AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Tissue and Organ ProcurementTissue DonorsBrain DeathOrgan TransplantationPresumed ConsentTissue and Organ HarvestingCadaverDonor SelectionWaiting ListsTissue BanksLiving DonorsDeathLiver TransplantationKidney TransplantationDirected Tissue DonationOrgan PreservationTransplantationUnited States Health Resources and Services AdministrationGraft SurvivalPrinciple-Based EthicsTransplantsFacility Regulation and ControlInformed ConsentUnited StatesHealth Care RationingHeart TransplantationValue-Based PurchasingEnd Stage Liver DiseaseFamilyEthics, MedicalRetrospective StudiesLiver FailureBlood DonorsTime FactorsRegistriesGraft RejectionTransplantation, HomologousPatient SelectionSculptureTreatment OutcomeOrgan SpecificityThird-Party ConsentAltruismDrugs, EssentialInsurance, LifeDelayed Graft FunctionOrgan Preservation SolutionsPosthumous ConceptionMedicareLung TransplantationLiver DiseasesLiverRisk AssessmentDisease Transmission, InfectiousPurchasing, HospitalTissue DistributionTissue PreservationMultiple Organ FailureMolecular Sequence DataTissue KallikreinsBlood-Borne PathogensFacial TransplantationOrgan SizeMoralsDissectionOrgan of CortiDecision MakingPancreasPancreas TransplantationFatal OutcomeDeltaretrovirus InfectionsProportional Hazards ModelsImmunohistochemistryKidneyBase SequenceAmino Acid SequenceCold IschemiaRabies virusCommission on Professional and Hospital ActivitiesFinancial ManagementRNA, Messenger
Tissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Brain Death: A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Presumed Consent: An institutional policy of granting authority to health personnel to perform procedures on patients or to remove organs from cadavers for transplantation unless an objection is registered by family members or by the patient prior to death. This also includes emergency care of minors without prior parental consent.Tissue and Organ Harvesting: The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.Cadaver: A dead body, usually a human body.Donor Selection: The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.Waiting Lists: Prospective patient listings for appointments or treatments.Tissue Banks: Centers for acquiring, characterizing, and storing organs or tissue for future use.Living Donors: Non-cadaveric providers of organs for transplant to related or non-related recipients.Death: Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Kidney Transplantation: The transference of a kidney from one human or animal to another.Directed Tissue Donation: Tissue, organ, or gamete donation intended for a designated recipient.Organ Preservation: The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Transplantation: Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.United States Health Resources and Services Administration: A component of the PUBLIC HEALTH SERVICE that provides leadership related to the delivery of health services and the requirements for and distribution of health resources, including manpower training.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Principle-Based Ethics: An approach to ethics that focuses on theories of the importance of general principles such as respect for autonomy, beneficence/nonmaleficence, and justice.Transplants: Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.Facility Regulation and Control: Formal voluntary or governmental procedures and standards required of hospitals and health or other facilities to improve operating efficiency, and for the protection of the consumer.Informed Consent: Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.United StatesHealth Care Rationing: Planning for the equitable allocation, apportionment, or distribution of available health resources.Heart Transplantation: The transference of a heart from one human or animal to another.Value-Based Purchasing: Purchasers are provided information on the quality of health care, including patient outcomes and health status, with data on the dollar outlays going towards health. The focus is on managing the use of the health care system to reduce inappropriate care and to identify and reward the best-performing providers. (from http://www.ahrq.gov/qual/meyerrpt.htm accessed 11/25/2011)End Stage Liver Disease: Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.Family: A social group consisting of parents or parent substitutes and children.Ethics, Medical: The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)Blood DonorsTime Factors: Elements of limited time intervals, contributing to particular results or situations.Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Patient Selection: Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.SculptureTreatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Organ Specificity: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.Third-Party Consent: Informed consent given by someone other than the patient or research subject.Altruism: Consideration and concern for others, as opposed to self-love or egoism, which can be a motivating influence.Drugs, Essential: Drugs considered essential to meet the health needs of a population as well as to control drug costs.Insurance, Life: Insurance providing for payment of a stipulated sum to a designated beneficiary upon death of the insured.Delayed Graft Function: General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.Organ Preservation Solutions: Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.Posthumous Conception: Conception after the death of the male or female biological parent through techniques such as the use of gametes that have been stored during his or her lifetime or that were collected immediately after his or her death.Medicare: Federal program, created by Public Law 89-97, Title XVIII-Health Insurance for the Aged, a 1965 amendment to the Social Security Act, that provides health insurance benefits to persons over the age of 65 and others eligible for Social Security benefits. It consists of two separate but coordinated programs: hospital insurance (MEDICARE PART A) and supplementary medical insurance (MEDICARE PART B). (Hospital Administration Terminology, AHA, 2d ed and A Discursive Dictionary of Health Care, US House of Representatives, 1976)Lung Transplantation: The transference of either one or both of the lungs from one human or animal to another.Liver Diseases: Pathological processes of the LIVER.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Disease Transmission, Infectious: The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).Purchasing, Hospital: Hospital department responsible for the purchasing of supplies and equipment.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Tissue Preservation: The process by which a tissue or aggregate of cells is kept alive outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Multiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Tissue Kallikreins: A family of trypsin-like SERINE ENDOPEPTIDASES that are expressed in a variety of cell types including human prostate epithelial cells. They are formed from tissue prokallikrein by action with TRYPSIN. They are highly similar to PROSTATE-SPECIFIC ANTIGEN.Blood-Borne Pathogens: Infectious organisms in the BLOOD, of which the predominant medical interest is their contamination of blood-soiled linens, towels, gowns, BANDAGES, other items from individuals in risk categories, NEEDLES and other sharp objects, MEDICAL WASTE and DENTAL WASTE, all of which health workers are exposed to. This concept is differentiated from the clinical conditions of BACTEREMIA; VIREMIA; and FUNGEMIA where the organism is present in the blood of a patient as the result of a natural infectious process.Facial Transplantation: The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.Organ Size: The measurement of an organ in volume, mass, or heaviness.Morals: Standards of conduct that distinguish right from wrong.Dissection: The separation and isolation of tissues for surgical purposes, or for the analysis or study of their structures.Organ of Corti: The spiral EPITHELIUM containing sensory AUDITORY HAIR CELLS and supporting cells in the cochlea. Organ of Corti, situated on the BASILAR MEMBRANE and overlaid by a gelatinous TECTORIAL MEMBRANE, converts sound-induced mechanical waves to neural impulses to the brain.Decision Making: The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.Pancreas: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.Pancreas Transplantation: The transference of a pancreas from one human or animal to another.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Deltaretrovirus Infections: Infections caused by the HTLV or BLV deltaretroviruses. They include human T-cell leukemia-lymphoma (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED).Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cold Ischemia: The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.Rabies virus: The type species of LYSSAVIRUS causing rabies in humans and other animals. Transmission is mostly by animal bites through saliva. The virus is neurotropic multiplying in neurons and myotubes of vertebrates.Commission on Professional and Hospital Activities: The non-profit, non-governmental organization which collects, processes, and distributes data on hospital use. Two programs of the Commission are the Professional Activity Study and the Medical Audit Program.Financial Management: The obtaining and management of funds for institutional needs and responsibility for fiscal affairs.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Tissue and Organ ProcurementTissue DonorsBrain DeathOrgan TransplantationPresumed ConsentTissue and Organ HarvestingCadaverDonor SelectionWaiting ListsTissue BanksLiving DonorsDeathLiver TransplantationKidney TransplantationDirected Tissue DonationOrgan PreservationTransplantationUnited States Health Resources and Services AdministrationGraft SurvivalPrinciple-Based EthicsTransplantsFacility Regulation and ControlInformed ConsentUnited StatesHealth Care RationingHeart TransplantationValue-Based PurchasingEnd Stage Liver DiseaseFamilyEthics, MedicalRetrospective StudiesLiver FailureBlood DonorsTime FactorsRegistriesGraft RejectionTransplantation, HomologousPatient SelectionSculptureTreatment OutcomeOrgan SpecificityThird-Party ConsentAltruismDrugs, EssentialInsurance, LifeDelayed Graft FunctionOrgan Preservation SolutionsPosthumous ConceptionMedicareLung TransplantationLiver DiseasesLiverRisk AssessmentDisease Transmission, InfectiousPurchasing, HospitalTissue DistributionTissue PreservationMultiple Organ FailureMolecular Sequence DataTissue KallikreinsBlood-Borne PathogensFacial TransplantationOrgan SizeMoralsDissectionOrgan of CortiDecision MakingPancreasPancreas TransplantationFatal OutcomeDeltaretrovirus InfectionsProportional Hazards ModelsImmunohistochemistryKidneyBase SequenceAmino Acid SequenceCold IschemiaRabies virusCommission on Professional and Hospital ActivitiesFinancial ManagementRNA, Messenger
Organ donationOrgan donation
Portal for Organ Donation After Execution Portal for The National Network of Organ Donors Human Tissue Donation - NPR News ... The United Network for Organ Sharing and the Organ Procurement and Transplant Network (OPTN) regulate Organ Procurement ... Human Services. Retrieved October 11, 2015. "Organ Donation Statistics: Why be an Organ Donor? , organdonor.gov". organdonor. ... and legalized organ procurement from brain dead donors. New Zealand law allows live donors to participate in altruistic organ ...
Intestine transplantationIntestine transplantation
Once donor preparation is accomplished, procurement can begin by utilizing the same standard techniques for all abdominal organ ... When determining potential donor-recipient matches, important characteristics include donor size, age, tissue quality, and ABO ... A complex assortment of microorganisms inhabits the human digestive tract, with concentrations of up to 104-107 CFU/mL in the ... If the donor and recipient organs do not meet compatibility requirements, the threat of organ rejection by the body is all but ...
Network for Pancreatic Organ Donors with DiabetesNetwork for Pancreatic Organ Donors with Diabetes
nPOD partners with Organ Procurement Organizations (OPOs) and tissue banks to identify deceased organ donors who wish to donate ... JDRF recognized this reality and took on the vision to create a biobank of human tissue for type 1 diabetes research, despite ... All donors are typed for the following HLA alleles: A, B, DRB1, and DQB1. The processing team, also known as the Organ ... The Network for Pancreatic Organ donors with Diabetes (nPOD), is a collaborative type 1 diabetes research project funded by ...
National Organ Transplant Act of 1984National Organ Transplant Act of 1984
... and Human Services will establish a Task Force on Organ Procurement and Transplantation to regulate how deceased donor organs ... and lease the human organs and tissues. Due to a shortage in organs but a growing demand for transplantations, people began to ... 101 "Organ Procurement Organizations." http://organdonor.gov. US Department of Human Health and Services. "Organ Procurement ... The 1988 Amendment of NOTA introduced the Organ Procurement Organizations and Organ Procurement and Transplantation Network ...
Kilgour-Matas reportKilgour-Matas report
... "deeply concerned about recent allegations regarding the procurement of organs and tissues through coercive or exploitative ... they abided by World Health Organization principles that prohibit the sale of human organs without written consent from donors ... Organ transplantation in ChinaEdit. Main article: Organ transplantation in China. China has had an organ transplantation ... a b National Kidney Foundation Statement about Alleged Human Rights Violations in Organ Donation National Kidney Foundation, 14 ...
Transplant coordinatorTransplant coordinator
... to removal or transplantation of human organs or tissues or both and for assisting the authority for removal of human organs. ... Transplant Procurement Management (TPM) is an international educational programme in organ and transplant coordination that ... It promotes knowledge transfer and development of professional competences in organ donation as key factors to maximize donor ... Qualification According to the Transplantation of Human Organs and Tissues Rules, 2014, the transplant coordinator shall be an ...
Organ Donation TaskforceOrgan Donation Taskforce
... page 54&55 Organ donor system overhaul call - BBC Online 13 Jan 2008 http://www.number10.gov.uk/Page14250 Human Tissue Act 2004 ... to identify barriers to organ donation to recommend what action needs to be taken to increase organ donation and procurement ... Under Part 1 of the Human Tissue Act 2004, it is unlawful to remove, store, or use human organs and other tissue for scheduled ... The Human Tissue Act 2004 covers England, Wales and Northern Ireland. The Human Tissue (Scotland) Act 2006 covers Scotland and ...
National Disease Research InterchangeNational Disease Research Interchange
... including organ procurement organizations (OPO), tissue banks, eye banks, and hospitals. The TSS, are distributed throughout ... is the nation's leading source of human tissues, cells and organs for scientific research. A not-for-profit 501 (c)(3) ... from donor populations with diverse demographics and also facilitates the timely and efficient provision of fresh tissues ... By serving as the liaison between procurement sources and the research community, NDRI is uniquely positioned to support ...
Human Transplantation (Wales) Act 2013Human Transplantation (Wales) Act 2013
... and created the Human Tissue Authority to "regulate the removal, storage, use and disposal of human bodies, organs and tissue ... In 2011/12, 67 people became organ donors in Welsh hospitals. Potentially, each donor could provide up to nine organs for ... and to recommend what action needed to be taken to increase organ donation and procurement. The ODTF's first report, 'Organs ... "Introduction" (PDF). Draft Human Transplantation (Wales) Bill and Explanatory Memorandum: Consent to organ and tissue donation ...
Organ transplantationOrgan transplantation
... corneal donor tissue is usually handled by various eye banks.) Individual regional organ procurement organizations (OPOs), all ... the Human Organ Transplants Act 1989 first made organ sales illegal, and has been superseded by the Human Tissue Act 2004. In ... all deceased organ donors had died of circulatory death. These organs have inferior outcomes to organs from a brain-dead donor. ... Organ donors may be living, brain dead, or dead via circulatory death.[1] Tissue may be recovered from donors who die of ...
Healthcare Systems BureauHealthcare Systems Bureau
In FY 2008, HRSA provided $23 million to promote the donation of organs and tissues and improve national procurement, ... of the United States Department of Health and Human Services. HRSA oversees the nation's organ and tissue donation and ... Stem cells for transplant come from adult volunteer donors and umbilical cord blood units donated to public cord blood banks. ... HRSA oversees the Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients in ...
Eye bankEye bank
When an organ/tissue donor dies, consent for donation is obtained either from a donor registry or from the donor's next of kin ... "Terms and Topics - R". U.S. Department of Health and Human Services. Retrieved 2013-01-23. "Press Room". Michigan Organ Tissue ... Recovery is currently the preferred term, although "harvesting" and "procurement" have been used in the past, they are ... "Recovery" refers to the retrieval of organs or tissues from a deceased organ donor. ...
Paul TerasakiPaul Terasaki
In 1964, Terasaki developed the microcytotoxicity test, a tissue-typing test for organ transplant donors and recipients that ... Analysis of HLA incompatibility in human renal transplants. Tissue Antigens 1971; 2: 57-67. Terasaki PI, Cecka JM, Gjertson DW ... 1977). International Symposium on Kidney Procurement, Preservation, and Sharing for Clinical Transplantation, University of ... was an American scientist in the field of human organ transplant technology, and professor emeritus of surgery at UCLA School ...
Dialysis Clinic, IncDialysis Clinic, Inc
... it operated three organ procurement organizations: Tennessee Donor Services, New Mexico Donor Services, and Sierra Donor ... The Care of the Patient is Our Reason for Existence." Facilitating kidney and other organ and tissue donation was the logical ... in DCI facilities to ensure the research is scientifically rigorous and valid and that the appropriate procedures for human ... Services, in California, and one tissue bank: DCI Donor Services Tissue Bank. DCI Laboratory, founded in 1988 as a division of ...
Organ tradeOrgan trade
... is the trade of human organs, tissues or other body parts for the purpose of transplantation. There is a global ... In one study of organ donors in India, 71% of all donors fell below the poverty line. Tales of organ theft usually characterize ... Thus, what needs to be regulated, according to these authors, is organ procurement and distribution practices. Jason Brennan ... Legalization of human organ trading has been opposed by a variety of human rights groups. One such group is Organs Watch, which ...
Brainstem deathBrainstem death
J Roy Coll Physns of London 1995;29:381-2 The Transplantation of Human Organs Act, 1994. Act No.42 of 1994. s. 2 Human Tissue ... There is published evidence strongly suggestive of the persistence of brainstem blood pressure control in organ donors. A small ... acceptable for legal purposes in the UK in the context of organ procurement for transplantation) by the specified testing of ... Hemodynamic responses in brain dead organ donor patients. Anesthesia and Analgesia 1985;64:125-8 Pennefather SH, Dark JH, ...
Center for Medical ProgressCenter for Medical Progress
... called Biomax Procurement Services. Under this guise, they posed as potential buyers of aborted fetal tissue and organs, and ... a Texas judge dismissed the misdemeanor charge of purchase and sale of human organs due to a technicality in the Harris County ... "Group Behind Planned Parenthood Sting Video May Have Tricked IRS, Donors". The Huffington Post. July 17, 2015. "Sting Videos ... "sham procurement contracts," offering US$1,600 for liver and thymus fetal tissues. The videos and allegations attracted ...
Organ giftingOrgan gifting
As Sharp has indicated, "through organ procurement, human bodies are commodified and codified following a relatively strict ... the negative effects of compensating blood donors and the benefits of maintaining a system where the donation of body tissues ... Several authors have used the terms organ gifting and "tissue gifting" to describe processes behind organ and tissue transfers ... Organ receivers are also interested in obtaining information about donors. As Lock has mentioned, "organ recipients worry about ...
Uniform Anatomical Gift ActUniform Anatomical Gift Act
As of 2016, there were less organ donors registered than the amount of people that are in need of an organ or tissue transplant ... "State Organ Donor Legislation". OrganDonor.Gov. U.S. Department of Health and Human Services. 2011. Retrieved April 3, 2017. ... Association of Organ Procurement Organizations (AOPO) Gift of Life Donate Life America: Organ Donor Registration. ... UAGA governs organ donations for the purpose of transplantation. The Act permits any adult to become an organ donor. It also ...
Organ procurementOrgan procurement
If the organ donor is human, most countries require that the donor be legally dead for consideration of organ transplantation ( ... Organ procurement (previously called organ harvesting) is a surgical procedure that removes organs or tissues for reuse, ... "Organ Donation Statistics: Why be an Organ Donor? , organdonor.gov". www.organdonor.gov. Retrieved 2017-12-06. CNN, Susan ... Organ transplantation in China Organ harvesting from Falun Gong practitioners in China Operation Bid Rig "Tissue and Organ ...
Steve OelrichSteve Oelrich
The yearly event is named after Oelrich's son, Nick, an organ and tissue donor, who saved or enhanced the lives of one hundred ... and Health and Human Services Appropriations. In 2012, Florida Senate districts were reconfigured, and rather than run for a ... Alachua County District Chairman Big Brothers/Big Sisters University of Florida Procurement Organization's Advisory Board ... foundation is to promote organ and tissue donation. ... Board of Directors The United Network for Organ Sharing (UNOS ...
Kidney transplantationKidney transplantation
Tissue typing was simple, the organ was relatively easy to remove and implant, live donors could be used without difficulty, ... human leukocyte antigen - HLA) compatible. If a potential living donor is incompatible with their recipient, the donor could be ... ISBN 1-84816-497-1. Organ Procurement and Transplantation Network, 2007 Organización Nacional de Transplantes (ONT), 2007 "How ... or living-donor transplantation depending on the source of the donor organ. Living-donor renal transplants are further ...
Kidney transplantationKidney transplantation
Tissue typing was simple, the organ was relatively easy to remove and implant, live donors could be used without difficulty, ... human leukocyte antigen - HLA) compatible. If a potential living donor is incompatible with their recipient, the donor could be ... "The Organ Procurement and Transplant Network (OPTN). Archived from the original on 2009-04-17. Retrieved 2009-05-07.. (the link ... Deceased donorsEdit. Kidney donor cards from England, 1971-1981. The cards were made to be carried by donors as evidence that ...
David DaleidenDavid Daleiden
In 2015, Daleiden released videos showing Planned Parenthood officials discussing fees for human fetal tissue and organs. ... In furtherance of his plan, he set up a sham biomedical research company called Biomax Procurement Services. Daleiden and his ... "Group Behind Planned Parenthood Sting Video May Have Tricked IRS, Donors". The Huffington Post. July 17, 2015. Retrieved 28 ... Planned Parenthood asserts that they may donate fetal tissue at the request of a patient, but such tissue is never sold. ...
Meniscus transplantMeniscus transplant
However, it has been shown to degrade most collagen-based tissues and the meniscus is particularly susceptible. Tissue ... However, inherent variability in both the positioning of the knee and the direction of the x-ray beam, as well as human error ... Webber, RJ; York, JL; Vanderschilden, JL; Hough AJ, Jr (May-Jun 1989). "An organ culture model for assaying wound repair of the ... Matching the size of the donor knee to the size of the recipient knee is crucial for successful meniscus transplantation. ...
Lung allocation scoreLung allocation score
The lung allocation score (LAS) is a numerical value used by the United Network for Organ Sharing (UNOS) to assign relative priority for distributing donated lungs for transplantation within the United States. The lung allocation score takes into account various measures of a patient's health in order to direct donated organs towards the patients who would best benefit from a lung transplant. The LAS system replaces the older method within the United States of allocating donated lungs strictly on a first-come, first-served basis, according to blood type compatibility and distance from the donor hospital. The older method is still used for patients under the age of 12. The LAS system is still being evaluated and revised.[1] The reason for this continuing analysis is the need to balance on one hand the desire to help those patients in direct need, versus the statistical likelihood of the patient to survive the procedure, as ...
Organ donation in Jewish lawOrgan donation in Jewish law
Certain fundamental Jewish law questions arise in issues of organ donation. Donation of an organ from a living person to save another's life, where the donor's health will not appreciably suffer, is permitted and encouraged in Jewish law. Donation of an organ from a dead person is equally permitted for the same purpose: to save a life (pikuach nefesh). This simple statement of the issue belies, however, the complexity of defining death in Jewish law. Thus, although there are side issues regarding mutilation of the body etc., the primary issue that prevents organ donation from the dead amongst Jews, in many cases, is the definition of death, simply because to take a life-sustaining organ from a person who was still alive would be murder. Because in Jewish law, organ donation raises such ...
Information Services Procurement LibraryInformation Services Procurement Library
The Information Services Procurement Library (ISPL) is a best practice library for the management of Information Technology related acquisition processes. It helps both the customer and supplier organization to achieve the desired quality using the corresponded amount of time and money by providing methods and best practices for risk management, contract management, and planning. ISPL focuses on the relationship between the customer and supplier organization: It helps constructing the request for proposal, it helps constructing the contract and delivery plan according to the project situation and risks, and it helps monitoring the delivery phase. ISPL is a unique Information Technology method because where most other Information Technology methods and frameworks focus on development (e.g. DSDM, RUP), ISPL focuses purely on the procurement of information services. The target audience for ISPL consists of ...
American Journal of TransplantationAmerican Journal of Transplantation
The American Journal of Transplantation is a monthly peer-reviewed medical journal published by Wiley-Blackwell on behalf of the American Society of Transplant Surgeons and the American Society of Transplantation. It covers research on all aspects of organ transplantation. Each issue offers continuing medical education in the form of its Images in Transplantation feature, a case-based approach. The journal was established in 2001 with Philip F. Halloran (University of Alberta) as its first editor-in-chief. In 2011, he was succeeded by Allan D. Kirk (Duke University). From 2011 to 2015, a shorter, Czech language-version of the journal was published quarterly, each issue containing five articles originally published in the American Journal of Transplantation. The local editor was Ondrej Viklický (Institute for Clinical and Experimental Medicine, Prague). The journal publishes a yearly supplement, the Organ Procurement and ...
Kidney Paired DonationKidney Paired Donation
... (KPD) or Paired Exchange, is an approach to living donor kidney transplantation where patients with incompatible donors swap kidneys to receive a compatible kidney. KPD is used in situations where a potential donor is incompatible. Because better donor HLA and age matching are correlated with lower lifetime mortality and longer lasting kidney transplants, many compatible pairs are also participating in swaps to find better matched kidneys. In the United States, the National Kidney Registry organizes the majority of U.S. KPD transplants, including the largest swaps. The first large swap was a 60 participant chain in 2012 that appeared on the front page of the New York Times and the second, even larger swap, included 70 participants and was completed in 2014. Other KPD programs in the U.S. include the UNOS program which was launched in 2010 and completed its 100th KPD transplant in 2014 and the Alliance ...
Kidney transplantationKidney transplantation
Approximately one in three donations in the US, UK, and Israel is now from a live donor.[13][14][15] Potential donors are carefully evaluated on medical and psychological grounds. This ensures that the donor is fit for surgery and has no disease which brings undue risk or likelihood of a poor outcome for either the donor or recipient. The psychological assessment is to ensure the donor gives informed consent and is not coerced. In countries where paying for organs is illegal, the authorities may also seek to ensure that a donation has not resulted from a financial transaction. The relationship the donor has to the recipient has evolved over the years. In the 1950s, the first successful living donor transplants were between identical twins. In the 1960s-1970s, live donors were genetically related to the recipient. However, during the ...
Inter vivosInter vivos
... (Latin, between the living) is a legal term referring to a transfer or gift made during one's lifetime, as opposed to a testamentary transfer (a gift that takes effect on death) under the subject of trust. The term is often used to describe a trust established during one's lifetime, i.e., an Inter vivos trust as opposed to a Testamentary trust which is established on one's death, usually as part of a will. An Inter vivos trust is often used synonymously with the more common term Living trust, but an Inter vivos trust, by definition, includes both revocable and irrevocable trusts. The term inter vivos is also used to describe living organ donation, in which one patient donates an organ to another while both are alive. Generally, the organs transplanted are either non-vital organs such as corneas or redundant vital organs such as one of ...
Walter PaytonWalter Payton
Payton's legacy continues through the charitable Walter and Connie Payton Foundation. His own appeals-and after his death, his foundation's-for greater awareness of the need for organ donations are widely credited with bringing national attention to the problem.[47] After his appeals, donations in Illinois skyrocketed, and the regional organ bank of Illinois was overwhelmed with calls.[48] In response, the City of Chicago inserted organ donation requests into city-vehicle-registration mailings in early 2000, and by August 2000, 13,000 people had signed on to the program.[49] The foundation continues to run a program that Payton organized to donate toys to underprivileged children across the Chicago area each Christmas.[9] The family established the Walter Payton Cancer Fund in 2002.[50]. Many modern NFL running backs have cited Payton as a source of inspiration. Emmitt Smith ...
Procurement AdminProcurement Admin
... on WN Network delivers the latest Videos and Editable pages for News & Events, including Entertainment, Music, Sports, Science and more, Sign up and share your playlists.
Kilgour-Matas reportKilgour-Matas report
The report's allegations of involuntary organ removal from Falun Gong adherents received considerable media coverage, particularly in Canada, Europe, and Australia. Several governments tightened transplant tourism practices and requested more information from the Chinese government. Chinese officials repeatedly and angrily denied the report's organ harvesting allegations.[3][4] Upon release of the initial report, China declared they abided by World Health Organization principles that prohibit the sale of human organs without written consent from donors and denounced the report. Amnesty International in 2006 said it was "continuing to analyze sources of information" about the allegations.[50] David Ownby, a professor of history at the University of Montreal and expert on Falun Gong, wrote in Falun Gong and the Future of China that Falun Gong ...
PlasmapheresisPlasmapheresis
Donating plasma is similar in many ways to whole blood donation, though the end product is used for different purposes. Most plasmapheresis is for fractionation into other products; other blood donations are transfused with relatively minor modifications. Plasma that is collected solely for further manufacturing is called Source Plasma. Plasma donors undergo a screening process to ensure both the donor's safety and the safety of the collected product. Factors monitored include blood pressure, pulse, temperature, total protein, protein electrophoresis, health history screening similar to that for whole blood, as well as an annual physical exam with a licensed physician or an approved physician substitute under the supervision of the physician. Donors are screened at each donation for viral diseases that can be transmitted by blood, sometimes by multiple methods. For example, donations are tested for HIV by ELISA, which shows if they have been exposed to the ...
NHS Blood and TransplantNHS Blood and Transplant
... (NHSBT) is an executive non-departmental public body of the United Kingdom's Department of Health. It was established on 1 October 2005 to take over the responsibilities of two separate NHS agencies: UK Transplant (now renamed Organ Donation and Transplantation), founded by Dr. Geoffrey Tovey in 1972, and the National Blood Service (now renamed Blood Donation). Its remit is to provide a reliable, efficient supply of blood, organs and associated services to the NHS. Since NHSBT was established, the organisation has maintained or improved the quality of the services delivered to patients, stabilised the rising cost of blood, and centralised a number of corporate services. NHSBT has the responsibility for optimising the supply of blood, organs and tissues and raising the quality, effectiveness and efficiency of blood and transplant services. NHSBT's roles ...
Organél - Wikipédia Sunda, énsiklopédi bébasOrganél - Wikipédia Sunda, énsiklopédi bébas
Eukariot mangrupa tipeu sél anu wangunanana paling pajeulit nu ditata dina rohangan-rohangan jeroan anu leuwih leutik nu dibungkus ku mémbran lipid. Organél-organél nu leuwih badag kayaning inti sél jeung vakuola bisa katempo ku mikroskop biasa (najan kadang perlu dibantu ku pewarna). Henteu sakabéh sél eukariot miboga organél-organél nu kasebut di handap. ...
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Tissue and Organ ProcurementTissue DonorsBrain DeathOrgan TransplantationPresumed ConsentTissue and Organ HarvestingCadaverDonor SelectionWaiting ListsTissue BanksLiving DonorsDeathLiver TransplantationKidney TransplantationDirected Tissue DonationOrgan PreservationTransplantationUnited States Health Resources and Services AdministrationGraft SurvivalPrinciple-Based EthicsTransplantsFacility Regulation and ControlInformed ConsentUnited StatesHealth Care RationingHeart TransplantationValue-Based PurchasingEnd Stage Liver DiseaseFamilyEthics, MedicalRetrospective StudiesLiver FailureBlood DonorsTime FactorsRegistriesGraft RejectionTransplantation, HomologousPatient SelectionSculptureTreatment OutcomeOrgan SpecificityThird-Party ConsentAltruismDrugs, EssentialInsurance, LifeDelayed Graft FunctionOrgan Preservation SolutionsPosthumous ConceptionMedicareLung TransplantationLiver DiseasesLiverRisk AssessmentDisease Transmission, InfectiousPurchasing, HospitalTissue DistributionTissue PreservationMultiple Organ FailureMolecular Sequence DataTissue KallikreinsBlood-Borne PathogensFacial TransplantationOrgan SizeMoralsDissectionOrgan of CortiDecision MakingPancreasPancreas TransplantationFatal OutcomeDeltaretrovirus InfectionsProportional Hazards ModelsImmunohistochemistryKidneyBase SequenceAmino Acid SequenceCold IschemiaRabies virusCommission on Professional and Hospital ActivitiesFinancial ManagementRNA, Messenger
Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling | DiabetesComparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling | Diabetes
Two matched samples of jejunum and terminal ileum were collected during organ procurement from transplant donors. Data were ... Human Tissue Transcriptome. Sample Collection. Jejunal tissue was obtained from 11 human participants (Supplementary Table 1). ... Tissue samples from different regions of the human GI tract for LC-MS/MS were obtained from Addenbrookes Human Research Tissue ... Comparison between human and mouse jejunum peptidome. Tissue samples were analyzed by nano-LC-MS/MS and compared between human ...
diabetes.diabetesjournals.org
Living organ donation FAQs | Human Tissue AuthorityLiving organ donation FAQs | Human Tissue Authority
The standards cover both procurement (characterisation of donor; characterisation, retrieval, preservation and transport of an ... What about the illegal trade of organs? The buying or selling of organs or human tissue is illegal under the Human Tissue Act ... When did the Human Tissue Authority start regulating living organ donation? The Human Tissue Authority (HTA) has been ... Can donors be paid or rewarded for donating an organ? It is unlawful for donors to be paid or rewarded for donating an organ or ...
hta.gov.uk
BPAC Meeting - 12/4-12/5/12BPAC Meeting - 12/4-12/5/12
... oversees the transplantation of human organs; organ donor testing policies are established by the Organ Procurement and ... in addition to regulating assays for blood and tissue donors and diagnostic tests). To date, organ donor screening indications ... while there are about 8,000 organ donors (donating 22,000 organs each year). It was noted that the organ donor pool is ... Near highlighted the fact that under OPTN Policy 2.2.3, Screening Potential Organ Donor, all potential organ donors must be ...
aabb.org
Epidemiologic Notes and Reports Testing Donors of Organs, Tissues, and Semen for Antibody to Human T-Lymphotropic Virus Type ...Epidemiologic Notes and Reports Testing Donors of Organs, Tissues, and Semen for Antibody to Human T-Lymphotropic Virus Type ...
It is recognized that the circumstances of organ procurement and the logistics of transplantation may in some instances not ... Epidemiologic Notes and Reports Testing Donors of Organs, Tissues, and Semen for Antibody to Human T-Lymphotropic Virus Type ... It is additionally recommended that blood or serum from donors of organs, tissues, or semen intended for human use be similarly ... Thus, organs, tissues, and semen obtained from HTLV-III/LAV antibody-positive persons must be considered as potentially ...
cdc.gov
Effect of collaborative requesting on consent rate for organ donation: randomised controlled trial (ACRE trial) | The BMJEffect of "collaborative requesting" on consent rate for organ donation: randomised controlled trial (ACRE trial) | The BMJ
1 Although in the UK the Human Tissue Act 2004 prioritises the wishes and consent of the potential organ donor over his or her ... Consent for donation is therefore likely to remain an important step in organ procurement for the foreseeable future. ... Why the undoubted extra experience of the donor transplant coordinators in interviewing the relatives of potential organ donors ... Interventions Collaborative requesting for consent for organ donation by the potential donors clinician and a donor transplant ...
bmj.com
Regulating human embryonic stem cell lines for human application | Human Tissue AuthorityRegulating human embryonic stem cell lines for human application | Human Tissue Authority
... their derivation in the laboratory through to their clinical application.The HFEA is responsible for regulating the procurement ... The aim of regulating human embryonic stem cells is to ensure that the highest standards are met from ... The HTA is also responsible for approving transplantation of solid organs and bone marrow from living donors.. HFEA. The HFEA ... The HTA was established on 1 April 2005 to regulate the removal, storage, use and disposal of human bodies, organs and tissue ...
hta.gov.uk
Science Clips - Volume 12, Issue 21, June 30, 2020Science Clips - Volume 12, Issue 21, June 30, 2020
Assessing solid organ donors and monitoring transplant recipients for human immunodeficiency virus, hepatitis B virus, and ... donors with laboratory evidence of HCV infection are included but are not required to be incorporated into Organ Procurement ... tissues, corneas, and breast milk). The recommendations pertain to transplantation of solid organs procured from donors without ... among solid organ donors, implementation of laboratory screening of solid organ donors, and monitoring of solid organ ...
cdc.gov
The Seamy Side Of The Human Tissue Business | HPPRThe Seamy Side Of The Human Tissue Business | HPPR
Part 4 in a four-part series The human tissue industry has created medical advances for millions of Americans. Tissue taken ... Unlike organ donation, where a heart or kidney goes straight from a donor to a recipient, tissue goes through many steps. Is ... A procurement team takes the body parts. Thats another fee. Then companies take the parts and turn them into scores of medical ... Unlike organ donation, where a heart or kidney goes straight from a donor to a recipient, tissue goes through many steps. ...
hppr.org
Transplanting Human Tissue: Ethics, Policy and Practice, Book by Stuart J. Youngner (Hardcover) | chapters.indigo.caTransplanting Human Tissue: Ethics, Policy and Practice, Book by Stuart J. Youngner (Hardcover) | chapters.indigo.ca
Buy the Hardcover Book Transplanting Human Tissue by Stuart J. Youngner at Indigo.ca, Canadas largest bookstore. + Get Free ... Association of Organ Procurement Organizations, Eye Bank Association of AmericaB. Donors Bill of Rights National Donor Family ... Ellen Gottman Kulik: The Gift of Tissue: A Donor Moms PerspectivePart III8. R. Alta Charo: Legal Characterizations of Human ... Model Elements of Informed Consent for Organ and Tissue Donation American Association of Tissue Banks, ...
chapters.indigo.ca
Research | Columbia Center for Translational ImmunologyResearch | Columbia Center for Translational Immunology
... where they obtain multiple lymphoid and mucosal tissues from research-consented human organ donors. See the Farber Lab website ... For their translational studies, they have established a unique collaboration and research protocol with the organ procurement ... We are investigating T cell responses within celiac disease through the study of blood and tissue from human volunteers. We ... Development of inbred miniature swine as a model for large animal transplantation studies and as donors of organs for ...
cumc.columbia.edu
Transplantation of the heart after circulatory death of the donor: time for a change in law? | The Medical Journal of AustraliaTransplantation of the heart after circulatory death of the donor: time for a change in law? | The Medical Journal of Australia
... a purpose of the Act is to prevent tissue and organ procurement from a donor who is not dead. Thus, heart procurement for ... In Victoria, the stated aim of the Human Tissue Act is to make provision for removal of human tissue for transplantation and, ... The procurement of organs is specified in the Australian national DCD protocol published by the Organ and Tissue Authority9 and ... We favour novel legislation for organ procurement from donors not fulfilling the so-called dead donor rule. We have already ...
mja.com.au
Need For Human Organ Donors Serious - tribunedigital-chicagotribuneNeed For Human Organ Donors Serious - tribunedigital-chicagotribune
You have published several articles relating to the serious shortage of organs needed for transplants. Perhaps your readers are ... 1, 1986, that requires hospitals to develop a protocol for identifying potential organ and tissue donors. ... according to the Regional Organ Procurement Agency of Southern California. (Many are children.) ... Families will be asked at--or near--the time of death whether or not the patient is a donor, or if they are a donor family. If ...
articles.chicagotribune.com
JoVE | Peer Reviewed Scientific Video Journal - Methods and ProtocolsJoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, donor characteristic, organ procurement and preservation affect the isolation outcome 2. At University of Illinois at ... Here we describe a protocol for extracting proteins from human tissues in a format that is not toxic to human T cells. The ... However, donor characteristics, organ procurement and preservation affect the isolation outcome 2. At University of Illinois at ... Medicine, Issue 27, Human islets, Type 1 diabetes, pancreatic tissue, digestion, human islet transplantation ...
jove.com
JoVE | Peer Reviewed Scientific Video Journal - Methods and ProtocolsJoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, donor characteristics, organ procurement and preservation affect the isolation outcome 2. At University of Illinois at ... As described in Part I: Digestion and Collection of Pancreatic Tissue, human pancreas was trimmed, cannulated, perfused, and ... Medicine, Issue 27, Human islets, Type 1 diabetes, human islet purification, human islet transplantation ... Thereafter, the tissue homogenate was centrifuged in bovine serum albumin to separate vessel fragments from nervous tissue. The ...
jove.com
Frontiers | Mapping of NKp46+ Cells in Healthy Human Lymphoid and Non-Lymphoid Tissues | ImmunologyFrontiers | Mapping of NKp46+ Cells in Healthy Human Lymphoid and Non-Lymphoid Tissues | Immunology
In mouse, NK cells have been detected in various lymphoid and non-lymphoid organs, while in humans the current knowledge of NK ... the distribution and the phenotype of human NKp46+ cells in lymphoid and non-lymphoid tissues isolated from healthy donors. ... the distribution and the phenotype of human NKp46+ cells in lymphoid and non-lymphoid tissues isolated from healthy donors. ... while in humans the current knowledge of NK cell distribution at steady state is mainly restricted to lymphoid tissues. The ...
frontiersin.org
Careers | Carolina Donor ServicesCareers | Carolina Donor Services
Donor Services maximizes the passing of the heroic gift of life from one human being to another through organ and tissue ... Carolina Donor Services Overview Carolina Donor Services is the federally designated organ procurement organization serving 7.2 ... Carolina Donor Services Overview. Carolina Donor Services is the federally designated organ procurement organization serving ... increase the awareness of the need for organ and tissue donors and to deliver the most sensitive approach to organ and tissue ...
carolinadonorservices.org
ADME/Tox Support - Getting Started | Thermo Fisher Scientific - USADME/Tox Support - Getting Started | Thermo Fisher Scientific - US
TRANSiPORT human solute carrier (SLC) transporter cells, and HepaRG cells for performing target-based ADME/Tox assays. ... Are there guidelines for the procurement of human liver tissue for cryopreserved human hepatocytes? ... as well as from deceased donors whose organs were rejected for transplant. ... Where do you get liver tissue for cryopreserved human hepatocytes? We source liver tissue from a network of hospitals in North ...
thermofisher.com
Mapping the Genetic Architecture of Gene Expression in Human LiverMapping the Genetic Architecture of Gene Expression in Human Liver
... postmortem tissue and surgical resections from organ donors and were obtained from the Nashville Regional Organ Procurement ... E) Expression levels of RPS26 in 50 human tissues and cell lines. The tissues and cell lines are given along the y-axis, and ... F) Expression levels of Erbb3 in 50 human tissues and cell lines. The tissues and cell lines are given along the y-axis, and ... To characterize the genetic architecture of gene expression in human liver, we compiled a tissue-specific human liver cohort ( ...
pubmedcentralcanada.ca
First Atlas of B-cell Clones in Human Body Forms New Foundation for Infectious Disease Research | Lab ManagerFirst Atlas of B-cell Clones in Human Body Forms New Foundation for Infectious Disease Research | Lab Manager
"The donors, the research surgeons who performed the tissue acquisition, and the organ procurement organization, LiveOnNY, were ... Co-author Donna Farber, from Columbia University, directed the organ donor tissue program for acquiring the tissue samples. " ... They did this with the help of consented human organ donors who allowed their tissues to be used for research purposes, in ... Praks team traced over 933,000 B-cell lineages and replicated their results using the tissues from the six organ donors. "In ...
labmanager.com
The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and...The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and...
... from 5 donors), and 3 spleens were studied. The regional Organ Procurement Organization procured 5 human mesenteric lymph nodes ... Secondary lymphoid organ cell isolation and culture. Fifteen lymph nodes (from 10 donors), 8 palatine tonsils ( ... Subsets of NK cells in human secondary lymphoid organs. Mononuclear cells isolated from lymph nodes, spleens, and tonsils were ... Production of human cells expressing individual transferred HLA-A, -B, -C genes using an HLA-A, -B, -C null human cell line. J ...
jimmunol.org
Guidelines for Prev. Transmis. HIV: Transpl. Human Tissue & OrgansGuidelines for Prev. Transmis. HIV: Transpl. Human Tissue & Organs
Guidelines for Preventing Transmission of Human Immunodeficiency Virus Through Transplantation of Human Tissue and Organs ... even if it follows the procurement and/or transplant of the organs or tissues. * Results of HIV testing for organ/tissue donors ... Recall of Stored Tissue and Tracking of Recipients of Organs/Tissue from HIV-Infected Donors *Upon being notified that an organ ... Approximately 66 Organ Procurement Organizations (OPOs) and 260 organ transplant centers are members of the Organ Procurement ...
wonder.cdc.gov
42 U.S.C. § 273 (2014) - Organ procurement organizations :: Title 42 - The Public Health and Welfare (Sections 1 - 18445) - US...42 U.S.C. § 273 (2014) - Organ procurement organizations :: Title 42 - The Public Health and Welfare (Sections 1 - 18445) - US...
... and distribution of tissues as may be appropriate to assure that all useable tissues are obtained from potential donors, ... and social issues presented by human organ procurement and transplantation, with the final report due not later than 12 months ... including the organ donation coordinators and organ procurement specialists necessary to effectively obtain organs from donors ... 3) An organ procurement organization shall-. (A) have effective agreements, to identify potential organ donors, with a ...
law.justia.com
Sensitivity of Ocular Anterior Chamber Tissues to Oxidative Damage and Its Relevance to the Pathogenesis of Glaucoma | IOVS |...Sensitivity of Ocular Anterior Chamber Tissues to Oxidative Damage and Its Relevance to the Pathogenesis of Glaucoma | IOVS |...
The procurement of the human tissues conformed to the tenets of the Declaration of Helsinki. ... These samples were obtained from six organ donors from whom eyes were obtained for corneal transplant within 3 hours after ... AC tissues (cornea, TM, and iris) as collected from corneal donors. Molecular analyses were performed on the whole collected ... AC tissues (cornea, TM, and iris) as collected from corneal donors. Molecular analyses were performed on the whole collected ...
iovs.arvojournals.org
Utilisation of an embedded specialist nurse and collaborative care pathway increases potential organ donor referrals in the...Utilisation of an embedded specialist nurse and collaborative care pathway increases potential organ donor referrals in the...
... end-of-life wishes are identified and acted upon as set out in the Human Tissue Act, 2006.5 ... In-house organ procurement organization staff located in level 1 trauma centres increase conversion of potential donors to ... The presence of an embedded SN:OD has been shown to increase the conversion of potential organ donors to actual organ donors.6 ... The SN:OD would then, after consulting the UK Organ Donor Register, assess the patients suitability to become an organ donor ...
emj.bmj.com
Targeting Calpain for Heart Failure Therapy | JACC: Basic to Translational ScienceTargeting Calpain for Heart Failure Therapy | JACC: Basic to Translational Science
... donor hearts without evidence of overt cardiac dysfunction were obtained through organ donor networks/organ procurement ... All human heart tissue samples were obtained under an organ research donation protocol approved by the institutional review ... Calpain Activity Is Increased in Human Heart Failure. (A) Calpain activity assay in myocardium from healthy donors (n = 4, 45.0 ... Human heart samples. Left ventricular (LV) samples from patients with ischemic or dilated cardiomyopathies were obtained from ...
basictranslational.onlinejacc.org
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Tissue and Organ ProcurementTissue DonorsBrain DeathOrgan TransplantationPresumed ConsentTissue and Organ HarvestingCadaverDonor SelectionWaiting ListsTissue BanksLiving DonorsDeathLiver TransplantationKidney TransplantationDirected Tissue DonationOrgan PreservationTransplantationUnited States Health Resources and Services AdministrationGraft SurvivalPrinciple-Based EthicsTransplantsFacility Regulation and ControlInformed ConsentUnited StatesHealth Care RationingHeart TransplantationValue-Based PurchasingEnd Stage Liver DiseaseFamilyEthics, MedicalRetrospective StudiesLiver FailureBlood DonorsTime FactorsRegistriesGraft RejectionTransplantation, HomologousPatient SelectionSculptureTreatment OutcomeOrgan SpecificityThird-Party ConsentAltruismDrugs, EssentialInsurance, LifeDelayed Graft FunctionOrgan Preservation SolutionsPosthumous ConceptionMedicareLung TransplantationLiver DiseasesLiverRisk AssessmentDisease Transmission, InfectiousPurchasing, HospitalTissue DistributionTissue PreservationMultiple Organ FailureMolecular Sequence DataTissue KallikreinsBlood-Borne PathogensFacial TransplantationOrgan SizeMoralsDissectionOrgan of CortiDecision MakingPancreasPancreas TransplantationFatal OutcomeDeltaretrovirus InfectionsProportional Hazards ModelsImmunohistochemistryKidneyBase SequenceAmino Acid SequenceCold IschemiaRabies virusCommission on Professional and Hospital ActivitiesFinancial ManagementRNA, Messenger
RecipientsTransplantsOrganizationOrganizationsSolid organsAllocationBone marrowLymphoidUnited NetworkKidneyProcured from deceasedPotential organ donor2017Deceased organ donationCorneaConsentDonate organsPreservationBrain deathPediatric donorsShortage of organ and tissue donorsLungRelated organ and tissue donationFamiliesRegister to be a donorAdditionallyRegistryImmunodeficiency virusSuitableLegislationAmerican Association of Tissue BanksAllograftTransplantation in childrenNational OrganGraftLiver tissueHospitalsLiversHepatocytesSurgeonsCentersCells and tissues
Recipients24
Transplants19
Organization26
Organizations9
Solid organs5
Allocation4
Bone marrow1
  • A model of the human body showing distinct B cell clonal networks in the gastrointestinal tract and in the blood-rich organs such as bone marrow, spleen, and lung. (labmanager.com)
Lymphoid13
  • http://www.donatelifeny.org/ ) and transplant surgeons at New York Presbyterian (NYP) where they obtain multiple lymphoid and mucosal tissues from research-consented human organ donors. (columbia.edu)
  • In mouse, NK cells have been detected in various lymphoid and non-lymphoid organs, while in humans the current knowledge of NK cell distribution at steady state is mainly restricted to lymphoid tissues. (frontiersin.org)
  • Here, we documented the distribution and the phenotype of human NKp46 + cells in lymphoid and non-lymphoid tissues isolated from healthy donors. (frontiersin.org)
  • We hypothesize that IL-2 can mobilize the NK cells of secondary lymphoid tissues to mediate natural killing during immune responses. (jimmunol.org)
  • These results also suggest secondary lymphoid organs as a possible site of NK cell differentiation and self-tolerance acquisition. (jimmunol.org)
  • In contrast, the minority CD56 bright CD16 − NK cells from blood express receptors for homing to lymphoid tissues, such as CCR7, the receptor for CCL19 and CCL21 chemokines, and CD62L ( 6 ). (jimmunol.org)
  • Because lymph nodes contain 40% of all lymphocytes in humans, while blood harbors only 2% ( 8 , 9 ), NK cells of secondary lymphoid organs might be the predominant NK compartment in humans. (jimmunol.org)
  • We present in this study a comprehensive analysis of human NK cells in secondary lymphoid organs, emphasizing their differences from peripheral blood NK cells in inhibitory and activating receptors as well as cytolytic activity. (jimmunol.org)
  • We obtain multiple lymphoid, mucosal and exocrine tissues from donors of all ages of life, enabling unique investigations into how immune cells are distributed across the body and through the entire human lifespan. (farberlab.org)
  • We initially focused on investigation of human T cell subsets including naïve T cells that emerge from the thymus and populate lymphoid tissues, different memory T cell subsets that are generated after exposure to diverse antigens, pathogens and commensals, and regulatory T cells that arise in the thymus or the periphery (Thome, et al 2014, 2016). (farberlab.org)
  • In our studies on human TRM, we used whole transcriptome profiling to identify a core gene signature that defines TRM in multiple tissue sites, including mucosal and lymphoid tissues (Kumar, Ma, et al, 2017). (farberlab.org)
  • In our current studies, we are defining tissue-specific attributes of memory T cells within lymphoid sites (Miron, et al, submitted), intestines and the pancreas (unpublished), and the functional heterogeneity of human TRM and their responses to activation (Kumar, et al, submitted). (farberlab.org)
  • We have evaluated whether pancreatic islets and lymphoid tissues of T1D and nondiabetic organ donors differ in the amount and distribution of HA and HA-binding proteins (hyaladherins), such as inter-α-inhibitor (IαI), versican, and tumor necrosis factor-stimulated gene-6 (TSG-6). (diabetesjournals.org)
United Network5
Kidney21
Procured from deceased1
Potential organ donor2
  • 1 Although in the UK the Human Tissue Act 2004 prioritises the wishes and consent of the potential organ donor over his or her relatives, it is almost inconceivable that organs would be retrieved from a deceased donor against the wishes of relatives. (bmj.com)
  • The goal of this document is to provide critical care practitioners with essential information and practical recommendations related to management of the potential organ donor, based on the available literature and expert consensus. (nih.gov)
20172
  • a short A BBB video appeal was published in early 2017 The laws of different countries allow potential donors to permit or refuse donation, or give this choice to relatives. (wikipedia.org)
  • We are also examining the distribution of innate immune cells, including dendritic cells (DC) and NK cells in tissue sites over age (Granot, 2017 and unpublished) toward a complete mapping of the human immune system over space and time. (farberlab.org)
Deceased organ donation2
Cornea4
  • This study was conducted to comparatively evaluate the sensitivity to oxidative stress of anterior chamber tissues including the cornea, iris, and trabecular meshwork. (arvojournals.org)
  • Cornea, iris, and trabecular meshwork fragments collected from six cornea donors were either left untreated or treated with hydrogen peroxide. (arvojournals.org)
  • The trabecular meshwork was the most sensitive tissue to oxidative damage, as after exposure to hydrogen peroxide both markers of oxidative damage dramatically increased in the trabecular meshwork but not in the cornea and iris. (arvojournals.org)
  • We encourage individuals to make the pledge for life by registering to become an organ, tissue and cornea donor, which is also a wonderful way to show your love for others this Valentine's Day. (core.org)
Consent43
Donate organs1
  • At present only 28% of the UK population have registered their wish to donate organs by joining the NHS Organ Donor Register, despite 90% of the UK population supporting the concept of organ donation. (bmj.com)
Preservation6
Brain death8
Pediatric donors2
Shortage of organ and tissue donors1
Lung9
  • They've identified a new subset of non-circulating tissue-resident memory T cells (TRM) in the lung that mediate optimal protective immunity in a mouse model of influenza infection and have conducted studies into mechanisms for how memory T cells become targeted to and maintained in the lung use total transcriptome profiling and bioinformatics approaches. (columbia.edu)
  • Lung transplantation is the replacement of a diseased lung with a healthy lung from an organ donor, with the goal of improving the recipient's quality of life. (nm.org)
  • Thoracic surgeons remove small wedges of damaged lung tissue in order to help the remaining lung tissue function more efficiently. (nm.org)
  • We have used the human lung material received from IIAM to aid our drug discovery research by studying the biological role and disease relevance of proteins that may be of therapeutic relevance in lung disease. (iiam.org)
  • We have identified a new subset of non-circulating tissue-resident memory T cells (TRM) in the lung that mediate optimal protective immunity in a mouse model of influenza infection. (cumcweb.org)
  • Types of severe lung liver organ or harm fibrosis due to the helminths [8,or . (cancer-basics.com)
  • In 2011, we reported the identification and isolation of a subset of influenza-specific memory CD4+T cells in the lung that were generated in response to infection, were irreversibly retained in the lung tissue, and mediated optimal protective responses to influenza compared to circulating influenza-specific memory CD4+T cells (see Teijaro, et al, 2011). (farberlab.org)
  • Emphysema: The deterioration or loss of lung tissue, or the formation of cysts in the lungs. (lifepassiton.org)
  • Thus, oxidative stress plays a key role in the development of donor lung injury, which is mainly characterized by edema, ineffective gas exchange, increased levels of proinflammatory cytokines, and pulmonary infiltrates [ 6 , 7 ]. (hindawi.com)
Related organ and tissue donation1
Families16
  • Several families of people whose tissue was taken are suing RTI Biologics, Mastromarino's largest customer, for fraud. (hppr.org)
  • It traces the chain of distribution of musculoskeletal tissue (e.g. bones and ligaments) and skin from thegenerous donation of grieving families to its transplantation into hundreds of thousands of persons each year. (indigo.ca)
  • Commodification, commercialization, and the occassional use of tissue for 'cosmetic' surgery have raised ethical questions about the acceptability of 'markets' in human body parts thathave been altruistically donated by families. (indigo.ca)
  • Contributions to the book come from an interdisciplinary group of scholars, industry representatives, government regulators, and not least, families whohave donated tissue from their dead loved ones. (indigo.ca)
  • Families will be asked at--or near--the time of death whether or not the patient is a donor, or if they are a donor family. (chicagotribune.com)
  • We support families of babies with terminal diagnoses in contributing to medical advancement through organ donation. (iiam.org)
  • IIAM brings together donor families, medical research facilities and medical schools. (iiam.org)
  • We work with prominent research programs and provide a comforting option for donors and families. (iiam.org)
  • IIAM's Neonatal Donor Program enables families of neonatal babies with fatal fetal diagnoses to donate to medical research and education. (iiam.org)
  • Since its inception, IIAM's Neonatal Donor Program has helped families make donations to researchers, who are gaining insights into how organs and cells develop in ways that were once unthinkable. (iiam.org)
  • Donors and their families are not charged for any expenses related to the donation. (wikipedia.org)
  • Through our partnership with Gift of Hope Organ & Tissue Donor Network ( http://www.giftofhope.org/ ), we make donation an option for the families that we serve. (dupageco.org)
  • The Health Ministers felicitated and recognised the noble act of organ donation of several families of donors. (medindia.net)
  • You have inspired and motivated all of us through your act of strength and humanity in your saddest moments of life, and we salute all those breavehearts for being a source of life for the needy", Dr Harsh Vardhan said as he honoured many donor families. (medindia.net)
  • Donor families, best performing states, best performing hospitals, best performing transplant coordinators and states that have shown excellent performance in uploading maximum data in the national registry were felicitated and awarded at the event by the dignitaries. (medindia.net)
  • Since HPs are responsible for this approach to families, they are the gatekeepers for organ and tissue donor notification. (biomedcentral.com)
Register to be a donor1
Additionally2
Registry2
  • 2) The department of licensing shall submit a funding request to the legislature covering the reasonable costs associated with the ongoing maintenance associated with the electronic transfer of the donor information to the organ and tissue donor registry and the donation program established in RCW 46.16A.090 (2). (wa.gov)
  • Download , print and sign a donor card to carry with you if you haven't yet joined a donor registry. (pbs.org)
Immunodeficiency virus4
Suitable7
Legislation5
American Association of Tissue Banks1
Allograft5
Transplantation in children1
National Organ3
Graft1
  • Third, transplant programs are usually very conservative in the selection of donor lungs to avoid severe complications associated with primary graft dysfunction (PGD). (hindawi.com)
Liver tissue5
Hospitals10
Livers5
  • Human hepatic stem cells (hHpSCs), which are pluripotent precursors of hepatoblasts and thence of hepatocytic and biliary epithelia, are located in ductal plates in fetal livers and in Canals of Hering in adult livers. (rupress.org)
  • We define a novel class of AFP-negative cells in fetal and adult human livers that are precursors to hepatoblasts and have properties consistent with hHpSCs. (rupress.org)
  • We have previously reported that EpCAM+, AFP− cells from human livers are hHpSCs, and we have compared their pattern of gene expression with that of hepatoblasts and mature liver parenchyma ( 17 ). (rupress.org)
  • We now show that the hHpSCs are located in ductal plates in fetal and neonatal livers and in the proximal branches of the intrahepatic biliary tree, the Canals of Hering, in pediatric and adult livers of all donor ages, with the frequency of hHpSCs remaining relatively constant throughout life. (rupress.org)
  • Accordingly, we assessed NTCP mRNA expression from human livers using a sensitive RNase protection assay. (aspetjournals.org)
Hepatocytes9
Surgeons2
  • Although head trauma does not always imply facial trauma, surgeons should be aware that the facial tissue may be compromised in such cases. (bvsalud.org)
  • These two new sizes are the largest allografts available, offering surgeons a human tissue form that reduces the need to suture smaller sheets together. (bio-medicine.org)
Centers2
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (DHHS). (federalregister.gov)
Cells and tissues1
  • In the wake of failed clinical trials based on animal models, the pain field is facing what seems to be an inescapable conclusion: the success of new pain drugs in the clinic will likely require studies of human cells and tissues. (painresearchforum.org)