances which lower blood glucose levels.Amantadine: An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Zhu HJ, Appel DI, Gründemann D, Markowitz JS (July 2010). "Interaction of organic cation transporter 3 (SLC22A3) and ... Rytting E, Audus KL (January 2005). "Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma ... The human serotonin transporter and norepinephrine transporter do not contain zinc binding sites. 4-Hydroxyamphetamine has been ... SLC1A1 is excitatory amino acid transporter 3 (EAAT3), a glutamate transporter located in neurons, SLC22A3 is an extraneuronal ...
Lamhonwah, A. M.; Skaug, J.; Scherer, S. W.; Tein, I. (2003). "A third human carnitine/organic cation transporter (OCTN3) as a ... Solute carrier family 22 (organic cation transporter), member 21 is a protein that in the house mouse is encoded by the ... "Solute carrier family 22 (organic cation transporter), member 21". Retrieved 2011-12-11. "Indirect calorimetry data for ... "Molecular and Functional Characterization of Organic Cation/Carnitine Transporter Family in Mice". Journal of Biological ...
... "organic cation transporter, novel, type 1"), but efficiency of transport for organic cations (e.g., tetraethylammonium) is very ... Eraly SA, Hamilton BA, Nigam SK (Jan 2003). "Organic anion and cation transporters occur in pairs of similar and similarly ... Xuan W, Lamhonwah AM, Librach C, Jarvi K, Tein I (Jun 2003). "Characterization of organic cation/carnitine transporter family ... Kawasaki Y, Kato Y, Sai Y, Tsuji A (Dec 2004). "Functional characterization of human organic cation transporter OCTN1 single ...
This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the ... organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules ... "The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of ... "Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)". J. Biol. Chem. 283 (24): 16332-41. ...
... serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in ... Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many ... "Entrez Gene: SLC22A1 solute carrier family 22 (organic cation transporter), member 1". Pryor, R; Cabreiro, F; Haberland, G (16 ... Schinkel AH, Jonker JW (November 2002). "Polymorphisms affecting function of the human organic cation transporter hOCT1 ( ...
... serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in ... Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many ... Barendt WM, Wright SH (2002). "The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization". J. ... 2003). "Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases". Am. J. Physiol. ...
Hsyu PH, Gisclon LG, Hui AC, Giacomini KM (Jan 1988). "Interactions of organic anions with the organic cation transporter in ... Solute carrier family 22 (organic anion/cation transporter), member 12, also known as SLC22A12 and URAT1, is a protein which in ... organic anion/cation transporter), member 12". Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M ... "A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout". ...
Lamhonwah AM, Tein I (Jul 2006). "Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian ...
Hsyu PH, Gisclon LG, Hui AC, Giacomini KM (January 1988). "Interactions of organic anions with the organic cation transporter ... Probenecid interferes with the kidneys' organic anion transporter (OAT), which reclaims uric acid from the urine and returns it ... If probenecid (an organic acid) is present, the OAT binds preferentially to it (instead of to uric acid), preventing ...
"Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18". Akiyama S (December 2001). "[ ... an organic cation transporter expressed in the renal proximal tubules". FEBS Letters. 433 (3): 245-50. doi:10.1016/S0014-5793( ... an imprinted gene similar to polyspecific transporter and multi-drug resistance genes". Human Molecular Genetics. 7 (4): 597- ...
1999). "Mutations in novel organic cation transporter (OCTN2), an organic cation/carnitine transporter, with differential ... 1999). "Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/ ... Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many ... The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium ...
... organic anion/cation transporter), member 9". Zhou F, Hong M, You G (2007). "Regulation of human organic anion transporter 4 by ... 2005). "Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules". J. ... Shin HJ, Anzai N, Enomoto A, He X, Kim do K, Endou H, Kanai Y (Apr 2007). "Novel liver-specific organic anion transporter OAT7 ... 2000). "Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta". J. Biol ...
Eraly SA, Hamilton BA, Nigam SK (2003). "Organic anion and cation transporters occur in pairs of similar and similarly ...
The entry of imatinib into cells is dependent on an organic cation transporter (OCT1). OCT1 plays a significant role in ... transporters that promotes efflux of foreign molecules from cells. Bosutinib even inhibits these transporter proteins in higher ... Nilotinib is also not a substrate for the efflux transporter P-glycoprotein pump, unlike imatinib. Although the two dimensional ...
"Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters". ... "Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters ... "Pharmacological profile of antidepressants and related compounds at human monoamine transporters". Eur. J. Pharmacol. 340 (2-3 ...
"A human transporter protein that mediates the final excretion step for toxic organic cations". Proceedings of the National ... "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations". Trends in Pharmacological Sciences ... MATE2 H+/organic cation antiporter". Morita Y, Kodama K, Shiota S, Mine T, Kataoka A, Mizushima T, Tsuchiya T (July 1998). " ... organic cation antiporters". Biochemical Pharmacology. 74 (2): 359-71. doi:10.1016/j.bcp.2007.04.010. PMID 17509534. Omote H, ...
... the plasma membrane extraneuronal monoamine transporter or organic cation transporter 3 (EMT or SLC22A3), Iversen's uptake2; ... and the vesicular monoamine transporter (VMAT) with two isoforms. Transporters and intracellular enzymes such as monoamine ... They now comprise the plasma membrane noradrenaline transporter (NAT or NET), the classical uptake1, and the analogous dopamine ...
2006). "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations". Trends in Pharmacological ... archaea and eukaryotes function as fundamental transporters of metabolic and xenobiotic organic cations. These proteins are ... NorM is nicknamed "Last of the multidrug transporters" because it is the last multidrug transporter discovered functionally as ... "Structure of a Cation-bound Multidrug and Toxic Compound Extrusion Transporter". Nature. 467 (7318): 991-994. doi:10.1038/ ...
Decynium has been shown to have a very high affinity to organic cation transporters in a variety of species, including human, ... Hayer-Zillgen M, Brüss M, Bönisch H (2002). "Expression and pharmacological profile of the human organic cation transporters ... as well as all members of the organic cation transporter (OCT) family in both human and rat cells. However, it has little ... "Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PK1 cells". J ...
... serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in ... Organic cation transporter 3 is a polyspecific transporter whose transport is independent of sodium. Known substrates for ... 2007). "The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show ... 1999). "Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for ...
2006). "A human transporter protein that mediates the final excretion step for toxic organic cations". Proc. Natl. Acad. Sci. U ... Chen Y, Zhang S, Sorani M, Giacomini KM (2007). "Transport of paraquat by human organic cation transporters and multidrug and ... 2007). "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations". Trends Pharmacol. Sci. 27 ( ... "A human transporter protein that mediates the final excretion step for toxic organic cations". Proc. Natl. Acad. Sci. U.S.A. ...
... and human clarify the phylogeny of organic anion and cation transporters". Physiol. Genomics. 18 (1): 12-24. doi:10.1152/ ... Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is ... "Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family". Genomics. ... Eraly SA; Monte JC; Nigam SK (2004). "Novel slc22 transporter homologs in fly, worm, ...
... the microbe creates organic cation transport proteins, antibiotic-related transporters and heavy-metal ion transporters. Sulcia ...
... encoding an organic cation transporter, is associated with rheumatoid arthritis". Nature Genetics. 35 (4): 341-8. doi:10.1038/ ... These include a fungal phosphate transporter PiPT, plant nitrate transporter NRT1.1, and the human glucose transporter GLUT1. ... Wada S, Tsuda M, Sekine T, Cha SH, Kimura M, Kanai Y, Endou H (September 2000). "Rat multispecific organic anion transporter 1 ... Many MFS transporters are thought to be dimers through in vitro and in vivo methods, with some evidence to suggest a functional ...
HNF-1α is involved in the promotion of hepatic organic cation transporters, which uptake certain classes of pharmaceuticals; ... "Hepatocyte nuclear factor 1 regulates the expression of the organic cation transporter 1 via binding to an evolutionary ... including the involvement in GLUT1 and GLUT2 transporter expression in pancreatic β-cells and angiotensin-converting enzyme 2 ... such as being a transcriptional regulator of bile acid transporters in the intestine and kidneys. ...
4) cation that can itself be substituted similarly; while stibonium (SbH+. 4) itself is not known, some of its organic ... The balance between potassium and sodium is maintained by ion transporter proteins in the cell membrane.[231] The cell membrane ... Potassium is the major cation (positive ion) inside animal cells,[223] while sodium is the major cation outside animal cells.[ ... However, for the alkali metal cations, the second coordination sphere is not well-defined as the +1 charge on the cation is not ...
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... organic cation/carnitine transporter), member 16 (SLC22A16) - 10 µg - RC207954 from OriGene ... SLC22A16 (Myc-DDK-tagged)-Human solute carrier family 22 (organic cation/carnitine transporter), member 16 (SLC22A16) - 10 µg ... SLC22A16 (Myc-DDK-tagged)-Human solute carrier family 22 (organic cation/carnitine transporter), member 16 (SLC22A16). ...
Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation - BioChain ... Home / Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation. ... Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation. Masayo Aoki, ...
The organic cation transporter OCT1 (SLC22A1) mediates the uptake of vitamin B1, cationic drugs, and xenobiotics into ... From: Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter ...
Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic ... ABSTRACT The organic cation/carnitine transporters OCTN1 and OCTN2 are related to other organic cation transporters (OCT1, OCT2 ... Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic ... Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic ...
... organic cation/ergothioneine transporter), member 4 (SLC22A4) available for purchase from OriGene - Your Gene Company. ... Slc22a4 (Myc-DDK-tagged) - Mouse solute carrier family 22 (organic cation transporter), member 4 (Slc22a4). $680. Next day. ... Slc22a4 (untagged) - Mouse solute carrier family 22 (organic cation transporter), member 4 (Slc22a4), (10ug). $190. Next day. ... organic cation/ergothioneine transporter), member 4 (SLC22A4). pCMV6-AC-GFP. pLenti-C-Myc-DDK. pLenti-C-mGFP. $610. In Stock. ...
Clock temporally regulates expression of organic cation transporter 3 (OCT3), which is involved in histamine transport, in mast ... Clock temporally regulates expression of organic cation transporter 3 (OCT3), which is involved in histamine transport, in mast ... Clock temporally regulates expression of organic cation transporter 3 (OCT3), which is involved in histamine transport, in mast ... Clock temporally regulates expression of organic cation transporter 3 (OCT3), which is involved in histamine transport, in mast ...
... a cDNA encoding an organic cation transporter, OCTN2, has been isolated by its homology to the previously identified organic ... Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency. Yuhuan Wang, Jing Ye, Vadivel ... The gene for this condition maps to 5q31.2-32 and OCTN2, an organic cation/carnitine transporter, also maps to the same ... Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency ...
The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as ... This innovative text explores the cellular transport of organic cations, from functional and structural properties to ... Organic Cation Transporters. Book Subtitle. Integration of Physiology, Pathology, and Pharmacology. Editors. * Giuliano ... Organic Cation Transporters. Integration of Physiology, Pathology, and Pharmacology. Editors: Ciarimboli, Giuliano, Gautron, ...
Keywords: interindividual variation, organic cation transporter (OCT), genetic polymorphism, expression level JOURNALS FREE ... and genetic polymorphisms of the organic cation transporter (OCT) family, and the pharmacokinetic or pharmacodynamic ... genetic polymorphism of drug transporters has attracted interest because these transporters play important roles in the ... consequences for organic cationic drugs. Although the clinical significance is still unclear, many studies have reported the ...
Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity. Shuzhong Zhang, Katherine S. Lovejoy, James E. Shima ... Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity. Shuzhong Zhang, Katherine S. Lovejoy, James E. Shima ... Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity. Shuzhong Zhang, Katherine S. Lovejoy, James E. Shima ... The organic cation transporters (OCT) 1 [solute carrier 22A1 (SLC22A1)], 2 (SLC22A2), and 3 (SLC22A3) are in the class of ...
In the present study, we reported that the BIM also blocks activity of the solute carrier organic cation transporter (OCT) 1, ... In addition to activity of OCT1, Ro 31-8220 inhibited those of other organic cation transporters such as multidrug and toxin ... these data extend the nature of cellular off-targets of the BIM Ro 31-8220 to OCT1 and other organic cation transporters, which ... including inhibition of the ATP-binding cassette drug transporter breast cancer resistance protein. ...
... while the organic anion transporters (OATs) and the organic cation transporters (OCTs) are classified in the SLC22A superfamily ... OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies.. Roth M1, Obaidat A ... The human organic anion and cation transporters are classified within two SLC superfamilies. Superfamily SLCO (formerly SLC21A ... OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies ...
J:47780 Koehler MR, et al., The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26. ... J:236752 Sprowl JA, et al., A phosphotyrosine switch regulates organic cation transporters. Nat Commun. 2016 Mar 16;7:10880 ... No significant defects in the renal secretion of a model organic cation are observed. ... IPR036259 MFS transporter superfamily. IPR004749 Organic cation transport protein/SVOP. IPR005829 Sugar transporter, conserved ...
J:227211 Zhang Y, et al., Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015;6:8186 ... IPR036259 MFS transporter superfamily. IPR004749 Organic cation transport protein/SVOP. IPR005829 Sugar transporter, conserved ...
Inhibition of Gene Expression of Organic Cation/Carnitine Transporter and Antioxidant Enzymes in Oxazaphosphorines-Induced ... This study investigated whether oxazaphosphorines alter the expression of organic cation/carnitine transporter (OCTN2) and ...
Altered Pharmacokinetics of Cimetidine Caused by Down-regulation of Renal Rat Organic Cation Transporter 2 (rOCT2) after Liver ... The renal tubular secretion of cationic drugs is dominated by basolateral organic cation transporter 2 (rOCT2/SLC22A2) and ... Little is known about the variation in the expression of these renal transporters after liver ischemia-reperfusion (I/R) injury ...
ABSTRACTAlthough some guanidine compounds were reported as superior substrates for organic cation transporter (OCT)2 than OCT1 ... Although some guanidine compounds were reported as superior substrates for organic cation transporter (OCT)2 than OCT1, it was ... Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2 ...
Investigation of involvement of organic cation transporters (SLC22A1-5). Download Prime PubMed App to iPhone, iPad, or Android ... and to determine the involvement of organic cation transporters (OCTs, SLC22A1-3) and organic cation/carnitine transporter ( ... and to determine the involvement of organic cation transporters (OCTs, SLC22A1-3) and organic cation/carnitine transporter ( ... Organic cation rhodamines for screening organic cation transporters in early stages of drug development. ...
The human organic cation transporter 2 (OCT2) mediates the first step of tubular secretion of most positively charged ... Plasma Membrane Cholesterol Regulates the Allosteric Binding of 1-Methyl-4-Phenylpyridinium to Organic Cation Transporter 2 ( ... Plasma Membrane Cholesterol Regulates the Allosteric Binding of 1-Methyl-4-Phenylpyridinium to Organic Cation Transporter 2 ( ...
1996) Transport of small organic cations in the rat liver. The role of the organic cation transporter OCT1. Naunyn- ... organic cation transporter. MPP+. 1-methyl-4-phenylpyridinium. TMA. tetramethylammonium. TEA. tetraethylammonium. TPrA. ... Organic cation transporters in the kidney and liver play an important role in the removal of potentially toxic drugs and their ... 1998) Molecular cloning and functional expression of a rabbit renal organic cation transporter. Biochim Biophys Acta 1369:1-6. ...
Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone ... via the pyrilamine transporter, a putative organic cation transporter, using conditionally immortalized rat brain capillary ... but not by classic organic cation transporter (OCT) substrates and/or inhibitors (tetraethylammonium, 1-methyl-4- ... These results suggest that blood-brain barrier transport of oxycodone is at least partly mediated by a common transporter with ...
solute carrier family 22 (organic cation transporter), member 3. Synonyms: EMT, Oct3, Orct3. Gene nomenclature, locus ... OMIM: SOLUTE CARRIER FAMILY 22 (EXTRANEURONAL MONOAMINE TRANSPORTER), MEMBER*Gene Ontology: Slc22a3 *Mouse Phenome DB: Slc22a3 ...
Organic cation transporter 1 is responsible for hepatocellular uptake of the tyrosine kinase inhibitor pazopanib. Waleed ... Organic cation transporter 1 is responsible for hepatocellular uptake of the tyrosine kinase inhibitor pazopanib. Waleed ... Organic cation transporter 1 is responsible for hepatocellular uptake of the tyrosine kinase inhibitor pazopanib. Waleed ... Organic cation transporter 1 is responsible for hepatocellular uptake of the tyrosine kinase inhibitor pazopanib ...
Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer. Thorsten ... Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer. Thorsten ... Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer. Thorsten ... Organic cation transporters OCT1 (SLC22A1) and OCT2 (SLC22A2) are critically involved in absorption and excretion of diverse ...
  • Last but not least, some of these transporter proteins can also be envisaged as drug targets, as long as they can show "transceptor" functions, in some cases related to their role as modulators of extracellular adenosine levels, thereby providing a functional link between P1 receptors and transporters. (frontiersin.org)
  • However, the chemical modifications of the nucleoside analogs can alter their ability to interact with canonical transporter proteins implicated in the uptake of natural nucleosides. (frontiersin.org)
  • SLC22A24 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al. (genecards.org)
  • The impact these transporters have on DDIs, as well as the influence they have on the pharmacokinetics of cationic drugs, makes them a focus of efforts to develop models capable of predicting and, ideally, pre-empting unwanted interactions. (grantome.com)
  • Members of the OCT family play essential roles in the handling of cationic drugs and endogenously synthesized organic cations. (diabetesjournals.org)
  • To clarify the considerable interindividual variability in the pharmacokinetics, efficacy, and toxicity of drugs, genetic polymorphism of drug transporters has attracted interest because these transporters play important roles in the gastrointestinal absorption, biliary and renal elimination, and distribution to target sites of their substrates. (go.jp)
  • Several polymorphisms identified in members of these superfamilies have been shown to affect pharmacokinetics of their drug substrates, confirming the importance of these drug transporters for efficient pharmacological therapy. (nih.gov)
  • Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Doxorubicin Pathway, Pharmacokinetics . (genecards.org)
  • This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. (springer.com)
  • Tomi M, Nishimura T, Nakashima E. Mother-to-fetus transfer of antiviral drugs and the involvement of transporters at the placental barrier. (springer.com)