The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
Total or partial excision of the larynx.
A trisaccharide occurring in Australian manna (from Eucalyptus spp, Myrtaceae) and in cottonseed meal.
Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
Tumors or cancer of the HYPOPHARYNX.
A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.
Surgical removal of a part of the pharynx. (Dorland, 28th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The process of protecting various samples of biological material.
The transference of a pancreas from one human or animal to another.
Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
A method of providing future reproductive opportunities before a medical treatment with known risk of loss of fertility. Typically reproductive organs or tissues (e.g., sperm, egg, embryos and ovarian or testicular tissues) are cryopreserved for future use before the medical treatment (e.g., chemotherapy, radiation) begins.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Treatment process involving the injection of fluid into an organ or tissue.
The transference of a part of or an entire liver from one human or animal to another.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
The transference of a heart from one human or animal to another.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
The transference of a kidney from one human or animal to another.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Transference of an organ between individuals of the same species or between individuals of different species.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
The process by which semen is kept viable outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Procedures or techniques used to keep food from spoiling.
A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
The measurement of an organ in volume, mass, or heaviness.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
The spiral EPITHELIUM containing sensory AUDITORY HAIR CELLS and supporting cells in the cochlea. Organ of Corti, situated on the BASILAR MEMBRANE and overlaid by a gelatinous TECTORIAL MEMBRANE, converts sound-induced mechanical waves to neural impulses to the brain.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products.
Elements of limited time intervals, contributing to particular results or situations.
The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).

Beta-glucan reflects liver injury after preservation and transplantation in dogs. (1/524)

Graft failure and extrahepatic organ complications, which frequently develop after transplantation, may be related to inflammatory mediators stimulated by endotoxin (ET). The role of endotoxemia after liver transplantation is controversial and may depend upon differences in the ET assay method used in the various contradicting studies. While the standard Limulus amebocyte lysate (LAL) is reactive for ET and beta-glucan, a novel turbidimetric assay method enables separate determinations of ET and beta-glucan. Beagle dogs undergoing orthotopic liver transplantation were divided into two groups. In Group I (n = 6) the grafts were transplanted immediately and in Group II (n = 6) grafts were preserved for 48 h in University of Wisconsin (UW) solution. Animals received cyclosporine immunosuppression and were followed for 14 days. Daily measurements of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were performed. Samples for ET and beta-glucan measurement were collected serially and processed using the turbidimetric assay method. While no graft failure was seen in Group I, three of six Group II animals died from graft failure within 1 day after transplantation. Preservation and reperfusion injury was much more severe in the Group II grafts than in Group I grafts. While endotoxemia could not be detected, postoperative beta-glucan levels (undetectable pretransplant) were seen in both groups. Beta-glucan levels were much higher in Group II grafts than in Group I grafts, and correlated with the severity of liver damage. In conclusion, this study shows that beta-glucan, instead of ET, appears during the early posttransplant period. We believe that posttransplant elevation of beta-glucan is related to liver damage, especially endothelial damage by preservation and reperfusion.  (+info)

Tissue donation after death in the accident and emergency department: an opportunity wasted? (2/524)

OBJECTIVE: To investigate whether the accident and emergency department (A&E) is a potential source of tissues for donation, from non-heart beating donors (NHBDs). METHODS: A telephone survey of 30 A&E departments was conducted to determine current tissue harvesting practices from NHBDs. The potential number of tissue donors in our own medium sized district general hospital A&E department was estimated. Senior nursing staff were asked to complete a questionnaire to establish their knowledge, attitudes, and experience of tissue harvesting from NHBDs. RESULTS: Only seven of the 30 A&E departments surveyed (23%) had an active involvement in requesting tissue donation after a sudden death. Several others had limited experience. The level of involvement was unrelated to department size. In our own A&E department, there were 110 deaths in 1995. Tissue donation had occurred on just three occasions. However, departmental staff attitudes towards reducing this shortfall were positive. CONCLUSIONS: The A&E department is a resource of tissues for donation, which is currently under used.  (+info)

Intravenous glycine improves survival in rat liver transplantation. (3/524)

In situ manipulation by touching, retracting, and moving liver lobes gently during harvest dramatically reduces survival after transplantation (P. Schemmer, R. Schoonhoven, J. A. Swenberg, H. Bunzendahl, and R. G. Thurman. Transplantation 65: 1015-1020, 1998). The development of harvest-dependent graft injury upon reperfusion can be prevented with GdCl3, a rare earth metal and Kupffer cell toxicant, but it cannot be used in clinical liver transplantation because of its potential toxicity. Thus the effect of glycine, which prevents activation of Kupffer cells, was assessed here. Minimal dissection of the liver for 12 min plus 13 min without manipulation had no effect on survival (100%). However, gentle manipulation decreased survival to 46% in the control group. Furthermore, serum transaminases and liver necrosis were elevated 4- to 12-fold 8 h after transplantation. After organ harvest, the rate of entry and exit of fluorescein dextran, a dye confined to the vascular space, was decreased about twofold, indicating disturbances in the hepatic microcirculation. Pimonidazole binding, which detects hypoxia, increased about twofold after organ manipulation, and Kupffer cells isolated from manipulated livers produced threefold more tumor necrosis factor-alpha after lipopolysaccharide than controls. Glycine given intravenously to the donor increased the serum glycine concentration about sevenfold and largely prevented the effect of gentle organ manipulation on all parameters studied. These data indicate for the first time that pretreatment of donors with intravenous glycine minimizes reperfusion injury due to organ manipulation during harvest and after liver transplantation.  (+info)

Organ transplantation--then and now. (4/524)

The last 25 years have seen amazing progress in transplantation--from the development of techniques for immunosuppression to methods for organ removal and preservation. Our distinguished authors focus on these developments and discuss how the momentum seen during the last quarter century can be accelerated.  (+info)

A study on continuous low-flow perfusion with low-potassium dextran for donor isolated lung preservation. (5/524)

OBJECTIVE: To test the validity of continuous low-flow perfusion with low-potassium dextran (LPD) to preserve rabbit lung. METHODS: Isolated rabbit lungs were preserved for eight hours either in Ringer's solution by simple storage (Group I) or in continuous low-flow perfusion with LPD (Group II). After preservation, lung functions were assessed to compare these two methods. RESULTS: The water gain in Group I was higher than that in Group II. During reperfusion, the functional test values for the immersed lungs were lower than those for the perfused lungs. The lipid peroxidation product (MDA) was significantly decreased in perfused lungs during reperfusion. CONCLUSIONS: Low-flow perfusion with LPD is better than immersion for the lung preservation.  (+info)

The effects of mannitol, albumin, and cardioplegia enhancers on 24-h rat heart preservation. (6/524)

During 24 h in vitro heart preservation and reperfusion, tissue damage occurs that seriously reduces cardiac function. Prevention of free radical production during preservation and reperfusion of ischemic tissue using free radical scavengers is of primary importance in maintaining optimal heart function in long-term preservation protocols. We examined whether mannitol (68 mM) and albumin (1.4 microM) in combination with other cardioplegia enhancers decreased free radical formation and edema and increased cardiac function during 24-h cold (5 degrees C) heart preservation and warm (37 degrees C) reperfusion in the Langendorff-isolated rat heart. The performance of mannitol-treated hearts was significantly decreased compared with that of hearts without mannitol treatment after 24 h of preservation with regard to recovery of diastolic pressure, contractility (+dP/dt), relaxation (-dP/dt), myocardial creatine kinase release, coronary flow, and lipid peroxidation. Albumin-treated hearts demonstrated higher cardiac function (contractility and coronary flow especially) than hearts not treated with albumin or hearts treated with mannitol, and this appears to be due to the positive effects of increased cellular metabolism and the enhancement of membrane stability.  (+info)

Endothelium-dependent relaxation of canine pulmonary artery endothelium after prolonged preservation. (7/524)

OBJECTIVE: Experiments were designed to investigate the effect of Euro-Collins (EC) solution and University of Wisconsin (UW) solution on function of pulmonary arterial endothelium. METHODS: Third order canine pulmonary artery segments were preserved in cold (4 degrees C) UW (group 1, n = 8) or EC (group 2, n = 9) solutions for 16 hours. The preserved (group 1 and 2) and control (group 3, n = 7) pulmonary arterial segments with and without endothelium were studied in vitro in organ chambers to measure isometric tension. RESULTS: The endothelium-dependent relaxation to acetylcholine and adenosine diphosphate of group 1 and 3 were significantly better than those of group 2. CONCLUSIONS: We concluded that endothelium-dependent relaxation of canine pulmonary arterial endothelium to receptor-dependent acetylcholine and adenosine diphosphate were impaired after preservation with Euro-Collins solution. However, endothelium-dependent relaxation of pulmonary segments were well maintained after preservation with University of Wisconsin solution.  (+info)

Controlling transplant vasculopathy in cryopreserved vein grafts with polyethylene glycol and glutathione during transport. (8/524)

BACKGROUND: the biological characteristics of cryopreserved allografts are poorly understood, although many factors are known to influence their outcome. This study examines the development of transplant vasculopathy in both fresh and cryopreserved vein allografts and specifically assesses the efficacy of a transport solution containing 10% polyethylene glycol and 10 microM glutathione (PEG/GSH). METHODS: jugular veins were harvested from control donor rabbits and transplanted as interposition carotid bypass grafts in 30 New Zealand White (NZW) rabbits. Ten received the fresh jugular veins (fresh). Ten animals received jugular veins which had been harvested, transported in a physiological solution, cryopreserved and stored in a standard fashion (cryopreserved). Ten animals received jugular veins which had been harvested, transported in the same solution with the addition of PEG/GSH, cryopreserved and stored in a standard fashion (PEG/GSH). Cryopreserved jugular veins were stored for 6 weeks before transplantation. All animals were sacrificed 28 days postoperatively. Vein grafts were perfusion-fixed and wall dimensions were determined by planimetry. RESULTS: all transplanted grafts were patent at harvest. The control cryopreserved vein grafts showed a 54% increase in mean intimal thickness (63+/-10 micron vs. 41+/-3 micron p<0.05) but no change in mean medial thickness (125+/-9 micron vs. 119+/-13 micron; p = N.S. ) compared to the fresh allograft. Transport of the grafts in PEG/GSH solution resulted in the abolition of the increase in intimal thickness (41+/-4 micron; p <0.01) associated with cryopreservation without a change in medial thickness (140+/-15 micron; p = N.S.) compared to the cryopreserved allograft. CONCLUSION: cryopreserved vein grafts develop significant intimal hyperplasia compared to freshly transplanted grafts. The use of PEG/GSH in the transport solution significantly reduces this transplant graft intimal hyperplasia to that which develops in fresh grafts and may lead to improvements in the clinical use of cryopreserved veins.  (+info)

[100 Pages Report] Check for Discount on Global Hypothermic Machine Perfusion Preservation Sales Market Report 2021 report by QYResearch Group. Notes: Sales, means the sales volume of Hypothermic Machine Perfusion...
Adequate preservation of renal allografts for transplantation is important for maintaining and improving transplant outcomes. There are two prevalent methods: hypothermic machine perfusion and static cold storage. The preferred method of storage, however, remains controversial. The objective was to review systematically the evidence comparing outcomes from these two modalities. ...
The shortage of donor organs for liver transplantation requires investigations into expanding the donor pool. Non-heart beating donor (NHBD) livers are an untapped source of organs. NHBD organs are those that have had a period of warm ischemia prior to cold preservation. A main concern of NHBD livers is that there is a depletion of energy stores during the warm ischemia and subsequent cold storage. This study is to investigate the use of hypothermic machine perfusion to regenerate energy stores in the liver during 5hr storage and after 1hr rewarming in a rat transplantation model. Results will be compared with control. (no warm ischemia) and simple cold stored tissues.. Copyright © 2003 by ASME ...
Transplant surgeons at UC Healths University of Cincinnati (UC) Medical Center have performed the first-ever liver transplant in the United States with an organ preserved using portable hypothermic machine perfusion. The technology, which had been under development for several years, is designed to circulate a specially formulated, cold-temperature medical solution throughout a donor liver during its journey from the point of donation to surgical transplantation into a recipient.. This active preservation device was invented to improve upon traditional static cold preservation, which stores the liver in a cool box filled with ice. Static cold storage has been the standard of care for liver preservation since the first successful liver transplant was performed in the United States in 1967.. The procedure at UC Health was done as part of the first multicenter clinical trial comparing portable hypothermic machine preservation of donated livers with livers placed in static cold storage prior to ...
TY - JOUR. T1 - Impact of 24 h continuous hypothermic perfusion on heart preservation by assessment of oxidative stress. AU - Fitton, Torin P.. AU - Wei, Chiming. AU - Lin, Ruxian. AU - Bethea, Brian T.. AU - Barreiro, Christopher J.. AU - Amado, Luciano. AU - Gage, Fred. AU - Hare, Joshua. AU - Baumgartner, William A.. AU - Conte, John V.. PY - 2004/9/23. Y1 - 2004/9/23. N2 - Introduction: Despite investigating numerous solutions, additives, and techniques over the last two decades, extending donor heart preservation beyond 4-6 h has not been achieved. Hypothermic heart preservation (HP) induces oxidative stress (OS) with reactive oxygen species (ROS) production, causing DNA cleavage and impairing repair. Quantification of cardiomyocyte concentrations of DNA damage by-products (8-oxoG) and mismatch repair enzymes (MYH, OGG-1, MSH2) reflects the severity of OS. If increased repair enzyme production is insufficient to repair injury, cell death occurs and functional outcomes are impacted. We ...
TY - JOUR. T1 - Endothelin receptor blockade during hypothermic perfusion preservation mitigates the adverse effect of preretrieval warm ischemic injury on posttransplant glomerular filtration rate. AU - Inman, Sharon R.. AU - Burns, Thomas E.. AU - Plott, Wanda K.. AU - Pomilee, Ray A.. AU - Antonelli, Jodi A.. AU - Lewis, Richard M.. PY - 2002/7/27. Y1 - 2002/7/27. N2 - Background. Preretrieval warm ischemic injury predisposes to both short-term and long-term dysfunction of cadaveric renal allografts. We previously reported that the excretion of the vasoactive peptide, endothelin (ET), is significantly increased during hypothermic perfusion preservation (HPP) of kidneys subjected to preretrieval warm ischemia compared with nonischemic controls. As such, the purpose of this study was to determine if endothelin receptor (ET-R) blockade during HPP would improve glomerular filtration rate (GFR) of kidneys subjected to preretrieval warm ischemia when measured in situ at 2 weeks after ...
The main objective of the global In Vitro Organ Preservation market report published by OrbisPharmaReports is to identify the positioning of top players in the In Vitro Organ Preservation market along with their company profiles. A statistical analysis comparing the top players and potential for new entrants including mergers and efforts taken to adopt AI, digitization and automation are explained in the In Vitro Organ Preservation market report. The report enlists the top players along with their market revenues. Data in the In Vitro Organ Preservation report is provided through graphs, pie charts and figures for better understanding of the customers. The In Vitro Organ Preservation report also includes trends and expected opportunities widening the global In Vitro Organ Preservation market. Request a sample of In Vitro Organ Preservation Market report @ https://www.orbispharmareports.com/sample-request/70788. The In Vitro Organ Preservation report documented by OrbisPharmaReports implies an ...
TY - JOUR. T1 - Hypothermic machine preservation in liver transplantation revisited. T2 - Concepts and criteria in the new millennium. AU - van der Plaats, A. AU - tHart, NA. AU - Verkerke, GJ. AU - Leuvenink, HGD. AU - Ploeg, RJ. AU - Rakhorst, G. PY - 2004/4. Y1 - 2004/4. N2 - To overcome the present shortage of liver donors by expansion of the existing donor pool and possibly lengthening of the storage time, hypothermic machine perfusion of the liver as a dynamic preservation method is revisited. The three most important aspects are defined to be the type of preservation solution, the characteristics of perfusion dynamics, and the oxygen supply. Reviewing hypothermic liver machine perfusion experiments, the University of Wisconsin machine preservation solution is the solution most used. It is also found that nothing conclusive can be said about the optimal perfusion characteristics, since either perfusion pressure or perfusion flow is reported. The best estimation is perfusion of the liver ...
Static cold storage is currently the most used method of organ preservation worldwide. However, cutting edge technology and dramatic changes in the donor pattern have lat..
Maintaining islet viability after pancreas procurement is critical for optimal graft function and survival in islet transplantation. It is recently reported that islet yield and function were significantly higher for pancreas preserved in the modified solution added with trypsin inhibitor (ulinastatin). In this study, the FDA-cleared LifePort ® platform was applied for porcine pancreas preservation, which provided a pulsatile circulation of a perfusate with KPS1 solution added with ulinastatin (100×103 U/L) during preservation. In the control group, pancreas was preserved by traditional cold storage. After 24 hours, the pancreas was distended by intraductal collagenase NB injection and normothermically digested. The isolated islets were purified by a continuous density-gradient centrifugation. The islet yield, islet viability, stimulation index and postpreservation edema were compared between the ulinastatin group (n=7) and control group (n=8). There was difference of islet yield (IEQ/g of ...
2017 The Authors. Background: Extended criteria donor lungs deemed unsuitable for immediate transplantation can be reconditioned using ex vivo lung perfusion (EVLP). Objective identification of which donor lungs can be successfully reconditioned and will function well post-operatively has not been established. This study assessed the predictive value of markers of inflammation and tissue injury in donor lungs undergoing EVLP as part of the DEVELOP-UK study. Methods: Longitudinal samples of perfusate, bronchoalveolar lavage, and tissue from 42 human donor lungs undergoing clinical EVLP assessments were analyzed for markers of inflammation and tissue injury. Levels were compared according to EVLP success and post-transplant outcomes. Neutrophil adhesion to human pulmonary microvascular endothelial cells (HPMECs) conditioned with perfusates from EVLP assessments was investigated on a microfluidic platform. Results: The most effective markers to differentiate between in-hospital survival and ...
Ex vivo lung perfusion (EVLP) is an emerging technique for the re-conditioning of damaged donor lungs prior to transplantation. Previous work has demonstrated improvement in gas exchange in lungs subjected to this technique; however, the effect of EVLP on inflammation has not yet been examined. We hypothesised that a potential benefit of EVLP in re-conditioning donor lungs may be due to modification of the inflammatory profile.. ...
DESCRIPTION (provided by applicant): The long term goal of this project is to increase the number of Donation after Cardiac Death (DCD) livers available for transplantation by developing a new hypothermic machine perfusion (HMP) solution for recovery and preservation. Currently DCD livers are transplantable and have the potential to increase the donor pool 20-40%. However, they are largely under utilized due to poor preservation by the current method of simple cold storage (SCS). Studies show that HMP can improve graft survival in animal models. However, as warm ischemic time is increased, preliminary studies show that the current HMP solution is not sufficient to address the increase stresses of extended warm ischemia. A new solution has been developed to address depletion of energy substrates, increased membrane instability, increased oxidation damage, and microcirculation disruption. Preliminary studies suggest that this new HMP solution has potential to recover and preserve extended warm ...
To overcome the present shortage of liver donors by expansion of the existing donor pool and possibly lengthening of the storage time, hypothermic machine perfusion of the liver as a dynamic preservation method is revisited. The three most important aspects are defined to be the type of preservation solution, the characteristics of perfusion dynamics, and the oxygen supply. Reviewing hypothermic liver machine perfusion experiments, the University of Wisconsin machine preservation solution is the solution most used. It is also found that nothing conclusive can be said about the optimal perfusion characteristics, since either perfusion pressure or perfusion flow is reported. The best estimation is perfusion of the liver in a physiological manner, i.e. pulsatile arterial perfusion and continuous portal venous perfusion. The applied pressures could be chosen to be somewhat lower than physiological pressures to prevent possible endothelial cell damage. Oxygen supply is necessary to achieve optimal
DUBLIN, June 27, 2017 /PRNewswire/ -- Research and Markets has announced the addition of the Perfusion System Market Analysis By Technology (Hypothermic...
In a randomized trial conducted in 9 Ontario transplant centers, 107 cadaver kidney donors were randomized so that both kidneys were preserved either by simple cold storage (CS) or by pulsatile perfusion (PP). After exclusions and losses to follow-up, there were 90 patients in the CS group and 91 in the PP group. Total preservation times were similar in the two groups (27.7 +/- 12 and 30.5 +/- 10 hr), as was the proportion of kidneys with long (greater than 36 hr) storage times (21% and 26%). Twelve-month graft survival was 70% for CS and 75% for PP (not significant, NS); patient survival was 89% for CS and 95% for PP (NS). The incidence of kidneys that never functioned was also similar in the two groups (14% vs. 15%, respectively). However, the risk of early, reversible graft dysfunction was significantly higher for CS (44%) than for PP (31%). The same effect was observed with two independent methods of assessment of graft function. The chief effect of PP on renal function was in reduction of the mean
OBJECTIVE: The objective of this review was to systematically evaluate the evidence comparing preservation fluids for liver allografts on transplant outcomes. BACKGROUND: Adequate preservation of liver allografts for transplantation is essential for successful transplant outcomes. There are several preservation fluids available that have been specifically designed for the static cold storage of livers. These fluids differ in composition and cost. METHODS: literature search was performed using MEDLINE, EMBASE, Cochrane Library, Transplant Library, and the International Clinical Trials Registry Platform. Only randomized controlled trials were included. Studies were assessed for methodological quality. Primary outcomes were the risk of early dysfunction, primary nonfunction, retransplantation, patient survival, and graft survival. Secondary outcomes were serum biochemical parameters in the first week and biliary complications. Summary effects were calculated as relative risk and relative log survival with
Organ preservation fluid is not routine cultured at most centers. However, there are several reports of candida transmission from organ preservation fluid. ¾In this single-center retrospective study, the authors describe the microbiology of organ preservation fluid samples for 331 organs. Preservation fluid was positive in more than 60% of cases although the majority of these were low risk organisms such as coagulase negative Staphylococcus. However, some important organisms were isolated including Staphylococcus aureus, Gram-negative bacilli, and Candida spp. and these appear to increase the risk of post-operative infections. It is very likely, however, that the majority of organisms isolated would be covered by perioperative antimicrobials and only unusual organisms such as multidrug resistant bacteria or fungi may be transmitted. Therefore, it still remains unclear whether preservative fluid cultures are useful to guide post-operative antimicrobial management.. ...
Continuous hypothermic pulsatile perfusion (CHPP) may offer improved early function compared with cold static perfusion (CSP) for heart-beating cadaveric donors. With an expanding pool of donors, ie, non-heart-beating donors (NHBD), we present our preliminary results with the use of CHPP compared with CSP to preserve kidney grafts retrieved from NHBD. Eighteen consecutive locally procured cadaveric kidneys from NHBD were preserved using CHPP using UW machine perfusion solution in the Life Port kidney transporter. Perfusion parameters were measured serially during pulsatile perfusion. This group was compared with 18 NHBD cadaveric kidneys preserved with CSP. No organs were lost due to faulty technique of preparation or preparation of pulsatile perfusion. Immediate renal function was observed in 13 cases (72.2%). In CSP in NHBD, we had 16 cases with delayed graft function (88.8%). These early results show that the use of pulsatile perfusion to preserve kidneys from NHBD may be associated with improved
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The DHOPE-DCD trial compared hypothermic oxygenated machine perfusion with simple cold storage for securing liver and found significant lower incidence of biliary strictures.
Nitric oxide (NO) is a novel biologic messenger with diverse effects but its role in organ transplantation remains poorly understood. Using a porphyrinic microsensor, the first direct measurements of coronary vascular and endocardial NO production were made. NO was measured directly in the effluent of preserved, heterotopically transplanted rat hearts stimulated with L-arginine and bradykinin; NO concentrations fell from 2.1 +/- 0.4 microM for freshly explanted hearts to 0.7 +/- 0.2 and 0.2 +/- 0.08 microM for hearts preserved for 19 and 38 h, respectively. NO levels were increased by SOD, suggesting a role for superoxide-mediated destruction of NO. Consistent with these data, addition of the NO donor nitroglycerin (NTG) to a balanced salt preservation solution enhanced graft survival in a time- and dose-dependent manner, with 92% of hearts supplemented with NTG surviving 12 h of preservation versus only 17% in its absence. NTG similarly enhanced preservation of hearts stored in University of ...
Cold preservation is currently the basis of organ preservation. However, prolonged duration of cold storage or preservation of marginal organs leads to inferior outcome. Primary non-function of liver occurs in 3.5-6% of patients requiring retransplantation. Many marginal organs such as severely steatotic livers and non-heart-beating donor livers are either not retrieved or discarded after retrieval due to concerns regards viability. A better method of preservation could enable utilisation of many of these organs and increase the donor pool. This thesis describes and demonstrates successful preservation of livers at body temperature using normothermic perfusion. It aims to make preservation physiological, improve outcomes following transplantation and increase the number of donor livers that can be transplanted by allowing use of more marginal livers ...
Ischemia and reperfusion lead to injury of the liver. Ischemia-reperfusion injury is inevitable in liver transplantation and trauma and, to a great extent, in liver resection. This article gives an overview of the mechanisms involved in this type of injury and summarizes protective and treatment strategies in clinical use today. Intervention is possible at different time points: during harvesting, during the period of preservation, and during implantation. Liver preconditioning and postconditioning can be applied in the transplant setting and for liver resection. Graft optimization is merely possible in the period between the harvest and the implantation. Given that there are 3 stages in which a surgeon can intervene against ischemia-reperfusion injury, we have structured the review as follows. The first section reviews the approaches using surgical interventions, such as ischemic preconditioning, as well as pharmacological applications. In the second section, static organ preservation and ...
Principal Investigator:MORISHITA Yasuo, Project Period (FY):1996 - 1998, Research Category:Grant-in-Aid for Scientific Research (B), Section:一般, Research Field:Thoracic surgery
Organ Preservation Market, Size, Outlook 2019 to 2026 Categorizes the Global Market by Type, By Application and by Region - Industry Analysis, Size, Share, Growth Opportunities, Trends, and Forecast Report
India organ preservation market was valued at X.93 Mn in 2019 and is expected to reach at USD X1.00 Mn by 2027 at a CAGR of 14.86% over forecast period 2020-2027.
A large proportion of donor lungs are discarded due to known or presumed organ dysfunction. Ex vivo lung perfusion (EVLP) has proven its value as a tool for discrimination between reversible and irreversible donor lung pathology. However, the long-term outcome after transplantation of lungs after EVLP is essentially unknown. We report short-term and midterm outcomes of recipients who received transplants of EVLP-evaluated lungs. ...
Karangwa, S., Dutkowski, P., Fontes, P., Friend, P., Guarrera, J., Markmann, J., Mergental, H., et al. (2016). Machine Perfusion of Donor Livers for Transplantation: A Proposal for Standardized Nomenclature and Reporting Guidelines.. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 16 (10), 2932-2942. https://doi.org/10.1111/ajt.13843 ...
There is an international shortage of kidneys for transplantation, and there is great interest in optimising the kidneys available, in order to ensure that kidney transplants last for as long as possible with the best long-term function. When kidneys are recovered from deceased donors they inevitably face a period of storage while they are shipped to the recipient hospital and the logistics of transplantation are put into place. It has been shown that this period of storage can be harmful to kidneys and so this study aims to test which of two commonly used storage techniques is best for kidney transplant outcome. The first technique is cold static storage in which the kidney is placed in cold preservation solution and transported in a box of ice. The second is cold pulsatile machine perfusion in which the kidney is placed on a machine that pumps preservation fluid around the kidney ...
I think I may have hit upon a good idea for preserving mushrooms over long periods of time. This in in the absence of having a proper vacuum packing capability. After the shrooms are dry, I wrap
The aims of this research were to investigate the factors that limit in vitro storage of kidneys, establish how long kidneys could be preserved when storage conditions were made optimum, and determine whether measurements of the release of - the lysosomal enzyme N-Acetyl glucosaminidase, by kidneys during storage, could be used to predict the function of the kidneys after reimplantation. Methods are needed for storing human kidneys, after removal from cadaver donors, to allow sufficient time for transport of the kidneys, tissue typing of the donors, and pre-operative preparation of the recipients. At present, reliable 24 hour storage would provide adequate time for these -procedures to be performed. In future, as tissue typing techniques become more refined, and as more potential recipients develop antibodies as a result of previous failed transplants, it is likely that fewer kidneys will be able to be matched with recipients in the locality of the donor. , It will then be necessary to store ...
Evidence-based recommendations on normothermic extracorporeal heart preservation for transplantation following donation after brainstem death
MP preservation of DCD kidneys is superior to CS in terms of reducing DGF rate post-transplant. However, primary non-function, one year graft survival, and one year patient survival were not affected by the use of MP or CS for preservation.
2NH_3(g) + 5/2O_2(g) rarr 2NO(g) + 3H_2O(g) Is this balanced? How do you know? Is this reaction a redox reaction? Could oxidation to NO_2(g) occur?
Dogs are used in Australian laboratories for toxicity testing, infection inducement, aversive stimuli behavioural testing, and more. Humane Research Australia has also exposed the use of beagles for pharmaceutical drug testing, and the use of greyhounds in brain experiments, heart surgery experiments (where heart failure is induced to test blood pump devices, blood flow devices are tested, or circulatory death is induced to test heart preservation devices for transplantation), dental surgery experiments, terminal blood donation experiments, and others ...
Last September saw the introduction of H.R. 6234 by U.S. Representative Paul Cook (R - CA), titled Private Corrado Piccoli Purple Heart Preservation Act. It sought to make…. Read More ...
Last September saw the introduction of H.R. 6234 by U.S. Representative Paul Cook (R - CA), titled Private Corrado Piccoli Purple Heart Preservation Act. It sought to make…. Read More ...
Iori Tomita: New World Transparent Specimens If youre a fish, Iori Tomita can see right through you. Or at least he can after hes worked you over in his lab. A lifelong fisherman who studied ichthyology as an undergrad, the Japanese artist uses marine life he receives from fellow fishermen to create what he calls New World Transparent Specimens-sea creatures that have been transformed into DayGlo shells of their former selves. He first saw a sample of a fish that had been turned transparent at a university lecture six years ago, and since then he has used the same preservation technique to make thousands of hypercolored cadavers, which he sells at the Tokyu Hands department store ...
NERC has a network of environmental data centres that provide a focal point for NERCs scientific data and information. These centres hold data from environmental scientists working in the UK and around the world. The data centres are responsible for maintaining environmental data and making them available to all users, not just NERC researchers but others from science, commerce, government and education as well as the general public.. It is essential that data generated through NERC supported activities are properly managed to ensure their long-term availability. The data centres are experts in the collection of scientific information, state-of-the-art data management and preservation techniques, resulting in a high quality and important national asset available to all.. The range of data held within the data centres is vast, covering all aspects of environmental science. Some centres also hold physical specimens and sample materials collected during NERCs activities, as well as material ...
I was recently informed that IPA was originally created to increase preservation time for shipping, due to malts lack there of (at least in those times...
Paragonix Technologies develops and markets organ preservation transportation devices, designed to ensure that the organ receives every possible advantage.
Family Preservation 1 Running Head: Preservation FAMILY PRESERVATION HERZING COLLEGE Family Preservation 2 Abstract The scope of my paper will address
Oxford Med-Tech, the Isis Innovation Technology Showcase 2014, highlighted the best new technology opportunities from Oxford University and our partners, including sought-after brain mapping software and pioneering organ preservation technology.
NPS Preservation Brief 7 By de Teel Patterson TillerArchitectural Historian, Technical Preservation Services What is terra-cotta?
Notes about Diversity preservation in minimal criterion coevolution through resource limitation by Brant, J. C., & Stanley, K. O. (2020)
Apparently, Wal-Mart has not or does not care. Its probably the latter. Why? Wal-Mart has plans underway to build yet another store in the Fredericksburg, VA area. Yet another? Arent there three already? See the map below. The new store planned will be 8 miles away from other Wal-Mart stores. It will be about one…
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TY - JOUR. T1 - An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK. AU - Fisher, Andrew. AU - Andreasson, Anders. AU - Chrysos, Alexandros. AU - Lally, Joanne. AU - Mamasoula, Chrysovalanto. AU - Exley, Catherine. AU - Wilkinson, Jennifer. AU - Qian, Jessica. AU - Watson, Gillian. AU - Lewington, Oli. AU - Chadwick, Thomas. AU - McColl, Elaine. AU - Pearce, Mark. AU - Mann, Kay. AU - McMeekin, Nicola. AU - Vale, Luke. AU - Tsui, Steven. AU - Yonan, Nizar. AU - Simon, Andre. AU - Marczin, Nandor. AU - Mascaro, Jorge. AU - Dark, John. PY - 2016/11/1. Y1 - 2016/11/1. N2 - Background - Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use. Objective - The objective of the Donor Ex Vivo Lung Perfusion in UK lung transplantation study was to evaluate the clinical effectiveness and cost-effectiveness of EVLP in ...
TY - JOUR. T1 - A CLUE for better assessment of donor lungs. T2 - Novel technique in clinical ex vivo lung perfusion. AU - Ayyat, Kamal S.. AU - Okamoto, Toshihiro. AU - Niikawa, Hiromichi. AU - Sakanoue, Ichiro. AU - Dugar, Siddharth. AU - Latifi, Samir Q.. AU - Lebovitz, Daniel J.. AU - Moghekar, Ajit. AU - McCurry, Kenneth R.. N1 - Publisher Copyright: © 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 2020/11. Y1 - 2020/11. N2 - BACKGROUND: The direCt Lung Ultrasound Evaluation (CLUE) technique was proven to be an accurate method for monitoring extravascular lung water in donor lungs during ex vivo lung perfusion (EVLP) in an experimental model. The aim of this study was to examine the application of CLUE in the clinical setting. METHODS: Lungs were evaluated using acellular EVLP protocol. Ultrasound images were obtained directly from the lung surface. Images were graded according to the percentage of B-lines seen on ultrasound. CLUE scores were calculated at the ...
Introduction: Increasing the usage of hearts from marginal donors and from donors after circulatory death (DCD) has the potential to expand the donor pool. Such hearts may be resuscitated when subjected to ex vivo perfusion. In addition, this may provide an opportunity for viability testing prior to transplant. We describe a novel ex vivo perfusion system designed to reanimate porcine DCD hearts. The same system was subsequently tested using a human heart from a marginal brainstem-dead donor.. Method: In the first phase of the study 23 porcine hearts were procured following circulatory death. All hearts were subjected to a period of primary warm ischemia followed by 120 minutes of hypothermic preservation. The period of hypothermic preservation was initially static cold storage (SCS); then oxygenated machine perfusion and finally a combination of static cold storage and oxygen persufflation via the coronary sinus. Ex vivo perfusion of the hearts was performed with a normothermic, oxygenated ...
A pathophysiologic study of the kidney tubule to optimize organ preservation solutions. Background. Tissue damage at the time of organ transplantation has a negative impact on the subsequent success of the procedure, both in the immediate and longer term. Hypothermia is the principal element used to prolong organ viability ex vivo, but paradoxically also induces cellular edema through inhibition of energy-dependent adenosine triphosphatases (ATPases). This induces an electrolyte imbalance that leads to fluid influx and cell swelling. It is important, therefore, that improvements are made in the preservation of ischemic organs to reduce this injury. Methods. This study has applied a novel in vitro system to model cold and warm ischemic-induced renal tubule swelling that characterizes tissue damage in ischemia/reperfusion injury. Biochemical blockade of ATPases in this system using strophanthidin modeled the effects of energy depletion and induced cell swelling. By measuring such tubule swelling ...
The research report titled Global Organ Preservation Solutions Market Professional Survey Report 2017 market size and forecast and overview on current market trends
Much attention has been focused on the drama of the surgery and the intricacies of immunological manipulation whilst little effort has been devoted to the area of donor management, despite the fact that primary graft failure is responsible for as many post transplant deaths as either infection or rejection. Optimum preservation of the donor heart has also provided a difficult challenge, such that, despite a considerable scientific effort little advance has been achieved to extend the 4 hour safe storage limit which has remained in place over the past 20 years ...
Background: Machine perfusion (MP) has been implemented either under hypothermic and anoxic conditions or under normothermia with full oxygenation using blood as perfusate. This is the first pre-clinical large animal series using MP under subnormothermic conditions with a new hemoglobin-based oxygen carrier solution in a dual pressure system for liver preservation. Methods: Two groups of 6 Landrace pigs underwent orthotopic liver transplantation after CIT=9 hours where cold static preservation (CSP) was compared to MP. The MP allografts were continuously perfused by pulsatile and continuous pressures under full oxygenation at 21°C. Both groups had extensive graft and perfusate analysis during the preservation time. The MP group had continuous gasometry of the perfusate and tissue oximetry analysis. Mitochondrial function was analyzed in both groups. All tissues were blindly analyzed through standard histology, immunohistochemistry and electronic microscopy. Results: The CSP group had a ...
Normothermic ex vivo limb perfusion is superior to subnormothermic and hypothermic preservation - A randomised, preclinical transplant study ...
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These lungs will be brought to the study transplant center to be re-assessed by the transplant team. The lungs will be physiologically assessed during ex vivo perfusion with Steen Solution. Perfusion of these lungs will be performed using Steen solution with the addition of methylprednisolone, heparin and antibiotics. With respect to the decision of lung utilization those organs with a delta pO2 (Δ pO2 = Pulmonary vein pO2 - pulmonary artery pO2) during ex vivo perfusion assessment , 350mmHg, good lung compliance, and a favorable opinion of the transplant surgeon will be considered transplantable. Lungs will be excluded for transplantation: if the Δ pO2 is less than 350mmHg or if they demonstrate ,10% deterioration in any of the following functional parameters: pulmonary vascular resistance (PVR), dynamic compliance or airway pressures. Lungs will also be excluded if they are deemed unsuitable based on the clinical judgment of the lung transplant surgeon ...
This report features 7 companies, including Dr. Franz Köhler Chemie GmbH (Germany), Lifeline Scientific, Inc. (USA), Essential Pharmaceuticals, LLC (USA), Preservation Solutions, Inc. (USA)
The objective of this study is to evaluate the safety and effectiveness of the CLES in enabling evaluation of potential donor lungs not otherwise used for transplant into subjects with end stage, survival-limiting lung disease in need of lung transplantation. This will be accomplished by evaluating subject survival at the later of 6 months or hospital discharge post-transplant ...
TY - JOUR. T1 - Recurrent hepatitis C posttransplant. T2 - Early preservation injury may predict poor outcome. AU - Watt, Kymberly D.S.. AU - Lyden, Elizabeth R.. AU - Gulizia, James M.. AU - McCashland, Timothy M.. PY - 2006/1. Y1 - 2006/1. N2 - Organ cold/warm ischemia is thought to be a risk factor for increased severity of recurrence of hepatitis C (HCV) post liver transplantation. We had noted some HCV patients with preservation injury (PI) to have particularly poor outcomes. Our goal was to determine if PI on biopsy in HCV patients is associated with earlier, more rapidly progressive recurrence or graft and patient survival. Sixty-nine patients from the University of Nebraska transplant database were included: 23 HCV patients with PI (group = 1), 23 non-HCV patients with PI (group = 2), and 23 HCV patients without PI (group = 3). Patient groups were matched for gender, age, immunosuppression, and time of transplantation for analysis. No difference in time to recurrence was noted between ...
Peruse this collection of articles focused on various food preservation techniques, including drying, canning, pickling, freezing and more.
FUJIFILM Recording Media GmbH and Caringo, Inc. announced today a joint marketing partnership to offer a complete, on-premises data management solution for multi-petabyte environments that seamlessly integrates tape-based and object storage solutions, solving challenges to securely and cost-effectively managing data. Using Caringos Swarm Intelligent Data Management solution with FUJIFILM Software-defined Tape can help organizations manage the continued and compounding growth of infrequently accessed data. To date, only the large cloud service providers have combined disk-based and tape-based object storage solutions to enable their cloud storage services, said Tony Barbagallo, Caringo CEO. The reason they have done this is to offer the optimal price, performance and access characteristics to unstructured data at massive scale. The combined solution of Caringo Swarm and FUJIFILM Software-defined Tape now delivers these benefits to any organization with a multi-Petabyte environment.. The ...
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The invention discloses methods for preserving organs in brain-dead humans or cadavers which allows additional time for the organs to remain viable such that they may be harvested for subsequent transplantation. This invention also discloses methods for preserving and/or resuscitating organs in live (nonbrain-dead) patients, allowing for additional time to stabilize the patients condition. The methods include the steps of instrumentizing (e.g., catheterizing, cannulating, injecting, etc.) the vessels or tissues around the organ, or the organ itself sought to be preserved and/or resuscitated, the body cavity, or cavities of the body, and introducing a temperature-controlled solution to preserve and/or resuscitate the organ(s). The temperature-controlled organ preservation solution includes components such as oxygen carrying agents, antioxidants, tissue damage reversing and protecting agents, carrier vehicles, diluents, nutrients, and anti-coagulating agents. A device which performs this method is also
Looking for cold ischemia time? Find out information about cold ischemia time. sequential arrangement of all events, or the interval between two events in such a sequence. The concept of time may be discussed on several different... Explanation of cold ischemia time
AIM: We compared University of Wisconsin (UW) and Celsior preservation solutions using a new model of human intestinal preservation that mimics the clinical conditions of small bowel procurement. METHODS: Intestinal grafts were harvested from four multiorgan donors. After classic warm dissection for organ procurement, an ileal segment of 50 cm was immediately flushed with Celsior. After the perfusion of the abdominal organs with UW, a second segment of adjacent ileum was harvested. The two intestinal grafts were then divided into segments by stapling, before immersion into the corresponding preservation solution (Celsior or UW) for 0-, 6-, 12-, or 24-hour incubation at 4 degrees C. A histological score was graded after blinded examination of three random specimens within each ileal graft for each duration of preservation. RESULTS: Control specimens showed normal histology. After 6 hours of preservation, most villi showed complete epithelial detachment although the crypts appeared intac
Organ transplant surgery has become the principle method to treat patients with dysfunctional organs. However, at present, the biggest hurdle to overcome is the severe shortage of available organs. To expand the supply of healthy donor organs, technological developments based on novel concepts are expected to improve organ preservation and resuscitation. In this project, we aim to develop a novel three-dimensional organ perfusion culture system that allows long-term preservation and resuscitation of severely ischemic organs in in vitro cultures. We hope to contribute to healthcare through the development of a novel technology to expand the supply of available organs.. [Integrated Collaborative Research with SCREEN Holdings Co.,Ltd.]. ...
Abstract Survival rates after cancer have increased significantly in recent decades; however, these treatments also have drawbacks, and patients (or parents in the case of children) must be informed of the long-term side effects of oncological treatments and the possible options for preserving the fertility of these patients. It is important to set out clearly…
Wagner CE, Pope NH, Charles EJ, Huerter ME, Sharma AK, Salmon MD, Carter BT, Stoler MH, Lau CL, Laubach VE, Kron IL. Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death. J Thorac Cardiovasc Surg. 2016 Feb; 151(2):538-45 ...
Food spoiling and poisoning caused by microbial contamination can cause major health, social, and economic problems. The broad scope of antimicrobial approaches to kill or prevent the growth of microorganisms in foods and ...
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Induction chemotherapy with paclitaxel and cisplatin followed by radiotherapy for larynx organ preservation in advanced laryngeal and hypopharyngeal cancer offers moderate late toxicity outcome (DeLOS-I-trial) Academic Article ...
Evidence-based recommendations on ex-situ machine perfusion for extracorporeal preservation of livers for transplantation in people of all ages
TY - JOUR. T1 - cAMP-mediated vascular protection in an orthotopic rat lung transplant model. T2 - Insights into the mechanism of action of prostaglandin E1 to improve lung preservation. AU - Naka, Yoshifumi. AU - Roy, Dilip K.. AU - Liao, Hui. AU - Chowdhury, Nepal C.. AU - Michler, Robert E.. AU - Oz, Mehmet C.. AU - Pinsky, David J.. PY - 1996/1/1. Y1 - 1996/1/1. N2 - Prostaglandin E1 (PGE1) is often added to the donor pulmonary flush solution to enhance clinical lung preservation for transplantation. Although PGE1 is thought to act as a pulmonary vasodilator during the harvest period, the precise mechanism(s) of action whereby PGE1 enhances lung preservation is unknown. Because cAMP levels decline in endothelial and vascular smooth muscle cells exposed to hypoxia, we hypothesized that a PGE1-mediated increase in cAMP levels within the preserved lungs might improve pulmonary vascular homeostasis following lung transplantation. Rat lungs demonstrated a time-dependent decline in cAMP levels ...
Located in Fayetteville, Arkansas, the National Agricultural Law Center serves the nations vast agricultural community and is a key partner of the USDA National Agricultural Library. For more information, click here. Web design and hosting by One Big Kid ...
December 3, 2017, marked the 50th anniversary of the first human-to- human heart transplant (HT) surgery, performed by Dr Christiaan Barnard at the Groote Schuur Hospital in Capetown, South Africa. Since this seminal operation, ,124 000 HTs have been performed, and the survival rate has improved significantly (current median survival: 11.9 years) as a result of refinements in donor and recipient selection, advances in surgical techniques, organ preservation strategies, and immunosuppressive therapy.. Despite improvement or normalization of left ventricular systolic function, HT recipients (HTRs) typically have a peak aerobic power (peak Vo2) that is ≈40% lower than age- and activity-matched healthy people.1 Persistent impairment of peak Vo2 following HT is multifactorial with contributions from abnormal skeletal muscle function associated with pre-HT heart failure (HF), bedrest deconditioning associated with prolonged hospitalization, posttransplant cardiac allograft denervation, and ...
Abstract: The ability to replace organs and tissues on demand could save or improve millions of lives each year globally and create public health benefits on par with curing cancer. Unmet needs for organ and tissue preservation place enormous logistical limitations on transplantation, regenerative medicine, drug discovery, and a variety of rapidly advancing areas spanning biomedicine. A growing coalition of researchers, clinicians, advocacy organizations, academic institutions, and other stakeholders has assembled to address the unmet need for preservation advances, outlining remaining challenges and identifying areas of underinvestment and untapped opportunities. Meanwhile, recent discoveries provide proofs of principle for breakthroughs in a family of research areas surrounding biopreservation. These developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation ...
Figure 4-6: Functions of the Preservation Planning Functional Entity The Monitor Designated Community function interacts with Archive Consumers and Producers to track changes in their service requirements and available product technologies. Such requirements might include data formats, media choices, preferences for software packages, new computing platforms, and mechanisms for communicating with the Archive. This function may be accomplished via surveys, via a periodic formal review process, via community workshops where feedback is solicited or by individual interactions. It provides reports, requirements alerts and emerging standards to the Develop Preservation Strategies and Standards function. It sends preservation requirements to Develop Packaging Designs. The Monitor Technology function is responsible for tracking emerging digital technologies, information standards and computing platforms (i.e., hardware and software) to identify technologies which could cause obsolescence in the ...
Cold storage wallet cryptocurrency. . Based on the storage method, we can group cryptocurrency wallets into two categories- cold wallets (which uses cold storage) and hot wallets. trading-news.site: Seedsafe Cryptocurrency Seed Storage Safe - Cold Storage Wallet Backup - Compatible with Ledger, Trezor, KeepKey Hardware Wallets, Cold.. future of ltc cryptocurrency.
WATERS IGL® Pulsatile Perfusion Solution has a calculated potassium concentration of 25 mEq/L, a sodium concentration of 100 mEq/L, an osmolarity of 300 mOsM, and a pH of 7.4 at room temperature. Its ion composition is comparable with that of the intracellular milieu. ...
Current Research and Scholarly Interests Methods of evaluation of biopsies; differentiation and, classification of neoplasms; immunohistochemistry; scanning and, transmission electron microscopy; cardiovascular pathology;, histologic assessment of bone biopsies; heart preservation and, restoration; myocardial biopsies; venous autograft coronary artery, bypass; cardial and heart valve transplantation. ...
The Ice Commander is intended for ice and still/static cold water rescues only by trained professionals with the required and approved operating standards
It has been proven scientifically that beef jerky can help you build strong muscles. Beef jerky refers to strips of dried beef that are mostly consumed as snacks. High in proteins and low in fat content, beef jerky is a favorite among athletes and body-builders. If building lithe muscles is your objective, then beef jerky is a part of every shopping list you create.. Beef jerky started out as a means of increasing the preservation period of meat during an era when refrigerators were not yet available to hunters. The beneficial effects of dried beef did not go unnoticed, and nutritionists lost no time in identifying what makes beef jerky the health food that it is.. Beef jerky is important for body builders as it is packed with proteins and iron, but is low on fat. The preparation of beef jerky is a process that sucks out moisture and fats. An ounce of beef jerky contains about 15g of protein, almost twice the amount of the mineral in pork. Vitamins, or amino acids, are the building blocks of ...
The latest edition of the clinical practice guideline on larynx preservation strategies for the treatment of laryngeal cancer from the American Society of Clini
Biostasis Organ transplant Southard JH, Belzer FO (1995). "Organ preservation". Annu Rev Med. 46 (1): 235-47. doi:10.1146/ ... University of Wisconsin cold storage solution remains what is often called the gold standard for organ preservation, despite ... UW solution was the first solution designed for use in organ transplantation, and became the first intracellular-like ... Developed in the late 1980s by Folkert Belzer and James Southard for pancreas preservation, the solution soon displaced ...
Speech organ • Squamous odontogenic tumor • Stafne defect • Stan Brown • Stanley D. Tylman • Stanley McInnis • Stannous ... Socket preservation • Sodium alginate • Soft palate • SoftDent • SOHP • Sonicare • Southern Regional Testing Agency • Sozodont ... Enamel organ • Enamel pearl • Enamel rod • Enamel spindles • Enamel tufts • Enamelin • Endodontic therapy • Endodontics • ...
In addition, the organ's pipe chambers were effectively sealed off from the auditorium by the new shell - rendering the organ ... Cleveland Landmark Wins National Preservation Award. National Trust for Historic Preservation. 2001-10-01. Rosenberg, Donald. ... The stage included a place for the relocation of the Orchestra's newly-restored Ernest M. Skinner organ. The project also ... Finally, the 6,025-pipe Ernest M. Skinner organ could be heard, but its positioning outside the auditorium itself was ...
Southard JH (June 1989). "Viability assays in organ preservation". Cryobiology. 26 (3): 232-8. doi:10.1016/0011-2240(89)90017-5 ... For transplantable whole organs, the ultimate assay is the ability to sustain life after transplantation, an assay which is not ... A viability assay is an assay that is created to determine the ability of organs, cells or tissues to maintain or recover a ... Pegg, D. E. (1989-06-01). "Viability assays for preserved cells, tissues, and organs". Cryobiology. 26 (3): 212-231. doi: ...
"The use of electron microscopy in renal preservation and perfusion." In: Norman JC, ed. Organ perfusion and preservation. New ... Manax, William G. (1965-05-31). "Hypothermia and Hyperbaria: Simple Method for Whole Organ Preservation". JAMA. 192 (9): 755-9 ... Machine perfusion (MP) is a technique used in organ transplantation as a means of preserving the organs which are to be ... "Preservation of Organs for Transplantation Evidence of Detrimental Effect of Rapid Cooling". European Surgical Research. 5 (5 ...
... extensive preservation needs; and a main organ in disrepair. Repointing the building was estimated to cost at least $5 million ... The organ was to be replaced with a new instrument built by Dobson Pipe Organ Builders, but this plan was scrapped in 2009. As ... The Great Organ was installed by the Ernest M. Skinner & Son Organ Company in 1938. The original instrument consisted of ... "Washington National Cathedral : Organ Project". Archived from the original on November 30, 2009. Retrieved December 16, 2018. " ...
In 2003, the church commissioned a new pipe organ from American-based John-Paul Buzard Pipe Organ Builders, the Opus 29. In ... "All Saints' Episcopal Church". Atlanta Preservation Center. Retrieved May 13, 2020. "All Saints' Episcopal Church". American ... "Buzard Opus 29 Atlanta, Georgia". John-Paul Buzard Pipe Organ Builders. May 25, 2015. Retrieved May 13, 2020. Brett 2020. ...
ISBN 978-0-415-24700-9. Fahy, G.M.; Hirsh, A. (1982). Prospects for Organ Preservation by Vitrification. In: Organ Preservation ... and organ cryopreservation. In: Principles & Practice of Fertility Preservation (Donnez, J., and Kim, S.S., Eds.). Cambridge ... Before joining Twenty-First Century Medicine, he was the chief scientist for Organ, Inc and of LRT, Inc. He was also Head of ... Fahy GM, Wowk B, Wu J, Phan J, Rasch C, Chang A, Zendejas E (2004). "Cryopreservation of organs by vitrification: perspectives ...
6. Hesse U.J., et al.: Organ preservation with HTK and UW solution. Pabst Sci. Publishers, D-49525 Lengerich, 1999. 7. Hatano E ... 4. Pokorny H., et al.: Histidine-tryptophan-ketoglutarate solution for organ preservation in human liver transplantation - a ... Specific Pokorny H; Rasoul-Rockenschaub S; Langer F (2004). "Histidine-tryptophan-ketoglutarate solution for organ preservation ... low-potassium preservation solution used for organ transplantation. The solution was initially developed by Hans-Jürgen ...
"New 'supercooling' technology increases organ preservation time". The Times of India. 30 June 2014. Retrieved 30 June 2014. ... "Whole organ 'grown' in world first". BBC. 24 August 2014. Retrieved 25 August 2014. Agle, DC; Brown, Dwayne; Bauer, Markus (25 ... This breakthrough is a major step toward being able to grow whole organs from stem cells. 6 April - Samsung has developed a new ... related image) Experiments on rat livers have shown that a new cooling method can triple the time that donor organs can be ...
The original Barton Organ is still used for special presentations. In 1964, the theatre underwent drastic modernization. Due to ... Recent preservation efforts have helped to restore the original splendor of the State. After years of uncertainty, Kalamazoo's ... Theatre organs were a unique combination of multiple instruments and sound effects. These intriguing machines greatly varied in ... The smaller palaces, such as the Kalamazoo State Theatre, would have had a chamber group or pipe organ. This was a great ...
"National Organ Transplant Act" (PDF). 1984-10-19. Retrieved 2016-08-23. "United Network for Organ Sharing" (PDF). Retrieved ... The Methodist program implemented the first donor blood cryo-preservation allowing the rapid cross matching of pairs in a swap ... "United Network for Organ Sharing" (PDF). Retrieved 2016-08-26. Flechner, S. M.; Leeser, D.; Pelletier, R.; Morgievich, M.; ... "Organ Procurement and Transplantation Network and Scientific Registry of Transplant Recipients 2010 Data Report". American ...
Perdrizet, George (1989). "Stress conditioning: a novel approach to organ preservation". "Europe PMC". 46 (1). pp. 23-6. PMID ... More recently, stress conditioning is being studied as a potential solution for the preservation of coral reefs as they are ... The science is clear that climate change will drive many species extinct, and a traditional, land-preservation ethic will not ... Increased resistance to warmer living conditions allow for the preservation of the Great Barrier Reef even as water ...
CS1 maint: discouraged parameter (link) Perdrizet, George (1989). "Stress conditioning: a novel approach to organ preservation ... More recently, stress conditioning is being studied as a potential solution for the preservation of coral reefs as they are ... Increased resistance to warmer living conditions allow for the preservation of the Great Barrier Reef even as water ...
2008). 'Metabolic Management - Organ Procurement and Preservation For Transplantation. New York: Landes Bioscience Springer. ... When it affects many cells in an organ, it causes some pallor, increased turgor, and increase in weight of the organ. On ... The body can make more cells to replace the damaged cells keeping the organ or tissue intact and fully functional. When a cell ... Stromal cells are the cells that support the parenchymal cells in any organ. Fibroblasts, immune cells, pericytes, and ...
New it is a provincial cultural relic preservation organ. The town is crossed by Provincial Highway S222. A Huaicong 2008, p. ...
The Organ Preservation Alliance[1] is also headquartered there; the Alliance is a nonprofit organization that works in ... "to catalyze breakthroughs on the remaining obstacles towards the long-term storage of organs" to overcome the drastic unmet ... medical need for viable organs for transplantation. Kleenspeed Technologies is headquartered there. On September 28, 2005, ... partnership with the Methuselah Foundation's New Organ Prize " ...
"The Statler Organ". The Theatre Organ Home Page. Retrieved May 18, 2020. CS1 maint: discouraged parameter (link) Willig, Max ( ... Buffalo Landmark & Preservation Board (August 1, 1979). "Building-Structure Inventory Form: St. Boniface Roman Catholic Church ... John the Evangelist RC Church Complex" (PDF). New York State Office of Parks, Recreation and Historic Preservation. Retrieved ... Mark's Roman Catholic Church" (PDF). New York State Office of Parks, Recreation and Historic Preservation. Retrieved June 8, ...
Artificial organs Anderson, Richard A.; Wallace, W. Hamish B.; Telfer, Evelyn E. (2017). "Ovarian tissue cryopreservation for ... An artificial ovary is a potential fertility preservation treatment that aims to mimic the function of the natural ovary. ... Cho, Eun; Kim, Yoon Young; Noh, Kevin; Ku, Seung-Yup (August 2019). "A new possibility in fertility preservation: The ... Conventional fertility preservation for females involves oocyte cryopreservation or ovarian tissue cryopreservation. However, ...
The fund donated $2 million to the Organ Preservation Alliance. The fund has also donated $1 million or more to organizations ... "The Pineapple Fund Donates Millions to the Organ Preservation Alliance and Methuselah Foundation". Fight Aging!. 2021-03-29. ...
"Subzero organ preservation: the dawn of a new ice age?". Current Opinion in Organ Transplantation. 22 (3): 281-286. doi:10.1097 ... The freezers have attracted attention among organ banking and transplantation surgeons, as well as the food processing industry ... Szabó, Gábor (15 September 2012). "Hearts From the Deep Freezer? Novel Concept to Increase Safe Cardiac Preservation Times". ... "Supercooling enables long-term transplantation survival following 4 days of liver preservation". Nature Medicine. 20 (7): 790- ...
Vincent". New York State Office of Parks, Recreation and Historic Preservation. Retrieved 2011-01-12. CS1 maint: discouraged ... NYC Organ Project. ...
"Trends in Total Laryngectomy in the Era of Organ Preservation". Otolaryngology-Head and Neck Surgery. 147 (1): 85-90. doi: ... Total laryngectomy results in the removal of the larynx, an organ essential for natural sound production. The loss of voice and ...
The church houses a fully functional 1904 Bates & Culley pipe organ. "National Register Information System". National Register ... Historic Preservation Office. March 1, 2011. p. 13. Archived from the original (PDF) on June 4, 2011. Retrieved April 26, 2011 ... CS1 maint: discouraged parameter (link) "Holy Trinity Spring Lake - Organ". Retrieved 2010-05-23. CS1 maint: discouraged ...
Development of multiple technical advances in organ preservation, procurement and transplant; Delineating the indications and ... Organ donation Xenotransplantation Immunosuppressive drugs Organ transplant Transplant rejection Cronin, Mike (2010-01-29). " ... Milestones in Organ Transplantation National Kidney Foundation Starzl TE, Klintmalm GB, Porter KA, Iwatsuki S, Schröter GP ( ... Thomas Earl Starzl (March 11, 1926 - March 4, 2017) was an American physician, researcher, and expert on organ transplants. He ...
Cryo-preservation or cryo-conservation is a process where organelles, cells, tissues, extracellular matrix, organs, or any ... Gaseous oxygen perfusion/persufflation can enhance organ preservation relative to static cold storage or hypothermic machine ... as a method of organ preservation". Cryobiology. 64 (3): 125-43. doi:10.1016/j.cryobiol.2012.01.007. PMC 3519283. PMID 22301419 ... Blood can be replaced with inert noble gases and/or metabolically vital gases like oxygen, so that organs can cool more quickly ...
... particularly to renal transplant surgery and organ preservation, to accreditation and professional standards, as an academic, ... Kenneth Ralph Ames - For service to the preservation of rail transport history, and to youth. Jack Anastas - For service to the ... Pastor Perez De Lasala - For service to pipe organ restoration. Jaimie De Salis - For service to community health. Janeth ... Ian Trevor McIvor - For service to military history preservation, and to the community. Shirley Naina McIvor - For service to ...
Hillier, P. S. G. (1 February 2012). "Modern methods of fertility preservation: a tribute to Roger Gosden". Molecular Human ... "XVth Development and Function of Reproductive Organs International Conference". University of St Andrews. Archived from the ... "Board Of Directors". International Society for Fertility Preservation. Archived from the original on 6 February 2017. Retrieved ... Silber, S. J. (1 February 2012). "Ovary cryopreservation and transplantation for fertility preservation". Molecular Human ...
The excretory organs of barnacles are maxillary glands.[citation needed] The main sense of barnacles appears to be touch, with ... their poor skeletal preservation is due to their restriction to high-energy environments, which tend to be erosional - ...
World Health Organ. 91 (4): 277-282. doi:10.2471/BLT.12.110015. PMC 3629451. PMID 23599551.. ... Folk medicine consists of the healing practices and ideas of body physiology and health preservation known to some in a culture ... These include trauma centers, burn treatment centers, advanced neonatology unit services, organ transplants, high-risk ... The anesthesiologist's role during surgery is to prevent derangement in the vital organs' (i.e. brain, heart, kidneys) ...
"Polonium 210 in tobacco, cigarette smoke, and selected human organs". Public Health Reports. 81 (2): 121-7. doi:10.2307/ ... Penal Code and also the definition of air pollution as contained in the statutes dealing with the protection and preservation ... Penal Code and within the definition of air pollution as contained in the statutes dealing with protection and preservation of ...
Renal transplantation replaces kidney function by inserting into the body a healthier kidney from an organ donor and inducing ... the preservation of kidney health, and the treatment of kidney disease, from diet and medication to renal replacement therapy ( ... Many diseases affecting the kidney are systemic disorders not limited to the organ itself, and may require special treatment. ... treatment for end-stage kidney failure although its worldwide availability is limited by lack of availability of donor organs. ...
Organ printing. *Personalized medicine. *Regenerative medicine *Stem-cell therapy. *Tissue engineering. *Robot-assisted surgery ...
This campaign led to the formation of the Stroud Preservation Trust. which has been instrumental in saving many of the town's ... A reference to a 1798 Poem mocking Stroud residents for opening a church organ "before it could speak".[14] "Gotham" was a ...
"Fibroblast precursors in normal and irradiated mouse hematopoietic organs". Experimental Hematology 4 (5): 267-74. 1976. PMID ... European Biotech Company Biocell Center Opens First U.S. Facility for Preservation of Amniotic Stem Cells in Medford, ... Stem Cells Tapped to Replenish Organs thescientist.com, Nov 2000. By Douglas Steinberg ... Steinberg, Douglas (November 2000) Stem Cells Tapped to Replenish Organs thescientist.com ...
This problem has been addressed in California by the Ridley-Tree Condor Preservation Act, a bill that went into effect July 1, ... which use their feet as weapons or organs of prehension. ... with the implementation of the Ridley-Tree Condor Preservation ...
Darwin C. (1859). On the origin of species by means of natural selection, or the preservation of favoured races in the struggle ... Istenič L. & Bulog B.(1984). Some evidence for the ampullary organs in the European cave salamander Proteus anguinus (Urodela, ... Tudi pinealni organ človeške ribice ima pokrnele fotoreceptorne celice in vsebujejo vidni pigment kot pokrnele celice v ...
... the genital organs (because they produce emissions), as well as the rest of the lower body. Clothes for the lower body, as well ... Islam is the religion that these communities align themselves with and the people are recognized for their staunch preservation ...
Be it remembered, however, that Verdi's melodies were once dismissed as barrel-organ fodder. The truth is that music that ... Puccini cylinder recordings, from the Cylinder Preservation and Digitization Project at the University of California, Santa ...
... different environments are more favorable to the preservation of different types of organism or parts of organisms.[29] Further ... "Exceptional Fossil Preservation and the Cambrian Explosion". Integrative and Comparative Biology. 43 (1): 166-177. doi:10.1093 ...
... more organ preservation and fewer side effects.[84] While access to radiotherapy is improving globally, more than half of ... In afterloading a hollow tube or applicator is placed surgically in the organ to be treated, and the sources are loaded into ... To spare normal tissues (such as skin or organs which radiation must pass through to treat the tumor), shaped radiation beams ... Biegala M, Hydzik A (2016). "Analysis of dose distribution in organs at risk in patients with prostate cancer treated with the ...
"Reconciliation through Preservation: Celebrating Restoration of Unique Part of Cyprus' Cultural Heritage". US Embassy in Cyprus ... Zakon o začasnih določbah turških občinskih odborov iz leta 1959 je ustanovil občinski organ, ki ga vodi »turški občinski odbor ... Organ vasi Ortakeuy je bil podobno opredeljen kot soseska turške občine Nikozija. ... opredeljen kot »organ oseb, ki so jih prvi dan julija 1958 ustanovili turški prebivalci v mestih Nikozija, Limassol, Famagusta ...
"Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys". Exp ...
How and why we evolved our particular taste and flavor sense organs and our general food likes and dislikes ... There are many branches of food science that study different aspects of food, such as safety, microbiology, preservation, ... this book is to give an understanding of the chemical principles upon which good practices in food preparation and preservation ...
"World Allergy Organ J. 4 (2): 13-37. doi:10.1097/WOX.0b013e318211496c. ISSN 1939-4551. PMC 3500036. PMID 23268454.. ... "World Allergy Organ J. 7 (1): 1-14. doi:10.1186/1939-4551-7-10. PMC 4005619. PMID 24791183.. ... multiple-organ autoimmune disorder primarily affecting the small intestine.[55][56][57] ... improving circulation to body organs. Epinephrine is available by prescription in an autoinjector.[66] ...
The fermentation of dairy foods represents one of the oldest techniques for food preservation.[citation needed] ... a risk exists for the passage of viable bacteria from the gastrointestinal tract to the internal organs (bacterial ...
by organ. Barks. *General : Tanbark. *Acacias (most notably Acacia pycnantha and Acacia decurrens) ...
... spread to the eye from another organ). The two most common cancers that spread to the eye from another organ are breast cancer ... Ocular oncology takes into consideration that the primary requirement for patients is preservation of life by removal of the ... tumor, along with best efforts directed at preservation of useful vision, followed by cosmetic appearance. The treatment of ...
... (DOA), also dead in the field and brought in dead (BID), indicates that a patient was found to be already clinically dead upon the arrival of professional medical assistance, often in the form of first responders such as emergency medical technicians, paramedics, or police. In some jurisdictions, first responders must consult verbally with a physician before officially pronouncing a patient deceased, but once cardiopulmonary resuscitation is initiated, it must be continued until a physician can pronounce the patient dead. Dead on arrival can also mean that a person is said by a doctor to be dead upon their arrival at a hospital, emergency room, clinic, or ward. A person can be pronounced dead on arrival if cardiopulmonary resuscitation or mouth to mouth resuscitation is found to be futile. ...
Aggressive Berger's disease (a rarer form of the disease) can attack other major organs, such as the liver, skin and heart. ... for the initial 3 months followed by azathioprine for a minimum of 2 years resulted in a significant preservation of renal ... ranging from a benign recurrent hematuria up to a rapid progression to chronic kidney failure and failure of other major organs ...
Eventually, the tumor may grow large enough to invade nearby organs such as the seminal vesicles or the rectum, or the tumor ... Walsh PC, Lepor H, Eggleston JC (1983). "Radical prostatectomy with preservation of sexual function: anatomical and ... This invasion of other organs is called metastasis. Prostate cancer most commonly metastasizes to the bones, lymph nodes, and ... The prostate is a zinc-accumulating, citrate-producing organ. The protein ZIP1 is responsible for the active transport of zinc ...
... can halt the bloodflow to vital organs, leading to paralysis or even death.[1] Alongside such techniques students learn an ... Sri Lanka's Ministry of Culture and the Arts has also taken action to support the survival and preservation of angampora:[8] ...
The tribute set included Gillian Welch, Dave Rawlings, Willie Watson, the New Orleans Preservation Hall Jazz Band, Jason Isbell ... Mike Bloomfield on lead guitar and Al Kooper on organ. Two of Bloomfield's bandmates from the Paul Butterfield Blues Band, ...
The digestive organs, brain, and lungs are the first to disintegrate. Under normal conditions, the organs are unidentifiable ... The main objectives of this form of preservation are to keep the body from decomposing, help the tissues retain their color and ... For a cadaver to be viable and ideal for anatomical study and dissection, the body must be refrigerated or the preservation ... Modern embalming for anatomical purposes no longer includes evisceration, as this disrupts the organs in ways that would be ...
Wings, legs, and fins: How do new organs arise in evolution? Neil Shubin, University of Chicago. "Primordial Fish Had ... doi:10.1007/s12052-009-0135-2. Martill D.M. (1993). "Soupy Substrates: A Medium for the Exceptional Preservation of ...
Since the flowers are the reproductive organs of plant, they mediate the joining of the sperm, contained within pollen, to the ... It can represent a taxon, usually giving ranges of the numbers of different organs, or particular species. Floral formulae have ... The molecular control of floral organ identity determination appears to be fairly well understood in some species. In a simple ... Male and female reproductive organs are generally found in separate flowers, the male flowers having a number of long filaments ...
... as it can cause severe ischemia to major organs.[1][25] Terlipressin is a vasopressin analogue that has been found in one large ... does not lead to recuperation or preservation of kidney function in patients with HRS, and is essentially only used to avoid ...
Red biotechnology is the use of biotechnology in the medical and pharmaceutical industries, and health preservation.[24] This ... branch involves the production of vaccines and antibiotics, regenerative therapies, creation of artificial organs and new ...
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FOPS Members LoginFOPS Members Organ InsuranceOrgan Owners GuidelinesFOPS Membership InformationFOPS Membership ProspectusFOPS ... Organ Building and Technical Discuss your organ building and technical issues here ... Other Organs Discussion about Theatre/Cinema/Church or other types of organs ...
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The organ (a Dean) was built, according to a bit of research, in 1982. I am not an organ builder, but I felt that as I was the ... organ_repair_7.jpg [ 31.68 KiB , Viewed 21892 times ] And after all that the organ is playing very well and I now know a lot ... organ_repair_3.jpg [ 43.09 KiB , Viewed 21892 times ] Then I gave the board to organ repairer Sid Reeves for re-leathering, who ... FOPS Members LoginFOPS Members Organ InsuranceOrgan Owners GuidelinesFOPS Membership InformationFOPS Membership ProspectusFOPS ...
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  • I operate the ex-Stuart Marti-Bowler 31 keyless Dean organ that now belongs to George Houghton. (fops.org)
  • And after all that the organ is playing very well and I now know a lot more about the mechanics of a keyless system! (fops.org)
  • This should be a doddle on a keyless organ. (fops.org)
  • Maybe you can start a new trend for organ builders! (fops.org)
  • I am also hoping to fit a midi system to this organ to increase its versatility. (fops.org)
  • Software and arranging for MIDI organs. (fops.org)
  • If anyone is interested in arranging music for MIDI organs. (fops.org)
  • Welcome to the Organ Building and Technical section of the FOPS Forum. (fops.org)
  • One of the basis principles of using frequency as a transformative and healing modality is to understand the idea that part of the body is in a state of vibration : every organ, every bone, every tissue, every system. (neeeeext.com)
  • Anything about organs and mechanical music, etc. (fops.org)
  • A: The Fair Organ Preservation Society (FOPS) are taking advantage of the fact that an increasing number of members are using the Internet and have decided to utilise the payment facilities provided by PayPal to allow members to renew their membership subscription of the FOPS online. (fops.org)
  • Organ Repair. (fops.org)
  • I will 'get the ball rolling' with an item about an organ repair I carried out recently. (fops.org)
  • I look forward to hearing the Organ after the repair Dave.now that all the notes are playing again. (fops.org)
  • The Preservation Fund was created in 1986 to provide funds exclusively for the ongoing preservation, maintenance, restoration and repair of the Cathedral property and grounds. (jaxcathedral.org)
  • Then I gave the board to organ repairer Sid Reeves for re-leathering, who made it look like new! (fops.org)
  • To assure a sacred space of God's grace for future generations, gifts can be made to the Preservation Fund. (jaxcathedral.org)
  • Hi, I have just acquired a 48 note Chiappa organ which is playing quite well but probably needs the trumpets tuned slightly. (fops.org)
  • Each of these programs are designed to progressively (sorry to use the P word - Glenn Beck) eliminate toxins stored within the body as well as nourish, strengthen and tone the organs. (thesurvivalpodcast.com)
  • Besides a love of organs, i have always done models but so have most of the readers on this forum. (fops.org)