Organ Specificity

Kidney

Liver

Sensitivity and Specificity

Substrate Specificity

Antibody Specificity

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Macrophages

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Tissue-Specific Protein Extracts

Tissue-Specific Protein Extracts

TP53TG3 - bs-7701R | acris-antibodies.com

Ruth Clayton

Decellularization

Helicobacter

Lymphocyte homing receptor

Urinary cell-free DNA

Viral neuronal tracing

Autoimmune pancreatitis

CD36

Pseudotropine acyltransferase

O-Acylpseudotropine

Tropine acyltransferase

Nosophobia

Teratoma

MedDRA

BRCA2

CT scan

Clonal selection

History and naming of human leukocyte antigens

Acholeplasmataceae

Cell signaling

Pertechnetate

Adenomyosis

Corethrellidae

Organ bath

Ethanol metabolism

Drug action

Pain theories

Rheumatoid factor

C11orf42

Fungus pocket

Norovirus

Clonal deletion

Sexual anomalies

Selective androgen receptor modulator

Choriaster

COVID-19

Placental alpha microglobulin-1 (PAMG-1)

Rectal examination

Dementia with Lewy bodies

Bioluminescence

Chronic cerebrospinal venous insufficiency controversy

Appendicitis

Binding selectivity

Free will

Prostate cancer

DNA damage theory of aging

Pheochromocytoma

Bovine spongiform encephalopathy

Alkaline phosphatase

Șerban Cioculescu

CAAT box

Aldolase A

Homeobox protein SIX1

Neuroimmunology

Angelicin

Zinc in biology

NUMB (gene)

Reverse phase protein lysate microarray

Function-spacer-lipid Kode construct

Pseudorhabdosynochus youngi

Sensitivity and specifi2

• Optimal case definitions also need to have a balance of sensitivity and specificity that reflects their intended use. (who.int)
• This prompted improvements in the sensitivity and specificity of the case definition for influenza - i.e. a respiratory disease that lacks uniquely defining symptomology. (who.int)

Antibody6

• Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
• In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
• A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)
• Immucor products enable us to accurately assign HLA antibody specificities for better transplant outcomes! (immucor.com)
• The variables that can currently be queried from the Dashboard of integrated registries include: gender, ANCA antibody specificity, organ involvement profile, remission induction treatment, baseline creatinine level, deaths, whether the patient developed end-stage renal disease and treatment complications. (fairvasc.eu)
• The specificity of the antibody was verified by overexpressing full length DUOXA1 in 293T cells and by immunostaining performed on main myoblasts in the absence or presence of the antigenic peptide (Additional file 1 Physique S1A-D). The Balaglitazone antibody was also verified using the immortalized C2C12 myoblast cell collection (Additional file 1 Physique S1E). (researchensemble.com)

Dual-specificity1

• Tian and colleagues report on PET imaging and quantitation with a dual-specificity probe that molecularly targets both CCND1 mRNA and insulinlike growth factor 1 receptor in early breast cancer. (snmjournals.org)

Tissues6

• A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
• This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
• The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
• The altered signaling interferes with the normal development of many organs and tissues, resulting in the characteristic features of cardiofaciocutaneous syndrome. (medlineplus.gov)
• The colonization of intestinal and systemic tissues by Salmonella enterica serovars with different host specificities was determined 7 days after inoculation of 1 to 2-month-old lambs. (moam.info)
• However, sometimes the response to infection may damage the body's own tissues and organs, leading to a life-threatening condition called sepsis. (elifesciences.org)

Tissue10

• This novel technology could shape our molecular understanding of healthy versus diseased tissue, as well as the role that inter-organ communication plays in disease onset and progression. (news-medical.net)
• However, both human and animal studies indicate tissue-specificity of effect. (qub.ac.uk)
• Better understanding of the tissue-specificity of vitamin D-dependent molecular networks may provide insight into selective growth control by the seco-steroid, 1a,25-(OH)2 D3. (qub.ac.uk)
• Because TIEG is an early induced putative transcription factor gene, and shows a growth factor induction and tissue specificity, its protein product might play an important role as a signalling molecule in osteoblastic cells. (elsevier.com)
• Tissue development and organ morphogenesis programs require tight spatial and temporal regulation of gene expression. (biomedcentral.com)
• Modulated through signaling pathways and protein interactions, TFs set up the transcriptional programs that ultimately specify cell fates and coordinate tissue and organ formation. (biomedcentral.com)
• A major challenge in our study was to prepare tissue sections that were compatible with high spatial resolution analysis and therefore dedicated sample preparation protocols were established and optimized for the physicochemical properties of all major plant organs. (rsc.org)
• Fascia is the intricate network of connective tissue embracing each muscle, organ, bone, blood vessel and nerve, binding the body's structures to a marvellous, flexible and interwoven web. (impulstanz.com)
• Endoscopic ultrasound (EUS) is an ideal method for obtaining tissue from submucosal lesions in the gastrointestinal tract or from organs near the gastrointestinal tract. (radiologykey.com)
• The uncontrolled inflammation can damage body tissue and organs, including the gastrointestinal system, joints and skin. (cdc.gov)

Yielded a sensitivity1

• Organisms seen by Gram stain yielded a sensitivity of 96.6%, specificity of 88.9%, positive predictive value of 97.7% and negative predictive value of 84.2% when used to predict positive culture results for bacterial wound infection. (who.int)

Reproducibility2

• How reliable are OC systems (sensitivity, specificity, reproducibility)? (toxicologie.nl)
• In addition, this biosensor exhibited excellent specificity and high reproducibility. (nanotech-now.com)

Genes5

• An organ-specific regulation was assigned to a number of genes previously known to react to a cytokinin signal, including root-specificity for the cytokinin hydroxylase gene CYP735A2 and shoot specificity for the cell cycle regulator gene CDKA;1 . (biomedcentral.com)
• Compared to other genes, TFs are enriched early in the development of most organ systems, and throughout the development of the nervous system. (biomedcentral.com)
• MADS-box genes play crucial roles in plant floral organ formation and plant reproductive development. (biomedcentral.com)
• This strongly corroborates the notion that clades of floral organ identity genes led to the evolution of flower development in flowering plants. (biomedcentral.com)
• In addition, the four clades of floral organ identity genes in both orchids displayed a conservative and divergent expression pattern. (biomedcentral.com)

Transplantation2

• On July 3, 2014, the Organ Procurement and Transplantation Network (OPTN) began overseeing vascularized composite allotransplantation/allografts (VCA) in the United States. (myast.org)
• Equity and utility will be discussed for each organ specifically with specialized tracks, as well as multi-organ transplantation. (healthytransplant.com)

Sequential organ failure assessment5

• The prognostic and diagnostic performance of quick sequential organ failure assessment in dogs with severe sepsis and septic shock has not been evaluated before. (bsava.com)
• The study aim was to evaluate the prognostic utility and performance of a quick sequential organ failure assessment score to diagnose severe sepsis or septic shock in dogs presented to an emergency service. (bsava.com)
• It was found that the quick sequential organ failure assessment score provided poor discrimination between survivors and non-survivors for dogs with severe sepsis and septic shock. (bsava.com)
• Considering the results of this study, it may not be possible to identify a single scoring system that serves the purpose that quick sequential organ failure assessment is intended for. (bsava.com)
• The new definition relies on Sequential Organ Failure Assessment (SOFA) score. (epomedicine.com)

20201

• CEoT 2020 will be an exciting exploration of the hot topic of organ allocation and how the transplant community should consider the balance of equity and utility. (healthytransplant.com)

Molecular2

• For another, studies have shown that many of the health complications that arise from obesity could be due to faulty organ communication, yet many of the molecular mechanisms remain unknown. (news-medical.net)
• 2 ppm root mean square error), for molecular specificity. (rsc.org)

Transplant6

• Roughly 65 years ago, the first human organ transplant was successfully performed. (eurekalert.org)
• Ischemia-reperfusion injury also promotes organ rejection after transplant. (eurekalert.org)
• The startup, Lydex Pharmaceuticals, has received almost $300,000 in small business technology transfer grant funding from the National Institutes of Health to develop a novel approach to preventing reperfusion-related organ damage after liver transplant. (eurekalert.org)
• Because severe fatty livers are especially vulnerable to the damage caused by ischemia reperfusion, they are not currently used for liver transplant, exacerbating the shortage of donor organs. (eurekalert.org)
• For the past 6 years, centers performing VCAs have been requested to submit data into a biometric repository, in parallel with systems used by solid organ transplant centers. (myast.org)
• The overarching goal is to systematically address the issues of organ allocation in order to reframe the discussion and improve the transplant community's ability to move forward toward the future. (healthytransplant.com)

Gene6

• Blood gene expression markers for target organ toxicity. (cdc.gov)
• The purpose of this study was to investigate whether peripheral blood gene expression can be used as non-invasive, surrogate marker(s) to detect and distinguish target organ toxicity. (cdc.gov)
• The blood gene expression markers detected and distinguished hepatotoxicity and neurotoxicity induced by the chemicals with significant accuracy and specificity. (cdc.gov)
• In summary, our results demonstrated that blood gene expression may be used as markers to detect and distinguish target organ toxicity. (cdc.gov)
• It may be assumed that organ-specific regulation of gene expression is involved in these differential activities, but little is known about it. (biomedcentral.com)
• We produced a reference TF dataset for the investigation of gene regulatory networks in embryogenesis, and gained insight into the expression dynamics of the full complement of TFs controlling the development of each organ system. (biomedcentral.com)

Involvement2

• [ 11 ] Because of the high sensitivity of these biomarkers, experts suggest that they be included in the regular follow-up panel for patients with a monoclonal protein and abnormal free light chain ratios, as they may represent the first sign of organ involvement. (medscape.com)
• In patients with such clinically manifest diseases, changes in the nailfold capillaries may reflect internal organ involvement and helps the clinician to determine the stage of the disease. (cdriadvlkn.org)

Diagnostic accuracy2

• Use of a liquid‐based cytologic preparation such as ThinPrep™ or SurePath™, direct smears, core biopsy, or some combination of these methods depends on the lesion, pathologist and endoscopist preference, staffing, location of the endoscopy suite in relation to the laboratory, and the relative sensitivity, specificity, and diagnostic accuracy of the various technical choices. (radiologykey.com)
• Done using MedCalc Version 12.7.5.0 to find out the sensitivity, specificity, and diagnostic accuracy of conventional smears and cell blocks. (jcytol.org)

Multiple organ systems4

• There is a broad differential diagnosis that includes causes arising from multiple organ systems (Table 1), with overlapping signs and symptoms decreasing specificity. (appliedradiology.com)
• Of the 535 TFs with spatially restricted expression, 79% are dynamically expressed in multiple organ systems while 21% show single-organ specificity. (biomedcentral.com)
• Of those expressed in multiple organ systems, 77 TFs are restricted to a single organ system either early or late in development. (biomedcentral.com)
• von Hippel-Lindau (VHL) disease, or von Hippel-Lindau syndrome, is a rare genetic disorder characterized by visceral cysts and benign tumors in multiple organ systems that have subsequent potential for malignant change. (medscape.com)

Gastrointestinal tract1

• NETs are a group of tumors with heterogenous malignancy that evolve from neuroendocrine cells, with the lung being the second target organ after the gastrointestinal tract. (spandidos-publications.com)

Autoimmune1

• Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and non-organ specific autoimmune diseases confers high specificity for insulin- dependent diabetes mellitus. (cdc.gov)

Detect2

• In addition, the quick sequential organ failure score demonstrated a poor sensitivity and fair specificity to detect this population of canine patients. (bsava.com)
• Sensitivity is the ability of a method to detect patients with the disease and specificity is the ability to detect patients without the disease. (novabiomedical.com)

Tumors1

• Tumors involving other organs and the CNS (brain, spinal cord) are present in 25% of patients with VHL disease. (medscape.com)

Species1

• This factor is relatively organ and species-specific. (elsevier.com)

Auditory2

• Here we report significant and progressive degeneration of auditory and vestibular organs that result in complete deafness and balance defects in s1p 2 −/− and s1p 2 −/− / s1p 3 −/− mice. (jneurosci.org)
• Deficits were discovered in peripheral visual and auditory end-organ function, intracerebral auditory and visual processing speed and dichotic listening performance. (frontiersin.org)

Donor1

• One of the worst is the ischemia, or lack of blood supply, that the transplanted organ experiences as it goes from donor to recipient. (eurekalert.org)

Sepsis4

• Sepsis is defined as a syndrome of physiologic, pathologic, and biochemical abnormalities induced by infection which results in life-threatening organ dysfunction caused by dysregulated host response [ 3 ]. (biomedcentral.com)
• Different from those previous diagnostic criteria for sepsis, sepsis-3 highlighted the strong association between infection and organ failure according to the Third International Consensus Definitions for Sepsis and Septic Shock in February 2016 [ 2 ], hence, the early identification and diagnosis for sepsis are essential, which could provide meaningful information for clinicians to assess patients' condition and improve survival outcomes through prompt and appropriate treatment. (biomedcentral.com)
• The new sepsis definitions recommend using a change in baseline of the total SOFA score of two or more points to represent organ dysfunction. (epomedicine.com)
• According to the new guidelines by Sepsis-3 task force in 2016, sepsis is no longer defined by non-specific SIRS criteria and the focus has been shifted to the pathophysiology of host's response and related organ dysfunction. (epomedicine.com)

Fatigue1

• A condition that develops when your blood lacks enough healthy red blood cells which are the main transporters of oxygen to organs causing symptoms like fatigue. (cdc.gov)

Outcomes1

• These outcomes suggest that modifications in either good specificity or additional qualitative aspects may be from the failing of down-regulation of swelling in the coronary arteries [3,5C7]. (forgetmenotinitiative.org)

Systems3

• Our many different organ systems are in constant communication with each other. (news-medical.net)
• My bet would be on coming up with toolkit for identifying the situations in which co-evolution occurs within lmits, as distinct from cases when its non-linearity renders problems obsolete faster than the emergence of solutions: a set of systems co-involuting through a shared Body without Organs, with degrees of stability and relative velocities. (warwick.ac.uk)
• Clinical manifestations of MFS in other organ systems were critically evaluated for their specificity and diagnostic utility based on expert opinion and the available literature. (marfan.org)

Cells of the organ2

• These results support the notion that the early effects of vanadate are on the contra-luminal membranes of cells of the organ of Corti rather than on the stria vascularis. (wustl.edu)
• Without a constant supply of blood, the cells of the organ are cut off from fresh oxygen and nutrients that they need to survive. (eurekalert.org)

Lung2

• Regarding CA IV, the results lead to the conclusion that omeprazole selectively inhibits gastric mucosa CA IV and does not modify the activity of the same isozyme from the kidney and lung, indicating organ specificity. (aspetjournals.org)
• The lung is the second organ, after the liver, in the localization of NETs, making up 25% of all NETs and 1-2% of all cancers ( 9 ). (spandidos-publications.com)

Clinical1

• Because VHL disease is a multiple-organ disease that widely varies in clinical presentation, various manifestations may lead to diagnosis. (medscape.com)

Single organ1

• With this type of model, scientists can start to map unexplored disease pathways and ultimately develop targeted treatments, as many diseases originate in a single organ and then eventually spread to others. (news-medical.net)

Cell3

• To address whether there are organ-specific demands, we implement a novel mononuclear phagocyte subsetting strategy in the murine intestine and found two novel colon-specific mononuclear phagocytes: a macrophage population and a Th17-inducing dendritic cell (DC) subset. (duke.edu)
• We anticipate that the presented MPL-compatible OS composite resins will pave the path towards production of soft, bioactive, and conductive microstructures for various applications in the emerging fields of flexible bioelectronics, biosensors, nanoelectronics, organ-on-chips, and immune cell therapies. (nanotech-now.com)
• Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen. (bvsalud.org)

High1

• displaying the high specificity of the model as well. (news-medical.net)

Plant2

• I am fascinated by the secret chemical language of the symbiotic partners, how this dialogue results in the development of a new plant organ, and how differentiation of the plant cells and the bacteria are coordinated. (balzan.org)
• In addition, different major plant organs and a wide variety of compound classes were analyzed. (rsc.org)

Embryogenesis1

• The first expression design of DUOXA1 (prior to the development of several organs) shows that it may enjoy important jobs in embryogenesis. (researchensemble.com)

Detection1

• Unfortunately, of geographical and temporal variations in prevalence, the ease of use tends to decrease as specificity increases and there detection of the increases in incidence that may be indicative often needs to be a trade-off between the sensitivity of a case of outbreaks and the evaluation of the effectiveness of control definition and its specificity. (who.int)

Inflammation1

• However, sudden reintroduction of blood to the transplanted organ, known as reperfusion, floods cells with oxygen, setting off a chain reaction that leads to the production of free radicals that can trigger inflammation and cause organ damage. (eurekalert.org)

Results1

• The degree of lactate elevation directly correlates with the concentration of glycolate present, and the artifact probably results from the lack of specificity of the lactate oxidase enzyme used in these machines. (umaryland.edu)

Liver1

• The organs most commonly injured with anterior abdominal stab wounds are the small bowel , the liver , and the colon . (medscape.com)

Positive predi1

• concluded that SIRS criteria exhibited a sensitivity of 69%, specificity of 35%, positive predictive value (PPV) of 90%, negative predictive value (NPV) of 12% and positive LR of 1.06. (epomedicine.com)

Identity1

• The shift of the root and shoot transcriptomes towards the respective other organ depending on the cytokinin status indicated that the hormone determines part of the organ-specific transcriptome pattern independent of morphological organ identity. (biomedcentral.com)

Body2

• This contains some fascinating schizoanalysis of theatre and its Body without Organs, biological life. (warwick.ac.uk)
• Thirdly, the article shows that the connection between pain and body is inherent to the specificity of the organ to psychoanalysis. (bvsalud.org)

Patients2

• Determine the qualitative and quantitative toxic effects of this regimen in these patients with regard to organ specificity, time course, predictability, and reversibility. (knowcancer.com)
• Ethylene glycol can result in elevated lactate concentrations secondary to hypotension and organ failure in severely poisoned patients. (umaryland.edu)

Demands1

• between professional competence, The institution is characterized by political decision and the emergence of epistemic specificity in the health field, nursing care demands in Fluminense and develops reflexive and normative society. (bvsalud.org)

Development1

• We generated RNA expression patterns for all 708 TFs by in situ hybridization, annotated the patterns using an anatomical controlled vocabulary, and analyzed TF expression in the context of organ system development. (biomedcentral.com)

Pathophysiology2

• In addition to aiding in dis- covering new pathogens, these techniques also contributed to studies of the epidemiology, pathophysiology, and treatment response of the newly recognized diseases, providing further evidence for causal relationships between disease and organ- ism (1). (cdc.gov)
• COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple organ failure1-4, but little is known about its pathophysiology. (duke.edu)