AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Organ PreservationOrgan Preservation SolutionsLaryngectomyRaffinoseLaryngeal NeoplasmsHypopharyngeal NeoplasmsAllopurinolPharyngectomyCarcinoma, Squamous CellBrain DeathHead and Neck NeoplasmsCombined Modality TherapyPreservation, BiologicalPancreas TransplantationCryopreservationFluorouracilCisplatinMannitolFertility PreservationReperfusion InjuryPerfusionLiver TransplantationRadiotherapy, AdjuvantGraft SurvivalTissue DonorsHydroxyureaTreatment OutcomeAntineoplastic Combined Chemotherapy ProtocolsRadiotherapy DosageAdenosineInsurance, Health, ReimbursementGlutathioneSalvage TherapyNeoplasm StagingKidney TransplantationGraft RejectionSurvival AnalysisTissue and Organ ProcurementOrgan TransplantationLiverSurvival RateRetrospective StudiesFollow-Up StudiesCyclic Nucleotide Phosphodiesterases, Type 3Semen PreservationFood PreservationMultiple Organ FailureOrgan SizeOrgan SpecificityOrgan of CortiCold IschemiaFreeze DryingTime FactorsBlood Preservation
Organ Preservation: The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Organ Preservation Solutions: Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.Laryngectomy: Total or partial excision of the larynx.Raffinose: A trisaccharide occurring in Australian manna (from Eucalyptus spp, Myrtaceae) and in cottonseed meal.Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.Hypopharyngeal Neoplasms: Tumors or cancer of the HYPOPHARYNX.Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.Pharyngectomy: Surgical removal of a part of the pharynx. (Dorland, 28th ed)Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Brain Death: A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Preservation, Biological: The process of protecting various samples of biological material.Pancreas Transplantation: The transference of a pancreas from one human or animal to another.Cryopreservation: Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Mannitol: A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.Fertility Preservation: A method of providing future reproductive opportunities before a medical treatment with known risk of loss of fertility. Typically reproductive organs or tissues (e.g., sperm, egg, embryos and ovarian or testicular tissues) are cryopreserved for future use before the medical treatment (e.g., chemotherapy, radiation) begins.Reperfusion Injury: Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.Perfusion: Treatment process involving the injection of fluid into an organ or tissue.Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Hydroxyurea: An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Radiotherapy Dosage: The total amount of radiation absorbed by tissues as a result of radiotherapy.Adenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Insurance, Health, Reimbursement: Payment by a third-party payer in a sum equal to the amount expended by a health care provider or facility for health services rendered to an insured or program beneficiary. (From Facts on File Dictionary of Health Care Management, 1988)Glutathione: A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Kidney Transplantation: The transference of a kidney from one human or animal to another.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Tissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Cyclic Nucleotide Phosphodiesterases, Type 3: A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.Semen Preservation: The process by which semen is kept viable outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Food Preservation: Procedures or techniques used to keep food from spoiling.Multiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.Organ Size: The measurement of an organ in volume, mass, or heaviness.Organ Specificity: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.Organ of Corti: The spiral EPITHELIUM containing sensory AUDITORY HAIR CELLS and supporting cells in the cochlea. Organ of Corti, situated on the BASILAR MEMBRANE and overlaid by a gelatinous TECTORIAL MEMBRANE, converts sound-induced mechanical waves to neural impulses to the brain.Cold Ischemia: The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.Freeze Drying: Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Blood Preservation: The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).

Beta-glucan reflects liver injury after preservation and transplantation in dogs. (1/524)

Graft failure and extrahepatic organ complications, which frequently develop after transplantation, may be related to inflammatory mediators stimulated by endotoxin (ET). The role of endotoxemia after liver transplantation is controversial and may depend upon differences in the ET assay method used in the various contradicting studies. While the standard Limulus amebocyte lysate (LAL) is reactive for ET and beta-glucan, a novel turbidimetric assay method enables separate determinations of ET and beta-glucan. Beagle dogs undergoing orthotopic liver transplantation were divided into two groups. In Group I (n = 6) the grafts were transplanted immediately and in Group II (n = 6) grafts were preserved for 48 h in University of Wisconsin (UW) solution. Animals received cyclosporine immunosuppression and were followed for 14 days. Daily measurements of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were performed. Samples for ET and beta-glucan measurement were collected serially and processed using the turbidimetric assay method. While no graft failure was seen in Group I, three of six Group II animals died from graft failure within 1 day after transplantation. Preservation and reperfusion injury was much more severe in the Group II grafts than in Group I grafts. While endotoxemia could not be detected, postoperative beta-glucan levels (undetectable pretransplant) were seen in both groups. Beta-glucan levels were much higher in Group II grafts than in Group I grafts, and correlated with the severity of liver damage. In conclusion, this study shows that beta-glucan, instead of ET, appears during the early posttransplant period. We believe that posttransplant elevation of beta-glucan is related to liver damage, especially endothelial damage by preservation and reperfusion.  (+info)

Tissue donation after death in the accident and emergency department: an opportunity wasted? (2/524)

OBJECTIVE: To investigate whether the accident and emergency department (A&E) is a potential source of tissues for donation, from non-heart beating donors (NHBDs). METHODS: A telephone survey of 30 A&E departments was conducted to determine current tissue harvesting practices from NHBDs. The potential number of tissue donors in our own medium sized district general hospital A&E department was estimated. Senior nursing staff were asked to complete a questionnaire to establish their knowledge, attitudes, and experience of tissue harvesting from NHBDs. RESULTS: Only seven of the 30 A&E departments surveyed (23%) had an active involvement in requesting tissue donation after a sudden death. Several others had limited experience. The level of involvement was unrelated to department size. In our own A&E department, there were 110 deaths in 1995. Tissue donation had occurred on just three occasions. However, departmental staff attitudes towards reducing this shortfall were positive. CONCLUSIONS: The A&E department is a resource of tissues for donation, which is currently under used.  (+info)

Intravenous glycine improves survival in rat liver transplantation. (3/524)

In situ manipulation by touching, retracting, and moving liver lobes gently during harvest dramatically reduces survival after transplantation (P. Schemmer, R. Schoonhoven, J. A. Swenberg, H. Bunzendahl, and R. G. Thurman. Transplantation 65: 1015-1020, 1998). The development of harvest-dependent graft injury upon reperfusion can be prevented with GdCl3, a rare earth metal and Kupffer cell toxicant, but it cannot be used in clinical liver transplantation because of its potential toxicity. Thus the effect of glycine, which prevents activation of Kupffer cells, was assessed here. Minimal dissection of the liver for 12 min plus 13 min without manipulation had no effect on survival (100%). However, gentle manipulation decreased survival to 46% in the control group. Furthermore, serum transaminases and liver necrosis were elevated 4- to 12-fold 8 h after transplantation. After organ harvest, the rate of entry and exit of fluorescein dextran, a dye confined to the vascular space, was decreased about twofold, indicating disturbances in the hepatic microcirculation. Pimonidazole binding, which detects hypoxia, increased about twofold after organ manipulation, and Kupffer cells isolated from manipulated livers produced threefold more tumor necrosis factor-alpha after lipopolysaccharide than controls. Glycine given intravenously to the donor increased the serum glycine concentration about sevenfold and largely prevented the effect of gentle organ manipulation on all parameters studied. These data indicate for the first time that pretreatment of donors with intravenous glycine minimizes reperfusion injury due to organ manipulation during harvest and after liver transplantation.  (+info)

Organ transplantation--then and now. (4/524)

The last 25 years have seen amazing progress in transplantation--from the development of techniques for immunosuppression to methods for organ removal and preservation. Our distinguished authors focus on these developments and discuss how the momentum seen during the last quarter century can be accelerated.  (+info)

A study on continuous low-flow perfusion with low-potassium dextran for donor isolated lung preservation. (5/524)

OBJECTIVE: To test the validity of continuous low-flow perfusion with low-potassium dextran (LPD) to preserve rabbit lung. METHODS: Isolated rabbit lungs were preserved for eight hours either in Ringer's solution by simple storage (Group I) or in continuous low-flow perfusion with LPD (Group II). After preservation, lung functions were assessed to compare these two methods. RESULTS: The water gain in Group I was higher than that in Group II. During reperfusion, the functional test values for the immersed lungs were lower than those for the perfused lungs. The lipid peroxidation product (MDA) was significantly decreased in perfused lungs during reperfusion. CONCLUSIONS: Low-flow perfusion with LPD is better than immersion for the lung preservation.  (+info)

The effects of mannitol, albumin, and cardioplegia enhancers on 24-h rat heart preservation. (6/524)

During 24 h in vitro heart preservation and reperfusion, tissue damage occurs that seriously reduces cardiac function. Prevention of free radical production during preservation and reperfusion of ischemic tissue using free radical scavengers is of primary importance in maintaining optimal heart function in long-term preservation protocols. We examined whether mannitol (68 mM) and albumin (1.4 microM) in combination with other cardioplegia enhancers decreased free radical formation and edema and increased cardiac function during 24-h cold (5 degrees C) heart preservation and warm (37 degrees C) reperfusion in the Langendorff-isolated rat heart. The performance of mannitol-treated hearts was significantly decreased compared with that of hearts without mannitol treatment after 24 h of preservation with regard to recovery of diastolic pressure, contractility (+dP/dt), relaxation (-dP/dt), myocardial creatine kinase release, coronary flow, and lipid peroxidation. Albumin-treated hearts demonstrated higher cardiac function (contractility and coronary flow especially) than hearts not treated with albumin or hearts treated with mannitol, and this appears to be due to the positive effects of increased cellular metabolism and the enhancement of membrane stability.  (+info)

Endothelium-dependent relaxation of canine pulmonary artery endothelium after prolonged preservation. (7/524)

OBJECTIVE: Experiments were designed to investigate the effect of Euro-Collins (EC) solution and University of Wisconsin (UW) solution on function of pulmonary arterial endothelium. METHODS: Third order canine pulmonary artery segments were preserved in cold (4 degrees C) UW (group 1, n = 8) or EC (group 2, n = 9) solutions for 16 hours. The preserved (group 1 and 2) and control (group 3, n = 7) pulmonary arterial segments with and without endothelium were studied in vitro in organ chambers to measure isometric tension. RESULTS: The endothelium-dependent relaxation to acetylcholine and adenosine diphosphate of group 1 and 3 were significantly better than those of group 2. CONCLUSIONS: We concluded that endothelium-dependent relaxation of canine pulmonary arterial endothelium to receptor-dependent acetylcholine and adenosine diphosphate were impaired after preservation with Euro-Collins solution. However, endothelium-dependent relaxation of pulmonary segments were well maintained after preservation with University of Wisconsin solution.  (+info)

Controlling transplant vasculopathy in cryopreserved vein grafts with polyethylene glycol and glutathione during transport. (8/524)

BACKGROUND: the biological characteristics of cryopreserved allografts are poorly understood, although many factors are known to influence their outcome. This study examines the development of transplant vasculopathy in both fresh and cryopreserved vein allografts and specifically assesses the efficacy of a transport solution containing 10% polyethylene glycol and 10 microM glutathione (PEG/GSH). METHODS: jugular veins were harvested from control donor rabbits and transplanted as interposition carotid bypass grafts in 30 New Zealand White (NZW) rabbits. Ten received the fresh jugular veins (fresh). Ten animals received jugular veins which had been harvested, transported in a physiological solution, cryopreserved and stored in a standard fashion (cryopreserved). Ten animals received jugular veins which had been harvested, transported in the same solution with the addition of PEG/GSH, cryopreserved and stored in a standard fashion (PEG/GSH). Cryopreserved jugular veins were stored for 6 weeks before transplantation. All animals were sacrificed 28 days postoperatively. Vein grafts were perfusion-fixed and wall dimensions were determined by planimetry. RESULTS: all transplanted grafts were patent at harvest. The control cryopreserved vein grafts showed a 54% increase in mean intimal thickness (63+/-10 micron vs. 41+/-3 micron p<0.05) but no change in mean medial thickness (125+/-9 micron vs. 119+/-13 micron; p = N.S. ) compared to the fresh allograft. Transport of the grafts in PEG/GSH solution resulted in the abolition of the increase in intimal thickness (41+/-4 micron; p <0.01) associated with cryopreservation without a change in medial thickness (140+/-15 micron; p = N.S.) compared to the cryopreserved allograft. CONCLUSION: cryopreserved vein grafts develop significant intimal hyperplasia compared to freshly transplanted grafts. The use of PEG/GSH in the transport solution significantly reduces this transplant graft intimal hyperplasia to that which develops in fresh grafts and may lead to improvements in the clinical use of cryopreserved veins.  (+info)

Global Hypothermic Machine Perfusion Preservation Sales Market Report 2021 : ReportsnReportsGlobal Hypothermic Machine Perfusion Preservation Sales Market Report 2021 : ReportsnReports
[100 Pages Report] Check for Discount on Global Hypothermic Machine Perfusion Preservation Sales Market Report 2021 report by QYResearch Group. Notes: Sales, means the sales volume of Hypothermic Machine Perfusion...
Systematic review and meta‐analysis of hypothermic machine perfusion versus static cold storage of kidney allografts on...Systematic review and meta‐analysis of hypothermic machine perfusion versus static cold storage of kidney allografts on...
Adequate preservation of renal allografts for transplantation is important for maintaining and improving transplant outcomes. There are two prevalent methods: hypothermic machine perfusion and static cold storage. The preferred method of storage, however, remains controversial. The objective was to review systematically the evidence comparing outcomes from these two modalities. ...
Recovery of Energy Stores of Non-Heart-Beating Donor Livers Following Preservation by Hypothermic Machine Perfusion | Heat...Recovery of Energy Stores of Non-Heart-Beating Donor Livers Following Preservation by Hypothermic Machine Perfusion | Heat...
The shortage of donor organs for liver transplantation requires investigations into expanding the donor pool. Non-heart beating donor (NHBD) livers are an untapped source of organs. NHBD organs are those that have had a period of warm ischemia prior to cold preservation. A main concern of NHBD livers is that there is a depletion of energy stores during the warm ischemia and subsequent cold storage. This study is to investigate the use of hypothermic machine perfusion to regenerate energy stores in the liver during 5hr storage and after 1hr rewarming in a rat transplantation model. Results will be compared with control. (no warm ischemia) and simple cold stored tissues.. Copyright © 2003 by ASME ...
UC Health performs first liver transplant in US using mobile cold perfusion pump - Organ Donation and Transplantation AllianceUC Health performs first liver transplant in US using mobile cold perfusion pump - Organ Donation and Transplantation Alliance
Transplant surgeons at UC Healths University of Cincinnati (UC) Medical Center have performed the first-ever liver transplant in the United States with an organ preserved using portable hypothermic machine perfusion. The technology, which had been under development for several years, is designed to circulate a specially formulated, cold-temperature medical solution throughout a donor liver during its journey from the point of donation to surgical transplantation into a recipient.. This "active" preservation device was invented to improve upon traditional "static" cold preservation, which stores the liver in a cool box filled with ice. Static cold storage has been the standard of care for liver preservation since the first successful liver transplant was performed in the United States in 1967.. The procedure at UC Health was done as part of the first multicenter clinical trial comparing portable hypothermic machine preservation of donated livers with livers placed in static cold storage prior to ...
Impact of 24 h continuous hypothermic perfusion on heart preservation by assessment of oxidative stress<...Impact of 24 h continuous hypothermic perfusion on heart preservation by assessment of oxidative stress<...
TY - JOUR. T1 - Impact of 24 h continuous hypothermic perfusion on heart preservation by assessment of oxidative stress. AU - Fitton, Torin P.. AU - Wei, Chiming. AU - Lin, Ruxian. AU - Bethea, Brian T.. AU - Barreiro, Christopher J.. AU - Amado, Luciano. AU - Gage, Fred. AU - Hare, Joshua. AU - Baumgartner, William A.. AU - Conte, John V.. PY - 2004/9/23. Y1 - 2004/9/23. N2 - Introduction: Despite investigating numerous solutions, additives, and techniques over the last two decades, extending donor heart preservation beyond 4-6 h has not been achieved. Hypothermic heart preservation (HP) induces oxidative stress (OS) with reactive oxygen species (ROS) production, causing DNA cleavage and impairing repair. Quantification of cardiomyocyte concentrations of DNA damage by-products (8-oxoG) and mismatch repair enzymes (MYH, OGG-1, MSH2) reflects the severity of OS. If increased repair enzyme production is insufficient to repair injury, cell death occurs and functional outcomes are impacted. We ...
Endothelin receptor blockade during hypothermic perfusion preservation mitigates the adverse effect of preretrieval warm...Endothelin receptor blockade during hypothermic perfusion preservation mitigates the adverse effect of preretrieval warm...
TY - JOUR. T1 - Endothelin receptor blockade during hypothermic perfusion preservation mitigates the adverse effect of preretrieval warm ischemic injury on posttransplant glomerular filtration rate. AU - Inman, Sharon R.. AU - Burns, Thomas E.. AU - Plott, Wanda K.. AU - Pomilee, Ray A.. AU - Antonelli, Jodi A.. AU - Lewis, Richard M.. PY - 2002/7/27. Y1 - 2002/7/27. N2 - Background. Preretrieval warm ischemic injury predisposes to both short-term and long-term dysfunction of cadaveric renal allografts. We previously reported that the excretion of the vasoactive peptide, endothelin (ET), is significantly increased during hypothermic perfusion preservation (HPP) of kidneys subjected to preretrieval warm ischemia compared with nonischemic controls. As such, the purpose of this study was to determine if endothelin receptor (ET-R) blockade during HPP would improve glomerular filtration rate (GFR) of kidneys subjected to preretrieval warm ischemia when measured in situ at 2 weeks after ...
Hypothermic Machine Perfusion in Kidney Transplantation: Back to the Future? | OMICS InternationalHypothermic Machine Perfusion in Kidney Transplantation: Back to the Future? | OMICS International
Static cold storage is currently the most used method of organ preservation worldwide. However, cutting edge technology and dramatic changes in the donor pattern have lat..
Hypothermic Machine Perfusion with Ulinastatin in Pancreas Preservation Improved Islet Yield and Function in Islet Isolation -...Hypothermic Machine Perfusion with Ulinastatin in Pancreas Preservation Improved Islet Yield and Function in Islet Isolation -...
Maintaining islet viability after pancreas procurement is critical for optimal graft function and survival in islet transplantation. It is recently reported that islet yield and function were significantly higher for pancreas preserved in the modified solution added with trypsin inhibitor (ulinastatin). In this study, the FDA-cleared LifePort ® platform was applied for porcine pancreas preservation, which provided a pulsatile circulation of a perfusate with KPS1 solution added with ulinastatin (100×103 U/L) during preservation. In the control group, pancreas was preserved by traditional cold storage. After 24 hours, the pancreas was distended by intraductal collagenase NB injection and normothermically digested. The isolated islets were purified by a continuous density-gradient centrifugation. The islet yield, islet viability, stimulation index and postpreservation edema were compared between the ulinastatin group (n=7) and control group (n=8). There was difference of islet yield (IEQ/g of ...
The role of interleukin-1β as a predictive biomarker and potential therapeutic target during clinical ex vivo lung perfusion -...The role of interleukin-1β as a predictive biomarker and potential therapeutic target during clinical ex vivo lung perfusion -...
2017 The Authors. Background: Extended criteria donor lungs deemed unsuitable for immediate transplantation can be reconditioned using ex vivo lung perfusion (EVLP). Objective identification of which donor lungs can be successfully reconditioned and will function well post-operatively has not been established. This study assessed the predictive value of markers of inflammation and tissue injury in donor lungs undergoing EVLP as part of the DEVELOP-UK study. Methods: Longitudinal samples of perfusate, bronchoalveolar lavage, and tissue from 42 human donor lungs undergoing clinical EVLP assessments were analyzed for markers of inflammation and tissue injury. Levels were compared according to EVLP success and post-transplant outcomes. Neutrophil adhesion to human pulmonary microvascular endothelial cells (HPMECs) conditioned with perfusates from EVLP assessments was investigated on a microfluidic platform. Results: The most effective markers to differentiate between in-hospital survival and ...
The effect of ex vivo lung perfusion on proinflammatory and anti-inflammatory cytokines in the human lung - Northumbria...The effect of ex vivo lung perfusion on proinflammatory and anti-inflammatory cytokines in the human lung - Northumbria...
Ex vivo lung perfusion (EVLP) is an emerging technique for the re-conditioning of damaged donor lungs prior to transplantation. Previous work has demonstrated improvement in gas exchange in lungs subjected to this technique; however, the effect of EVLP on inflammation has not yet been examined. We hypothesised that a potential benefit of EVLP in re-conditioning donor lungs may be due to modification of the inflammatory profile.. ...
Perfusion preservation solution for recovery of Donation by Cardiac Death livers | SBIR.govPerfusion preservation solution for recovery of Donation by Cardiac Death livers | SBIR.gov
DESCRIPTION (provided by applicant): The long term goal of this project is to increase the number of Donation after Cardiac Death (DCD) livers available for transplantation by developing a new hypothermic machine perfusion (HMP) solution for recovery and preservation. Currently DCD livers are transplantable and have the potential to increase the donor pool 20-40%. However, they are largely under utilized due to poor preservation by the current method of simple cold storage (SCS). Studies show that HMP can improve graft survival in animal models. However, as warm ischemic time is increased, preliminary studies show that the current HMP solution is not sufficient to address the increase stresses of extended warm ischemia. A new solution has been developed to address depletion of energy substrates, increased membrane instability, increased oxidation damage, and microcirculation disruption. Preliminary studies suggest that this new HMP solution has potential to recover and preserve extended warm ...
Hypothermic machine preservation in liver transplantation revisited: concepts and criteria in the new millennium. - Surgical...Hypothermic machine preservation in liver transplantation revisited: concepts and criteria in the new millennium. - Surgical...
To overcome the present shortage of liver donors by expansion of the existing donor pool and possibly lengthening of the storage time, hypothermic machine perfusion of the liver as a dynamic preservation method is revisited. The three most important aspects are defined to be the type of preservation solution, the characteristics of perfusion dynamics, and the oxygen supply. Reviewing hypothermic liver machine perfusion experiments, the University of Wisconsin machine preservation solution is the solution most used. It is also found that nothing conclusive can be said about the optimal perfusion characteristics, since either perfusion pressure or perfusion flow is reported. The best estimation is perfusion of the liver in a physiological manner, i.e. pulsatile arterial perfusion and continuous portal venous perfusion. The applied pressures could be chosen to be somewhat lower than physiological pressures to prevent possible endothelial cell damage. Oxygen supply is necessary to achieve optimal
Perfusion System Market, 2025 - Focus on Hypothermic Machine Perfusion, Normothermic Machine PerfusionPerfusion System Market, 2025 - Focus on Hypothermic Machine Perfusion, Normothermic Machine Perfusion
DUBLIN, June 27, 2017 /PRNewswire/ -- Research and Markets has announced the addition of the Perfusion System Market Analysis By Technology (Hypothermic...
A randomized prospective trial of cold storage versus pulsatile perfusion for cadaver kidney preservation. - Semantic ScholarA randomized prospective trial of cold storage versus pulsatile perfusion for cadaver kidney preservation. - Semantic Scholar
In a randomized trial conducted in 9 Ontario transplant centers, 107 cadaver kidney donors were randomized so that both kidneys were preserved either by simple cold storage (CS) or by pulsatile perfusion (PP). After exclusions and losses to follow-up, there were 90 patients in the CS group and 91 in the PP group. Total preservation times were similar in the two groups (27.7 +/- 12 and 30.5 +/- 10 hr), as was the proportion of kidneys with long (greater than 36 hr) storage times (21% and 26%). Twelve-month graft survival was 70% for CS and 75% for PP (not significant, NS); patient survival was 89% for CS and 95% for PP (NS). The incidence of kidneys that never functioned was also similar in the two groups (14% vs. 15%, respectively). However, the risk of early, reversible graft dysfunction was significantly higher for CS (44%) than for PP (31%). The same effect was observed with two independent methods of assessment of graft function. The chief effect of PP on renal function was in reduction of the mean
The effect of preservation solutions for storage of liver allografts on transplant outcomes: a systematic review and meta...The effect of preservation solutions for storage of liver allografts on transplant outcomes: a systematic review and meta...
OBJECTIVE: The objective of this review was to systematically evaluate the evidence comparing preservation fluids for liver allografts on transplant outcomes. BACKGROUND: Adequate preservation of liver allografts for transplantation is essential for successful transplant outcomes. There are several preservation fluids available that have been specifically designed for the static cold storage of livers. These fluids differ in composition and cost. METHODS: literature search was performed using MEDLINE, EMBASE, Cochrane Library, Transplant Library, and the International Clinical Trials Registry Platform. Only randomized controlled trials were included. Studies were assessed for methodological quality. Primary outcomes were the risk of early dysfunction, primary nonfunction, retransplantation, patient survival, and graft survival. Secondary outcomes were serum biochemical parameters in the first week and biliary complications. Summary effects were calculated as relative risk and relative log survival with
Positive cultures of organ preservation fluid predict postoperative infections in solid organ transplantation recipients |...Positive cultures of organ preservation fluid predict postoperative infections in solid organ transplantation recipients |...
Organ preservation fluid is not routine cultured at most centers. However, there are several reports of candida transmission from organ preservation fluid. ¾In this single-center retrospective study, the authors describe the microbiology of organ preservation fluid samples for 331 organs. Preservation fluid was positive in more than 60% of cases although the majority of these were low risk organisms such as coagulase negative Staphylococcus. However, some important organisms were isolated including Staphylococcus aureus, Gram-negative bacilli, and Candida spp. and these appear to increase the risk of post-operative infections. It is very likely, however, that the majority of organisms isolated would be covered by perioperative antimicrobials and only unusual organisms such as multidrug resistant bacteria or fungi may be transmitted. Therefore, it still remains unclear whether preservative fluid cultures are useful to guide post-operative antimicrobial management.. ...
The influence of pulsatile preservation in kidney transplantation from non-heart-beating donors. - Nuffield Department of...The influence of pulsatile preservation in kidney transplantation from non-heart-beating donors. - Nuffield Department of...
Continuous hypothermic pulsatile perfusion (CHPP) may offer improved early function compared with cold static perfusion (CSP) for heart-beating cadaveric donors. With an expanding pool of donors, ie, non-heart-beating donors (NHBD), we present our preliminary results with the use of CHPP compared with CSP to preserve kidney grafts retrieved from NHBD. Eighteen consecutive locally procured cadaveric kidneys from NHBD were preserved using CHPP using UW machine perfusion solution in the Life Port kidney transporter. Perfusion parameters were measured serially during pulsatile perfusion. This group was compared with 18 NHBD cadaveric kidneys preserved with CSP. No organs were lost due to faulty technique of preparation or preparation of pulsatile perfusion. Immediate renal function was observed in 13 cases (72.2%). In CSP in NHBD, we had 16 cases with delayed graft function (88.8%). These early results show that the use of pulsatile perfusion to preserve kidneys from NHBD may be associated with improved
Adenosine A2A agonist improves lung function during ex vivo lung perfusionAdenosine A2A agonist improves lung function during ex vivo lung perfusion
Moradian N, Ochs HD, Sedikies C, Hamblin MR, Camargo CA Jr, Martinez JA, Biamonte JD, Abdollahi M, Torres PJ, Nieto JJ, Ogino S, Seymour JF, Abraham A, Cauda V, Gupta S, Ramakrishna S, Sellke FW, Sorooshian A, Wallace Hayes A, Martinez-Urbistondo M, Gupta M, Azadbakht L, Esmaillzadeh A, Kelishadi R, Esteghamati A, Emam-Djomeh Z, Majdzadeh R, Palit P, Badali H, Rao I, Saboury AA, Jagan Mohan Rao L, Ahmadieh H, Montazeri A, Fadini GP, Pauly D, Thomas S, Moosavi-Movahed AA, Aghamohammadi A, Behmanesh M, Rahimi-Movaghar V, Ghavami S, Mehran R, Uddin LQ, Von Herrath M, Mobasher B, Rezaei N. ...
JCI - Cardiac preservation is enhanced in a heterotopic rat transplant model by supplementing the nitric oxide pathway.JCI - Cardiac preservation is enhanced in a heterotopic rat transplant model by supplementing the nitric oxide pathway.
Nitric oxide (NO) is a novel biologic messenger with diverse effects but its role in organ transplantation remains poorly understood. Using a porphyrinic microsensor, the first direct measurements of coronary vascular and endocardial NO production were made. NO was measured directly in the effluent of preserved, heterotopically transplanted rat hearts stimulated with L-arginine and bradykinin; NO concentrations fell from 2.1 +/- 0.4 microM for freshly explanted hearts to 0.7 +/- 0.2 and 0.2 +/- 0.08 microM for hearts preserved for 19 and 38 h, respectively. NO levels were increased by SOD, suggesting a role for superoxide-mediated destruction of NO. Consistent with these data, addition of the NO donor nitroglycerin (NTG) to a balanced salt preservation solution enhanced graft survival in a time- and dose-dependent manner, with 92% of hearts supplemented with NTG surviving 12 h of preservation versus only 17% in its absence. NTG similarly enhanced preservation of hearts stored in University of ...
British Library EThOS: Strategies for normothermic preservation of liversBritish Library EThOS: Strategies for normothermic preservation of livers
Cold preservation is currently the basis of organ preservation. However, prolonged duration of cold storage or preservation of marginal organs leads to inferior outcome. Primary non-function of liver occurs in 3.5-6% of patients requiring retransplantation. Many marginal organs such as severely steatotic livers and non-heart-beating donor livers are either not retrieved or discarded after retrieval due to concerns regards viability. A better method of preservation could enable utilisation of many of these organs and increase the donor pool. This thesis describes and demonstrates successful preservation of livers at body temperature using normothermic perfusion. It aims to make preservation physiological, improve outcomes following transplantation and increase the number of donor livers that can be transplanted by allowing use of more marginal livers ...
Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver - Zurich Open...Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver - Zurich Open...
Ischemia and reperfusion lead to injury of the liver. Ischemia-reperfusion injury is inevitable in liver transplantation and trauma and, to a great extent, in liver resection. This article gives an overview of the mechanisms involved in this type of injury and summarizes protective and treatment strategies in clinical use today. Intervention is possible at different time points: during harvesting, during the period of preservation, and during implantation. Liver preconditioning and postconditioning can be applied in the transplant setting and for liver resection. Graft optimization is merely possible in the period between the harvest and the implantation. Given that there are 3 stages in which a surgeon can intervene against ischemia-reperfusion injury, we have structured the review as follows. The first section reviews the approaches using surgical interventions, such as ischemic preconditioning, as well as pharmacological applications. In the second section, static organ preservation and ...
KAKEN - Research Projects | The experimental study of long-term heart preservation with the combined method of simple immersion...KAKEN - Research Projects | The experimental study of long-term heart preservation with the combined method of simple immersion...
Principal Investigator：MORISHITA Yasuo, Project Period (FY)：1996 - 1998, Research Category：Grant-in-Aid for Scientific Research (B), Section：一般, Research Field：Thoracic surgery
Organ Preservation Market, Size, Share, Outlook and Growth Opportunities 2019-2026Organ Preservation Market, Size, Share, Outlook and Growth Opportunities 2019-2026
Organ Preservation Market, Size, Outlook 2019 to 2026 Categorizes the Global Market by Type, By Application and by Region - Industry Analysis, Size, Share, Growth Opportunities, Trends, and Forecast Report
Transplantation after ex … - University of Gothenburg, SwedenTransplantation after ex … - University of Gothenburg, Sweden
A large proportion of donor lungs are discarded due to known or presumed organ dysfunction. Ex vivo lung perfusion (EVLP) has proven its value as a tool for discrimination between reversible and irreversible donor lung pathology. However, the long-term outcome after transplantation of lungs after EVLP is essentially unknown. We report short-term and midterm outcomes of recipients who received transplants of EVLP-evaluated lungs. ...
Machine Perfusion of Donor Livers for Transplantation: A Proposal for Standardized Nomenclature and Reporting Guidelines.Machine Perfusion of Donor Livers for Transplantation: A Proposal for Standardized Nomenclature and Reporting Guidelines.
Karangwa, S., Dutkowski, P., Fontes, P., Friend, P., Guarrera, J., Markmann, J., Mergental, H., et al. (2016). Machine Perfusion of Donor Livers for Transplantation: A Proposal for Standardized Nomenclature and Reporting Guidelines.. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 16 (10), 2932-2942. https://doi.org/10.1111/ajt.13843 ...
ISRCTN - ISRCTN50082383: CArdiac Death kidney Machine Perfusion trialISRCTN - ISRCTN50082383: CArdiac Death kidney Machine Perfusion trial
There is an international shortage of kidneys for transplantation, and there is great interest in optimising the kidneys available, in order to ensure that kidney transplants last for as long as possible with the best long-term function. When kidneys are recovered from deceased donors they inevitably face a period of storage while they are shipped to the recipient hospital and the logistics of transplantation are put into place. It has been shown that this period of storage can be harmful to kidneys and so this study aims to test which of two commonly used storage techniques is best for kidney transplant outcome. The first technique is cold static storage in which the kidney is placed in cold preservation solution and transported in a box of ice. The second is cold pulsatile machine perfusion in which the kidney is placed on a machine that pumps preservation fluid around the kidney ...
Concerning Preservation Technique - Mushroom Cultivation - Shroomery Message BoardConcerning Preservation Technique - Mushroom Cultivation - Shroomery Message Board
I think I may have hit upon a good idea for preserving mushrooms over long periods of time. This in in the absence of having a proper vacuum packing capability. After the shrooms are dry, I wrap
British Library EThOS: 8 day kidney preservationBritish Library EThOS: 8 day kidney preservation
The aims of this research were to investigate the factors that limit in vitro storage of kidneys, establish how long kidneys could be preserved when storage conditions were made optimum, and determine whether measurements of the release of - the lysosomal enzyme N-Acetyl glucosaminidase, by kidneys during storage, could be used to predict the function of the kidneys after reimplantation. Methods are needed for storing human kidneys, after removal from cadaver donors, to allow sufficient time for transport of the kidneys, tissue typing of the donors, and pre-operative preparation of the recipients. At present, reliable 24 hour storage would provide adequate time for these -procedures to be performed. In future, as tissue typing techniques become more refined, and as more potential recipients develop antibodies as a result of previous failed transplants, it is likely that fewer kidneys will be able to be matched with recipients in the locality of the donor. , It will then be necessary to store ...
6 Committee comments | Normothermic extracorporeal preservation of hearts for transplantation following donation after...6 Committee comments | Normothermic extracorporeal preservation of hearts for transplantation following donation after...
Evidence-based recommendations on normothermic extracorporeal heart preservation for transplantation following donation after brainstem death
Machine perfusion versus cold storage of kidneys derived from donation after cardiac death: a meta-analysisMachine perfusion versus cold storage of kidneys derived from donation after cardiac death: a meta-analysis
MP preservation of DCD kidneys is superior to CS in terms of reducing DGF rate post-transplant. However, primary non-function, one year graft survival, and one year patient survival were not affected by the use of MP or CS for preservation.
What is the equation for: Gaseous ammonia reacts with gaseous oxygen to form gaseous nitrogen monoxide and gaseous water? |...What is the equation for: Gaseous ammonia reacts with gaseous oxygen to form gaseous nitrogen monoxide and gaseous water? |...
2NH_3(g) + 5/2O_2(g) rarr 2NO(g) + 3H_2O(g) Is this balanced? How do you know? Is this reaction a redox reaction? Could oxidation to NO_2(g) occur?
Petition · Demand an End to Dog Experiments in Australia · Change.orgPetition · Demand an End to Dog Experiments in Australia · Change.org
Dogs are used in Australian laboratories for toxicity testing, infection inducement, aversive stimuli behavioural testing, and more. Humane Research Australia has also exposed the use of beagles for pharmaceutical drug testing, and the use of greyhounds in brain experiments, heart surgery experiments (where heart failure is induced to test blood pump devices, blood flow devices are tested, or circulatory death is induced to test heart preservation devices for transplantation), dental surgery experiments, terminal blood donation experiments, and others ...
militaria | American Chimeramilitaria | American Chimera
Last September saw the introduction of H.R. 6234 by U.S. Representative Paul Cook (R - CA), titled "Private Corrado Piccoli Purple Heart Preservation Act." It sought to make…. Read More ...
WWI | American ChimeraWWI | American Chimera
Last September saw the introduction of H.R. 6234 by U.S. Representative Paul Cook (R - CA), titled "Private Corrado Piccoli Purple Heart Preservation Act." It sought to make…. Read More ...
The day in posts: 06/12/2011 | MetaFilterThe day in posts: 06/12/2011 | MetaFilter
Iori Tomita: New World Transparent Specimens If youre a fish, Iori Tomita can see right through you. Or at least he can after hes worked you over in his lab. A lifelong fisherman who studied ichthyology as an undergrad, the Japanese artist uses marine life he receives from fellow fishermen to create what he calls New World Transparent Specimens-sea creatures that have been transformed into DayGlo shells of their former selves. He first saw a sample of a fish that had been turned transparent at a university lecture six years ago, and since then he has used the same preservation technique to make thousands of hypercolored cadavers, which he sells at the Tokyu Hands department store ...
NERC - Data centresNERC - Data centres
NERC has a network of environmental data centres that provide a focal point for NERCs scientific data and information. These centres hold data from environmental scientists working in the UK and around the world. The data centres are responsible for maintaining environmental data and making them available to all users, not just NERC researchers but others from science, commerce, government and education as well as the general public.. It is essential that data generated through NERC supported activities are properly managed to ensure their long-term availability. The data centres are experts in the collection of scientific information, state-of-the-art data management and preservation techniques, resulting in a high quality and important national asset available to all.. The range of data held within the data centres is vast, covering all aspects of environmental science. Some centres also hold physical specimens and sample materials collected during NERCs activities, as well as material ...
Much Thanks To Original IPA Innovators | Community | BeerAdvocateMuch Thanks To Original IPA Innovators | Community | BeerAdvocate
I was recently informed that IPA was originally created to increase preservation time for shipping, due to malts lack there of (at least in those times...
Organ Reperfusion & Preservation - Paragonix TechnologiesOrgan Reperfusion & Preservation - Paragonix Technologies
Paragonix Technologies develops and markets organ preservation transportation devices, designed to ensure that the organ receives every possible advantage.
Family Preservation Essay - 2637 WordsFamily Preservation Essay - 2637 Words
Family Preservation 1 Running Head: Preservation FAMILY PRESERVATION HERZING COLLEGE Family Preservation 2 Abstract The scope of my paper will address
Oxford Med-Tech Innovation with Impact 2014 | University of OxfordOxford Med-Tech Innovation with Impact 2014 | University of Oxford
Oxford Med-Tech, the Isis Innovation Technology Showcase 2014, highlighted the best new technology opportunities from Oxford University and our partners, including sought-after brain mapping software and pioneering organ preservation technology.
The Preservation of Glazed Terra Cotta | Old House WebThe Preservation of Glazed Terra Cotta | Old House Web
NPS Preservation Brief 7 By de Teel Patterson TillerArchitectural Historian, Technical Preservation Services What is terra-cotta?
Preservation | Panasonic | LabnetPreservation | Panasonic | Labnet
Tämä sähköpostiosoite on suojattu spamboteilta. Tarvitset JavaScript-tuen nähdäksesi sen.. Henkilökohtaiset sähköpostiosoitteet: ...
Resuscitation of marginal hearts using ex vivo perfusion - Northumbria Research LinkResuscitation of marginal hearts using ex vivo perfusion - Northumbria Research Link
Introduction: Increasing the usage of hearts from marginal donors and from donors after circulatory death (DCD) has the potential to expand the donor pool. Such hearts may be resuscitated when subjected to ex vivo perfusion. In addition, this may provide an opportunity for viability testing prior to transplant. We describe a novel ex vivo perfusion system designed to reanimate porcine DCD hearts. The same system was subsequently tested using a human heart from a marginal brainstem-dead donor.. Method: In the first phase of the study 23 porcine hearts were procured following circulatory death. All hearts were subjected to a period of primary warm ischemia followed by 120 minutes of hypothermic preservation. The period of hypothermic preservation was initially static cold storage (SCS); then oxygenated machine perfusion and finally a combination of static cold storage and oxygen persufflation via the coronary sinus. Ex vivo perfusion of the hearts was performed with a normothermic, oxygenated ...
A pathophysiologic study of the kidney tubule to optimize organ preservation solutionsA pathophysiologic study of the kidney tubule to optimize organ preservation solutions
... Background. Tissue damage at the time of organ transplantation has a negative impact on the subsequent success of the procedure, both in the immediate and longer term. Hypothermia is the principal element used to prolong organ viability ex vivo, but paradoxically also induces cellular edema through inhibition of energy-dependent adenosine triphosphatases (ATPases). This induces an electrolyte imbalance that leads to fluid influx and cell swelling. It is important, therefore, that improvements are made in the preservation of ischemic organs to reduce this injury. Methods. This study has applied a novel in vitro system to model cold and warm ischemic-induced renal tubule swelling that characterizes tissue damage in ischemia/reperfusion injury. Biochemical blockade of ATPases in this system using strophanthidin modeled the effects of energy depletion and induced cell swelling. By measuring such tubule swelling ...
Global Organ Preservation Solutions Market Professional Survey Report 2017: By Product, Application, Manufacturer, Sales and...Global Organ Preservation Solutions Market Professional Survey Report 2017: By Product, Application, Manufacturer, Sales and...
The research report titled Global Organ Preservation Solutions Market Professional Survey Report 2017 market size and forecast and overview on current market trends
Donor heart preservation for heart transplantation - Open Research OnlineDonor heart preservation for heart transplantation - Open Research Online
Much attention has been focused on the drama of the surgery and the intricacies of immunological manipulation whilst little effort has been devoted to the area of donor management, despite the fact that primary graft failure is responsible for as many post transplant deaths as either infection or rejection. Optimum preservation of the donor heart has also provided a difficult challenge, such that, despite a considerable scientific effort little advance has been achieved to extend the 4 hour safe storage limit which has remained in place over the past 20 years ...
Liver Preservation with Machine Perfusion under Full Oxygenation Using a New Cell-Free Oxygen-Carrier Solution - ATC AbstractsLiver Preservation with Machine Perfusion under Full Oxygenation Using a New Cell-Free Oxygen-Carrier Solution - ATC Abstracts
Background: Machine perfusion (MP) has been implemented either under hypothermic and anoxic conditions or under normothermia with full oxygenation using blood as perfusate. This is the first pre-clinical large animal series using MP under subnormothermic conditions with a new hemoglobin-based oxygen carrier solution in a dual pressure system for liver preservation. Methods: Two groups of 6 Landrace pigs underwent orthotopic liver transplantation after CIT=9 hours where cold static preservation (CSP) was compared to MP. The MP allografts were continuously perfused by pulsatile and continuous pressures under full oxygenation at 21°C. Both groups had extensive graft and perfusate analysis during the preservation time. The MP group had continuous gasometry of the perfusate and tissue oximetry analysis. Mitochondrial function was analyzed in both groups. All tissues were blindly analyzed through standard histology, immunohistochemistry and electronic microscopy. Results: The CSP group had a ...
Normothermic ex vivo limb perfusion is superior to subnormothermic and hypothermic preservation - A randomised, preclinical...Normothermic ex vivo limb perfusion is superior to subnormothermic and hypothermic preservation - A randomised, preclinical...
Normothermic ex vivo limb perfusion is superior to subnormothermic and hypothermic preservation - A randomised, preclinical transplant study ...
Electrode Storage Solution at Thomas ScientificElectrode Storage Solution at Thomas Scientific
Electrode Storage Solution found in: pH Electrode Storage Solution, PC300 Benchtop pH/Conductivity Meters, Electrode Storage Solution, Electrode Storage..
Novel Lung Trial: Normothermic Ex Vivo Lung Perfusion (Evlp) As An Assessment Of Extended/Marginal Donor Lungs - Full Text View...Novel Lung Trial: Normothermic Ex Vivo Lung Perfusion (Evlp) As An Assessment Of Extended/Marginal Donor Lungs - Full Text View...
These lungs will be brought to the study transplant center to be re-assessed by the transplant team. The lungs will be physiologically assessed during ex vivo perfusion with Steen Solution. Perfusion of these lungs will be performed using Steen solution with the addition of methylprednisolone, heparin and antibiotics. With respect to the decision of lung utilization those organs with a delta pO2 (Δ pO2 = Pulmonary vein pO2 - pulmonary artery pO2) during ex vivo perfusion assessment , 350mmHg, good lung compliance, and a favorable opinion of the transplant surgeon will be considered transplantable. Lungs will be excluded for transplantation: if the Δ pO2 is less than 350mmHg or if they demonstrate ,10% deterioration in any of the following functional parameters: pulmonary vascular resistance (PVR), dynamic compliance or airway pressures. Lungs will also be excluded if they are deemed unsuitable based on the clinical judgment of the lung transplant surgeon ...
Organ Preservation Solutions - Global Market Trajectory & AnalyticsOrgan Preservation Solutions - Global Market Trajectory & Analytics
This report features 7 companies, including Dr. Franz Köhler Chemie GmbH (Germany), Lifeline Scientific, Inc. (USA), Essential Pharmaceuticals, LLC (USA), Preservation Solutions, Inc. (USA)
Recurrent hepatitis C posttransplant: Early preservation injury may predict poor outcome<...Recurrent hepatitis C posttransplant: Early preservation injury may predict poor outcome<...
TY - JOUR. T1 - Recurrent hepatitis C posttransplant. T2 - Early preservation injury may predict poor outcome. AU - Watt, Kymberly D.S.. AU - Lyden, Elizabeth R.. AU - Gulizia, James M.. AU - McCashland, Timothy M.. PY - 2006/1. Y1 - 2006/1. N2 - Organ cold/warm ischemia is thought to be a risk factor for increased severity of recurrence of hepatitis C (HCV) post liver transplantation. We had noted some HCV patients with preservation injury (PI) to have particularly poor outcomes. Our goal was to determine if PI on biopsy in HCV patients is associated with earlier, more rapidly progressive recurrence or graft and patient survival. Sixty-nine patients from the University of Nebraska transplant database were included: 23 HCV patients with PI (group = 1), 23 non-HCV patients with PI (group = 2), and 23 HCV patients without PI (group = 3). Patient groups were matched for gender, age, immunosuppression, and time of transplantation for analysis. No difference in time to recurrence was noted between ...
Food Preservation Techniques - Real Food -MOTHER EARTH NEWSFood Preservation Techniques - Real Food -MOTHER EARTH NEWS
Peruse this collection of articles focused on various food preservation techniques, including drying, canning, pickling, freezing and more.
Storage Solution - Hair Transplant MentorStorage Solution - Hair Transplant Mentor
Storage Solutions are key to your successful hair transplant. Without a storage solution your grafts will die before they are even placed into your scalp!
Patent US5584804 - Brain resuscitation and organ preservation device and method for performing ... - Google PatentsPatent US5584804 - Brain resuscitation and organ preservation device and method for performing ... - Google Patents
The invention discloses methods for preserving organs in brain-dead humans or cadavers which allows additional time for the organs to remain viable such that they may be harvested for subsequent transplantation. This invention also discloses methods for preserving and/or resuscitating organs in live (nonbrain-dead) patients, allowing for additional time to stabilize the patients condition. The methods include the steps of instrumentizing (e.g., catheterizing, cannulating, injecting, etc.) the vessels or tissues around the organ, or the organ itself sought to be preserved and/or resuscitated, the body cavity, or cavities of the body, and introducing a temperature-controlled solution to preserve and/or resuscitate the organ(s). The temperature-controlled organ preservation solution includes components such as oxygen carrying agents, antioxidants, tissue damage reversing and protecting agents, carrier vehicles, diluents, nutrients, and anti-coagulating agents. A device which performs this method is also
Cold ischemia time | Article about cold ischemia time by The Free DictionaryCold ischemia time | Article about cold ischemia time by The Free Dictionary
Looking for cold ischemia time? Find out information about cold ischemia time. sequential arrangement of all events, or the interval between two events in such a sequence. The concept of time may be discussed on several different... Explanation of cold ischemia time
Serval - A new model for human intestinal preservation: comparison of University of Wisconsin and Celsior preservation...Serval - A new model for human intestinal preservation: comparison of University of Wisconsin and Celsior preservation...
AIM: We compared University of Wisconsin (UW) and Celsior preservation solutions using a new model of human intestinal preservation that mimics the clinical conditions of small bowel procurement. METHODS: Intestinal grafts were harvested from four multiorgan donors. After classic warm dissection for organ procurement, an ileal segment of 50 cm was immediately flushed with Celsior. After the perfusion of the abdominal organs with UW, a second segment of adjacent ileum was harvested. The two intestinal grafts were then divided into segments by stapling, before immersion into the corresponding preservation solution (Celsior or UW) for 0-, 6-, 12-, or 24-hour incubation at 4 degrees C. A histological score was graded after blinded examination of three random specimens within each ileal graft for each duration of preservation. RESULTS: Control specimens showed normal histology. After 6 hours of preservation, most villi showed complete epithelial detachment although the crypts appeared intac
Organ Preservation and Resuscitation Laboratory | RIKENOrgan Preservation and Resuscitation Laboratory | RIKEN
Organ transplant surgery has become the principle method to treat patients with dysfunctional organs. However, at present, the biggest hurdle to overcome is the severe shortage of available organs. To expand the supply of healthy donor organs, technological developments based on novel concepts are expected to improve organ preservation and resuscitation. In this project, we aim to develop a novel three-dimensional organ perfusion culture system that allows long-term preservation and resuscitation of severely ischemic organs in in vitro cultures. We hope to contribute to healthcare through the development of a novel technology to expand the supply of available organs.. [Integrated Collaborative Research with SCREEN Holdings Co.,Ltd.]. ...
Lung Transplantation | Profiles RNSLung Transplantation | Profiles RNS
Wagner CE, Pope NH, Charles EJ, Huerter ME, Sharma AK, Salmon MD, Carter BT, Stoler MH, Lau CL, Laubach VE, Kron IL. Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death. J Thorac Cardiovasc Surg. 2016 Feb; 151(2):538-45 ...
Antimicrobial preservation strategies to prevent food contaminationAntimicrobial preservation strategies to prevent food contamination
Food spoiling and poisoning caused by microbial contamination can cause major health, social, and economic problems. The broad scope of antimicrobial approaches to kill or prevent the growth of microorganisms in foods and ...
Ramsys Storage SolutionsRamsys Storage Solutions
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Art Storage, Craft Storage, Art Storage Solutions | MisterArt.com | $5-13Art Storage, Craft Storage, Art Storage Solutions | MisterArt.com | $5-13
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Shop Skinchakra | Electrode storage solution | purchase hereShop Skinchakra | Electrode storage solution | purchase here
Electrode storage solution - KCl, 3M solution stabilised with AgCl Your pH electrodes should never be stored in distilled or tap water, in alcohol or in a product solution. To keep the electrode hydra
Office Storage Solutions, Hospital & Classroom Storage - SteelcaseOffice Storage Solutions, Hospital & Classroom Storage - Steelcase
We offer a variety of storage solutions, from lateral file cabinets for document archiving to bins that will keep office items out of sight.
Storage solutions for private cloud - Hong Kong S.A.R. of China | IBMStorage solutions for private cloud - Hong Kong S.A.R. of China | IBM
IBM storage solutions for IBM Cloud Private-the foundation for a full-platform on-premises hybrid multicloud environment-give you the native cloud acceleration you need to help you build powerful, agile, secure private cloud storage environments.
Small Bathroom Storage Solutions - InfoBarrelSmall Bathroom Storage Solutions - InfoBarrel
Small bathroom storage solutions can plague even the most lavish residence. Space is always at a premium and finding ideas to fit what you need in the room can be a challenge to say the least. Square footage is the issue and making the area work can sometimes...
Storage Solutions: 12 Smart Ways to Save Space at Home | ManCavinStorage Solutions: 12 Smart Ways to Save Space at Home | ManCavin
From maximizing your closet area to using up all the nooks and crannies in your living area, these storage solutions will help you unlock the comfort p...
Cloud Object Storage Solutions - IBM BluemixCloud Object Storage Solutions - IBM Bluemix
Cloud Object Storage Solutions from IBM deliver flexibility, scalability and simplicity required to manage rapidly growing unstructured data in a hybrid cloud environment.
Induction chemotherapy with paclitaxel and cisplatin followed by radiotherapy for larynx organ preservation in advanced...Induction chemotherapy with paclitaxel and cisplatin followed by radiotherapy for larynx organ preservation in advanced...
Induction chemotherapy with paclitaxel and cisplatin followed by radiotherapy for larynx organ preservation in advanced laryngeal and hypopharyngeal cancer offers moderate late toxicity outcome (DeLOS-I-trial) Academic Article ...
Evidence | Ex-situ machine perfusion for extracorporeal preservation of livers for transplantation | Guidance | NICEEvidence | Ex-situ machine perfusion for extracorporeal preservation of livers for transplantation | Guidance | NICE
Evidence-based recommendations on ex-situ machine perfusion for extracorporeal preservation of livers for transplantation in people of all ages
cAMP-mediated vascular protection in an orthotopic rat lung transplant model: Insights into the mechanism of action of...cAMP-mediated vascular protection in an orthotopic rat lung transplant model: Insights into the mechanism of action of...
TY - JOUR. T1 - cAMP-mediated vascular protection in an orthotopic rat lung transplant model. T2 - Insights into the mechanism of action of prostaglandin E1 to improve lung preservation. AU - Naka, Yoshifumi. AU - Roy, Dilip K.. AU - Liao, Hui. AU - Chowdhury, Nepal C.. AU - Michler, Robert E.. AU - Oz, Mehmet C.. AU - Pinsky, David J.. PY - 1996/1/1. Y1 - 1996/1/1. N2 - Prostaglandin E1 (PGE1) is often added to the donor pulmonary flush solution to enhance clinical lung preservation for transplantation. Although PGE1 is thought to act as a pulmonary vasodilator during the harvest period, the precise mechanism(s) of action whereby PGE1 enhances lung preservation is unknown. Because cAMP levels decline in endothelial and vascular smooth muscle cells exposed to hypoxia, we hypothesized that a PGE1-mediated increase in cAMP levels within the preserved lungs might improve pulmonary vascular homeostasis following lung transplantation. Rat lungs demonstrated a time-dependent decline in cAMP levels ...
Land Use Planning and Farmland Preservation Techniques Archives - National Agricultural Law CenterLand Use Planning and Farmland Preservation Techniques Archives - National Agricultural Law Center
Located in Fayetteville, Arkansas, the National Agricultural Law Center serves the nations vast agricultural community and is a key partner of the USDA National Agricultural Library. For more information, click here. Web design and hosting by One Big Kid ...
Upper Limits of Aerobic Power and Performance in Heart Transplant Recipients | CirculationUpper Limits of Aerobic Power and Performance in Heart Transplant Recipients | Circulation
December 3, 2017, marked the 50th anniversary of the first human-to- human heart transplant (HT) surgery, performed by Dr Christiaan Barnard at the Groote Schuur Hospital in Capetown, South Africa. Since this seminal operation, ,124 000 HTs have been performed, and the survival rate has improved significantly (current median survival: 11.9 years) as a result of refinements in donor and recipient selection, advances in surgical techniques, organ preservation strategies, and immunosuppressive therapy.. Despite improvement or normalization of left ventricular systolic function, HT recipients (HTRs) typically have a peak aerobic power (peak Vo2) that is ≈40% lower than age- and activity-matched healthy people.1 Persistent impairment of peak Vo2 following HT is multifactorial with contributions from abnormal skeletal muscle function associated with pre-HT heart failure (HF), bedrest deconditioning associated with prolonged hospitalization, posttransplant cardiac allograft denervation, and ...
Life 4°C Versus Optisol in Corneal Storage Media - Full Text View - ClinicalTrials.govLife 4°C Versus Optisol in Corneal Storage Media - Full Text View - ClinicalTrials.gov
The purpose of this study is to compare the success of storing a donor cornea in Optisol GS, the current standard vs. storing the donor cornea in Life4°C, a newer solution. The donor cornea to be used for EK will be provided by an eye bank and will have been stored in either an Optisol GS solution or a Life 4°C solution. At 6 months, the doctors will determine whether there are any comparable differences in cell loss and graft clarity between the two donor corneas ...
Market Design: Organ preservation could bring big changes to transplantationMarket Design: Organ preservation could bring big changes to transplantation
Abstract: The ability to replace organs and tissues on demand could save or improve millions of lives each year globally and create public health benefits on par with curing cancer. Unmet needs for organ and tissue preservation place enormous logistical limitations on transplantation, regenerative medicine, drug discovery, and a variety of rapidly advancing areas spanning biomedicine. A growing coalition of researchers, clinicians, advocacy organizations, academic institutions, and other stakeholders has assembled to address the unmet need for preservation advances, outlining remaining challenges and identifying areas of underinvestment and untapped opportunities. Meanwhile, recent discoveries provide proofs of principle for breakthroughs in a family of research areas surrounding biopreservation. These developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation ...
Cold storage wallet cryptocurrency - Cryptocurrency exchange wallet feeCold storage wallet cryptocurrency - Cryptocurrency exchange wallet fee
Cold storage wallet cryptocurrency. . Based on the storage method, we can group cryptocurrency wallets into two categories- cold wallets (which uses cold storage) and hot wallets. trading-news.site: Seedsafe Cryptocurrency Seed Storage Safe - Cold Storage Wallet Backup - Compatible with Ledger, Trezor, KeepKey Hardware Wallets, Cold.. future of ltc cryptocurrency.
WATERS IGL® PULSATILE PERFUSION SOLUTION - Waters Medical SystemsWATERS IGL® PULSATILE PERFUSION SOLUTION - Waters Medical Systems
WATERS IGL® Pulsatile Perfusion Solution has a calculated potassium concentration of 25 mEq/L, a sodium concentration of 100 mEq/L, an osmolarity of 300 mOsM, and a pH of 7.4 at room temperature. Its ion composition is comparable with that of the intracellular milieu. ...
Community Academic Profiles - Faculty & Researchers - Stanford MedicineCommunity Academic Profiles - Faculty & Researchers - Stanford Medicine
Current Research and Scholarly Interests Methods of evaluation of biopsies; differentiation and, classification of neoplasms; immunohistochemistry; scanning and, transmission electron microscopy; cardiovascular pathology;, histologic assessment of bone biopsies; heart preservation and, restoration; myocardial biopsies; venous autograft coronary artery, bypass; cardial and heart valve transplantation. ...
Uncategorized | Look Like An AthleteUncategorized | Look Like An Athlete
It has been proven scientifically that beef jerky can help you build strong muscles. Beef jerky refers to strips of dried beef that are mostly consumed as snacks. High in proteins and low in fat content, beef jerky is a favorite among athletes and body-builders. If building lithe muscles is your objective, then beef jerky is a part of every shopping list you create.. Beef jerky started out as a means of increasing the preservation period of meat during an era when refrigerators were not yet available to hunters. The beneficial effects of dried beef did not go unnoticed, and nutritionists lost no time in identifying what makes beef jerky the health food that it is.. Beef jerky is important for body builders as it is packed with proteins and iron, but is low on fat. The preparation of beef jerky is a process that sucks out moisture and fats. An ounce of beef jerky contains about 15g of protein, almost twice the amount of the mineral in pork. Vitamins, or amino acids, are the building blocks of ...
ASCO larynx-preservation guidelines reflect important practice changes | ACS Surgery NewsASCO larynx-preservation guidelines reflect important practice changes | ACS Surgery News
The latest edition of the clinical practice guideline on larynx preservation strategies for the treatment of laryngeal cancer from the American Society of Clini
Laboratory Storage Solutions: Efficient Solutions to the Ever Present Issue of StuffLaboratory Storage Solutions: Efficient Solutions to the Ever Present Issue of Stuff
What options exist to better store items that not only provide more storage but also provide an economy of space? Depending on what is being stored there are a number of products to help facilitate that need.
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OdooTools is the team of developers and business analysts to help you extend Odoo potential. We have been communicating with end users to whom the software became the main business tool since 2012. As a result, we are proud of dozens of successful Odoo apps developed. We are open for new ideas and challenges to create the best Odoo tools for business needs all over the world. This tool has been developed in cooperation with IT Libertas - one of the leading Odoo integrators in Russia. ...
OWC Mercury Elite Pro 1TB Storage SolutionOWC Mercury Elite Pro 1TB Storage Solution
Offers (1) USB 3.1 Gen 1 (backward compatible with USB 2.0/1.1), (2) FireWire 800(1394B), and (1) eSATA ports for easy Plug and Play on any system.
The Fair Organ Preservation Society Discussion Forum • View topic - new home required for part made small organThe Fair Organ Preservation Society Discussion Forum • View topic - new home required for part made small organ
A friend has bequeathed us a small (sideboard sized) part built organ. It has a case (plain wood) boxes of carefully made wooden pipes and some of the plans required to complete the task. We would like to find an enthusiast who would like to take the project forward. We live in Lancashire, Uk, so someone local(ish) would be ideal and would save on cost of delivery / collection. We would appreciate a token payment for the organ, but that is not as important to us as not seeing our friends work wasted. contact via email ...
The Fair Organ Preservation Society Discussion Forum • View topic - YouTube video embeddingThe Fair Organ Preservation Society Discussion Forum • View topic - YouTube video embedding
In the post editor, you will see a youtube button above the message window, underneath the Font size: setting. Simply enter the URL (address) of the video, for example ...
Influence of CpG-dinucleotide motifs on the duration of gene expression from plasmid, vectors after in vivo lung delivery - ORA...Influence of CpG-dinucleotide motifs on the duration of gene expression from plasmid, vectors after in vivo lung delivery - ORA...
Gill, D. R., Lawton, A. E., Pringle, I. A., Davies, L. A., Yew, N. S., Cheng, S. H., & Hyde, S. C. (2007). Influence of CpG-dinucleotide motifs on the duration of gene expression from plasmid, vectors after in vivo lung delivery. PEDIATRIC PULMONOLOGY, 307-307 ...
KAKEN - Research Projects | Investigation of the usefulness of pentoxifylline for liver preservation (KAKENHI-PROJECT-08671387)KAKEN - Research Projects | Investigation of the usefulness of pentoxifylline for liver preservation (KAKENHI-PROJECT-08671387)
Principal Investigator：KOZAKI Koichi, Project Period (FY)：1996 - 1998, Research Category：Grant-in-Aid for Scientific Research (C), Section：一般, Research Field：General surgery
How to insulate on a cold storage roomHow to insulate on a cold storage room
I have a cold storage room underneath my front porch. It is poured out of concrete. It is around 20 long wide by 5 feet Wide. We dont use it at all for cold storage, but want to use it for regular storage year round. Obviously it is very cold in there during the winter.
Cannon Preservation Ltd: 100% Feedback, Damp Proofing Specialist in ColchesterCannon Preservation Ltd: 100% Feedback, Damp Proofing Specialist in Colchester
Specialist Building Guarantees Ltd Damp Proofing,Dry Rot Control,WoodwormTreatments,TimberPreservation, Basement Waterproofing, Cavity drainage membrane systems, Timber Repairs/Renewal, whether it be Joist replacement/bolt on or a new timber floor.. Condensation control using Heat recovery units and Mould cleaning services are also offered.. Cannon Preservation Ltd is a member of Specialist Building Guarantees Ltd, offering 10 year guarantees for Damp proofing,Timber preservation/Woodworm treatments and Cavity wall ties.. Cannon Preservation Ltd also offer 10 year guarantees for structural waterproofing, provided by Specialist Building Guarantees Ltd.. Cannon Preservation Ltd is a member of the Buy With Confidence and Norfolk Trusted Traders, both being government backed with the agreement to provide a professional,well priced and quality service.. ...
Index of oral health and dental articlesIndex of oral health and dental articles
Viability assayViability assay
Machine perfusionMachine perfusion
J. W. Walker & Sons LtdJ. W. Walker & Sons Ltd
Washington National CathedralWashington National Cathedral
St. Joseph Cathedral (Buffalo, New York)St. Joseph Cathedral (Buffalo, New York)
Greg FahyGreg Fahy
21st Century Medicine21st Century Medicine
Histidine-tryptophan-ketoglutarateHistidine-tryptophan-ketoglutarate
Kidney Paired DonationKidney Paired Donation
Cell damageCell damage
Holy Trinity Episcopal Church (Spring Lake, New Jersey)Holy Trinity Episcopal Church (Spring Lake, New Jersey)
Fonthill Castle and the Administration Building of the College of Mount St. VincentFonthill Castle and the Administration Building of the College of Mount St. Vincent
LaryngectomyLaryngectomy
Thomas StarzlThomas Starzl
Patriot Youth League of SwedenPatriot Youth League of Sweden
Roger GosdenRoger Gosden
St. Marks Episcopal Church (Hope, Arkansas)St. Mark's Episcopal Church (Hope, Arkansas)
Trinity Episcopal Church (Houghton, Michigan)Trinity Episcopal Church (Houghton, Michigan)
First Unitarian Church of OmahaFirst Unitarian Church of Omaha
Yashoda HospitalsYashoda Hospitals
Intestine transplantationIntestine transplantation
Interaural time differenceInteraural time difference
SupercoolingSupercooling
Cincinnati Music HallCincinnati Music Hall
Hilbert Circle TheatreHilbert Circle Theatre
Gjerpen ChurchGjerpen Church
Evolution of cephalopodsEvolution of cephalopods
Brendan PowerBrendan Power
BarnacleBarnacle
MedicineMedicine
NephrologyNephrology
BiofuelBiofuel
StroudStroud
Cilmes šūna - VikipēdijaCilmes šūna - Vikipēdija
California condorCalifornia condor
Romani peopleRomani people
Giacomo PucciniGiacomo Puccini
PaleontologyPaleontology
Radiation therapyRadiation therapy
Calorie restrictionCalorie restriction
Molecular gastronomyMolecular gastronomy
Food allergyFood allergy
ProbioticProbiotic
SpruceSpruce
Eye neoplasmEye neoplasm
Dead on arrivalDead on arrival
IgA nephropathyIgA nephropathy
سرطان پروستات - ویکی‌پدیا، دانشنامهٔ آزادسرطان پروستات - ویکی‌پدیا، دانشنامهٔ آزاد
AngamporaAngampora
Electric Dylan controversyElectric Dylan controversy
FinFin
FlowerFlower
Hepatorenal syndromeHepatorenal syndrome
ChemotherapyChemotherapy
Kamieninė ląstelė - VikipedijaKamieninė ląstelė - Vikipedija
CryoprotectantCryoprotectant
Common descentCommon descent
AnnelidAnnelid
AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Organ PreservationOrgan Preservation SolutionsLaryngectomyRaffinoseLaryngeal NeoplasmsHypopharyngeal NeoplasmsAllopurinolPharyngectomyCarcinoma, Squamous CellBrain DeathHead and Neck NeoplasmsCombined Modality TherapyPreservation, BiologicalPancreas TransplantationCryopreservationFluorouracilCisplatinMannitolFertility PreservationReperfusion InjuryPerfusionLiver TransplantationRadiotherapy, AdjuvantGraft SurvivalTissue DonorsHydroxyureaTreatment OutcomeAntineoplastic Combined Chemotherapy ProtocolsRadiotherapy DosageAdenosineInsurance, Health, ReimbursementGlutathioneSalvage TherapyNeoplasm StagingKidney TransplantationGraft RejectionSurvival AnalysisTissue and Organ ProcurementOrgan TransplantationLiverSurvival RateRetrospective StudiesFollow-Up StudiesCyclic Nucleotide Phosphodiesterases, Type 3Semen PreservationFood PreservationMultiple Organ FailureOrgan SizeOrgan SpecificityOrgan of CortiCold IschemiaFreeze DryingTime FactorsBlood Preservation
Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver - Zurich Open...Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver - Zurich Open...
Organ Preservation Market, Size, Share, Outlook and Growth Opportunities 2019-2026Organ Preservation Market, Size, Share, Outlook and Growth Opportunities 2019-2026
Organ Reperfusion & Preservation - Paragonix TechnologiesOrgan Reperfusion & Preservation - Paragonix Technologies
Hypothermic Machine Perfusion in Kidney Transplantation: Back to the Future? | OMICS InternationalHypothermic Machine Perfusion in Kidney Transplantation: Back to the Future? | OMICS International
Positive cultures of organ preservation fluid predict postoperative infections in solid organ transplantation recipients |...Positive cultures of organ preservation fluid predict postoperative infections in solid organ transplantation recipients |...
KAKEN - Research Projects | The experimental study of long-term heart preservation with the combined method of simple immersion...KAKEN - Research Projects | The experimental study of long-term heart preservation with the combined method of simple immersion...
British Library EThOS: Strategies for normothermic preservation of liversBritish Library EThOS: Strategies for normothermic preservation of livers
Global Hypothermic Machine Perfusion Preservation Sales Market Report 2021 : ReportsnReportsGlobal Hypothermic Machine Perfusion Preservation Sales Market Report 2021 : ReportsnReports
Perfusion preservation solution for recovery of Donation by Cardiac Death livers | SBIR.govPerfusion preservation solution for recovery of Donation by Cardiac Death livers | SBIR.gov
ScubaTx organ preservation device - Press Office - Newcastle UniversityScubaTx organ preservation device - Press Office - Newcastle University
Organ Preservation Solutions Market: TechnologicalOrgan Preservation Solutions Market: Technological
Machine preservation may promote more organ sharing | EurekAlert! Science NewsMachine preservation may promote more organ sharing | EurekAlert! Science News
Oxygenated Preservation Solutions for Organ Preservation : TransplantationOxygenated Preservation Solutions for Organ Preservation : Transplantation
Machine Preservation May Promote More Organ Sharing | MedgadgetMachine Preservation May Promote More Organ Sharing | Medgadget
Organ Preservation and Resuscitation Laboratory | RIKENOrgan Preservation and Resuscitation Laboratory | RIKEN
New machine-perfusion organ preservation system keeps livers healthier for transplant | EurekAlert! Science NewsNew machine-perfusion organ preservation system keeps livers healthier for transplant | EurekAlert! Science News
Organ Preservation: Overview, Pathophysiology of Organ Preservation, Preservation Solutions and Their PharmacologyOrgan Preservation: Overview, Pathophysiology of Organ Preservation, Preservation Solutions and Their Pharmacology
Organ Preservation Market worth $284 million by 2024Organ Preservation Market worth $284 million by 2024
Bridge to Life and Tevosol Merge to Commercialize Portable Normothermic Machine Preservation Technology Platform for Organ...Bridge to Life and Tevosol Merge to Commercialize Portable Normothermic Machine Preservation Technology Platform for Organ...
organ preservation Protocols and Video...'organ preservation' Protocols and Video...
Patent US3843455 - Apparatus and technique for preservation of isolated organs through perfusion - Google PatentsPatent US3843455 - Apparatus and technique for preservation of isolated organs through perfusion - Google Patents
Patent US5584804 - Brain resuscitation and organ preservation device and method for performing ... - Google PatentsPatent US5584804 - Brain resuscitation and organ preservation device and method for performing ... - Google Patents
Organ Preservation Solutions - Global Market Trajectory & AnalyticsOrgan Preservation Solutions - Global Market Trajectory & Analytics
Organ Preservation in Treatment of Head and Neck Cancers | Frontiers Research TopicOrgan Preservation in Treatment of Head and Neck Cancers | Frontiers Research Topic
Organ Preservation Solutions Market Report 2021-2031 - VisiongainOrgan Preservation Solutions Market Report 2021-2031 - Visiongain
Optimization of SDS exposure on preservation of ECM characteristics in whole organ decellularization of rat kidneys. - PubMed ...Optimization of SDS exposure on preservation of ECM characteristics in whole organ decellularization of rat kidneys. - PubMed ...
Human heart beats on its own outside body during test of new organ preservation systemHuman heart beats on its own outside body during test of new organ preservation system
PEROXISOME-PROLIFERATOR ACTIVATED RECEPTOR-ALPHA AGONISTS FOR ORGAN PRESERVATION - University of Pittsburgh of the Commonwealth...PEROXISOME-PROLIFERATOR ACTIVATED RECEPTOR-ALPHA AGONISTS FOR ORGAN PRESERVATION - University of Pittsburgh of the Commonwealth...
A New Surgical Method of Suprapubic and Extraperitoneal Approach with Uterine Preservation for Pelvic Organ Prolapse: Kurt...A New Surgical Method of Suprapubic and Extraperitoneal Approach with Uterine Preservation for Pelvic Organ Prolapse: Kurt...
A pathophysiologic study of the kidney tubule to optimize organ preservation solutionsA pathophysiologic study of the kidney tubule to optimize organ preservation solutions
The Fair Organ Preservation Society Discussion Forum • Frequently Asked QuestionsThe Fair Organ Preservation Society Discussion Forum • Frequently Asked Questions
Global Organ Preservation Market is poised to touch USD 262 million by 2021Global Organ Preservation Market is poised to touch USD 262 million by 2021
Organ Transplantation Market Growth Analysis, Trends and Forecast by 2025| Terumo Medical Corporation, Preservation Solutions,...Organ Transplantation Market Growth Analysis, Trends and Forecast by 2025| Terumo Medical Corporation, Preservation Solutions,...
The Fair Organ Preservation Society Discussion Forum • View topic - Help neededThe Fair Organ Preservation Society Discussion Forum • View topic - Help needed
Discovery could open door to frozen preservation of tissues, whole organsDiscovery could open door to frozen preservation of tissues, whole organs
Perfluorocarbon for organ preservation before transplantation. - Semantic ScholarPerfluorocarbon for organ preservation before transplantation. - Semantic Scholar
Long‐Term Experience of Chemoradiotherapy Combined with Deep Regional Hyperthermia for Organ Preservation in High‐Risk Bladder...Long‐Term Experience of Chemoradiotherapy Combined with Deep Regional Hyperthermia for Organ Preservation in High‐Risk Bladder...
Cultural Heritage and Preservation - Göteborg Organ Art Center, University of Gothenburg, Sweden ...Cultural Heritage and Preservation - Göteborg Organ Art Center, University of Gothenburg, Sweden ...
Transplantation Market By Product (Tissue Products, Immunosuppressive Drugs, Preservation Solutions), By Application (Organ,...Transplantation Market By Product (Tissue Products, Immunosuppressive Drugs, Preservation Solutions), By Application (Organ,...
AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Organ PreservationOrgan Preservation SolutionsLaryngectomyRaffinoseLaryngeal NeoplasmsHypopharyngeal NeoplasmsAllopurinolPharyngectomyCarcinoma, Squamous CellBrain DeathHead and Neck NeoplasmsCombined Modality TherapyPreservation, BiologicalPancreas TransplantationCryopreservationFluorouracilCisplatinMannitolFertility PreservationReperfusion InjuryPerfusionLiver TransplantationRadiotherapy, AdjuvantGraft SurvivalTissue DonorsHydroxyureaTreatment OutcomeAntineoplastic Combined Chemotherapy ProtocolsRadiotherapy DosageAdenosineInsurance, Health, ReimbursementGlutathioneSalvage TherapyNeoplasm StagingKidney TransplantationGraft RejectionSurvival AnalysisTissue and Organ ProcurementOrgan TransplantationLiverSurvival RateRetrospective StudiesFollow-Up StudiesCyclic Nucleotide Phosphodiesterases, Type 3Semen PreservationFood PreservationMultiple Organ FailureOrgan SizeOrgan SpecificityOrgan of CortiCold IschemiaFreeze DryingTime FactorsBlood Preservation
TransplantationLiversDonorsHypothermic perfusion preservationCardiacNormothermic machine perfusionTransplantPerfusion preservationPancreasDonationPhysiologicalClinicalKidney transplantsNorth America2019ImplantationStatic cold storagePoor preservationHeart preservationMachineOptimalFunctionTypePerfusionKidneysTransplantsKidneyViabilityHypothermic preservationLungs20202018CentersCAGRCustodiol HTKProcurementGraftsSolutionLarynxTechniqueHypothermiaIschemic organsLaryngealForecastMethodsSegmentAdvancementsSolutionsCold preservationPlayers in the organ preservation marketViableSupply of available organsSolid organResuscitationTemperatureSurgicalDemand for organs farDonor organRecipientsDifferent organsChemoradiationDonation after circulatory
Transplantation14
Livers1
  • This project will form the basis for further testing in a Phase II SBIR application for recovery and preservation of extended warm ischemic livers in a pre-clinical animal transplant model. (sbir.gov)
Donors2
Hypothermic perfusion preservation2
Cardiac1
Normothermic machine perfusion2
Transplant2
  • Impressive advances in organ procurement, surgical technique, post-operative care, and immunosuppression have significantly reduced transplant-related morbidity and mortality transforming an extraordinary event in a safe and routinely performed procedure. (omicsonline.org)
  • Publications] Hasegawa Y, et al: 'Effect of short-term coronary perfusion after cold strage for long-term heart preservation : A comparative study of University of Wisconsin solution and diluted blood as the perfusate' Transplant Proc. (nii.ac.jp)
Perfusion preservation1
  • In addition, we designed an original apparatus for continuous coronary perfusion preservation instead of the Langendorff's method This apparatus has such characteristics as hypothermic management, variable perfusion pressure, non-dependent energy source and portable. (nii.ac.jp)
Pancreas1
Donation1
  • Other factors such as the growing government and NGO initiatives to encourage organ donation along with the increasing awareness of organ donations assist the market development. (datamintelligence.com)
Physiological1
Clinical2
  • NTG similarly enhanced preservation of hearts stored in University of Wisconsin solution, the clinical standard for preservation. (jci.org)
  • Incorporating these features in a system based on existing standard surgical and organ sharing procedures and which is able to work stand-alone for 24 h, weighing less than 23 kg, could successfully implement this technique into every day clinical practise. (ox.ac.uk)
Kidney transplants1
  • According to the National Kidney Foundation, in 2016, around 121,678 people are waiting for lifesaving organ transplants in the U.S., among which, approximately 100,791 people are waiting for kidney transplants. (datamintelligence.com)
North America1
  • North America dominates the global Organ Preservation Market, and it is primarily attributed to the rising geriatric population leading to the higher occurrence of organ failures. (datamintelligence.com)
20191
  • The Global Organ Preservation Market is expected to grow at a high CAGR during the forecasting period (2019-2026). (datamintelligence.com)
Implantation2
Static cold storage2
Poor preservation2
  • Other stimulators of the NO pathway, including nitroprusside, L-arginine, or 8-bromoguanosine 3',5' monophosphate, also enhanced graft survival, whereas the competitive NO synthase antagonist NG-monomethyl-L-arginine was associated with poor preservation. (jci.org)
  • However, they are largely under utilized due to poor preservation by the current method of simple cold storage (SCS). (sbir.gov)
Heart preservation4
  • We are now planning the evaluation of transplanted hearts by the force transducer and long-term heart preservation of more than 12-hr. (nii.ac.jp)
  • Publications] Ogiwara H, et al: 'A comparison of the University of Wisconsin and the modified Kawakami solution for initial flush and coronary perfusion in long-term canine heart preservation. (nii.ac.jp)
  • Long-term heart preservation by the combined method of simple immersion and coronary perfusion. (nii.ac.jp)
  • The effect of initial flush for cooling and coronary vascular washout in heart preservation. (nii.ac.jp)
Machine1
Optimal1
Function1
  • This system can assess whether grafts experience primary non-function, a major cause of failure in DCD organs. (sbir.gov)
Type1
Perfusion37
Kidneys18
Transplants21
Kidney16
  • While the ScubaTx device will be compatible with multiple organ types, the initial clinical focus will be on pancreas and kidney. (ncl.ac.uk)
  • Rise in incidences of organ failure in kidney, liver and heart patients across the globe is augmenting the demand for organ transplant procedures. (openpr.com)
  • Moreover, rising incidences of kidney, liver and other organ failure drives the need of transplant surgeries and increase the demand of organ preservation solutions in the market. (openpr.com)
  • This article discusses the pathophysiology, techniques, and principles of organ preservation, and idescribes various preservation solutions currently used for kidney , liver , pancreas , small-bowel , lung , and heart transplantations. (medscape.com)
  • By Organ type, Kidney holds the largest market share and lungs is expected to grow at the highest CAGR in the forecast period. (marketsandmarkets.com)
  • The machine had already been tested using a human kidney and animal organs. (newson6.com)
  • The first human organ to be connected to the machine was a kidney, which was kept functioning for almost 24 hours in a test this summer at the University of Chicago. (newson6.com)
  • 10. The method of claim 1 or 6, wherein the organ is kidney, liver, heart, skin and lung. (freepatentsonline.com)
  • 11. The method of claim 1 or 6, wherein the organ is a kidney. (freepatentsonline.com)
  • Preservation of kidney accounted for the biggest market share in 2016 owing to the increasing aging population coupled with increasing prevalence of kidney failures. (comunicati.net)
  • Kidney preservation holds the most significant share in the organ preservation market due to the rising elderly population coupled with the rise in the occurrence of kidney failures. (datamintelligence.com)
  • The growing prevalence of cardiovascular diseases and the increasing cases of kidney failure are likely to enhance the growth of organ preservation. (datamintelligence.com)
  • The aim of this study was to compare these preservation methods on kidney graft outcomes. (biomedcentral.com)
  • Rising prevalence of chronic kidney & heart disease, augmented number of end stage organ failure, chronic obstructive pulmonary disease (COPD) across the globe, technological advancements in organ preservation supply chain coupled with the rising demand for healthcare products are the major factors impelling the market growth. (todayinscience.com)
  • Factors such as enhanced healthcare spending, rising geriatric population, practice of unhealthy lifestyle & lack of physical inactivity, consumption of alcohol, smoking tobacco and excessive exposure to polluted environment are the crucial factors that develop chronic kidney, heart and lung diseases are supposed to augment the demand for organ preservation products and services. (todayinscience.com)
  • On the basis of Organ Type, Kidney held the largest market share during the historical period. (todayinscience.com)
Viability12
  • The technique, persufflation, submerges donor organs in saline solution and gently streams oxygenated air through the vessels of the chilled organs to increase viability from just a few hours to 24 hours or longer. (ncl.ac.uk)
  • This solutions maintains organ viability, rapidly cool down the organ and minimizes cellular injury. (openpr.com)
  • it is a superior means of preserving organs out of body and provides a way to assess the viability of the organ. (eurekalert.org)
  • In previous studies with up to four years of follow-up data, Stratta has shown that success rates with these organs are equivalent to those of conventional donors, in part because of appropriate donor and recipient matching through using the pump to assess viability and function. (eurekalert.org)
  • Maintaining organ viability during preservation is an important factor for a successful outcome. (lww.com)
  • One component essential for tissue viability that is absent from current cold static preservation methods is tissue oxygenation. (lww.com)
  • Hypothermia is the principal element used to prolong organ viability ex vivo, but paradoxically also induces cellular edema through inhibition of energy-dependent adenosine triphosphatases (ATPases). (ebscohost.com)
  • We demonstrate that the strategy effectively maintained cell viability, transcriptome integrity, cell population heterogeneity, and transcriptome landscape stability for samples after up to 3 days of preservation. (biomedcentral.com)
  • Traditional static cold preservation cannot prevent ischemia/reperfusion injury, the low temperature itself is damaging and viability testing is limited. (ox.ac.uk)
  • Indeed, the rodent organs stored at -4°C (under moderate pressure) were of comparable viability to those stored at 0°C (at atmospheric pressure) and there was significant injury at the lowest temperatures (under the highest pressures). (organpreservationalliance.org)
  • The duration of ex vivo reperfusion should be specified to allow adequate assessment of organ function and viability. (wolterskluwer.com)
  • Preservation of organs for much longer than 4C6 h leads to increased ROS amounts, ATP depletion, Na+/K+ ATPase modifications, mitochondrial disturbances, deposition of xanthine oxidase, and dysregulation of Ca2+ homeostasis which will impact mobile viability [2 adversely, (az628.com)
Hypothermic preservation2
Lungs2
20208
  • Amid the COVID-19 crisis, the global market for Organ Preservation Solutions estimated at US$195.6 Million in the year 2020, is projected to reach a revised size of US$305.9 Million by 2027, growing at a CAGR of 6.6% over the analysis period 2020-2027. (researchandmarkets.com)
  • The Organ Preservation Solutions market in the U.S. is estimated at US$57.8 Million in the year 2020. (researchandmarkets.com)
  • Paragonix in January 2020 announced the clearance of a Pre-Marketing Notification (510(k) with the U.S. Food and Drug Administration (FDA) for the Donor Lung Preservation System (LUNGguard). (reportsanddata.com)
  • Global Organ Preservation Solution Market Report 2020 by Key Players, Types, App. (marketstudyreport.com)
  • The Organ Preservation Solution market is expected to grow from USD X.X million in 2020 to USD X.X million by 2026, at a CAGR of X.X% during the forecast period. (marketstudyreport.com)
  • In the report, Organ Preservation market's revenue is estimated at USD XX million in 2020 and is expected to reach USD XX million by the end of 2028, rising at a CAGR of XX percent. (fusionscienceacademy.com)
  • WiseGuyReports.com adds "Global Organ Preservation Market Research Report 2020 Analysis and Forecast 2025" reports to its database. (todayinscience.com)
  • Further, rising geriatric population, hypertension, unhealthy lifestyle and increasing government initiatives creating awareness and importance of organ donation are some of the factors driving the market and anticipated to infuse growth in the market for Organ Preservation during the forecast period of 2020-2025. (todayinscience.com)
20184
  • According to the report, the global Organ Preservation Solutions Market was valued at US$ 193.4 Mn in 2018 and is projected to expand at a CAGR of 10.5% from 2019 to 2027. (openpr.com)
  • Europe dominated the global organ preservation solutions market in 2018 and the trend is anticipated to continue during the forecast period. (openpr.com)
  • The Custodial HTK segment held major share of the global organ preservation solutions market in 2018 and the trend is anticipated to continue during the forecast period. (openpr.com)
  • Europe dominated the global organ preservation solutions market in 2018, followed by North America. (openpr.com)
Centers4
CAGR5
  • Asia Pacific is likely to be a highly lucrative market for organ preservation solution expected to expand at a high CAGR during the forecast period. (openpr.com)
  • The Global Organ Preservation Market is worth USD 180 million in 2016 and estimated to grow at a CAGR of 7.8%, to reach USD 262 million by 2021. (comunicati.net)
  • AsiaNewsWire.Net , July 17, 2017 ) According to Publisher, the Global Organ Preservation market is estimated at $153.93 million in 2015 and is expected to reach $274.19 million by 2022 growing at a CAGR of 8.7% from 2015 to 2022. (asianewswire.net)
  • Europe is the largest market for Organ Preservation and Asia Pacific is anticipated to register significant CAGR during the forecast period. (asianewswire.net)
  • However, demand for lung preservation is estimated to grow with highest CAGR owing to increasing incidence of having Chronic Obstructive Pulmonary Disease and other life-threatening lung diseases in large number of people across all the regions. (todayinscience.com)
Custodiol HTK2
Procurement6
Grafts3
Solution31
Larynx6
  • New selection criteria for better larynx organ preservation according to the DeLOS-II trial. (frontiersin.org)
  • Transoral laser microsurgery (TLM) for organ preservation in larynx/hypopharynx cancer. (frontiersin.org)
  • With a median follow-up time of 3 years, the estimated larynx preservation rate was 70.3 percent in the TPF-treated patients and 57.5 percent in the PF-treated patients. (esciencenews.com)
  • However, they caution that "Because we proposed treatment to a select popula¬tion of patients with only larynx and hypopharynx cancer and this trial was especially designed for organ preservation, we cannot gen¬eralize the findings to all locally advanced head and neck cancers. (esciencenews.com)
  • Raol N, Hutcheson KA, Lewin JS, Kupferman ME (2013) Surgical Management of the Non-functional Larynx after Organ Preservation Therapy. (scitechnol.com)
  • The results of the VA study demonstrated that a strategy of induction chemotherapy followed by definitive radiation therapy was an effective approach for larynx preservation without compromising a patient's overall survival compared to total laryngectomy. (appliedradiationoncology.com)
Technique4
Hypothermia3
  • They comprised an organ-holding chamber, pulsatile pump for circulation of the perfusate, means of maintaining hypothermia, and several controls. (google.com.au)
  • BACKGROUND: Hypothermia-induced changes in endothelial cell (EC) morphology and function after organ storage may influence the initial outcome and development of transplant-associated coronary artery disease. (uni-regensburg.de)
  • Creating hypothermia by reducing the organ temperature may help preservation, but different body organs need precise and appropriate storage environments to maintain their anatomical and physiological processes. (datamintelligence.com)
Ischemic organs1
Laryngeal3
Forecast2
Methods6
  • This invention also discloses methods for preserving and/or resuscitating organs in live. (google.com.au)
  • This invention also discloses methods for preserving and/or resuscitating organs in live (nonbrain-dead) patients, allowing for additional time to stabilize the patient's condition. (google.com.au)
  • Methods and compositions for reducing, preventing or reversing organ damage and/or enhancing organ preservation by administration of a peroxisome-proliferator activated receptor-alpha (PPARα) agonist to the organ. (freepatentsonline.com)
  • METHODS: In a pig liver transplant model, we compared the outcome following either conventional cold preservation or warm preservation. (ox.ac.uk)
  • Our unique combination of primary and secondary research methods has helped us spot hidden business opportunities on the global organ preservation market, in addition to collecting significant market participant's perspectives and reliable market data. (fusionscienceacademy.com)
  • Now in its thoroughly revised, updated Fifth Edition, this volume is a comprehensive, practical reference on contemporary methods of disinfection, sterilization, and preservation and their medical, surgical, and public health applications. (google.com)
Segment1
  • The report also includes profiles and for some of the leading companies in the Organ Preservation Solutions Market, with a focus on this segment of these companies' operations. (visiongain.com)
Advancements2
Solutions17
Cold preservation2
Players in the organ preservation market1
  • The report provides a list of all the key players in the organ preservation market along with a detailed analysis of the strategies that are being implemented by the companies. (fusionscienceacademy.com)
Viable2
  • The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism). (jove.com)
  • It is for this reason that techniques and instruments were developed for the preservation of viable organs. (google.com.au)
Supply of available organs2
  • We hope to contribute to healthcare through the development of a novel technology to expand the supply of available organs. (riken.jp)
  • The growth in the number of patients wanting or waiting for a transplant has outpaced the supply of available organs. (medscape.com)
Solid organ1
  • Most solid-organ transplantations are now performed as the therapeutic option of choice. (medscape.com)
Resuscitation1
Temperature3
  • Hypothermic temperature effects on organ survival and restoration. (riken.jp)
  • The organ is perfused with a plasma or plasma derivative containing fluid at low temperature, with the organ being contained in a chamber which functions at the same time as the oxygenator for the oxygenation of the perfusate. (google.com.au)
  • The temperature-controlled hot air procedure is used to destroy insect pests in organ parts, wooden objects or furniture by gradually heating them to 55°C in a controlled process. (orgelbau-krawinkel.com)
Surgical4
  • Moreover the interdisciplinary concepts changed to more personalized compositions and without neglecting the strong evidence of non-surgical multimodality treatment approaches, surgery as a centre discipline in organ preservation is gaining relevance according to rising popularity of transoral access due to new IT and engineering developments. (frontiersin.org)
  • Surgical organ preservation in oropharynx carcinoma. (frontiersin.org)
  • It is divided into three main sections: Organ Preservation, Organ Harvesting and Surgical Techniques. (taylorfrancis.com)
  • Other criteria are needed to identify patients most likely to benefit from early surgical resection/salvage after organ preservation. (duke.edu)
Demand for organs far1
  • yet despite best efforts, demand for organs far outstrips supply. (ncl.ac.uk)
Donor organ3
  • Hyperacute rejection occurs when the patient's body has already produced a large number of antibodies (proteins manufactured by the immune system to battle disease and infection) that immediately recognize the antigens from the donor organ. (jrank.org)
  • As the immune system initiates a response to the antigens in the donor organ, specific immune cells in the blood begin to attack. (jrank.org)
  • Although this type of rejection is rare, when it occurs, the donor organ slowly deteriorates despite all efforts at immunosuppression. (jrank.org)
Recipients3
Different organs1
Chemoradiation1
  • Organ preservation appears oncologically safe for selected rectal cancer patients with a cCR or near cCR after neoadjuvant chemoradiation when applying strict selection criteria and frequent follow-up, including endoscopy and MRI. (snfge.org)
Donation after circulatory2
Organ Preservation Market, Size, Share, Outlook and Growth Opportunities 2019-2026
Organ Preservation Market, Size, Share, Outlook and Growth Opportunities 2019-2026 (datamintelligence.com)
Positive cultures of organ preservation fluid predict postoperative infections in solid organ transplantation recipients |...
Positive cultures of organ preservation fluid predict postoperative infections in solid organ transplantation recipients |... (transplantnow.com)
Impact of 24 h continuous hypothermic perfusion on heart preservation by assessment of oxidative stress<...
Impact of 24 h continuous hypothermic perfusion on heart preservation by assessment of oxidative stress<... (pennstate.pure.elsevier.com)
UC Health performs first liver transplant in US using mobile cold perfusion pump - Organ Donation and Transplantation Alliance
UC Health performs first liver transplant in US using mobile cold perfusion pump - Organ Donation and Transplantation Alliance (organdonationalliance.org)
Machine Perfusion of Donor Livers for Transplantation: A Proposal for Standardized Nomenclature and Reporting Guidelines.
Machine Perfusion of Donor Livers for Transplantation: A Proposal for Standardized Nomenclature and Reporting Guidelines. (repository.cam.ac.uk)
Skipping Surgery in Rectal Cancer: Better or Worse?
Skipping Surgery in Rectal Cancer: Better or Worse? (medscape.com)
Organ Preservation: Overview, Pathophysiology of Organ Preservation, Preservation Solutions and Their Pharmacology
Organ Preservation: Overview, Pathophysiology of Organ Preservation, Preservation Solutions and Their Pharmacology (emedicine.medscape.com)
Colorectal Cancer News, Articles and Research
Colorectal Cancer News, Articles and Research (news-medical.net)
Research in the Department of Surgery, University of Otago, Christchurch, University of Otago, Christchurch, University of...
Research in the Department of Surgery, University of Otago, Christchurch, University of Otago, Christchurch, University of... (otago.ac.nz)
Medicine | Springer
Medicine | Springer (springer.com)
New machine-perfusion organ preservation system keeps livers healthier for transplant | EurekAlert! Science News
New machine-perfusion organ preservation system keeps livers healthier for transplant | EurekAlert! Science News (eurekalert.org)
Collection Details : Transplantation
Collection Details : Transplantation (journals.lww.com)
Risk factors for primary dysfunction after liver transplantation in the University of Wisconsin solution era - Research...
Risk factors for primary dysfunction after liver transplantation in the University of Wisconsin solution era - Research... (rug.nl)
University of Minnesota College of Science and Engineering | Newswise
University of Minnesota College of Science and Engineering | Newswise (newswise.com)
Global Life Sciences BPO Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019
Global Life Sciences BPO Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 (prweb.com)
WP01 - Normothermic Liver Preservation - Full Text View - ClinicalTrials.gov
WP01 - Normothermic Liver Preservation - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
Management of the N3 Neck: Background, History of the Procedure, Problem
Management of the N3 Neck: Background, History of the Procedure, Problem (emedicine.medscape.com)
Organ Preservation Solutions - Global Market Trajectory & Analytics
Organ Preservation Solutions - Global Market Trajectory & Analytics (researchandmarkets.com)
Jyoti Basu's brain removed for preservation - Thaindian News
Jyoti Basu's brain removed for preservation - Thaindian News (thaindian.com)
Tumor Treatment | SpringerLink
Tumor Treatment | SpringerLink (link.springer.com)
Management of Severe Traumatic Brain Injury | SpringerLink
Management of Severe Traumatic Brain Injury | SpringerLink (link.springer.com)
Associate Faculty
Associate Faculty (jhsph.edu)
CMS Seoul May 2017 McCauley v5 by Raymond McCauley on Prezi
CMS Seoul May 2017 McCauley v5 by Raymond McCauley on Prezi (prezi.com)
The Origin of Species by Means of Natural Selection: Or the Preservation of ... - Charles Darwin - Google Books
The Origin of Species by Means of Natural Selection: Or the Preservation of ... - Charles Darwin - Google Books (books.google.co.uk)
Effects of cyclosporine A pretreatment of deceased organ donors on kidney graft function (Cis-A-rein): study protocol for a...
Effects of cyclosporine A pretreatment of deceased organ donors on kidney graft function (Cis-A-rein): study protocol for a... (link.springer.com)
Browse School of Medicine | Stanford Medicine Profiles
Browse School of Medicine | Stanford Medicine Profiles (med.stanford.edu)
Geoscience Research Institute | Preservation of Dinosaur Soft Tissue: An Update
Geoscience Research Institute | Preservation of Dinosaur Soft Tissue: An Update (grisda.org)
New 'Supercooling' Technique Helps Preserve Organs | Live Science
New 'Supercooling' Technique Helps Preserve Organs | Live Science (livescience.com)
Transplant International : Proceedings of the European Society for Organ Transplantation, Maastricht, October 7-10, 1991 -...
Transplant International : Proceedings of the European Society for Organ Transplantation, Maastricht, October 7-10, 1991 -... (booktopia.com.au)
Hypopharyngeal Cancer: Overview, Clinical Presentation, Etiology and Risk Factors
Hypopharyngeal Cancer: Overview, Clinical Presentation, Etiology and Risk Factors (emedicine.medscape.com)
Engineering stars win Academy Silver Medals - Royal Academy of Engineering
Engineering stars win Academy Silver Medals - Royal Academy of Engineering (raeng.org.uk)
Organ-on-a-chip model offers insights into premature aging and vascular disease
Organ-on-a-chip model offers insights into premature aging and vascular disease (phys.org)
Open Questions in Aging and Cryobiology | by Good Ancestry | Medium
Open Questions in Aging and Cryobiology | by Good Ancestry | Medium (medium.com)