Organ Preservation: The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Organ Preservation Solutions: Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.Laryngectomy: Total or partial excision of the larynx.Raffinose: A trisaccharide occurring in Australian manna (from Eucalyptus spp, Myrtaceae) and in cottonseed meal.Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.Hypopharyngeal Neoplasms: Tumors or cancer of the HYPOPHARYNX.Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.Pharyngectomy: Surgical removal of a part of the pharynx. (Dorland, 28th ed)Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Brain Death: A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Preservation, Biological: The process of protecting various samples of biological material.Pancreas Transplantation: The transference of a pancreas from one human or animal to another.Cryopreservation: Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Mannitol: A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.Fertility Preservation: A method of providing future reproductive opportunities before a medical treatment with known risk of loss of fertility. Typically reproductive organs or tissues (e.g., sperm, egg, embryos and ovarian or testicular tissues) are cryopreserved for future use before the medical treatment (e.g., chemotherapy, radiation) begins.Reperfusion Injury: Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.Perfusion: Treatment process involving the injection of fluid into an organ or tissue.Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Hydroxyurea: An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Radiotherapy Dosage: The total amount of radiation absorbed by tissues as a result of radiotherapy.Adenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Insurance, Health, Reimbursement: Payment by a third-party payer in a sum equal to the amount expended by a health care provider or facility for health services rendered to an insured or program beneficiary. (From Facts on File Dictionary of Health Care Management, 1988)Glutathione: A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Kidney Transplantation: The transference of a kidney from one human or animal to another.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Tissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Cyclic Nucleotide Phosphodiesterases, Type 3: A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.Semen Preservation: The process by which semen is kept viable outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Food Preservation: Procedures or techniques used to keep food from spoiling.Multiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.Organ Size: The measurement of an organ in volume, mass, or heaviness.Organ Specificity: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.Organ of Corti: The spiral EPITHELIUM containing sensory AUDITORY HAIR CELLS and supporting cells in the cochlea. Organ of Corti, situated on the BASILAR MEMBRANE and overlaid by a gelatinous TECTORIAL MEMBRANE, converts sound-induced mechanical waves to neural impulses to the brain.Cold Ischemia: The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.Freeze Drying: Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Blood Preservation: The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).

Beta-glucan reflects liver injury after preservation and transplantation in dogs. (1/524)

Graft failure and extrahepatic organ complications, which frequently develop after transplantation, may be related to inflammatory mediators stimulated by endotoxin (ET). The role of endotoxemia after liver transplantation is controversial and may depend upon differences in the ET assay method used in the various contradicting studies. While the standard Limulus amebocyte lysate (LAL) is reactive for ET and beta-glucan, a novel turbidimetric assay method enables separate determinations of ET and beta-glucan. Beagle dogs undergoing orthotopic liver transplantation were divided into two groups. In Group I (n = 6) the grafts were transplanted immediately and in Group II (n = 6) grafts were preserved for 48 h in University of Wisconsin (UW) solution. Animals received cyclosporine immunosuppression and were followed for 14 days. Daily measurements of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were performed. Samples for ET and beta-glucan measurement were collected serially and processed using the turbidimetric assay method. While no graft failure was seen in Group I, three of six Group II animals died from graft failure within 1 day after transplantation. Preservation and reperfusion injury was much more severe in the Group II grafts than in Group I grafts. While endotoxemia could not be detected, postoperative beta-glucan levels (undetectable pretransplant) were seen in both groups. Beta-glucan levels were much higher in Group II grafts than in Group I grafts, and correlated with the severity of liver damage. In conclusion, this study shows that beta-glucan, instead of ET, appears during the early posttransplant period. We believe that posttransplant elevation of beta-glucan is related to liver damage, especially endothelial damage by preservation and reperfusion.  (+info)

Tissue donation after death in the accident and emergency department: an opportunity wasted? (2/524)

OBJECTIVE: To investigate whether the accident and emergency department (A&E) is a potential source of tissues for donation, from non-heart beating donors (NHBDs). METHODS: A telephone survey of 30 A&E departments was conducted to determine current tissue harvesting practices from NHBDs. The potential number of tissue donors in our own medium sized district general hospital A&E department was estimated. Senior nursing staff were asked to complete a questionnaire to establish their knowledge, attitudes, and experience of tissue harvesting from NHBDs. RESULTS: Only seven of the 30 A&E departments surveyed (23%) had an active involvement in requesting tissue donation after a sudden death. Several others had limited experience. The level of involvement was unrelated to department size. In our own A&E department, there were 110 deaths in 1995. Tissue donation had occurred on just three occasions. However, departmental staff attitudes towards reducing this shortfall were positive. CONCLUSIONS: The A&E department is a resource of tissues for donation, which is currently under used.  (+info)

Intravenous glycine improves survival in rat liver transplantation. (3/524)

In situ manipulation by touching, retracting, and moving liver lobes gently during harvest dramatically reduces survival after transplantation (P. Schemmer, R. Schoonhoven, J. A. Swenberg, H. Bunzendahl, and R. G. Thurman. Transplantation 65: 1015-1020, 1998). The development of harvest-dependent graft injury upon reperfusion can be prevented with GdCl3, a rare earth metal and Kupffer cell toxicant, but it cannot be used in clinical liver transplantation because of its potential toxicity. Thus the effect of glycine, which prevents activation of Kupffer cells, was assessed here. Minimal dissection of the liver for 12 min plus 13 min without manipulation had no effect on survival (100%). However, gentle manipulation decreased survival to 46% in the control group. Furthermore, serum transaminases and liver necrosis were elevated 4- to 12-fold 8 h after transplantation. After organ harvest, the rate of entry and exit of fluorescein dextran, a dye confined to the vascular space, was decreased about twofold, indicating disturbances in the hepatic microcirculation. Pimonidazole binding, which detects hypoxia, increased about twofold after organ manipulation, and Kupffer cells isolated from manipulated livers produced threefold more tumor necrosis factor-alpha after lipopolysaccharide than controls. Glycine given intravenously to the donor increased the serum glycine concentration about sevenfold and largely prevented the effect of gentle organ manipulation on all parameters studied. These data indicate for the first time that pretreatment of donors with intravenous glycine minimizes reperfusion injury due to organ manipulation during harvest and after liver transplantation.  (+info)

Organ transplantation--then and now. (4/524)

The last 25 years have seen amazing progress in transplantation--from the development of techniques for immunosuppression to methods for organ removal and preservation. Our distinguished authors focus on these developments and discuss how the momentum seen during the last quarter century can be accelerated.  (+info)

A study on continuous low-flow perfusion with low-potassium dextran for donor isolated lung preservation. (5/524)

OBJECTIVE: To test the validity of continuous low-flow perfusion with low-potassium dextran (LPD) to preserve rabbit lung. METHODS: Isolated rabbit lungs were preserved for eight hours either in Ringer's solution by simple storage (Group I) or in continuous low-flow perfusion with LPD (Group II). After preservation, lung functions were assessed to compare these two methods. RESULTS: The water gain in Group I was higher than that in Group II. During reperfusion, the functional test values for the immersed lungs were lower than those for the perfused lungs. The lipid peroxidation product (MDA) was significantly decreased in perfused lungs during reperfusion. CONCLUSIONS: Low-flow perfusion with LPD is better than immersion for the lung preservation.  (+info)

The effects of mannitol, albumin, and cardioplegia enhancers on 24-h rat heart preservation. (6/524)

During 24 h in vitro heart preservation and reperfusion, tissue damage occurs that seriously reduces cardiac function. Prevention of free radical production during preservation and reperfusion of ischemic tissue using free radical scavengers is of primary importance in maintaining optimal heart function in long-term preservation protocols. We examined whether mannitol (68 mM) and albumin (1.4 microM) in combination with other cardioplegia enhancers decreased free radical formation and edema and increased cardiac function during 24-h cold (5 degrees C) heart preservation and warm (37 degrees C) reperfusion in the Langendorff-isolated rat heart. The performance of mannitol-treated hearts was significantly decreased compared with that of hearts without mannitol treatment after 24 h of preservation with regard to recovery of diastolic pressure, contractility (+dP/dt), relaxation (-dP/dt), myocardial creatine kinase release, coronary flow, and lipid peroxidation. Albumin-treated hearts demonstrated higher cardiac function (contractility and coronary flow especially) than hearts not treated with albumin or hearts treated with mannitol, and this appears to be due to the positive effects of increased cellular metabolism and the enhancement of membrane stability.  (+info)

Endothelium-dependent relaxation of canine pulmonary artery endothelium after prolonged preservation. (7/524)

OBJECTIVE: Experiments were designed to investigate the effect of Euro-Collins (EC) solution and University of Wisconsin (UW) solution on function of pulmonary arterial endothelium. METHODS: Third order canine pulmonary artery segments were preserved in cold (4 degrees C) UW (group 1, n = 8) or EC (group 2, n = 9) solutions for 16 hours. The preserved (group 1 and 2) and control (group 3, n = 7) pulmonary arterial segments with and without endothelium were studied in vitro in organ chambers to measure isometric tension. RESULTS: The endothelium-dependent relaxation to acetylcholine and adenosine diphosphate of group 1 and 3 were significantly better than those of group 2. CONCLUSIONS: We concluded that endothelium-dependent relaxation of canine pulmonary arterial endothelium to receptor-dependent acetylcholine and adenosine diphosphate were impaired after preservation with Euro-Collins solution. However, endothelium-dependent relaxation of pulmonary segments were well maintained after preservation with University of Wisconsin solution.  (+info)

Controlling transplant vasculopathy in cryopreserved vein grafts with polyethylene glycol and glutathione during transport. (8/524)

BACKGROUND: the biological characteristics of cryopreserved allografts are poorly understood, although many factors are known to influence their outcome. This study examines the development of transplant vasculopathy in both fresh and cryopreserved vein allografts and specifically assesses the efficacy of a transport solution containing 10% polyethylene glycol and 10 microM glutathione (PEG/GSH). METHODS: jugular veins were harvested from control donor rabbits and transplanted as interposition carotid bypass grafts in 30 New Zealand White (NZW) rabbits. Ten received the fresh jugular veins (fresh). Ten animals received jugular veins which had been harvested, transported in a physiological solution, cryopreserved and stored in a standard fashion (cryopreserved). Ten animals received jugular veins which had been harvested, transported in the same solution with the addition of PEG/GSH, cryopreserved and stored in a standard fashion (PEG/GSH). Cryopreserved jugular veins were stored for 6 weeks before transplantation. All animals were sacrificed 28 days postoperatively. Vein grafts were perfusion-fixed and wall dimensions were determined by planimetry. RESULTS: all transplanted grafts were patent at harvest. The control cryopreserved vein grafts showed a 54% increase in mean intimal thickness (63+/-10 micron vs. 41+/-3 micron p<0.05) but no change in mean medial thickness (125+/-9 micron vs. 119+/-13 micron; p = N.S. ) compared to the fresh allograft. Transport of the grafts in PEG/GSH solution resulted in the abolition of the increase in intimal thickness (41+/-4 micron; p <0.01) associated with cryopreservation without a change in medial thickness (140+/-15 micron; p = N.S.) compared to the cryopreserved allograft. CONCLUSION: cryopreserved vein grafts develop significant intimal hyperplasia compared to freshly transplanted grafts. The use of PEG/GSH in the transport solution significantly reduces this transplant graft intimal hyperplasia to that which develops in fresh grafts and may lead to improvements in the clinical use of cryopreserved veins.  (+info)

  • This project will form the basis for further testing in a Phase II SBIR application for recovery and preservation of extended warm ischemic livers in a pre-clinical animal transplant model. (
  • Impressive advances in organ procurement, surgical technique, post-operative care, and immunosuppression have significantly reduced transplant-related morbidity and mortality transforming an extraordinary event in a safe and routinely performed procedure. (
  • Publications] Hasegawa Y, et al: 'Effect of short-term coronary perfusion after cold strage for long-term heart preservation : A comparative study of University of Wisconsin solution and diluted blood as the perfusate' Transplant Proc. (
  • In addition, we designed an original apparatus for continuous coronary perfusion preservation instead of the Langendorff's method This apparatus has such characteristics as hypothermic management, variable perfusion pressure, non-dependent energy source and portable. (
  • Other factors such as the growing government and NGO initiatives to encourage organ donation along with the increasing awareness of organ donations assist the market development. (
  • NTG similarly enhanced preservation of hearts stored in University of Wisconsin solution, the clinical standard for preservation. (
  • Incorporating these features in a system based on existing standard surgical and organ sharing procedures and which is able to work stand-alone for 24 h, weighing less than 23 kg, could successfully implement this technique into every day clinical practise. (
  • According to the National Kidney Foundation, in 2016, around 121,678 people are waiting for lifesaving organ transplants in the U.S., among which, approximately 100,791 people are waiting for kidney transplants. (
  • North America dominates the global Organ Preservation Market, and it is primarily attributed to the rising geriatric population leading to the higher occurrence of organ failures. (
  • The Global Organ Preservation Market is expected to grow at a high CAGR during the forecasting period (2019-2026). (
  • Other stimulators of the NO pathway, including nitroprusside, L-arginine, or 8-bromoguanosine 3',5' monophosphate, also enhanced graft survival, whereas the competitive NO synthase antagonist NG-monomethyl-L-arginine was associated with poor preservation. (
  • However, they are largely under utilized due to poor preservation by the current method of simple cold storage (SCS). (
  • We are now planning the evaluation of transplanted hearts by the force transducer and long-term heart preservation of more than 12-hr. (
  • Publications] Ogiwara H, et al: 'A comparison of the University of Wisconsin and the modified Kawakami solution for initial flush and coronary perfusion in long-term canine heart preservation. (
  • Long-term heart preservation by the combined method of simple immersion and coronary perfusion. (
  • The effect of initial flush for cooling and coronary vascular washout in heart preservation. (
  • This system can assess whether grafts experience primary non-function, a major cause of failure in DCD organs. (
  • While the ScubaTx device will be compatible with multiple organ types, the initial clinical focus will be on pancreas and kidney. (
  • Rise in incidences of organ failure in kidney, liver and heart patients across the globe is augmenting the demand for organ transplant procedures. (
  • Moreover, rising incidences of kidney, liver and other organ failure drives the need of transplant surgeries and increase the demand of organ preservation solutions in the market. (
  • This article discusses the pathophysiology, techniques, and principles of organ preservation, and idescribes various preservation solutions currently used for kidney , liver , pancreas , small-bowel , lung , and heart transplantations. (
  • By Organ type, Kidney holds the largest market share and lungs is expected to grow at the highest CAGR in the forecast period. (
  • The machine had already been tested using a human kidney and animal organs. (
  • The first human organ to be connected to the machine was a kidney, which was kept functioning for almost 24 hours in a test this summer at the University of Chicago. (
  • 10. The method of claim 1 or 6, wherein the organ is kidney, liver, heart, skin and lung. (
  • 11. The method of claim 1 or 6, wherein the organ is a kidney. (
  • Preservation of kidney accounted for the biggest market share in 2016 owing to the increasing aging population coupled with increasing prevalence of kidney failures. (
  • Kidney preservation holds the most significant share in the organ preservation market due to the rising elderly population coupled with the rise in the occurrence of kidney failures. (
  • The growing prevalence of cardiovascular diseases and the increasing cases of kidney failure are likely to enhance the growth of organ preservation. (
  • The aim of this study was to compare these preservation methods on kidney graft outcomes. (
  • Rising prevalence of chronic kidney & heart disease, augmented number of end stage organ failure, chronic obstructive pulmonary disease (COPD) across the globe, technological advancements in organ preservation supply chain coupled with the rising demand for healthcare products are the major factors impelling the market growth. (
  • Factors such as enhanced healthcare spending, rising geriatric population, practice of unhealthy lifestyle & lack of physical inactivity, consumption of alcohol, smoking tobacco and excessive exposure to polluted environment are the crucial factors that develop chronic kidney, heart and lung diseases are supposed to augment the demand for organ preservation products and services. (
  • On the basis of Organ Type, Kidney held the largest market share during the historical period. (
  • The technique, persufflation, submerges donor organs in saline solution and gently streams oxygenated air through the vessels of the chilled organs to increase viability from just a few hours to 24 hours or longer. (
  • This solutions maintains organ viability, rapidly cool down the organ and minimizes cellular injury. (
  • it is a superior means of preserving organs out of body and provides a way to assess the viability of the organ. (
  • In previous studies with up to four years of follow-up data, Stratta has shown that success rates with these organs are equivalent to those of conventional donors, in part because of appropriate donor and recipient matching through using the pump to assess viability and function. (
  • Maintaining organ viability during preservation is an important factor for a successful outcome. (
  • One component essential for tissue viability that is absent from current cold static preservation methods is tissue oxygenation. (
  • Hypothermia is the principal element used to prolong organ viability ex vivo, but paradoxically also induces cellular edema through inhibition of energy-dependent adenosine triphosphatases (ATPases). (
  • We demonstrate that the strategy effectively maintained cell viability, transcriptome integrity, cell population heterogeneity, and transcriptome landscape stability for samples after up to 3 days of preservation. (
  • Traditional static cold preservation cannot prevent ischemia/reperfusion injury, the low temperature itself is damaging and viability testing is limited. (
  • Indeed, the rodent organs stored at -4°C (under moderate pressure) were of comparable viability to those stored at 0°C (at atmospheric pressure) and there was significant injury at the lowest temperatures (under the highest pressures). (
  • The duration of ex vivo reperfusion should be specified to allow adequate assessment of organ function and viability. (
  • Preservation of organs for much longer than 4C6 h leads to increased ROS amounts, ATP depletion, Na+/K+ ATPase modifications, mitochondrial disturbances, deposition of xanthine oxidase, and dysregulation of Ca2+ homeostasis which will impact mobile viability [2 adversely, (
  • Amid the COVID-19 crisis, the global market for Organ Preservation Solutions estimated at US$195.6 Million in the year 2020, is projected to reach a revised size of US$305.9 Million by 2027, growing at a CAGR of 6.6% over the analysis period 2020-2027. (
  • The Organ Preservation Solutions market in the U.S. is estimated at US$57.8 Million in the year 2020. (
  • Paragonix in January 2020 announced the clearance of a Pre-Marketing Notification (510(k) with the U.S. Food and Drug Administration (FDA) for the Donor Lung Preservation System (LUNGguard). (
  • Global Organ Preservation Solution Market Report 2020 by Key Players, Types, App. (
  • The Organ Preservation Solution market is expected to grow from USD X.X million in 2020 to USD X.X million by 2026, at a CAGR of X.X% during the forecast period. (
  • In the report, Organ Preservation market's revenue is estimated at USD XX million in 2020 and is expected to reach USD XX million by the end of 2028, rising at a CAGR of XX percent. (
  • adds "Global Organ Preservation Market Research Report 2020 Analysis and Forecast 2025" reports to its database. (
  • Further, rising geriatric population, hypertension, unhealthy lifestyle and increasing government initiatives creating awareness and importance of organ donation are some of the factors driving the market and anticipated to infuse growth in the market for Organ Preservation during the forecast period of 2020-2025. (
  • According to the report, the global Organ Preservation Solutions Market was valued at US$ 193.4 Mn in 2018 and is projected to expand at a CAGR of 10.5% from 2019 to 2027. (
  • Europe dominated the global organ preservation solutions market in 2018 and the trend is anticipated to continue during the forecast period. (
  • The Custodial HTK segment held major share of the global organ preservation solutions market in 2018 and the trend is anticipated to continue during the forecast period. (
  • Europe dominated the global organ preservation solutions market in 2018, followed by North America. (
  • Asia Pacific is likely to be a highly lucrative market for organ preservation solution expected to expand at a high CAGR during the forecast period. (
  • The Global Organ Preservation Market is worth USD 180 million in 2016 and estimated to grow at a CAGR of 7.8%, to reach USD 262 million by 2021. (
  • AsiaNewsWire.Net , July 17, 2017 ) According to Publisher, the Global Organ Preservation market is estimated at $153.93 million in 2015 and is expected to reach $274.19 million by 2022 growing at a CAGR of 8.7% from 2015 to 2022. (
  • Europe is the largest market for Organ Preservation and Asia Pacific is anticipated to register significant CAGR during the forecast period. (
  • However, demand for lung preservation is estimated to grow with highest CAGR owing to increasing incidence of having Chronic Obstructive Pulmonary Disease and other life-threatening lung diseases in large number of people across all the regions. (
  • New selection criteria for better larynx organ preservation according to the DeLOS-II trial. (
  • Transoral laser microsurgery (TLM) for organ preservation in larynx/hypopharynx cancer. (
  • With a median follow-up time of 3 years, the estimated larynx preservation rate was 70.3 percent in the TPF-treated patients and 57.5 percent in the PF-treated patients. (
  • However, they caution that "Because we proposed treatment to a select popula¬tion of patients with only larynx and hypopharynx cancer and this trial was especially designed for organ preservation, we cannot gen¬eralize the findings to all locally advanced head and neck cancers. (
  • Raol N, Hutcheson KA, Lewin JS, Kupferman ME (2013) Surgical Management of the Non-functional Larynx after Organ Preservation Therapy. (
  • The results of the VA study demonstrated that a strategy of induction chemotherapy followed by definitive radiation therapy was an effective approach for larynx preservation without compromising a patient's overall survival compared to total laryngectomy. (
  • They comprised an organ-holding chamber, pulsatile pump for circulation of the perfusate, means of maintaining hypothermia, and several controls. (
  • BACKGROUND: Hypothermia-induced changes in endothelial cell (EC) morphology and function after organ storage may influence the initial outcome and development of transplant-associated coronary artery disease. (
  • Creating hypothermia by reducing the organ temperature may help preservation, but different body organs need precise and appropriate storage environments to maintain their anatomical and physiological processes. (
  • This invention also discloses methods for preserving and/or resuscitating organs in live. (
  • This invention also discloses methods for preserving and/or resuscitating organs in live (nonbrain-dead) patients, allowing for additional time to stabilize the patient's condition. (
  • Methods and compositions for reducing, preventing or reversing organ damage and/or enhancing organ preservation by administration of a peroxisome-proliferator activated receptor-alpha (PPARα) agonist to the organ. (
  • METHODS: In a pig liver transplant model, we compared the outcome following either conventional cold preservation or warm preservation. (
  • Our unique combination of primary and secondary research methods has helped us spot hidden business opportunities on the global organ preservation market, in addition to collecting significant market participant's perspectives and reliable market data. (
  • Now in its thoroughly revised, updated Fifth Edition, this volume is a comprehensive, practical reference on contemporary methods of disinfection, sterilization, and preservation and their medical, surgical, and public health applications. (
  • The report also includes profiles and for some of the leading companies in the Organ Preservation Solutions Market, with a focus on this segment of these companies' operations. (
  • The report provides a list of all the key players in the organ preservation market along with a detailed analysis of the strategies that are being implemented by the companies. (
  • The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism). (
  • It is for this reason that techniques and instruments were developed for the preservation of viable organs. (
  • We hope to contribute to healthcare through the development of a novel technology to expand the supply of available organs. (
  • The growth in the number of patients wanting or waiting for a transplant has outpaced the supply of available organs. (
  • Most solid-organ transplantations are now performed as the therapeutic option of choice. (
  • Hypothermic temperature effects on organ survival and restoration. (
  • The organ is perfused with a plasma or plasma derivative containing fluid at low temperature, with the organ being contained in a chamber which functions at the same time as the oxygenator for the oxygenation of the perfusate. (
  • The temperature-controlled hot air procedure is used to destroy insect pests in organ parts, wooden objects or furniture by gradually heating them to 55°C in a controlled process. (
  • Moreover the interdisciplinary concepts changed to more personalized compositions and without neglecting the strong evidence of non-surgical multimodality treatment approaches, surgery as a centre discipline in organ preservation is gaining relevance according to rising popularity of transoral access due to new IT and engineering developments. (
  • Surgical organ preservation in oropharynx carcinoma. (
  • It is divided into three main sections: Organ Preservation, Organ Harvesting and Surgical Techniques. (
  • Other criteria are needed to identify patients most likely to benefit from early surgical resection/salvage after organ preservation. (
  • yet despite best efforts, demand for organs far outstrips supply. (
  • Hyperacute rejection occurs when the patient's body has already produced a large number of antibodies (proteins manufactured by the immune system to battle disease and infection) that immediately recognize the antigens from the donor organ. (
  • As the immune system initiates a response to the antigens in the donor organ, specific immune cells in the blood begin to attack. (
  • Although this type of rejection is rare, when it occurs, the donor organ slowly deteriorates despite all efforts at immunosuppression. (
  • Organ preservation appears oncologically safe for selected rectal cancer patients with a cCR or near cCR after neoadjuvant chemoradiation when applying strict selection criteria and frequent follow-up, including endoscopy and MRI. (