Organ Preservation
Organ Preservation Solutions
Raffinose
Laryngeal Neoplasms
Allopurinol
Carcinoma, Squamous Cell
Brain Death
Head and Neck Neoplasms
Combined Modality Therapy
Cryopreservation
Fluorouracil
Cisplatin
Mannitol
Fertility Preservation
Reperfusion Injury
Liver Transplantation
Radiotherapy, Adjuvant
Graft Survival
Tissue Donors
Hydroxyurea
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols
Adenosine
Glutathione
Salvage Therapy
Neoplasm Staging
Graft Rejection
Survival Analysis
Tissue and Organ Procurement
Organ Transplantation
Liver
Survival Rate
Retrospective Studies
Follow-Up Studies
Disease-Free Survival
Semen Preservation
Multiple Organ Failure
Organ Specificity
Organ of Corti
Cold Ischemia
Freeze Drying
Beta-glucan reflects liver injury after preservation and transplantation in dogs. (1/524)
Graft failure and extrahepatic organ complications, which frequently develop after transplantation, may be related to inflammatory mediators stimulated by endotoxin (ET). The role of endotoxemia after liver transplantation is controversial and may depend upon differences in the ET assay method used in the various contradicting studies. While the standard Limulus amebocyte lysate (LAL) is reactive for ET and beta-glucan, a novel turbidimetric assay method enables separate determinations of ET and beta-glucan. Beagle dogs undergoing orthotopic liver transplantation were divided into two groups. In Group I (n = 6) the grafts were transplanted immediately and in Group II (n = 6) grafts were preserved for 48 h in University of Wisconsin (UW) solution. Animals received cyclosporine immunosuppression and were followed for 14 days. Daily measurements of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were performed. Samples for ET and beta-glucan measurement were collected serially and processed using the turbidimetric assay method. While no graft failure was seen in Group I, three of six Group II animals died from graft failure within 1 day after transplantation. Preservation and reperfusion injury was much more severe in the Group II grafts than in Group I grafts. While endotoxemia could not be detected, postoperative beta-glucan levels (undetectable pretransplant) were seen in both groups. Beta-glucan levels were much higher in Group II grafts than in Group I grafts, and correlated with the severity of liver damage. In conclusion, this study shows that beta-glucan, instead of ET, appears during the early posttransplant period. We believe that posttransplant elevation of beta-glucan is related to liver damage, especially endothelial damage by preservation and reperfusion. (+info)Tissue donation after death in the accident and emergency department: an opportunity wasted? (2/524)
OBJECTIVE: To investigate whether the accident and emergency department (A&E) is a potential source of tissues for donation, from non-heart beating donors (NHBDs). METHODS: A telephone survey of 30 A&E departments was conducted to determine current tissue harvesting practices from NHBDs. The potential number of tissue donors in our own medium sized district general hospital A&E department was estimated. Senior nursing staff were asked to complete a questionnaire to establish their knowledge, attitudes, and experience of tissue harvesting from NHBDs. RESULTS: Only seven of the 30 A&E departments surveyed (23%) had an active involvement in requesting tissue donation after a sudden death. Several others had limited experience. The level of involvement was unrelated to department size. In our own A&E department, there were 110 deaths in 1995. Tissue donation had occurred on just three occasions. However, departmental staff attitudes towards reducing this shortfall were positive. CONCLUSIONS: The A&E department is a resource of tissues for donation, which is currently under used. (+info)Intravenous glycine improves survival in rat liver transplantation. (3/524)
In situ manipulation by touching, retracting, and moving liver lobes gently during harvest dramatically reduces survival after transplantation (P. Schemmer, R. Schoonhoven, J. A. Swenberg, H. Bunzendahl, and R. G. Thurman. Transplantation 65: 1015-1020, 1998). The development of harvest-dependent graft injury upon reperfusion can be prevented with GdCl3, a rare earth metal and Kupffer cell toxicant, but it cannot be used in clinical liver transplantation because of its potential toxicity. Thus the effect of glycine, which prevents activation of Kupffer cells, was assessed here. Minimal dissection of the liver for 12 min plus 13 min without manipulation had no effect on survival (100%). However, gentle manipulation decreased survival to 46% in the control group. Furthermore, serum transaminases and liver necrosis were elevated 4- to 12-fold 8 h after transplantation. After organ harvest, the rate of entry and exit of fluorescein dextran, a dye confined to the vascular space, was decreased about twofold, indicating disturbances in the hepatic microcirculation. Pimonidazole binding, which detects hypoxia, increased about twofold after organ manipulation, and Kupffer cells isolated from manipulated livers produced threefold more tumor necrosis factor-alpha after lipopolysaccharide than controls. Glycine given intravenously to the donor increased the serum glycine concentration about sevenfold and largely prevented the effect of gentle organ manipulation on all parameters studied. These data indicate for the first time that pretreatment of donors with intravenous glycine minimizes reperfusion injury due to organ manipulation during harvest and after liver transplantation. (+info)Organ transplantation--then and now. (4/524)
The last 25 years have seen amazing progress in transplantation--from the development of techniques for immunosuppression to methods for organ removal and preservation. Our distinguished authors focus on these developments and discuss how the momentum seen during the last quarter century can be accelerated. (+info)A study on continuous low-flow perfusion with low-potassium dextran for donor isolated lung preservation. (5/524)
OBJECTIVE: To test the validity of continuous low-flow perfusion with low-potassium dextran (LPD) to preserve rabbit lung. METHODS: Isolated rabbit lungs were preserved for eight hours either in Ringer's solution by simple storage (Group I) or in continuous low-flow perfusion with LPD (Group II). After preservation, lung functions were assessed to compare these two methods. RESULTS: The water gain in Group I was higher than that in Group II. During reperfusion, the functional test values for the immersed lungs were lower than those for the perfused lungs. The lipid peroxidation product (MDA) was significantly decreased in perfused lungs during reperfusion. CONCLUSIONS: Low-flow perfusion with LPD is better than immersion for the lung preservation. (+info)The effects of mannitol, albumin, and cardioplegia enhancers on 24-h rat heart preservation. (6/524)
During 24 h in vitro heart preservation and reperfusion, tissue damage occurs that seriously reduces cardiac function. Prevention of free radical production during preservation and reperfusion of ischemic tissue using free radical scavengers is of primary importance in maintaining optimal heart function in long-term preservation protocols. We examined whether mannitol (68 mM) and albumin (1.4 microM) in combination with other cardioplegia enhancers decreased free radical formation and edema and increased cardiac function during 24-h cold (5 degrees C) heart preservation and warm (37 degrees C) reperfusion in the Langendorff-isolated rat heart. The performance of mannitol-treated hearts was significantly decreased compared with that of hearts without mannitol treatment after 24 h of preservation with regard to recovery of diastolic pressure, contractility (+dP/dt), relaxation (-dP/dt), myocardial creatine kinase release, coronary flow, and lipid peroxidation. Albumin-treated hearts demonstrated higher cardiac function (contractility and coronary flow especially) than hearts not treated with albumin or hearts treated with mannitol, and this appears to be due to the positive effects of increased cellular metabolism and the enhancement of membrane stability. (+info)Endothelium-dependent relaxation of canine pulmonary artery endothelium after prolonged preservation. (7/524)
OBJECTIVE: Experiments were designed to investigate the effect of Euro-Collins (EC) solution and University of Wisconsin (UW) solution on function of pulmonary arterial endothelium. METHODS: Third order canine pulmonary artery segments were preserved in cold (4 degrees C) UW (group 1, n = 8) or EC (group 2, n = 9) solutions for 16 hours. The preserved (group 1 and 2) and control (group 3, n = 7) pulmonary arterial segments with and without endothelium were studied in vitro in organ chambers to measure isometric tension. RESULTS: The endothelium-dependent relaxation to acetylcholine and adenosine diphosphate of group 1 and 3 were significantly better than those of group 2. CONCLUSIONS: We concluded that endothelium-dependent relaxation of canine pulmonary arterial endothelium to receptor-dependent acetylcholine and adenosine diphosphate were impaired after preservation with Euro-Collins solution. However, endothelium-dependent relaxation of pulmonary segments were well maintained after preservation with University of Wisconsin solution. (+info)Controlling transplant vasculopathy in cryopreserved vein grafts with polyethylene glycol and glutathione during transport. (8/524)
BACKGROUND: the biological characteristics of cryopreserved allografts are poorly understood, although many factors are known to influence their outcome. This study examines the development of transplant vasculopathy in both fresh and cryopreserved vein allografts and specifically assesses the efficacy of a transport solution containing 10% polyethylene glycol and 10 microM glutathione (PEG/GSH). METHODS: jugular veins were harvested from control donor rabbits and transplanted as interposition carotid bypass grafts in 30 New Zealand White (NZW) rabbits. Ten received the fresh jugular veins (fresh). Ten animals received jugular veins which had been harvested, transported in a physiological solution, cryopreserved and stored in a standard fashion (cryopreserved). Ten animals received jugular veins which had been harvested, transported in the same solution with the addition of PEG/GSH, cryopreserved and stored in a standard fashion (PEG/GSH). Cryopreserved jugular veins were stored for 6 weeks before transplantation. All animals were sacrificed 28 days postoperatively. Vein grafts were perfusion-fixed and wall dimensions were determined by planimetry. RESULTS: all transplanted grafts were patent at harvest. The control cryopreserved vein grafts showed a 54% increase in mean intimal thickness (63+/-10 micron vs. 41+/-3 micron p<0.05) but no change in mean medial thickness (125+/-9 micron vs. 119+/-13 micron; p = N.S. ) compared to the fresh allograft. Transport of the grafts in PEG/GSH solution resulted in the abolition of the increase in intimal thickness (41+/-4 micron; p <0.01) associated with cryopreservation without a change in medial thickness (140+/-15 micron; p = N.S.) compared to the cryopreserved allograft. CONCLUSION: cryopreserved vein grafts develop significant intimal hyperplasia compared to freshly transplanted grafts. The use of PEG/GSH in the transport solution significantly reduces this transplant graft intimal hyperplasia to that which develops in fresh grafts and may lead to improvements in the clinical use of cryopreserved veins. (+info)Organ preservation is a medical technique used to maintain the viability and functionality of an organ outside the body for a certain period, typically for transplantation purposes. This process involves cooling the organ to slow down its metabolic activity and prevent tissue damage, while using specialized solutions that help preserve the organ's structure and function. Commonly preserved organs include hearts, livers, kidneys, lungs, and pancreases. The goal of organ preservation is to ensure that the transplanted organ remains in optimal condition until it can be successfully implanted into a recipient.
Organ preservation solutions are specialized fluids used to maintain the viability and functionality of organs ex vivo (outside the body) during the process of transplantation. These solutions are designed to provide optimal conditions for the organ by preventing tissue damage, reducing metabolic activity, and minimizing ischemic injuries that may occur during the time between organ removal from the donor and implantation into the recipient.
The composition of organ preservation solutions typically includes various ingredients such as:
1. Cryoprotectants: These help prevent ice crystal formation and damage to cell membranes during freezing and thawing processes, especially for organs like the heart and lungs that require deep hypothermia for preservation.
2. Buffers: They maintain physiological pH levels and counteract acidosis caused by anaerobic metabolism in the absence of oxygen supply.
3. Colloids: These substances, such as hydroxyethyl starch or dextran, help preserve oncotic pressure and prevent cellular edema.
4. Electrolytes: Balanced concentrations of ions like sodium, potassium, calcium, magnesium, chloride, and bicarbonate are essential for maintaining physiological osmolarity and membrane potentials.
5. Energy substrates: Glucose, lactate, or other energy-rich compounds can serve as fuel sources to support the metabolic needs of the organ during preservation.
6. Antioxidants: These agents protect against oxidative stress and lipid peroxidation induced by ischemia-reperfusion injuries.
7. Anti-inflammatory agents and immunosuppressants: Some solutions may contain substances that mitigate the inflammatory response and reduce immune activation in the transplanted organ.
Examples of commonly used organ preservation solutions include University of Wisconsin (UW) solution, Histidine-Tryptophan-Ketoglutarate (HTK) solution, Custodiol HTK solution, and Euro-Collins solution. The choice of preservation solution depends on the specific organ being transplanted and the duration of preservation required.
A laryngectomy is a surgical procedure that involves the removal of the larynx, also known as the voice box. This is typically performed in cases of advanced laryngeal cancer or other severe diseases of the larynx. After the surgery, the patient will have a permanent stoma (opening) in the neck to allow for breathing. The ability to speak after a total laryngectomy can be restored through various methods such as esophageal speech, tracheoesophageal puncture with a voice prosthesis, or electronic devices.
Raffinose is a complex carbohydrate, specifically an oligosaccharide, that is composed of three sugars: galactose, fructose, and glucose. It is a non-reducing sugar, which means it does not undergo oxidation reactions like reducing sugars do.
Raffinose is found in various plants, including beans, cabbage, brussels sprouts, broccoli, and whole grains. It is a member of the class of carbohydrates known as alpha-galactosides.
In humans, raffinose cannot be digested because we lack the enzyme alpha-galactosidase, which is necessary to break down the bond between galactose and glucose in raffinose. As a result, it passes through the small intestine intact and enters the large intestine, where it is fermented by gut bacteria. This fermentation process can lead to the production of gases such as methane and hydrogen, which can cause digestive discomfort, bloating, and flatulence in some individuals.
It's worth noting that raffinose has been studied for its potential prebiotic properties, as it can promote the growth of beneficial gut bacteria. However, excessive consumption may lead to digestive issues in sensitive individuals.
Laryngeal neoplasms refer to abnormal growths or tumors in the larynx, also known as the voice box. These growths can be benign (non-cancerous) or malignant (cancerous). Laryngeal neoplasms can affect any part of the larynx, including the vocal cords, epiglottis, and the area around the vocal cords called the ventricle.
Benign laryngeal neoplasms may include papillomas, hemangiomas, or polyps. Malignant laryngeal neoplasms are typically squamous cell carcinomas, which account for more than 95% of all malignant laryngeal tumors. Other types of malignant laryngeal neoplasms include adenocarcinoma, sarcoma, and lymphoma.
Risk factors for developing laryngeal neoplasms include smoking, alcohol consumption, exposure to industrial chemicals, and a history of acid reflux. Symptoms may include hoarseness, difficulty swallowing, sore throat, ear pain, or a lump in the neck. Treatment options depend on the type, size, location, and stage of the neoplasm but may include surgery, radiation therapy, chemotherapy, or a combination of these treatments.
Hypopharyngeal neoplasms refer to abnormal growths or tumors in the hypopharynx, which is the lower part of the pharynx or throat. These growths can be benign (non-cancerous) or malignant (cancerous). Malignant hypopharyngeal neoplasms are often squamous cell carcinomas and are aggressive with a poor prognosis due to their location and tendency to spread early. They can cause symptoms such as difficulty swallowing, pain when swallowing, sore throat, ear pain, and neck masses. Risk factors for hypopharyngeal cancer include smoking, heavy alcohol consumption, and poor nutrition.
Allopurinol is a medication used to treat chronic gout and certain types of kidney stones. It works by reducing the production of uric acid in the body, which is the substance that can cause these conditions when it builds up in high levels. Allopurinol is a xanthine oxidase inhibitor, meaning it blocks an enzyme called xanthine oxidase from converting purines into uric acid. By doing this, allopurinol helps to lower the levels of uric acid in the body and prevent the formation of new kidney stones or gout attacks.
It is important to note that allopurinol can have side effects, including rash, stomach upset, and liver or kidney problems. It may also interact with other medications, so it is essential to inform your healthcare provider of any other drugs you are taking before starting allopurinol. Your healthcare provider will determine the appropriate dosage and monitoring schedule based on your individual needs and medical history.
A pharyngectomy is a surgical procedure that involves the removal of all or part of the pharynx, which is the muscular tube that extends from the back of the nasal cavity and mouth to the esophagus. This procedure is typically performed to treat cancers of the head and neck, such as throat cancer, that have invaded the tissues of the pharynx.
During a pharyngectomy, an incision is made in the neck or chest, depending on the location of the tumor. The surgeon then carefully dissects the pharynx away from surrounding structures, such as the esophagus, carotid artery, and spinal cord. Depending on the extent of the cancer, nearby lymph nodes may also be removed.
After the pharynx has been removed, the surgeon will reconstruct the area using tissue from another part of the body, such as the forearm or leg. This reconstruction is necessary to restore normal functions such as swallowing and speaking.
Pharyngectomy is a complex surgical procedure that requires extensive training and expertise. It carries significant risks, including bleeding, infection, and damage to surrounding structures. However, for some patients with advanced throat cancer, it may be the best option for achieving long-term survival.
Squamous cell carcinoma is a type of skin cancer that begins in the squamous cells, which are flat, thin cells that form the outer layer of the skin (epidermis). It commonly occurs on sun-exposed areas such as the face, ears, lips, and backs of the hands. Squamous cell carcinoma can also develop in other areas of the body including the mouth, lungs, and cervix.
This type of cancer usually develops slowly and may appear as a rough or scaly patch of skin, a red, firm nodule, or a sore or ulcer that doesn't heal. While squamous cell carcinoma is not as aggressive as some other types of cancer, it can metastasize (spread) to other parts of the body if left untreated, making early detection and treatment important.
Risk factors for developing squamous cell carcinoma include prolonged exposure to ultraviolet (UV) radiation from the sun or tanning beds, fair skin, a history of sunburns, a weakened immune system, and older age. Prevention measures include protecting your skin from the sun by wearing protective clothing, using a broad-spectrum sunscreen with an SPF of at least 30, avoiding tanning beds, and getting regular skin examinations.
Brain death is a legal and medical determination that an individual has died because their brain has irreversibly lost all functions necessary for life. It is characterized by the absence of brainstem reflexes, unresponsiveness to stimuli, and the inability to breathe without mechanical support. Brain death is different from a vegetative state or coma, where there may still be some brain activity.
The determination of brain death involves a series of tests and examinations to confirm the absence of brain function. These tests are typically performed by trained medical professionals and may include clinical assessments, imaging studies, and electroencephalograms (EEGs) to confirm the absence of electrical activity in the brain.
Brain death is an important concept in medicine because it allows for the organ donation process to proceed, potentially saving the lives of others. In many jurisdictions, brain death is legally equivalent to cardiopulmonary death, which means that once a person has been declared brain dead, they are considered deceased and their organs can be removed for transplantation.
Head and neck neoplasms refer to abnormal growths or tumors in the head and neck region, which can be benign (non-cancerous) or malignant (cancerous). These tumors can develop in various sites, including the oral cavity, nasopharynx, oropharynx, larynx, hypopharynx, paranasal sinuses, salivary glands, and thyroid gland.
Benign neoplasms are slow-growing and generally do not spread to other parts of the body. However, they can still cause problems if they grow large enough to press on surrounding tissues or structures. Malignant neoplasms, on the other hand, can invade nearby tissues and organs and may also metastasize (spread) to other parts of the body.
Head and neck neoplasms can have various symptoms depending on their location and size. Common symptoms include difficulty swallowing, speaking, or breathing; pain in the mouth, throat, or ears; persistent coughing or hoarseness; and swelling or lumps in the neck or face. Early detection and treatment of head and neck neoplasms are crucial for improving outcomes and reducing the risk of complications.
Combined modality therapy (CMT) is a medical treatment approach that utilizes more than one method or type of therapy simultaneously or in close succession, with the goal of enhancing the overall effectiveness of the treatment. In the context of cancer care, CMT often refers to the combination of two or more primary treatment modalities, such as surgery, radiation therapy, and systemic therapies (chemotherapy, immunotherapy, targeted therapy, etc.).
The rationale behind using combined modality therapy is that each treatment method can target cancer cells in different ways, potentially increasing the likelihood of eliminating all cancer cells and reducing the risk of recurrence. The specific combination and sequence of treatments will depend on various factors, including the type and stage of cancer, patient's overall health, and individual preferences.
For example, a common CMT approach for locally advanced rectal cancer may involve preoperative (neoadjuvant) chemoradiation therapy, followed by surgery to remove the tumor, and then postoperative (adjuvant) chemotherapy. This combined approach allows for the reduction of the tumor size before surgery, increases the likelihood of complete tumor removal, and targets any remaining microscopic cancer cells with systemic chemotherapy.
It is essential to consult with a multidisciplinary team of healthcare professionals to determine the most appropriate CMT plan for each individual patient, considering both the potential benefits and risks associated with each treatment method.
Biological preservation is the process of preventing decomposition or decay of biological materials, such as tissues, cells, organs, or organisms, in order to maintain their structural and functional integrity for further studies, research, education, or conservation purposes. This can be achieved through various methods, including fixation, freezing, drying, or the use of chemical preservatives. The goal is to maintain the samples in a stable state so that they can be examined, analyzed, or used in experiments at a later time.
Pancreas transplantation is a surgical procedure that involves implanting a healthy pancreas from a deceased donor into a recipient with diabetes. The primary goal of this procedure is to restore the recipient's insulin production and eliminate the need for insulin injections, thereby improving their quality of life and reducing the risk of long-term complications associated with diabetes.
There are three main types of pancreas transplantation:
1. Simultaneous pancreas-kidney (SPK) transplantation: This is the most common type of pancreas transplant, performed simultaneously with a kidney transplant in patients with diabetes and end-stage renal disease (ESRD). The new pancreas not only restores insulin production but also helps prevent further kidney damage.
2. Pancreas after kidney (PAK) transplantation: In this procedure, a patient receives a kidney transplant first, followed by a pancreas transplant at a later time. This is typically performed in patients who have already undergone a successful kidney transplant and wish to improve their diabetes management.
3. Pancreas transplantation alone (PTA): In rare cases, a pancreas transplant may be performed without a concurrent kidney transplant. This is usually considered for patients with brittle diabetes who experience severe hypoglycemic episodes despite optimal medical management and lifestyle modifications.
The success of pancreas transplantation has significantly improved over the years, thanks to advancements in surgical techniques, immunosuppressive medications, and post-transplant care. However, it is essential to weigh the benefits against the risks, such as potential complications related to surgery, infection, rejection, and long-term use of immunosuppressive drugs. Ultimately, the decision to undergo pancreas transplantation should be made in consultation with a multidisciplinary team of healthcare professionals, considering each patient's unique medical history and personal circumstances.
Cryopreservation is a medical procedure that involves the preservation of cells, tissues, or organs by cooling them to very low temperatures, typically below -150°C. This is usually achieved using liquid nitrogen. The low temperature slows down or stops biological activity, including chemical reactions and cellular metabolism, which helps to prevent damage and decay.
The cells, tissues, or organs that are being cryopreserved must be treated with a cryoprotectant solution before cooling to prevent the formation of ice crystals, which can cause significant damage. Once cooled, the samples are stored in specialized containers or tanks until they are needed for use.
Cryopreservation is commonly used in assisted reproductive technologies, such as the preservation of sperm, eggs, and embryos for fertility treatments. It is also used in research, including the storage of cell lines and stem cells, and in clinical settings, such as the preservation of skin grafts and corneas for transplantation.
Fluorouracil is a antineoplastic medication, which means it is used to treat cancer. It is a type of chemotherapy drug known as an antimetabolite. Fluorouracil works by interfering with the growth of cancer cells and ultimately killing them. It is often used to treat colon, esophageal, stomach, and breast cancers, as well as skin conditions such as actinic keratosis and superficial basal cell carcinoma. Fluorouracil may be given by injection or applied directly to the skin in the form of a cream.
It is important to note that fluorouracil can have serious side effects, including suppression of bone marrow function, mouth sores, stomach and intestinal ulcers, and nerve damage. It should only be used under the close supervision of a healthcare professional.
Cisplatin is a chemotherapeutic agent used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. It is an inorganic platinum compound that contains a central platinum atom surrounded by two chloride atoms and two ammonia molecules in a cis configuration.
Cisplatin works by forming crosslinks between DNA strands, which disrupts the structure of DNA and prevents cancer cells from replicating. This ultimately leads to cell death and slows down or stops the growth of tumors. However, cisplatin can also cause damage to normal cells, leading to side effects such as nausea, vomiting, hearing loss, and kidney damage. Therefore, it is essential to monitor patients closely during treatment and manage any adverse effects promptly.
Mannitol is a type of sugar alcohol (a sugar substitute) used primarily as a diuretic to reduce brain swelling caused by traumatic brain injury or other causes that induce increased pressure in the brain. It works by drawing water out of the body through the urine. It's also used before surgeries in the heart, lungs, and kidneys to prevent fluid buildup.
In addition, mannitol is used in medical laboratories as a medium for growing bacteria and other microorganisms, and in some types of chemical research. In the clinic, it is also used as an osmotic agent in eye drops to reduce the pressure inside the eye in conditions such as glaucoma.
It's important to note that mannitol should be used with caution in patients with heart or kidney disease, as well as those who are dehydrated, because it can lead to electrolyte imbalances and other complications.
Fertility preservation is a medical procedure or treatment that is aimed at protecting and preserving the reproductive function and potential of an individual, typically before undergoing medical treatments that can potentially compromise their fertility. This may involve the cryopreservation (freezing) and storage of gametes (sperm or eggs), embryos, or reproductive tissues, such as ovarian or testicular tissue, for future use.
Fertility preservation is often recommended for individuals who are facing medical treatments that can have a negative impact on their fertility, such as chemotherapy, radiation therapy, or surgical removal of reproductive organs. It may also be considered for individuals with conditions that can affect their fertility, such as certain genetic disorders or autoimmune diseases.
The goal of fertility preservation is to allow individuals to have biological children in the future, even if their fertility is compromised by medical treatments or conditions. The success of fertility preservation depends on several factors, including the age and health of the individual at the time of preservation, the type and duration of the medical treatment, and the quality of the preserved gametes or tissues.
Reperfusion injury is a complex pathophysiological process that occurs when blood flow is restored to previously ischemic tissues, leading to further tissue damage. This phenomenon can occur in various clinical settings such as myocardial infarction (heart attack), stroke, or peripheral artery disease after an intervention aimed at restoring perfusion.
The restoration of blood flow leads to the generation of reactive oxygen species (ROS) and inflammatory mediators, which can cause oxidative stress, cellular damage, and activation of the immune system. This results in a cascade of events that may lead to microvascular dysfunction, capillary leakage, and tissue edema, further exacerbating the injury.
Reperfusion injury is an important consideration in the management of ischemic events, as interventions aimed at restoring blood flow must be carefully balanced with potential harm from reperfusion injury. Strategies to mitigate reperfusion injury include ischemic preconditioning (exposing the tissue to short periods of ischemia before a prolonged ischemic event), ischemic postconditioning (applying brief periods of ischemia and reperfusion after restoring blood flow), remote ischemic preconditioning (ischemia applied to a distant organ or tissue to protect the target organ), and pharmacological interventions that scavenge ROS, reduce inflammation, or improve microvascular function.
Perfusion, in medical terms, refers to the process of circulating blood through the body's organs and tissues to deliver oxygen and nutrients and remove waste products. It is a measure of the delivery of adequate blood flow to specific areas or tissues in the body. Perfusion can be assessed using various methods, including imaging techniques like computed tomography (CT) scans, magnetic resonance imaging (MRI), and perfusion scintigraphy.
Perfusion is critical for maintaining proper organ function and overall health. When perfusion is impaired or inadequate, it can lead to tissue hypoxia, acidosis, and cell death, which can result in organ dysfunction or failure. Conditions that can affect perfusion include cardiovascular disease, shock, trauma, and certain surgical procedures.
Liver transplantation is a surgical procedure in which a diseased or failing liver is replaced with a healthy one from a deceased donor or, less commonly, a portion of a liver from a living donor. The goal of the procedure is to restore normal liver function and improve the patient's overall health and quality of life.
Liver transplantation may be recommended for individuals with end-stage liver disease, acute liver failure, certain genetic liver disorders, or liver cancers that cannot be treated effectively with other therapies. The procedure involves complex surgery to remove the diseased liver and implant the new one, followed by a period of recovery and close medical monitoring to ensure proper function and minimize the risk of complications.
The success of liver transplantation has improved significantly in recent years due to advances in surgical techniques, immunosuppressive medications, and post-transplant care. However, it remains a major operation with significant risks and challenges, including the need for lifelong immunosuppression to prevent rejection of the new liver, as well as potential complications such as infection, bleeding, and organ failure.
Adjuvant radiotherapy is a type of cancer treatment that uses radiation therapy as an adjunct to a primary surgical procedure. The goal of adjuvant radiotherapy is to eliminate any remaining microscopic cancer cells that may be present in the surrounding tissues after surgery, thereby reducing the risk of local recurrence and improving the chances of cure.
Radiotherapy involves the use of high-energy radiation to destroy cancer cells and shrink tumors. In adjuvant radiotherapy, the radiation is usually delivered to the tumor bed and regional lymph nodes in order to target any potential sites of residual disease. The timing and dosing of adjuvant radiotherapy may vary depending on the type and stage of cancer being treated, as well as other factors such as patient age and overall health status.
Adjuvant radiotherapy is commonly used in the treatment of various types of cancer, including breast, colorectal, lung, head and neck, and gynecologic cancers. Its use has been shown to improve survival rates and reduce the risk of recurrence in many cases, making it an important component of comprehensive cancer care.
Graft survival, in medical terms, refers to the success of a transplanted tissue or organ in continuing to function and integrate with the recipient's body over time. It is the opposite of graft rejection, which occurs when the recipient's immune system recognizes the transplanted tissue as foreign and attacks it, leading to its failure.
Graft survival depends on various factors, including the compatibility between the donor and recipient, the type and location of the graft, the use of immunosuppressive drugs to prevent rejection, and the overall health of the recipient. A successful graft survival implies that the transplanted tissue or organ has been accepted by the recipient's body and is functioning properly, providing the necessary physiological support for the recipient's survival and improved quality of life.
A tissue donor is an individual who has agreed to allow organs and tissues to be removed from their body after death for the purpose of transplantation to restore the health or save the life of another person. The tissues that can be donated include corneas, heart valves, skin, bone, tendons, ligaments, veins, and cartilage. These tissues can enhance the quality of life for many recipients and are often used in reconstructive surgeries. It is important to note that tissue donation does not interfere with an open casket funeral or other cultural or religious practices related to death and grieving.
Hydroxyurea is an antimetabolite drug that is primarily used in the treatment of myeloproliferative disorders such as chronic myelogenous leukemia (CML), essential thrombocythemia, and polycythemia vera. It works by interfering with the synthesis of DNA, which inhibits the growth of cancer cells.
In addition to its use in cancer therapy, hydroxyurea is also used off-label for the management of sickle cell disease. In this context, it helps to reduce the frequency and severity of painful vaso-occlusive crises by increasing the production of fetal hemoglobin (HbF), which decreases the formation of sickled red blood cells.
The medical definition of hydroxyurea is:
A hydantoin derivative and antimetabolite that inhibits ribonucleoside diphosphate reductase, thereby interfering with DNA synthesis. It has been used as an antineoplastic agent, particularly in the treatment of myeloproliferative disorders, and more recently for the management of sickle cell disease to reduce the frequency and severity of painful vaso-occlusive crises by increasing fetal hemoglobin production.
Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.
Antineoplastic combined chemotherapy protocols refer to a treatment plan for cancer that involves the use of more than one antineoplastic (chemotherapy) drug given in a specific sequence and schedule. The combination of drugs is used because they may work better together to destroy cancer cells compared to using a single agent alone. This approach can also help to reduce the likelihood of cancer cells becoming resistant to the treatment.
The choice of drugs, dose, duration, and frequency are determined by various factors such as the type and stage of cancer, patient's overall health, and potential side effects. Combination chemotherapy protocols can be used in various settings, including as a primary treatment, adjuvant therapy (given after surgery or radiation to kill any remaining cancer cells), neoadjuvant therapy (given before surgery or radiation to shrink the tumor), or palliative care (to alleviate symptoms and prolong survival).
It is important to note that while combined chemotherapy protocols can be effective in treating certain types of cancer, they can also cause significant side effects, including nausea, vomiting, hair loss, fatigue, and an increased risk of infection. Therefore, patients undergoing such treatment should be closely monitored and managed by a healthcare team experienced in administering chemotherapy.
Radiotherapy dosage refers to the total amount of radiation energy that is absorbed by tissues or organs, typically measured in units of Gray (Gy), during a course of radiotherapy treatment. It is the product of the dose rate (the amount of radiation delivered per unit time) and the duration of treatment. The prescribed dosage for cancer treatments can range from a few Gray to more than 70 Gy, depending on the type and location of the tumor, the patient's overall health, and other factors. The goal of radiotherapy is to deliver a sufficient dosage to destroy the cancer cells while minimizing damage to surrounding healthy tissues.
Adenosine is a purine nucleoside that is composed of a sugar (ribose) and the base adenine. It plays several important roles in the body, including serving as a precursor for the synthesis of other molecules such as ATP, NAD+, and RNA.
In the medical context, adenosine is perhaps best known for its use as a pharmaceutical agent to treat certain cardiac arrhythmias. When administered intravenously, it can help restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT) by slowing conduction through the atrioventricular node and interrupting the reentry circuit responsible for the arrhythmia.
Adenosine can also be used as a diagnostic tool to help differentiate between narrow-complex tachycardias of supraventricular origin and those that originate from below the ventricles (such as ventricular tachycardia). This is because adenosine will typically terminate PSVT but not affect the rhythm of VT.
It's worth noting that adenosine has a very short half-life, lasting only a few seconds in the bloodstream. This means that its effects are rapidly reversible and generally well-tolerated, although some patients may experience transient symptoms such as flushing, chest pain, or shortness of breath.
Heart transplantation is a surgical procedure where a diseased, damaged, or failing heart is removed and replaced with a healthy donor heart. This procedure is usually considered as a last resort for patients with end-stage heart failure or severe coronary artery disease who have not responded to other treatments. The donor heart typically comes from a brain-dead individual whose family has agreed to donate their loved one's organs for transplantation. Heart transplantation is a complex and highly specialized procedure that requires a multidisciplinary team of healthcare professionals, including cardiologists, cardiac surgeons, anesthesiologists, perfusionists, nurses, and other support staff. The success rates for heart transplantation have improved significantly over the past few decades, with many patients experiencing improved quality of life and increased survival rates. However, recipients of heart transplants require lifelong immunosuppressive therapy to prevent rejection of the donor heart, which can increase the risk of infections and other complications.
Glutathione is a tripeptide composed of three amino acids: cysteine, glutamic acid, and glycine. It is a vital antioxidant that plays an essential role in maintaining cellular health and function. Glutathione helps protect cells from oxidative stress by neutralizing free radicals, which are unstable molecules that can damage cells and contribute to aging and diseases such as cancer, heart disease, and dementia. It also supports the immune system, detoxifies harmful substances, and regulates various cellular processes, including DNA synthesis and repair.
Glutathione is found in every cell of the body, with particularly high concentrations in the liver, lungs, and eyes. The body can produce its own glutathione, but levels may decline with age, illness, or exposure to toxins. As such, maintaining optimal glutathione levels through diet, supplementation, or other means is essential for overall health and well-being.
Salvage therapy, in the context of medical oncology, refers to the use of treatments that are typically considered less desirable or more aggressive, often due to greater side effects or lower efficacy, when standard treatment options have failed. These therapies are used to attempt to salvage a response or delay disease progression in patients with refractory or relapsed cancers.
In other words, salvage therapy is a last-resort treatment approach for patients who have not responded to first-line or subsequent lines of therapy. It may involve the use of different drug combinations, higher doses of chemotherapy, immunotherapy, targeted therapy, or radiation therapy. The goal of salvage therapy is to extend survival, improve quality of life, or achieve disease stabilization in patients with limited treatment options.
Neoplasm staging is a systematic process used in medicine to describe the extent of spread of a cancer, including the size and location of the original (primary) tumor and whether it has metastasized (spread) to other parts of the body. The most widely accepted system for this purpose is the TNM classification system developed by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC).
In this system, T stands for tumor, and it describes the size and extent of the primary tumor. N stands for nodes, and it indicates whether the cancer has spread to nearby lymph nodes. M stands for metastasis, and it shows whether the cancer has spread to distant parts of the body.
Each letter is followed by a number that provides more details about the extent of the disease. For example, a T1N0M0 cancer means that the primary tumor is small and has not spread to nearby lymph nodes or distant sites. The higher the numbers, the more advanced the cancer.
Staging helps doctors determine the most appropriate treatment for each patient and estimate the patient's prognosis. It is an essential tool for communication among members of the healthcare team and for comparing outcomes of treatments in clinical trials.
Kidney transplantation is a surgical procedure where a healthy kidney from a deceased or living donor is implanted into a patient with end-stage renal disease (ESRD) or permanent kidney failure. The new kidney takes over the functions of filtering waste and excess fluids from the blood, producing urine, and maintaining the body's electrolyte balance.
The transplanted kidney is typically placed in the lower abdomen, with its blood vessels connected to the recipient's iliac artery and vein. The ureter of the new kidney is then attached to the recipient's bladder to ensure proper urine flow. Following the surgery, the patient will require lifelong immunosuppressive therapy to prevent rejection of the transplanted organ by their immune system.
Graft rejection is an immune response that occurs when transplanted tissue or organ (the graft) is recognized as foreign by the recipient's immune system, leading to the activation of immune cells to attack and destroy the graft. This results in the failure of the transplant and the need for additional medical intervention or another transplant. There are three types of graft rejection: hyperacute, acute, and chronic. Hyperacute rejection occurs immediately or soon after transplantation due to pre-existing antibodies against the graft. Acute rejection typically occurs within weeks to months post-transplant and is characterized by the infiltration of T-cells into the graft. Chronic rejection, which can occur months to years after transplantation, is a slow and progressive process characterized by fibrosis and tissue damage due to ongoing immune responses against the graft.
Survival analysis is a branch of statistics that deals with the analysis of time to event data. It is used to estimate the time it takes for a certain event of interest to occur, such as death, disease recurrence, or treatment failure. The event of interest is called the "failure" event, and survival analysis estimates the probability of not experiencing the failure event until a certain point in time, also known as the "survival" probability.
Survival analysis can provide important information about the effectiveness of treatments, the prognosis of patients, and the identification of risk factors associated with the event of interest. It can handle censored data, which is common in medical research where some participants may drop out or be lost to follow-up before the event of interest occurs.
Survival analysis typically involves estimating the survival function, which describes the probability of surviving beyond a certain time point, as well as hazard functions, which describe the instantaneous rate of failure at a given time point. Other important concepts in survival analysis include median survival times, restricted mean survival times, and various statistical tests to compare survival curves between groups.
Tissue and organ procurement is the process of obtaining viable tissues and organs from deceased or living donors for the purpose of transplantation, research, or education. This procedure is performed by trained medical professionals in a sterile environment, adhering to strict medical standards and ethical guidelines. The tissues and organs that can be procured include hearts, lungs, livers, kidneys, pancreases, intestines, corneas, skin, bones, tendons, and heart valves. The process involves a thorough medical evaluation of the donor, as well as consent from the donor or their next of kin. After procurement, the tissues and organs are preserved and transported to recipients in need.
Organ transplantation is a surgical procedure where an organ or tissue from one person (donor) is removed and placed into another person (recipient) whose organ or tissue is not functioning properly or has been damaged beyond repair. The goal of this complex procedure is to replace the non-functioning organ with a healthy one, thereby improving the recipient's quality of life and overall survival.
Organs that can be transplanted include the heart, lungs, liver, kidneys, pancreas, and intestines. Tissues such as corneas, skin, heart valves, and bones can also be transplanted. The donor may be deceased or living, depending on the type of organ and the medical circumstances.
Organ transplantation is a significant and life-changing event for both the recipient and their families. It requires careful evaluation, matching, and coordination between the donor and recipient, as well as rigorous post-transplant care to ensure the success of the procedure and minimize the risk of rejection.
The liver is a large, solid organ located in the upper right portion of the abdomen, beneath the diaphragm and above the stomach. It plays a vital role in several bodily functions, including:
1. Metabolism: The liver helps to metabolize carbohydrates, fats, and proteins from the food we eat into energy and nutrients that our bodies can use.
2. Detoxification: The liver detoxifies harmful substances in the body by breaking them down into less toxic forms or excreting them through bile.
3. Synthesis: The liver synthesizes important proteins, such as albumin and clotting factors, that are necessary for proper bodily function.
4. Storage: The liver stores glucose, vitamins, and minerals that can be released when the body needs them.
5. Bile production: The liver produces bile, a digestive juice that helps to break down fats in the small intestine.
6. Immune function: The liver plays a role in the immune system by filtering out bacteria and other harmful substances from the blood.
Overall, the liver is an essential organ that plays a critical role in maintaining overall health and well-being.
Medical survival rate is a statistical measure used to determine the percentage of patients who are still alive for a specific period of time after their diagnosis or treatment for a certain condition or disease. It is often expressed as a five-year survival rate, which refers to the proportion of people who are alive five years after their diagnosis. Survival rates can be affected by many factors, including the stage of the disease at diagnosis, the patient's age and overall health, the effectiveness of treatment, and other health conditions that the patient may have. It is important to note that survival rates are statistical estimates and do not necessarily predict an individual patient's prognosis.
Retrospective studies, also known as retrospective research or looking back studies, are a type of observational study that examines data from the past to draw conclusions about possible causal relationships between risk factors and outcomes. In these studies, researchers analyze existing records, medical charts, or previously collected data to test a hypothesis or answer a specific research question.
Retrospective studies can be useful for generating hypotheses and identifying trends, but they have limitations compared to prospective studies, which follow participants forward in time from exposure to outcome. Retrospective studies are subject to biases such as recall bias, selection bias, and information bias, which can affect the validity of the results. Therefore, retrospective studies should be interpreted with caution and used primarily to generate hypotheses for further testing in prospective studies.
Follow-up studies are a type of longitudinal research that involve repeated observations or measurements of the same variables over a period of time, in order to understand their long-term effects or outcomes. In medical context, follow-up studies are often used to evaluate the safety and efficacy of medical treatments, interventions, or procedures.
In a typical follow-up study, a group of individuals (called a cohort) who have received a particular treatment or intervention are identified and then followed over time through periodic assessments or data collection. The data collected may include information on clinical outcomes, adverse events, changes in symptoms or functional status, and other relevant measures.
The results of follow-up studies can provide important insights into the long-term benefits and risks of medical interventions, as well as help to identify factors that may influence treatment effectiveness or patient outcomes. However, it is important to note that follow-up studies can be subject to various biases and limitations, such as loss to follow-up, recall bias, and changes in clinical practice over time, which must be carefully considered when interpreting the results.
Disease-free survival (DFS) is a term used in medical research and clinical practice, particularly in the field of oncology. It refers to the length of time after primary treatment for a cancer during which no evidence of the disease can be found. This means that the patient shows no signs or symptoms of the cancer, and any imaging studies or other tests do not reveal any tumors or other indications of the disease.
DFS is often used as an important endpoint in clinical trials to evaluate the effectiveness of different treatments for cancer. By measuring the length of time until the cancer recurs or a new cancer develops, researchers can get a better sense of how well a particular treatment is working and whether it is improving patient outcomes.
It's important to note that DFS is not the same as overall survival (OS), which refers to the length of time from primary treatment until death from any cause. While DFS can provide valuable information about the effectiveness of cancer treatments, it does not necessarily reflect the impact of those treatments on patients' overall survival.
Semen preservation is the process of collecting, liquefying, testing, and storing semen samples for future use in assisted reproductive technologies (ART) such as artificial insemination (AI), in vitro fertilization (IVF), or intracytoplasmic sperm injection (ICSI). The semen sample is usually collected through masturbation, and then it is mixed with a cryoprotectant solution to prevent damage during the freezing and thawing process. After that, the sample is divided into straws or vials and frozen in liquid nitrogen tanks at temperatures below -196°C. Properly preserved semen can be stored for many years without significant loss of quality or fertility potential. Semen preservation is often recommended for men who are about to undergo medical treatments that may affect their sperm production or fertility, such as chemotherapy or radiation therapy, or for those who wish to postpone fatherhood for personal or medical reasons.
Food preservation, in the context of medical and nutritional sciences, refers to the process of treating, handling, and storing food items to reduce the risk of foodborne illness and to extend their shelf life. The goal is to prevent the growth of pathogenic microorganisms such as bacteria, yeasts, and mold, as well as to slow down the oxidation process that can lead to spoilage.
Common methods of food preservation include:
1. Refrigeration and freezing: These techniques slow down the growth of microorganisms and enzyme activity that cause food to spoil.
2. Canning: This involves sealing food in airtight containers, then heating them to destroy microorganisms and inactivate enzymes.
3. Dehydration: Removing water from food inhibits the growth of bacteria, yeasts, and molds.
4. Acidification: Adding acidic ingredients like lemon juice or vinegar can lower the pH of food, making it less hospitable to microorganisms.
5. Fermentation: This process involves converting sugars into alcohol or acids using bacteria or yeasts, which can preserve food and also enhance its flavor.
6. Irradiation: Exposing food to small doses of radiation can kill bacteria, parasites, and insects, extending the shelf life of certain foods.
7. Pasteurization: Heating food to a specific temperature for a set period of time can destroy harmful bacteria while preserving the nutritional value and taste.
Proper food preservation is crucial in preventing foodborne illnesses and ensuring the safety and quality of the food supply.
Multiple Organ Failure (MOF) is a severe condition characterized by the dysfunction or failure of more than one organ system in the body. It often occurs as a result of serious illness, trauma, or infection, such as sepsis. The organs that commonly fail include the lungs, kidneys, liver, and heart. This condition can lead to significant morbidity and mortality if not promptly diagnosed and treated.
The definition of MOF has evolved over time, but a widely accepted one is the "Sequential Organ Failure Assessment" (SOFA) score, which evaluates six organ systems: respiratory, coagulation, liver, cardiovascular, renal, and neurologic. A SOFA score of 10 or more indicates MOF, and a higher score is associated with worse outcomes.
MOF can be classified as primary or secondary. Primary MOF occurs when the initial insult directly causes organ dysfunction, such as in severe trauma or septic shock. Secondary MOF occurs when the initial injury or illness has been controlled, but organ dysfunction develops later due to ongoing inflammation and other factors.
Early recognition and aggressive management of MOF are crucial for improving outcomes. Treatment typically involves supportive care, such as mechanical ventilation, dialysis, and medication to support cardiovascular function. In some cases, surgery or other interventions may be necessary to address the underlying cause of organ dysfunction.
Organ size refers to the volume or physical measurement of an organ in the body of an individual. It can be described in terms of length, width, and height or by using specialized techniques such as imaging studies (like CT scans or MRIs) to determine the volume. The size of an organ can vary depending on factors such as age, sex, body size, and overall health status. Changes in organ size may indicate various medical conditions, including growths, inflammation, or atrophy.
Organ specificity, in the context of immunology and toxicology, refers to the phenomenon where a substance (such as a drug or toxin) or an immune response primarily affects certain organs or tissues in the body. This can occur due to various reasons such as:
1. The presence of specific targets (like antigens in the case of an immune response or receptors in the case of drugs) that are more abundant in these organs.
2. The unique properties of certain cells or tissues that make them more susceptible to damage.
3. The way a substance is metabolized or cleared from the body, which can concentrate it in specific organs.
For example, in autoimmune diseases, organ specificity describes immune responses that are directed against antigens found only in certain organs, such as the thyroid gland in Hashimoto's disease. Similarly, some toxins or drugs may have a particular affinity for liver cells, leading to liver damage or specific drug interactions.
The Organ of Corti is the sensory organ of hearing within the cochlea of the inner ear. It is a structure in the inner spiral sulcus of the cochlear duct and is responsible for converting sound vibrations into electrical signals that are sent to the brain via the auditory nerve.
The Organ of Corti consists of hair cells, which are sensory receptors with hair-like projections called stereocilia on their apical surfaces. These stereocilia are embedded in a gelatinous matrix and are arranged in rows of different heights. When sound vibrations cause the fluid in the cochlea to move, the stereocilia bend, which opens ion channels and triggers nerve impulses that are sent to the brain.
Damage or loss of hair cells in the Organ of Corti can result in hearing loss, making it a critical structure for maintaining normal auditory function.
Cold ischemia is a medical term that refers to the loss of blood flow and subsequent lack of oxygen delivery to an organ or tissue, which is then cooled and stored in a solution at temperatures between 0-4°C (32-39°F) for the purpose of transplantation. The term "cold" indicates the temperature range, while "ischemia" refers to the lack of blood flow and oxygen delivery to the tissue.
During cold ischemia, the metabolic activity of the organ or tissue slows down significantly, which helps to reduce the rate of cellular damage that would otherwise occur due to the absence of oxygen and nutrients. However, even with cold storage, there is still some degree of injury to the organ or tissue, and this can affect its function after transplantation.
The duration of cold ischemia time is an important factor in determining the success of a transplant procedure. Prolonged cold ischemia times are associated with increased risk of poor organ function and rejection, as well as decreased graft survival rates. Therefore, it is essential to minimize the cold ischemia time as much as possible during organ transplantation to ensure optimal outcomes for the recipient.
Freeze-drying, also known as lyophilization, is a method of preservation that involves the removal of water from a frozen product by sublimation, which is the direct transition of a solid to a gas. This process allows for the preservation of the original shape and structure of the material while significantly extending its shelf life. In medical contexts, freeze-drying can be used for various purposes, including the long-term storage of pharmaceuticals, vaccines, and diagnostic samples. The process helps maintain the efficacy and integrity of these materials until they are ready to be reconstituted with water and used.
In the field of medicine, "time factors" refer to the duration of symptoms or time elapsed since the onset of a medical condition, which can have significant implications for diagnosis and treatment. Understanding time factors is crucial in determining the progression of a disease, evaluating the effectiveness of treatments, and making critical decisions regarding patient care.
For example, in stroke management, "time is brain," meaning that rapid intervention within a specific time frame (usually within 4.5 hours) is essential to administering tissue plasminogen activator (tPA), a clot-busting drug that can minimize brain damage and improve patient outcomes. Similarly, in trauma care, the "golden hour" concept emphasizes the importance of providing definitive care within the first 60 minutes after injury to increase survival rates and reduce morbidity.
Time factors also play a role in monitoring the progression of chronic conditions like diabetes or heart disease, where regular follow-ups and assessments help determine appropriate treatment adjustments and prevent complications. In infectious diseases, time factors are crucial for initiating antibiotic therapy and identifying potential outbreaks to control their spread.
Overall, "time factors" encompass the significance of recognizing and acting promptly in various medical scenarios to optimize patient outcomes and provide effective care.
Blood preservation refers to the process of keeping blood viable and functional outside of the body for transfusion purposes. This is typically achieved through the addition of various chemical additives, such as anticoagulants and nutrients, to a storage solution in which the blood is contained. The preserved blood is then refrigerated or frozen until it is needed for transfusion.
The goal of blood preservation is to maintain the structural integrity and functional capacity of the red blood cells, white blood cells, and platelets, as well as the coagulation factors, in order to ensure that the transfused blood is safe and effective. Different storage conditions and additives are used for the preservation of different components of blood, depending on their specific requirements.
It's important to note that while blood preservation extends the shelf life of donated blood, it does not last indefinitely. The length of time that blood can be stored depends on several factors, including the type of blood component and the storage conditions. Regular testing is performed to ensure that the preserved blood remains safe and effective for transfusion.
Viaspan
Index of oral health and dental articles
Hammond Organ Reed Factory
Severance Hall
Histidine-tryptophan-ketoglutarate
Wurlitzer theatre organs in the United Kingdom
Viability assay
St Paul's Cathedral, Dunedin
St Joseph's Cathedral, Dunedin
East Kilbride Civic Centre
List of churches in the Roman Catholic Diocese of Buffalo
Greg Fahy
Washington National Cathedral
Kidney paired donation
2014 in science
Holy Trinity Episcopal Church (Spring Lake, New Jersey)
Assisted migration
Assisted evolution
Artificial ovary
Organ transplantation
Cells Alive System
Cell damage
Jinggu Town
Ames Research Center
Thomas Starzl
Patriot Youth League of Sweden
Pineapple Fund
Digital preservation
Laryngectomy
2018 Queen's Birthday Honours (Australia)
Organ Preservation Ambulance - Crisis Magazine
Organ Preservation: Practice Essentials, Historical Background, Pathophysiology of Organ Preservation
Expanding Organ Preservation Surgery in Esophageal Cancer | Memorial Sloan Kettering Cancer Center
LifeLink of Puerto Rico Utilizes Paragonix Advanced Organ Preservation for Landmark Donor Organ Transport | Business Wire
Organ Preservation Market Around the world | 10 Top Companies - Forecast 2018-2023
Exceptional Preservation of Internal Organs in 50-Million-Year-Old Katydid Fossil - ScienceBlog.com
The Fair Organ Preservation Society Discussion Forum • Login
The Fair Organ Preservation Society Discussion Forum • Login
Japan Organ Preservation Market Size, Report 2023-2028
A new way to 'freeze' water could help transform organ preservation - Impact Lab
Europe Organ Preservation Market is developing at an exceptionally quick pace to reach USD 53 million by 2021.
New organ preservation system sees kidney flown thousands of miles as part of device debut - Medical Device Network
Organ Preservation | ORGAN STASIS
ORGAN PRESERVATION SYSTEMS - Z12019002 - Meditegic
Home | Advanced Organ Preservation Solutions | OPSL
Organ Preservation & Perfusion Products | Organ Transport Technology
Viaspan - Wikipedia
Global Organ Preservation Market - Size, Outlook, Trends and Forecasts
New solutions in organ preservation - Nuffield Department of Surgical Sciences
Life Sciences - Market Research and Industry Analysis Report
Optimizing outcomes in pancreas transplantation: Impact of organ preservation time - Fingerprint - Experts@Minnesota
University of Toledo professor to lead organ, tissue preservation … - Toledo Blade - MOHAN Foundation
Collection: Collection on the Kimball Organ Preservation Steering Committee | Hennepin County Library - ArchivesSpace
Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs | Nature Medicine
Organ Preservation Solution Market Overview: Market Size, Major Drivers And Trends - Latest Global Market Insights
JCM | Special Issue : JSOPB 2022-2023 Congress Special Issue - Update on Organ Preservation and Transplantation
Global Organ and Tissue Transplantation - Strategic Business Report 2015
Cardiology News, Articles and Research - Page 14
France Organ Preservation Market Development, Key Opportunities and Analysis of Key Players and forecast 2029 - bdnews55.com
Page 1 | Search Results | Transfusion Medicine and Hemotherapy | Karger Publishers
Transplants6
- Two decades of dedicated research at Europe's largest teaching hospital has resulted in the development of a greatly improved standard in organ preservation, aimed at extending the window for organ transplants to improve patient survival and quality of life. (opslgroup.com)
- Notably, statistics from the Organ Procurement and Transplantation Network (OPTN) highlight a 3.7% increase in organ transplants in 2022, with a significant portion dedicated to kidney transplants. (tbrc.info)
- A retrospective single-center analysis of 380 pancreas transplants (2000-2019) was performed to correlate current preservation solutions with transplant outcomes. (frontierspartnerships.org)
- As per, American Society of Nephrology states, an aged patient's body shows less graft rejection and that has led to increased preference for organ transplants by surgeons for them. (healthfirsto.com)
- Voluntary donations have become the only legal source of organs for transplant surgeries in China since January 2015, when China banned transplants of organs acquired from executed prisoners. (ecns.cn)
- A cluster of mucormycosis infections in patients with hematologic malignancies, stem cell transplants, and solid organ transplants. (cdc.gov)
20232
- IMARC Group provides an analysis of the key trends in each segment of the Japan organ preservation market report, along with forecasts at the country and regional levels from 2023-2028. (imarcgroup.com)
- The Organ Preservation Solution Global Market Report 2023 provides an overview of the organ preservation solution market for the time series: historic years (2010 - 2021) and ten years forecast (2023 - 2032). (tbrc.info)
Perfusion13
- The organ preservation process involves various techniques for storage and transportation purposes, such as static cold storage (SCS), normothermic machine perfusion (NMP), and hypothermic machine perfusion. (imarcgroup.com)
- The major players dominating the Organ Preservation market are Essential Pharmaceuticals (U.S.), Dr. Franz Kohler Chemie GmbH (Germany), Organ Recovery Systems (U.S.), Xvivo Perfusion AB (Sweden), and Waters Medical Systems LLC (U.S.), among others are the leaders in the Europe Organ Preservation market. (emailwire.com)
- Developed for abdominal organs - a next generation organ preservation solution for use during perfusion, retrieval, hypothermic storage and pre-implant preparation of kidney, liver and pancreas. (opslgroup.com)
- Organ procurement organizations and transplant centers around the world rely on Bridge to Life to provide Belzer UW® preservation and perfusion solutions with the highest in customer service. (bridgetolife.eu)
- Normothermic machine perfusion is a new paradigm for organ preservation profiting the market growth. (envisioninteligence.com)
- In this setting therefore, IGL-1 solution appears promising for perfusion and organ preservation in clinical pancreas transplantation, compared to other commonly used solutions. (frontierspartnerships.org)
- University of Wisconsin (UW) solution has been considered for organ perfusion in abdominal organ transplantation since the late 80s ( 8 ). (frontierspartnerships.org)
- The main purpose of the project was to develop a system that offers oxygenated machine perfusion at all different timepoints in the organ donation pathway: during preconditioning, preservation and reconditioning. (adesignaward.com)
- We empower transplant teams to save more lives XVIVO Perfusion is a medical technology company with headquarter in Gothenburg, Sweden, a production site in Lund, Sweden and offices in Denver, USA and Groningen, The Netherlands called Organ Assist. (adesignaward.com)
- We are focused on developing optimized solutions for organ, tissue and cell preservation and perfusion in connection with transplantation. (adesignaward.com)
- In terms of preservation technique, the global organ preservation solutions market has been divided into Hypothermic Perfusion Preservation, Static Cold Storage, and Others. (healthfirsto.com)
- The static cold storage segment is a standard solution utilize for organ preservation, and hypothermic perfusion preservation is expected to grow at highest CAGR during forecast period. (healthfirsto.com)
- Few attributable factors include the efficiency of hypothermic perfusion technique in continuous supply solution to the organ and hence prevents any tissue injury. (healthfirsto.com)
Liver11
- This article discusses the pathophysiology and techniques of organ preservation and describes various preservation solutions currently used for kidney , liver , pancreas , small-bowel , lung , and heart transplantation . (medscape.com)
- CAMBRIDGE, Mass.--( BUSINESS WIRE )--Paragonix Technologies, Inc. achieves a historic milestone in Puerto Rico with the first-ever utilization of its advanced liver preservation technology, the LIVERguard™ Donor Liver Preservation System , which preserved, monitored, and tracked a donor liver throughout its extended trip to a transplant center in Florida. (businesswire.com)
- First of its kind, the Paragonix LIVERguard system is an FDA-cleared device designed to optimize the preservation and transportation of a donor liver. (businesswire.com)
- We also want to translate] our approach to the preservation of exotic cell types and organs, such as the liver, since our center already has a very active cell and organ preservation research thrust. (impactlab.com)
- A new method for transporting, monitoring and protecting donated organs has helped facilitate a successful transplant after a liver travelled 1,200 miles from Puerto Rico to Florida. (medicaldevice-network.com)
- Massuchusetts, US-based Paragonix, has debuted its newest organ preservation system in the territory as they work alongside non-profits to ensure an urgently needed liver made it to its destination undamaged. (medicaldevice-network.com)
- Paragonix Technologies Inc.'s launch of the LIVERguard Donor Liver Preservation System in October 2021 stands as a testament to this trend, offering advanced settings for hypothermic liver preservation with real-time digital monitoring. (tbrc.info)
- The global and regional markets (except the US) for 'Organ and Tissue Transplantation' in this report are analyzed by the following Product Segments - Organ Tranplantation (Heart, Kidneys, Liver, Pancreas, and Lungs). (prnewswire.com)
- Rise in incidences of organ failure in kidney, liver and heart patients across the globe is augmenting the demand for organ transplant procedures. (healthfirsto.com)
- The attributable factors are growing organ transplantation in which solutions are utilized to preserve various organs such as kidney, lungs, liver and pancreas. (healthfirsto.com)
- Liver hepatocytic vacuolization, hyalinization, Councilman bodies, preservation of central area with mononuclear proliferation of hepatic sinusoids (18). (cdc.gov)
Tissues5
- These procedures prevent harmful metabolites from breaking down healthy tissues and maintain the temperature and oxygen levels of the organ, thereby increasing the survival rate of the receiver. (imarcgroup.com)
- Freezing can be a great way of preserving assorted foodstuffs or biological tissues and organs, but it's not without its risks. (impactlab.com)
- Plastination is a method of preserving organs and tissues by replacing fluids with plastic. (mohanfoundation.org)
- This medical procedure involves the extraction and transfer of organs or tissues from a donor to a recipient, showcasing the critical role preservation solutions play in reducing organ damage during transportation and storage. (tbrc.info)
- Transplantation of organs, tissues, etc. (assembly.ab.ca)
Tissue5
- LifeLink of Puerto Rico helps to facilitate the recovery of organs for transplantation within all hospitals in its donation service area, along with providing public education about the facts of donation and how individuals can save lives by joining the organ, tissue and eye donor registry while obtaining a driver license or online at www.DonateLifePuertoRico.org . (businesswire.com)
- The exceptional preservation of internal organs in the fossil, including thoracic muscles, undifferentiated tissue called the "fat body," and testis-related structures, has amazed scientists. (scienceblog.com)
- The Organ Preservation Alliance (OPA) is dedicated to accelerating organ preservation and transplant medicine, to better preserve donated organs, and create new organs from advances in tissue engineering. (organstasis.org)
- http://www.researchandmarkets.com/research/f7thqr/organ_and_tissue ) has announced the addition of the "Organ and Tissue Transplantation - Global Strategic Business Report" report to their offering. (prnewswire.com)
- This report analyzes the worldwide markets for Organ and Tissue Transplantation in Number of Procedures. (prnewswire.com)
Maintain the organs2
- Organ preservation is used to maintain the organs' quality prior to transplantation since the organs are susceptible to the air and can be broken if removed from the body. (emailwire.com)
- This has further led to rise in the demand for organ preservation solutions that help maintain the organs' viability from the time of donation to transplantation. (healthfirsto.com)
Biological2
Shortage3
- [ 8 ] Shortage of organs for transplantations prolongs patients' waiting time and increases the mortality and morbidity rates during the waiting time. (medscape.com)
- Dr. Shen Ren's Single-Mode Electromagnetic Resonance (SMER) system aims to fight the global shortage of organs for transplantation. (seattleu.edu)
- In addition to a shortage of transplant organs, several other causes also contribute to the gap between supply and demand, including the high expense for such surgeries and a shortage of doctors certified to perform them, Huang said. (ecns.cn)
Kidneys1
- Developed in the late 1980s by Folkert Belzer and James Southard for pancreas preservation, the solution soon displaced EuroCollins solution as the preferred medium for cold storage of livers and kidneys, as well as pancreas. (wikipedia.org)
Kidney2
- Paragonix has demonstrated a new system that intends to replace the ice and cooler method used for organ transportation, by flying a kidney more than a thousand miles. (medicaldevice-network.com)
- Kidney Assist Transporter Preservation and Transport of Organs is Silver Design Award winner in 2020 - 2021 Medical Devices and Medical Equipment Design Award Category. (adesignaward.com)
Centers2
- [ 1 ] With such constraints, preservation of organs for transport between centers becomes crucial in order to facilitate broader sharing of these limited-resource items. (medscape.com)
- The 4successful transport of a preserved donor organ from LifeLink of Puerto Rico to Florida underscores the hurdles that Organ Procurement Organizations and transplant centers conquer to securely deliver the precious gift of life. (businesswire.com)
Lung1
- Storing donor lungs for transplant at 10 degrees Celsius markedly increases the length of time the organ can live outside the body according to research led by a team of scientists at the Toronto Lung Transplant Program in the Ajmera Transplant Centre at the University Health Network. (news-medical.net)
Donation to transplantation1
- The maintenance of organ viability from donation to transplantation is a decisive factor for the adequate function and survival of the graft, especially in organs such as the pancreas, which is highly susceptible to ischemic damage. (frontierspartnerships.org)
Survival3
- Techniques for organ preservation serve to minimize this damage to promote optimal graft survival and function. (medscape.com)
- We have more than 20 years of experience within the transplant industry and are dedicated to providing more effective, clinically proven and innovative products that both increase the availability of acceptable donor organs and improve survival after transplantation. (adesignaward.com)
- Objectives/Hypothesis High rates of overall survival (OS) and laryngeal preservation were achieved in two sequential phase II clinical trials in patients with stage III/IV laryngeal squamous cell carcinoma (SCC). (wustl.edu)
Trends1
- What key trends are likely to emerge in the France Organ Preservation market in the coming years? (bdnews55.com)
20163
- EMAILWIRE.COM , February 20, 2018 ) According to the report Europe Organ Preservation Market , published by Market Data Forecast, the market is projected to reach USD 53 million by 2021, at a CAGR of 7% from 2016 to 2021. (emailwire.com)
- The Europe Organ Preservation Market was valued at USD 37 million as of 2016. (emailwire.com)
- The number of organ donors in China reached 2,866 in the first seven months of the year, an increase of 33 percent compared with the same period in 2016, according to Wang Haibo, director of the China Organ Transplant Response System, which coordinates organ distribution and sharing. (ecns.cn)
CAGR4
- The Organ Preservation market is expected to register a CAGR of 8.0% during the forecast period. (medgadget.com)
- Global organ preservation market was valued at $0.17 billion in 2017 and is expected to reach $0.31 billion by 2025 with a CAGR of 7.80% during the forecast period 2019-2025. (envisioninteligence.com)
- According to the report, the global Organ Preservation Solutions Market was valued at US$ 193.4 Mn in 2018 and is projected to expand at a CAGR of 10.5% from 2019 to 2027. (healthfirsto.com)
- Asia Pacific is likely to be a highly lucrative market for organ preservation solution expected to expand at a high CAGR during the forecast period. (healthfirsto.com)
20185
- Europe dominated the global organ preservation solutions market in 2018 and the trend is anticipated to continue during the forecast period. (healthfirsto.com)
- As per Organ Donation Statistics, 36,528 organ transplantation were performed in the year 2018 in the United States. (healthfirsto.com)
- The Custodial HTK segment held major share of the global organ preservation solutions market in 2018 and the trend is anticipated to continue during the forecast period. (healthfirsto.com)
- Europe dominated the global organ preservation solutions market in 2018, followed by North America. (healthfirsto.com)
- Europe accounted for major share of the global organ preservation solutions Market in 2018, followed by North America owing to increase in organ transplantation surgeries in the region. (healthfirsto.com)
Global organ3
- The global organ preservation market is majorly driven by the high prevalence of organ failures, increasing advancement in surgeries, increasing number of transplantation procedures, and growing penetration by market players. (medgadget.com)
- The Americas dominates the global organ preservation market owing to the increasing geriatric population, which eventually leads to the increasing patient pool because of their vulnerability to organ failures. (medgadget.com)
- In terms of region, the global organ preservation solutions market has been segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. (healthfirsto.com)
Thoracic2
- Our LS-A™ Abdominal Organ Transplant Solution and LS-T™ Thoracic Organ Transplant Solution - both in pre-clinical development - have outperformed the 'Gold Standard' solutions which are currently used globally. (opslgroup.com)
- A next generation organ preservation and cardioplegia solution for thoracic organs. (opslgroup.com)
Donors6
- However, the high cost of strategies and the lack of organ donors are the key factors that may hinder the development of the market in the coming years. (emailwire.com)
- Preservation has become a key challenge due to the increasing use of marginal donors, in whom the functionality of the organ is most affected ( 6 , 7 ). (frontierspartnerships.org)
- Organ donors in China are expected to exceed 5,000 this year, nearly twice the number in 2015, when voluntary donations became the only legal source of organs, the China Organ Transplantation Development Foundation said on Thursday. (ecns.cn)
- This could make China the country with second-largest number of organ donors this year, said Huang Jiefu, president of the foundation, part of the National Health and Family Planning Commission. (ecns.cn)
- The number of organ donors in China this year is expected to exceed 5,000, and more than 15,000 organ transplant surgeries are expected to be completed, said Wang, also a member of the foundation's council. (ecns.cn)
- As of July 16, more than 293,000 people had registered as potential organ donors, and more than 34,500 organs had been donated, according to the foundation. (ecns.cn)
Transplantation procedures1
- However, factors such as high cost of organ preservation and its transplantation procedures, unavailability of the suitable donor as well as the development of organs by stem cell therapy are likely to hamper the growth of the market. (medgadget.com)
20211
- Europe Organ Preservation Market is developing at an exceptionally quick pace to reach USD 53 million by 2021. (emailwire.com)
Surgeries1
- Organ Preservation solutions are used for preserving organs before transplantation surgeries. (healthfirsto.com)
Graft1
- In contrast, Histidine-Tryptophan-Ketoglutarate (HTK) and Celsior (CS) solutions, which were originally designed for cardiac graft protection, have the advantage of a much lower viscosity, providing more rapid cooling and better washout during organ procurement. (frontierspartnerships.org)
Outcomes2
- Several organ-preservation solutions are available, and these are being constantly modified to provide improved organ storage and outcomes. (medscape.com)
- In addition, OPSL has a carefully selected portfolio of products in early stage development aimed at enhancing the organ transplantation process to further improve patient and clinical outcomes. (opslgroup.com)
Late 1980s1
- Files contain some historical documents from the 1920s, the time in which the organ was built, but most records pertain to the preservation efforts of the late 1980s and early 1990s. (hclib.org)
Pancreas Transplantation1
- In this scenario, four preservation solutions are currently in use for pancreas transplantation. (frontierspartnerships.org)
Safe preservation2
- The breakthrough could have major implications for long-term safe preservation of everything from blood cells and organs to the food we eat. (impactlab.com)
- Advancements in cryobiology research can enable regular, safe preservation of organs. (organstasis.org)
Viability1
- This solution maintains organ viability, rapidly cool down the organ and minimizes cellular injury. (healthfirsto.com)
Solutions6
- Extensive research should be done preservation solutions to increase their efficacy to protect the organs from cellular damage and maintain its metabolic rate. (medgadget.com)
- They are also flushed with preservative solutions that are essential in resorting the normal organ functionality post-transplantation. (imarcgroup.com)
- The team behind OPSL have the experience and the knowledge required to create the new standard in organ transplant solutions. (opslgroup.com)
- University of Wisconsin cold storage solution remains what is often called the gold standard for organ preservation, despite the development of other solutions that are in some respects superior. (wikipedia.org)
- Market growth for organ preservation solutions will also be propelled by the rise in the number of elderly people worldwide since, risk of organ failure in people of this age group is higher. (healthfirsto.com)
- Also, it is a vintage preservation solution and hence has gained considerable popularity in the industry which has resulted in increasing preference for Custodiol over other solutions in the market. (healthfirsto.com)
Transplantations2
- Solid-organ transplantations have become the therapeutic option of choice for end-stage organ failure. (medscape.com)
- If everything goes well, China is expected to become the world leader in organ donations and transplantations by 2020," Huang said, giving no exact figures. (ecns.cn)
High cost of organ1
- The factors like limited medical reimbursements for organ donation and transplantation and the high cost of organ transplantation are hampering the market growth. (envisioninteligence.com)
Solution17
- All Paragonix AOP devices are natively integrated with our novel digital app, delivering real-time organ tracking data and monitoring logistics for transplant teams seeking a secure and centralized solution. (businesswire.com)
- Our report has categorized the market based on preservation solution, organ donation type, technique, organ type and end-user. (imarcgroup.com)
- What is the breakup of the market based on the preservation solution? (imarcgroup.com)
- UW solution was the first solution designed for use in organ transplantation, and became the first intracellular-like preservation medium. (wikipedia.org)
- The solution has also been used for hearts and other organs. (wikipedia.org)
- Potassium lactobionate: 100 mM KH2PO4: 25 mM MgSO4: 5 mM Raffinose: 30 mM Adenosine: 5 mM Glutathione: 3 mM Allopurinol: 1 mM Hydroxyethyl starch: 50 g/L HTK Solution (Histidine-tryptophan-ketoglutarate) Biostasis Organ transplant Southard JH, Belzer FO (1995). (wikipedia.org)
- As we delve into the intricate landscape of the organ preservation solution market, a sector vital for advancing healthcare through organ transplantation, it's evident that the market is on a trajectory of significant growth. (tbrc.info)
- The escalating prominence of organ transplantation emerges as a key driver propelling the organ preservation solution market. (tbrc.info)
- The organ preservation solution market is influenced by key players steering the industry's trajectory. (tbrc.info)
- Product innovation emerges as a defining trend in the organ preservation solution market, with companies focusing on developing cutting-edge products to fortify their positions. (tbrc.info)
- The organ preservation solution market exhibits intricate segmentation, reflecting diverse solution types, organ types, and techniques. (tbrc.info)
- In 2022, North America takes the lead as the largest region in the organ preservation solution market, showcasing the region's robust healthcare infrastructure. (tbrc.info)
- As we navigate the intricate landscape of the organ preservation solution market, projections indicate a robust future. (tbrc.info)
- Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. (frontierspartnerships.org)
- This solution enables the organ for proper storage, transportation, and transplantation into the recipient. (healthfirsto.com)
- North America is the second major revenue generating region in organ preservation solution market. (healthfirsto.com)
- Bacterial contamination of organ preservation solution used in transplant surgery. (cdc.gov)
Viable1
- Organ preservation refers to the procedure of preserving the viable organs harvested from the body of a donor to be later transplanted into the body of a receiver. (imarcgroup.com)
Multiple organ failures2
- This increasing older population is likely to lead to the rising patient population because of them being prone to multiple organ failures. (medgadget.com)
- Rising occurrences of multiple organ failures due to the growing prevalence of various chronic diseases, such as cardiovascular diseases, diabetes, and obesity, represent one of the key factors driving the Japan organ preservation market. (imarcgroup.com)
Clinical2
- Embracing this state-of-the-art preservation technology, alongside the clinical assistance provided by Paragonix, and our local recovery teams, aligns with our goal to improve lives by facilitating organ recovery for transplantation. (businesswire.com)
- Our findings suggest that cross-circulation can serve as a complementary approach to clinical EVLP to recover injured donor lungs that could not otherwise be utilized for transplantation, as well as a translational research platform for immunomodulation and advanced organ bioengineering. (nature.com)
Forecast period1
- What is the forecast period of the France Organ Preservation Market? (bdnews55.com)
Damage2
- Damage to organs during transplantation occurs in 2 phases: the warm ischemic phase and the cold ischemic phase. (medscape.com)
- Classic and exertional heatstroke cause acute injury and damage across numerous organ systems. (cdc.gov)
Insights3
- The discovery not only contributes to understanding the evolution of katydids but also offers insights into ancient insect anatomy and the preservation potential of soft internal structures in fossils. (scienceblog.com)
- This level of preservation is unprecedented, providing valuable insights into ancient insect anatomy and offering a rare opportunity to study the soft internal structures of an extinct species. (scienceblog.com)
- The report provides overall market insights for manufacturers, suppliers, distributors, and investors in the global France Organ Preservation market. (bdnews55.com)
LIVERguard1
- According to Paragonix, the LIVERguard system includes many of the features the company prides itself on, such as access real-time data on the device including a GPS tracker which tells the user exactly where the organ is at any given time. (medicaldevice-network.com)
Vivo2
- Pinezich, M. & Vunjak-Novakovic, G. Bioengineering approaches to organ preservation ex vivo. (nature.com)
- We are firmly rooted in medical science and our core business is in ex vivo organ preservation. (adesignaward.com)
Cardiovascular1
- Additionally, the increasing burden of diabetes, cardiovascular disorder, diabetic nephropathy, and obesity rate along with rising government initiatives for the research and development of innovative and advanced products are likely to enhance the growth of organ preservation in the North American region. (medgadget.com)
Fertility2
- Fertility preservation through assisted reproduction has undergone significant improvements. (medscape.com)
- Fertility preservation was not associated with mortality. (medscape.com)
Advancements1
- The factors like increasing government and NGO initiatives to encourage organ donation and rising cases of multiple organ failure in the aging population coupled with technological advancements in organ preservation are fuelling the market growth. (envisioninteligence.com)
Outlook4
- Furthermore, the Government of Japan (GoJ) is undertaking initiatives to promote organ donation, which is creating a positive outlook for the market. (imarcgroup.com)
- What is the current and future Europe Organ Preservation Market outlook? (emailwire.com)
- What is End-User perception and market outlook of Organ Preservation? (emailwire.com)
- Analysis and conclusions on the future Organ Preservation market outlook. (envisioninteligence.com)
Report5
- Recent competitive developments including M&A (Mergers and Acquisitions), Partnerships, and Product Innovations are provided in the Organ Preservation Market Analysis report. (envisioninteligence.com)
- The report provides France Organ Preservation market drivers and restraints. (bdnews55.com)
- The information and data provided in the report may be used by all stakeholders, students, consulting firms, research institutes, industry professionals, journalists, business researchers, etc. in the global France Organ Preservation market. (bdnews55.com)
- The global France Organ Preservation market research report includes Company Profile, Product Specifications, Production Capacity/Sales, Revenue, Price, and Gross Margin & Sales by product are all covered in this report. (bdnews55.com)
- This report provides an in-depth analysis of the organ extracts market in the EU. (researchandmarkets.com)
Puerto Rico2
- The recovery was managed by the expert staff of LifeLink of Puerto Rico, a non-profit Organ Procurement Organization (OPO). (businesswire.com)
- LifeLink of Puerto Rico works closely with donor hospitals throughout the territory to facilitate organ donation and save the lives of patients in need of lifesaving transplantation. (businesswire.com)
Ischemia1
- The injury an organ sustains during recovery, preservation, and transplantation occurs primarily as a result of ischemia and hypothermia. (medscape.com)
Additionally2
- Additionally, factors such as initiatives taken by government and NGO to encourage organ donation, availability of skilled personnel are likely to spur the growth of the market. (medgadget.com)
- Additionally, the increasing government support and increasing healthcare infrastructure along with the increasing demand for minimally invasive treatments are driving the growth of the Organ Preservation market in Europe. (medgadget.com)
Freezing1
- Heck, who knows - although this approach studiously avoids actual freezing, maybe it could prompt advances in the kind of long-term cryogenic preservation process that scientists, sci-fi authors, and, allegedly, Walt Disney have speculated about for years. (impactlab.com)
Technique1
- Organ transplantation has been the most successful and sophisticated technique that has been rising over the past 50 yrs. (medgadget.com)
Organizations1
- This photo is from the United States Red Cross Research Facility in Bethesda MD , one of the premier organizations focused upon organ preservation research. (organstasis.org)
20191
- Also, more than 113,000 people in the United States, are in the waiting list in the July 2019 for organ transplantation. (healthfirsto.com)