A telecommunication system combining the transmission of a document scanned at a transmitter, its reconstruction at a receiving station, and its duplication there by a copier.
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Plant tissue that carries water up the root and stem. Xylem cell walls derive most of their strength from LIGNIN. The vessels are similar to PHLOEM sieve tubes but lack companion cells and do not have perforated sides and pores.
The fertilizing element of plants that contains the male GAMETOPHYTES.
The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed)
The sounds produced by humans by the passage of air through the LARYNX and over the VOCAL CORDS, and then modified by the resonance organs, the NASOPHARYNX, and the MOUTH.
An enzyme with high affinity for carbon dioxide. It catalyzes irreversibly the formation of oxaloacetate from phosphoenolpyruvate and carbon dioxide. This fixation of carbon dioxide in several bacteria and some plants is the first step in the biosynthesis of glucose. EC 4.1.1.31.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.
The functional hereditary units of PLANTS.
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
Biological mechanism that controls CIRCADIAN RHYTHM. Circadian clocks exist in the simplest form in cyanobacteria and as more complex systems in fungi, plants, and animals. In humans the system includes photoresponsive RETINAL GANGLION CELLS and the SUPRACHIASMATIC NUCLEUS that acts as the central oscillator.
A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The rate dynamics in chemical or physical systems.
An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.
Formation of an acetyl derivative. (Stedman, 25th ed)
An essential amino acid. It is often added to animal feed.
A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. They also modify transcription factors and CHROMATIN through ACETYLATION.
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
An enzyme that catalyzes the conversion of L-TYROSINE and 2-oxoglutarate to 4-hydroxyphenylpyruvate and L-GLUTAMATE. It is a pyridoxal-phosphate protein. L-PHENYLALANINE is hydroxylated to L-tyrosine. The mitochondrial enzyme may be identical with ASPARTATE AMINOTRANSFERASES (EC 2.6.1.1.). Deficiency of this enzyme may cause type II Tyrosinemia (see TYROSINEMIAS). EC 2.6.1.5.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
An anti-inflammatory 9-fluoro-glucocorticoid.
Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A pyrimidine base that is a fundamental unit of nucleic acids.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
A methylated nucleotide base found in eukaryotic DNA. In ANIMALS, the DNA METHYLATION of CYTOSINE to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In PLANTS, the methylated sequence is CpNpGp, where N can be any base.
A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.
Learning algorithms which are a set of related supervised computer learning methods that analyze data and recognize patterns, and used for classification and regression analysis.
A severe form of acute INFLAMMATION of the PANCREAS characterized by one or more areas of NECROSIS in the pancreas with varying degree of involvement of the surrounding tissues or organ systems. Massive pancreatic necrosis may lead to DIABETES MELLITUS, and malabsorption.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Disease having a short and relatively severe course.

A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea-pig atrial pacemaker cells at 29 degrees C and in ileum at 29 degrees C and 37 degrees C. (1/12667)

1 The affinity of 17 compounds for muscarine-sensitive acetylcholine receptors in atrial pacemaker cells and ileum of the guinea-pig has been measured at 29 degrees C in Ringer-Locke solution. Measurements were also made at 37 degrees C with 7 of them. 2 Some of the compounds had much higher affinity for the receptors in the ileum than for those in the atria. For the most selective compound, 4-diphenylacetoxy-N-methylpiperidine methiodide, the difference was approximately 20-fold. The receptors in the atria are therefore different the structure from those in the ileum. 3 The effect of temperature on affinity are not the same for all the compounds, tested indicating different enthalpies and entropies of adsorption and accounting for some of the difficulty experienced in predicting the affinity of new compounds.  (+info)

The mouse Aire gene: comparative genomic sequencing, gene organization, and expression. (2/12667)

Mutations in the human AIRE gene (hAIRE) result in the development of an autoimmune disease named APECED (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; OMIM 240300). Previously, we have cloned hAIRE and shown that it codes for a putative transcription-associated factor. Here we report the cloning and characterization of Aire, the murine ortholog of hAIRE. Comparative genomic sequencing revealed that the structure of the AIRE gene is highly conserved between human and mouse. The conceptual proteins share 73% homology and feature the same typical functional domains in both species. RT-PCR analysis detected three splice variant isoforms in various mouse tissues, and interestingly one isoform was conserved in human, suggesting potential biological relevance of this product. In situ hybridization on mouse and human histological sections showed that AIRE expression pattern was mainly restricted to a few cells in the thymus, calling for a tissue-specific function of the gene product.  (+info)

RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes. (3/12667)

RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression cloning, we identified the first "late" T lymphocyte associated transcription factor and named it "RANTES Factor of Late Activated T Lymphocytes-1" (RFLAT-1). RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression. While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.  (+info)

A concise promoter region of the heart fatty acid-binding protein gene dictates tissue-appropriate expression. (4/12667)

The heart fatty acid-binding protein (HFABP) is a member of a family of binding proteins with distinct tissue distributions and diverse roles in fatty acid metabolism, trafficking, and signaling. Other members of this family have been shown to possess concise promoter regions that direct appropriate tissue-specific expression. The basis for the specific expression of the HFABP has not been previously evaluated, and the mechanisms governing expression of metabolic genes in the heart are not completely understood. We used transient and permanent transfections in ventricular myocytes, skeletal myocytes, and nonmyocytic cells to map regulatory elements in the HFABP promoter, and audited results in transgenic mice. Appropriate tissue-specific expression in cell culture and in transgenic mice was dictated by 1.2 kb of the 5'-flanking sequence of FABP3, the HFABP gene. Comparison of orthologous murine and human genomic sequences demonstrated multiple regions of near-identity within this promoter region, including a CArG-like element close to the TATA box. Binding and transactivation studies demonstrated that this element can function as an atypical myocyte enhancer-binding factor 2 site. Interactions with adjacent sites are likely to be necessary for fully appropriate, tissue-specific, developmental and metabolic regulation.  (+info)

Integrin subunit gene expression is regionally differentiated in adult brain. (5/12667)

Integrins are a diverse family of heterodimeric (alphabeta) adhesion receptors recently shown to be concentrated within synapses and involved in the consolidation of long-term potentiation. Whether neuronal types or anatomical systems in the adult rat brain are coded by integrin type was studied in the present experiments by mapping the relative densities of mRNAs for nine alpha and four beta subunits. Expression patterns were markedly different and in some regions complementary. General results and areas of notable labeling were as follows: alpha1-limited neuronal expression, neocortical layer V, hippocampal CA3; alpha3 and alpha5-diffuse neuronal and glial labeling, Purkinje cells, hippocampal stratum pyramidale, locus coeruleus (alpha3); alpha4- discrete limbic regions, olfactory cortical layer II, hippocampal CA2; alpha6-most prominently neuronal, neocortical subplate, endopiriform, subiculum; alpha7-discrete, all neocortical layers, hippocampal granule cells and CA3, cerebellar granule and Purkinje cells, all efferent cranial nerve nuclei; alpha8-discrete neuronal, deep cortex, hippocampal CA1, basolateral amygdala, striatum; alphaV-all cortical layers, striatum, Purkinje cells; beta4-dentate gyrus granule cells; beta5-broadly distributed, neocortex, medial amygdala, cerebellar granule and Purkinje cells, efferent cranial nerve nuclei; alpha2, beta2, and beta3-mRNAs not detected. These results establish that brain subfields express different balances of integrin subunits and thus different integrin receptors. Such variations will determine which matrix proteins are recognized by neurons and the types of intraneuronal signaling generated by matrix binding. They also could generate important differences in synaptic plasticity across brain systems.  (+info)

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. (6/12667)

Dysfunction of the pancreatic beta cell is an important defect in the pathogenesis of type 2 diabetes, although its exact relationship to the insulin resistance is unclear. To determine whether insulin signaling has a functional role in the beta cell we have used the Cre-loxP system to specifically inactivate the insulin receptor gene in the beta cells. The resultant mice exhibit a selective loss of insulin secretion in response to glucose and a progressive impairment of glucose tolerance. These data indicate an important functional role for the insulin receptor in glucose sensing by the pancreatic beta cell and suggest that defects in insulin signaling at the level of the beta cell may contribute to the observed alterations in insulin secretion in type 2 diabetes.  (+info)

UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. (7/12667)

Uncoupling proteins (UCPs) are a family of mitochondrial transporter proteins that have been implicated in thermoregulatory heat production and maintenance of the basal metabolic rate. We have identified and partially characterized a novel member of the human uncoupling protein family, termed uncoupling protein-4 (UCP4). Protein sequence analyses showed that UCP4 is most related to UCP3 and possesses features characteristic of mitochondrial transporter proteins. Unlike other known UCPs, UCP4 transcripts are exclusively expressed in both fetal and adult brain tissues. UCP4 maps to human chromosome 6p11.2-q12. Consistent with its potential role as an uncoupling protein, UCP4 is localized to the mitochondria and its ectopic expression in mammalian cells reduces mitochondrial membrane potential. These findings suggest that UCP4 may be involved in thermoregulatory heat production and metabolism in the brain.  (+info)

The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution. (8/12667)

Latrophilin is a brain-specific Ca2+-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin. We now report the finding of two novel latrophilin homologues. All three latrophilins are unusual G protein-coupled receptors. They exhibit strong similarities within their lectin, olfactomedin and transmembrane domains but possess variable C-termini. Latrophilins have up to seven sites of alternative splicing; some splice variants contain an altered third cytoplasmic loop or a truncated cytoplasmic tail. Only latrophilin-1 binds alpha-latrotoxin; it is abundant in brain and is present in endocrine cells. Latrophilin-3 is also brain-specific, whereas latrophilin-2 is ubiquitous. Together, latrophilins form a novel family of heterogeneous G protein-coupled receptors with distinct tissue distribution and functions.  (+info)

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Lundby A, et al. (2012) Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep 2, 419-31 ...
Lundby A, et al. (2012) Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep 2, 419-31 ...
Sigma-Aldrich offers abstracts and full-text articles by [J M Müller, U Isele, E Metzger, A Rempel, M Moser, A Pscherer, T Breyer, C Holubarsch, R Buettner, R Schüle].
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
BACKGROUND: The combination of complete genome sequence information with expression data enables us to characterize the relationship between a proteins evolutionary origin or functional category and its expression pattern. In this study, mouse proteins were assigned into functional and phyletic groups and the gene expression patterns of the different protein groupings were examined by microarray analysis in various mouse tissues. RESULTS: Our results suggest that the proteins that are universally distributed in all tissues are predominantly enzymes and transporters. In contrast, the tissue-specific set is dominated by regulatory proteins (signal transduction and transcription factors). An increased tendency to tissue-specificity is observed for metazoan-specific proteins. As the composition of the phyletic groups highly correlates with that of the functional groups, the data were tested in order to determine which of the two factors - function or phyletic age - is dominant in shaping the ...
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Active-site concentrations can be defined as the concentrations of unbound, pharmacologically active substances at the site of action. In contrast, the total concentrations of the drug in plasma/organ/tissue also include the protein- or tissue-bound molecules that are pharmacologically inactive. Pla …
Cell Biologics provides custom services to our customers upon request. On request, we will isolate cells of any description from specific organs or tissues (any animal or human tissues) designated by our customers. Customer may ship to Cell Biologics either the already excised tissues or live mice or rats, and we will isolate the desired cell type and return a vial to Customer containing the prepared cells ready to use. If you have any special needs in isolation of endothelial cells, epithelial cells, macrophages, bone marrow derived cells or other cell types from animal or human tissues, please contact us for this special service. Let us know what you need and we will accommodate you. For details regarding these special services contact us at [email protected] We will contact you promptly within1 day. ...
Korang pernah tak mengalami bengkak pada mata yang terjadi dengan sendirinya? Entah dari mana tah dia datang. Tiba tiba je da muncul dekat kelopak mata. Pernah tak. Pernah tak? Orang biasa paggil ketumbit ke ketumbr tah. Aku pun tak sure. Ala, yang kalau orang nampak mata kita bengkak, orang akan selalu cakap: Haa. Tula, gi ngitai orang mandi la tu. Ntah pape je kan alasan tuh. ...
Of the many plant genes whose expressions are controlled by the circadian clock, one of the phosphoenolpyruvate carboxylase kinase genes in soya bean (Glycine max) exhibits the unusual property that its control is organ-specific - it is under circadian control in leaves but not in roots. Preliminary experiments suggest that the same is true for at least one gene in Arabidopsis thaliana. It will be important to define the extent and function of this phenomenon and the underlying mechanism.. ...
It has been assumed that exosomes are cellular trash bags for elimination of excess proteins, but many studies have shown that exosomes often exhibit certain specific markers, irrespective of the organ or cellular source. This suggests that certain proteins are transported to the exosomes with some degree of specificity. Additionally, distinct differences have been identified in the RNA and protein species present in exosomes, likely reflecting cellular and organ specificity. This second layer of complexity is dynamic and can change with the evolving status of the organ and cells within. Here, the pancreas is provided as an example, but this dynamism in exosomal contents presumably holds true for all organs. Therefore, exosome heterogeneity is a much more complex phenomenon than cellular heterogeneity and can be fleeting depending on stimuli and the functional status of the organ ...
TY - JOUR. T1 - A csontáttétképzodés molekuláris alapjai és célzott terápiája. AU - Tímár, J.. PY - 2010/3/1. Y1 - 2010/3/1. N2 - Formation of bone metastasis is a hallmark of the progression of several solid cancers, providing example for the organ specificity of the process. Bone metastasis may result in both venous and arterial dissemination. Though the molecular basis of the lytic and plastic bone metastasis formation is different, in reality these organ metastases represent a mixture of the two processes. The basis of bone metastasis formation is the activation of osteoclasts and the resulting bone resorption, initiating a vicious circle by activating the initiator cancer cell. The discovery of osteoclast-bone matrix interaction inhibitor bisphosphonates revolutionized the therapy of bone metastasis. Clarifying the molecular pathways involved in bone metastasis formation identified osteoclast differentiation as another feasible target. This process is under control of the TNF ...
TY - JOUR. T1 - Cloning of a novel amphiphysin isoform edna composed of multiple splicing variants and their differential tissue expression. AU - Tsutsui, Kimiko. AU - Maeda, Yukihide. AU - Tsutsui, Ken. AU - Sa, Kuniaki. AU - Seki, Shuji. AU - Tokunaga, Akira. PY - 1997/12/1. Y1 - 1997/12/1. N2 - Amphiphysin, an Stt3-domain containing protein concentrated in nerve terminals, is believed to be involved in the synaptic vesicle recycling. We have cloned cDNAs of a novel isoform of amphiphysin from mammals (man, rat, and mouse) by utilizing sequence information for homologous ESTs accumulated in databases. More than 10 subtypes of the isoform with 50-60 amino acid identity to the human amphiphysin were identified by a conventional library screening and PCR amplification of cDNA libraries. Each subtype probably represents a splicing variant of a single gene transcript. Analysis of mRNA expression in various tissues by RT-PCR showed that the isoform is more ubiquitously distributed than the canonical ...
ON THIS PAGE: You will find a list of common tests, procedures, and scans that doctors use to find the cause of a medical problem. Use the menu to see other pages.Doctors use many tests to find, or diagnose, cancer. They also do tests to learn if cancer has spread to another part of the body from where it started. If this happens, it is called metastasis. For example, imaging
I have to isolate total RNA/polyA+ RNA from various human tissues, healthy and diseased. In order to estimate the amount of starting material in grams, I need to know what RNA yield to expect from that tissue and how many grams of that particular tissue one can get from one donor. I was wondering if there are any reliable resources on : A) how much total RNA/polyA+ RNA one can get per gram of various human tissues B) how many grams of various tissues (anything imaginable, including weight of left and right ventricle, atria, septal wall, various brain regions, DRG, aorta, tongue, prostate etc. etc.) does an average human body have. Many thanks, B ...
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There are twelve primary tissue salts and these are are made up from minerals naturally found in rocks and soil. Our bodies can utilize these if we eat food that has been grown in mineral rich soil but so often the ground has become so depleted that, along with poor lifestyle choices, we may suffer from a lack of miner
Gluecksohn, waelsch S. and Rota, T R., Development in organ tissue culture of kidney rudiments from mutant mouse embryos. (1963). Subject Strain Bibliography 1963. 428 ...
Following the irreversible loss of function of the brain (brain death), the different organs and tissues will give up their function one after another. Due to the fact that organs retain certain amounts of energy sources they can maintain their function or the function of individual cells for some time, even after brain death. Those supravital functions include (electrically stimulated) muscle contraction as much as 20 hours after death. The time until the last cell dies depends on the specific organ. ...
Cell Biologics provides custom cell isolation service upon request. On request, we will isolate cells of any description from specific organs or tissues (any animal or human tissues) designated by our customers. If you would like to use of Custom Cell Isolation Service, for details regarding these special services, please contact us at [email protected] Thank You!. ...
Video created by 杜克大学 for the course 人体生理学导论. Welcome back! In this module we consider how the circulatory system works to deliver oxygen and nutrients to the specific organs. We start with a discussion of the electrical and mechanical ...
Video created by Universidad Duke for the course Introductory Human Physiology. Welcome back! In this module we consider how the circulatory system works to deliver oxygen and nutrients to the specific organs. We start with a discussion of the ...
41. While cost blтod have played a role in slowing the activation gviing programs (costs are in the range giving blood propecia 60,000 to 250,000, depending on the specific organ), these figures do not accurately reflect the cost of this procedure to society. 72, 276в282.
Studying human brain disorders is one of the most challenging fields in biomedical research. Besides the fact that the brain is incredibly complex, its just plain difficult to peer into it. For one thing, its not practical, let alone ethical, to drill into an affected persons skull and collect brain cells to learn about their…
Ethris proprietary Stabilized Non-Immunogenic mRNA (SNIM® RNA) platform includes a toolbox of technologies to generate mRNA molecules that are stable, result in production in the patients own body of therapeutic proteins, and which escape recognition by the bodys immune system. These mRNA technologies paired with Ethris proprietary delivery systems for organ- and cell- targeted delivery of mRNA has generated a pipeline of Transcript Therapies, which Ethris is developing to treat serious diseases ...
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We all know that our body is made up of thousands of organs and all these organ combine together to form into various organ systems. All these organ s
Although alopecia areata (AA) is one of the most frequent organ-specific autoimmune diseases, the association of AA with other autoimmune diseases and the genetic basis of the association remain to be analyzed. Among the autoimmune diseases associated with AA, autoimmune thyroid disease was most frequent (10.0%), followed by vitiligo (2.7%) and rheumatoid arthritis (0.9%) but not type 1 diabetes (0.0%). The prevalence of thyroid-related autoantibodies in patients with AA was significantly higher than that in controls (TSH receptor antibody [TRAb]: 42.7% vs 1.2%, P = 1.6 × 10(-46); thyroid peroxidase antibody: 29.1% vs 11.6%; P = 1.7 × 10(-6)), whereas the prevalence of islet-related autontibodies was comparable between patients with AA and control subjects. The frequency of DRB1*15:01-DQB1*06:02, a protective haplotype for type 1 diabetes, was significantly higher in TRAb-positive (12.8%, P = .0028, corrected P value [Pc] = .02) but not TRAb-negative (7.1%, not significant) patients with AA ...
Authors: Xue-Ru Wu, MD, professor, Urology and Pathology; Joseph B. Guttenplan, PhD, research associate professor, Environmental Medicine and Basic Science. Butyl-hydroxybutyl-N-nitrosamine (BBN) is a powerful carcinogen that specifically causes bladder cancer in rodents, the reason for such a high degree of organ specificity is unclear. BBN is a primary metabolite of the environmental carcinogen, dibutylnitrosamine and hence a potential human carcinogen. Mutagenesis induced by BBN in a chromosomally incorporated mutagenesis reporter gene was measured in bladder urothelial cells and smooth muscle cells of mice or rats and compared with mutagenesis in liver, kidney, ureter and forestomach. Since mutagenesis in the reporter gene is a surrogate for mutagenesis in general, researchers hypothesized mutations also induced in critical growth control genes would contribute to the tumor formation induced by BBN. Researchers found mutagenesis correlated with the organ specificity for cancer induction by ...
Understanding how genes are expressed and regulated in different tissues is a fundamental and challenging question. However, most of currently available biological databases do not focus on tissue-specific gene regulation. The recent development of computational methods for tissue-specific combinational gene regulation, based on transcription factor binding sites, enables us to perform a large-scale analysis of tissue-specific gene regulation in human tissues. The results are stored in a web database called TiGER (Tissue-specific Gene Expression and Regulation). The database contains three types of data including tissue-specific gene expression profiles, combinatorial gene regulations, and cis-regulatory module (CRM) detections. At present the database contains expression profiles for 19,526 UniGene genes, combinatorial regulations for 7,341 transcription factor pairs and 6,232 putative CRMs for 2,130 RefSeq genes. We have developed and made publicly available a database, TiGER, which summarizes and
miRNA is a set of small, non-coding RNA molecules that regulate gene expression post transcription. These molecules have an impact on a wide range of biological functions such as cell cycle control, stem cell differentiation, immune modulation, viral replication, and metabolic control. As the aforementioned processes are involved in the pathology of various diseases, tests performed on miRNAs help in disease treatment. Moreover, miRNAs can be easily manipulated than proteins, thus making them more useful for clinical diagnostics and therapeutics applications. The global miRNA tools and services market was valued at $146 million in 2015 and is expected to reach $620 million by 2022, growing at a CAGR of 23.4% during the forecast period. It is expected to witness significant growth owing to the rise in incidence of cancer, auto-immune, and cardiovascular diseases. In addition, miRNA molecules possess specific properties, such as higher tissue and organ specificity; and ability to cross the ...
Lee, J. C., Zhao, J. T., Clifton-Bligh, R. J., Gill, A., Gundara, J. S., Ip, J. C., Glover, A., Sywak, M. S., Delbridge, L. W., Robinson, B. G. and Sidhu, S. B. (2013), MicroRNA-222 and MicroRNA-146b are tissue and circulating biomarkers of recurrent papillary thyroid cancer. Cancer, 119: 4358-4365. doi: 10.1002/cncr.28254 ...
Understanding regulation of developmental events has increasingly required the use of tissue-specific expression of diverse factors affecting plant growth and environmental responses. To allow for cloning of presumptive promoters with tissue-specific activities, we created two plant expression vectors with multiple cloning sites upstream of a Gateway cassette for expression of either untagged or YFP-tagged genes of interest (Michniewicz et al., 2015) by modifying the pEarleyGate100 and pEarleyGate104 constructs (Earley et al., 2006). For fast and easy tissue-specific expression of desired genes, we further developed a set of Gateway-compatible tissue-specific gene expression vectors that allow for the expression of YFP-tagged or untagged proteins driven by various promoters (see table below). Additional vectors will be added to this table as they are created. These vectors provide an invaluable resource to the plant community, allowing for rapid generation of a variety of tissue-specific ...
In this study, tissue-specific enhancers (and promoters) were identified based on the presence of H3K27ac and absence of H3K4me3. Most previous studies in Drosophila have used the binding pattern of known cardiogenic TFs to identify cardiac-specific enhancers genome-wide (Jin et al., 2013; Junion et al., 2012). However, this approach can only be applied to well-characterized TFs with a known role in the tissue of interest, and for which an antibody is available. ChIP against TFs will also only identify a subset of the enhancers involved, unless a clear master regulator of that tissues development is known. By contrast, H3K27ac is thought to unravel functionally active enhancers (Bonn et al., 2012b) without any prior knowledge of the TFs involved.. In this study, we show that presence of the H3K27ac mark is not an absolute predictor of tissue-specific activity, as even in purified population of cardiac nuclei only ∼60% of identified active enhancers drive expression in this cell type. Although ...
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Background Variation in gene expression is extensive among tissues, individuals, strains, populations and species. The interactions among these sources of variation are relevant for physiological...
What Relationship do the Spine and Nervous System Have to Organs? - If the brain is unable to communicate with the nervous system and spine, the organs that are connected via nerves will have a much harder time functioning as efficiently as possible. For example, if a particular nerve is pinched by the spine and is connected to a specific organ, its possible that when prolonged this problem can cause lasting effects.
The study and characterization of chemicals and other agents for toxic properties is often undertaken on the basis of specific organs and organ system...
Brains that go bump in the night. Brain science has come a long way in the last 200 years. We look back at the early efforts of the phrenologists to map personality, behaviour and mental abilities onto specific organs of the brain with amusement. But that is only because their methodology was so woefully inadequate. These…
Viral surface protein implicated in the binding to specific host surface molecule(s). This binding can lead to virion entry into the host cell, it can trigger signaling pathways, or it can allow the virion to be carried by the host cell to a specific organ ...
Video created by Duke University for the course Introductory Human Physiology. Welcome back! In this module we consider how the circulatory system works to deliver oxygen and nutrients to the specific organs. We start with a discussion of the ...
Plastic Surgery Procedures Available Surgical procedures that people undertake to alter their appearance or that of specific organs in their body is known as
Author: Brian Hoyle The skin-the body's largest organ- teems with an unexpectedly broad variety of bacterial species, according to Martin Blaser of New York University (NYU) School of Medicine in New York, N.Y., and his collaborators. There has been a lot of work on the gastrointestinal tract … but, in contras... More... ...
Comprehensive collection of high-quality human total protein extracts ready for electrophoresis. Quickly confirms tissue-specific abundance of your protein. Easily accesses hard-to-obtain human tissues, including brain regions and fetal tissues.
Comprehensive collection of high-quality human total protein extracts ready for electrophoresis. Quickly confirms tissue-specific abundance of your protein. Easily accesses hard-to-obtain human tissues, including brain regions and fetal tissues.
TP53TG3, 0.1 ml. May play a significant role in TP53/p53-mediating signaling pathway.Tissue specificity:Strongly expressed in testis.
Lysine acetylation is a major posttranslational modification involved in a broad array of physiological functions. Here, we provide an organ-wide map of lysine acetylation sites from 16 rat tissues analyzed by high-resolution tandem mass spectrometry. We quantify 15,474 modification sites on 4,541 proteins and provide the data set as a web-based database. We demonstrate that lysine acetylation displays site-specific sequence motifs that diverge between cellular compartments, with a significant fraction of nuclear sites conforming to the consensus motifs G-AcK and AcK-P. Our data set reveals that the subcellular acetylation distribution is tissue-type dependent and that acetylation targets tissue-specific pathways involved in fundamental physiological processes. We compare lysine acetylation patterns for rat as well as human skeletal muscle biopsies and demonstrate its general involvement in muscle contraction. Furthermore, we illustrate that acetylation of fructose-bisphosphate aldolase and ...
Fingerprint Dive into the research topics of Organ specificity of glucocorticoid-sensitive tyrosine aminotransferase. Separation from aspartate aminotransferase isoenzymes. Together they form a unique fingerprint. ...
The ability to resolve protein members of the hsp70 multigene family by two-dimensional Western blotting permitted the characterization of antibodies which were specific in discriminating constitutively expressed hsc70 isoforms from stress-inducible hsp70 isoforms. This antibody characterization demonstrated that basal levels of hsp70 isoforms were present in the cerebellum of the control rabbit and that these were elevated following hyperthermia, whereas levels of hsc70 were similar in control and hyperthermic tissue. Multiple isoforms of hsp70 were detected but tissue-specific differences were not apparent in various organs of the rabbit. However, species differences were observed as fewer hsp70 isoforms were noted in rat and mouse. In the control rabbit, higher levels of hsc70 protein were present in neural tissues compared to non-neural tissues. Following physiologically relevant hyperthermia, induction of hsp70 was greatest in non-neural tissues such as liver, heart, muscle, spleen, and kidney
From NCBI Gene:. The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]. From UniProt: ...
Tissue specific architecture of nutrient dependent responses in D. melanogaster. The overall aim of this project is to examine the role of tissue-specific changes in mRNA translation in response to dietary restriction (DR) and to examine their role in modulating metabolism, muscle activity and healthspan using D. melanogaster. We have previously demonstrated that modulation of mRNA translation is a key output of the TOR pathway that mediates DR responses on metabolism and lifespan. We have now established a ribotag based method in D. melanogaster to study tissue-specific mRNA translation. Tissue-specific mRNAs are isolated following ribosome affinity purification of tissue-specific tagged ribosomal proteins followed by polysomal profiling. Using this Ribotag approach tissue-specific changes under DR have been measured in muscle, fat, gut, heart, neurons, germline and malpighian tubules, showing a highly tissue specific response upon DR. We are developing mechanistic models of gene expression ...
Skeletal muscle tissue forms the muscles which are attached to the bones, these muscles are voluntary, which means they can be controlled with conscious thought, and they help us to walk, run, or move our body in some other way. The smooth and cardiac muscle tissue are involuntary, which means they are not controlled by conscious thought, they work automatically. Connective tissue provides support throughout the body. The main purpose of connective tissue is to join together the other tissues of the body. It connects the bone to the muscle with tendons, and the bones to other bones with ligaments. It also can keep two bones from rubbing together, like the cartilage between the vertebrae in the spinal column and the joints. Nerve tissue gives your body control. It sends out signals for information and processes data coming into the brain from different areas of the body. Some scientists also consider the blood and lymph fluid to be tissue, it is responsible for carrying nutrients all through the ...
Researchers identify important molecular players for the formation of embryonic cell structures Understanding the molecular mechanisms underlying the mesmerising transformation of a fertised egg into a complex organism is a key goal of developmental biology, and one driving extensive investigations. Different tissues and organs derive from three primordial germ layers: endoderm, mesoderm and ectoderm. How do they become specified, and how do they subsequently diversify to form different structures? Researchers of the CRTD teamed up with international scientists to investigate this question together with international colleagues. In particular, they addressed the lateral plate mesoderm (LPM) - the germ layer that gives rise to the cardiovascular, blood, kidney and smooth muscle cell fates among others, and whose origin was poorly understood.. Through a combination of genetic tools and live imaging techniques, the scientists identified a small enhancer of the zebrafish-specific gene draculin (drl) ...
actually the cause has to do with the adaptation of the eye to light. the darkness causes all the retinen in cone cells to associate with its opsin partner, leading to an increased sensitivity of the cell to intense light. When the light is turned on, it overwhelms the receptor. It takes a few minutes for the eye to adapt and to switch from rod cells to cone cells. I believe the term for this is receptor up-regulation ...
C) no, not necessarily... it depends how much damage there is... but pain sensation is both a physiological and psychological responce... many people have very traumatic sports injuries and they dont feel the pain to much after the event... as adrenaline may well delay a pain responce... but we also have other endogenous pain killers in bodies (endogenous opioids, neurotransmitters...etc ...
Technical information on organs like specification, type of construction, pipe measurements etc.. Historical information on organs. Very often when an organ was built, parts of the previous instrument were reused by enlarging and restoring the organ, for instance, or replacing certain stops. Also, organs or parts of organs were sold from one church to another. It is important to store these changes to an instrument in order to document the development of a specific organ.. Archive information consisting of (1) written documents containing letters, contracts, descriptions, documentations, etc. and (2) picture documents containing photos, paintings, drawings, etc. Proposals, contracts, descriptions, letters from various authorities, the parish, the organ builder, the organist or the organ expert are an important background to the decisions made when building, restoring or repairing an organ.. Person information. Information on organ builders, organists, companies etc. that in one way or another ...
This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. You understand what makes a tissue specific and depict key signaling pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors.
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Certain types of tumors preferentially seek out and colonize specific organs through metastasis. New research shows that tumor cells send signals throughout the body to prepare these organs for the arrival of metastatic cells. The signals are transmitted through microscopic bubble-like compartments known as exosomes, which set the stage for cancer cells to take root ...
Last Monday and Tuesday I got to witness our juniors and seniors that are currently taking anatomy to dissect minks. The students all came into class promptly and started to work on a variety of tasks including removing and identifying specific organs and regions of the mink. While laughing and joking with Mrs. McGonigal about ureters,...
A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative). [GOC:add, ISBN:0781735149 ...
DNA does not change All cells in an organism have the same set of genes (usually) DNA sequence does not change but genes can be switched on/off Gene regulation must be a reversible process Some gene activities are required in all cell types (housekeeping genes) e.g. synthesis of RNA Others are tissue specific e.g. to make muscle proteins (myosin, actin) in muscle cells
A joint Chinese and British research team have undertaken a detailed molecular analysis of the fossilised tissues of Confuciusornis sanctus and worked out how
What are Tissue salts? You may have seen Tissue salts in health food shops or in your local Holland and Barrat, but What are they? Tissue salts were developed by Dr. Schuessler, a German Doctor and biochemical medic, identified that when human cells are turned to ash, they exhibit 12 inorganic minerals. When these 1
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in…
Read Patho-Epigenetics of Infectious Disease by with Rakuten Kobo. Epigenetic modification of cellular genomes is a fascinating means of regulating tissue- and cell type-specific gene exp...
Pericyte Biology in Different Organs von - Englische Bücher zum Genre Biologie günstig & portofrei bestellen im Online Shop von Ex Libris.
This effort will focus on characterizing how different organ systems participate in and control immune function, and how immune cells are integrated in the normal function of each organ. For example, this effort could help improve the understanding of the intestine as the entire organ level, and determining the differences between a response occurring there versus in another
From August 16 until August 26, Jo Caimo is in residency at iMAL. During this 10-days residency he continues to work on his project Human Organ Concert, together with Sjoerd Leijten.
A re-examination of the organ specificity of lens antigens. Exp Eye Res. 1968 Jan;7(1):11-29. PubMed PMID 4966535 Clayton RM, ...
These encompass two (gastric and enterohepatic) groups, showing different organ specificity. Importantly, some species, such as ...
Spar, I. L.; Bale, W. F.; Wolfe, D. E.; Goodland, R. L. (1956). "Organ specificity of I-131 labeled rabbit kidney eluates in ... Miller, L. L.; Bly, C. G.; Bale, W. F. (1954). "Plasma and tissue proteins produced by non-hepatic rat organs as studied with ... Bale, W. F.; Spar, I. L. (1954). "In-vivo localization of rat organ antibodies in ovaries, adrenals, and other tissues". J. ...
Pancreatic engineering is a testament to the molecular specificity of organs. Scientists have not yet been able to produce an ... ranging from end organ failure to cosmetic surgery. One of the greatest limitations to organ transplantation derives from organ ... which can be used in artificial organ and tissue regeneration. Organ and tissue transplantation treat a variety of medical ... Complete organ reconstruction is still in the early levels of development. Researchers are able to take the tissue from a donor ...
These organs are in direct contact with the urinary tract. As a result, urine samples contain cfDNA derived from apoptotic ... Both sensitivity and specificity levels are higher than 80% in most of the past clinical trials. In some papers, the ... Sensitivity and specificity of some ucfDNA applications are comparable to other standards in liquid biopsy. However, clinical ... However, the detection of cffDNA in maternal urine has a low sensitivity and specificity due to the short length and half-life ...
Organ-specific lymphocyte homing is important for antigen-specificity and in avoiding autoimmune cross-reactions. Lymphocyte ... High endothelial venules (HEVs) are cells found in secondary lymphoid organs that express large quantities of cell adhesion ... This happens so that the full repertoire of antigenic specificities of lymphocytes is continuously represented throughout the ... Lymphocyte homing receptor control of organ-specific lymphocyte trafficking is thought to prevent autoreactivity in immune ...
Boswell HD, Dräger B, McLauchlan WR, Portsteffen A, Robins DJ, Robins RJ, Walton NJ (November 1999). "Specificities of the ... Plant Cell Tissue Organ Cult. 38: 241-247. doi:10.1007/bf00033883. ... O-acylpseudotropine This enzyme exhibits absolute specificity for the exo/3beta configuration found in pseudotropine as tropine ...
Boswell HD, Dräger B, McLauchlan WR, Portsteffen A, Robins DJ, Robins RJ, Walton NJ (November 1999). "Specificities of the ... Plant Cell Tissue Organ Cult. 38: 241-247. doi:10.1007/bf00033883. ...
... s may also occur elsewhere: very rarely in solid organs (most notably the heart and liver) and hollow organs (such as ... In this condition, the teratomas may contain B cells with NMDA-receptor specificities. After surgery, a risk exists of regrowth ... Both forms may contain or appear to contain complete organ systems, even major body parts such as a torso or limbs. Fetus in ... Beyond the newborn period, symptoms of a teratoma depend on its location and organ of origin. Ovarian teratomas often present ...
Blood flow, blood transit time, and organ blood volume, can all be calculated with reasonable sensitivity and specificity. This ... "Radiation - Effects on organs of the body (somatic effects)". Encyclopedia Britannica. Retrieved 2021-03-21. Simpson G (2009 ... New software allow the reconstruction of data in non-orthogonal (oblique) which help in the visualization of organs which are ... Individualize the examination and adjust the radiation dose to the body type and body organ examined. Different body types and ...
The specificity of a particular virus for a specific tissue is known as its tropism. Viruses in tracer studies are all ... neurotropic (capable of infecting neurons). The viral tracer may be introduced in peripheral organs, such as a muscle or gland ... Ugolini G (1995). "Specificity of rabies virus as a transneuronal tracer of motor networks: transfer from hypoglossal ...
The sensitivity and the specificity of these criteria for differentiating AIP from neoplasia are unknown. In cases of systemic ... other organ involvement with IgG4-related disease, pancreatic histology and response to steroid therapy. In 2002, the Japanese ... other organ involvement, and response to steroid therapy. Computed tomography (CT) findings in AIP include a diffusely enlarged ... "Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations". Arthritis & ...
There has been much conjecture to explain such apparently striking tissue specificity. Major determinants of where BRCA1- and ... An innate genomic deficit impairs normal responses and exacerbates the susceptibility to disease in organ targets. This theory ... and reproductive organs; and bone marrow suppression (reduced blood cell production that leads to anemia). Women having ... BRCA2-associated hereditary cancers occur are related to tissue specificity of the cancer pathogen, the agent that causes ...
A high organ specificity is important because the injected activity should accumulate in the organ under investigation, as ... the image of the target organ can be obscured. Also, high organ specificity allows for the reduction of the injected activity, ... Radiopharmaceuticals containing 99mTc are currently being applied in the determining morphology of organs, testing of organ ... there should be a high activity ratio of the target organ to nontarget organs. If there is a high activity in organs adjacent ...
... each level in the hierarchy may reflect a variable degree of specificity or "granularity" from one System Organ Class to ... according to the level of specificity required. The Lowest Level Term (LLT) level provides maximum specificity. The terminology ... The 27 System Organ Classes (SOCs) represent parallel axes that are not mutually exclusive. This characteristic, called "multi- ... The highest or broadest level is System Organ Class (SOC), further divided into High-Level Group Terms (HLGT), High-Level Terms ...
Ultrasound imaging, like MRI, does not use radiation and is safe for examination of the pelvis and female reproductive organs. ... Overall, it is estimated that MRI has a sensitivity of 74% and specificity of 91% for the detection of adenomyosis. Diagnosis ... Overall, it is estimated that transvaginal ultrasonography has a sensitivity of 79% and specificity of 85% for the detection of ...
... is expressed in a total of seventy-four organs. In a study of ninety-five individuals, twenty-seven different tissues ... had RNA sequencing completed to determine the tissue-specificity of the protein-coding genes. C11orf42 is expressed in a ...
The liver is the major organ that metabolizes ethanol due to its high concentration of these enzymes. The average human ... allows for greater specificity of function. This occurs for the processing of ethanol in the human body. The enzymes required ... A basic organizing theme in biological systems is that increasing complexity in specialized tissues and organs, ...
... salivary gland and other organs. Like other mollicutes, they show a high host specificity. In the first taxonomy of Mollicutes ...
Female midges most likely detect their hosts using a specialized organ called a Johnston's organ, a collection of sensory cells ... There is evidence of host specificity and selection of particular biting sites for some species. Corethrella species have been ...
Top-ranked Radiomic features feed into an optimized IsoSVM classifier resulted in a sensitivity and specificity of 65.38% and ... The Multiparametric Radiomics was tested on two different organs and diseases; breast cancer and cerebrovascular accidents in ... Only 73% of cases were classifiable by the neuroradiologist, with a sensitivity of 97% and specificity of 19%. These results ... The MPRAD framework classified malignant from benign breast lesions with excellent sensitivity and specificity of 87% and 80.5 ...
Pharmacokinetic studies are needed to determine how quickly a drug will be cleared from the body organs and the hepatic blood ... MS analyzers are useful in these studies because of their shorter analysis time, and higher sensitivity and specificity ... mass spectrometry provides structural identity of the individual components with high molecular specificity and detection ...
The specificity of drugs cannot be talked about without mentioning the affinity of the drugs. The affinity is a measure of how ... The same receptor can be located on different organs, and even on different types of tissues. There are also different subtypes ... It is this phenomenon that gives rise to drug specificity. Of course, drugs do not only act on receptors: they also act on ion ...
The specificity theory, which states that pain is "a specific sensation, with its own sensory apparatus independent of touch ... The British psychologist, Edward Titchener, pronounced in his 1896 textbook, "excessive stimulation of any sense organ or ... Moritz Schiff was first to definitively formulate the specificity theory of pain when, in 1858, he demonstrated that touch and ... but rather implicated the heart as the central organ for the sensation of pain. He was the principal advocate of the cardio- ...
The sensitivity of RF for established rheumatoid arthritis is only 60-70% with a specificity of 78%. High levels of rheumatoid ... such as that associated with tissue or organ rejection. In such instances, RF may serve as one of several serological markers ... Falkenburg, W.J.J. (November 2015). "IgG Subclass Specificity Discriminates Restricted IgM Rheumatoid Factor Responses From ...
... gene expression and antibody specificities contribute toward the repertoire of B lymphocytes in various lymphoid organs in mice ...
Because any medication that could reduce the inflammation of CPPD bears a risk of causing organ damage, treatment is not ... However, even this method suffers from poor sensitivity, specificity, and inter-operator agreement. These two modalities ...
Major determinants of where BRCA1/2 hereditary cancers occur are related to tissue specificity of the cancer pathogen, the ... genomic deficit in a tumor suppressor gene impairs normal responses and exacerbates the susceptibility to disease in organ ... Kim ST, Lim DS, Canman CE, Kastan MB (December 1999). "Substrate specificities and identification of putative substrates of ATM ... Rodriguez M, Yu X, Chen J, Songyang Z (December 2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) ...
Strict organ specificity (ovaries) The plant lacks defense reactions Strict polar, oriented growth in the first infection stage ...
... manipulation of the ligands in a complex to create specificity so that the complex will be taken up by a certain cell or organ ...
This is very useful in showing detailed views of moving organs or structures with higher anatomical variation, which is more ... indirectly by competition studies between unlabeled drug and radiolabeled compounds known apriori to bind with specificity to ... Brain images obtained with an ordinary (non-PET) nuclear scanner demonstrated the concentration of FDG in that organ. Later, ...
in females, for the limited gynecological palpations of internal organs when you are unable to access the vaginal vault or it ... The DRE has a 50% specificity for benign prostatic hypoplasia.[1] Vigorous examination of the prostate in suspected acute ... organ damage, anal bruising, and foreign objects in the rectal cavity; ...
... specificity for the presence of the infection. Other laboratory findings in Lassa fever include lymphocytopenia (low white ... The other symptoms arising from the affected organs are: *Gastrointestinal tract *Nausea ...
A particularly telling case of this effect is host specificity in pathogenic ascomycetes and specifically, in venturia, the ... damaged organs, strokes, high blood pressure, and loss of vision. Sickle red blood cells also have a shortened lifespan and die ... increasing the risk of blood clots and possibly depriving vital organs of oxygen.[33] Some complications associated with sickle ...
The specificity of the amount of choice is important, as too little or too great a degree of choice may negatively influence ... It is the effect of the constitution and present state of our organs." ...
... organ donations, unhealthy foods, mortgage deductions, taxing internet sales, Wal-Mart, casinos, ethanol subsidies, and ... One commentary characterizes the remark as making economics an approach rather than a subject matter but with great specificity ...
"for theories concerning the specificity in development and control of the دستگاه ایمنی and the discovery of the principle for ... "for their discoveries concerning 'genetic regulation of organ development and programmed cell death'"[۷۷] ...
Two or more positive criteria have a sensitivity of 88.2% and a specificity of 92.0% of describing GPA.[13][18] ... It is a form of vasculitis (inflammation of blood vessels) that affects small- and medium-size vessels in many organs but most ... In generalised non-organ-threatening disease, remission can be achieved with a combination of methotrexate and corticosteroids ... GPA treatment depends on its severity and whether it has caused organ damage.[8] ...
In medicine, a biomarker can be a traceable substance that is introduced into an organism as a means to examine organ function ... thus providing ultimately the best specificity for medical purposes.[2] ...
... but at the risk of complications from any solid organ transplant (such as rejection, infections, or side-effects of the ... 98% specificity)[6]. 1st degree relative general population age cholesterol mg/dL mmol/L mg/dL mmol/L ...
Pathogen-specificity[edit]. The parts of the innate immune system have different specificity for different pathogens. ... Most leukocytes differ from other cells of the body in that they are not tightly associated with a particular organ or tissue; ... In tissues, organ-specific macrophages are differentiated from phagocytic cells present in the blood called monocytes. ... Identification and removal of foreign substances present in organs, tissues, blood and lymph, by specialized white blood cells ...
... ic specificity[edit]. Antigenic specificity is the ability of the host cells to recognize an antigen specifically as a ... egg white and proteins from transplanted tissues and organs or on the surface of transfused blood cells. ... Antigen specificity is due primarily to the side-chain conformations of the antigen. It is measurable and need not be linear or ... "Antigen specificity - Medical Terms". Steadyhealth.com. 2010-12-17. Archived from the original on 2011-09-30. Retrieved 2012-07 ...
"Low host specificity of herbivorous insects in a tropical forest". Nature. 416 (6883): 841-844. Bibcode:2002Natur.416..841N. ... The organs sit in the haemocoel and are bathed in the haemolymph. The 'heart' is little more than a single tube which pulses ( ...
animal organ regeneration. • positive regulation of cell proliferation. • positive regulation of cell size. • positive ...
The specificity of this technique is to modify three parameters during the treatment. VMAT delivers radiation by rotating ... In afterloading a hollow tube or applicator is placed surgically in the organ to be treated, and the sources are loaded into ... To spare normal tissues (such as skin or organs which radiation must pass through to treat the tumor), shaped radiation beams ... Biegala M, Hydzik A (2016). "Analysis of dose distribution in organs at risk in patients with prostate cancer treated with the ...
... and post organ transplant.[110] In those at high risk immunization may reduce the risk of heart disease.[111] Whether ... and specificity of 90-95% when compared with viral culture.[30] ... systems are medically suppressed to prevent transplant organ ...
TCRs have very high degree of antigen specificity, despite of fact that the affinity to the peptide/MHC ligand is in the ... during the early stages of their development in primary lymphoid organs (thymus for T cells, bone marrow for B cells). ... Each recombined TCR possess unique antigen specificity, determined by the structure of the antigen-binding site formed by the α ... Extracellularly, the TCR co-receptor defines the specificity of the TCR to MHC class I or II molecule, and increases binding ...
"World Allergy Organ J. 4 (2): 13-37. doi:10.1097/WOX.0b013e318211496c. ISSN 1939-4551. PMC 3500036. PMID 23268454.. ... A CAP-RAST has greater specificity than RAST; it can show the amount of IgE present to each allergen.[48] Researchers have been ... "World Allergy Organ J. 7 (1): 1-14. doi:10.1186/1939-4551-7-10. PMC 4005619. PMID 24791183.. ... multiple-organ autoimmune disorder primarily affecting the small intestine.[55][56][57] ...
Rapid diagnostic tests kits may or may not recognize P. knowlesi because of their specificity. ... heart and kidney without evidence of chronic inflammatory reaction in the brain or any other organ examined. The spleen and ...
Million M, Raoult D (February 2013). "Species and strain specificity of Lactobacillus probiotics effect on weight regulation". ... a risk exists for the passage of viable bacteria from the gastrointestinal tract to the internal organs (bacterial ...
... and the organ of Corti to vibrate, activating ultimately the acoustic sensor cells, the inner hair cells of the organ of Corti ... High accuracy, precision, sensitivity and specificity of proposed method are fully acceptable for clinical practice and for ...
Transmission via infected blood products and through organ donation is also theoretically possible during times of outbreak, ... "A single mutation in chikungunya virus affects vector specificity and epidemic potential". PLOS Pathogens. 3 (12): e201. doi ...
Most of the aaRSs of a given specificity are evolutionarily closer to one another than to aaRSs of another specificity. However ... tissues and organs during adult or fetal development or both, including pathways associated with angiogenesis, inflammation, ... Most of the aaRSs of a given specificity also belong to a single class. However, there are two distinct versions of the LysRS ...
The canonical example of a ligand-binding protein is haemoglobin, which transports oxygen from the lungs to other organs and ... although the surrounding amino acids may determine the exact binding specificity). A large number of such motifs has been ...
Surprise organ discovered in mice, Nature News, 2 March 2006 Media related to Thymus (organ) at Wikimedia Commons Virtual ... Immature thymocytes undergo a process of selection, based on the specificity of their T-cell receptors. This involves selection ... Unlike many other organs, the thymus is at its largest in childhood. The thymus reaches maximum weight (20 to 37 grams) by the ... Galen was the first to note that the size of the organ changed over the duration of a person's life. In the nineteenth century ...
Zlotnik A, Burkhardt AM, Homey B (August 2011). "Homeostatic chemokine receptors and organ-specific metastasis". Nature Reviews ... while the N-terminal domain of the chemokine receptor determines ligand binding specificity.[11] ... expressed on cells destined for homing in cells to these organs). Using these ligands is possible routing antigen-presenting ...
Coffey RJ (March 2009). "Deep brain stimulation devices: a brief technical history and review". Artificial Organs. 33 (3): 208- ... specificity but only a 67% sensitivity. As of 2017 some scientists hypothesized that changes in the gut flora might be an early ...
Using the traditional "organ specific" and "non-organ specific" classification scheme, many diseases have been lumped together ... and production of large amounts of antibodies of varying specificities, some of which may be self-reactive (see below). ... In this form of the disease, the absence of lymphocytes can accelerate organ damage, and intravenous IgG administration can be ... Local syndromes which affect a specific organ or tissue: *Endocrinologic: Diabetes mellitus type 1, Hashimoto's thyroiditis, ...
... may be screened for in animal discrimination and self-administration models which have high sensitivity albeit low specificity. ... forming organs (B). *Antithrombotics *Antiplatelets. *Anticoagulants. *Thrombolytics/fibrinolytics. *Antihemorrhagics * ...
The avian vocal organ is called the syrinx;[11] it is a bony structure at the bottom of the trachea (unlike the larynx at the ... The specificity of bird calls has been used extensively for species identification. The calls of birds have been described ...
The biological basis of this specificity, however, is poorly understood. A... ... The nitrosamines exhibit remarkable species and tissue specificity in their carcinogenic action (Shank and Magee, 1981). ... Mehta, R., Labuc, G.E., Urbanski, S.J. and Archer, M.C., 1984, Organ specificity in the microsomal aci:ivation and toxicity of ... Archer M.C., Silinskas K.C., Zucker P.F. (1986) Mechanism of Organ Specificity in Nitrosamine Carcinogenesis. In: Kocsis J.J., ...
... Tobias Baskin BaskinT at missouri.edu Tue Oct 26 19:22:29 EST 1999 *Previous ... Greetings, Sorry to be a pedant, but could the distinction between organ and tissue please be maintained? Roots, sepals, leaves ... etc, are organs; epidermis, xylem, sclerenchyma, etc, are tissues. This is a very useful distinction and ought to be preserved ...
Target organ specificity of major neuropeptide stimulants in locust excretory systems Message Subject (Your Name) has sent you ... Thus, hormonal control of these major organs of the excretory system appears to be clearly separated. Lom-K and Locusta-DH ...
Organ specificity of lymphocyte migration: mediation by highly selective lymphocyte interaction with organ-specific ... Evidence is presented that the organ specificity of lymphocyte migration is determined by selective interaction of lymphocytes ... surface receptors specific for organ-restricted endothelial cell determinants mediate the antigen-independent organ specificity ... Even greater specificity is shown by certain homogeneous lymphocyte populations, i.e. thymic lymphomas. Some lymphomas bind ...
Organ specificity in the circadian control of plant gene expression. S. Sullivan, M. Shenton, H.G. Nimmo ... Organ specificity in the circadian control of plant gene expression Message Subject (Your Name) has forwarded a page to you ... exhibits the unusual property that its control is organ-specific - it is under circadian control in leaves but not in roots. ...
Tissue layer and organ specificity of trichome formation are regulated by GLABRA1 and TRIPTYCHON in Arabidopsis ... Tissue layer and organ specificity of trichome formation are regulated by GLABRA1 and TRIPTYCHON in Arabidopsis ... Tissue layer and organ specificity of trichome formation are regulated by GLABRA1 and TRIPTYCHON in Arabidopsis ... Tissue layer and organ specificity of trichome formation are regulated by GLABRA1 and TRIPTYCHON in Arabidopsis ...
Organ specificity in autoimmune diseases: thyroid and islet autoimmunity in alopecia areata. May 14, 2015. ... Although alopecia areata (AA) is one of the most frequent organ-specific autoimmune diseases, the association of AA with other ...
... autoantibodies in organ and non-organ-specific autoimmune diseases confers high specificity for insulin-dependent diabetes ... Neither patients with organ- or non-organ-specific autoimmune diseases without IDDM nor healthy controls had autoantibodies ... are limited to IDDM or also occur in other organ- or non-organ-specific autoimmune disorders. We determined the frequency of ...
Increasing organ-non-specificity with increasing reactivity of rheumatoid factor with heterologous gamma globulin. ... Increasing organ-non-specificity with increasing reactivity of rheumatoid factor with heterologous gamma globulin. ...
ORGAN SPECIFICITY AND LACTATE-DEHYDROGENASE ACTIVITY. DIFFERENTIAL INHIBITION BY UREA AND RELATED COMPOUNDS. WA WITHYCOMBE, DT ... ORGAN SPECIFICITY AND LACTATE-DEHYDROGENASE ACTIVITY. DIFFERENTIAL INHIBITION BY UREA AND RELATED COMPOUNDS ... ORGAN SPECIFICITY AND LACTATE-DEHYDROGENASE ACTIVITY. DIFFERENTIAL INHIBITION BY UREA AND RELATED COMPOUNDS ... ORGAN SPECIFICITY AND LACTATE-DEHYDROGENASE ACTIVITY. DIFFERENTIAL INHIBITION BY UREA AND RELATED COMPOUNDS ...
Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns ... Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Reports ... Here, we provide an organ-wide map of lysine acetylation sites from 16 rat tissues analyzed by high-resolution tandem mass ... Here, we provide an organ-wide map of lysine acetylation sites from 16 rat tissues analyzed by high-resolution tandem mass ...
"Organ specificity of a vacuolar Ca2 +-binding protein RVCaB in radish and its expression under Ca2 +-deficient conditions, ... Organ specificity of a vacuolar Ca2 +-binding protein RVCaB in radish and its expression under Ca2 +-deficient conditions. ... Organ specificity of a vacuolar Ca2 +-binding protein RVCaB in radish and its expression under... Yuasa, Koji; Maeshima, ... Organ specificity of a vacuolar Ca2 +-binding protein RVCaB in radish and its expression under Ca2 +-deficient conditions. ...
Organ specificity of the bladder carcinogen 4-aminobiphenyl in inducing DNA damage and mutation in mice. Jae-In Yoon, Sang-In ... We demonstrate an organ-specificity of 4-ABP in inducing repair-resistant DNA-adducts in bladder, kidney and liver of ... Organ specificity of the bladder carcinogen 4-aminobiphenyl in inducing DNA damage and mutation in mice ... Organ specificity of the bladder carcinogen 4-aminobiphenyl in inducing DNA damage and mutation in mice ...
Organ Specificity and Dwarfism. * Organ-Specific Gibberellins in Rice: Roles and Biosynthesis ...
Diabetic microvasculopathy is characterized with organ specificity, which mainly affect retinal, glomerular and peripheral ... Mechanisms of Organ Specificity in Diabetic Microvasculopathy. Author: WangHui. Tutor: LouJinNing. School: Beijing Union ... Therefore, it is necessary to further investigate mechanisms of organ specificity in diabetic microvasculopathy for prevention ... Diabetic microvasculopathy is characterized with organ specificity, which mainly affect retinal, glomerular and peripheral ...
... of disease-specific sensitivities and specificities in reader-based multi-disease diagnostic studies of paired organs. N. ...
... Fingerprint Dive into the research topics of Organ specificity of glucocorticoid-sensitive tyrosine aminotransferase. ...
... development of a 5hmC tissue map by characterizing the genomic distributions of 5hmC in 19 human tissues derived from ten organ ... report a comprehensive 5hmC tissue map and analysis of 5hmC genomic distributions in 19 human tissues derived from 10 organ ... types impedes drawing generalized conclusions about how 5hmC is implicated in transcription activity and tissue specificity. To ... This tissue specificity of transcription was observed in a manner consistent with the known biology of tissue and organ systems ...
Specificity. *Sensitivity. *Indeterminate results. *(and 2 more...). 2000. All. 18 Years and older (Adult, Older Adult). ... RCT- Comparing Testimonial Versus Documentary Organ Donation Video Education. *Organ Donation. *Behavioral: Control ending - ... Also searched for Organ Transplants, Transplant, Organ Donation and more. See Search Details ... Clinical Study of Microchimerism and cfDNA as Biomarkers for Acute Rejection After Organ Transplantation. *Organ Transplant ...
... and specificity of logistic regression analysis (93.33%) were the best scores among the six models in the test set. ,i, ... i,Background,/i,. Multiple organ failure (MOF) may lead to an increased mortality rate of moderately severe (MSAP) or severe ... Multiple organ failure (MOF) has a higher mortality rate than OF [2]. Until organ dysfunction occurs, it is difficult to ... The severity of organ dysfunction in AP can be graded by the modified Marshall grading system [3]. The existing AP scoring ...
Kinetics and specificity of SEB-induced T cell proliferation. The percentages of BrdU+ cells among mature SEB-specific and ... 1⇓). Peaks of DNA synthesis by Vβ8+ cells were found in all organs tested. CD4 SP cell proliferation was maximal 16-24 h after ... DNA synthesis was preceded by massive migration of Vβ8+ cells from blood to lymphoid organs, in which the early activation ... Globally, the results obtained with the SEB system suggest that Ag-specific T cells first encounter the Ag in organs, in which ...
Organ Specificity of Each Nuclear Factor. We also examined distribution of nuclear factors identified in this study. When the − ... 1992) Sequences flanking the hexameric G-box core CACGTG affect the specificity of protein binding. Plant Cell 4:485-496. ... In this paper, we mapped the wound-responsive regions of the FAD7 promoter in each vegetative organ. Moreover, we detected the ... 5′-Deletion analysis of the FAD7promoter concerning wound responsiveness in each organ. Tobacco plants carrying a GUS gene ...
... sistem organ (sr-el); Sistematike (nov); organ seestem (sco); sistem organ (id); układ narządów (pl); gøgnskipan (fo); Organski ... group of organs that work together to verga perform one or more functions; collection of organs joined in structural unit to ... group of organs that work together to verga perform one or more functions; collection of organs joined in structural unit to ... File nella categoria "Organ systems". Questa categoria contiene 16 file, indicati di seguito, su un totale di 16. ...
However, the majority of these studies have been performed with individual organs in isolation. Separately, little is known ... Organ Specificity * RNA, Messenger / metabolism * Rats * Rats, Sprague-Dawley * Reverse Transcriptase Polymerase Chain Reaction ... Each of the test drugs generated specific gene expression patterns which were unique for all three organs. Hierarchical cluster ... However, the majority of these studies have been performed with individual organs in isolation. Separately, little is known ...
Organ and species specificity in the stimulation of transitional epithelial cell growth by fibroblasts. European urology. 2001 ... Organ and species specificity in the stimulation of transitional epithelial cell growth by fibroblasts. / Staack, Andrea; ... Staack, A., Alexander, T., Merguerian, P., & Terris, M. K. (2001). Organ and species specificity in the stimulation of ... Staack, Andrea ; Alexander, Terri ; Merguerian, Paul ; Terris, Martha K. / Organ and species specificity in the stimulation of ...
Adequate organ function. Exclusion Criteria:. *Prior malignancy, except carcinoma in situ of the skin or cervix treated with ... MTD of dual specificity CD38 and BCMA CAR-T cells [ Time Frame: 4 weeks ]. The highest dose of dual specificity CD38 and BCMA ... Biological: Dual Specificity CD38 and bcma CAR-T Cells 1) Biological: Dual Specificity CD38 and BCMA CAR-T Cells,2)1-5X10E6/Kg ... This is a phase 1/2 study designed to determine the safety of dual specificity CD38 and BCMA CAR-T cells and the feasibility of ...
... organ and tissue specificity; and the problem of extrapolation from rodent models to human populations [128]. ... This flavonoid has been shown to inhibit chemically induced carcinogenesis in several organs [87,88,89,90,101,102,103,104,105 ... Lakshmanan, M.R.; Pope, J.L.; Olson, J.A. The specificity of a partially purified carotenoid cleavage enzyme of rabbit ... Kaplan, L.A.; Lau, J.M.; Stein, E.A. Carotenoid composition, concentrations, and relationships in various human organs. Clin. ...
Target specificity among canonical nuclear poly(A) polymerases in plants modulates organ growth and pathogen response ... Target specificity among canonical nuclear poly(A) polymerases in plants modulates organ growth and pathogen response. ...
ENDOTHELIUM ORGAN-SPECIFICITY : EVIDENCE AND CHARACTERISATION OF AN ADHESION REGULATING MOLECULE, NAMED ARM-1 ...
Mechanism of Organ Specificity in Nitrosamine Carcinogenesis. Pages 1005-1011. Archer, Michael C. (et al.) ... Drug Interactions with Macrolide Antibiotics: Specificity of Pseudo-Suicide Inhibition and Induction of Cytochrome P-450 ...
  • The nitrosamines exhibit remarkable species and tissue specificity in their carcinogenic action (Shank and Magee, 1981). (springer.com)
  • Greetings, Sorry to be a pedant, but could the distinction between organ and tissue please be maintained? (bio.net)
  • Ubiquitous expression of the positive regulator GL1 in the absence of the negative regulator TRY leads to ectopic trichome formation not only on additional organs but also in subepidermal tissue layers. (biologists.org)
  • We propose a model of how the tissue and organ specificity of trichome induction is regulated in normal development. (biologists.org)
  • However, the lack of genome-wide 5hmC profiles in different human tissue types impedes drawing generalized conclusions about how 5hmC is implicated in transcription activity and tissue specificity. (nature.com)
  • To meet this need, we describe the development of a 5hmC tissue map by characterizing the genomic distributions of 5hmC in 19 human tissues derived from ten organ systems. (nature.com)
  • Washietl, S., Kellis, M. & Garber, M. Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals. (nature.com)
  • Systemic treatment of mice with a chimeric peptide consisting of the SMSIARL homing peptide, linked to a proapoptotic peptide that disrupts mitochondrial membranes, caused tissue destruction in the prostate, but not in other organs. (pnas.org)
  • We propose tissue-specific antigen processing by 20S proteasomes as a potential mechanism to control organ-specific immune responses. (rupress.org)
  • To investigate whether tissue-restricted pathology is influenced by organ-specific processing of MHC class I ligands, we analyzed the subunit composition of 20S proteasomes from various organs and compared their ability to generate peptides and T cell epitopes which are involved in the induction of organ-specific pathology of the small intestine. (rupress.org)
  • Systemic vasculitis in MRL/lpr mice is genetically controlled with cumulative effects of multiple gene loci, each of which has tissue specificity. (wiley.com)
  • However, the mechanisms responsible for the tissue or organ distribution of vasculitis have not been well studied. (wiley.com)
  • Decellularization (also spelled decellularisation in British English) is the process used in biomedical engineering to isolate the extracellular matrix (ECM) of a tissue from its inhabiting cells, leaving an ECM scaffold of the original tissue, which can be used in artificial organ and tissue regeneration. (wikipedia.org)
  • Organ and tissue transplantation treat a variety of medical problems, ranging from end organ failure to cosmetic surgery. (wikipedia.org)
  • Scientists can use the acquired ECM scaffold to reproduce a functional organ by introducing progenitor cells, or adult stem cells (ASCs), and allowing them to differentiate within the scaffold to develop into the desired tissue. (wikipedia.org)
  • The produced organ or tissue can be transplanted into a patient. (wikipedia.org)
  • This process of decellularizing tissues and organs is still being developed, but the exact process of taking a tissue from a donor and removing all the cellular components is considered to be the decellularization process. (wikipedia.org)
  • As far as introducing the different liquidized chemicals and enzymes to an organ or tissue, perfusion and immersion decellularization techniques have been used. (wikipedia.org)
  • Perfusion decellularization is applicable when an extensive vasculature system is present in the organ or tissue. (wikipedia.org)
  • The sensitivity and specificity of sonography were 45.7% and 91.8% making contrast-enhanced sonography more sensitive than sonography and almost as sensitive as CT when detecting 'traumatic, abdominal solid organ injuries. (medindia.net)
  • Diagnosis of visceral leishmaniasis: the sensitivities and specificities of traditional methods and a nested PCR assay. (semanticscholar.org)
  • This factor is relatively organ and species-specific. (elsevier.com)
  • Here we analyse the expression patterns of lncRNAs across developmental time points in seven major organs, from early organogenesis to adulthood, in seven species (human, rhesus macaque, mouse, rat, rabbit, opossum and chicken). (nature.com)
  • Our analyses identified approximately 15,000 to 35,000 candidate lncRNAs in each species, most of which show species specificity. (nature.com)
  • We have investigated the induction of DNA-adducts in relation to mutagenesis in bladder and various non-target organs of transgenic Big Blue® mice treated weekly (i.p.) with a representative aromatic-amine compound, 4-aminobiphenyl (4-ABP), for six weeks, followed by a six-week recovery period. (aacrjournals.org)
  • In confirmation, we show a predominant and sustained mutagenic effect of 4-ABP in bladder, and much weaker but significant mutagenicity of 4-ABP in the kidney and liver of carcinogen-treated mice, as reflected by the elevation of background cII mutant frequency in the respective organs. (aacrjournals.org)
  • Organ specific drug targeting was explored in mice as a possible alternative to surgery to treat prostate diseases. (pnas.org)
  • While these cross-reactive T cells did not cause pathology in immunocompetent mice, adoptive transfer into immunodeficient mice resulted in organ-specific inflammation of the small intestine but not the colon, despite comparable migration in both tissues, and elevated expression of murine heat shock protein 60 (mu HSP60) * in the colon ( 2 ). (rupress.org)
  • Although alopecia areata (AA) is one of the most frequent organ-specific autoimmune diseases, the association of AA with other autoimmune diseases and the genetic basis of the association remain to be analyzed. (thyroidmanager.org)
  • Neither patients with organ- or non-organ-specific autoimmune diseases without IDDM nor healthy controls had autoantibodies against both GAD65 and ICA512(IA-2). (nih.gov)
  • Understanding of organ-specific autoimmune diseases is hampered by a dilemma: although some autoantigens are ubiquitously expressed, they provoke local pathogenic immune responses ( 1 , 2 ). (rupress.org)
  • Visceral organs specific expression. (abcam.com)
  • In this study, regulatory specificity was investigated by dissecting the genetic and molecular requirements that allow the Hox protein Abdominal A to activate wingless in only a few cells of its broad expression domain in the Drosophila visceral mesoderm. (biologists.org)
  • Lymphoma (lymposarcoma) in animals is a type of cancer defined by a proliferation of malignant lymphocytes within solid organs such as the lymph nodes, bone marrow, liver and spleen. (wikipedia.org)
  • Biopsy of affected lymph nodes or organs confirms the diagnosis, although a needle aspiration of an affected lymph node can increase suspicion of the disease. (wikipedia.org)
  • Using the upper limit of normal both amylase assays appeared sensitive but somewhat nonspecific (specificities of 88.9% and 86%, respectively). (annals.org)
  • Each of the test drugs generated specific gene expression patterns which were unique for all three organs. (nih.gov)
  • Organ specificity was examined for each transcript using a gene expression atlas. (lww.com)
  • THE vast majority of tissues and organs of the adult plant are formed postembryonically. (genetics.org)
  • We demonstrate an organ-specificity of 4-ABP in inducing repair-resistant DNA-adducts in bladder, kidney and liver of carcinogen-treated animals, which accords with the bioactivation pathway of this chemical in the respective organs. (aacrjournals.org)
  • Although single organ specific toxicity assays have already been commercialised, it is not yet possible to assess toxicity in the three main organs (brain, heart and liver) in the same animal. (nc3rs.org.uk)
  • ZeGlobalTox have created a new genetically modified line of zebrafish to drive the expression of unique fluorescent proteins in the three main organs (brain, heart and liver) enabling assessment of acute multi-organ toxicity and teratogenicity in the same animal. (nc3rs.org.uk)
  • Microbial infections, mutations of cellular proteins or failure in immunoregulation can activate CD8 + T cells causing organ-specific autoimmune pathology. (rupress.org)
  • We studied the organ specificity of BR biosynthesis in Arabidopsis, using two different approaches: We analyzed the expression of BR-related genes using real-time quantitative reverse transcriptase-polymerase chain reaction, and analyzed endogenous BRs using gas chromatography-mass spectrometry. (plantphysiol.org)
  • Before starting this study, we cloned the second BR-6-oxidase ( BR6ox2 ) gene from Arabidopsis and found that the encoded enzyme has the same substrate specificity as the enzyme encoded by the previously isolated 6-oxidase gene ( BR6ox1 ) of Arabidopsis. (plantphysiol.org)
  • To gain a comparative insight into the similarities and differences into how organs are built and how plants respond to stress, the transcriptomes of Arabidopsis and rice were compared at the level of gene orthology and functional categorisation. (pubmedcentralcanada.ca)
  • Organ specific transcripts in rice and Arabidopsis display less overlap in terms of gene orthology compared to the orthology observed between both genomes. (pubmedcentralcanada.ca)
  • Of the many plant genes whose expressions are controlled by the circadian clock, one of the phosphoenolpyruvate carboxylase kinase genes in soya bean ( Glycine max ) exhibits the unusual property that its control is organ-specific - it is under circadian control in leaves but not in roots. (biochemsoctrans.org)
  • Organ specificity in the plant circadian system is explained by different light inputs to the shoot and root clocks. (nih.gov)
  • Thus, hormonal control of these major organs of the excretory system appears to be clearly separated. (biologists.org)
  • 2007). At four days post fertilisation (dpf) the vital organs of zebrafish are already fully functional and any drug-induced effect can be easily detected and evaluated. (nc3rs.org.uk)
  • Bone serves a number of purposes: it provides protection for vital organs, a lever for locomotion, a reservoir for calcium, and the site of adult hematopoiesis. (jci.org)
  • It is proposed that lymphocyte surface receptors specific for organ-restricted endothelial cell determinants mediate the antigen-independent organ specificity of lymphocyte migration. (nih.gov)
  • Archer M.C., Silinskas K.C., Zucker P.F. (1986) Mechanism of Organ Specificity in Nitrosamine Carcinogenesis. (springer.com)
  • Studies with pMad-Gsk (an antibody specific to Zw3/Gsk3-β-phosphorylated Mad) in larval wing disks revealed that this phosphorylation event is Wg dependent (via an unconventional mechanism), is restricted to anterior-dorsal sensory organ precursors (SOP) expressing Senseless (Sens), and is always co-expressed with the mitotic marker phospho-histone3. (genetics.org)
  • Skin is the interface between the internal organs and the environment, and as such plays a crucial role in the body's defense mechanism. (jci.org)
  • Under this mechanism and proper physiological conditions, treatments can diffuse equally to all of the cells within the organ. (wikipedia.org)
  • What are the prognostic factors for influenza in solid-organ transplant recipients? (elsevier.es)
  • What other therapeutic measures should be adopted in solid-organ transplant recipients with influenza infection? (elsevier.es)
  • How should neuraminidase inhibitors be used in solid-organ transplant recipients with renal function impairment? (elsevier.es)
  • The recent application of the bone marrow techniques in clinical solid organ transplantation has yielded results that could fundamentally alter the role of immunosuppression in organ transplant recipients in the near future. (omicsonline.org)
  • Drug-induced toxicity was not confined to an 'individual' organ. (nih.gov)
  • Accordingly, the transcriptional profile of the organs was studied using a toxicity panel of 30 genes derived from literature. (nih.gov)
  • Collectively, these data demonstrate drug-induced multi-organ toxicity. (nih.gov)
  • Furthermore, our findings underscore the importance of transcriptional profiling during inadequate phenotypic anchorage and suggest that whole blood may be judiciously used as a surrogate for drug-induced extra-hematological organ toxicity. (nih.gov)
  • Ravindra K, Leventhal J, Song D, Ildstad ST (2012) Chimerism and Tolerance in Solid Organ Transplantation. (omicsonline.org)
  • Transplantation has become standard of care to treat end-organ failure, replacing a failed organ with a functioning one. (omicsonline.org)
  • Donor-specific tolerance has been referred to as the "Holy Grail" of organ transplantation. (omicsonline.org)
  • Conventional HSCT involves the use of aggressive myeloablative conditioning that would not be acceptable in the context of organ transplantation where the recipients have severe physiologic derangement from end stage organ failure. (omicsonline.org)
  • Recent success with 'mini bone marrow transplants' using non-myeloablative conditioning in elderly patients with hematologic malignancy [ 1 ] have opened a new avenue for the application of chimerism in solid organ transplantation. (omicsonline.org)
  • One of the greatest limitations to organ transplantation derives from organ rejection caused by antibodies of the transplant recipient reacting to donor antigens on cell surfaces within the donor organ. (wikipedia.org)
  • These results suggest that different regulatory mechanisms mediate the wound-induced expression of the FAD7 gene in aerial and subterranean organs. (plantphysiol.org)
  • Low temperature and humidity (LTH) stress during soybean maturation in the field promotes pre-harvest mildew, resulting in damage to different organs of soybean fruits to different extents, but relatively little information on the resistance mechanisms in these fruits is available. (frontiersin.org)
  • Evidence is presented that the organ specificity of lymphocyte migration is determined by selective interaction of lymphocytes with specialized endothelial cells. (nih.gov)
  • DNA synthesis was preceded by massive migration of Vβ8 + cells from blood to lymphoid organs, in which the early activation marker CD69 was first up-regulated. (jimmunol.org)
  • CAR-T cell therapy has shown promising results for the treatment of relapsed or refractory Multiple Myeloma,however, a subset of patients relapse due to the loss of target in tumor cells.Dual Specificity CD38 and BCMA CAR-T cells can recognize and kill the malignant cells through recognition of CD38 or BCMA. (clinicaltrials.gov)
  • This is a phase 1/2 study designed to determine the safety of dual specificity CD38 and BCMA CAR-T cells and the feasibility of making enough to treat patients with relapsed or refractory Multiple Myeloma. (clinicaltrials.gov)
  • To evaluate the feasibility and safety of dual specificity CD38 and BCMA CAR-T cells in patients with relapsed or refractory Multiple Myeloma. (clinicaltrials.gov)
  • To evaluate the duration of in vivo persistence of adoptively transferred T cells, and the phenotype of persisting T cells.Real Time polymerase chain receptor (RT-PCR) and Flow cytometry(FCM) analysis of PB,BM and lymph node will be used to detect and quantify survival of universal dual specificity CD38 and BCMA CAR-T cells over time. (clinicaltrials.gov)
  • Many organs arise from simple sheets and tubes of cells. (elifesciences.org)
  • Cell sliding may prove to be a common way to shape organs, many of which feature non-symmetrical twisted tubes of cells. (elifesciences.org)
  • Shoot apical meristems ( SAMs ), which contain populations of plant stem cells that produce lateral organs such as leaves, are the primary starting points for establishing positional information in the plant shoot. (plantcell.org)
  • The biological basis of this specificity, however, is poorly understood. (springer.com)
  • In the future, learning how to control cell sliding could help researchers to create organs and biological structures in the laboratory that could be used in organ transplants and regenerative medicine. (elifesciences.org)
  • Amniotic fluid cell-free fetal RNA can provide biological information on multiple fetal organ systems. (lww.com)
  • Fingerprint Dive into the research topics of 'Organ specificity of glucocorticoid-sensitive tyrosine aminotransferase. (elsevier.com)
  • Additionally, DPL can be used in nonemergency circumstances as a means of detecting solid-organ injury or HVI requiring laparotomy. (medscape.com)
  • Our study provides a resource of candidate lncRNAs and their patterns of expression and evolutionary conservation across mammalian organ development. (nature.com)
  • With respect to the representation of odorant molecules, two extreme organizations of glomerular activity patterns may be envisaged, depending on the tuning specificity of the afferents to individual glomeruli. (jneurosci.org)
  • However, most of the reported uses of CRISPR/Cas9 in plants have focused on modifying one or a few genes, and thus the overall specificity, types of mutations, and heritability of gene alterations remain unclear. (frontiersin.org)
  • Endogenous BRs and the expression of BR-related genes were detected in all organs tested. (plantphysiol.org)
  • Multiple organ failure (MOF) may lead to an increased mortality rate of moderately severe (MSAP) or severe acute pancreatitis (SAP). (hindawi.com)
  • Organ failure (OF) is a hallmark complication of severe acute pancreatitis (SAP) and may be found in approximately 20% of all cases of AP [ 1 ]. (hindawi.com)
  • Circulating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses. (annals.org)
  • In normal animals, very small numbers of cycling mature lymphocytes are detected in peripheral lymphoid organs ( 9 , 10 ). (jimmunol.org)
  • Also searched for Organ Transplants , Transplant , Organ Donation and more. (clinicaltrials.gov)
  • DPL was found to have a sensitivity of 100% but a specificity of only 43% for bowel injuries. (medscape.com)
  • The objective of our study was to prospectively compare the diagnostic value of sonography, contrast-enhanced sonography, and CT for the detection of solid organ injuries in blunt abdominal trauma patients,' said Massimo Valentino, MD, lead author of the study. (medindia.net)
  • But after some cases, they changed their attitude completely and now they greatly appreciate this tool, and they often ask me to carry out contrast enhanced ultrasound to rule out possible injuries to the solid organs of the abdomen, especially the spleen. (medindia.net)
  • Organ specificity of lymphocyte migration: mediation by highly selective lymphocyte interaction with organ-specific determinants on high endothelia. (nih.gov)
  • Although other proteases with selective cleavage specificity might also contribute to the MHC class I peptide pool, this seems to apply only for a limited subset of peptides and cannot substitute for proteasome function ( 7 ). (rupress.org)
  • Our experiments demonstrate that 20S proteasomes of different organs display a characteristic composition of α and β chain subunits and produce distinct peptide fragments with respect to both quality and quantity. (rupress.org)
  • Further, we demonstrate that the organ-specific potential to produce defined T cell epitopes reflects quantities that are relevant for cytotoxic T lymphocyte recognition. (rupress.org)
  • Morphological organ alterations and infectious diseases in brown trout Salmo trutta and rainbow trout Oncorhynchus mykiss exposed to polluted river water. (biomedsearch.com)
  • Compared with the reference group, high mortality rates and severe pathological alterations of the inner organs were observed in fish held in river water. (biomedsearch.com)
  • Understanding the specificity and functional significance of GPCR heterodimerization is of tremendous clinical importance since GPCRs are the molecular targets for numerous therapeutic drugs. (aspetjournals.org)
  • This review will focus on the current state of research on GPCR heterodimerization, with an emphasis on the specificity of these interactions and their functional significance. (aspetjournals.org)
  • The steps to go from a decellularized ECM scaffold to a functional organ is under the umbrella of recellularization. (wikipedia.org)
  • Although the outer structures of bilaterians appear bilaterally symmetric, their internal organs are often LR asymmetric in morphology and positioning. (elifesciences.org)
  • Multiple organ failure (MOF) has a higher mortality rate than OF [ 2 ]. (hindawi.com)
  • In addition, clv1 mutants enhance many of the Bam − organ phenotypes, indicating that, contrary to current understanding, CLV1 function is not specific to the meristem. (genetics.org)
  • Spectra were compared among agents grouped according to target-organ specificity. (epa.gov)
  • To characterise at molecular, cellular and pathophysiological level how Listeria interact with target organs. (europa.eu)
  • Action on target organs gives humane euthanasia of unparalleled speed, effectiveness and specificity. (drugs.com)