Organ Size: The measurement of an organ in volume, mass, or heaviness.Plant Components, Aerial: The above-ground plant without the roots.Physalis: A plant genus of the family SOLANACEAE. Members contain physalin and withangulatin.Drosophila Proteins: Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.WingProtein-Serine-Threonine Kinases: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.Intracellular Signaling Peptides and Proteins: Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Arabidopsis Proteins: Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.Gene Expression Regulation, Plant: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.Arabidopsis: A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.Flowers: The reproductive organs of plants.Drosophila: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.Drosophila melanogaster: A species of fruit fly much used in genetics because of the large size of its chromosomes.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Plants, Genetically Modified: PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.Body Size: The physical measurements of a body.Cell Size: The quantity of volume or surface area of CELLS.Meristem: A group of plant cells that are capable of dividing infinitely and whose main function is the production of new growth at the growing tip of a root or stem. (From Concise Dictionary of Biology, 1990)Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Tissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Eye: The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Plant Leaves: Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)Cell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Genes, Plant: The functional hereditary units of PLANTS.Animals, Genetically Modified: ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.Morphogenesis: The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesBody Patterning: The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.Trans-Activators: Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.Basal Metabolism: Heat production, or its measurement, of an organism at the lowest level of cell chemistry in an inactive, awake, fasting state. It may be determined directly by means of a calorimeter or indirectly by calculating the heat production from an analysis of the end products of oxidation within the organism or from the amount of oxygen utilized.Plant Proteins: Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.Seeds: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Multiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.Cell Cycle Proteins: Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.PhosphoproteinsStem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Organ of Corti: The spiral EPITHELIUM containing sensory AUDITORY HAIR CELLS and supporting cells in the cochlea. Organ of Corti, situated on the BASILAR MEMBRANE and overlaid by a gelatinous TECTORIAL MEMBRANE, converts sound-induced mechanical waves to neural impulses to the brain.Organ Specificity: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.Tumor Suppressor Proteins: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Protein Kinases: A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Vomeronasal Organ: An accessory chemoreceptor organ that is separated from the main OLFACTORY MUCOSA. It is situated at the base of nasal septum close to the VOMER and NASAL BONES. It forwards chemical signals (such as PHEROMONES) to the CENTRAL NERVOUS SYSTEM, thus influencing reproductive and social behavior. In humans, most of its structures except the vomeronasal duct undergo regression after birth.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Subfornical Organ: A structure, situated close to the intraventricular foramen, which induces DRINKING BEHAVIOR after stimulation with ANGIOTENSIN II.Pelvic Organ Prolapse: Abnormal descent of a pelvic organ resulting in the protrusion of the organ beyond its normal anatomical confines. Symptoms often include vaginal discomfort, DYSPAREUNIA; URINARY STRESS INCONTINENCE; and FECAL INCONTINENCE.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Tissue and Organ Harvesting: The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.Brain Death: A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Enamel Organ: Epithelial cells surrounding the dental papilla and differentiated into three layers: the inner enamel epithelium, consisting of ameloblasts which eventually form the enamel, and the enamel pulp and external enamel epithelium, both of which atrophy and disappear before and upon eruption of the tooth, respectively.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Animal Structures: Organs and other anatomical structures of non-human vertebrate and invertebrate animals.

Decreased liver and lung drug-metabolizing activity in mice treated with Corynebacterium parvum. (1/12866)

Injections of killed suspensions of Corynebacterium parvum (i.p.) in young male mice were followed by time- and dose-dependent decreases in the drug-metabolizing activity of liver microsomes and lung homogenates. In vitro assays with model substrates [aminopyrine, aniline, p-nitroanisole, and benzo(a)pyrene] were used to quantitate drug-metabolizing activity. It is likely that such decreases in mixed function oxidases activity will act to significantly alter the pharmacokinetics of concurrently or subsequently administered drugs. The results provide a possible mechanism to explain several previously reported immunochemotherapeutic interactions.  (+info)

Ambiguity of the thymidine index. (2/12866)

The observed thymidine indices of seven experimental tumor lines are compared as a function of duration of emulsion exposure. The effects of dose level of tritiated thymidine and background threshold are also evaluated. The results indicate that an arbitrary high background threshold discriminates against "lightly" labeled cells at short periods of exposure but that the chosen threshold becomes less critical with longer exposure. The observed thymidine index increases with increasing duration of emulsion exposure but appears to approach a plateau for all tumor systems. The "thymidine index curves" are significantly different for each tumor. There is an inverse relationship between the dose of tritiated thymidine and the duration of exposure required to recognize the same fraction of cells as labeled in a given tumor. Similar experimental conditions do not necessarily guarantee a valid basis for comparison of observed thymidine indices among tumors.  (+info)

The developmental basis for allometry in insects. (3/12866)

Within all species of animals, the size of each organ bears a specific relationship to overall body size. These patterns of organ size relative to total body size are called static allometry and have enchanted biologists for centuries, yet the mechanisms generating these patterns have attracted little experimental study. We review recent and older work on holometabolous insect development that sheds light on these mechanisms. In insects, static allometry can be divided into at least two processes: (1) the autonomous specification of organ identity, perhaps including the approximate size of the organ, and (2) the determination of the final size of organs based on total body size. We present three models to explain the second process: (1) all organs autonomously absorb nutrients and grow at organ-specific rates, (2) a centralized system measures a close correlate of total body size and distributes this information to all organs, and (3) autonomous organ growth is combined with feedback between growing organs to modulate final sizes. We provide evidence supporting models 2 and 3 and also suggest that hormones are the messengers of size information. Advances in our understanding of the mechanisms of allometry will come through the integrated study of whole tissues using techniques from development, genetics, endocrinology and population biology.  (+info)

Lung weight parallels disease severity in experimental coccidioidomycosis. (4/12866)

Evidence provided by histopathological study of lesions is a valuable adjunct for evaluating chemotherapeutic efficacy in experimental animal models, In addition, this should be correlated with a measure of disease severity in the same animal. The latter could be obtained by homogenization of infected organs and quantitative enumeration of viable cells of the etiological agent, but this would preclude histopathological studies in the same animal. Progression of disease in pulmonary infection is associated with replacement of air space by fluid, cells, and cellular debris. Therefore, an increase in lung weight should reflect severity of disease. Results with the murine model of coccidioidomycosis demonstrate that increasing lung weight parallels the increasing census of fungus cells in the lungs of both treated and nontreated infected mice. This was supported with evidence obtained from microscopic studies of lesions indicating that specific chemotherapy limited spread of the infection and inhibited multiplication of the fungus in the lung. Therefore, lung weight can be used as a measure of disease severity in the murine model of coccidioidomycosis.  (+info)

Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection. (5/12866)

The long-term administration of L-carnitine was very effective in preventing cardiomegaly in juvenile visceral steatosis (JVS) mice, which was confirmed by heart weight as well as the lipid contents in heart tissue. After i.p. injection of L-carnitine, the concentration of free carnitine in heart remained constant, although serum free carnitine level increased up to 80-fold. On the other hand, a significant increase in short-chain acyl-carnitine level in heart was observed. These results suggest that increased levels of short-chain acyl-carnitine, not free carnitine, might be a key compound in the protective effect of L-carnitine administration in JVS mice.  (+info)

Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. (6/12866)

Uncoupling protein 2 (UCP2) uncouples respiration from oxidative phosphorylation and may contribute to obesity through effects on energy metabolism. Because basal metabolic rate is decreased in obesity, UCP2 expression is predicted to be reduced. Paradoxically, hepatic expression of UCP2 mRNA is increased in genetically obese (ob/ob) mice. In situ hybridization and immunohistochemical analysis of ob/ob livers demonstrate that UCP2 mRNA and protein expression are increased in hepatocytes, which do not express UCP2 in lean mice. Mitochondria isolated from ob/ob livers exhibit an increased rate of H+ leak which partially dissipates the mitochondrial membrane potential when the rate of electron transport is suppressed. In addition, hepatic ATP stores are reduced and these livers are more vulnerable to necrosis after transient hepatic ischemia. Hence, hepatocytes adapt to obesity by up-regulating UCP2. However, because this decreases the efficiency of energy trapping, the cells become vulnerable to ATP depletion when energy needs increase acutely.  (+info)

Modulation of oestrogenic effects by progesterone antagonists in the rat uterus. (7/12866)

Antiprogestins can modulate oestrogenic effects in various oestrogen-dependent tissues, dependent on species, tissue, dose and duration of treatment. Enhanced oestrogenic responses to mifepristone and onapristone occur in vitro and in vivo. However, the antiprogestins mifepristone, onapristone, and ZK 137 316 can block the ability of oestradiol to increase endometrial growth in non-human primates. Our purposes were firstly, to decide whether mifepristone and onapristone had direct oestrogenic activity in vitro and in the uterus of spayed and immature rats, and secondly, to discover whether antiprogestins exhibit inhibitory effects on oestrogen action in the uterus in spayed, oestrogen-substituted rats. In transactivation assays, mifepristone induced oestrogenic response, whereas onapristone had only marginal effects on reporter gene transcription. In immature rats, onapristone and mifepristone markedly increased uterine weights, and onapristone, but not mifepristone significantly enhanced endometrial luminal epithelial height, a sensitive oestrogen parameter. Conversely, in spayed and adrenalectomized rats, neither onapristone nor mifepristone changed uterine weights or endometrial morphology, indicating that their effects in immature rats were indirect. In spayed, oestrogen-substituted rats, antiprogestins did not block oestradiol-stimulated endometrial growth and luminal and glandular epithelium were stimulated more after antiprogestin plus oestrogen, than after oestradiol alone. All compounds induced compaction of the uterine stroma. In spayed rats, onapristone and some other 13alpha-configured (type 1) antagonists (ZK 135 569, ZK 131 535) reduced oestradiol-stimulated myometrial proliferation and induced an overall uterine weight reduction in animals treated with oestrogen and antiprogestins, in comparison with oestradiol-treated controls. 13beta- configured (type II) antagonists, including mifepristone, lilopristone and ZK 112 993, were not effective. In the uteri of spayed rats, onapristone was also found to enhance the oestradiol-stimulatory effect on expression of the oestrogen-dependent proto-oncogene, c-fos. In conclusion, antiprogestins do not inhibit, but rather enhance, oestrogen-induced uterine glandular and luminal epithelium in spayed rats, contrary to their effects in primates. The rat model is unsuitable to study endometrial antiproliferative effects of antiprogestins in primate uteri.  (+info)

Investigation of distal aortic compliance and vasodilator responsiveness in heart failure due to proximal aortic stenosis in the guinea pig. (8/12866)

Hypotension and syncope are recognized features of chronic aortic stenosis. This study examined vasomotor responses and dynamic compliance in isolated abdominal aortae after chronic constriction of the ascending aorta. Guinea pigs underwent constriction of the ascending aorta or sham operation. Sections of descending aorta were removed for studies of contractile performance and compliance. Dynamic compliance was measured using a feedback-controlled pulsatile pressure system at frequencies of 0.5, 1.5 and 2.5 Hz and mean pressures from 40 to 100 mmHg. Chronic (149+/-6 days) aortic constriction resulted in significant increases in organ weight/body weight ratios for left ventricle (58%), right ventricle (100%) and lung (61%). The presence of heart failure was indicated by increased lung weights, left ventricular end-diastolic pressure and systemic vascular resistance, reduced cardiac output and increased levels of plasma atrial natriuretic peptide (166%), adrenaline (x20), noradrenaline (106%) and dopamine (x3). Aortic rings showed similar constrictor responses to phenylephrine and angiotensin II, but maximal vasodilator responses to acetylcholine and isoprenaline were significantly increased (144% and 48% respectively). Dilator responses to sodium nitroprusside, forskolin and cromokalim were unchanged. Compliance of all vessels decreased with increasing pulsatile frequency and to a lesser extent with increased mean pressure, but were similar in aortic-constricted and control groups. Chronic constriction of the ascending aorta resulted in heart failure and increased vasodilator responses to acetylcholine and isoprenaline in the distal aorta while dynamic compliance was unchanged. We hypothesize that increased endothelium-mediated vasodilatation may contribute to hypotension and syncope in patients with left ventricular outflow obstruction.  (+info)

  • The past several years have seen surprising improvements in the development of in vitro organs and tissues model with various purposes based on microfluidic devices known as organ on chip. (researchandmarkets.com)
  • A main goal of regenerative medicine is to replace lost or damaged tissues and organs with functional parts of the correct size and shape. (biologists.org)
  • For regenerative medicine, which aims to replace lost or damaged organs and limbs, elucidating these mechanisms is crucial because the production of new cells is not sufficient - new tissues must be the correct size and shape to restore form and function. (biologists.org)
  • Here, we identified and characterized OseIF3e in rice ( Oryza sativa L.). OseIF3e was constitutively expressed in various tissues, but most strongly in vigorously growing organs. (frontiersin.org)
  • Organ on chip creates new and innovative ways to culture cells and tissues which offer precise and continuous control during complete culturing process. (futuremarketinsights.com)
  • They found that when the default option was to not be an organ donor - that is, if the participants of the experiment had to change a selection from being 'not a donor' to 'donor'- only 42% of people opted to do so. (thersa.org)
  • Nor will they make the choice mandatory, so that, for example, when you log in to your Facebook account you would be met with the question of whether or not you'd like to be an organ donor, and are only allowed to use Facebook once a selection has been made. (thersa.org)
  • The campaign made it easy for people to not only register to be a donor, but also - and more importantly for social contagion - to list their organ donor status on their profile and spread the word through the Facebook newsfeed. (thersa.org)
  • Worldwide, there is a huge gap between organ donor and organ receiver. (brandessenceresearch.com)
  • Numbers of organ donor are very less in number as compared to organ receiver. (brandessenceresearch.com)
  • The largest possible height commonly obtainable is 95 for a Tall Giant Kaiju with a Tormunga torso, Giant Size toggle on, and the Overblown and Large Tendencies perks. (flexiblesurvival.com)
  • Midday Music for Organ on Wednesday, October 18th, 2017 presents Michael Plagerman, our newest member of the doctoral program in performance practice. (cornell.edu)
  • Collective efforts of governments to launch universal health coverage schemes and increasing awareness about public and private reimbursement policy coverages are some trends expected to boost adoption rates and create opportunities for players in the global artificial vital organs and medical bionics market during the forecast period. (pharmiweb.com)
  • The global Organ Preservation Solution market report is a comprehensive research that focuses on the overall consumption structure, development trends, sales models and sales of top countries in the global Organ Preservation Solution market. (marketstudyreport.com)
  • The report titled "Pelvic Organ Prolapse Repair Device Market: Global Industry Size, Share, Market Trends, Competitive Analysis and Forecast - 2019-2025", recently published by Credence Reports covering global market size for pelvic organ prolapse repair device market for the key segments and further cross-regional segmentation of these segments for the period 2019 to 2025. (credencereports.com)
  • According to Credence Reports, this study will provide in-depth analysis of segments on the basis of current trends, market dynamics and country level analysis of pelvic organ prolapse repair device industry. (credencereports.com)
  • The quantitative and qualitative analysis is provided for the global market considering competitive landscape, development trends, and key critical success factors (CSFs) prevailing in the pelvic organ prolapse repair device industry. (credencereports.com)
  • The Advanced Tissue-engineered Human Ectypal Network Analyzer ( ATHENA ) project has created interconnected, surrogate human organs, researchers said in a new video. (fcw.com)
  • Gift of Hope is opening a 48,000-square-foot community development hub in Chatham that will include employee offices, shared workspaces for nonprofits and a job training center for recent high school graduates.The Itasca-based organ and tissue donation network paid $1.2 million for the three-story building at 7936 S. Cottage Grove Avenue, which was previously home to Urban Partnership Bank. (chicagobusiness.com)
  • But despite the importance of tissue remodeling, we do not yet understand the mechanisms that coordinate individual cell regulatory pathways into tissue- and organ-level organization. (biologists.org)
  • Furthermore, mechanical cues do not only regulate processes at a cellular level but also provide constant feedback about size and shape on a tissue scale. (uzh.ch)
  • The market of organ and tissue replacement can be divided in to various parts, such as tissue typing technology, solid organ procurement and preservation, tissue products, immunosuppressant, post translational monitoring of tissue and organ and alternative devices and technologies. (transparencymarketresearch.com)
  • In addition, the device can cause the tearing of the male organ tissue, something that is not worth the risk. (viagramasculina.info)
  • Not only does the pump use not permanently increase the size, but long or frequent use can actually damage the elastic tissue within the male organ required for strong immune system. (viagramasculina.info)
  • Artificial organs are mechanically or electronically engineered device and tissue, which are used to integrate into the human body to interface with living tissue or to replace with damaged organs or to augment specific organs function. (brandessenceresearch.com)
  • The tissue consists of around 100,000 lobules and is metabolically the most complex human internal organ. (adducation.info)
  • Significant regressions between organ number and corresponding meristem size were consistent with the premise that a larger meristem size prior to organ initiation could be determining for a higher organ number. (springer.com)
  • Exogenous application of the peptides FON4p and CLV3p corresponding to the CLV3/ESR-related (CLE) motifs of FON4 and CLV3, respectively, resulted in termination of SAMs in rice, and treatment with CLV3p caused consumption of both rice and Arabidopsis root meristems, suggesting that the CLV pathway in limiting meristem size is conserved in both rice and Arabidopsis. (plantphysiol.org)
  • While klu loss-of-function mutants form smaller organs because of a premature arrest of cell proliferation, KLU overexpression leads to larger organs with more cells. (nih.gov)
  • The expression dynamics of KLU suggest a model of how the arrest of cell proliferation is coupled to the attainment of a certain primordium size, implying a common principle of size measurement in plants and animals. (nih.gov)
  • These results indicate that cell proliferation and cell expansion are coordinated through multiple pathways during leaf size determination. (frontiersin.org)
  • Therefore, quantitative recognition of size-related parameters and developmental decisions is required to control the kinetic aspects of cell proliferation and cell expansion. (frontiersin.org)
  • In addition to such cell level regulation, cell proliferation and postmitotic cell expansion must be coordinated to establish an organ of the appropriate size. (frontiersin.org)
  • Moreover, morphological and cytological analysis of triple and quadruple osr mutants verified that the four OSR members differentially but cooperatively participate in the regulation of cell proliferation and cell expansion and thus the final organ size. (biomedcentral.com)
  • Kegel exercises are exercises that anyone can do to recover loss of strength in pelvic floor - a hammock of muscles that keep our organs in. (lelo.com)
  • Objective To compare the effects of pelvic floor muscle training and watchful waiting on pelvic floor symptoms in a primary care population of women aged 55 years and over with symptomatic mild pelvic organ prolapse. (bmj.com)
  • Exclusion criteria were current prolapse treatment or treatment in the previous year, malignancy of pelvic organs, current treatment for another gynaecological disorder, severe/terminal illness, impaired mobility, cognitive impairment, and insufficient command of the Dutch language. (bmj.com)
  • Pelvic organ prolapse is a common condition characterised by descent of the anterior or posterior vaginal wall, the uterus, or the vaginal vault (after hysterectomy). (bmj.com)
  • Pelvic organ prolapse (POP) refers to a condition in which one or more of the pelvic organs suffers descent from their normal position in the pelvis. (news-medical.net)
  • This leads to a widening of the gaps through which the pelvic organs communicate with the outside. (news-medical.net)
  • Retrieved on February 21, 2020 from https://www.news-medical.net/health/Types-of-Pelvic-Organ-Prolapse.aspx. (news-medical.net)
  • The global pelvic organ prolapse repair device market size is estimated to grow at significant CAGR during the forecast period. (credencereports.com)
  • The pelvic organ prolapse repair device market report offers a primary overview of the pelvic organ prolapse repair device industry covering different product definitions, classifications, and participants in the industry chain structure. (credencereports.com)
  • Which manufacturer/vendor/provider in the pelvic organ prolapse repair device industry was the market leader in 2018? (credencereports.com)
  • Stem cells within a small central zone of the shoot apical meristem (SAM) have the ability to grow and divide to replace cells of the SAM flanks, which then drive the formation of lateral organs. (plantphysiol.org)
  • Thoroughly clean and rinse the member daily and use a specially formulated male organ health creme (health professionals recommend Man 1 Man Oil, which has been clinically proven safe and mild for skin) to sport the most smooth, supple member a woman has ever handled. (zuarticles.com)
  • Visit http://www.menshealthfirst.com for additional information on most common male organ health issues, tips on improving sensitivity and what to do to maintain a healthy member. (zuarticles.com)
  • People can also consider buying crème male organ health (health professionals recommend Man1 Man Oil) to better protect themselves from upset. (viagramasculina.info)
  • Even acknowledging that male organ health and skill with one's equipment ultimately matters more than mere male organ size, most men still would like to sport an obviously impressive member. (articlecatalog.com)
  • Using a male organ pump in search of greater male organ size may cause soreness, so regular application apply a first-rate male organ health oil (health professionals recommend Man 1 Man Oil, which is clinically proven mild and safe for skin) is advised. (articlecatalog.com)
  • Want to Maintain Male Organ Health? (doczz.net)
  • Sensual tips can impact male organ health - and that's something good for any season. (doczz.net)
  • It helps if the member is in good shape, so guys must use a first class male organ health creme (health professionals recommend Man 1 Man Oil , which is clinically proven mild and safe for skin) . (zordis.com)
  • When considering the mechanisms of organ size, two contrasting theories exist. (frontiersin.org)
  • By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," Rashi Iyer, a senior scientist at Los Alamos, said in a statement. (fcw.com)
  • The human heart pumps blood at a rate of 60 to 100 beats per minute through the 60,000 miles of blood vessels packed in your body, delivering oxygen and nutrients to your organs and cells. (giantmicrobes.com)
  • In the Renaissance period, Leonardo da Vinci, in his famous picture of the "Vitruvian man", reflects the importance of the size of the human beings and of the organs it holds. (healthcanal.com)
  • Organ on chip is a recently developed multidisciplinary field in which human cell biology and microfluidic are combined on top of lab on chip architecture. (futuremarketinsights.com)
  • Multiple organs can be placed on the chip and re interconnected to model the dynamics of human organism which is possible due to 3D cell culture, micro fluids and 3D printing technologies which allow the cultivation of cells from patients which reflects phenotype or genotype. (futuremarketinsights.com)
  • In the long term, the organ on a chip technology helps in the advanced human based and personalized research and development of drugs. (futuremarketinsights.com)
  • A recipient required an organ to be donated by another living or dead human being. (pharmiweb.com)
  • Many of the studies looked at characteristics like BMI, foot size, index finger length, and testicle size as they related to penis length.The human penis is an external male intromittent organ that additionally serves as the urinal duct. (3at4u1.tk)
  • Data on organ weights in human dwarfs seem to be entirely lacking. (docme.ru)
  • Artificial organs are unnatural machines or devices that substitute various human organs that suffer from the loss or malfunctioning of entire functioning ability. (fiormarkets.com)
  • Artificial organs are made from human stem cells and later grown in laboratories. (fiormarkets.com)
  • Artificial organs are human-made engineered devices that can imitate the necessary organ functions of the body. (fiormarkets.com)
  • Artificial organs are man-made devices which are integrated into human body to replace the natural organs which are either partially or completely not performing its functions at all. (marketdataforecast.com)
  • The debate at least suggesting, that both male and female human reproductive health are affected by Brunström, ), the reproductive organ system (Toppari, ) or the gametes (Perrault Epithelial cell height (Figure 2). (mostformen.com)
  • Currently, the largest size a player can get normally is hardcapped at 20 ( roughly two to three times human average in height, about three to four times human average in mass), while the Kaiju and Quetzalcoatl supernatural dedications allow a larger size bounded by two softcaps. (flexiblesurvival.com)
  • Shows a three-dimensional model of the human body organs and a description of all of them. (apple.com)
  • Zincum Metallicum: this homeopathic ingredient increases the elemental zinc and helps to improve the semen quality and sperm count.Human Anatomy line icon set with female sex organ, heart organ and lips Testosterone effects Infographic image isolated on a light blue background.How ever the size of the vagina increases after child birth, and during sex due to the elasticity of the vaginal muscle. (cameraauctions.tk)
  • Human penis size is described by length and circumference of penis. (cameraauctions.tk)
  • The male reproductive system consists of a number of sex organs that play a role in the process of human reproduction. (cameraauctions.tk)
  • Sortable list of the largest organs of the human body. (adducation.info)
  • We've included a few human body parts which are not human organs (greyed out) to make size comparison easier. (adducation.info)
  • Click column headings with arrows to sort all organs of the human body. (adducation.info)
  • At up to 1.95 square meters (21 sq ft) the skin is the largest of all organs of the human body weighing between 6-10% of body weight. (adducation.info)
  • The ' Cold Chain Logistics Market for Healthcare: Focus on Cell Therapies, Vaccines, and Human Organs, 2018-2030 ' report features an extensive study of the current landscape and future outlook of the growing cold chain logistics services market. (rootsanalysis.com)
  • An analysis comparing the logistical complexities associated with cell therapies, vaccines and human organs, based on several parameters, such as holding temperatures, delivery time restrictions, handling / transportation requirements, and storage related needs. (rootsanalysis.com)
  • Compared with feeding infants breast milk or cow-milk formula, soy formula feeding does not affect subsequent reproductive organ size at 5 years of. (nih.gov)
  • 12/26/ · Male reproductive organ size? (mostformen.com)
  • Learn how to increase male organ size and your stamina that will give you power and a bigger penis head, length and a much larger penis size that you will be proud of. (cameraauctions.tk)
  • Bull-Hereñu K, Ronse de Craene L, Pérez F (2016) Flower meristematic size correlates with heterostylous morphs in two Chilean Oxalis (Oxalidaceae) species. (springer.com)
  • Many men are looking for ways to enhance their sexual performance.When you stop using these capsules, the Male organ returns to its normal size.This can include improving existing problems or searching for new ways to keep your partner happy.For many men, insecurities about penis size and girth can wreak havoc on a love life or sexual relationship. (3at4u1.tk)
  • To increase penis size and girth we recommend using natural penis exercises. (cameraauctions.tk)
  • Based on the preservation solution segment, U.W. (University of Wisconsin) is widely used as it is capable to preserve the organs for a longer period of time than other solutions it is also known as a gold standard of organ preservation techniques. (reportsanddata.com)
  • By technique, the global organ preservation segment is divided into static cold storage, hypothermic perfusion preservation, normothermic machine perfusion, and others. (datamintelligence.com)
  • In now well-known research by Dan Goldstein and Eric Johnson (described by Thaler and Sunstein in Nudge, by Dan Ariely in one of his brilliant TED talks , and used in nearly any conversation about defaults), the authors show that default options matter - a lot - for organ donation rates. (thersa.org)
  • A debossed message for Organ Donation on a 100% silicon rubber wristband, individually packaged, and available now for same day shipping. (supportstore.com)
  • Does Vagina Size Matter? (lelo.com)
  • For this reason, the size of a penis (and of a vagina) count for a lot less than we think, because in reality the vagina adapts to accommodate the anatomy of the penis (or sex toy or what have you). (lelo.com)
  • But these fears are absolutely unfounded: the vagina is an elastic organ, which regains its original form over time - just a few hours after sex and few months after childbirth. (lelo.com)
  • How to increase penis size in hindi naturally at home tips home remedies exercise fast:- The language of this video is Hindi.You may think that 1 inch or 2 inch is small for insertion of male genital organ, but it can accommodate most of the size of male penis due to the lubrication of the vagina during sex and due the elastic nature of the vagina. (cameraauctions.tk)
  • Weighing in at about 10 ounces, an adult heart is about the size of your fist and consists of four chambers: the right atrium, right ventricle, left atrium, and left ventricle. (giantmicrobes.com)
  • X-ray projections from different angles, CBCT scans, and neuro-interventional procedures were simulated on a computational head phantom for the range of head sizes in the adult population and for different pediatric ages. (spie.org)
  • At least 5 dwarf types in the rabbit have been described by Sawin ( '55)' all of which appear to be transmitted by single mutated genes, each inducing a slightly different syndrome of manifestations, but none of these have been studied with reference to their effects upon adult organ size. (docme.ru)
  • Included in the group of 100 adult rabbits of race X (Latimer and Sawin, '55b), there were 15 males and 20 females carrying a single dose of the dwarf gene (Dw), and this explains to a degree the variability observed in this THE DWARF GENE AND ORGAN WEIGHTS 449 race. (docme.ru)
  • Subjects and methods: By using ultrasound, we studied the sizes (absolute and corrected by height, weight and BSA) of the intra-abdominal organs of 18 adult subjects with IGHD (eight females, IGHD group) who have never received GH replacement therapy. (elsevier.com)
  • Most adults find the "Adult 8" size is best. (supportstore.com)
  • what is normal penis size for indian adult? (cameraauctions.tk)
  • As a result, the size of mouse pancreas generated in rat was rat size (about ten times larger than mouse pancreas). (nii.ac.jp)
Testing an Organ System
Testing an Organ System (uen.org)
The constructal law of design and evolution in nature | Philosophical Transactions of the Royal Society B: Biological Sciences
The constructal law of design and evolution in nature | Philosophical Transactions of the Royal Society B: Biological Sciences (rstb.royalsocietypublishing.org)
Types of Pelvic Organ Prolapse
Types of Pelvic Organ Prolapse (news-medical.net)
June 1922 - Scientific American
June 1922 - Scientific American (scientificamerican.com)
P53 determines organ size - Healthcanal.com : Healthcanal.com
P53 determines organ size - Healthcanal.com : Healthcanal.com (healthcanal.com)
Chord Organ + KinderKlavier Bundle on the App Store
Chord Organ + KinderKlavier Bundle on the App Store (itunes.apple.com)
GC322MF Zadar Sea Organ (Traditional Cache) in Croatia created by donweb
GC322MF Zadar Sea Organ (Traditional Cache) in Croatia created by donweb (geocaching.com)
Social regulation of a rudimentary organ generates complex worker-caste systems in ants | Nature
Social regulation of a rudimentary organ generates complex worker-caste systems in ants | Nature (nature.com)
Inhibition of miR-154 Protects Against Cardiac Dysfunction and Fibrosis in a Mouse Model of Pressure Overload | Scientific...
Inhibition of miR-154 Protects Against Cardiac Dysfunction and Fibrosis in a Mouse Model of Pressure Overload | Scientific... (nature.com)
Lakmé - Flowers Duet - Trumpets & Organ by Léo DELIBES (eBook) - Lulu
Lakmé - Flowers Duet - Trumpets & Organ by Léo DELIBES (eBook) - Lulu (lulu.com)
Lean Body Mass as a Predictor of Drug Dosage | SpringerLink
Lean Body Mass as a Predictor of Drug Dosage | SpringerLink (link.springer.com)
Little Organ Book - Volume 3 by Jean-Paul VERPEAUX (eBook) - Lulu
Little Organ Book - Volume 3 by Jean-Paul VERPEAUX (eBook) - Lulu (lulu.com)
Wagner Ride of the Valkyries Organ Transcription by Eugenio Maria Fagiani (eBook) - Lulu
Wagner Ride of the Valkyries Organ Transcription by Eugenio Maria Fagiani (eBook) - Lulu (lulu.com)
Suite Bwv 816 - Gavotte -  Trompette et Orgue / Trumpet & Organ by Johann Sebastian BACH (eBook) - Lulu
Suite Bwv 816 - Gavotte - Trompette et Orgue / Trumpet & Organ by Johann Sebastian BACH (eBook) - Lulu (lulu.com)
Duetto 'Gesegnete Christen' - Cantate BWV184 - Trompette et Orgue / Trumpet & Organ by Johann Sebastian BACH (eBook) - Lulu
Duetto 'Gesegnete Christen' - Cantate BWV184 - Trompette et Orgue / Trumpet & Organ by Johann Sebastian BACH (eBook) - Lulu (lulu.com)
CDC: New Report of Hepatitis C From Donor Organ  - Health Blog - WSJ
CDC: New Report of Hepatitis C From Donor Organ - Health Blog - WSJ (blogs.wsj.com)
A Downside of Organ Donation - WSJ
A Downside of Organ Donation - WSJ (wsj.com)
He's Peddling the Organ to a New Generation - WSJ
He's Peddling the Organ to a New Generation - WSJ (wsj.com)
Human Healthy Medicine Drug Treatment Stomach Internal Digestion Organ Low Poly Connected Dots Gray White Triangle Future...
Human Healthy Medicine Drug Treatment Stomach Internal Digestion Organ Low Poly Connected Dots Gray White Triangle Future... (istockphoto.com)
Postlude on 'Adeste Fideles' for Organ by Marko Hakanpää (eBook) - Lulu
Postlude on 'Adeste Fideles' for Organ by Marko Hakanpää (eBook) - Lulu (lulu.com)
Mobile technologies landscape and opportunity for civil society organ… - English
Mobile technologies landscape and opportunity for civil society organ… - English (slideshare.net)
Paul's Organ Project
Paul's Organ Project (angelfire.com)
Global Life Sciences BPO Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019
Global Life Sciences BPO Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 (prweb.com)
Mediterranean sperm whales show great size variation | EurekAlert! Science News
Mediterranean sperm whales show great size variation | EurekAlert! Science News (eurekalert.org)
Colon Organ Anatomy stock photo | iStock
Colon Organ Anatomy stock photo | iStock (istockphoto.com)
Color organ presentation
Color organ presentation (slideshare.net)
Dirk Inzé Lab
Dirk Inzé Lab (psb.ugent.be)
The Amazing National Monument Organ Pipe Cactus stock photo | iStock
The Amazing National Monument Organ Pipe Cactus stock photo | iStock (istockphoto.com)
Aria 'Wie freudig ist mein Herz' - BWV199 - Trompette, 2 Flûtes & Orgue / Trumpet, 2 Flutes & Organ by Johann Sebastian BACH ...
Aria 'Wie freudig ist mein Herz' - BWV199 - Trompette, 2 Flûtes & Orgue / Trumpet, 2 Flutes & Organ by Johann Sebastian BACH ... (lulu.com)
Frontiers | MADS-Box Genes and Gibberellins Regulate Bolting in Lettuce (Lactuca sativa L.) | Plant Science
Frontiers | MADS-Box Genes and Gibberellins Regulate Bolting in Lettuce (Lactuca sativa L.) | Plant Science (frontiersin.org)
Structural flexibility of the small intestine and liver of garter snakes in response to feeding and fasting | Journal of...
Structural flexibility of the small intestine and liver of garter snakes in response to feeding and fasting | Journal of... (jeb.biologists.org)