Organ Preservation
Organ Preservation Solutions
Raffinose
Laryngeal Neoplasms
Allopurinol
Carcinoma, Squamous Cell
Brain Death
Head and Neck Neoplasms
Combined Modality Therapy
Cryopreservation
Fluorouracil
Cisplatin
Mannitol
Fertility Preservation
Reperfusion Injury
Liver Transplantation
Radiotherapy, Adjuvant
Graft Survival
Tissue Donors
Hydroxyurea
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols
Adenosine
Glutathione
Salvage Therapy
Neoplasm Staging
Graft Rejection
Survival Analysis
Tissue and Organ Procurement
Organ Transplantation
Liver
Survival Rate
Retrospective Studies
Follow-Up Studies
Disease-Free Survival
Semen Preservation
Multiple Organ Failure
Organ Specificity
Organ of Corti
Cold Ischemia
Freeze Drying
Beta-glucan reflects liver injury after preservation and transplantation in dogs. (1/524)
Graft failure and extrahepatic organ complications, which frequently develop after transplantation, may be related to inflammatory mediators stimulated by endotoxin (ET). The role of endotoxemia after liver transplantation is controversial and may depend upon differences in the ET assay method used in the various contradicting studies. While the standard Limulus amebocyte lysate (LAL) is reactive for ET and beta-glucan, a novel turbidimetric assay method enables separate determinations of ET and beta-glucan. Beagle dogs undergoing orthotopic liver transplantation were divided into two groups. In Group I (n = 6) the grafts were transplanted immediately and in Group II (n = 6) grafts were preserved for 48 h in University of Wisconsin (UW) solution. Animals received cyclosporine immunosuppression and were followed for 14 days. Daily measurements of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were performed. Samples for ET and beta-glucan measurement were collected serially and processed using the turbidimetric assay method. While no graft failure was seen in Group I, three of six Group II animals died from graft failure within 1 day after transplantation. Preservation and reperfusion injury was much more severe in the Group II grafts than in Group I grafts. While endotoxemia could not be detected, postoperative beta-glucan levels (undetectable pretransplant) were seen in both groups. Beta-glucan levels were much higher in Group II grafts than in Group I grafts, and correlated with the severity of liver damage. In conclusion, this study shows that beta-glucan, instead of ET, appears during the early posttransplant period. We believe that posttransplant elevation of beta-glucan is related to liver damage, especially endothelial damage by preservation and reperfusion. (+info)Tissue donation after death in the accident and emergency department: an opportunity wasted? (2/524)
OBJECTIVE: To investigate whether the accident and emergency department (A&E) is a potential source of tissues for donation, from non-heart beating donors (NHBDs). METHODS: A telephone survey of 30 A&E departments was conducted to determine current tissue harvesting practices from NHBDs. The potential number of tissue donors in our own medium sized district general hospital A&E department was estimated. Senior nursing staff were asked to complete a questionnaire to establish their knowledge, attitudes, and experience of tissue harvesting from NHBDs. RESULTS: Only seven of the 30 A&E departments surveyed (23%) had an active involvement in requesting tissue donation after a sudden death. Several others had limited experience. The level of involvement was unrelated to department size. In our own A&E department, there were 110 deaths in 1995. Tissue donation had occurred on just three occasions. However, departmental staff attitudes towards reducing this shortfall were positive. CONCLUSIONS: The A&E department is a resource of tissues for donation, which is currently under used. (+info)Intravenous glycine improves survival in rat liver transplantation. (3/524)
In situ manipulation by touching, retracting, and moving liver lobes gently during harvest dramatically reduces survival after transplantation (P. Schemmer, R. Schoonhoven, J. A. Swenberg, H. Bunzendahl, and R. G. Thurman. Transplantation 65: 1015-1020, 1998). The development of harvest-dependent graft injury upon reperfusion can be prevented with GdCl3, a rare earth metal and Kupffer cell toxicant, but it cannot be used in clinical liver transplantation because of its potential toxicity. Thus the effect of glycine, which prevents activation of Kupffer cells, was assessed here. Minimal dissection of the liver for 12 min plus 13 min without manipulation had no effect on survival (100%). However, gentle manipulation decreased survival to 46% in the control group. Furthermore, serum transaminases and liver necrosis were elevated 4- to 12-fold 8 h after transplantation. After organ harvest, the rate of entry and exit of fluorescein dextran, a dye confined to the vascular space, was decreased about twofold, indicating disturbances in the hepatic microcirculation. Pimonidazole binding, which detects hypoxia, increased about twofold after organ manipulation, and Kupffer cells isolated from manipulated livers produced threefold more tumor necrosis factor-alpha after lipopolysaccharide than controls. Glycine given intravenously to the donor increased the serum glycine concentration about sevenfold and largely prevented the effect of gentle organ manipulation on all parameters studied. These data indicate for the first time that pretreatment of donors with intravenous glycine minimizes reperfusion injury due to organ manipulation during harvest and after liver transplantation. (+info)Organ transplantation--then and now. (4/524)
The last 25 years have seen amazing progress in transplantation--from the development of techniques for immunosuppression to methods for organ removal and preservation. Our distinguished authors focus on these developments and discuss how the momentum seen during the last quarter century can be accelerated. (+info)A study on continuous low-flow perfusion with low-potassium dextran for donor isolated lung preservation. (5/524)
OBJECTIVE: To test the validity of continuous low-flow perfusion with low-potassium dextran (LPD) to preserve rabbit lung. METHODS: Isolated rabbit lungs were preserved for eight hours either in Ringer's solution by simple storage (Group I) or in continuous low-flow perfusion with LPD (Group II). After preservation, lung functions were assessed to compare these two methods. RESULTS: The water gain in Group I was higher than that in Group II. During reperfusion, the functional test values for the immersed lungs were lower than those for the perfused lungs. The lipid peroxidation product (MDA) was significantly decreased in perfused lungs during reperfusion. CONCLUSIONS: Low-flow perfusion with LPD is better than immersion for the lung preservation. (+info)The effects of mannitol, albumin, and cardioplegia enhancers on 24-h rat heart preservation. (6/524)
During 24 h in vitro heart preservation and reperfusion, tissue damage occurs that seriously reduces cardiac function. Prevention of free radical production during preservation and reperfusion of ischemic tissue using free radical scavengers is of primary importance in maintaining optimal heart function in long-term preservation protocols. We examined whether mannitol (68 mM) and albumin (1.4 microM) in combination with other cardioplegia enhancers decreased free radical formation and edema and increased cardiac function during 24-h cold (5 degrees C) heart preservation and warm (37 degrees C) reperfusion in the Langendorff-isolated rat heart. The performance of mannitol-treated hearts was significantly decreased compared with that of hearts without mannitol treatment after 24 h of preservation with regard to recovery of diastolic pressure, contractility (+dP/dt), relaxation (-dP/dt), myocardial creatine kinase release, coronary flow, and lipid peroxidation. Albumin-treated hearts demonstrated higher cardiac function (contractility and coronary flow especially) than hearts not treated with albumin or hearts treated with mannitol, and this appears to be due to the positive effects of increased cellular metabolism and the enhancement of membrane stability. (+info)Endothelium-dependent relaxation of canine pulmonary artery endothelium after prolonged preservation. (7/524)
OBJECTIVE: Experiments were designed to investigate the effect of Euro-Collins (EC) solution and University of Wisconsin (UW) solution on function of pulmonary arterial endothelium. METHODS: Third order canine pulmonary artery segments were preserved in cold (4 degrees C) UW (group 1, n = 8) or EC (group 2, n = 9) solutions for 16 hours. The preserved (group 1 and 2) and control (group 3, n = 7) pulmonary arterial segments with and without endothelium were studied in vitro in organ chambers to measure isometric tension. RESULTS: The endothelium-dependent relaxation to acetylcholine and adenosine diphosphate of group 1 and 3 were significantly better than those of group 2. CONCLUSIONS: We concluded that endothelium-dependent relaxation of canine pulmonary arterial endothelium to receptor-dependent acetylcholine and adenosine diphosphate were impaired after preservation with Euro-Collins solution. However, endothelium-dependent relaxation of pulmonary segments were well maintained after preservation with University of Wisconsin solution. (+info)Controlling transplant vasculopathy in cryopreserved vein grafts with polyethylene glycol and glutathione during transport. (8/524)
BACKGROUND: the biological characteristics of cryopreserved allografts are poorly understood, although many factors are known to influence their outcome. This study examines the development of transplant vasculopathy in both fresh and cryopreserved vein allografts and specifically assesses the efficacy of a transport solution containing 10% polyethylene glycol and 10 microM glutathione (PEG/GSH). METHODS: jugular veins were harvested from control donor rabbits and transplanted as interposition carotid bypass grafts in 30 New Zealand White (NZW) rabbits. Ten received the fresh jugular veins (fresh). Ten animals received jugular veins which had been harvested, transported in a physiological solution, cryopreserved and stored in a standard fashion (cryopreserved). Ten animals received jugular veins which had been harvested, transported in the same solution with the addition of PEG/GSH, cryopreserved and stored in a standard fashion (PEG/GSH). Cryopreserved jugular veins were stored for 6 weeks before transplantation. All animals were sacrificed 28 days postoperatively. Vein grafts were perfusion-fixed and wall dimensions were determined by planimetry. RESULTS: all transplanted grafts were patent at harvest. The control cryopreserved vein grafts showed a 54% increase in mean intimal thickness (63+/-10 micron vs. 41+/-3 micron p<0.05) but no change in mean medial thickness (125+/-9 micron vs. 119+/-13 micron; p = N.S. ) compared to the fresh allograft. Transport of the grafts in PEG/GSH solution resulted in the abolition of the increase in intimal thickness (41+/-4 micron; p <0.01) associated with cryopreservation without a change in medial thickness (140+/-15 micron; p = N.S.) compared to the cryopreserved allograft. CONCLUSION: cryopreserved vein grafts develop significant intimal hyperplasia compared to freshly transplanted grafts. The use of PEG/GSH in the transport solution significantly reduces this transplant graft intimal hyperplasia to that which develops in fresh grafts and may lead to improvements in the clinical use of cryopreserved veins. (+info)The most common types of laryngeal neoplasms include:
1. Vocal cord nodules and polyps: These are benign growths that develop on the vocal cords due to overuse, misuse, or trauma.
2. Laryngeal papillomatosis: This is a condition where warts grow on the vocal cords, often caused by the human papillomavirus (HPV).
3. Adenoid cystic carcinoma: This is a rare type of cancer that develops in the salivary glands near the larynx.
4. Squamous cell carcinoma: This is the most common type of cancer that develops in the larynx, often due to smoking or heavy alcohol consumption.
5. Verrucous carcinoma: This is a rare type of cancer that develops on the vocal cords and is often associated with chronic inflammation.
6. Lymphoma: This is a type of cancer that affects the immune system, and can develop in the larynx.
7. Melanoma: This is a rare type of cancer that develops from pigment-producing cells called melanocytes.
Symptoms of laryngeal neoplasms can include hoarseness or difficulty speaking, breathing difficulties, and ear pain. Diagnosis is typically made through a combination of physical examination, imaging tests such as CT scans or MRI, and biopsy. Treatment options vary depending on the type and severity of the neoplasm, but may include surgery, radiation therapy, or chemotherapy.
There are several types of hypopharyngeal neoplasms, including:
1. Squamous cell carcinoma (SCC): This is the most common type of hypopharyngeal cancer, accounting for about 90% of cases. It arises from the squamous cells that line the hypopharynx.
2. Adenocarcinoma: This type of cancer arises from the glandular cells that line the hypopharynx.
3. Other rare types: Other types of hypopharyngeal neoplasms include sarcomas, lymphomas, and melanomas.
The symptoms of hypopharyngeal neoplasms can vary depending on the location and size of the tumor. Common symptoms include:
1. Difficulty swallowing (dysphagia)
2. Pain when swallowing (odynophagia)
3. Hoarseness or voice changes
4. Lumps in the neck
5. Weight loss
6. Fatigue
7. Coughing up blood (hemoptysis)
8. Difficulty breathing (dyspnea)
Hypopharyngeal neoplasms are diagnosed through a combination of endoscopy, imaging tests such as CT scans or MRI, and biopsies. Treatment options include surgery, radiation therapy, chemotherapy, and targeted therapies. The prognosis for hypopharyngeal neoplasms depends on the stage and location of the tumor, as well as the patient's overall health.
In summary, hypopharyngeal neoplasms are a type of cancer that affects the lower part of the throat, and can be diagnosed through a combination of endoscopy, imaging tests, and biopsies. Treatment options include surgery, radiation therapy, chemotherapy, and targeted therapies, and the prognosis depends on the stage and location of the tumor, as well as the patient's overall health.
SCC typically appears as a firm, flat, or raised bump on the skin, and may be pink, red, or scaly. The cancer cells are usually well-differentiated, meaning they resemble normal squamous cells, but they can grow rapidly and invade surrounding tissues if left untreated.
SCC is more common in fair-skinned individuals and those who spend a lot of time in the sun, as UV radiation can damage the skin cells and increase the risk of cancer. The cancer can also spread to other parts of the body, such as lymph nodes or organs, and can be life-threatening if not treated promptly and effectively.
Treatment for SCC usually involves surgery to remove the cancerous tissue, and may also include radiation therapy or chemotherapy to kill any remaining cancer cells. Early detection and treatment are important to improve outcomes for patients with SCC.
The committee defined "brain death" as follows:
* The absence of any clinical or electrophysiological signs of consciousness, including the lack of response to pain, light, sound, or other stimuli.
* The absence of brainstem reflexes, such as pupillary reactivity, oculocephalic reflex, and gag reflex.
* The failure of all brain waves, including alpha, beta, theta, delta, and epsilon waves, as detected by electroencephalography (EEG).
* The absence of any other clinical or laboratory signs of life, such as heartbeat, breathing, or blood circulation.
The definition of brain death is important because it provides a clear and consistent criteria for determining death in medical settings. It helps to ensure that patients who are clinically dead are not inappropriately kept on life support, and that organ donation can be performed in a timely and ethical manner.
Some common types of head and neck neoplasms include:
1. Oral cavity cancer: Cancer that develops in the mouth, tongue, lips, or floor of the mouth.
2. Oropharyngeal cancer: Cancer that develops in the throat, including the base of the tongue, soft palate, and tonsils.
3. Hypopharyngeal cancer: Cancer that develops in the lower part of the throat, near the esophagus.
4. Laryngeal cancer: Cancer that develops in the voice box (larynx).
5. Paranasal sinus cancer: Cancer that develops in the air-filled cavities around the eyes and nose.
6. Salivary gland cancer: Cancer that develops in the salivary glands, which produce saliva to moisten food and keep the mouth lubricated.
7. Thyroid gland cancer: Cancer that develops in the butterfly-shaped gland in the neck that regulates metabolism and growth.
The risk factors for developing head and neck neoplasms include tobacco use, heavy alcohol consumption, human papillomavirus (HPV) infection, poor diet, and exposure to environmental carcinogens such as asbestos or radiation. Symptoms of head and neck neoplasms can vary depending on the location and size of the tumor, but may include a lump or swelling, pain, difficulty swallowing, bleeding, and changes in voice or breathing.
Diagnosis of head and neck neoplasms typically involves a combination of physical examination, imaging tests such as CT scans or MRI, and biopsy to confirm the presence of cancer cells. Treatment options can include surgery, radiation therapy, chemotherapy, targeted therapy, and immunotherapy, depending on the type, location, and stage of the cancer.
Overall, head and neck neoplasms can have a significant impact on quality of life, and early detection and treatment are important for improving outcomes. If you suspect any changes in your head or neck, it is essential to consult with a healthcare professional for an accurate diagnosis and appropriate treatment.
Reperfusion injury can cause inflammation, cell death, and impaired function in the affected tissue or organ. The severity of reperfusion injury can vary depending on the duration and severity of the initial ischemic event, as well as the promptness and effectiveness of treatment to restore blood flow.
Reperfusion injury can be a complicating factor in various medical conditions, including:
1. Myocardial infarction (heart attack): Reperfusion injury can occur when blood flow is restored to the heart muscle after a heart attack, leading to inflammation and cell death.
2. Stroke: Reperfusion injury can occur when blood flow is restored to the brain after an ischemic stroke, leading to inflammation and damage to brain tissue.
3. Organ transplantation: Reperfusion injury can occur when a transplanted organ is subjected to ischemia during harvesting or preservation, and then reperfused with blood.
4. Peripheral arterial disease: Reperfusion injury can occur when blood flow is restored to a previously occluded peripheral artery, leading to inflammation and damage to the affected tissue.
Treatment of reperfusion injury often involves medications to reduce inflammation and oxidative stress, as well as supportive care to manage symptoms and prevent further complications. In some cases, experimental therapies such as stem cell transplantation or gene therapy may be used to promote tissue repair and regeneration.
The definition of MOF varies depending on the context and the specific criteria used to define it. However, in general, MOF is characterized by:
1. The involvement of multiple organs: MOF affects multiple organs in the body, such as the lungs, liver, kidneys, heart, and brain. Each organ failure can have a significant impact on the individual's overall health and survival.
2. Severe dysfunction: The dysfunction of multiple organs is severe enough to cause significant impairment in the individual's physiological functions, such as breathing, circulation, and mental status.
3. Lack of specific etiology: MOF often occurs without a specific identifiable cause, although it can be triggered by various factors such as infections, injuries, or medical conditions.
4. High mortality rate: MOF is associated with a high mortality rate, especially if left untreated or if the underlying causes are not addressed promptly.
The diagnosis of MOF requires a comprehensive evaluation of the individual's medical history, physical examination, laboratory tests, and imaging studies. Treatment involves addressing the underlying causes, supporting the failing organs, and managing symptoms. The prognosis for MOF depends on the severity of the condition, the underlying cause, and the promptness and effectiveness of treatment.
Viaspan
Index of oral health and dental articles
Hammond Organ Reed Factory
Histidine-tryptophan-ketoglutarate
Severance Hall
Viability assay
East Kilbride Civic Centre
Wurlitzer theatre organs in the United Kingdom
Greg Fahy
Washington National Cathedral
List of churches in the Roman Catholic Diocese of Buffalo
State Theatre (Kalamazoo, Michigan)
2014 in science
Kidney paired donation
Assisted migration
Railway Preservation Society of Ireland
Assisted evolution
Holy Trinity Episcopal Church (Spring Lake, New Jersey)
Cell damage
Jinggu Town
Ames Research Center
Artificial ovary
Organ transplantation
Cells Alive System
Pineapple Fund
Digital preservation
Laryngectomy
Thomas Starzl
Patriot Youth League of Sweden
2018 Queen's Birthday Honours (Australia)
Hibernation
Euchambersia
Timeline of plesiosaur research
Trinity Episcopal Church (Melrose, Florida)
Grace Church (Manhattan)
Temple Mount
Hobart M. Cable
Edmund Blacket
Chinese alligator
Scyphozoa
Eastern blue-tongued lizard
Joseph Conrad
Church of the Redeemer, Sacrow
Lincoln Village, Milwaukee
United Nations General Assembly Building
Réseau Breton
Midland Theatre
The Kinks Are the Village Green Preservation Society
Monte Bolca
History of cheese
Hanover Lutheran Church
St. Vincent de Paul Catholic Church (Bayonne, New Jersey)
Dementia with Lewy bodies
List of landmark court decisions in the United States
New York State Fair
Stiftung Frauenkirche Dresden
Parkway Theatre (Baltimore)
Timeline of Portland, Maine
Aden Lava Flow Wilderness
Ancient Egyptian funerary practices
Former seizure medicine shows promise for improving donor organ preservation | NHLBI, NIH
New computer model is a key step toward low-temperature preservation of 3D tissues, organs
The Fair Organ Preservation Society Discussion Forum • Search
The promise of organ and tissue preservation to transform medicine - PubMed
Transplantation Market Size, Share, & Trends Analysis Report by Product (Tissue Products, Immunosuppressive Drugs, Preservation...
Geerard Beets about organ preservation in rectal cancer - Inspire2Live
NTS | Organpreservation
Organ Preservation Solutions Market Valuation to Outstrip | Transplant News
Subjects: Organ Preservation - Digital Collections - National Library of Medicine Search Results
Pelvic organ prolapse and uterine preservation: a survey of female gynecologists (POP-UP survey). | BMC Womens Health;20(1):...
Contact - Wzo.org - an organization dedicated to the preservation of zebras
Plenary - Kate Trinajstic - Exceptional Preservation of organs and musculature is early vertebrates from the Gogo Formation...
Organ Preservation in Patients with Rectal Adenocarcinoma Treated with Total Neoadjuvant Therapy<...
Outbreak Investigations in Healthcare Settings
| HAI | CDC
Rapidly Progressive Glomerulonephritis Workup: Laboratory Studies, Imaging Studies, Procedures
Registration Dossier - ECHA
Extending preservation time for donated livers | National Institutes of Health (NIH)
Services for Females | Fertility Care and Preservation
Biomarkers Search
UHN researchers publish groundbreaking clinical trial in lung transplantation
Publication Detail
Kevin Abbott, M.D., M.P.H. - NIDDK
Click to print
NOT-HL-19-678: Notice of Special Interest (NOSI): Bold New Bioengineering Research for Heart, Lung, Blood and Sleep Disorders...
Cancers | Free Full-Text | Development of a Patient Decision Aid for Rectal Cancer Patients with Clinical Complete Response...
Portal Regional da BVS
Gregory A[au] - Search Results - PubMed
Undergraduate Research | Graduate School at The University of British Columbia (UBC)
Larynx preservation7
- 1. Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II study. (nih.gov)
- 4. Long-term Results of a Multicenter Randomized Phase III Trial of Induction Chemotherapy With Cisplatin, 5-fluorouracil, ± Docetaxel for Larynx Preservation. (nih.gov)
- 6. [Induction chemotherapy and larynx preservation: is such practice useful? (nih.gov)
- 8. Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. (nih.gov)
- 1. Expression of p53 and Bcl-xL as predictive markers for larynx preservation in advanced laryngeal cancer. (nih.gov)
- 12. Does induction chemotherapy still have a role in larynx preservation strategies? (nih.gov)
- 16. Alteration of p53 pathway in squamous cell carcinoma of the head and neck: impact on treatment outcome in patients treated with larynx preservation intent. (nih.gov)
Tissue preservation2
- In 2011 she was awarded a QEII Fellowships from the ARC to continue work on soft tissue preservation within the Gogo fishes. (humanitix.com)
- The Qiagen PAXgene non-formalin tissue preservation product was used to stabilize tissue specimens without cross-linking biomolecules. (ucsc.edu)
Internal organs1
- The internal organs, comprising eyes, heart, stomach, liver and guts has provided the first direct evidence that the earliest jawed vertebrates conformed to the extant vertebrate body bauplan (Trinajstic et al 2022). (humanitix.com)
Transplantation6
- Growing incidence of organ failure has resulted in massive growth in the transplantation market. (researchandmarkets.com)
- Technological advancement in organ transplantation methods is another major factor supporting the market growth. (researchandmarkets.com)
- Delivering viable organs to matching recipients within the window of viability can often be the most challenging aspect of organ transplantation," says Dr. Seila Selimovic, director of NIBIB's Engineered Tissues program. (nih.gov)
- Dr. Rafika Bardi, head of the Tunisian Center for the Promotion of Organ Transplantation, said that "as in all the countries of the Maghreb. (arabnews.com)
- The American Transplant Congress is designed for physicians, surgeons, scientists, nurses, organ procurement personnel and pharmacists who are interested in the clinical and research aspects of solid organ and tissue transplantation. (atcmeeting.org)
- A variety of formats are planned that will encourage the exchange of new scientific and clinical information and support an interchange of opinions regarding care and management as well as socioeconomic, ethical, and regulatory issues relevant to organ and tissue transplantation. (atcmeeting.org)
Tissues3
- RESULTS: A total of 13 donor corneal tissues with a mean (SEM) preservation time of 11.8 days (0.4) were included for the analysis. (nih.gov)
- The Human Tissues and Organs Research Resource (HTORR) provides the biomedical research community with human tissues for research. (nih.gov)
- It is a leading source of human tissues, cells and organs for scientific research and is comprised of a nationwide network of 130 tissue source sites over 45 states, including organ procurement organizations, tissue banks, post-surgery and post-mortem donors. (nih.gov)
Rectal cancer1
- Patients who underwent TME after restaging and patients who underwent TME after regrowth had similar DFS rates.CONCLUSIONOrgan preservation is achievable in half of the patients with rectal cancer treated with total neoadjuvant therapy, without an apparent detriment in survival, compared with historical controls treated with chemoradiotherapy, TME, and postoperative chemotherapy. (elsevierpure.com)
Cryopreservation2
- Medical science is a key step closer to the cryopreservation of brain slices used in neurological research, pancreatic cells for the treatment of diabetes and even whole organs thanks to a new computer model that predicts how tissue's size will change during the preservation process. (nih.gov)
- Cryopreservation consists of preserving human individuals or organs at very low temperatures (less than -130°) in order to preserve them. (ewtn.com)
Squamous cell carc2
- 7. Long-term results of a phase II trial of induction chemotherapy with uracil-ftegafur (UFT), vinorelbine, and cisplatin (UFTVP) followed by radiotherapy concomitant with UFT and carboplatin (RT/UFTJ) in a primary site preservation setting for resectable locally advanced squamous cell carcinoma of larynx and hypopharynx. (nih.gov)
- 2. Expression of Bcl-2 family proteins in advanced laryngeal squamous cell carcinoma: correlation with response to chemotherapy and organ preservation. (nih.gov)
Viable1
- The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism). (nih.gov)
Predicts1
- 7. Overexpression of p53 predicts organ preservation using induction chemotherapy and radiation in patients with advanced laryngeal cancer. (nih.gov)
Transplants3
- A cluster of mucormycosis infections in patients with hematologic malignancies, stem cell transplants, and solid organ transplants. (cdc.gov)
- Prolonging the storage life of donated organs could eventually help increase the number of potential transplants. (nih.gov)
- By giving doctors and patients more time, this research could someday affect thousands of patients who are waiting for liver or other organ transplants. (nih.gov)
Donor4
- Researchers have been trying for years to find ways to extend the shelf life of donor hearts and other organs in an effort boost the organ supply and save lives. (nih.gov)
- Only in case of allocation of a donor kidney from the Netherlands to a center abroad, cold storage is still the default preservation method. (organpreservation.nl)
- Depending on where a donor and recipient live, this may not be enough time to transport the organ and prepare for surgery. (nih.gov)
- Campaigners in Algeria and Tunisia want to create registers of people who refuse to have their organs taken after their death - and anyone not on the list would be considered a potential donor by default. (arabnews.com)
Kidneys1
- This makes the Netherlands the first country worldwide to abandon static cold storage as standard preservation method for kidneys from these donors. (organpreservation.nl)
Chemotherapy3
- 10. Feasibility, toxicity, and efficacy of short induction chemotherapy of docetaxel plus cisplatin or carboplatin (TP) followed by concurrent chemoradio-therapy for organ preservation in advanced cancer of the hypopharynx, larynx, and base of tongue. (nih.gov)
- 5. Predictive markers for response to chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma. (nih.gov)
- 10. Organ preservation and treatment toxicity with induction chemotherapy followed by radiation therapy or chemoradiation for advanced laryngeal cancer. (nih.gov)
Kidney1
- In use are two devices, the Kidney Assist-transporter from Organ Assist and the LifePort Kidney Transporter from Organ Recovery Systems. (organpreservation.nl)
Boost1
- Rising demand for transplant products such as tissue products, immunosuppressants, and organ preservation solutions is a major factor anticipated to boost the market's growth during the forecast period. (researchandmarkets.com)
Donation4
- From a religious point of view, there is nothing to oppose organ donation and the taking of organs from corpses," he said. (arabnews.com)
- He and other Muslim theologians have argued that organ donation after death is "ongoing charity" - a pious act in Islam that outlives the person who performs it. (arabnews.com)
- Organ donation. (arabnews.com)
- She said the region lacked a "culture of donating organs" and that many people confuse organ donation with organ trafficking. (arabnews.com)
Preliminary1
- The study may also provide information about the effects of the test substance on neonatal morbidity, mortality, target organs in the offspring, and preliminary data on prenatal and postnatal developmental toxicity and serve as a guide for subsequent tests. (nih.gov)
Researchers2
Diagnosis1
- Rapid diagnosis is essential for organ preservation. (medscape.com)
Human4
- A new preservation method protected human livers during cooling and kept them healthy for more than 24 hours. (nih.gov)
- With existing techniques, human organs can be preserved for an average of nine hours. (nih.gov)
- Supercooling extends preservation time of human livers. (nih.gov)
- Part of the problem lies with laws restricting the harvesting of human organs, coupled with cultural or religious reticence, despite Muslim theologians' approval of organ donations. (arabnews.com)
Patients3
- There are many fertility preservation options available to female patients who are planning to undergo potential ovary-damaging medical treatments. (cincinnatichildrens.org)
- Many patients are critically ill as they wait for organs such as a heart which can only be taken from deceased donors. (arabnews.com)
- 6. Tumor angiogenesis as a predictive marker for organ preservation in patients with advanced laryngeal carcinoma. (nih.gov)
Life1
- The gift of an organ fulfils "one of the major objectives of Islamic law, which is the preservation of life," Chekkat said. (arabnews.com)
Source1
- All tissue specimens were reviewed by pathologists to characterize and verify organ source. (ucsc.edu)
Options2
- are among the many key firms working within the organ preservation options market. (transplant.news)
- Below is a summary of options provided by the Comprehensive Fertility Care & Preservation Program. (cincinnatichildrens.org)
Female1
- Pelvic organ prolapse and uterine preservation: a survey of female gynecologists (POP-UP survey). (bvsalud.org)
Increase1
- Thus, the availability of such advanced techniques supports an increase in the number of organ transplant procedures. (researchandmarkets.com)
Person2
- But under Algerian law, a living person can donate an organ only to a parent, child, sibling or spouse. (arabnews.com)
- But the law says organs may only be removed from a dead person if their family agrees. (arabnews.com)
Legal1
- is struggling to gain a foothold in Morocco, even though there are no prohibitions: not medical, legal or religious," Moroccan organ registrar Said Sabri told AFP. (arabnews.com)
Surgery1
- Bacterial contamination of organ preservation solution used in transplant surgery. (cdc.gov)