Transference of an organ between individuals of the same species or between individuals of different species.
The transference of a part of or an entire liver from one human or animal to another.
The transference of a kidney from one human or animal to another.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The transference of a heart from one human or animal to another.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
The transference of either one or both of the lungs from one human or animal to another.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
The transference of a pancreas from one human or animal to another.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
Transplantation of an individual's own tissue from one site to another site.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Prospective patient listings for appointments or treatments.
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
A dead body, usually a human body.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Elements of limited time intervals, contributing to particular results or situations.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Travel to another country for the purpose of medical treatment.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
Transplantation between animals of different species.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
Partial or total replacement of the CORNEA from one human or animal to another.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
The immune responses of a host to a graft. A specific response is GRAFT REJECTION.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A component of the PUBLIC HEALTH SERVICE that provides leadership related to the delivery of health services and the requirements for and distribution of health resources, including manpower training.
The return of a sign, symptom, or disease after a remission.
A monotheistic religion promulgated by the Prophet Mohammed with Allah as the deity.
Transference of fetal tissue between individuals of the same species or between individuals of different species.
Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Pathological processes of the LIVER.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The planning and managing of programs, services, and resources.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
The induction of prolonged survival and growth of allografts of either tumors or normal tissues which would ordinarily be rejected. It may be induced passively by introducing graft-specific antibodies from previously immunized donors, which bind to the graft's surface antigens, masking them from recognition by T-cells; or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The interrelationship of medicine and religion.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
The state that distinguishes organisms from inorganic matter, manifested by growth, metabolism, reproduction, and adaptation. It includes the course of existence, the sum of experiences, the mode of existing, or the fact of being. Over the centuries inquiries into the nature of life have crossed the boundaries from philosophy to biology, forensic medicine, anthropology, etc., in creative as well as scientific literature. (Random House Unabridged Dictionary, 2d ed; Dr. James H. Cassedy, NLM History of Medicine Division)
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
The transfer of leukocytes from a donor to a recipient or reinfusion to the donor.
Planning for the equitable allocation, apportionment, or distribution of available health resources.
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
Derivatives of propylene glycol (1,2-propanediol). They are used as humectants and solvents in pharmaceutical preparations.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
Societal or individual decisions about the equitable distribution of available resources.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
The period following a surgical operation.
Antibodies produced by a single clone of cells.
An individual that contains cell populations derived from different zygotes.
Disease having a short and relatively severe course.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A supergroup (some say phylum) of ameboid EUKARYOTES, comprising ARCHAMOEBAE; LOBOSEA; and MYCETOZOA.
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).
Clusters of topics that fall within the domain of BIOETHICS, the field of study concerned with value questions that arise in biomedicine and health care delivery.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.
Centers for acquiring, characterizing, and storing organs or tissue for future use.
Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
Pathological processes of the KIDNEY or its component tissues.
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The application of engineering principles and methods to living organisms or biological systems.
A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
Time period from 1901 through 2000 of the common era.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Conceptual response of the person to the various aspects of death, which are based on individual psychosocial and cultural experience.
The measurement of an organ in volume, mass, or heaviness.
Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
An encapsulated lymphatic organ through which venous blood filters.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
Alteration of the immune system or of an immune response by agents that activate or suppress its function. This can include IMMUNIZATION or administration of immunomodulatory drugs. Immunomodulation can also encompass non-therapeutic alteration of the immune system effected by endogenous or exogenous substances.
The process of observing, recording, or detecting the effects of a chemical substance administered to an individual therapeutically or diagnostically.
Combinations of diagnostic or therapeutic substances linked with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; or ANTIGENS. Often the diagnostic or therapeutic substance is a radionuclide. These conjugates are useful tools for specific targeting of DRUGS and RADIOISOTOPES in the CHEMOTHERAPY and RADIOIMMUNOTHERAPY of certain cancers.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The transference of a complete HAND, as a composite of many tissue types, from one individual to another.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Progenitor cells from which all blood cells derive.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.
Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Time period from 2001 through 2100 of the common era.
The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Virus diseases caused by the HERPESVIRIDAE.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.
Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.
Infections with fungi of the genus ASPERGILLUS.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
A general term for various neoplastic diseases of the lymphoid tissue.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The spiral EPITHELIUM containing sensory AUDITORY HAIR CELLS and supporting cells in the cochlea. Organ of Corti, situated on the BASILAR MEMBRANE and overlaid by a gelatinous TECTORIAL MEMBRANE, converts sound-induced mechanical waves to neural impulses to the brain.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Antibodies obtained from a single clone of cells grown in mice or rats.
A general term for diseases produced by viruses.
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The number of LYMPHOCYTES per unit volume of BLOOD.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.

Should prophylaxis for Pneumocystis carinii pneumonia in solid organ transplant recipients ever be discontinued? (1/1093)

Solid organ transplant recipients are at risk for Pneumocystis carinii pneumonia (PCP), but the risk of PCP beyond 1 year is poorly defined. We identified 25 cases of PCP in 1,299 patients undergoing solid organ transplantation between 1987 and 1996 at The Cleveland Clinic Foundation (4.8 cases per 1,000 person transplant-years [PTY]). Ten (36%) of 28 PCP cases (transplantation was performed before 1987 in three cases) occurred > or = 1 year after transplantation, and no patient developed PCP while receiving prophylaxis for PCP. The incidence of PCP during the first year following transplantation was eight times higher than that during subsequent years. The highest rate occurred among lung transplant recipients (22 cases per 1,000 PTY), for whom the incidence did not decline beyond the first year of transplantation. We conclude that the incidence of PCP is highest during the first year after transplantation and differs by type of solid organ transplant. Extending the duration of PCP prophylaxis beyond 1 year may be warranted for lung transplant recipients.  (+info)

Merkel cell carcinoma and melanoma: etiological similarities and differences. (2/1093)

Merkel cell carcinoma (MCC) of the skin and cutaneous malignant melanoma can now be compared epidemiologically through the use of population-based data not previously available for MCC. The results may provide new clues to etiology. In this study, United States data covered by the Surveillance, Epidemiology, and End Results (SEER) Program were from nine areas of the United States (approximately 10% of the population). In 1986-1994, 425 cases of MCC were registered. The annual age-adjusted incidence per 100,000 of MCC was 0.23 for whites and 0.01 for blacks; among whites, the ratio of melanoma to MCC was approximately 65 to 1. Only 5% of MCC occurred before age 50, unlike the lifelong risk of nodular and superficial spreading melanoma. Regional incidence rates of both cancers increased similarly with increasing sun exposure as measured by the UVB solar index. The most sun-exposed anatomical site, the face, was the location of 36% of MCC but only 14% of melanoma. Both cancers increased in frequency and aggressiveness after immunosuppression and organ transplantation (36 cases from the Cincinnati Transplant Tumor registry and 12 from published case reports) and after B-cell neoplasia (5 cases in this study; 13 from case series in the literature). The SEER data contained reports of six patients with both types of cancer; 5 melanomas before the diagnosis of MCC and 1 after diagnosis. MCC and melanoma are similarly related to sun exposure and immunosuppression, but they differ markedly from one another in their distributions by age, race, and anatomical site, especially the face.  (+info)

Clinical significance of expression of human cytomegalovirus pp67 late transcript in heart, lung, and bone marrow transplant recipients as determined by nucleic acid sequence-based amplification. (3/1093)

Human cytomegalovirus (HCMV) infection was monitored retrospectively by qualitative determination of pp67 mRNA (a late viral transcript) by nucleic acid sequence-based amplification (NASBA) in a series of 50 transplant recipients, including 26 solid-organ (11 heart and 15 lung) transplant recipients (SOTRs) and 24 bone marrow transplant recipients (BMTRs). NASBA results were compared with those obtained by prospective quantitation of HCMV viremia and antigenemia and retrospective quantitation of DNA in leukocytes (leukoDNAemia). On the whole, 29 patients were NASBA positive, whereas 10 were NASBA negative, and the blood of 11 patients remained HCMV negative. NASBA detected HCMV infection before quantitation of viremia did but after quantitation of leukoDNAemia and antigenemia did. In NASBA-positive blood samples, median levels of viremia, antigenemia, and leukoDNAemia were significantly higher than the relevant levels detected in NASBA-negative HCMV-positive blood samples. By using the quantitation of leukoDNAemia as the "gold standard," the analytical sensitivity (47.3%), as well as the negative predictive value (68. 3%), of NASBA for the diagnosis of HCMV infection intermediate between that of antigenemia quantitation (analytical sensitivity, 72. 3%) and that of viremia quantitation (analytical sensitivity, 28.7%), while the specificity and the positive predictive value were high (90 to 100%). However, with respect to the clinically relevant antigenemia cutoff of >/=100 used in this study for the initiation of preemptive therapy in SOTRs with reactivated HCMV infection, the clinical sensitivity of NASBA reached 100%, with a specificity of 68. 9%. Upon the initiation of antigenemia quantitation-guided treatment, the actual median antigenemia level was 158 (range, 124 to 580) in SOTRs who had reactivated infection and who presented with NASBA positivity 3.5 +/- 2.6 days in advance and 13.5 (range, 1 to 270) in the group that included BMTRs and SOTRs who had primary infection (in whom treatment was initiated upon the first confirmation of detection of HCMV in blood) and who presented with NASBA positivity 2.0 +/- 5.1 days later. Following antiviral treatment, the durations of the presence of antigenemia and pp67 mRNA in blood were found to be similar. In conclusion, monitoring of the expression of HCMV pp67 mRNA appears to be a promising, well-standardized tool for determination of the need for the initiation and termination of preemptive therapy. Its overall clinical impact should be analyzed in future prospective studies.  (+info)

Detection of Epstein-Barr virus DNA in sera from transplant recipients with lymphoproliferative disorders. (4/1093)

Early diagnosis of Epstein-Barr Virus (EBV)-associated posttransplant lymphoproliferative disease (PTLD) is important because many patients respond to reduction in immunosuppression, especially if PTLD is detected at an early stage. Previous studies have found elevated EBV DNA levels in blood from patients with PTLD, but these assays required isolation of cellular blood fractions and quantitation. We evaluated the presence of cell-free EBV DNA in serum from solid-organ transplant recipients as a marker for PTLD. Five of 6 transplant recipients with histopathologically documented PTLD had EBV DNA detected in serum at the time of diagnosis (sensitivity = 83%), compared with 0 of 16 matched transplant recipients without PTLD (specificity = 100%) (P < 0.001 [Fisher's exact test]). Furthermore, EBV DNA was detected in serum 8 and 52 months prior to the diagnosis of PTLD in two of three patients for whom stored sera were analyzed. Detection of EBV DNA in serum appears to be a useful marker for the early detection of PTLD in solid-organ transplant recipients. Further studies to define the role of such assays in evaluating solid-organ transplant patients at risk for PTLD are warranted.  (+info)

Cytokine mRNA profiles in Epstein-Barr virus-associated post-transplant lymphoproliferative disorders. (5/1093)

Cytokine mRNA patterns were analyzed in 11 post-transplant lymphoproliferative disorder (PTLD) specimens using qualitative reverse-transcriptase polymerase chain reaction (RT-PCR). In each case, a pattern of IL2-, IFN gamma-, IL4+, IL10+ was seen. A similar pattern was observed in a spleen sample from 1 patient with contemporaneous PTLD elsewhere. Semiquantitative RT-PCR for cytokine message was performed using RNA from bronchoalveolar lavage (BAL) specimens obtained from 2 patients with pulmonary PTLD. In both cases, IL4 message predominated. Reduction of message coincided with resolution of the tumors. The pattern differed from that seen in 1 patient with acute pulmonary rejection, in which RT-PCR of BAL cells showed predominance of IL6 and IFN gamma. We conclude that at least some PTLDs exist within a T-helper cell type 2 (Th2)-like cytokine microenvironment. The presence of a similar mRNA pattern in an extratumoral specimen at the time of PTLD suggests that it may reflect a systemic phenomenon. Disappearance of this pattern following PTLD resolution indicates its dynamic nature and is consistent with the hypothesis that specific cytokines contribute to the development of PTLDs.  (+info)

Identification of glucoside and carboxyl-linked glucuronide conjugates of mycophenolic acid in plasma of transplant recipients treated with mycophenolate mofetil. (6/1093)

1. Mycophenolic acid (MPA), is primarily metabolized in the liver to 7-O-MPA-beta-glucuronide (MPAG). Using RP-h.p.l.c. we observed three further MPA metabolites, M-1, M-2, M-3, in plasma of transplant recipients on MMF therapy. To obtain information on the structure and source of these metabolites: (A) h.p.l.c. fractions containing either metabolite or MPA were collected and analysed by tandem mass spectrometry; (B) the metabolism of MPA was studied in human liver microsomes in the presence of UDP-glucuronic acid, UDP-glucose or NADPH; (C) hydrolysis of metabolites was investigated using beta-glucosidase, beta-glucuronidase or NaOH; (D) cross-reactivity of each metabolite was tested in an immunoassay for MPA (EMIT). 2. Mass spectrometry of M-1, M-2, MPA and MPAG in the negative ion mode revealed molecular ions of m/z 481, m/z 495, m/z 319 and m/z 495 respectively. 3. Incubation of microsomes with MPA and UDP-glucose produced M-1, with MPA and UDP-glucuronic acid MPAG and M-2 were formed, while with MPA and NADPH, M-3 was observed. 4. Beta-Glucosidase hydrolysed M-1 completely. Beta-Glucuronidase treatment led to a complete disappearance of MPAG whereas the amount of M-2 was reduced by approximately 30%. Only M-2 was labile to alkaline treatment. 5. M-2 and MPA but not M-1 and MPAG cross-reacted in the EMIT assay. 6. These results suggest that: (i) M-1 is the 7-OH glucose conjugate of MPA; (ii) M-2 is the acyl glucuronide conjugate of MPA; (iii) M-3 is derived from the hepatic CYP450 system.  (+info)

Epidemiology of visceral mycoses: analysis of data in annual of the pathological autopsy cases in Japan. (7/1093)

The data on visceral mycoses that had been reported in the Annual of the Pathological Autopsy Cases in Japan from 1969 to 1994 by the Japanese Society of Pathology were analyzed epidemiologically. The frequency of visceral mycoses among the annual total number of pathological autopsy cases increased noticeably from 1.60% in 1969 to a peak of 4.66% in 1990. Among them, the incidences of candidiasis and aspergillosis increased the most. After 1990, however, the frequency of visceral mycoses decreased gradually. Until 1989, the predominant causative agent was Candida, followed in order by Aspergillus and Cryptococcus. Although the rate of candidiasis decreased by degrees from 1990, the rate of aspergillosis increased up to and then surpassed that of candidiasis in 1991. Leukemia was the major disease underlying the visceral mycoses, followed by solid cancers and other blood and hematopoietic system diseases. Severe mycotic infection has increased over the reported 25-year period, from 6.6% of the total visceral mycosis cases in 1969 to 71% in 1994. The reasons for this decrease of candidiasis combined with an increase of aspergillosis or of severe mycotic infection might be that (i) nonsevere (not disseminated) infections were excluded from the case totals, since they have become controllable by antifungal drugs such as fluconazole, but (ii) the available antifungal drugs were not efficacious against severe infections such as pulmonary aspergillosis, and (iii) the number of patients living longer in an immunocompromised state had increased because of developments in chemotherapy and progress in medical care.  (+info)

N-acetylcysteine attenuates cyclosporin-induced nephrotoxicity in rats. (8/1093)

BACKGROUND: Cyclosporin (CsA) has played an important role in the improvement of solid-organ transplant patients and graft survival. However, nephrotoxicity due to CsA remains an important clinical challenge. The renal toxicity of CsA is attributed to reduced renal blood flow which leads to hypoxia reoxygenation injury accompanied by excessive generation of oxygen-derived free radicals (ODFR). N-acetyl-L-cysteine (NAC) is a highly potent antioxidant that has been shown to reduce ODFR injury. In this study an attempt was made to assess the effect of NAC on CsA-induced lipid peroxidation and nephrotoxicity. METHODS: Adult Sprague-Dawley rats were treated orally with CsA (25 and 50 mg/kg) alone and in combination with different doses of NAC (10, 20 and 40 mg/kg) for a period of 3 weeks. Twenty-four hours after the last treatment, animals were sacrificed and blood was analysed for blood urea nitrogen (BUN) and serum creatinine (SCr), and kidney samples were analysed for lipid hydroperoxides, conjugated dienes and glutathione, and histopathological changes. RESULTS: Treatment of rats with CsA produced a significant increase in BUN and SCr level and histological abnormalities. CsA-induced impairment of renal toxicity was accompanied by significant increase in renal oxidative stress. NAC treatment significantly protected animals against CsA-induced structural and functional impairment of kidney. CONCLUSIONS: CsA-induced nephrotoxicity was significantly attenuated by NAC. This study clearly suggests the role of oxidative stress in the pathogenesis of CsA-induced nephrotoxicity. Concomitant use of antioxidants such as NAC to minimize CsA-induced nephrotoxicity in humans warrant further studies.  (+info)

TY - JOUR. T1 - Valganciclovir for cytomegalovirus prevention in solid organ transplant patients. T2 - An evidence-based reassessment of safety and efficacy. AU - Kalil, Andre C.. AU - Freifeld, Alison G.. AU - Lyden, Elizabeth R.. AU - Stoner, Julie A.. PY - 2009/5/13. Y1 - 2009/5/13. N2 - Background: Several anti-viral drugs have demonstrated efficacy in preventing Cytomegalovirus (CMV) infections in solid organ transplant (SOT) patients. The recently approved valganciclovir is the most commonly used and most expensive drug for CMV prevention. The safety and efficacy data have been drawn from a single trial. We hypothesized that valganciclovir may not be as safe as nor more effective than other therapies for CMV prevention. Methods: All experimental and analytical studies that compared valganciclovir with other therapies for prevention of CMV infection after SOT were selected. Based on meta-analytic and multivariate regression methodologies we critically analyzed all available evidence. ...
TY - JOUR. T1 - Oral Vancomycin Monotherapy Versus Combination Therapy in Solid Organ Transplant Recipients With Uncomplicated Clostridium difficile Infection. T2 - A Retrospective Cohort Study. AU - Korayem, G. B.. AU - Eljaaly, K.. AU - Matthias, K. R.. AU - Zangeneh, T. T.. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Introduction: Solid organ transplant (SOT) recipients are at high risk of Clostridium difficile infection (CDI) and CDI recurrence due to their suppressed immune systems and antibiotic exposure. A combination of metronidazole and oral vancomycin is often prescribed for SOT recipients with uncomplicated CDI despite any clinical practice guidelines supporting the need for combination therapy. This study aims to compare the CDI recurrence rates of metronidazole/vancomycin combination therapy to oral vancomycin monotherapy in SOT recipients after a first episode of uncomplicated CDI. Methods: A single-center retrospective cohort study evaluated SOT recipients diagnosed with uncomplicated CDI ...
TY - JOUR. T1 - A 20-year experience with nocardiosis in solid organ transplant (SOT) recipients in the Southwestern United States. T2 - A single-center study. AU - Majeed, Aneela. AU - Beatty, Norman. AU - Iftikhar, Ahmad. AU - Mushtaq, Adeela. AU - Fisher, Julia. AU - Gaynor, Pryce. AU - Kim, Jeeyong C.. AU - Marquez, Jose L.. AU - Mora, Francisco E.. AU - Georgescu, Anca. AU - Zangeneh, Tirdad T. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Background: Nocardiosis is a life-threatening opportunistic infection. Solid organ transplant (SOT) recipients are at higher risk (incidence 0.04%-3.5%) of developing nocardiosis. Rate of nocardiosis in the Southwestern US may be high due to environmental factors. Methods: We performed a retrospective review study on 54 SOT patients diagnosed with Nocardia between 1997 and 2016 at our center. To explore the association of various risk factors with both the development of disseminated disease and mortality, a series of Fishers exact tests was used. Findings: ...
Rejection and infection are primary causes of morbidity and mortality in solid organ transplant recipients. Current clinical practice relies on immunosuppressive drug levels measured in plasma to reflect the peripheral immune response in solid organ transplant recipients. Direct measurement of the number and functions of the immune cells themselves using multi-parameter flow cytometry may enable individualized immunosuppression management for organ transplant recipients. Multi-parameter flow cytometry will be used to compare levels and functional capabilities of multiple lymphocyte subsets between cohorts of patients receiving depletion induction and those receiving a non-depletion regimen. The activation state, cytotoxic potential and the functional capabilities of these cells will be examined within patients over the first six months post transplant ...
New-onset diabetes mellitus after transplantation (NODAT) is a complication following solid organ transplantation (SOT) and may be related to immune or inflammatory responses. We investigated whether single nucleotide polymorphisms (SNPs) within 158 immune- or inflammation-related genes contribute to NODAT in SOT recipients. The association between 263 SNPs and NODAT was investigated in a discovery sample of SOT recipients from the Swiss Transplant Cohort Study (STCS, n1 = 696). Positive results were tested in a first STCS replication sample (n2 = 489) and SNPs remaining significant after multiple test corrections were tested in a second SOT replication sample (n3 = 156). Associations with diabetic traits were further tested in several large general population-based samples (n > 480 000). Only SP110 rs2114592C>T remained associated with NODAT in the STCS replication sample. Carriers of rs2114592-TT had 9.9 times (95% confidence interval [CI]: 3.22-30.5, P = .00006) higher risk for NODAT in the ...
TY - JOUR. T1 - Emerging causes of morbidity and mortality in organ transplant patients. AU - Torbenson, Michael. PY - 2006/6/1. Y1 - 2006/6/1. N2 - PURPOSE OF REVIEW: As short-term allograft and patient survival has improved following solid organ transplantation, medium and long-term causes of morbidity and mortality have come to the forefront of patient care. RECENT FINDINGS: The metabolic syndrome has relatively recently been defined and is now being applied to studies of posttransplant morbidity and mortality. The metabolic syndrome, and its individual risk factors such as obesity and diabetes mellitus, are highly prevalent in all solid organ transplant populations and negatively impact allograft and patient survival. Even when the metabolic syndrome is not present prior to transplantation, weight gain and the metabolic syndrome can develop following transplantation with negative outcomes. A second growing concern following transplantation is the development of late malignancies. The ...
TY - JOUR. T1 - Viral infections in pediatric solid organ transplantation recipients and the impact of molecular diagnostic testing. AU - Madan, Rebecca Pellett. AU - Herold, Betsy C.. PY - 2010/6/1. Y1 - 2010/6/1. N2 - PURPOSE OF REVIEW: The review highlights advances in the diagnosis and treatment of viral infections in organ transplant recipients, with emphasis on the most significant pathogens for liver transplant recipients. RECENT FINDINGS: The development of molecular diagnostics has markedly improved the ability to rapidly identify infections in transplantation patients and has improved clinical care. Multiplex polymerase chain reaction (PCR) has enhanced the ability to identify respiratory viruses, permitting earlier treatment. Monitoring for cytomegalovirus and Epstein-Barr virus by PCR offers the opportunity for preemptive interventions. However, imperfect negative predictive values may result in failure to treat early disease, and poor positive predictive values may lead to increased ...
OBJECTIVE To review the pharmacology, adverse events, drug interactions, and use of the nonprescription analgesics in solid-organ transplant recipients. STUDY SELECTION AND DATA EXTRACTION Studies evaluating nonprescription analgesics in solid-organ transplantation were considered for evaluation. English-language studies were selected for inclusion. DATA SYNTHESIS Nonprescription analgesics (aspirin, choline salicylate, magnesium salicylate, sodium salicylate, ibuprofen, ketoprofen, naproxen sodium, and acetaminophen) are the most commonly purchased over-the-counter agents in the United States. These agents, although generally considered safe, have been associated with a number of toxicities. The salicylates and nonsteroidal anti-inflammatory drugs have been associated with gastrointestinal damage, hematologic changes, liver and kidney dysfunction, and breathing difficulties. Acetaminophen has been shown to induce hematologic changes and liver and renal dysfunction. CONCLUSION A closer look at the
In a study reported in JAMA Oncology, Acuna et al found a nearly threefold increased risk of cancer mortality in solid-organ transplant recipients compared with the general population in Ontario, Canada.. Study Details. The population-based cohort study included data from 11,061 patients who underwent solid- organ transplantation in Ontario between 1991 and 2010, including 6,516 kidney, 2,606 liver, 929 heart, and 705 lung transplantations, representing 85,557 person-years of follow-up through December 2011. Recipients had a median age of 49 years, and 64% were male.. Increased Risk. Of 3,068 deaths in the cohort, 603 (20%) were cancer-related. Cancer mortality was significantly higher in transplant recipients than in the general population (standardized mortality ratio [SMR] = 2.84, 95% confidence interval [CI] = 2.61-3.07). Risk remained higher (SMR = 1.93, 95% CI = 1.75-2.13) in analysis, excluding patients with pretransplantation cancers (n = 1,124). Increased risk was observed for all types ...
Strippoli GFM, Hodson EM, Jones CA, Craig JC. Pre-emptive treatment for cytomegalovirus viraemia to prevent cytomegalovirus disease in solid organ transplant recipients. Cochrane Database of Systematic Reviews 2006, Issue 1. Art. No.: CD005133. DOI: 10.1002/14651858.CD005133.pub2. ...
Owers DS, Webster AC, Strippoli GFM, Kable K, Hodson EM. Pre-emptive treatment for cytomegalovirus viraemia to prevent cytomegalovirus disease in solid organ transplant recipients. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD005133. DOI: 10.1002/14651858.CD005133.pub3. ...
Immunoglobulins, vaccines or interferon for preventing cytomegalovirus disease in solid organ transplant recipients Edited (no change to conclusions) answers are found in the Cochrane Abstracts powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Although the standardizations of surgical procedures and improvements in intensive care treatment, patient selection, tissue matching and organ preservation have advanced the success of SOTs, PTSS remain a frequent finding in post-SOT patients, and until now only few empirical data exist about the prevalence of PTSS among patients undergoing SOTs [30, 31]. PTSS after SOT can cause compliance problems and decreases long-term survival [32]. In our study 19 (15.1%) SOT recipients displayed PTSS. This rate is consistent with previous research. For example, in an orthotopic liver transplantation study by Rothenhäusler et al. [24], 2.7% suffered from full PTSD and 16% from partial PTSD 3.8 years after transplantation. In another study by Favaro et al. [33], the estimated frequency of transplantation-related PTSS after heart transplantation was 12%. PTSD in SOT recipients may indicate a failure of the patient to come to terms with the transplant experience and Dew et al. reported that the risk of ...
View my most recent publications at PubMed. Kotton CN, Kumar D, Caliendo AM, Asberg A, Chou S, Snydman DR, Allen U, Humar A, International Consensus Guidelines on the Management of Cytomegalovirus in Solid Organ Transplantation. Transplantation. 2010;89(7):779-95. Kotton CN, Lattes R, Parasitic infections in solid organ transplant recipients. Am J Transplant. 2009;9 Suppl 4:S234-51.. Kotton CN, Hibberd PL, Travel medicine and the solid organ transplant recipient. Am J Transplant. 2009;9 Suppl 4:S273-81. Kumar D, Morris MI, Kotton CN, Fischer SA, Michaels MG, Allen U, Blumberg EA, Green M, Humar A, Ison MG, Guidance on Novel Influenza A/H1N1 in Solid Organ Transplant Recipients. Am J Transplant. 2009. Kotton CN, Elias N, Delmonico FL, Kradin RL. Case records of the Massachusetts General Hospital. Case 15-2009. A 25-year-old man with coma after cardiac arrest. N Engl J Med. 2009;360(20):2118-25.. Marconi VC, Kradin R, Marty FM, Hospenthal DR, Kotton CN. Disseminated dermatophytosis in a patient ...
Content Update. May 26, 2020. Expanding the Donor Pool in Solid Organ Transplantation: The landscape of solid organ transplantation has changed based on organ allocation and a larger number of candidates on waiting lists. Transplant centers are expanding use of nontraditional donors to aid in access to transplantation. This changes the appropriate transplant immunosuppression and post-transplant monitoring and often dictates additional medication such as antivirals. Pharmacotherapy decisions are often complicated by prolonged organ dysfunction, specifically liver and kidney. This update focuses on four different scenarios and their implications, namely the use of donors who are: (1) older; (2) donate after cardiac death; (3) living, specifically for liver donation; and (4) Hepatitis C antibody positive.. ...
BACKGROUND: Cytomegalovirus (CMV) infection is common among solid organ transplant (SOT) recipients and may cause CMV disease. To optimize the implementation of existing prevention strategies, the Management of Post-transplant Infections in Collaborating Hospitals (MATCH) program was developed. Two key performances of MATCH (diagnosing CMV infection at low viral load (VL) and before the onset of CMV disease) were assessed prior to, during and after the implementation of MATCH.. METHODS: The MATCH program included a personalized surveillance plan, prophylaxis and preemptive therapy determined by the recipients risk of CMV infection. The plan was composed through predefined algorithms and implemented through harvesting of real-time data from medical records. Risk of CMV disease was compared for recipients transplanted during and after vs prior to the implementation of MATCH. Lung and non-lung transplants were analyzed separately.. RESULTS: A total of 593, 349, 520, and 360 SOT recipients were ...
Human cytomegalovirus (HCMV) is a beta-herpesvirus able to establish a life-long persistent infection after primary infection has been cleared. Although infection is ubiquitous in the human population, persistent HCMV infection is commonly asymptomatic in healthy, immunocompetent individuals. However, HCMV causes significant disease in immunosuppressed patients and, despite effective antiviral therapies, HCMV infection is still a significant problem in congenital disease and in bone marrow transplant recipients. Additionally, HCMV has been associated with long-term diseases including the vascular diseases atherosclerosis, restenosis following angioplasty, and chronic allograft rejection following solid organ transplantation [1-4]. Recently, HCMV has been detected in human glioblastomas, and it has been suggested that HCMV exacterbates the progression of this disease [5]. Chemokines and their receptors have been identified as key mediators in chronic inflammatory processes that attend the ...
TY - JOUR. T1 - Pharmacokinetics of Basiliximab for the Prevention of Graft-versus-Host Disease in Patients Undergoing Hematopoietic Cell Transplantation with Minimal-Intensity Cyclophosphamide and Fludarabine. AU - Podichetty, Jagdeep T.. AU - Brinda, Bryan J.. AU - Nelson, Robert P.. AU - Karr, Alissa H.. AU - Prasad, Nagendra K.. AU - Quinney, Sara. AU - Foxworthy Scott, Susanna. AU - Kiel, Patrick J.. PY - 2020/1/1. Y1 - 2020/1/1. N2 - Study Objective: Basiliximab is an immunosuppressive monoclonal antibody used for rejection prevention following solid organ transplantation; the pharmacokinetics (PK) of basiliximab in this setting are known. Basiliximab may also be used for prophylaxis and treatment of graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic cell transplantation (HCT); however, the PK of basiliximab in this setting are not known. Clinical transplant providers expect variation in the volume of distribution and clearance after nonmyeloablative ...
Organ transplantation is surgery in which a diseased or damaged organ is removed from a patient and replaced with a healthy organ from an organ donor. Allmajor organs, including the heart, lungs, liver, and kidneys, can be transplanted, and the success rate ranges from 90% to 50%, depending upon the organtransplanted. In the United States alone, greater than 20,000 organ transplantations are performed annually, and approximately 2,300 of these are heart transplants. Normally, organ transplantation is a last resort. It is performedonly on patients who are in the last stages of organ failure and for whom other treatments have not been successful. Although rejection of the transplanted organ by the immune system of the recipient (immunologic rejection) is a major problem in the field of organ transplantation, an even bigger challenge is the shortage of donor organs. In 1999 in the United States, more than 55,000 individuals were awaiting donor organs, and that number increases daily.. History and ...
Medical Park Organ Transplantation Center enjoys a reputation for its investments, specialization and success stories not only within Turkey but also around the world.. Medical Park is on par with worlds foremost centers operating in the fields of organ failure and organ transplantation, in terms of advanced technology and specialization. 800 organ transplantations are being performed per year at Medical Park Hospitals Group.. As part of its mission to save more people lives, Medical Park started performing organ transplantations in 2008 and performed 68 organ transplantations within its first year. Medical Park has performed 2.331 kidney, liver and pancreas transplantations to date, 512 being in 2009, 544 in 2010, 564 in 2011 and 643 in 2012. The success rates it has achieved in these operations are equivalent to those observed in the U.S.. In 2012, the total number of kidney transplantations performed at Turkish institutions authorized by Ministry of Health was 2903. During the same year, the ...
BACKGROUND: Polygenic obesity in Solid Organ Transplant (SOT) populations is considered a risk factor for the development of metabolic abnormalities and graft survival. Few studies to date have studied the genetics of weight gain in SOT recipients. We aimed to determine whether weighted genetic risk scores (w-GRS) integrating genetic polymorphisms from GWAS studies (SNP group#1 and SNP group#2) and from Candidate Gene studies (SNP group#3) influence BMI in SOT populations and if they predict ≥10% weight gain (WG) one year after transplantation. To do so, two samples (nA = 995, nB = 156) were obtained from naturalistic studies and three w-GRS were constructed and tested for association with BMI over time. Prediction of 10% WG at one year after transplantation was assessed with models containing genetic and clinical factors ...
List of %result_count% doctors offering Cardiac transplantation medicine in St Helens. Check out patient reviews, addresses and book a visit!
Congenital or acquired states of immunosuppression, which include solid organ transplants (SOTs), are a well-known predisposing factor for cancer development in childhood. The preparative regiments for SOT, as well as anti-rejection prophylaxis and treatment, impair the immune response and limit the immune systems capacity to recognise and eliminate cancer cells and to suppress the activity of oncogenic viruses. The 20-year cumulative cancer risk of SOT recipients is estimated at more than 50%, 5-10 times that of the general population, and is one of the leading causes of mortality in this group.1. As is the case in other situations in paediatric oncology, age is a determinant that leads to scenarios differing from those in the adult population. The probability of developing cancer in individuals aged less than 25 years is up to 50 times higher. The carcinogenic risk of immunosuppression is compounded by additional risks associated with exposure to various agents and by lifestyle factors in ...
The health of all populations will benefit from a comprehensive response to diseases contributing to end-stage organ failure, from prevention to access to effective organ transplantation programmes made possible by a sufficient supply of donor organs. There is also a strong economic imperative to improve rates of transplantation and therefore organ donation: kidney transplantation is less costly to provide than dialysis, and therefore, maximizing rates of kidney transplantation would significantly reduce overall expenditure on renal replacement therapies. Kidney transplantation also results in better survival and quality of life outcomes and enables greater productivity and community participation. The perception of organ transplantation as an expensive and luxury clinical practice is invalid; rather it is cost effective, mainstream, and a cardinal feature of comprehensive health services. Beyond the unmistakable medical benefits to patients affected by end-stage organ failure, organ ...
Organ transplantation has developed at an incredibly rapid pace since its introduction in the 1950s, and it has become a life-saving procedure for patients with end-stage organ failure. In 2009, more than 20,000 hematopoietic stem cell transplantations and 27,000 solid organ transplantations were performed in the United States alone.
Illegal Human Organ Transplantation Act - Get latest news on Illegal Human Organ Transplantation Act. Read Breaking News on Illegal Human Organ Transplantation Act updated and published at Zee News
Introduction: The aim of the study is to evaluate patient and kidney allograft survivals in primary, repeat, and kidney after nonrenal organ transplantation using national data reported to United Network for Organ Sharing (UNOS).. Patients and Methods: We retrospectively studied adult patients who received kidney transplants between January 2000 and December 2014. Given the inherent instability of comparing a small subgroup with a very large subgroup, a 10% cohort of primary kidney transplants was randomly selected from UNOS database and used as a comparison group. We excluded patients who received kidney and other solid organ transplant simultaneously and patients with more than 2 organ transplants. Survival time for each patient was stratified into the following groups[mdash]group A (comparison group): recipients of primary kidney transplant (21,076 patients), group B: recipients of repeat kidney transplant (4,428 patients), and group C: recipients of kidney transplants performed after a ...
There are multiple factors that contribute to low immunization rates among pediatric transplant candidates. New tools are needed to overcome these barriers and increase immunization rates in transplant candidates.
Outcomes after solid organ transplantation continue to improve, but premature loss of life remains a major concern, with death from cerebrovascular disease and cardiovascular disease accounting for around 20% late deaths. There are multiple contributory factors including preexisting, and the posttransplant development of, cardiometabolic conditions (such as hypertension, diabetes mellitus, hyperlipidemia, and obesity). There is accumulating evidence that the regular engagement in exercise is an important factor affecting outcomes before, during, and after transplantation; yet most waitlist candidates and recipients have reduced levels of physical activity. The mechanisms whereby physical activity is associated with better outcomes and a reduction in risk factors for cardiovascular disease are incompletely understood. Attempts to increase physical activity in the transplant population, as in the general population, have had limited success. Use of concepts from Nudge theory provides an ...
Infection is the leading cause of morbidity and mortality in immunocompromised patients such as hematopoietic/solid organ transplant recipients and individuals with human immunodeficiency virus. Community respiratory virus infections are increasingly recognized as a significant threat to these patie …
TY - JOUR. T1 - Deciphering the role of eosinophils in solid organ transplantation. AU - Onyema, Oscar Okwudiri. AU - Guo, Yizhan. AU - Hata, Atsushi. AU - Kreisel, Daniel. AU - Gelman, Andrew E.. AU - Jacobsen, Elizabeth A.. AU - Krupnick, Alexander Sasha. PY - 2020/4/1. Y1 - 2020/4/1. N2 - Eosinophils are rare granulocytes that belong to the innate arm of the immune system. This cell population is traditionally defined as a destructive and cytotoxic mediator in asthma and helminth infection. Limited data in transplantation have suggested that eosinophils play a similar role in potentiating deleterious organ inflammation and immunologic rejection. Contrary to this long-held notion, recent data have uncovered the possibility that eosinophils play an alternative role in immune homeostasis, defense against a wide range of pathogens, as well as downregulation of deleterious inflammation. Specifically, translational data from small animal models of lung transplantation have demonstrated a critical ...
TY - JOUR. T1 - Transmission of hepatitis C virus with solid organ transplantation. T2 - Incidence and clinical significance. AU - Roth, D.. AU - Fernandez, J. A.. AU - Babischkin, S.. AU - DeMattos, Angelo M. AU - Buck, B. E.. AU - Quan, S.. AU - Olson, L.. AU - Burke, G. W.. AU - Nery, J. R.. AU - Esquenazi, V.. AU - Schiff, E. R.. AU - Miller, J.. PY - 1993. Y1 - 1993. UR - UR - M3 - Article. C2 - 7680166. AN - SCOPUS:0027502448. VL - 25. SP - 1476. EP - 1477. JO - Transplantation Proceedings. JF - Transplantation Proceedings. SN - 0041-1345. IS - 1 SUPPL. 1. ER - ...
Cytomegalovirus prophylaxis with antiviral agents for solid organ transplantation answers are found in the Evidence-Based Medicine Guidelines powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
TY - JOUR. T1 - Regenerative medicine as applied to solid organ transplantation. T2 - Current status and future challenges. AU - Orlando, Giuseppe. AU - Baptista, Pedro. AU - Birchall, Martin. AU - De Coppi, Paolo. AU - Farney, Alan. AU - Guimaraes-Souza, Nadia K.. AU - Opara, Emmanuel. AU - Rogers, Jeffrey. AU - Seliktar, Dror. AU - Shapira-Schweitzer, Keren. AU - Stratta, Robert J.. AU - Atala, Anthony. AU - Wood, Kathryn J.. AU - Soker, Shay. PY - 2011/3. Y1 - 2011/3. N2 - In the last two decades, regenerative medicine has shown the potential for bench-to-bedside translational research in specific clinical settings. Progress made in cell and stem cell biology, material sciences and tissue engineering enabled researchers to develop cutting-edge technology which has lead to the creation of nonmodular tissue constructs such as skin, bladders, vessels and upper airways. In all cases, autologous cells were seeded on either artificial or natural supporting scaffolds. However, such constructs were ...
Read Hepatitis C: Current Controversies and Future Potential in Solid Organ Transplantation, Current Infectious Disease Reports on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
PubMed journal article: Persistence of yellow fever vaccine-induced antibodies after solid organ transplantation. Download Prime PubMed App to iPhone, iPad, or Android
The advancing science of transplantation has led to more transplants and longer survival. As a result, primary care physicians are more involved in the care of transplant recipients. Immunosuppressive therapy has significantly decreased rates of transplant rejection but accounts for more than 50% of transplant-related deaths, often due to infections and other risks related to long-term use. Cardiovascular disease is the leading cause of non-transplant-related mortality. Aggressive risk factor management is recommended for transplant recipients, including a blood pressure goal of less than 130/80 mm Hg and statin therapy in kidney, liver, and heart recipients. Fertility typically increases posttransplant, and female transplant recipients should avoid pregnancy for one year after surgery. The best contraceptive choice is usually an intrauterine device. Because of the increased risk of infection, patients should be tested for graft dysfunction or infection if suspicion arises. Testing should be coordinated
Organ transplantation is one of the best therapeutic options for patients with end-stage organ failure. Experimental organ transplantation is an important link between basic science and clinical practice. Both editors, Dr. Chen and Dr. Qian, have been working in this area for more than 20 years. Experts from the United States, Canada, China, Japan, Italy, Spain, Turkey, Switzerland, Hungary, and Brazil contributed 25 chapters in this book, and provided detailed descriptions of techniques for vascularized organ allografts in mice, rats, pigs, and nonhuman primates, as well as detailed descriptions of non-vascularized pancreatic islet and spleen allografts.. Furthermore, they discussed new advances in transplantation immunology. This book provides numerous important references which were carefully selected by the authors to extend their visions and knowledge. The appropriate readers of this book include medical students, graduate students, residents, surgeons, physicians and immunologists ...
Vaccine preventable infections are a recognized and potentially serious complication following solid organ transplant. Compared to healthy children, infections in organ transplant recipients are more likely to be complicated and even life threatening. However, the true incidence, morbidity, mortality, and costs resulting from hospitalizations for vaccine preventable illnesses in the pediatric liver transplant population remain unknown. The objectives of this study were to examine in liver transplant recipients at centers participating in the Pediatric Health Information System (PHIS) dataset ...
The American Society of Transplantation is dedicated to advancing the field of transplantation and improving patient care by promoting research, education, advocacy, organ donation, and service to the community.. ...
AFP February 1, 2016 - 50% of transplant-related deaths are due to immunosuppressive drugs, mostly infections - Most immunosuppressive drugs are metabolized via cytochrome P450 3A4 - so lots of interactions - Transplant recipients have increased risk of CAD and cardiovascular death HTN - goal (expert recommendation) is less than 130/80 mmHg - CCB reduce…
Journal of Osteoporosis is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working on the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases. The journal publishes research articles, review articles, as well as clinical studies related to the biology, physiology, and pathology of bone and muscle.
Describe clinical and epidemiological differences and risk factors for death among Bloodstream Infections (BSI) caused by Gram Negative (GN) and Gram Positive (GP) bacteria in the setting of solid organ transplantation. We performed a retrospective analysis of medical records, which were evaluated patients undergoing solid organ transplantation with BSI in the period from January 2000 to January 31, 2006 at Hospital São Paulo and Hospital do Rim e Hipertensão (Universidade Federal de São Paulo, Brazil). It was also performed the analysis of risk factors for death. 195 patients were included in this study with a mean age of 43.3 (± 0.90) years, 114 (58.5 %) were male and, 81 (41.5 %) were female. 168 (86.2 %) were kidney transplants, 16 (8.2 %) kidney-pancreas, 5 (2.6 %) heart, 5 (2.6 %) liver and 1 (0.5 %) liver-kidney. The mean hospital stay was 34.2 (± 62.7) days. GN accounted for 147 (75.4 %) of the BSI episodes, whereas 48 (24.6 %) were caused by GP. In the group with BSI by GN the most common
There is increasing literature on immunologic monitoring for cytomegalovirus (CMV) post-transplant in order to guide antiviral therapy. Assays used for immune monitoring include the Quantiferon-CMV, ELISpot, and flow cytometry-based quantitation of CMV-specific T-cells. In this study, 134 SOT patients had immunologic monitoring by flow cytometry as well as CMV viral loads. At 1 year after transplant, the majority of patients (89%) had CMV-specific immunity. The presence of both CD4+ and CD8+ T cell immunity correlated with the ability to control CMV viremia. This study shows the importance of measurement of CMV-specific immunity although much work needs to be done to standardize immune function assays before they can be used clinically.. ...
TY - JOUR. T1 - Cyclosporine induces cancer progression by a cell-autonomous mechanism. AU - Hojo, Minoru. AU - Morimoto, Takashi. AU - Maluccio, Mary. AU - Asano, Tomohiko. AU - Morimoto, Kengo. AU - Lagman, Milagros. AU - Shimbo, Toshikazu. AU - Suthanthiran, Manikkam. PY - 1999/2/11. Y1 - 1999/2/11. N2 - Malignancy is a common and dreaded complication following organ transplantation. The high incidence of neoplasm and its aggressive progression, which are associated with immunosuppressive therapy, are thought to be due to the resulting impairment of the organ recipients immune- surveillance system. Here we report a mechanism for the heightened malignancy that is independent of host immunity. We show that cyclosporine (cyclosporin A), an immunosuppressant that has had a major impact on improving patient outcome following organ transplantation, induces phenotypic changes, including invasiveness of non-transformed cells, by a cell-autonomous mechanism. Our studies show that cyclosporine ...
The Division of Transplantation (DoT) is within the Department of Health and Human Services, Health Resources and Services Administrations Healthcare Systems Bureau (HSB). DoT is the primary federal entity responsible for oversight of the organ and blood stem cell transplant systems in the U.S. and for initiatives to increase the level of organ donation in this country. HSBs Organ Donation and Transplantation programs extend and enhance the lives of individuals with end-stage organ failure for whom an organ transplant is the most appropriate therapeutic treatment. Key elements of the program include the Organ Procurement and Transplantation Network (OPTN), the national system that allocates and distributes donor organs to individuals waiting for an organ transplant; the Scientific Registry of Transplant Recipients (SRTR), a national database of statistics related to solid organ transplantation -- kidney, liver, pancreas, intestine, heart, and lung; and efforts to increase the supply of donor ...
Legislation tackles disability-based discrimination of organ transplant recipients WASHINGTON, D.C. - U.S. Representatives Jaime Herrera Beutler (WA-03) and Katie Porter (CA-45) today reintroduced the Charlotte Woodward Organ Transplant Discrimination Prevention Act, which will prohibit using an individuals mental or physical disability as the sole basis of determining their eligibility for an organ transplant.. The bill, named after Charlotte Woodward, an advocate fighting against discrimination who has Down syndrome and received a heart transplant in 2012, clarifies that doctors, hospitals, transplant centers and other health care providers are prohibited from denying access to organ transplants solely based on a qualified individuals disability.. If an individual needs access to a life-saving organ transplant, they shouldnt be denied based on their disability - either physical or mental, Herrera Beutler said. Im proud to reintroduce this important legislation today named after ...
OBJECTIVES: The primary objective of the study is to assess the safety of a single intravenous infusion of Mesenchymal Stromal Cells (MSCs) in patients with Acute Respiratory Distress Syndrome (ARDS) due to COVID-19. Secondary objectives are to determine the effects of MSCs on important clinical outcomes, as described below. TRIAL DESIGN: REALIST COVID 19 is a randomised, placebo-controlled, triple blinded trial. PARTICIPANTS: The study will be conducted in Intensive Care Units in hospitals across the United Kingdom. Patients with moderate to severe ARDS as defined by the Berlin definition, receiving invasive mechanical ventilation and with a diagnosis of COVID-19 based on clinical diagnosis or PCR test will be eligible. Patients will be excluded for the following reasons: more than 72 hours from the onset of ARDS; age , 16 years; patient known to be pregnant; major trauma in previous 5 days; presence of any active malignancy (other than non-melanoma skin cancer); WHO Class III or IV pulmonary ...
TY - JOUR. T1 - Single donor-derived strongyloidiasis in three solid organ transplant recipients. T2 - Case series and review of the literature. AU - Le, M.. AU - Ravin, K.. AU - Hasan, A.. AU - Clauss, H.. AU - Muchant, D. G.. AU - Pasko, J. K.. AU - Cipollina, G.. AU - Abanyie, F.. AU - Montgomery, S. P.. AU - Loy, M.. AU - Ahmed, M.. AU - Mathur, M.. AU - Chokkalingam Mani, B.. AU - Mehr, J.. AU - Kotru, A.. AU - Varma, C.. AU - Maksimak, M.. AU - Schultz, M.. AU - Obradovic, G.. AU - Alvarez, R.. AU - Toyoda, Y.. AU - Birkenbach, M.. AU - Brunner, E.. AU - Nelson, J.. PY - 2014/5. Y1 - 2014/5. N2 - Donor-derived Strongyloides stercoralis infections in transplant recipients are a rare but recognized complication. In this case series, we report donor-derived allograft transmission of Strongyloides in three solid organ transplant recipients. Following detection of infection in heart and kidney-pancreas recipients at two different transplant centers, a third recipient from the same donor was ...
TY - JOUR. T1 - Histoplasmosis in solid organ transplant recipients at a large Midwestern university transplant center. AU - Freifeld, Alison Gail. AU - Iwen, Peter Charles. AU - Lesiak, B. L.. AU - Gilroy, R. K.. AU - Stevens, R. B.. AU - Kalil, Andre C. PY - 2005/9/1. Y1 - 2005/9/1. N2 - Histoplasma capsulatum sporadically causes severe infections in solid organ transplant (SOT) patients in the Midwest, but it has been an unusual infection among those patients followed at the University of Nebraska Medical Center (UNMC), located at the western edge of the histo belt. Nine SOT patients with histoplasmosis are described (6 renal or renal-pancreas and 3 liver recipients) who developed severe histoplasmosis over a recent 2.5-year period at UNMC. Symptoms started a median of 11 months (range, 1.2-90 months) after organ transplant and consisted primarily of fever, cough, shortness of breath, and malaise or fatigue present for approximately 30 days prior to medical evaluation. All patients had an ...
TY - JOUR. T1 - Longitudinal stability of medication adherence among adolescent solid organ transplant recipients. AU - Loiselle, Kristin A.. AU - Gutierrez-Colina, Ana M.. AU - Eaton, Cyd K.. AU - Simons, Laura E.. AU - Devine, Katie A.. AU - Mee, Laura L.. AU - Blount, Ronald L.. N1 - Publisher Copyright: © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.. PY - 2015/6/1. Y1 - 2015/6/1. N2 - Solid organ transplantation requires ongoing adherence to immunosuppressants and other medications. Although adolescence is a risk factor for poor medication-taking, little is known about the patterns of adherence within individuals over time. This study aimed to examine the stability of adherence over time using three different assessment techniques. Sixty-six AYA transplant recipients and/or their caregiver completed interviews of adherence at baseline and at least one yr later. Serum immunosuppressant assay levels were collected via medical chart review. Non-adherence percentages based on ...
Post-transplantation lymphoproliferative disorders (PTLD) are a group of heterogeneous diseases that occur after organ transplantation. Determination of the origin of the tumor cells not only provides clues to its possible pathogenetic mechanism, but also gives prognostic guidance in the clinical management of patients. We reviewed the clinicopathological features of four cases of PTLD that developed after solid organ transplantation. Using microsatellite analysis performed on paraffin-embedded tissue and using multiple, highly polymorphic markers, we have successfully determined the recipient/donor origin of the tumor cells in all of them. The time of onset of the PTLD ranged from 5 to 11 mo. All cases were diffuse large cell lymphomas of B-cell lineage, and the two cases that have been tested for EBV by in situ hybridization were positive. Three of the 4 PTLD were of donor origin and these three patients died of diseases unrelated to PTLD. The single patient with PTLD of recipient origin died ...
The rate of transfusion-transmitted hepatitis E virus (HEV) in transplant recipients is unknown. We identified 60 HEV-positive solid organ transplant patients and retrospectively assessed their blood transfusions for HEV. Seven of 60 patients received transfusions; 3 received HEV-positive blood products. Transfusion is not the major route of infection in this population.
Post-transplant lymphoproliferative disorder (PTLD) is a heterogeneous group of lymphoid neoplasms associated with immunosuppression following solid organ transplantation or allogeneic hematopoietic stem cell transplantation. Mismatch...
The antibiotics and immunosuppressive drugs required by organ transplant patients can cause deafness, said Dr. Brian J. McKinnon, otologist and neurotologist at the Medical College of Georgia at Georgia Health Sciences University.. Dr. Brian J. McKinnon, otologist and neurotologist (right), and Dr. Kenneth C. Iverson, Chief Resident in otolaryngology, at the Medical College of Georgia at Georgia Health Sciences University. Antibiotics can destroy the finite number of dark cells in the inner ear. These cells produce the minute amount of fluid needed to help convert sound waves to neural impulses the brain can interpret. Apparently these dark cells are very metabolically active and antibiotics are designed to interfere with bacterias metabolic activity.. When you destroy the ability to make fluid, the system no longer functions, McKinnon said. Any sound patients may hear is incomprehensible.. Drugs that keep the immune system from attacking a transplanted organ can also leave the inner ear ...
TY - JOUR. T1 - Successful treatment of posttransplant lymphoproliferative disease with prolonged rituximab treatment in intestinal transplant recipients. AU - Berney, Thierry. AU - Delis, Spiros. AU - Kato, Tomoaki. AU - Nishida, Seigo. AU - Mittal, Naveen K.. AU - Madariaga, Juan. AU - Levi, David. AU - Nery, Jose R.. AU - Cirocco, Robert E.. AU - Gelman, Barry. AU - Ruiz, Philip. AU - Tzakis, Andreas G.. PY - 2002/10/15. Y1 - 2002/10/15. N2 - Background. Posttransplant Epstein-Barr virus-associated B-cell lymphoproliferative disease (PTLD) has a higher incidence after intestinal transplantation than after transplantation of other solid organs and is associated with a high mortality. A new anti-CD20 monoclonal antibody, rituximab, has shown efficiency in the treatment of B-cell lymphoma, including PTLD, but its use has not yet been reported in intestinal transplant recipients. Methods. We retrospectively reviewed five patients who were diagnosed with PTLD from March 1999 to August 2001, after ...
Toxoplasmosis is a relatively uncommon infectious complication after transplant. Seropositive heart transplant recipients or heart transplant recipients who receive toxoplasmosis seropositive hearts generally receive lifelong prophylaxis. A review of SOTs done in Spain identified 22 cases of toxoplasmosis. Although the majority of these were heart transplant recipients, kidney and liver transplant patients also developed the disease. Most of this was primary infection rather than reactivation. Being seronegative for toxoplasmosis prior to transplant was an independent risk factor for developing toxoplasmosis. This study provides new insights about toxoplasmosis in organ transplant recipients.. ...
Toxoplasmosis is a well-known opportunistic pathogen among AIDS and immunocompromised patients including solid organ transplant recipients. It can be presented as a life threatening disease with high morbidity and mortality among these patients. Immunosuppressive treatments could reactivate latent tissue cysts and turning solid organ transplant recipients into active toxoplasmosis (11-15).. Toxoplasmosis has also been recognized as a potential donor-to-host transmission infection after solid organ transplantation mainly from seropositive heart transplant donors to seronegative recipients, as the myocardium is one of the sites were cysts of toxoplasma gondii are located (16-18).. Toxoplasmosis transmitted from the seropositive donor to seronegative recipients has also been described after liver and renal transplantation. However compare to heart transplant patients, it is much more infrequent (16). It has been reported in 57% of heart recipients, 20% of liver recipients and less than 1% in kidney ...
[159 Pages Report] Check for Discount on Global Solid Organ Transplant Immunosuppressant Industry 2016 Market Research Report report by QYResearch Group. The Global Solid Organ Transplant Immunosuppressant Industry 2016 Market Research...
Cytomegalovirus (CMV) is a globally widespread virus that becomes latent following primary infection but reactivates frequently and, in the setting of immunocompromise, causes disease in solid organ transplant patients, including kidney transplant re
Background: The risk of acquiring Pneumocystis jirovecii pneumonia (PCP) as an opportunistic infection is well described in HIV, haematological and solid organ transplant patients with clear published guidelines for antibiotic prophylaxis. Outside these groups there is no agreed guidance for patients on immunosuppressive drugs. In non-HIV patients, manifestation is acute and severe with high mortality (35-50% with and up to 100% without treatment). With widening use of these agents physicians need to be aware of the potentially serious risks. Objectives: To quantify the perception of PCP risk and use of prophylaxis amongst clinicians who regularly prescribe immunosuppressant treatment. Methods: An online questionnaire sampling respiratory, gastroenterology and rheumatology consultants in the Mersey Deanery, England. Results: 42/104 consultants replied (21/42 Respiratory, 9/42 Gastroenterology and 11/42 Rheumatology), with 37/42 regularly starting patients on immunosuppressive agents for greater ...
TY - JOUR. T1 - Synergism between mTOR pathway and ultraviolet radiation in the pathogenesis of squamous cell carcinoma and its implication for solid-organ transplant recipients. AU - Balagula, Yevgeniy. AU - Kang, Sewon. AU - Patel, Manisha J.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Summary: Nonmelanoma skin cancers (NMSCs) are the most common malignancies in the United States in immunocompetent patients. Among the solid-organ transplant recipients, NMSCs represent a significant disease burden, and they tend to be multiple and more aggressive. While the precise mechanisms responsible for the higher risk of developing cutaneous squamous cell carcinomas (SCCs) have not been completely elucidated, ultraviolet (UV) light has been established to be critical in initiation and promotion of tumor development. More recently, significant emphasis has been placed on the role of the mammalian target of rapamycin (mTOR) pathway in SCC pathogenesis. Furthermore, some studies have demonstrated the ability of mTOR ...
Overall, annual payments by patients for tacrolimus and mycophenolic acid decreased from 2008 to 2013 for kidney, liver, and heart transplant recipients, and for the Medicare Part D program. These trends are largely explained by substitution of generic immunosuppressive medications after the introduction of generic products in 2008 and 2009. Across organs, the percentage of prescription drug events for generic tacrolimus increased from 10% to 11% in 2009 to 76% to 80% in 2013; generic mycophenolate mofetil increased from 28% to 30% of prescription drug events in 2009 to 68% to 77% in 2013 (7). This led to a substantial reduction in the overall financial burden of immunosuppressive medications to organ transplant recipients and Medicare Part D. The cost savings to Medicare result from decreases in per-patient Part D plan payments and per-patient Part D low-income subsidy program payments.. This is the first study to document the cost savings to organ transplant recipients and the Medicare program ...
Submitted by Aspergillus Administrator on 5 May 2020. Each moth we choose a handful of papers that stood out to us as highlights. Let us know if you think a particular piece of research should feature!.. Deep cutaneous fungal infections in solid-organ transplant recipients (Galezowski et al., 2020) This retrospective, observational, multicentre study was conducted in France to determine deep cutaneous fungal infections (DCFIs) diagnostic characteristics and outcomes with treatments in adult solid-organ transplant recipients. It describes the diversity and occurrence frequency of DCFIs. Phaeohyphomycoses were the most frequent DCFIs, representing a prevalence of 46%. Aspergillus species represented 8.7%.. Prevalence of fungal infection in nasal polyposis - A cross-sectional study, conducted at a tertiary care hospital in Karachi (Qaisar Sajjad et al., 2020) This cross sectional study, carried out from October 2010 to January 2015 on 221 patients in a tertiary care centre in Karachi was undertaken ...
Post-transplant lymphoproliferative disease (PTLD) is a major complication of solid organ transplantation. PTLD occurs in 2-15% of pediatric solid organ transplant (SOT) patients, depending on the organ transplanted and the immunosuppression used (Llaurador, 2017). The incidence of transplantation in pediatrics is steadily rising making PTLD the most common form of lymphoproliferation in childhood (Llaurador, 2017). Features of PTLD are similar to an immune system malignancy with abnormal proliferation of lymphoid lineage cells, typically B cells, in the setting of immunosuppression and often associated with EBV infection (Dharnidharka, 2017). Presentation and treatment choice covers a wide spectrum. The goal is to preserve the transplanted organ/graft while eradicating the lymphoproliferative disease. Most often the first intervention is reduction of immunosuppression (Dharnidharka, 2017) and is generally managed by the transplant team. Oncology providers become a prominent member of the ...
1 Introduction. The aim of this article is to determine the influence that the Constitution has on the law pertaining to organ transplants, with specific reference to organ procurement methods.1 Whenever the demand for a particular resource is higher than the offer, there is a risk of a black market forming to compensate for the shortage.2 This is indeed the case when it comes to transplantable human organs. The organ shortage is by no means a new problem. Academics have been looking for a solution to this global problem since 1980.3 In the light of this, the authors find it intriguing that this problem still exists around the world and more specifically, in South Africa. According to the Organ Donor Foundation,4 the number of solid organ transplants has declined yearly from 376 in 2009 to 319 in 2012.5 Furthermore, the number of South Africans awaiting an organ transplant increased from 3 500 in 20096 to 4 300 in 2013.7 It has also been claimed that there are as many as 15 000 people in need of ...
BACKGROUND. Pediatric organ transplantation offers an increasing number of seriously ill children the opportunity for a healthy life. However, there is currently a severe shortage of pediatric organs. Young children rarely die in circumstances that would make them medically acceptable sources of organs. Among the children younger than 2 years of age registered to receive transplants, an estimated 30% to 50% die before an organ becomes available.1 In April 1990, the United Network for Organ Sharing reported 320 children younger than 5 years of age waiting for kidney (99), liver (178), heart (34), or heart-lung (9) transplants. Although improved organization of the organ procurement system could partially ameliorate the problem, in all likelihood, pediatric organs will remain a scarce medical resource.2. Anencephaly is a congenital defect in which the cranium is absent and the cerebral cortex is virtually absent. However, vital organs, such as the heart and kidneys, are often normal. About 1000 to ...
Ethical issues in kidney transplantation – reflections from Nigeria Joseph Olusesan Fadare1, Babatunde L Salako21Department of Medicine, Kogi State Specialist Hospital, Lokoja; 2Department of Medicine, University of Ibadan, Ibadan, NigeriaAbstract: Organ transplantation has become a life-saving procedure for many disease conditions hitherto considered incurable. Kidney transplantation, now the treatment of choice for end-stage renal disease, is the commonest solid organ transplantation carried out in the world at the moment and it is the only solid organ transplantation done in Nigeria. This procedure, in addition to prolonging lives, also provides better quality of life and is evaluated as cost-effective, because it makes more resources available to other sectors of the economy. Organ transplantation in general and kidney transplantation in particular are fraught with ethical issues and dilemmas worldwide. Some of the ethical issues arising in the setting of developing countries like Nigeria may
Know the cost of Organ Transplantation in Victoria. HEALGURU INDIA is associated with best Organ Transplantation Hospital in Victoria and top surgeons in Victoria. Book your appointment now
ASHP CareerPharm: Pharmacy, , Cleveland, Ohio , PGY2 Solid Organ Transplant Residency at Cleveland Clinic Main Campus at Cleveland Clinic Main Campus
Successful Treatment of Cerebral Pheohyphomycosis Caused by Cladophialophora bantiana Infection in a Solid Organ Transplant Patient: A Case Report and a Review of Literature
TY - JOUR. T1 - Outcomes from pandemic influenza A H1N1 infection in recipients of solid-organ transplants. T2 - A multicentre cohort study. AU - Kumar, Deepali. AU - Michaels, Marian G.. AU - Morris, Michele I.. AU - Green, Michael. AU - Avery, Robin K.. AU - Liu, Catherine. AU - Danziger-Isakov, Lara. AU - Stosor, Valentina. AU - Estabrook, Michele. AU - Gantt, Soren. AU - Marr, Kieren A.. AU - Martin, Stanley. AU - Silveira, Fernanda P.. AU - Razonable, Raymund R.. AU - Allen, Upton D.. AU - Levi, Marilyn E.. AU - Lyon, G. Marshall. AU - Bell, Lorraine E.. AU - Huprikar, Shirish. AU - Patel, Gopi. AU - Gregg, Kevin S.. AU - Pursell, Kenneth. AU - Helmersen, Doug. AU - Julian, Kathleen G.. AU - Shiley, Kevin. AU - Bono, Bartholomew. AU - Dharnidharka, Vikas R.. AU - Alavi, Gelareh. AU - Kalpoe, Jayant S.. AU - Shoham, Shmuel. AU - Reid, Gail E.. AU - Humar, Atul. PY - 2010/8/1. Y1 - 2010/8/1. N2 - Background: There are few data on the epidemiology and outcomes of influenza infection in ...
Free Online Library: Encephalitis caused by pathogens transmitted through organ transplants, United States, 2002-2013.(Report, Author abstract) by Emerging Infectious Diseases; Health, general Disease transmission Risk factors Organ transplant recipients Health aspects Organ transplantation Complications and side effects Pathogenic microorganisms Physiological aspects Research Transplantation of organs, tissues, Transplantation of organs, tissues, etc. West Nile fever
You searched for: Exhibit Tags conceptn Remove constraint Exhibit Tags: conceptn Genre Articles Remove constraint Genre: Articles Language English Remove constraint Language: English Subject Brain Death Remove constraint Subject: Brain Death Subject Organ Transplantation Remove constraint Subject: Organ Transplantation ...
You searched for: Exhibit Tags conceptn Remove constraint Exhibit Tags: conceptn Genre Official reports Remove constraint Genre: Official reports Subject Brain Death Remove constraint Subject: Brain Death Subject Organ Transplantation Remove constraint Subject: Organ Transplantation ...
The aim of this honours class is to provide an integrated and broad view on the process of organ transplantation. Both cell and organ transplantation have a long history and are currently accepted treatment modalities and very successful life-saving clinical procedures in several diseases. Despite this success, there are still major challenges ahead. Transplantation is in the middle of clinical, scientific, ethical, economical and political discussions. Therefore an integrated and multidisciplinary approach is needed to help the field forward ...
You will be offered the possibility to embark your own research project or participate in ongoing transplantation-related research projects in Groningen or Mannheim ...
Screening for latent infection with Mycobacterium tuberculosis (LTBI) and treatment of test-positives is the cornerstone in the prevention of TB and should be performed preferably among individuals with risk for progression. Progression from LTBI to active TB is highest in recent contacts of patients with active TB. Moreover, it is considered particularly high in latently infected patients if they are also immunodeficient. Therefore, screening for evidence of LTBI is recommended for HIV-infected individuals, patients with chronic renal failure, individuals receiving immunosuppressive drug therapy following solid organ or stem cell transplantation, and patients with autoimmune diseases.1 ,2 Since by definition LTBI lacks the gold standard of bacteriological confirmation, the condition is diagnosed indirectly by detection of an immune response towards mycobacterial antigens with either the tuberculin skin test (TST) or interferon-γ release assays (IGRA) performed from whole blood. IGRA may have ...
Audience: Pharmacists and organ transplantation healthcare professionals. [Posted 05/18/2006] Spectrum Laboratory Products and FDA notified healthcare professionals of the recall of the active pharmaceutical ingredient tacrolimus, an immunosuppressive drug used to prevent rejections of transplanted solid organs such as heart or kidney, after learning that some lots of the ingredient are subpotent. Spectrums tacrolimus API has been used by pharmacies for compounding purposes. The use of sub-potent tacrolimus in compounded drugs for transplant recipients may lead to sub-therapeutic tacrolimus blood levels and an unacceptable increased risk of solid organ transplant rejection. Patients receiving tacrolimus for solid organ transplant should not stop taking their medication, but rather should check with their physician or pharmacist. This recall does not apply to tacrolimus marketed in finished dosage form as Prograf (Astellas Pharma, US) or to Prograf oral capsules that have been used for ...
Conventionally, the gold standard for acceptance of solid organ transplantation has been through pharmacological application of immunosuppressive agents. Although such agents have been remarkably successful for short-term allograft survival, long-term survival has been elusive. The downside to long-term application of immunosuppressive drugs is increased risk for infections [1], malignancy [2], and ultimately chronic rejection of the organ graft [3,4]. Thus, it has long been the goal of transplantation biologists to develop alternative methods that render the patients immune system specifically tolerant towards the allograft without requiring life-long administration of immunosuppressive drugs. Immunological tolerance through hematopoietic cell transplantation (HCT) has proven to be an effective solution to this problem both in preclinical animal models and the clinic [5,6].. The concept of immune tolerance was first developed in the mid-1940s when Ray Owen published on the observation that ...
Objectives:. * Gain an Understanding on the relationship between your Transplant and your Ski. * How to Prevent and Find Skin Cancers Early On.. * Common Skin Infections After Transplantation.. Guest Speaker….Marisha J. (Patel) Loss, M.D.. Assistant Professor / Department of Dematology. Johns Hopkins Hopital / Baltimore, Maryland. ...
Organ Transplant History - Organ transplant history began in 1954 with the first successful kidney transplant. Learn more about organ transplant history and face transplants.
In this study, the QFT was positive in 22% of KT recipients, and recipient QFT positivity was associated with clinically latent TB before KT. We showed that that the incidence of post-KT TB was 0.242 cases/100 person-years among 446 KT recipients at a median follow-up of 30.2 months and that neither recipient QFT positivity nor donor QFT positivity could predict post-KT TB development.. Consistent with previous reports [12, 13], the QFT was significantly associated with latent TB, whereas the TST showed no such association in patients with ESRD. Moreover, agreement between the QFT and TST was poor. Overall, our study demonstrated that the QFT is a better diagnostic test for latent TB than TST in KT candidates. Treatment of latent TB is recommended for solid organ transplant recipients with a positive TST or IGRA result [2-4]. However, the actual benefit of this practice is still unknown [2, 14]. IGRA yields a high rate of false positives [15], and some TB breakthrough cases developed despite ...
METHODS AND RESULTS: Here, we characterize the impact of donor age on solid-organ transplantation using a murine cardiac transplantation model. We found a compromised graft survival when older hearts were used. Shorter graft survival of older hearts was independent of organ age per se, because chimeric young or old organs repopulated with young passenger leukocytes showed comparable survival times. Transplantation of older organs triggered more potent alloimmune responses via intragraft CD11c+ dendritic cells augmenting CD4+ and CD8+ T-cell proliferation and proinflammatory cytokine production, particularly that of interleukin-17A. Of note, depletion of donor CD11c+ dendritic cells before engraftment, neutralization of interleukin-17A, or transplantation of older hearts into IL-17A(-/-) mice delayed rejection and reduced alloimmune responses to levels observed when young hearts were transplanted ...
Researchers have created and validated a risk score, called renal risk index, that can predict the risk of end-stage renal disease after liver transplant. Investigators at the University of Michigan and Arbor Research Collaborative for Health created the Renal Risk Index using national data of 43,514 liver transplant recipients. The results were published in the Journal of the American Society of Nephrology.. ESRD is one of the major public health problems among solid organ transplant recipients that is associated with death after transplant and high cost of care.. Our goal was to create a risk score based on the liver transplant recipients factors to identify those who were at a higher risk of developing post-liver transplant end-stage renal disease, said Pratima Sharma, MD, MS, lead author of the study and assistant professor of Internal Medicine in the University of Michigan Medical School.. (Researchers create tool to predict kidney failure or death after injury) The renal risk index ...
Associate Professor Barry Slobedman is head of the Cytomegalovirus (CMV) Research Group. Human CMV is a herpesvirus which infects a vast majority of the world¿s population, where it is a leading cause of opportunistic and congenital disease. Primary productive infection leads to a lifelong latent infection that is characterised by maintenance of the viral genome without infectious virus production. Periodically, the virus reactivates from latency and is shed in bodily secretions. Whilst primary and reactivated infections are usually mild or asymptomatic in healthy adults, primary infection is a major cause of serious congenital infection leading to still birth or neurological damage in children and reactivated infection is a major cause of life-threatening disease in immunosuppressed individuals, such as those with HIV AIDS and in allogeneic stem cell and solid organ transplant recipients.. The overall goal of the CMV Research Group is to define the mechanisms by which CMV causes ...
Post-transplant lymphoproliferative disorders (PTLD) comprise a spectrum of abnormal lymphoid tissue proliferation among organ transplant recipients. PTLD is associated with chronically immunosuppression and is frequently associated with Epstein-Barr virus (EBV) infected B-lymphocytes. PTLD has been reported to occur with a prevalence of 1.7-4% of LT recipients. While many cases of PTLD respond to a reduction in the level of immunosuppression, PTLD can present as an aggressive B-cell lymphoma [27-29]. PTLD frequently involves the liver allograft with allograft PTLD (accounting for approximately 44%) and carries a mortality rate of approximately 50% despite therapy [13,28]. Among recipients of LT, infection with the hepatitis C virus may represent an additional risk for the development of PTLD. This is of concern given the universal recurrence of HCV after LT. The hepatitis C virus may induce B-cell proliferation either independently or through a synergistic effect with the EBV virus. In one ...
Non-existent or lax laws on organ donation and transplantation encourage commercialism and transplant tourism, said Dr Luc Noel, in charge of transplantation at WHO. If all countries agree on a common approach, and stop commercial exploitation, then access will be more equitable and we will have fewer health tragedies.. Transplantation is increasingly seen as the best solution to end-stage organ failure. End-stage kidney disease, for instance, can only be repaired with a kidney transplant. Without it, the patient will die or require dialysis for years, which is an expensive procedure and often out of reach of poorer patients. Transplantation is the only option for some liver conditions, such as severe cirrhosis or liver cancer, and a number of serious heart conditions.. Recent estimates communicated to WHO by 98 countries show that the most sought after organ is the kidney. Sixty-six thousand kidneys were transplanted in 2005 representing a mere 10% of the estimated need. In the same year, 21 ...
Background: Solid organ transplant recipients (SOTR) are at an increased risk of colonization and infections with multi-drug resistant organisms (MDROs). Antimicrobial stewardship strategies emphasize that empiric antimicrobial therapy should be patient specific, guided by local data and the presumptive site of infection. Methods: Retrospective review of the microbiology surveillance system (Vigilanz ) comparing antimicrobial susceptibilities patterns of bacterial isolates between blood and urine cultures in SOTR at a 1550-beds hospital in Miami, Florida (01/01/2013 to 12/30/2014). Only the first positive isolate per patient was included. Antibiograms (ATB) were categorized by source (blood and urine). Proportions of bacterial susceptibilities to specific antibiotics were compared between cultures by source and with the hospital-wide pooled ATB using Chi-square or Fishers exact test accordingly. Results: 1005 unique patient isolates in SOTR were identified, 606 (60.3%) from urine, and 399 ...
Lymphoma can develop in the pulmonary parenchyma via 3 mechanisms: hematogenous spread from other organs; direct invasion from contiguous mediastinal or hilar lymph nodes that are the primary disease sites; or primary lung involvement.2 Primary pulmonary B cell lymphoma is rare, accounting for only 0.5-1% of all lung malignancies and less than 1% of non-Hodgkin lymphomas. Primary pulmonary B cell lymphoma is defined by clonal lymphoid proliferation affecting one or both lungs in patients with no detectable extrapulmonary involvement at diagnosis or during the subsequent 3 months. The majority of cases are mucosa-associated lymphoid-tissue lymphoma, which is a low-grade form of B cell lymphoma. High-grade pulmonary B cell lymphoma is much less common, accounting for only 11-19% of cases of primary pulmonary B cell lymphoma. High-grade pulmonary B cell lymphoma generally occurs in patients with immunodeficiency, such as from human immunodeficiency virus or solid-organ transplantation.1 Our patient ...
Skip to main content Skip to table of contents. Advertisement Hide. This service is more advanced with JavaScript available. Michel Gerald J. Front Matter Pages i-ix. Pages Immunobiology of Transplantation. Immunosuppressive Drugs in Solid Organ Transplantation. Heart Transplantation.. Lung Transplantation. Liver Transplantation. Pancreas Transplantation. Intestinal Transplantation. Kidney Transplantation. Hematopoietic Stem Cell Transplantation. Chelsea Maedler-Kron, Victoria A. Transplantation and Malignancy. Future Directions in Transplantation. Back Matter Pages About this book Introduction Many pathologists find the interpretation of biopsies and other surgical specimens from solid organ, stem cell and bone marrow transplants challenging.. Pathology of Transplantation provides a practical structured and logical approach to the diagnostic interpretation of the range of specimens from patients with solid organ, stem cell and bone marrow transplants, including the assessment of native and ...
Several terms are used in the literature to describe the presence of diabetes following organ transplantation. New-onset diabetes after transplantation (NODAT) is one such designation that describes individuals who develop new-onset diabetes following transplant. NODAT excludes patients with pretransplant diabetes that was undiagnosed as well as posttransplant hyperglycemia that resolves by the time of discharge (103). Another term, posttransplantation diabetes mellitus (PTDM) (103,104), describes the presence of diabetes in the posttransplant setting irrespective of the timing of diabetes onset.. Hyperglycemia is very common during the early posttransplant period, with ∼90% of kidney allograft recipients exhibiting hyperglycemia in the first few weeks following transplant (103-106). In most cases, such stress- or steroid-induced hyperglycemia resolves by the time of discharge (106,107). Although the use of immunosuppressive therapies is a major contributor to the development of PTDM, the ...
It is found to tubulin and radiographic findings include microcephaly, g-CSF. They are as these drugs is treated for solid-organ transplantation. They are receiving aminosalicylates must be given by cimetidine. Short-term use in extracorporeal circulations whenever any benefit in about 4% appearing in post-menopausal osteoporosis. It is high ciclosporin concentration which is widely distributed to albumin Its use which bind cD3. It is high ciclosporin concentration which is widely distributed to albumin. Combinations can i take tylenol while on lamisil of cMV, injectable dihydrocodeine, and other than to treat ischaemic heart Proprietary names further metabolism. An alternative physical and chemical properties of glipizide to prevent new osteoclasts inhibiting bacterial infections 416. The use in decreased protein, and endometrium respond initially achieve broad spectrum of incipient acute retinal cMV. Asian woman has renal failure has not restore fer- tility. It is poorly tolerated it does not ...
Surlas received her transplant in 1993 and was an active UNOS volunteer. She was a member of the OPTN Patient Affairs Committee for 10 years (from 1996 to 2006), and chaired the committee for five of those years. In addition, Surlas served on the OPTN Kidney Transplantation and Membership and Professional Standards committees and as a member of the review board (heart) for her region. She also was a member of the advisory committee that planned the National Donor Memorial.. In 2001, she was appointed by the U.S. Department of Health and Human Services Secretary Tommy Thompson to serve on the Advisory Committee on Organ Transplantation. Surlas was president/owner of MBA Associates Inc., in Aurora, Ill., where she also was a medical-legal nurse consultant and clinical audit review specialist, specializing in health-insurance issues involving transplants and donor cases. ...
New techniques for paediatric diagnoses such as computed tomography, ultrasound (US), and magnetic resonance (MR) imaging have opened a new window to paediatric organ systems, experts stressed at the European Congress of Radiology (ECR) in Vienna. Inter alia, modern imaging tools may help the observant radiologist to reveal signs of child abuse not evident to the clinician.. Vienna, Friday, March 9, 2007 - New techniques for paediatric diagnoses have rapidly developed over the past ten years. Computed tomography, ultrasound (US), and magnetic resonance (MR) imaging have opened a new window to paediatric organ systems. Through the use of these imaging modalities an increased understanding of the pathological processes that occur in the paediatric population has emerged, noted Associate Professor Isabella Maria Björkman-Burtscher (Division of Diagnostic Radiology, Lund University Hospital, SE) at the kick-off press conference of the European Congress of Radiology (ECR) 2007, an event held from ...
On March 18, 2021, the second scientific-practical conference on Successes and current issues of organ transplantation and donation in Ukraine took place.. The conference was attended by Minister of Health of Ukraine Maksym Stepanov, Deputy Minister of Internal Affairs of Ukraine Anton Gerashchenko, representative of the Verkhovna Rada of Ukraine Oksana Dmitrieva, Director of the Heart Institute of the Ministry of Health of Ukraine Prof. Borys Todurov, professor of anesthesiology and intensive care at the Bohomolets National Medical University Serhiy Dubrov, founder of the all-Ukrainian donation platform IDonor Iryna Zaslavets, director of the Clinical Emergency Hospital of Lviv Oleh Samchuk, vice Director of the Ukrainian Transplant Coordination Center Dmytro Koval, and many other participants who are concerned about the future of Ukrainian transplantation.. /* PhotoSwipe Plugin */ .psgal { margin: auto; padding-bottom:40px; -webkit-transition: all 0.4s ease; -moz-transition: all 0.4s ease; ...
Organ transplantation in different countries. *Organ transplantation in China. *Organ transplantation in Israel ... Corneal transplantation, also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced ... Corneal transplantation. Cornea transplant approximately one week after surgery. Multiple light reflections indicate folds in ... The corneal transplantation is performed when medicines, keratoconus conservative surgery and cross-linking cannot heal the ...
Organ transplantation in different countries. *Organ transplantation in China. *Organ transplantation in Israel ...
Organ transplantation in different countries. *Organ transplantation in China. *Organ transplantation in Israel ... The lung allocation score (LAS) is a numerical value used by the United Network for Organ Sharing (UNOS) to assign relative ... A mismatch in blood type can lead to a strong response by the immune system and subsequent rejection of the transplanted organs ... The lung allocation score takes into account various measures of a patient's health in order to direct donated organs towards ...
"Organ transplantation". Retrieved December 6, 2012. Nicol, Caitrin (Fall 2007). "Shot in the Dark". The New Atlantis. Schulman ... organ and tissue donation, the purported link between vaccines and autism, and informed consent. Articles on these issues often ...
Petechuk, David (2006). Organ transplantation. Greenwood. p. 11. ISBN 978-0-313-33542-6. kidney transplant ruth tucker. Barrett ... June 17 - The first cadaveric internal kidney transplantation is performed on Ruth Tucker, a 44-year-old woman with polycystic ...
Solid Organ Transplantation; Transition of Care. The PGY2 year further trains the pharmacist with symptoms, treatments (both ...
Organ recovery from beating heart cadavers has remained ambiguous to the public. There is a guideline for organ transplantation ... It states that organ donors must be dead before removing the organs, and removing the organs is not the cause of death. This ... "organ recovery". Many organs can be extracted, and many lives can be saved by one body. The bodies are generally those of organ ... As a result, the period of time in which the organs may be used for transplantation is extended. The heart contains pacemaker ...
... and as a source of organs for organ transplantation.[3] These comparatively smaller pigs were easier to work with than larger ... "Current Opinion in Organ Transplantation. 14 (2): 148-153. doi:10.1097/mot.0b013e3283292549. PMC 2687522. PMID 19469029.. ... "A brief history of cross-species organ transplantation". Proceedings (Baylor University. Medical Center). 25 (1): 49-57. doi: ... scientists are working on studying the possibility of utilizing pig hearts for human heart organ transplants, and work has been ...
Textbook of Organ Transplantation Set. John Wiley & Sons. pp. 245-. ISBN 978-1-118-88962-6. Wojciechowski, D; Vincenti, F ( ... Zand, Martin S. (July 2013). "Tofacitinab in Renal Transplantation". Transplantation Reviews. 27 (3): 85-89. doi:10.1016/j.trre ... Myrvang, H (26 June 2012). "Transplantation: Tofacitinib safe and effective in renal transplant recipients". Nature Reviews. ... World Journal of Transplantation. 2 (4): 51-68. doi:10.5500/WJT.v2.i4.51. PMC 3782235 . PMID 24175197. "FDA approves Xeljanz ...
It directly laid the foundation for the first successful organ transplantation in humans, specifically kidney transplantation, ... This became the foundation of tissue and organ transplantation. He and Burnet shared the 1960 Nobel Prize in Physiology or ... Medawar Medal, awarded by the British Transplant Society in recognition of significant research in organ transplantation. Peter ... Kenéz, J. (April 1975). "Medawar and organ transplantation". Orvosi Hetilap. 116 (16): 931-34. PMID 1090878. Sulek, K. (March ...
Textbook of Organ Transplantation. pp. 1533-1541. doi:10.1002/9781118873434.ch126. ISBN 9781118873434. ... Chair of Transplant Administrators for the American Society of Transplantation, 2010 Dunkmob Rookie of the Year Matt Pickens - ... Pickens, soccer ...
Immunobiology of Organ Transplantation. Boston, MA: Springer US. pp. 292-8. ISBN 978-1-4419-8999-4. Carreno BM, Collins M ( ... Arch RH, Green JM (2012). "Chapter 16: Costimulatory molecules in T-cell activation and transplantation: Section 2: The CD28 ...
Pediatric Solid Organ Transplantation. John Wiley & Sons. ISBN 9781444312737. Chrysant, Steven G.; Chrysant, George S. (2014-02 ...
"Immunology of Organ Transplantation". (in Chinese). Retrieved 31 July 2017. Children in Need: Kidney ... "From kings to keyholes: surgical innovation in organ transplantation , British Science Festival". British Science Festival. 22 ... Immunology of Organ Transplantation. Surgery. July 2014. "The Magazine of The City of London School Alumni Association Autumn ... 3D printing and machine perfusion technology in organ transplantation. Chandak directed his transplant team and acted alongside ...
West, L. J. (2011). "ABO-incompatible hearts for infant transplantation". Current Opinion in Organ Transplantation. 16 (5): 548 ... a b c ABO Incompatible Heart Transplantation in Young Infants. (2009, July 30). ABO Incompatible Heart Transplantation in Young ... a b United Network for Organ Sharing. (2013, January 31). OPTN Policy 3.7 - Allocation of Thoracic Organs. Retrieved from " ... "Gene expression profiling in organ transplantation". Int J Nephrol. 2011: 180201. doi:10.4061/2011/180201. PMC 3154482. PMID ...
Organ transplantation‎ (8 C, 40 P). *. ► Surgical organizations‎ (5 C, 15 P) ...
He chaired the Mid-Term ISG Conference of 2014 and serves as a National Faculty of the Indian Society of Organ Transplantation ... "National Faculty Details". Indian Society of Organ Transplantation. 2016. Retrieved 26 August 2016. "Awards and Accolades". ...
... (MP) is a technique used in organ transplantation as a means of preserving the organs which are to be ... Machine perfusion has been applied to renal transplantation, liver transplantation and lung transplantation. It is an ... "Preservation of Organs for Transplantation Evidence of Detrimental Effect of Rapid Cooling". European Surgical Research. 5 (5 ... Current Opinion in Organ Transplantation. 21 (3): 301-307. doi:10.1097/MOT.0000000000000316. ISSN 1087-2418. PMID 27145197. ...
Current Opinion in Organ Transplantation. 23 (2): 229-236. doi:10.1097/MOT.0000000000000507. ISSN 1087-2418. PMC 6423506. PMID ... Liver Transplantation: Early liver transplantation is ideal and helps to save lives. However, patients must remain abstinent ... Lee, Brian P.; Terrault, Norah A. (April 2018). "Early liver transplantation for severe alcoholic hepatitis: moving from ... from alcohol for 6 months prior to transplantation, but the ethics and science behind this are controversial. AST/ALT ratio ...
He specialized in organ transplantation. Fazel is a full professor at the medical school of National University of Iran (then ... and president of the Iranian Society for Organ Transplantation. He is also the founder of the Iranian Academy of Medical ... Transplantation Proceedings. 39 (4): 824-5. doi:10.1016/j.transproceed.2007.04.018. PMID 17524823. Fazel, I; Pourshams, A; ...
... meaning organ transplantation, in his 1960 monograph Experimental Transplantation of Vital Organs, for which he received his ... The ultimate aim of his research was for organ transplantations to be implemented in clinical practice on humans. In February ... His main goal was to push for the introduction into routine surgical practice of vital organ transplantation in humans, using " ... Shevchenko, Nikolay (October 26, 2017). "A dog with two heads: How a Soviet doctor pioneered organ transplantation against the ...
Textbook of Organ Transplantation Set. John Wiley & Sons. ISBN 9781118889626. Irwin, Richard S.; Rippe, James M. (2012-03-28). ...
Transplant:Donor Relation by Transplant Center (Report). Organ Procurement and Transplantation Network. Retrieved April 6, 2016 ... Asynchronous, Out-of-Sequence, Transcontinental Chain Kidney Transplantation. American Journal of Transplantation (Report). ... American Journal of Transplantation. American Journal of Transplantation. 11 (9): 1810-4. doi:10.1111/j.1600-6143.2011.03690.x ... By 2015, the NKR was the largest user of GPS tracking systems in the United States for organ shipments. Simultaneous Mutually ...
2011). Organ Transplantation: A Clinical Guide. Cambridge University Press. p. 2. Humar, Abhinav; et al. (2009). Atlas of Organ ... European Society for Organ Transplantation. 22 (12): 1132-1139. doi:10.1111/j.1432-2277.2009.00986.x. ISSN 0934-0874. PMID ... 2009). "Surgeon Yurii Voronoy (1895-1961) - a pioneer in the history of clinical transplantation: in Memoriam at the 75th ... Transplantation. Springer. p. 1. Coming into force January 1934. Black, Edwin (2001). IBM and the Holocaust. Crown / Random ...
"Negative vaccination by tolerogenic dendritic cells in organ transplantation". Current Opinion in Organ Transplantation. 15 (6 ... Important and interesting feature of tolerogenic DCs is also the migratory capacity toward secondary lymph organs, leading to T ... Ezzelarab M, Thomson AW (August 2011). "Tolerogenic dendritic cells and their role in transplantation". Seminars in Immunology ... providing migration to secondary lymphoid organs. Therefore, CD83high IL-10DCs could be promising and great candidates for ...
The freezers have attracted attention among organ banking and transplantation surgeons, as well as the food processing industry ... Current Opinion in Organ Transplantation. 22 (3): 281-286. doi:10.1097/MOT.0000000000000403. ISSN 1087-2418. PMC 5520671. PMID ... Bruinsma, Bote G.; Uygun, Korkut (June 2017). "Subzero organ preservation: the dawn of a new ice age?". ... Transplantation. 94 (5): 449. doi:10.1097/TP.0b013e3182637097. ISSN 0041-1337. PMID 22895610. Cheng, Lina; Sun, Da-Wen; Zhu, ...
ISBN 978-0-521-60834-3. Vamos, Marina (2010). "Organ transplantation and magical thinking". Australian & New Zealand Journal of ...
Organ Transplantation: Long-Term Results (1992) Solid Organ Transplant Rejection: Mechanisms, Pathology, and Diagnosis (1996) ... ISBN 978-0-8247-8225-2. Leendert C. Paul; Kim Solez (21 July 1992). Organ Transplantation: Long-Term Results. Taylor & Francis ... Catalan Society for Transplantation Gold Medal, 2017 American Society of Transplantation Fellowship, FAST designation 2020. ... ISBN 978-0-8247-8599-4. Kim Solez; Lorraine C. Racusen; Margaret E. Billingham (5 February 1996). Solid Organ Transplant ...
American Journal of Transplantation. September 2015, 15 (9): 2431-42. PMID 25943855. doi:10.1111/ajt.13288.. ... Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA. December 2011, 306 (23): 2594-605. PMC ... The role of peripheral T-cell deletion in transplantation tolerance. Philosophical Transactions of the Royal Society of London ... IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts. Cellular Physiology and Biochemistry. 2016, 38 ...
Organ transplants[edit]. Rituximab is being used off-label in the management of kidney transplant recipients. This drug may ... It is also used as induction therapy in highly sensitized patients going for kidney transplantation. The use of rituximab has ...
... organ transplantation and use of indwelling catheters). Oral candidiasis has been recognized throughout recorded history. The ...
Unlike other organs, bone marrow cells can be frozen (cryopreserved) for prolonged periods without damaging too many cells. ... Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... Biology of blood and marrow transplantation. American Society for Blood and Marrow Transplantation. 2 (1): 3-14. PMID 9078349. ... Wikimedia Commons has media related to Hematopoietic stem cell transplantation.. *Bone marrow transplant - How it is performed ...
World Health Organ. 91 (4): 277-282. doi:10.2471/BLT.12.110015. PMC 3629451. PMID 23599551.. ... These include trauma centers, burn treatment centers, advanced neonatology unit services, organ transplants, high-risk ... The anesthesiologist's role during surgery is to prevent derangement in the vital organs' (i.e. brain, heart, kidneys) ... Like internal medicine, there are many pediatric subspecialties for specific age ranges, organ systems, disease classes, and ...
Bone and some organs (such as lungs) especially lend themselves to projection radiography. It is a relatively low-cost ...
in females, for the limited gynecological palpations of internal organs when you are unable to access the vaginal vault or it ... Liver transplantation. *Portal hypertension *Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt ... organ damage, anal bruising, and foreign objects in the rectal cavity; ...
In organ transplantion[edit]. A1::DQ2 was at the forefront of histocompatibility science, A1 was the first numerical antigen HL ... "Celiac disease autoantibodies in severe autoimmune liver disease and the effect of liver transplantation". Liver Int. 28 (4): ...
Renal transplantation replaces kidney function by inserting into the body a healthier kidney from an organ donor and inducing ... immunologic tolerance of that organ with immunosuppression. At present, renal transplantation is the most effective treatment ... Many diseases affecting the kidney are systemic disorders not limited to the organ itself, and may require special treatment. ... Nephrologists may further sub-specialise in dialysis, kidney transplantation, chronic kidney disease, cancer-related kidney ...
She started with the removal of her original sex organs, the operation supervised by Dr. Magnus Hirschfeld. Lili went on to ... Fageeh, W.; Raffa, H.; Jabbad, H.; Marzouki, A. (2002). "Transplantation of the human uterus". International Journal of ... Del Priore, G.; Stega, J.; Sieunarine, K.; Ungar, L.; Smith, J. R. (2007). "Human Uterus Retrieval From a Multi-Organ Donor". ... See also: Transgender pregnancy, Uterus transplantation § Application on transgender women, and Male pregnancy § Humans ...
Hair transplantation - a cosmetic procedure practiced by many dermatologists.. *Intralesional treatment - with steroid or ... Immunodermatology testing is essential for the correct diagnosis and treatment of many diseases affecting epithelial organs ...
There have been many advances in solid organ transplantation over the years that have made these medications quite tolerable. ... 2008). "Hand Transplantation: The Innsbruck Experience". Transplantation of Composite Tissue Allografts. pp. 234-250. doi: ... Hand transplantation is a surgical procedure to transplant a hand from one human to another. The "donor" hand usually comes ... On October 26, 2016, the Director of hand transplantation at UCLA, Dr. Kodi Azari, and his team,[14] performed a hand ...
For years, the concept of harvesting stem cells and re-implanting them into one's own body to regenerate organs and tissues has ... "Autologous chondrocyte transplantation in the treatment of articular cartilage lesions of the talus". Orthopade (in German). ... or autologous chondrocyte transplantation (ACT). A review evaluating autologous chondrocyte implantation was published in 2010 ... called matrix-associated autologous chondrocyte transplantation (MACT), grows the patient's cells in a 3D matrix of resorbable ...
குருதி மாற்றீடு, உறுப்பு மாற்றீடு (Organ transplantation) போன்ற சந்தர்ப்பங்களிலும் நோய்த் தொற்றுள்ள குருதி மூலம் டெங்குத் ...
The disadvantage of liver transplantation is that approximately 10% of the subjects die from the procedure or complications ... Organ-limited amyloidosis. Heart. AANF/Isolated atrial. Brain. *Familial amyloid neuropathy. *ACys+ABri/Cerebral amyloid ... FAP can be ameliorated by liver transplantation. ...
Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation In National Cancer Institute Fact Sheet web site. ... "Fibroblast precursors in normal and irradiated mouse hematopoietic organs". Experimental Hematology 4 (5): 267-74. 1976. PMID ... PMID 17076602. Bone marrow transplantation is, as of 2009, the only established use of stem cells. ... 2015. Bone marrow transplantation is, as of 2009, the only established use of stem cells. ...
Particular organ problems (e.g. diseases involving the skin, heart, facial development and skeletal system) may be present in ... Virus-specific T-Lymphocytes (VST) therapy is used for patients who have received hematopoietic stem cell transplantation that ... They may involve various organs directly, as well as predisposing for long-term damage (e.g. by leading to amyloid deposition ... June 2008). "Stem cell transplantation for primary immunodeficiencies". Bone Marrow Transplant. 41 Suppl 2: S83-6. doi:10.1038/ ...
As this buildup continues, it interferes with the way certain cells and organs in the body function and leads to a number of ... For a long time, the most efficient approach had been to use bone marrow graft, or hematopoietic stem cell transplantation. ... The continued storage of GAGs in cells can lead to organs being affected in important ways. The thickening of the heart valves ... Because of all these reasons, bone marrow grafts or hematopoietic stem cell transplantation have seen a decrease in their ...
The importance and originality of a female's clitoris is underscored because it is seen as "a less significant organ, since ... Rodriguez said that a male's penis created the framework of the sexual organ.[11] ... of medicine in the Victorian era believed that mental and emotional disorders were related to female reproductive organs. Some ...
Organ EL, Rubin DH (1998). "Pathogenesis of reovirus gastrointestinal and hepatobiliary disease". Curr. Top. Microbiol. Immunol ... Narita M, Muder RR, Cacciarelli TV, Singh N (August 2008). "Protothecosis after liver transplantation". Liver Transpl. 14 (8), ...
exposure to cat feces, organ transplantation, blood transfusion, contaminated soil, water, grass, unwashed vegetables, ... organ transplantation, or CD4+ T-lymphocyte deficiency.[21]. ExhibitionEdit. Outbreaks of zoonoses have been traced to human ... Jorge Guerra González (2010), Infection Risk and Limitation of Fundamental Rights by Animal-To-Human Transplantations. EU, ... through body fluids and organs Other haemorrhagic fevers (Crimean-Congo haemorrhagic fever, Dengue fever, Lassa fever, Marburg ...
April 2000). "Liver transplantation in patients with homozygotic familial hypercholesterolemia previously treated by end-to- ... but at the risk of complications from any solid organ transplant (such as rejection, infections, or side-effects of the ... "Liver transplantation for homozygous familial hypercholesterolaemia". Arch. Dis. Child. 73 (5): 456-8. doi:10.1136/adc.73.5. ... "Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous ...
It has contributed to the development of liver transplantation, being the first in the world to carry out an adult to adult ... They do not cover generalist consultations, pre-existing conditions, medical emergencies, organ transplants, chronic conditions ... Olsen, Sonja K.; Brown, Robert S. (2008). "Live Donor Liver Transplantation: Current Status". Current Gastroenterology Reports ...
Vanderbilt also offers an organ transplantation center. Vanderbilt's first kidney transplant was in 1962; since then there have ... and the first triple organ transplant of heart, lungs and liver in 2000.[16] The Vanderbilt-Ingram Cancer Center is one of 42 ...
"Nephrology Dialysis Transplantation. 17 (6): 1014-1018. doi:10.1093/ndt/17.6.1014. ISSN 0931-0509. PMID 12032190.. ... This gene is involved in many facets of embryonic development and is important in the normal formation of many organs and ... The treatment of branchio-oto-renal syndrome is done per each affected area (or organ). For example, a person with hearing ...
Surgical resection, chemotherapy, radiation therapy, stenting procedures, liver transplantation[1]. Prognosis. Generally poor[5 ... Absence of direct invasion of adjacent organs. *Absence of widespread metastatic disease ... Adjuvant therapy followed by liver transplantation may have a role in treatment of certain unresectable cases.[70] ... In certain cases surgery may include a liver transplantation.[3] Even when surgery is successful 5-year survival is typically ...
"Severe SMA mice show organ impairment that cannot be rescued by therapy with the HDACi JNJ-26481585". primary. European ...
The organs known as the accessory digestive organs are the liver, gall bladder and pancreas. Other components include the mouth ... Liver transplantation. *Portal hypertension *Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt ... The stomach is a major organ of the gastrointestinal tract and digestive system. It is a consistently J-shaped organ joined to ... A major digestive organ is the stomach. Within its mucosa are millions of embedded gastric glands. Their secretions are vital ...
The hospital performs organ transplants and provides cancer therapy. The hospital was established in the year 2000 and operates ... a bone marrow transplantation unit with a focus on the treatment of thalassemia. The hospital provides hematology and bone ... The unit also operates the Mazumdar-Shaw Cancer Center, which was established in 2009 for organ-specific cancer care. In 2013, ...
For example, the vital organs will be attended to first, meaning that healthy, oxygenated blood may not feed into the hair ... Hair transplantation. *Hair washing. *No poo. References[edit]. *^ The World of Hair, A Scientific Companion by Dr. John Gray, ...
... doctors remove an organ from another person and place it in your body. Read about the common organ transplants. ... Organ Transplantation: Frequently Asked Questions (United Network for Organ Sharing) * Partnering with Your Transplant Team: ... Matching Organs (United Network for Organ Sharing) * Older Adults and People with Cancer, Diabetes, HIV/AIDS, Organ Transplants ... When you have an organ transplant, doctors remove an organ from another person and place it in your body. The organ may come ...
Summary Table for Balamuthia Outbreaks Asociated with Organ Transplantation. Year(s). Donor. Transplant Recipients. Symptomatic ... Transmission of Balamuthia infection has occurred via organ transplantation from infected donors on three documented occasions ... Summary Table for Balamuthia Outbreaks Associated with Organ Transplantation in the United States. ... Transplant centers and organ procurement organizations should be aware of the potential for Balamuthia infection in donors with ...
"Human organ and tissue transplantation". WHO. Retrieved 23 September 2010.. *^ "Draft guiding principles on human organ ... "Current Situation of Organ Donation and Transplantation in China" of the Institute of Organ Transplantation, Tongji Hospital, ... organ donation from voluntary civilian organ donors has become the only legitimate source of organ transplantations", and ... Organ transplantation in China has taken place since the 1960s, and is one of the largest organ transplant programmes in the ...
Transmission of Balamuthia mandrillaris through solid organ transplantation: utility of organ recipient serology for guide ... and none of the organ recipients became infected 1-3. However, although transmission via organ transplantation has not been ... Use of organs for transplantation from a donor with primary meningoencephalitis due to Naegleria fowleri.external icon Am J ... Organ transplantation from donors infected by Naegleria fowleri has occurred on at least five occasions in the U.S. ...
The shortage of organs is now the limiting factor in treating many patients with chronic organ failure, and has led to a major ... but there are not enough organs available to meet the demand. ... Demand for organ transplantation is increasing all over the ... Say yes to organ, tissue and cell donation!. The European Day for Organ Donation and Transplantation (EODD) aims to stimulate ... Demand for organ transplantation is increasing all over the world, but there are not enough organs available to meet the need. ...
These issues include the source and manner of organ procurement, as well as the allocation of organs within health systems. ... Transplantation of human organs and tissues, which saves many lives and restores essential functions for many otherwise ... Transplantation of human organs and tissues, which saves many lives and restores essential functions for many otherwise ... Ethics, access and safety in tissue and organ transplantation. Meeting report (2004). ...
History and Success Rate of Organ Transplantation. Although the clinical practice of organ transplantation is only a few ... Organ transplantation is surgery in which a diseased or damaged organ is removed from a patient and replaced with a healthy ... Normally, organ transplantation is a last resort. It is performedonly on patients who are in the last stages of organ failure ... People who wish to donate organs for transplantation may carry organ donor cards, or ensure their desires are know by their ...
Many people believe that palliative care would be inappropriate for patients on an organ waiting list, but in fact a palliative ... Cite this: Palliative Care in Solid Organ Transplantation - Medscape - Dec 08, 2015. ... she remains very hopeful that she will receive an organ. She expresses her strong faith as a Catholic, her belief in miracles, ...
This book offers a theoretical and practical overview of the specific ethical and legal issues in pediatric organ ... transplantation. Written by a team of leading experts, Ethical Issues in Pediatric Org ... pediatrics death determination in children minors as organ donors pediatric organ transplantation small bowel transplantation ... Written by a team of leading experts, Ethical Issues in Pediatric Organ Transplantation addresses those difficult ethical ...
How to Take Action to Stop Organ Trafficking, and more with our helpful step-by-step instructions with photos and videos. ... Learn everything you want about Organ Transplantation with the wikiHow Organ Transplantation Category. Learn about topics such ... Organ Transplantation. Learn everything you want about Organ Transplantation with the wikiHow Organ Transplantation Category. ... How to Take Action to Stop Organ Trafficking, and more with our helpful step-by-step instructions with photos and videos. ...
European Day of Organ Donation and Transplantation: Number of transplants in EU continues to rise ... Information on the European Day for Organ Donation & Transplantation (Geneva, 22 October 2011) ... Notice to organisations subject to the Union legislation on substances of human origin (blood, tissues and cells, and organs) ... Newsletter transplant - International figures on donation and transplantation - 2010 Vol.16, N°1, September 2011 ...
Cyclosporin A in cadaveric organ transplantation. Br Med J (Clin Res Ed) 1981; 282 :934 ... Cyclosporin A in cadaveric organ transplantation.. Br Med J (Clin Res Ed) 1981; 282 doi: ... thus enlarging the potential value of CyA in organ allografting. Of 34 recipients of renal allografts, 29 were currently ...
... the proceedings of the 32nd International Conference on Transplantation and Clinical Immunology, held in Lyon, France, on May ... diseases gene therapy immunosuppression kidney liver transplantation organ organ transplantation stem cell transplantation ... Transplantation and Changing Management of Organ Failure. Proceedings of the 32nd International Conference on Transplantation ... prospects for engineering in organ replacement, and whether transplantation will remain the most appropriate approach to organ ...
Organ transplantation: from laboratory to clinic Br Med J (Clin Res Ed) 1986; 292 :270 doi:10.1136/bmj.292.6515.270-b ... Organ transplantation: from laboratory to clinic. Br Med J (Clin Res Ed) 1986; 292 doi: ...
Thank you for your interest in having a presentation on the importance of organ and tissue donation at your school. View our ... In addition, a transplant recipient, living organ donor, will also attend to share their transplant story.. Due to the ... this initiatives roster of speakers are healthcare professionals from the University of Toronto Transplantation Institute which ...
... should uninfected patients be offered HCV-infected organs for transplantation? This review explores the ethical and practical ... positive organs for transplantation and consequently the potential to decrease waiting times for solid organ transplantation if ... Table 2. Summary of clinical trials in the era of Donor NAT testing and transplantation of HCV-infected organs Organ. Authors. ... Use of HCV-infected Organs in Solid Organ Transplantation. An Ethical Challenge But Plausible Option. ...
In addition to the organ pathology following organ transplantation that is described in the article, allotransplantation may be ... In addition to the organ pathology following organ transplantation that is described in the article, allotransplantation may be ... Psychosocial Aftercare After Organ Transplantation. Dtsch Arztebl Int 2010; 107(3): 38. DOI: 10.3238/arztebl.2010.0038a ... Physically severely ill patients associate their organ transplantation procedure with their hopes for health and wellbeing. For ...
Ethics of organ transplantation and Declaration of Istanbul. The existence and distribution of organ transplantation procedures ... Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, ... "Organ Nakli İstatistiki Veriler" [Statistical Organ Transplantation data] (PDF) (in Turkish). Archived from the original (PDF) ... See also: Organ procurement. In most countries there is a shortage of suitable organs for transplantation. Countries often have ...
Sharia Law and Organ Transplantation: Through the Lens of Muslim Jurists Experience of a New Kind: External Review of a ... Bioethics and Organ Transplantation in a Muslim Society. A Study in Culture, Ethnography, and Religion ... MUSE Marc Record: Download for Bioethics and Organ Transplantation in a Muslim Society ... renal transplantation in 2002. This includes features of the country called the Islamic Republic of Pakistan, the city of ...
In 2009, more than 20,000 hematopoietic stem cell transplantations and 27,000 solid organ transplantations were performed in ... and it has become a life-saving procedure for patients with end-stage organ failure. ... Organ transplantation has developed at an incredibly rapid pace since its introduction in the 1950s, ... encoded search term (Neurologic Complications of Organ Transplantation) and Neurologic Complications of Organ Transplantation ...
Solid organ transplantation of viral hepatitis C positive donor organs into viral hepatitis C negative recipients. Liapakis, ... Machine perfusion in organ transplantation: a tool for ex-vivo graft conditioning with mesenchymal stem cells?. Van Raemdonck, ... Overview of pediatric organ transplantation: current opinion and future perspectives on immunosuppression. Malik, Salma; Kassaï ... The Spanish model of organ donation for transplantation. Miranda, B.; Naya, M.T.; Cuende, N.; More ...
813/2004 vide its order dated 06.09.2004 had set up a Committee to examine the provisions of Transplantation of Human Organs ... Cadaver Organ Donation and Transplantation in India Cadaver organ transplants in India started in 1995 and so far 600 cadaver ... Transplantation. Organ and tissue transplantation can give a second chance at life to thousands of people. Learn more about ... Sale / purchase of human organs is already prohibited under Transplantation of Human Organs Act, 1994. Appropriate authorities ...
Organ transplantation is one of the best therapeutic options for patients with end-stage organ failure. Experimental organ ... Experimental Organ Transplantation. Huifang Chen, MD, PhD (Editor). Department of Surgery, Faculty of Medicine, Research Center ... Series: Organ Transplantation Research Horizons, Surgery - Procedures, Complications, and Results. BISAC: MED085070 ... Stem Cells in Tissue and Organ Transplantation. (Mathilde Soulez, Mélanie Dieudé and Marie-Josée Hébert, Notre-Dame Hospital, ...
... spread has caused international concern and transplant professionals are now warned about an emerging risk via transplantation. ... Solid Organ Transplantation and Zika Virus Risk Theoretically, Zika virus can spread through organ transplantation as there is ... Transplantation. Organ and tissue transplantation can give a second chance at life to thousands of people. Learn more about ... Tongue AbnormalitiesChicken PoxShigellosisTransplantationOrgan Donation and TransplantationZika Fever ...
The Secretary of Organ Donation and Transplantation in the Ministry of Health supervises organ donation, transplantation and ... This "Transplantation Law for Human Beings" has allowed "La Caja" to use organs for transplantation in patients with end-stage ... In 2011, "La Caja" implemented an Institutional Coordinator for Organ Transplantation with the objective to structure organ ... Organ Transplantation in Costa Rica. Matamoros, María A., MD1; Castro-Santa, Edward, MD, PhD1 ...
his annotated bibliography attempts to provide insight on the practices of organ transplantation and organ donation. Specific ... Procurement and Allocation of Solid Organs for Transplantation Organ Transplantation-The Potential Supply of Organ Donors: An ... Human Organ Transplantation: The Role of Law Increasing Organ Donation Increasing the Supply of Cadaver Organs For ... Home ] [ Up ] [ Organ Donation and Transplantation ] [ Negative Effects of Organ Transplants ]. Subsequent Pages:. [ Home ] [ ...
... cruzi transmission through solid organ transplantation, in which three organ recipients were infected. ... Chagas disease after organ transplantation--Los Angeles, California, 2006.. Centers for Disease Control and Prevention (CDC). ... T. cruzi also can be transmitted congenitally and through blood transfusion or organ transplantation. The infection is lifelong ... Although routine serologic testing of organ and blood donors is performed in areas of Latin America where Chagas disease is ...
How the Finding Could Improve Transplantation. Because patients with more donor blood cells had lower organ rejection rates, ... Study points toward new strategies for managing organ transplantation. *Download PDF Copy ... When a person receives a transplanted organ, the immune system often recognizes the new organ as foreign and destroys it. ... the results point toward new strategies for managing organ transplantation.. The intestines reservoir of blood-forming stem ...
Peter Damian Fehlner discuss vital organ transplant and brain death. ... Vital Organ Transplantation-Not Truly Dead Dr. Bryne and Fr. ... Many in support of vital organ transplantation base their ... 2000 Address of Blessed John Paul II is often quoted by those in support of obtaining vital organs for transplantation, but ... Without such certainty organ extraction cannot begin without violating the fifth commandment.. The declaration of Pope John ...
... "that has an expertise in organ procurement and transplantation" for "which is not engaged in any activity unrelated to organ ... the Organ Procurement and Transplantation Network may adopt and use such standards with respect to organs infected with human ... Organ procurement and transplantation network Text contains those laws in effect on May 26, 2019 From Title 42-THE PUBLIC ... Organ procurement and transplantation network. (a) Contract authority of Secretary; limitation; available appropriations. The ...
  • Organ transplantation in China has taken place since the 1960s, and is one of the largest organ transplant programmes in the world, peaking at over 13,000 liver and kidney transplants a year in 2004. (
  • In December 2005, China's Deputy Health Minister acknowledged that the practice of removing organs from executed prisoners for transplants was widespread. (
  • The condemned prisoners have been described as "not a proper source for organ transplants" by Vice-Health Minister Huang Jiefu, [12] and in March 2010, he announced the trial of China's first organ donation program starting after death, jointly run by the Red Cross Society and the Ministry of Health, in 10 pilot regions. (
  • Globally, pioneering experimental studies in the surgical technique of human organ transplantation were made in the early 1900s by the French surgeon Alexis Carrel , and successful transplants starting spreading worldwide after the Second World War. (
  • In the United States alone, greater than 20,000 organ transplantations are performed annually, and approximately 2,300 of these are heart transplants. (
  • By the late 1990s, more than 2,300 heart transplants were performed annuallyin the United States alone, not to mention the transplantation of other organs. (
  • Data gathered by the United Network for Organ Sharing (UNOS) from97,000 transplants performed at 742 different centers across the country compared the one year survival rates of transplant recipients from January 1988through April 1992 with survival rates from May 1992 to April 1994. (
  • [ 7 ] The New England Organ Bank (NEOB), which has been attempting to maximize the use of suitable organs from donors who suffered from opioid overdose, reported a 254% increase in organ donations from people who suffered from a drug overdose and a 300% increase in transplants using HCV-positive donors. (
  • these outnumber organ transplants by more than tenfold. (
  • Most human tissue and organ transplants are allografts. (
  • Cadaver organ transplants in India started in 1995 and so far 600 cadaver transplants of kidneys, heart and liver have been done in India, article describes the trails, tribulations and triumphs of the programme. (
  • Kidney transplantation in Costa Rica began in 1970, followed by heart transplants in 1991, and liver transplant in 1994. (
  • If African-Americans fail to donate their organs, African-Americans in need of these scarce commodities will undoubtedly be overlooked, and will have to wait longer to receive transplants. (
  • Other types of transplants may benefit from similar interventions, even for organs that don't appear to carry their own reservoirs of hematopoietic stem cells. (
  • Dr. Francis Delmonico , a Harvard transplant surgeon, estimates that 10% of all kidney transplants worldwide are performed with illegally trafficked organs. (
  • An increasing number of older people receive organ transplants for various end-stage conditions. (
  • After transplantation, aging impairs CD8 + T cell responses to reject organ transplants, although CD8 + T cells may also impair immune modulation. (
  • UNOS developed the online database system, called UNet SM , to collect, store, analyze and publish all OPTN data that pertains to the patient waiting list, organ matching, and transplants performed. (
  • There were 33,600 organ transplants last year in the USA, and 116,800 patients on waiting lists and there are around one billion pigs in the world. (
  • The Virtua Center for Organ Transplantation is the only provider of kidney transplants in South Jersey. (
  • Organ donation takes healthy organs and tissues from a donor and transplants them into a recipient. (
  • Tevosol, co-founded in 2015 by Drs. Darren Freed and Jayan Nagendran , developed the EVOSS™ Ex-Vivo Organ Support System to preserve, assess, and reclaim donor organs and completed its first human lung transplants in 2019 with results published in Nature Communications [ ]. (
  • We're eager to put this creative partnership to efficient use and boost our speed to market,' said Mills, 'and we're confident our machines can help procurement organizations deliver more donor organs to more surgeons for more lifesaving transplants. (
  • Bridge to Life was founded with the mission of improving organ transplants by licensing and developing new preservation solutions and technologies to provide the highest quality of service to organ procurement organizations and transplant centers. (
  • Tevosol, a Bridge to Life company, is developing EVOSS™ (Ex-Vivo Organ Support System), a portable and affordable warm perfusion machine to preserve, assess, and reclaim donor organs for lifesaving transplants. (
  • Organ transplants are one of the greatest achievements of modern medicine. (
  • The arrangement of this report offers an overview of the key elements in the transplantation process: tissue typing, procurement and preservation, immunosuppressants for solid organ and tissue transplants, and postoperative monitoring. (
  • In America alone almost 100,000 people are suffering while waiting for organ transplants, and more than 7,300 of these patients will die waiting. (
  • The biophotonic decontamination technique, which was initially developed to decontaminate lungs with viral infections such as hepatitis C, could help prevent transmission of diseases to organ recipients and increase the number of transplants. (
  • In the first 10 transplants we performed, the new technique eliminated hepatitis C virus from organs donated to two patients," Cypel said. (
  • 1 ] There was a gap following the first series of whole pancreas transplants due to poor graft outcomes with significant impact from poor organ preservation of the pancreas playing a major role. (
  • Since the advent of kidney transplantation in the mid-1950s as a high-risk research procedure, solid organ transplants have become an effective life-saving therapy for patients with established organ failure. (
  • About half of transplanted kidneys fail within 10 years, and patients with failed transplants of all types make up a sizable presence on the waiting list for new organs, a vexing challenge given that the number of people in need of organs far exceeds the supply, with more than 100,000 currently on the transplant waiting list. (
  • Also searched for Organ Transplants , Transplant , Organ Donation and more. (
  • According to thoracic surgeon Marcelo Cypel, who heads the service, the number of transplants could be higher if organs could be decontaminated, especially when the prospective donor has a chronic viral infection such as hepatitis C. (
  • 2001. Organ Farm: Pig to Human Transplants . (
  • No increase in cancer-specific mortality seen in men with prostate cancer who receive organ transplants. (
  • Until recently, these benefits were inaccessible for patients in need of solid organ transplants. (
  • Recent success with 'mini bone marrow transplants' using non-myeloablative conditioning in elderly patients with hematologic malignancy [ 1 ] have opened a new avenue for the application of chimerism in solid organ transplantation. (
  • While gradual recommencement of living kidney transplantation occurred from May 2020, the complexities of the ANZKX program meant kidney exchange transplants in Australia did not recommence until September 2020. (
  • and calls on the Government to prioritise organ donation and transplantation during the reform of the NHS to ensure a significant increase in the number of organ transplants. (
  • [3] Organ donation, however, has met resistance, and involuntary organ donation is illegal under Chinese law, [19] as it is against Chinese tradition and culture, which attach symbolic life affirming importance to the kidney and heart. (
  • Say yes to organ, tissue and cell donation! (
  • The European Day for Organ Donation and Transplantation (EODD) aims to stimulate dialogue and encourage European citizens to say yes to organ, tissue and cell donation. (
  • If you would like to save or improve the lives of many others even after your demise, speak to your relatives and friends about your personal choice concerning organ donation. (
  • You may also encourage them to say yes to organ donation! (
  • Spread the message in favour of organ, tissue and cell donation! (
  • Find out all about donation and transplantation in your country and talk about your choice with your family, friends and colleagues! (
  • Organ donation after death is a noble and meritorious act and is to be encouraged as an expression of generous solidarity. (
  • Organ donation is consistent with Hindu beliefs as it can help to save the life of others. (
  • The last act of giving and helping others through organ donation is both consistent with and in the spirit of Sikh teachings. (
  • Thank you for your interest in having a presentation on the importance of organ and tissue donation at your school. (
  • Precautions taken by prospective donors during travel to Zika prone areas will limit risk of Zika virus spread during organ donation. (
  • Organ donation may be carried out after detailed analysis. (
  • Organ donation from an individual who is asymptomatic, but tests positive for the presence of Zika virus in the blood should be delayed by 6 months, at the least. (
  • Organ donation from an infected and symptomatic donor should be avoided unless exceptional cases demand it. (
  • If travel to Zika prone areas cannot be avoided by individuals before organ donation, certain travel precautions need to be followed diligently. (
  • In 2011, "La Caja" implemented an Institutional Coordinator for Organ Transplantation with the objective to structure organ donation and transplantation across the country. (
  • Moreover, this latest legal modification granted permission for living unrelated donation established the role of a hospital-based transplant coordinator with transplant activities supervised by the secretary of organ donation and transplantation at the Ministry of Health. (
  • This annotated bibliography attempts to provide insight on the practices of organ transplantation and organ donation. (
  • Several factors have been cited as causes for the racial disparities in organ donation and transplantation. (
  • Factors attributed to disparities in organ donation include: lack of education, religious beliefs, distrust of the health care system, lack of communication between health care providers and minority patients, and desire of minority members to donate their organs only to members of their same ethnic classification. (
  • (7) The rate of organ donation among African-Americans has increased in recent times. (
  • Organ donation can certainly be a supreme act of generosity. (
  • The United Network for Organ Sharing (UNOS), a nonprofit organization contracted by the United States Department of Health and Human Services (HHS) to administer the nation's organ transplant program, is revising the requirements for organ donation programs in order to allow patients to be evaluated as potential organ donors before any decisions are made about the withdrawal of life sustaining measures. (
  • This brought such an outcry from disability advocates that the current revision no longer recommends singling out specific diagnoses for organ donation. (
  • In fact, UNOS states that it is unnecessary to obtain consent for organ donation from the next of kin or other health care surrogate if a patient has indicated they want to be an organ donor through something like a living will or a check in the organ donor box on their drivers license. (
  • Considering someone for organ and tissue donation at the end of life is complicated. (
  • In this course you will learn about the science behind death determination and when it is possible for deceased organ donation take place. (
  • By improving knowledge of good ethical practices, cultural and religious considerations and the logistics of the organ donation process this course will empower the interactions and discussions of medical professionals and the general public at an often confusing time. (
  • This course will help you to ensure that the option of organ donation is compassionately explored in all appropriate situations at the end of life in the best way possible. (
  • I have a better idea now about what organ donation entails and how to go about this process. (
  • You've reached the final week of the course Organ Donation: From Death to Life. (
  • Many factors influence organ donation rates across the world - from religion and culture to where you live and what resources are available. (
  • Dr Boitumelo Nkgudi a colleague of mine from Department of Surgery will speak to us on the influence that different religions and cultures have on organ donation. (
  • Organ donation comes with a lot of stigma and religious and cultural competence is essential to connecting with potential donor families before asking for consent for organ donation. (
  • We will end off our last week by looking at how to assess the true potential of deceased organ donation, what deceased organ donation models exist, and possible strategies to improve them including improving public awareness. (
  • Jennifer A. Chandler describes some of the ethical and legal challenges surrounding organ donation following medical assistance in dying. (
  • In Canada, people with neurodegenerative conditions who satisfy the legal eligibility criteria for assisted dying may also meet the medical eligibility criteria for organ donation . (
  • Live organ donation does not impede the life of the donor. (
  • In fact, religious concerns are considered by many as an important reason that explains why many individuals decline deceased and live organ donation and/or the willingness to accept a transplant. (
  • This system contains data regarding every organ donation and transplant event occurring in the United States since October 1, 1987. (
  • Organ donation and transplantation save over 28,000 lives a year. (
  • Colorado experienced a case of a live organ donation that had been arranged through a commercial internet website. (
  • ACOT believes that the implementation of these first seven recommendations will ensure the protection of potential living donors and simultaneously enhance the effectiveness of living donation and transplantation. (
  • One of its principal functions is to advise the Secretary on federal efforts to maximize the number of deceased donor organs made available for transplantation and to support the safety of living organ donation. (
  • This new strategy contains a series of recommendations which aim to enable the UK to match world-class performance in organ donation and transplantation. (
  • Gregory Rutecki, " Sharing Scarce Organs with Others: Designating Donation as a Model of Giving . (
  • Interested in more resources on organ donation & transplantation? (
  • A complete listing of open access resources from CBHD on topics related to organ donation & transplantation is available here . (
  • Ali Abdulkarim Al-Obaidli, Chairman of the National Committee for Organ Transplantation , emphasized on the importance of a strong culture of donation of organs among citizens and residents in the country and building an integrated partnership between government and private health institutions and charities to achieve its goals, in addition to the integration with the GCC countries through various aspects of cooperation. (
  • Dr Ali Abdulkarim Al Obaidli, chairman of the National Committee for Organ Transplantation , said that six cases of donation have been done in the country with the first organ harvest being from a deceased patient at Al Qasimi Hospital, where he saved five lives. (
  • While organ transplantation has become normalised in the West--particularly since the introduction of effective immuno-suppressant drugs, dramatically reducing the complications of tissue rejection--in Japan `brain-death' is not widely accepted, organ donation is unpopular and transplantation procedures rare. (
  • In this context the European Commission commissioned RAND Europe to provide support for assessing the impacts of four policy options to improve organ donation and transplantation in the European Union. (
  • Furthermore, both forms of clinical transplantation results have progressively improved, due to the ongoing refinement of organ donation and its various technical processes, combined with the evolution of immunosuppression and patient care now offering excellent long-term treatment for both type-1-diabetes and concomitant renal failure. (
  • Defining the vital condition for organ donation. (
  • The issue of organ donation and of how the donor pool can or should be increased is one with significant practical, ethical and logistic implications. (
  • The Ethics of Organ Donation by Living Donors. (
  • The article explores the ethical issues surrounding elective ventilation, the practice of allowing people with severe brain injuries and hopeless prognoses to be placed on ventilators until they are brain dead so that their organs can be harvested to improve organ donation rates in Canada. (
  • An introduction is provided to articles within the issue including "Recognized but not known: Learning from a rural organ donation experience," by T. McConnell Henry, "Living renal transplant donors' expectations of recipients' post-transplant quality of life and longevity," by Pam McGrath and. (
  • Liver transplantation is one of the most common organ donation procedures and is the only available solution for end-stage liver disease patients - thus making the difference between life and death for thousands of people. (
  • The EU is trying to address the challenges linked to organ donation and transplantation thanks to an Action Plan (2009-2015) and with the future adoption of the proposal for a Directive of the European Parliament and of the Council on standards of quality and safety of human organs intended for transplantation . (
  • 2001. 'To Solve a Deadly Shortage: Economic Incentives for Human Organ Donation. (
  • There institutions were House of Commons Standing Committee on Health and the National Coordinating Committee for Organ and Tissue Donation, Distribution, and Transplantation. (
  • As a result, in 2001, the Canadian Council for Donation and Transplantation (CCDT) was established. (
  • The principles presented in the act were reaffirmed in the reports of 2002, 2004, and 2003 accordingly by First Ministers of the state (Canada's Organ and Tissue Donation and Transplantation Communities & Canadian Blood Services, 2011, p. 52). (
  • While the organ and tissue donation and transplantation system (OTDT) is an essential part of Canada's health care system, it follows the same principles and foundations. (
  • In fact, these principles lie in the strategies of the OTDT system in order to improve and develop the current situation in the particular area (Canada's Organ and Tissue Donation and Transplantation Communities & Canadian Blood Services, 2011, p. 52). (
  • Organ donation is giving an organ to someone else who needs a transplant. (
  • This donation will greatly enhance or save the life of the person who receives the transplanted organ. (
  • Organ donation is an amazingly generous act and saves thousands of lives in the UK every year. (
  • Remember to tell your family your organ donation decision, as their support is needed for donation to go ahead. (
  • John Green, Director of Community Relations, will share his experience and reflections on attending the recent 2009 Organ Donation Conference in Berlin, Germany. (
  • Topics will include an overview of donation and transplantation around the world, what are some of the major successes and challenges being faced by organ procurement organizations and countries as they work to increase donor designations, transplant tourism, results of studies conducted that influence an individual's decision. (
  • The first successful brain-death organ donation soon followed. (
  • The need is increasing, therefore, organ donation must increase. (
  • Living kidney donation and transplantation is most often directly from a relative or close friend (directed donation), though for some patients who are eligible for a kidney transplant and have a living donor who is willing but unable to donate directly because of an incompatible blood or tissue type, it is facilitated through the Australian and New Zealand Paired Kidney Exchange (ANZKX) program. (
  • Go forward to 2020 eye and tissue donation and transplantation data . (
  • or download a PDF copy of the 2020 donation and transplantation activity report . (
  • welcomes NHS Blood and Transplant's strategic objective to increase deceased organ donation by 60 per cent. (
  • Information on Organ donation, Dialysis, the kidney disease Glomular Nephritis, and a plea for a Donor. (
  • Center for Donation and Transplantation (Albany, N.Y. (
  • Clinicians should consider Balamuthia as a cause of encephalitis in transplant recipients, particularly in those recipients who received organs from a donor who died from a neurologic or unknown cause of death. (
  • To date, among three transplant clusters, symptomatic organ recipients have received chemotherapy for treatment of transplant-transmitted granulomatous amebic encephalitis and asymptomatic organ recipients have received prophylactic chemotherapy, guided by serology, for presumed Balamuthia mandrillaris exposure. (
  • Although the serological treatment points were experimental and require further confirmation and optimal preemptive therapy regimens are undefined, asymptomatic organ recipients in these three clusters who had initial titers ≥1:64 and who were managed in this way did not develop granulomatous amebic encephalitis. (
  • Organ transplantation from donors infected by Naegleria fowleri has occurred on at least five occasions in the U.S. and none of the organ recipients became infected 1-3 . (
  • In a report from the U.S. Department of Health and Human Services in December 1997, the one-year and three-year survival rates for organ transplantation recipients had reached an all-time high. (
  • There are currently no policies or regulations governing the transplantation of HCV-positive organs into HCV-uninfected recipients. (
  • Nevertheless, diagnosis and management of perioperative complications of organ transplantation still plays a prominent role in determining the postoperative course of allograft recipients. (
  • Future developments in the field of organ transplantation, including newer immunosuppressive medications and xenograft, pluripotent stem cell and neural tissue transplantation, will further change the spectrum of neurologic and other complications in transplant recipients. (
  • Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). (
  • In the United States, one previous report documented T. cruzi transmission through solid organ transplantation, in which three organ recipients were infected. (
  • A marketplace approach would also unfairly favor those who have the means to pay as organ recipients. (
  • Decreased Treg output from the thymus may impair transplantation tolerance in aged recipients. (
  • transplantation recipients in Changsha, China, in 2016. (
  • It also widens the typical 10-hour window for a potentially successful liver transplant, giving surgeons more time to assess organs and select the most suitable recipients. (
  • Adequate levels of vitamin-D in kidney transplant recipients is associated with lower infection risk at any time post-transplantation. (
  • Transplant professionals use it to register transplant candidates on the national waiting list, match them with donated organs, and enter vital medical data on candidates, donors and transplant recipients. (
  • A growing understanding of the role of DAMPs in directing the immune response to transplantation has suggested novel avenues for the treatment or prevention of allograft rejection that complement contemporary immunosuppression and could lead to improved outcomes for solid organ recipients. (
  • The prognosis of recipients varies considerably, but there are many transplant recipients who live for decades with their new organs. (
  • However, polyclonal B-cell proliferation is often seen among organ transplantation recipients. (
  • Under this paradigm, individuals would join the organ system as both potential suppliers of cadaveric organs and potential recipients of organs. (
  • This study will investigate the clinical variables that may be used to predict who among the solid organ transplant recipients will develop cytomegalovirus (CMV) disease after completing antiviral prophylaxis. (
  • This study will investigate the clinical and laboratory variables that may be used to predict who among the solid organ transplant recipients will develop CMV disease after completing antiviral prophylaxis. (
  • Method developed by scientists in Brazil and Canada can prevent transmission of diseases to organ recipients. (
  • In 2 small case series of solid-organ transplant recipients, the potassium binders patiromer and sodium zirconium cyclosilicate appeared effective in the short term in managing hyperkalemia. (
  • The article focuses on the studies on the matching donors and recipients' age and improving the survival of kidney and patients among recipients of all ages which were presented at The Transplantation Congress in Vancouver, British Columbia in 2010. (
  • We measured yellow-fever neutralizing antibodies in 53 SOT recipients vaccinated prior to transplantation (including 29 kidney recipients and 18 liver recipients). (
  • Our data suggest there is long-term persistence of antibodies to yellow fever in SOT recipients who have been vaccinated prior to transplantation. (
  • Organ transplant recipients of all races/ethnicities are at higher risk for skin cancer, therefore routine, annual total-body skin cancer screenings should be a part of post organ transplant care. (
  • Cancer mortality in solid-organ transplant recipients (SOTRs) was increased compared with the cancer death rate expected in the general population. (
  • The recent application of the bone marrow techniques in clinical solid organ transplantation has yielded results that could fundamentally alter the role of immunosuppression in organ transplant recipients in the near future. (
  • Conventional HSCT involves the use of aggressive myeloablative conditioning that would not be acceptable in the context of organ transplantation where the recipients have severe physiologic derangement from end stage organ failure. (
  • In a new retrospective analysis, solid organ transplantation saved more than 2 million life-years, including more than 400,000 among liver transplant recipients, during a 25-year period, according to new study data published in JAMA Surgery . (
  • Offers support and comfort to recipients and their families as they experience the trials of an organ or tissue transplant and support and information to future transplant recipients on a waiting list. (
  • Transplant centers and organ procurement organizations should be aware of the potential for Balamuthia infection in donors with encephalitis of uncertain etiology. (
  • Organ donors may be living, brain dead , or dead via circulatory death. (
  • The desperate shortage of organ donors in Scotland has become an important matter of concern for the Health secretary, Nicola Sturgeon. (
  • The following considerations should be borne in mind when selecting donors for transplantation . (
  • Organ donors for pregnant women or women of childbearing age should be screened well for the presence of Zika as the disease is particularly harmful to unborn babies. (
  • Use mosquito nets while sleeping, especially for children, pregnant mothers and prospective organ donors. (
  • Progress in kidney transplantation has been supported largely by living donor procedures, initially focusing on living related donors, and later expanded to nonrelated living kidney donors. (
  • Reimbursement structures have been established to facilitate follow-up on potential donors by coordinators, contacting transplant teams, and allocating organs. (
  • Although routine serologic testing of organ and blood donors is performed in areas of Latin America where Chagas disease is endemic, no T. cruzi screening test is licensed in the United States. (
  • Normally, patients are not evaluated as possible organ donors until after a decision to remove life sustaining medical care is made. (
  • The first attempt by UNOS to revise the guidelines actually designated specific neurological diseases such as high level spinal cord injuries, muscular dystrophy, and Lou Gehrig's disease as conditions to be flagged as potential organ donors on any admission to the hospital. (
  • For higher-risk kidneys, for example from older donors, this approach was already known to offer better results than the cold storage techniques by which organs are transported in the iconic ice boxes, Ploeg notes. (
  • Organs from deceased donors are removed only after certain death has be confirmed. (
  • however, the 40% decline of available organ donors in recent years in Germany necessitates the optimization of available resources and possibly extending the criteria to older donors. (
  • The median age of donors of transplanted organs increased from 49.3 years in 2010 to 57.3 years in 2016 (p = 0.02). (
  • p = 0.005) after transplantation of organs from donors ≥80 years old. (
  • Despite conservative organ acceptance there were higher rates of retransplantation after transplantation from very old donors. (
  • Deceased donors , individuals who have designated themselves as organ donors (or their family has consented to donate the person's organs) and have passed away from natural or accidental causes. (
  • Organs such as a kidney may be donated by living donors or harvested from brain-dead organ donors. (
  • An assessment of endotoxin transfer will assist in further defining the risks associated with organ transplantation from donors with N. (
  • Miller, Truog, and Brock have recently argued that the “dead donor rule,†the requirement that donors be determined to be dead before vital organs are procured for transplantation, cannot withstand ethical scrutiny. (
  • Thus, the OTDT system controls the donated organs and tissues to be taken from the donors who authentically wish to save one's life. (
  • Organ donors are needed. (
  • In addition to the constant improvement in conservative management of organ failure in general, ongoing research in selected fields is reported in the proceedings, such as liver transplantation vs artificial liver, novel dialysis strategies vs evolving immunosuppression in kidney transplantation, islets transplantation and external implantable insulin pumps vs pancreas transplantation in diabetic patients, circulatory assistance and intramyocardial myoblast injection vs heart transplantation. (
  • Liver transplantation has positive results preliminarily, but has even less available data because viable HCV-infected donor livers are typically transplanted into HCV-infected individuals. (
  • Organ transplantation may also improve neurologic function in various disorders with neurologic manifestations such as Wilson disease (liver transplantation), familial amyloidosis with neuropathy (liver transplantation), and diabetic neuropathy (pancreas transplantation). (
  • The following presents an overview of the growth of organ transplantation , specifically liver transplantation, and the societal factors that potentially influence the moral and ethical decisions in liver transplantation policy. (
  • Takotsubo cardiomyopathy and coronary vasospasm during orthotopic liver transplantation: separate entities or common mechanism? (
  • Tako-Tsubo syndrome as a rare cause of cardiac failure in liver transplantation," Liver International , vol. 30, no. 1, pp. 159-160, 2010. (
  • Stress-induced cardiomyopathy (Takotsubo cardiomyopathy) after liver transplantation-report of two cases," Transplantation Proceedings , vol. 44, no. 8, pp. 2497-2500, 2012. (
  • EASL has contributed to the debate by meeting with Commission officials on this topic and explaining the particularities of liver transplantation. (
  • Robotic applications in kidney, pancreas, and liver transplantation have been reported. (
  • Between January 2001 and October 2003, 45 patients received living donor liver transplantation (LDLT) at five different hospitals. (
  • In 2002, doctors at Xijing Hospital of the Fourth Military Medical University described three cases of living related liver transplantation. (
  • Although the clinical practice of organ transplantation is only a few decadesold, attempts to replace a failing organ with a healthy one have occurred for centuries, and mythic literature often describes it as a cure for disease.The first successful organ transplant was a kidney transplant performed in 1954 in Boston, Massachusetts. (
  • Learn about topics such as How to Find a Kidney Donor , How to Prepare for a Kidney Transplant , How to Take Action to Stop Organ Trafficking , and more with our helpful step-by-step instructions with photos and videos. (
  • This promising strategy has been the most widely studied in kidney transplantation. (
  • [ 4 ] At the same time as this epidemic has spread, the waitlist for kidney transplantation has increased to over 100 000 people in the United States. (
  • He remarked that controversy is not new to organ transplantation, dating to the first successful transplant in 1954 of a kidney from one identical twin to another. (
  • Kidney transplantation is a lifesaving procedure for people with end-stage kidney disease. (
  • Transplantation is often used to treat end-stage kidney disease. (
  • Diabetes is the most common cause of kidney and pancreas transplantation. (
  • So, an outside physician may have a patient that has some sort of organ disease, whether it's kidney failure, liver failure, or type 1 diabetes. (
  • Reinfusion of these cells into the recipient after kidney transplantation leads to very prolonged ?80 days?and perhaps even indefinite graft survival in three long-surviving animals without administration of additional immunosuppressive agents. (
  • The biggest experience has been described in kidney transplantation. (
  • Another proven advantage is that the robotic kidney approach permits transplantation in extreme BMI categories without additional technical complications. (
  • 2010). Laparoscopic kidney transplantation. (
  • Robotically assisted donor nephrectomy for kidney transplantation. (
  • Robotic-assisted laparoscopic donor nephrectomy for kidney transplantation. (
  • However, it is also possible to donate a kidney or part of your liver as a living organ donor. (
  • A living organ donor is someone who donates a kidney, or on rare occasions a partial liver, to another person. (
  • Three different organ replacement techniques were used: liver-pancreas-duodenum en bloc (original procedure), liver only (modified procedure), and liver plus pancreatic islets. (
  • a, Original cluster procedure with transplantation of liver-pancreas-duodenum en bloc. (
  • The Global and regional markets (except the US) for Organ and Tissue Transplantation in this report are analyzed by the following Product Segments - Organ Tranplantation (Heart, Kidneys, Liver, Pancreas, Lungs, and Corneal Transplantation). (
  • For more than five decades, we have been refining advances in pancreas whole organ and islet cell transplantation as clinical therapies to treat the ever-increasing number of patients suffering from type-1-diabetes. (
  • Briefly, we cover the history of pancreas retrieval procedures, the importance of donor selection, the intricate processes of the organ donor operation, preservation of the pancreas, and the ideal ways to best improve outcomes for transplantation. (
  • Improving and providing the optimal donor and preservation conditions underpinning the success of subsequent whole pancreas or islet transplantation as a safe, effective, and feasible therapeutic option for an increasing number of patients suffering from type-1-diabetes. (
  • Since Kelly and colleagues performed the first whole pancreas transplant in 1966, significant advancements in pancreas transplantation have been made. (
  • The required period of organ culture for optimal graft function was investigated for foetal mouse pancreas of different gestational ages. (
  • A chronic shortage of organs, tissues and cells. (
  • Transplantation of human organs and tissues, which saves many lives and restores essential functions for many otherwise untreatable patients, both in developing and developed countries, has been a topic for ethical scrutiny and health care policy-making for more than thirty years. (
  • Organs and/or tissues that are transplanted within the same person's body are called autografts . (
  • A subset of allografts in which organs or tissues are transplanted from a donor to a genetically identical recipient (such as an identical twin). (
  • Analysis of circulating white blood cells in patients after intestinal transplantation suggests that the cells derived from the donated intestine have matured and been educated in the recipient to be tolerant of the recipient's own tissues. (
  • The concept of cross-species transplantation, known as xenotransplantation, is the transfer of living cells, tissues or organs from one species to another. (
  • Since the first successful organ transplant in 1954, the transplantation of organs and tissues has enabled thousands of individuals increased longevity by replacing diseased or damaged organs and tissues. (
  • Could IAFGP help improve organ transplantation by preserving donor tissues for longer periods of time? (
  • Most donated organs and tissues are from people who have died. (
  • Pursuant to Public Law 92-463, the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the fourteenth meeting of the Advisory Committee on Organ Transplantation (ACOT), Department of Health and Human Services (HHS). (
  • The Health Resources and Services Administration (HRSA) is requesting nominations to fill vacancies on the Advisory Committee on Organ Transplantation (ACOT). (
  • For many patients, the need for lifelong drug treatment, the possibility of organ failure, the damage to other organ systems as a result of immunosuppression, or the associated risk of developing cancer are not compatible with a life free from fear and anxiety and a sufficiently high quality of life. (
  • A combined multiorgan transplantation approach may offer a lower rate of allograft rejection and lower immunosuppression needs. (
  • Neurologic complications are related to the surgical procedure of transplantation, posttransplant immunosuppression, opportunistic infection, or the inherent disorders that led to transplantation. (
  • But high rejection rates and life-threatening complications from immunosuppression have limited the success of human intestinal transplantation. (
  • The actuarial survival rates stratified by transplantation procedure, immunosuppression, and tumor diagnosis and extent showed no statistically significant differences beyond the three different transplantation groups. (
  • Initial efforts to offer transplantation to HIV-infected patients raised concerns about the potential impact of immunosuppression on accelerating HIV disease progression or reactivating AIDS-related opportunistic infections (OIs) and neoplasms. (
  • It took almost 20 years for the development of newer surgical techniques including use of newly developed perfusion solutions, segmental grafts, advances in ductal drainage including bladder drainage, and effective immunosuppression regimens such that whole organ transplantation burgeoned, with great advances made by Sutherland and colleagues at the University of Minnesota [ 2 ]. (
  • As a result, approaches to induce tolerance to transplanted organs and/or minimize immunosuppression are a major priority. (
  • Although rejection of the transplanted organ by the immune system of the recipient (immunologic rejection) is a major problem in the field of organ transplantation, an even bigger challenge is the shortage of donor organs. (
  • This is particularly prominent in the field of organ transplantation. (
  • Rejection happens when your immune system attacks the new organ. (
  • One of the biggest obstacles yet to be overcome in organ transplantation is immunologic rejection, an automatic response by the immune system of the recipient that attacks and destroys the "foreign" tissue of the new organ. (
  • Non-adherence has been shown to be associated with an increased risk for acute rejection, infections, and chronic rejection of the transplanted organ ( 1 , 2 ). (
  • After a transplantation procedure, the fear of transplant rejection and failure is a stressor that can trigger anxiety related and depressive adjustment disorders after the operation. (
  • Some of the key areas for medical management are the problems of transplant rejection , during which the body has an immune response to the transplanted organ, possibly leading to transplant failure and the need to immediately remove the organ from the recipient. (
  • Due to the genetic difference between the organ and the recipient, the recipient's immune system will identify the organ as foreign and attempt to destroy it, causing transplant rejection. (
  • Because patients with more donor blood cells had lower organ rejection rates, the results point toward new strategies for managing organ transplantation. (
  • Cordyceps may reduce the need for anti-rejection drugs and improve the outcome of renal transplantation. (
  • Eventually, Dr. Church says, the company wants to engineer pigs with organs so compatible with humans that patients will not need to take anti-rejection drugs. (
  • Organ transplantation is accompanied by nonspecific immune suppression therapy to prevent T cell-mediated rejection. (
  • Once the rejection phases have passed, few patients experience problems related to their new organs. (
  • Cyclosporine remains today as the drug of choice to combat tissue rejection after transplantation. (
  • Biomarkers matter in transplantation because of the imprecision of current methods to identify both acute and chronic rejection, predict the risk of infection and patient prognosis, and manage the potent but life-saving immunosuppressant therapy required for every transplant patient. (
  • Daniel Salomon, MD, explained the long-standing challenge in identifying rejection of transplanted organs, either through invasive biopsies or imperfect blood-based markers, both of which detect problems well into the disease process. (
  • All this subclinical rejection was already predicted by the fact that you have to destroy 50 percent of the organ before you see a decline in function. (
  • That's why an early diagnostic for rejection is a pressing medical need in transplantation. (
  • Written by a team of leading experts, Ethical Issues in Pediatric Organ Transplantation addresses those difficult ethical questions concerning clinical, organizational, legal and policy issues including donor, recipient and allocation issues. (
  • [3] [4] Other ethical issues include transplantation tourism (medical tourism) and more broadly the socio-economic context in which organ procurement or transplantation may occur. (
  • Cyclosporin A in cadaveric organ transplantation. (
  • Bioflavonoid therapy with curcumin and quercetin improves cadaveric renal transplantation in humans. (
  • Given that tens of thousands of useable cadaveric organs are buried or incinerated every year, the organ shortage is a social, political and legal problem, one that is inherent in the conceptual design of the current organ system. (
  • giving the gift of life"), it is not clear that cadaveric organ donations are actually altruistic, nor is it clear why promotion of altruism should be a goal of our organ system. (
  • This essay proposes an integrated system for procuring and distributing cadaveric organs, based on the notion of a cooperative project. (
  • 1991.'The Economics and Ethics of Alternative Cadaveric Organ Procurement Policies. (
  • The Role of the Family in Cadaveric Organ Procurement. (
  • In the words of the Secretary of the Department of Health and Human Services, Donna E. Shalala, the "real answer to the problem of scarce organs is to increase the amount of organ donations. (
  • Even worse, the current system creates an injustice, violating basic principles of reciprocity, by giving scarce organs to those who have refused to contribute organs themselves. (
  • Consequently, therapy of the underlying liver disease, such as hepatitis C virus (HCV), was often not attempted, and transplantation of scarce organs was not a consideration. (
  • A heart/lung transplant at Stanford University Medical Center in 1981 achieved successful organ functioning for five years. (
  • Further, while HCV-infected heart and lung transplantation, which face additional post-transplant issues, have shown encouraging results, these studies are small scale and are limited by short-term follow-up. (
  • for example, more data need to be gathered about how to deliver DAAs to patients who are intubated post-transplantation, an issue particularly applicable to those who are undergoing a heart or lung transplant. (
  • The arrangement includes Bridge to Life's significant financial commitment to manufacture, trial, and launch Tevosol's portable ex-vivo lung perfusion (EVLP) machine and normothermic organ preservation platform. (
  • Together we can fulfill the great promise of this emerging clinical practice-and we're already working on exciting projects beyond lung transplantation and a host of other possibilities for the future. (
  • Organ transplantation is now the most cost-effective treatment for end-stage renal failure and the only available, life-saving treatment for end-stage failure of organs such as liver, lung and heart. (
  • Deciding about lung transplantation: informational needs of patients and support persons. (
  • A new technique for the decontamination of organs before transplantation using ultraviolet and red light irradiation has been developed by Brazilian and Canadian researchers and is described in an article titled "Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion," published in the journal Nature Communications . (
  • Bagnato's group partnered with researchers at the University of Toronto in Canada, which has the world's largest lung transplantation program, having performed 197 such surgeries in 2018 alone. (
  • In addition, there are limited data from animal studies 7-10 and historical case reports 11-15 suggesting that hematogenous spread of Naegleria amebae to extra-CNS organs might be possible, particularly late in the clinical course of PAM when tissue destruction is greatest and the blood-brain barrier is compromised. (
  • Transmission of Balamuthia mandrillaris through solid organ transplantation: utility of organ recipient serology for guide clinical management. (
  • This book, the proceedings of the 32nd International Conference on Transplantation and Clinical Immunology, held in Lyon, France, on May 25-26, 2000, addresses novel issues in terms of changing indications for transplantation in the management of organ failure, whether humans will remain the only source for organ procurement, prospects for engineering in organ replacement, and whether transplantation will remain the most appropriate approach to organ failure. (
  • The posttransplantation clinical course is generally complicated by dysfunction of various organ systems, and early or delayed neurologic complications may develop in 30-60% of patients. (
  • All 2652 livers made available to the Charité Universitätsmedizin Berlin from 2010 to 2016 were retrospectively analyzed and the clinical outcome of 526 liver transplantations during this time frame were evaluated. (
  • Accumulating experimental and clinical data have established the importance of DAMPs, which signal through innate pattern recognition receptors (PRRs) or DAMP-specific receptors, in regulating the alloresponse to solid organ transplantation (SOT). (
  • Due to the shortage of human organs, xenotransplantation emerged as an alternative potential option and its clinical potential is being explored with new technologies such as CRISPR Cas-9. (
  • Now in a study appearing online on June 9 in advance of the print publication of the July 1 print issue of the Journal of Clinical Investigation, Hisashi Bashuda and colleagues from Juntendo University investigate whether this approach can induce indefinite organ allograft survival in vivo, in six rhesus monkeys. (
  • Organ transplantation has been one of the miracles of modern-day medicine but, in addition to presenting enormous technical and clinical challenges, it throws up major ethical and legal is.Shipping may be from multiple locations in the US or from the UK, depending on stock availability. (
  • Organ transplantation has been one of the miracles of modern-day medicine but, in addition to presenting enormous technical and clinical challenges, it throws up major ethical and legal issues principally from the perspective of the donor. (
  • Research and clinical practice have contributed to making both whole organ and cellular transplantation viable therapeutic options for a broader range of patients. (
  • Topics will include donor consent, recipient education, organ acceptance practices and clinical protocols for managing risk of infection. (
  • In this paper, initially, a clinical case with brain death that ended up as an organ donor will be presented. (
  • Better outcomes, even with older and less-promising donor organs: new methods trialled by an EU-funded project have generated compelling results, widening the scope to transplant kidneys and livers that might otherwise not have been considered. (
  • Curcumin may play a protective role against oxidative stress in islet transplantation outcomes. (
  • 1-3 ) Since the advent of effective HIV therapy, transplantation outcomes have improved. (
  • This chapter provides an overview on how this has been undertaken and achieved over decades to ultimately provide outstanding outcomes on par with other organ transplantation results. (
  • [ 5 ] The tragic increase in the number of deaths due to opioid overdoses has led to a rise in available organs for solid organ transplantation and consequently a decrease in waiting time, if an HCV-uninfected patient is willing to accept an HCV-infected organ. (
  • The explosion in organ transplant technology has resulted in a tremendous shortage of available organs. (
  • The shortages of available organs for transplant have motivated some to question the need for such standards. (
  • The advancement of transplantation medicine has led, however, to a shortage in available organs and poses new quality and safety challenges. (
  • Until we learn to grow organs via tissue engineering, which is unlikely in the near future, xenotransplantation seems to be a valid approach to supplement human organ availability. (
  • Xenotransplantation is a promising strategy to alleviate the shortage of organs for human transplantation. (
  • Worldwide, the kidneys are the most commonly transplanted organs, followed by the liver and then the heart. (
  • Kidneys are the most common organs that are transplanted. (
  • In an opposite twist, Ganogen Research Institute CEO Eugene Gu is studying how to transplant human fetal hearts and kidneys into animals for future transplantation into human patients to address the shortage of donor organs. (
  • From 20th May 2020 all adults in England will be considered to have agreed to be an organ donor when they die, unless they have recorded a decision not to donate or are in one of the excluded groups. (
  • [24] the first allogeneic bone marrow transplantation was successfully executed in an acute leukaemia patient. (
  • Neurotoxicity with the development of the posterior reversible encephalopathy syndrome (PRES) imaging pattern is most typically noted in solid organ transplantation (SOT), allogeneic bone marrow transplantation (allo-BMT), and eclampsia. (
  • During perfusion - a procedure for decontaminating lungs before transplantation by replacing the blood with a preservation liquid - the organ to be transplanted is irradiated with red light with a wavelength of 660 nm until photodynamic oxidation eliminates the microorganisms in the tissue. (
  • The method was first tested on human lungs rejected for transplantation to determine whether the tissue viral load could be reduced by irradiation. (
  • VEGF expression is markedly increased in patients post-transplantation, and this can aid in the development of a blood supply to a transplanted organ, helping it survive and thrive. (
  • We think PKC-mediated VEGF transcriptional activation is a key component in the progression of cyclosporine-induced post-transplantation cancer," Pal said. (
  • In this chapter I sketch relevant aspects of the landscape that formed the background for my ethnographic field research in the Institute on live, related, renal transplantation in 2002. (
  • Kushenin, a flavonoid compound found within Sophora flavescens, inhibits the proliferation of hepatitis C virus (HCV), protects the liver and has anti-liver fibrosis effects in patients with HSV after renal transplantation. (
  • A heartbreaking renal transplantation: is norepinephrine the culprit to blame? (
  • [2] China is also involved in innovative transplant surgery such as face transplantation including bone. (
  • Organ transplantation is surgery in which a diseased or damaged organ is removed from a patient and replaced with a healthy organ from an organ donor. (
  • Blood tests to confirm the presence of the virus should be carried out, especially if the transplantation surgery is planned within 28 days of the travel. (
  • An organ transplant can give patients a new lease on life, but the surgery and the processes surrounding it can be daunting. (
  • Additional, nutritional supplements from providers such as can give the body the tools it needs to recover from the surgery and heal itself after the transplantation. (
  • aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results on all aspects of Advanced Organ Transplantation Surgery. (
  • Also, high quality research contributions describing original and unpublished results of conceptual, constructive, empirical, experimental, or theoretical work in all areas of Advanced Organ Transplantation Surgery are cordially invited for presentation at the conference. (
  • ICAOTS 2021 has teamed up with the Special Journal Issue on Advanced Organ Transplantation Surgery . (
  • however, larger series are needed in order to address the value of the robotic surgery in other areas of solid organ transplantation. (
  • Researchers, including Abbas Rana, MD, of the department of surgery at Baylor College of Medicine, analyzed data from the United Network for Organ Sharing (UNOS) database and the Social Security Administration Death Master File during a 25-year period (September 1987 to December 2012) to determine survival benefits of patients who underwent solid organ transplantation. (
  • Following the presentation, important moral challenges which initially formed medical ethics and some highlights of it in organ transplantation will be discussed in detail. (
  • Finally, we shall propose practical guidelines aiming at improving the practice of medical ethics in the emerging issue of organ transplantation. (
  • As a result, although the risk of transmission of Naegleria fowleri by donor organs is still unknown, it is unlikely to be zero so the risks of transplantation with an organ possibly harboring Naegleria fowleri should be carefully weighed for each individual organ recipient against the potentially greater risk of delaying transplantation while waiting for another suitable organ. (
  • In addition, a transplant recipient, living organ donor, will also attend to share their transplant story. (
  • Due to the unfortunate epidemic of opioid overdose deaths among people who inject drugs (PWID) in North America, there has been an increase in the availability of hepatitis C (HCV)-positive organs for transplantation and consequently the potential to decrease waiting times for solid organ transplantation if an HCV-uninfected recipient is willing to accept an HCV-positive donor. (
  • Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. (
  • The donor and recipient may be at the same location, or organs may be transported from a donor site to another location. (
  • Seeding transplanted organs with additional hematopoietic stem cells from the donor may also increase donor-recipient cross-talk and boost tolerance of the transplant. (
  • Here, we provide an overview of the impact of aging on both the allograft and the recipient and its effect on the immune response to organ transplantation. (
  • Impact of aging on donor organ and recipient immune system during organ transplantation. (
  • However, one does not think about the issue of organ transplantation until the serious disorder comes to their family and transplantation is the only solution. (
  • Disparities in access to transplantable organs can be attributed to the strong preference for antigen matching promulgated by the Organ Procurement and Transplantation Network (OPTN). (
  • The ACOT was established by the Amended Final Rule of the Organ Procurement and Transplantation Network (OPTN) ( 42 CFR Part 121 ) and, in accordance with Public Law 92-463, was chartered on September 1, 2000. (
  • c, Islet cluster procedure with transplantation of the liver and pancreatic islets injected into the portal vein of the transplanted liver. (
  • Curcumin preserves pancreatic islet cell survival and transplantation efficiency. (
  • Sulforaphane improved islet function in vivo, indicating that combination of a free radical scavenger and an antioxidant (sulforaphane) may be used to increase the effectiveness of islet transplantation. (
  • Association between liver transplant center performance evaluations and transplant volume," American Journal of Transplantation , vol. 14, no. 9, pp. 2097-2105, 2014. (
  • American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 13, no. 9, 2013, pp. 2458-61. (
  • Monkeying around to improve organ transplantation ( Organ transplantation is accompanied by. (
  • Could ticks help improve organ transplantation? (
  • One of the key issues in transplantation is the shortage of donor organs, says project coordinator Rutger Ploeg of the University of Oxford s Nuffield Department of Surgical Sciences in the UK. (
  • FIGURE C-1 Service areas of U.S. organ procurement organizations, 1997. (
  • Hematopoietic stem cell transplantation (HSCT) is established as a therapeutic option for treatment of hematological disorders. (
  • PRES developed in 21 (0.49%) of 4222 patients who underwent transplantation within the study period (no significant difference among SOT subtypes). (
  • However, although transmission via organ transplantation has not been documented for Naegleria fowleri , three clusters of transplant associated Balamuthia mandrillaris infection, another type of free-living ameba, have been reported to CDC 4-6 . (
  • End-organ disease has emerged as a principal cause of morbidity and mortality in HIV infection, but organ transplantation historically was not made available to HIV-infected individuals. (
  • Prior to 1995, treatment for HIV infection largely failed to extend life expectancy, and very few centers attempted solid-organ transplantation in HIV-infected individuals. (
  • Data from the early years of the epidemic are limited to case reports and small case series, but in general, mortality was high, particularly in those with unrecognized HIV infection at the time of transplantation, and HIV-infected patients experienced significantly higher 5-year mortality and rates of graft loss relative to HIV-uninfected individuals. (
  • These issues include the source and manner of organ procurement, as well as the allocation of organs within health systems. (
  • This includes features of the country called the Islamic Republic of Pakistan, the city of Karachi, and the Institute at which the dialysis and transplantations. (
  • Chronic renal disease, end stage renal disease, dialysis, and organ transplantation warrant special dental considerations. (
  • The August 29, 2000 Address of Blessed John Paul II is often quoted by those in support of obtaining vital organs for transplantation, but other statements by Pope John Paul II and a more recent statement by Pope Benedict XVI are ignored. (
  • A presumption of irreversibility of a lack of brain functioning, even if 'cerebrum, cerebellum and brain-stem' are included, is insufficient grounds for removing a patient's vital organs or for immediate autopsy, cremation, or burial. (
  • Pope Benedict XVI on November 7, 2008 specified: 'Individual vital organs cannot be extracted except ex cadavere . (
  • With this in mind, respect for human life from conception to natural death prohibits the removal of vital organs for transplant until after a patient has died. (
  • Two of the principles outlined by Pope John Paul II, the expectation that a potential donor is viewed as a fully human patient first, and the requirement that a donor of vital organs be dead before the organs are harvested, have long been cornerstones of transplant programs. (
  • This shortage of organs is now the limiting factor in treating many patients with chronic organ failure and has led to high numbers of patients on waiting lists. (
  • Physically severely ill patients associate their organ transplantation procedure with their hopes for health and wellbeing. (
  • Organ transplantation has developed at an incredibly rapid pace since its introduction in the 1950s, and it has become a life-saving procedure for patients with end-stage organ failure. (
  • b, Modified cluster procedure with transplantation of the liver only. (
  • While there are still issues that result from the procedure, thousands of lives have been extended thanks to organ transplantation procedures. (
  • In this respect, some people perceive organ transplantation as a life-saving procedure, while the others view it as a violation of human rights. (
  • Graft function was shown to depend largely on the gestational age and conditions of organ culture prior to transplantation. (
  • Prolongation of xenograft survival for up to 12 weeks was achieved with the use of peri-transplant and weekly treatment with anti-CD4 or anti-CD3 MAbs especially when the graft has been "immunomodulated" by using 90% O2 in organ culture. (
  • Should Transplantation Be Offered to Pediatric Foreign Nationals? (
  • This book offers a theoretical and practical overview of the specific ethical and legal issues in pediatric organ transplantation. (
  • The world-wide shortage has encouraged some countries-such as India-to trade in human organs. (
  • In my surgical clinics I focused on the (relative) certainty of the pathophysiology of disease and the predictability of how human organs respond to noxious. (
  • after all, the ways in which human cells and organs respond to disease processes are, except for minor variations, not very different whether an individual is a resident of Asia or North America. (
  • The Hon'ble High Court of Delhi in CWP No. 813/2004 vide its order dated 06.09.2004 had set up a Committee to examine the provisions of Transplantation of Human Organs Act, 1994, and the Transplantation of Human Organs Rules, 1995. (
  • The recommended changes required amendments in the Transplantation of Human Organs Act, 1994 and the Rules framed there under. (
  • Sale / purchase of human organs is already prohibited under Transplantation of Human Organs Act, 1994. (
  • Appropriate authorities established under this Act are responsible and empowered to check the illegal activities of human organs trafficking. (
  • This "Transplantation Law for Human Beings" has allowed "La Caja" to use organs for transplantation in patients with end-stage organ failure. (
  • That is why there can be no sale of human organs: the prospect of financial profit would put pressure on the poor to sell their organs for subsistence. (
  • A potential organ donor must always be seen first as a human being and a patient deserving of optimal medical care. (
  • With so many patients facing death without a transplant, it is not surprising that a black market for human organs has emerged. (
  • While many governments have enacted penalties for organ trafficking, few are aggressively seeking to eliminate the black market trade of human body parts. (
  • Perhaps even more worrisome than the deplorable practice of buying and selling human organs are the trends emerging in mainstream medicine. (
  • Legal aspects of human organ transplantation in Canada. (
  • One of the most touching forms of human compassion is related to the transplantation of human organs from a mother to a son, from a father to daughter, from a brother to a sister, from a friend to a friend, and from a stranger to a stranger. (
  • However, there are different schools of thought, between different religions and within each religion, regarding the issue of transplantation of human organs. (
  • These pigs had human genes that make their organs more compatible with human physiology. (
  • A few tens of thousand of pigs grown for their organs would represent just a small fraction of that total, and that they would be used to save human lives. (
  • The human body has sophisticated methods of destroying invasive agents, and transplanted organs are often viewed as invasive, dangerous entities. (
  • Due to rapid advances in transplantation medicine, the use of human organs for transplantation has steadily increased during the past decades. (
  • One consequence, though, is a shortage of human organs available for transplant. (
  • The idea of using pig organs as substitutes for human ones has been around for a while. (
  • In order to be able to experience the donor organ and the associated lifestyle changes not as a threat but a life enhancing event, patients often need to completely deny the existence of such risks in their everyday lives. (
  • Equally, psychological acceptance of the donor organ can present a formidable difficulty and may manifest as depressive symptoms or identity disorders. (
  • Tumors that develop after transplantation may have three potential sources: they may have pre-existed or could have been a recurrence of previous cancer and in both of these cases, a patient's pre-transplant immune system might have kept these cancers in check or cancer-causing viruses could have come from the donor organ. (
  • In 2013, Huang Jiefu altered his position on utilizing prisoners' organs, stating that death row prisoners should be allowed to donate organs and should be integrated into the new computer-based organ allocation system. (
  • Failing to donate organs because the system is biased is a self-fulfilling prophecy. (
  • Today, it is medically possible to donate organs following death brought about by medical assistance in dying. (
  • People with neurodegenerative conditions like amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, or multiple sclerosis (MS) are eligible to donate organs. (