Neuregulin-1: A peptide factor originally identified by its ability to stimulate the phosphorylation the erbB-2 receptor (RECEPTOR, ERBB-2). It is a ligand for the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Variant forms of NEUREGULIN-1 occur through alternative splicing of its mRNA.Neuregulins: A family of peptides originally found as factors that stimulate the phosphorylation of the erbB-2 receptor (RECEPTORS, ERBB-2). Multiple variant forms of NEUREGULINS occur due to alternative splicing of their mRNAs. The NEUREGULINS include products from the three known genes (NGR1; NGR2 and NGR3).Receptor, erbB-3: A cell surface protein-tyrosine kinase receptor that is specific for NEUREGULINS. It has extensive homology to and can heterodimerize with the EGF RECEPTOR and the ERBB-2 RECEPTOR. Overexpression of the erbB-3 receptor is associated with TUMORIGENESIS.Receptor, erbB-2: A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.Receptor, Epidermal Growth Factor: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.Genes, erbB: Retrovirus-associated DNA sequences (erbB) originally isolated from, or related to, the avian erythroblastosis virus (AEV). These genes code for the epidermal growth factor receptor (EGFR) family of receptors which is important in the control of normal cell proliferation and in the pathogenesis of human cancer. The genes include erbB-1 (GENES, ERBB-1), erbB-2 (GENES, ERBB-2), and erbB-3, all of which show abnormalities of expression in various human neoplasms.Oncogenes: Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.Oncogene Proteins: Proteins coded by oncogenes. They include proteins resulting from the fusion of an oncogene and another gene (ONCOGENE PROTEINS, FUSION).Oncogene Proteins v-erbB: Transforming proteins encoded by erbB oncogenes from the avian erythroblastosis virus. The protein is a truncated form of the EGF receptor (RECEPTOR, EPIDERMAL GROWTH FACTOR) whose kinase domain is constitutively activated by deletion of the ligand-binding domain.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Genes, ras: Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.Oncogene Proteins, Viral: Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.Genes, erbB-2: The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.Oncogene Protein p21(ras): Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumors. This enzyme was formerly listed as EC 220.127.116.11.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Oncogene Protein p55(v-myc): Transforming protein coded by myc oncogenes. The v-myc protein has been found in several replication-defective avian retrovirus isolates which induce a broad spectrum of malignancies.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Oncogene Proteins, Fusion: The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.Cell Line, Tumor: A cell line derived from cultured tumor cells.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Proto-Oncogenes: Normal cellular genes homologous to viral oncogenes. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc.Gene Amplification: A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.Breast Neoplasms: Tumors or cancer of the human BREAST.Oncogene Protein pp60(v-src): A tyrosine-specific protein kinase encoded by the v-src oncogene of ROUS SARCOMA VIRUS. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its N-terminal glycine.Oncogene Protein gp140(v-fms): Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).Genes, myc: Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.Oncogene Proteins v-myb: Transforming proteins coded by myb oncogenes. Transformation of cells by v-myb in conjunction with v-ets is seen in the avian E26 leukemia virus.Proto-Oncogene Proteins c-myc: Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Proto-Oncogene Proteins p21(ras): Cellular proteins encoded by the H-ras, K-ras and N-ras genes. The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. Elevated levels of p21 c-ras have been associated with neoplasia. This enzyme was formerly listed as EC 18.104.22.168.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Oncogene Protein v-maf: An oncogene protein that was originally isolated from a spontaneous musculo-aponeurotic FIBROSARCOMA in CHICKEN and shown to be the transforming gene of the avian retrovirus AS42. It is a basic leucine zipper TRANSCRIPTION FACTOR and the founding member of the MAF TRANSCRIPTION FACTORS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Retroviridae Proteins, Oncogenic: Retroviral proteins that have the ability to transform cells. They can induce sarcomas, leukemias, lymphomas, and mammary carcinomas. Not all retroviral proteins are oncogenic.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Oncogene Proteins v-raf: A family of transforming proteins isolated from retroviruses such as MOUSE SARCOMA VIRUSES. They are viral-derived members of the raf-kinase family of serine-theonine kinases.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Cell Line, Transformed: Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cell Transformation, Viral: An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Oncogene Proteins v-abl: Transforming proteins encoded by the abl oncogenes. Oncogenic transformation of c-abl to v-abl occurs by insertional activation that results in deletions of specific N-terminal amino acids.Oncogene Proteins v-sis: Transforming proteins coded by sis oncogenes. Transformation of cells by v-sis is related to its interaction with the PDGF receptor and also its ability to alter other transcription factors.Oncogene Protein v-crk: A signal transducing adaptor protein that is encoded by the crk ONCOGENE from TYPE C AVIAN RETROVIRUSES. It contains SRC HOMOLOGY DOMAINS and is closely related to its cellular homolog, PROTO-ONCOGENE PROTEIN C-CRK.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Oncogene Proteins v-erbA: Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.3T3 Cells: Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.QuinazolinesTranscription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.ras Proteins: Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 22.214.171.124.Mammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Protein-Tyrosine Kinases: Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Oncogene Proteins v-rel: Transforming proteins coded by rel oncogenes. The v-rel protein competes with rel-related proteins and probably transforms cells by acting as a dominant negative version of c-rel. This results in the induction of a broad range of leukemias and lymphomas.DNA, Neoplasm: DNA present in neoplastic tissue.Phosphatidylinositol 3-Kinases: Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.Proto-Oncogene Proteins c-akt: A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Receptor Protein-Tyrosine Kinases: A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Retroviridae: Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Translocation, Genetic: A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Oncogene Proteins v-fos: Transforming proteins coded by fos oncogenes. These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses which induce osteogenic sarcomas in mice. The FBJ-MSV v-fos gene encodes a p55-kDa protein and the FBR-MSV v-fos gene encodes a p75-kDa fusion protein.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Oncogene Protein p65(gag-jun): Transforming protein coded by jun oncogenes (GENES, JUN). This is a gag-onc fusion protein of about 65 kDa derived from avian sarcoma virus. v-jun lacks a negative regulatory domain that regulates transcription in c-jun.RNA, Small Interfering: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.Avian leukosis virus: The type species of ALPHARETROVIRUS producing latent or manifest lymphoid leukosis in fowl.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Oncogene Proteins v-mos: Transforming proteins coded by mos oncogenes. The v-mos proteins were originally isolated from the Moloney murine sarcoma virus (Mo-MSV).Genes, src: Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20.Mucin-4: A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.Alpharetrovirus: A genus of the family RETROVIRIDAE with type C morphology, that causes malignant and other diseases in wild birds and domestic fowl.NIH 3T3 Cells: A continuous cell line of high contact-inhibition established from NIH Swiss mouse embryo cultures. The cells are useful for DNA transfection and transformation studies. (From ATCC [Internet]. Virginia: American Type Culture Collection; c2002 [cited 2002 Sept 26]. Available from http://www.atcc.org/)Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Oncogene Fusion: The GENETIC RECOMBINATION of the parts of two or more GENES, including an ONCOGENE as at least one of the fusion partners. Such gene fusions are often detected in neoplastic cells and are transcribed into ONCOGENE FUSION PROTEINS.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Swiercz JM, Kuner R, Offermanns S (2004). "Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB ... Oncogene. 23 (30): 5131-7. doi:10.1038/sj.onc.1207650. PMID 15184888. ... Vikis HG, Li W, He Z, Guan KL (Nov 2000). "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand ... Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras ...
The ErbB family consists of four plasma membrane-bound receptor tyrosine kinases. One of which is erbB-2, and the other members ... "Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene". Science. 230 ( ... 4:4483 Receptor, erbB-2 at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ... Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 ( ...
... receptor, erbb-3 MeSH D12.776.543.750.060.468 -- receptor, igf type 1 MeSH D12.776.543.750.060.484 -- receptor, insulin MeSH ... receptor, fibroblast growth factor, type 4 MeSH D12.776.543.750.060.124 -- proto-oncogene proteins c-kit MeSH D12.776.543.750. ... receptor, epidermal growth factor MeSH D12.776.543.750.750.400.350 -- receptor, erbb-2 MeSH D12.776.543.750.750.400.360 -- ... receptor, erbb-3 MeSH D12.776.543.750.750.400.370 -- receptors, fibroblast growth factor MeSH D12.776.543.750.750.400.370.500 ...
1994). "Characterization of mouse non-receptor tyrosine kinase gene, HYL". Oncogene. 9 (11): 3371-4. PMID 7936664. Maruyama K, ... 2002). "Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function ... Yamashita, H; Avraham S; Jiang S; Dikic I; Avraham H (May 1999). "The Csk homologous kinase associates with TrkA receptors and ... 1999). "The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells". J. Biol. ...
... a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control". Oncogene ... ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene. MIG6 is a Cytoplasmic protein ... "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1". Benzinger, Anne; Muster Nemone; Koch Heike B; Yates John R; Hermeking ... 2003). "Feedback inhibition by RALT controls signal output by the ErbB network". Oncogene. 22 (27): 4221-4234. doi:10.1038/sj. ...
1994). "Characterization of mouse non-receptor tyrosine kinase gene, HYL.". Oncogene 9 (11): 3371-4. PMID 7936664. CS1 ... 2002). "Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function ... B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 126.96.36.199, 3.4.21/22/23/24, ... 1999). "The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells.". J. Biol ...
... a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase". Oncogene. 18 (17): 2681-9. doi:10.1038/sj.onc. ... Receptor tyrosine-protein kinase erbB-4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor ... ErbB-3 and ErbB-4". Oncogene. 15 (23): 2841-8. doi:10.1038/sj.onc.1201458. PMID 9419975. Check date values in: ,year= / ,date= ... Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced ...
Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound ... "Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene". Science. 230 ( ... ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ... Epidermal growth factor receptor family Epidermal growth factor receptor Receptor tyrosine-kinases GRCh38: Ensembl release 89: ...
... is derived from the name of a viral oncogene to which these receptors are homologous: erythroblastic leukemia viral oncogene. ... The ErbB protein family consists of 4 members ErbB-1, also named epidermal growth factor receptor (EGFR) ErbB-2, also named ... Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are ... The figure below shows the tridimensional structure of the ErbB family proteins, using the pdb files 1NQL (ErbB-1), 1S78 (ErbB- ...
... supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB ... Oncogene. 28 (29): 2634-42. doi:10.1038/onc.2009.126. PMID 19483726. Sanga S, Broom BM, Cristini V, Edgerton ME (2009). "Gene ... It has been suggested that GATA-3 is regulated in CD4+ T cells at a transcriptional level through the IL-4 receptor, as well as ... Marine J, Winoto A (Aug 1991). "The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements ...
"Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609-18. doi: ... "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609-18. doi: ... Xia X, Cheng A, Lessor T, Zhang Y, Hamburger AW (May 2001). "Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb ... Xia X, Cheng A, Lessor T, Zhang Y, Hamburger AW (May 2001). "Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb ...
Recent insights into the activation of EGF/ErbB receptors". Mol. Cell. 12 (3): 541-52. doi:10.1016/S1097-2765(03)00350-2. PMID ... Oncogene. 18 (39): 5363-72. doi:10.1038/sj.onc.1202909. PMID 10498890. Guo J, Kleeff J, Zhao Y, Li J, Giese T, Esposito I, ... It is a TGFβ type 1 receptor antagonist. It blocks TGFβ1 and activin associating with the receptor, blocking access to SMAD2. ... "Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation". J. Biol ...
Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI (August 2007). "ErbB receptors: from oncogenes to targeted ... The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor ... The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members ... Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE (June 1999). "ErbB receptor-induced activation of stat transcription ...
androgen receptor binding. • identical protein binding. • enzyme binding. • ubiquitin protein ligase binding. • importin-alpha ... Xia X, Cheng A, Lessor T, Zhang Y, Hamburger AW (May 2001). "Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb ... Cells respond to stress in the form of DNA damage, activated oncogenes, or sub-par growing conditions, and can enter a ... androgen receptor signaling pathway. • chromatin remodeling. • negative regulation of smoothened signaling pathway. • negative ...
Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Molecular Systems Biology ... Oncogene, vol. 26, no. 22, 2007, pp. 3227-3239., doi:10.1038/sj.onc.1210414. 4. Yao, Guang, et al. "A Bistable Rb-E2F Switch ... Receptor-linked tyrosine kinases such as the epidermal growth factor receptor (EGFR) are activated by extracellular ligands. ... The signal starts when a signaling molecule binds to the receptor on the cell surface and ends when the DNA in the nucleus ...
Abl gene Androgen receptor Apoptosis-antagonizing transcription factor ARID4A Aryl hydrocarbon receptor BRCA1 BRF1 C-jun C-Raf ... Xia X, Cheng A, Lessor T, Zhang Y, Hamburger AW (May 2001). "Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb ... Cells in response to stress in the form of DNA damage, activated oncogenes, or sub-par growing conditions can enter a ... Simone C, Bagella L, Bellan C, Giordano A (June 2002). "Physical interaction between pRb and cdk9/cyclinT2 complex". Oncogene. ...
... odorant receptor - olfaction - olfactory receptor neuron - Oligopeptide - oncogene - oncogene protein - oncogene proteins V-abl ... epidermal growth factor receptor - Epidiorite - epigenetics - Epinephrine - equine gonadotropin - erbA gene - erbB gene - erbB- ... proto-oncogene - proto-oncogene proteins - proto-oncogene protein C-kit - proto-oncogene proteins c-abl - proto-oncogene ... fusion oncogene protein - G protein - G protein-coupled receptor - G3P - GABA - GABA receptor - GABA-A receptor - gag-onc ...
Schulze WX, Deng L, Mann M. "Phosphotyrosine interactome of the ErbB-receptor kinase family". Molecular Systems Biology. 1: ... Oncogene. 9 (6): 1661-8. PMID 8183561. Pandey A, Duan H, Di Fiore PP, Dixit VM (Sep 1995). "The Ret receptor protein tyrosine ... EPH receptor A2, ETV6, Epidermal growth factor receptor, Erythropoietin receptor, FRS2, Fas ligand, GAB1, GAB2, Glycoprotein ... Olayioye MA, Graus-Porta D, Beerli RR, Rohrer J, Gay B, Hynes NE (Sep 1998). "ErbB-1 and ErbB-2 acquire distinct signaling ...
... oncogene proteins v-erbb MeSH D12.776.624.664.520.750.887 - oncogene proteins v-fos MeSH D12.776.624.664.520.750.900 - oncogene ... receptor, erbb-3 MeSH D12.776.624.664.700.800 - receptor, macrophage colony-stimulating factor MeSH D12.776.624.664.700.830 - ... oncogene proteins v-erba MeSH D12.776.964.700.750.883 - oncogene proteins v-erbb MeSH D12.776.964.700.750.887 - oncogene ... oncogene proteins v-erba MeSH D12.776.964.775.750.883 - oncogene proteins v-erbb MeSH D12.776.964.775.750.887 - oncogene ...
... has been shown to interact with: ErbB-2 receptor tyrosine kinase MK5 HSPA9 HSPA8, JAK2, and RASA1 ENSG00000103423 GRCh38 ... In neuromuscular junctions, only the short isoform clusters acetylcholine receptors for efficient synaptic transmission. The ... 2002). "Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer". Oncogene. 21 (32 ... Oncogene. 29 (8): 1155-66. doi:10.1038/onc.2009.413. PMID 19935715. Elwi, AN; Lee, B; Meijndert, HC; Braun, JE; Kim, SW (August ...
Rozanov DV, Hahn-Dantona E, Strickland DK, Strongin AY (2004). "The low density lipoprotein receptor-related protein LRP is ... Oncogene. 22 (30): 4617-26. doi:10.1038/sj.onc.1206542. PMID 12879005. ... 55 (2): 89-98. doi:10.1002/pros.10194. PMID 12661033. Takino T, Koshikawa N, Miyamori H (2003). "Cleavage of metastasis ... 1354 (2): 159-70. doi:10.1016/s0167-4781(97)00120-6. PMID 9396633. Terp GE, Christensen IT, Jørgensen FS (2000). "Structural ...
... has been shown to interact with: EPH receptor B1, Insulin receptor, PTK2, RET proto-oncogene, and Rnd1 Model organisms ... "Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3". The Journal ... This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ... Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the GRB7 gene. The ...
Jin Cho S, La M, Ahn JK, Meadows GG, Joe CO (May 2001). "Tob-mediated cross-talk between MARCKS phosphorylation and ErbB-2 ... Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes ... "Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling". Mechanisms of Development. 120 (5): 629- ... Jin Cho S, La M, Ahn JK, Meadows GG, Joe CO (May 2001). "Tob-mediated cross-talk between MARCKS phosphorylation and ErbB-2 ...
... erbb MeSH G14.340.024.340.383.500.791.295.300 --- genes, erbb-1 MeSH G14.340.024.340.383.500.791.295.305 --- genes, erbb-2 MeSH ... t-cell receptor MeSH G14.340.024.340.585.050 --- genes, t-cell receptor alpha MeSH G14.340.024.340.585.080 --- genes, t-cell ... oncogenes MeSH G14.340.024.340.383.500.791 --- proto-oncogenes MeSH G14.340.024.340.383.500.791.100 --- genes, abl MeSH G14.340 ... t-cell receptor delta MeSH G14.340.024.340.585.400 --- genes, t-cell receptor gamma MeSH G14.340.024.340.605 --- genes, viral ...
RTK class I (EGF receptor family) (ErbB family) RTK class II (Insulin receptor family) RTK class III (PDGF receptor family) RTK ... Robinson DR, Wu YM, Lin SF (November 2000). "The protein tyrosine kinase family of the human genome". Oncogene. 19 (49): 5548- ... NGF receptor family) RTK class VIII (HGF receptor family) RTK class IX (Eph receptor family) RTK class X (AXL receptor family) ... RYK receptor family) RTK class XIII (DDR receptor family) RTK class XIV (RET receptor family) RTK class XV (ROS receptor family ...
Receptor tyrosine kinase. *ErbB: HER1/EGFR (Cetuximab. *Panitumumab). *HER2/neu (Trastuzumab. *Trastuzumab emtansine) ... "Oncogene. 27 (34): 4702-11. doi:10.1038/onc.2008.109. PMC 2748240. PMID 18408761.. ... It is mainly used to treat cases of NSCLC that harbour mutations in the epidermal growth factor receptor (EGFR) gene. ... Afatinib covalently binds to cysteine number 797 of the epidermal growth factor receptor (EGFR) via a Michael addition (IC50 = ...
Human Epidermal growth factor Receptor type 2 (HER2) is over expressed in 20.0-30.0% of breast cancers and is currently ... Oncogene 19: 6102-6114. * Van der Geer P, Hunter T, Lindberg RA (1994) Receptor protein-tyrosine kinases and their signal ... Yamauchi H, Stearns V, Hayes DF (2001) When is a tumor marker ready for prime time? A case study of c-erbB-2 as a predictive ... Fehm T, Gebauer G, Jäger W (2002) Clinical utility of serial serum c-erbB-2 determinations in the follow-up of breast cancer ...
The HER2 protooncogene encodes a receptor tyrosine kinase, p185HER2. The overexpression of p185HER2 has been associated with a ... Proto-Oncogene Proteins / biosynthesis * Proto-Oncogene Proteins / immunology* * Receptor, ErbB-2 * Tumor Cells, Cultured ... The HER2 protooncogene encodes a receptor tyrosine kinase, p185HER2. The overexpression of p185HER2 has been associated with a ... but had no effect on the growth of colon or gastric adenocarcinomas expressing increased levels of this receptor. The most ...
2011 Apr 14;13(2):R43. doi: 10.1186/bcr2865. Research Support, Non-U.S. Govt ... EGFR, epidermal growth factor receptor; HER2, proto-oncogene c-ErbB-2; HER3, receptor tyrosine kinase erbB-3. (B) T47-DPBI ... The active form of an upstream regulator of Akt, proto-oncogene c-ErbB-2/receptor tyrosine kinase erbB-3 (HER2/HER3) receptor ... Estrogen receptor β expression decreases Akt signaling in breast cancer cells. (A) T47-DERβ cells were treated for 1 day up to ...
T1 - C-erbB-2 oncogene product expression depends on tumour type and is related to oestrogen receptor and lymph node status in ... C-erbB-2 oncogene product expression depends on tumour type and is related to oestrogen receptor and lymph node status in human ... C-erbB-2 oncogene product expression depends on tumour type and is related to oestrogen receptor and lymph node status in human ... C-erbB-2 oncogene product expression depends on tumour type and is related to oestrogen receptor and lymph node status in human ...
Proto-Oncogene Proteins c-myc / physiology * Receptor, ErbB-2 / genetics * Receptor, ErbB-2 / immunology* ...
Precleared lysates were transferred to new tubes, and 4 (for BT474) or 10 μl (for HN5) of anti-c-neu Ab-3 (Oncogene Research ... With the exception of ErbB-3, which acts as a noncatalytic partner to other erbB family members, the type I receptors have ... Inhibition of Receptor Autophosphorylation in Cells. The ability of GW2016 to inhibit the activity of EGFR and ErbB-2 in intact ... Receptors were immunoprecipitated using either EGFR or ErbB-2 antibodies and blotted for phosphotyrosine content. Treatment ...
Buy our Recombinant human ErbB 2 (mutated R896 C) protein. Ab207994 is an active protein fragment produced in Baculovirus ... Tyrosine kinase-type cell surface receptor HER2. *V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 ... Recombinant human ErbB 2 (mutated R896 C) protein. See all ErbB 2 proteins and peptides. ... Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ...
Tyrosine kinase-type cell surface receptor HER2 antibody. *V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 ( ... neuro/glioblastoma derived oncogene homolog) antibody. *V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 ... Humtsoe JO et al. ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth. Oncogene 35:1554-64 ( ... Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ...
Proto-Oncogene Proteins c-akt / metabolism. Receptor, erbB-2 / metabolism*. Tumor Cells, Cultured. ... Epidermal growth factor receptor (EGFR, ErbB, or HER) family members are essential regulators of cell growth, development and ... EC 188.8.131.52/Receptor, erbB-2; EC 184.108.40.206/Proto-Oncogene Proteins c-akt; EC 220.127.116.11/Mitogen-Activated Protein Kinases; ... Upon receptor dimerization allosteric interactions regulate the kinase activity in HER-family members that in turn lead to the ...
Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 ... neuroblastoma/glioblastoma derived oncogene homolog; NGL; NGLTKR1; p185erbB2; Proto-oncogene c-ErbB-2; ... ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF ... neuro/glioblastoma derived oncogene homolog); v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/ ...
... termed proto-oncogenes, of transforming genes transduced or activated by transforming retroviruses have been implicated in the ... Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature 1984; 307: 521-7.PubMed ... The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocytic growth factor, CSF-1. Cell 1985; 41 ... growth factor and hormone receptors (e.g., erbB , fms , and erbA ); (3) intracellular tyrosine (e.g.,src[161) and ...
ELK1, member of ETS oncogene family. [none]. ERBB2. receptor tyrosine-protein kinase erbB-2. CD340, HER-2, HER-2/neu, HER2, MLN ... MDM2 proto-oncogene, E3 ubiquitin protein ligase. ACTFS, HDMX, hdm2. MET. MET proto-oncogene, receptor tyrosine kinase; ... epidermal growth factor receptor. ERBB, ERBB1, HER1, PIG61, mENA. EIF4EBP1. eukaryotic translation initiation factor 4E-binding ... Cbl proto-oncogene B, E3 ubiquitin protein ligase. Cbl-b, RNF56. CBLC. Cbl proto-oncogene C, E3 ubiquitin protein ligase. CBL-3 ...
Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2. Oncogene. 2003;22:1546-56.CrossRefPubMed ... Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression. ... Nagasawa T. CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4. J Mol Med (Berl). 2014;92(5):433-9.CrossRefGoogle Scholar ... The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors. Cancer ...
Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian ... cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway transmembrane receptor protein ... neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; Proto-oncogene c-ErbB-2; ... ErbB-3 class receptor binding. phosphatidylinositol-4,5-bisphosphate 3-kinase activity. protein heterodimerization activity. ...
Oncogenes and proto-oncogenes are DNA sequences that encode factors that drive the cell cycle and include growth factors, their ... On the other hand, studies of the erb-B-2 oncoprotein have indicated that the expression of erb-B-2 is common in human head and ... Receptors for epidermal growth factor and steroid hormones in primary laryngeal tumors. Cancer 1991;67:1347-51. ... Conversely, anti-oncogene or tumor suppressor gene protein products retard or inhibit the cell cycle or activate pathways that ...
Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis. Proc Natl Acad Sci U S A 2000; 97: 3444-9. ... Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. ... Loss of expression of transforming growth factor β type II receptor correlates with high tumour grade in human breast in-situ ... Effect of Conditional Knockout of the Type II TGF-β Receptor Gene in Mammary Epithelia on Mammary Gland Development and ...
Swiercz JM, Kuner R, Offermanns S (2004). "Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB ... Oncogene. 23 (30): 5131-7. doi:10.1038/sj.onc.1207650. PMID 15184888. ... Vikis HG, Li W, He Z, Guan KL (Nov 2000). "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand ... Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras ...
V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) * Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) ...
V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) * Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) ... anti-Solute Carrier Family 31 (Copper Transporters), Member 2 Antikörper * anti-Solute Carrier Family 31 (Copper Transporters ... anti-Solute Carrier Family 36 (Proton/amino Acid Symporter), Member 2 Antikörper ...
Oncogene 24 , 7599-7607 Rights & permissionsfor article The c-Src tyrosine kinase associates with the catalytic domain of ErbB- ... Oncogene 21 , 1800-1811 Rights & permissionsfor article Use of signal specific receptor tyrosine kinase oncoproteins reveals ... Rights & permissionsfor article The human ,i,met,/i, oncogene is related to the tyrosine kinase oncogenes . Opens in a new ... The human met oncogene is related to the tyrosine kinase oncogenes *Michael Dean ...
HER-2) (Tyr1248) Monoclonal Antibody from Invitrogen for Western Blot, Immunofluorescence and Immunohistochemistry applications ... Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian ... neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; p185neu; Proto-oncogene c-ErbB-2; ... RNA polymerase I core binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor ...
Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 ... neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; Proto-oncogene c-ErbB-2; ... downstream of receptor, with protein tyrosine kinase activity; transmembrane receptor activity; transmembrane receptor protein ... Molecular Function: ATP binding; ErbB-3 class receptor binding; growth factor binding; identical protein binding; ...
Preliminary study of oncogene expressions in endometrial cancers-aberrant estrogen receptor gene and erbB-2- Eur J Gynecol. ( ... Uterine Endometrial Cancer / Uterine Leiomyoma / Ovaian Cancer / Sex Steroid Receptors / Oncogenes / Tyrosine kinase C / ... Mutations of epidermal growth factor receptor and erbB-2 mRNAs were detected in endometrial cancer, which with mutated ER might ... progesterone could not regulate the estrogen-induced oncogene expressons.. Expression of progesterone receptor form M mRNA ...
Aberrant regulation of the erythroblastosis oncogene B (ErbB) family of receptor tyrosine kinases (RTKs) and their ligands is ... ERBB3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3. Aliases: HER3, LCCS2, ErbB-3, c-erbB3, erbB3-S, MDA-BF- ... Inactive ERBB receptors cooperate with reactive oxygen species to suppress cancer progression.. Mol Ther. 2013; 21(11):1996- ... The ERBB receptors are a family of heterodimerization partners capable of driving transformation and metastasis. While the ...
Peles E, Yarden Y. Neu and its ligands: from an oncogene to neural factors. Bioassay 1993; 15:815-824.Google Scholar ... An immunological approach reveals biological differences between the two NDF/heregulin receptors, erbB-3 and erbB-4. J Biol ... Neu differentiation factor activation of erbB-3 and erbB-4 is cell specific and displays a differential requirement for erbB-2 ... EGF binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK- ...
Epidermal growthHER2ERBB2EGFROverexpressionAntibodyEncodesHomologBreast cancerHER3Cell surfaceErbB3Tumor CellsAntibodiesPathwaysImmunohistochemistryExtracellular domainInhibitionGlioblastomaChimeric antigen receptorSignalingHumanAntigenLigand inducedGenesMammary tumorFunction as an oncogeneErbB4Poor prognosisApoptosisProgressionAndrogen receptorCytoplasmic tailChemokine
- Human Epidermal growth factor Receptor type 2 (HER2) is over expressed in 20.0-30.0% of breast cancers and is currently evaluated histopathologically. (clinmedjournals.org)
- Human Epidermal growth factor Receptor type 2 (HER2) is a glycoprotein of 185 kDa that comprises an Extracellular ligand-binding Domain (ECD), a transmembrane domain, and an intracellular domain [ 1 , 2 ]. (clinmedjournals.org)
- Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2. (springer.com)
- The following antibody was used in this experiment: Phospho-ErbB2 (HER-2) (Tyr1248) Monoclonal Antibody (PN2A) from Thermo Fisher Scientific, catalog # MA5-11367, RRID AB_10980292. (thermofisher.com)
- Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (wikipedia.org)
- ERBB2, a known proto-oncogene, is located at the long arm of human chromosome 17 (17q12). (wikipedia.org)
- The vector of anti-ErbB2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human ErbB2. (creative-biolabs.com)
- ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. (hzmihoo.com)
- Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. (hzmihoo.com)
- ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays a key role in development, cell proliferation and differentiation. (hzmihoo.com)
- Past discoveries include ErbB2, initially identified by his lab as an amplified erbB related gene in a primary human breast cancer. (mssm.edu)
- While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members (2). (cellsignal.com)
- It is also called ERBB2, CD340 or proto-oncogene Neu. (rockland-inc.com)
- We investigated the recruitment of receptor complexes in two c-erbB2-overexpressing breast carcinoma cell lines, SK-BR-3 and BT474, after ligand binding and its effects on intracellular signal transduction and cell cycle regulation. (uni-regensburg.de)
- RESULTS: After stimulation with EGF BT474, but not SK-BR-3, cells formed EGFR/c-erbB2 receptor complexes. (uni-regensburg.de)
- Neither EGF nor heregulin (HRG) induced c-erbB2/c-erbB3 receptor complexes in BT474. (uni-regensburg.de)
- CONCLUSIONS: We show that in the presence of identical amounts of c-erbB2 receptors, the ligand-induced cellular response differs significantly. (uni-regensburg.de)
- Overall, there is strong evidence that c-erbB2 receptor overexpression in breast cancer cells is an insufficient marker to determine cellular response in terms of cell proliferation. (uni-regensburg.de)
- ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2) is a Protein Coding gene. (genecards.org)
- Transactivation of erbB2 by short and long isoforms of leptin receptors. (springermedizin.de)
- Microarray mRNA expression profiles of sensitive and resistant cell lines showed that although ERBB1 receptor or ligand levels did not associate with cetuximab sensitivity, high levels of ERBB2 ( P = 0.036) and amphiregulin ( P = 0.026) predicted sensitivity to lapatinib. (pnas.org)
- 1-4 Its biological effects are mediated by a set of tyrosine kinase receptors (ErbB2, ErbB3, and ErbB4) that dimerize on ligand binding, leading to phosphorylation and downstream signaling. (ahajournals.org)
- The epidermal growth factor receptor (EGFR) and ErbB-2 transmembrane tyrosine kinases are currently being targeted by various mechanisms in the treatment of cancer. (aacrjournals.org)
- GW2016 is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC 50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 n m , respectively. (aacrjournals.org)
- This report describes the efficacy in cell growth assays of GW2016 on human tumor cell lines overexpressing either EGFR or ErbB-2: HN5 (head and neck), A-431 (vulva), BT474 (breast), CaLu-3 (lung), and N87 (gastric). (aacrjournals.org)
- Inhibition of EGFR and ErbB-2 receptor autophosphorylation and phosphorylation of the downstream modulator, AKT, was verified by Western blot analysis in the BT474 and HN5 cell lines. (aacrjournals.org)
- Together, these results indicate that GW2016 achieves excellent potency on tumor cells with selectivity for tumor versus normal cells and suggest that GW2016 has value as a therapy for patients with tumors overexpressing either EGFR or ErbB-2. (aacrjournals.org)
- The EGFR 2 and ErbB-2 are members of the type I receptor tyrosine kinase family and have been investigated as potential targets for cancer therapy because of their overexpression in a variety of neoplastic tissues ( 1 ). (aacrjournals.org)
- EGFR and ErbB-2 are known to signal through the Ras pathway, stimulating cell division ( 3 ), and through the PI3K pathway, resulting in cell growth and survival ( 1 ). (aacrjournals.org)
- Because these effects on cell growth and survival are dependent on the catalytic activity of EGFR and ErbB-2, it is believed that inhibition of this activity could provide a therapeutic opportunity for patients with tumors expressing elevated levels of EGFR and ErbB-2. (aacrjournals.org)
- Recent efforts to design small molecule inhibitors of EGFR have generated encouraging preclinical and clinical results ( 2-8 ). (aacrjournals.org)
- We have reported previously the discovery of a number of small molecule, dual EGFR/ErbB-2, tyrosine kinase inhibitors with activity in preclinical tumor models ( 9 , 10 ). (aacrjournals.org)
- GW2016 is a potent inhibitor of EGFR and ErbB-2 tyrosine kinase catalytic activity and is selective for EGFR and ErbB-2 versus other proliferative kinases. (aacrjournals.org)
- Cross-talk with growth factor receptors, such as epidermal growth factor receptor (EGFR) family, has been postulated as a potential mechanism to activate AR in recurrent prostate cancer. (aacrjournals.org)
- We used two independent methods, expression of intracellular single-chain antibody against HER-2 and treatment with a novel dual EGFR/HER-2 kinase inhibitor GW572016 (lapatinib). (aacrjournals.org)
- GW572016 was more potent in its ability to inhibit PSA expression and AR recruitment and histone acetylation than the EGFR-selective kinase inhibitor ZD1839 (gefitinib), consistent with the HER-2 kinase playing the major role in AR regulation. (aacrjournals.org)
- The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, such as EGFR and HER-2/neu (ErbB-2), has been postulated to modulate AR transcriptional function. (aacrjournals.org)
- ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR. (wikipedia.org)
- This gene encodes amember of the epidermal growth factor receptor (EGFR) family of receptortyrosine kinases. (creativebiomart.net)
- It has also been reported that epidermal growth factor receptor (EGFR) is necessary for HCMV-mediated signaling and entry (X. Wang, S. M. Huong, M. L. Chiu, N. Raab-Traub, and E. E. Huang, Nature 424:456-461, 2003). (asm.org)
- Integrins are known to signal synergistically with growth factor receptors, and this coordination was recently reported for EGFR and β3 integrins in the context of HCMV entry (X. Wang, D. Y. Huang, S. M. Huong, and E. S. Huang, Nat. (asm.org)
- These results suggest that specific integrin heterodimers either act alone as the primary entry receptors or interact in conjunction with an additional receptor(s), other than EGFR, to facilitate virus entry. (asm.org)
- Therapies that target the EGF receptor (EGFR), such as gefitinib (IRESSA), are effective in a subset of patients with advanced non-small cell lung cancer (NSCLC). (pnas.org)
- Two gefitinib-sensitive NSCLC cell lines with endogenous distinct activating EGFR mutations (L858R and Del747-749), frequently observed in NSCLC patients who respond to gefitinib, also use ErbB-3 to couple to PI3K. (pnas.org)
- Down-regulation of ErbB-3 by means of short hairpin RNA leads to decreased phospho-Akt levels in the gefitinib-sensitive NSCLC cell lines, Calu-3 (WT EGFR) and H3255 (L858R EGFR), but has no effect on Akt activation in the gefitinib-resistant cell lines, A549 and H522. (pnas.org)
- We conclude that ErbB-3 is used to couple EGFR to the PI3K/Akt pathway in gefitinib-sensitive NSCLC cell lines harboring WT and mutant EGFRs. (pnas.org)
- The EGF receptor (EGFR) is one such target, because it is known to promote growth of cells and function as an oncogene and is expressed in up to 80-90% of non-small cell lung cancer (NSCLC) (reviewed in ref. 3 ). (pnas.org)
- The EGFR is a member of four proteins in the ErbB family of receptor tyrosine kinases. (pnas.org)
- FUNCTION: Ligand of the EGF receptor/EGFR and ERBB4. (genome.jp)
- C-erbB-2/HER-2 is a member of the EGFR family. (mybiosource.com)
- Sensitivity analysis identified ErbB3 as the key node in response to ligands that can bind either ErbB3 or EGFR (epidermal growth factor receptor). (sciencemag.org)
- The ErbB-2 proto-oncogene, also called Neu, EGFR-2 or HER-2, is a member of the transmembrane receptor tyrosine kinase family, which also includes EGF receptor and EGFR-3 (HER-3 or ErbB-3). (activemotif.com)
- Effective assessment of low times MET amplification in pleural effusion after epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) acquired resistance: Cases report. (bireme.br)
- RATIONALE: The mechanism of the first-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) acquired resistance included T790M mutation, cellular-mesenchymal to epithelial transition factor (MET) or EGFR amplification, PIK3CA mutation, and transformation to small cell lung cancer. (bireme.br)
- Here, we reported 2 lung adenocarcinoma cases with MET amplification in pleural effusion rapidly responded to crizotinib after EGFR-TKIs acquired resistance. (bireme.br)
- BACKGROUND: Receptors belonging to the epidermal growth factor receptor (EGFR) family transfer extracellular signals by homotypic and heterotypic receptor interaction and cross-activation. (uni-regensburg.de)
- A gene on chromosome 12q13 that encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases which binds and is activated by neuregulins and NTAK. (thefreedictionary.com)
- Competitive-differential polymerase chain reaction for gene dosage estimation of erbB-1 (egfr), erbB-2, and erbB-3 oncogenes. (thefreedictionary.com)
- 80,Since this transmembrane receptor has homology to other family members (epidermal growth factor receptor [EGFR], erbB-3 , and erbB-4), clinical tests must be specific for erbB-2 (as opposed to cross-reacting with homologous family members) and specific enough to detect amplification (increased gene copy number) or protein overexpression above the normal level. (thefreedictionary.com)
- EGFR, also named as ERBB1, is a cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. (ptglab.com)
- The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). (genecards.org)
- Overexpression of Gab1 increased Bcl-2/BAX ratio to promote cell growth via PI3K/AKT. (springer.com)
- Other groups have reported that overexpression of HER-2 induced androgen-independent growth of prostate cancer cells and activated AR transcriptional function through the mitogen-activated protein kinase (MAPK) pathway or the Akt pathway ( 5 - 7 ). (aacrjournals.org)
- However, published data on the frequency of overexpression of HER-2 in primary prostate cancer specimens are conflicting ( 8 - 10 ), and the in vivo role of HER-2 in prostate cancer and AR function remains unclear. (aacrjournals.org)
- By immunoperoxidase test, this antibody stained specifically the tumor cell membrane in frozen tissue sections of breast and ovarian tumors indicating overexpression of the C-erbB-2 product. (iospress.com)
- Overexpression of ERBB4 JM-a CYT-1 and CYT-2 isoforms in transgenic mice reveal isoform-specific roles in mammary gland development and carcinogenesis. (yale.edu)
- V. B. Wali, M. Gilmore-Hebert, R. Mamillapalli, J. W. Haskins, K. J. Kurppa, K. Elenius, C. J. Booth, D. F. Stern, Overexpression of ERBB4 JM-a CYT-1 and CYT-2 isoforms in transgenic mice reveal isoform-specific roles in mammary gland development and carcinogenesis. (yale.edu)
- Both Neu and the EGF receptor stimulate proliferation of breast cancer cells, and overexpression of these two proteins correlates with progression of human breast cancer and poor patient prognosis ( 28 , 31 , 47 ). (asm.org)
- Overexpression of ErbB-2 results in autophosphorylation and induction of signaling pathways involving Ras and c-Src ( 27 , 43 , 51 ). (asm.org)
- Overexpression of the erbB-2 proto-oncogene in canine osteosarcoma cell lines and tumors. (cdc.gov)
- Given the importance of erbB-2 in human breast cancer, the finding of erbB-2 overexpression in canine OSA may be important in further understanding the pathogenesis and possible therapies of OSA. (cdc.gov)
- COX-2 overexpression was correlated with a differentiated histologic type, deep invasion, and positive lymph node metastasis. (aacrjournals.org)
- A multivariate analysis demonstrated a significantly poor outcome for the concomitant overexpression of COX-2 in patients with Smad4-reduced tumors. (aacrjournals.org)
- These results support the possibility that signal transduction via HER-2 and the TGF-β/Smad system may be implicated in COX-2 expression and that the reduction of Smad4 may be, in part, of causal significance in the TGF-β-initiated overexpression of COX-2, which is associated with a poor prognosis for patients with gastric cancer. (aacrjournals.org)
- Overexpression and Amplification of the Met/HGF Receptor Gene During the Progression of Colorectal Cancer" Clinical Cancer Research 1:147-154 (Feb. 1995). (patentgenius.com)
- Although, ErbB-2 does not have any known high-affinity ligands, its kinase activity can be activated without ligand by either overexpression or heteroassociation with other members of the ErbB family. (activemotif.com)
- Amplification of the ErbB-2 gene and overexpression of its product has been detected in almost 40% of primary human breast tumors, which correlates with poor prognosis in node positive breast cancer. (activemotif.com)
- ErbB-2 overexpression is also observed in ovarian, gastric, salivary and non-small cell lung carcinomas. (activemotif.com)
- Epidermal growth factor receptor overexpression in human cancer can be effectively targeted by drugs acting as specific inhibitors of the receptor, like erlotinib, gefitinib, cetuximab and panitumumab. (bireme.br)
- The amplification and/or overexpression of the HER-2/neu oncogene and its encoded receptor protein are increasingly used for prognostication and prediction of therapeutic response to Herceptin in breast cancer. (nih.gov)
- 0.0001), and both HER-2/neu gene amplification and protein overexpression were strongly associated with tumor grade, estrogen receptor status, and progesterone receptor status. (nih.gov)
- We have downregulated cell surface expression of individual erbB receptors via intracellular antibody expression prior to analyzing ligand induced signaling. (springer.com)
- Expression of intracellular HER-2 antibody scFv-5R and treatment with GW572016 inhibited HER-2 signaling. (aacrjournals.org)
- Inactivation of AR by antibody, ribozyme, or RNA interference results in inhibition of proliferation or tumorigenicity of hormone refractory prostate cancer cells ( 1 , 2 ). (aacrjournals.org)
- Therefore, in this study, we investigated the effect of inhibiting HER-2 using an intracellular antibody and a novel kinase inhibitor GW572016. (aacrjournals.org)
- Flowcytometric analysis performed using various cancer cell lines revealed that this Monoclonal antibody exhibited high binding affinity with BT474 and SKBR3 cells whichoverexpresses C-erbB-2. (iospress.com)
- All these results well correlated with those obtained using a control antibody ICR12, an anti-C-erbB-2 antibody. (iospress.com)
- These studies clearly indicate that Monoclonal antibody CIBCgp185 might prove useful to identify tumors with over expression of C-erbB-2 which are often associated with poor prognosis and early recurrence. (iospress.com)
- Monoclonal anti-c-erbB-4 antibody can be used to study the role of erbB-4 and its interaction with other erbB family members as well as the cellular and molecular mechanisms underlying tumor growth. (sigmaaldrich.com)
- Monoclonal anti-c-erbB-4 antibody can be used in immunoprecipitation (4-8 μg/test) using RIPA lysate of cultured CB4 cells (CHO cell line transfected with erbB-4). (sigmaaldrich.com)
- Store at 2 to 8 degree C. Antibody is stable for 24 months. (mybiosource.com)
- The Y877 kit contains phospho-ErbB-2 antibody that recognizes ErbB-2 only when phosphorylated at Tyr877, while the Y1248 kit provides a phospho-antibody that recognizes ErbB-2 only when phosphorylated at Tyr1248. (activemotif.com)
- The FACE ErbB-2 (Y877) Kit contains a phospho-ErbB-2 antibody that was raised in rabbit against a synthetic phospho-peptide corresponding to residues surrounding phosphorylated Tyr877 of human ErbB-2 and recognizes ErbB-2 only when phosphorylated at Tyr877. (activemotif.com)
- Its sequence shows that the c-erb-B-2 gene encodes a possible receptor protein and allows an analysis of the similarity of the protein to the EGF receptor and the neu product. (nih.gov)
- The latter transcript presumably encodes only the extracellular domain of the putative receptor. (nih.gov)
- This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. (thermofisher.com)
- The C-erbB-2 proto-oncogene encodes the production of a cell surface receptor protein, with tyrosine kinase activity. (iospress.com)
- The neu (c- erbB-2 ) proto-oncogene encodes a tyrosine kinase receptor that is overexpressed in 20 to 30% of human breast tumors. (asm.org)
- The neu (c- erbB-2 , HER-2 ) proto-oncogene encodes a receptor tyrosine kinase that is a member of a growth factor receptor family, which includes the epidermal growth factor (EGF) receptor (ErbB-1), ErbB-3, and ErbB-4. (asm.org)
- The erbB oncogene encodes an altered form of the epidermal growth factor (EGF) receptor that lacks the extracellular ligand binding domain. (umassmed.edu)
- The neu oncogene encodes an epidermal growth factor receptor-related protein," Nature 319:226-230, 1986. (patents.com)
- HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. (prospecbio.com)
- Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NFkappaB) pathway. (yale.edu)
- A significant proportion of colorectal cancer (CRC) patients are resistant to anti-ERBB1 [avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, receptor for EGF] monoclonal antibodies (Mabs). (pnas.org)
- Monoclonal antibodies against the epidermal growth factor receptor, ERBB1 [avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, receptor for EGF], including in particular cetuximab, are now commonly used in colorectal cancer (CRC) treatment ( 1 ⇓ - 3 ). (pnas.org)
- Furthermore, decreased expression of the type II receptor (TβRII) may be an early event in human breast tumorigenesis because women with breast biopsies containing epithelial hyperplasia lacking atypia and a reduced level of TβRII immunostaining cells had a 3.41-fold increased risk for developing invasive breast cancer compared with women with similar lesions having high levels of TβRII immunostaining (9) . (aacrjournals.org)
- Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. (semanticscholar.org)
- A total of 116 specimens with early breast cancer, defined as tumors of â‰¤2 cm in size and clinically negative axilla, were studied immunohistochemically for ER, PgR, and c-erbB-2 expression. (ebscohost.com)
- Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. (wikipedia.org)
- The HER-2/Neu/ErbB-2 receptor tyrosine kinase is a major human oncogene and a validated therapeutic target in breast cancer. (yale.edu)
- This receptor is the target for two drugs in use for breast cancer treatment, Herceptin/Trastuzumab and Tykerb/Lapatinib. (yale.edu)
- In primary human breast tumors, a splice variant of ErbB-2 encoding a similar ECD deletion which can also transform Rat-1 fibroblasts has been detected, suggesting that such activating mutants of ErbB-2 may similarly have a critical role in human breast cancer induction and progression ( 62 ). (asm.org)
- Amplification of the Neu/c-erbB-2 receptor tyrosine kinase has been implicated as an important event in the genesis of human breast cancer. (asm.org)
- Decreased expression of C-erbB-2 and CXCR4 in breast cancer after primary chemotherapy. (biomedsearch.com)
- c-erbB-1) and epidermal growth factor receptor (HER)2 (c-erbB-2) can be detected in the serum of breast cancer patients. (biomedcentral.com)
- The erbB (human epidermal growth factor receptor [HER]/neu 1 to 4) receptors are a family of four known receptors localized on the cell membrane of most tumours, including breast cancer. (biomedcentral.com)
- 1997). "Association of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells. (wikipedia.org)
- Because of this, ErbB-2 is one of the major drug targets for breast cancer and other cancer treatments. (activemotif.com)
- ESR1 promoter hypermethylation is observed in both estrogen receptor ER(+) and ER(−) breast cancer specimens at widely varying rates-from 0% to 100%-although these studies often stratify specimens according to multiple characteristics such as hormone receptor status ( 12 - 18 ). (aacrjournals.org)
- The suppression of estrogen receptor in these ER(−) cell lines is lifted after treatment with the demethylating agent 5-azacytidine ( 19 ), and previous findings suggest a correlation between ESR1 promoter hypermethylation and suppression of message and protein levels in breast cancer ( 15 , 17 ). (aacrjournals.org)
- Recent studies show that that ESR1 promoter hypermethylation outdid hormone receptor status as a predictor of clinical response to the selective estrogen receptor modulator tamoxifen in women with invasive breast cancer ( 20 ). (aacrjournals.org)
- Canonical ErbB-2 isoform and ErbB-2 variant c located in the nucleus drive triple negative breast cancer growth. (amedeo.com)
- The oxytocin receptor signalling system and breast cancer: a critical review. (amedeo.com)
- Targeting disseminated estrogen-receptor-positive breast cancer cells in bone marrow. (amedeo.com)
- Clinical studies in breast cancer with novel ErbB inhibitors are currently underway. (ahajournals.org)
- Trastuzumab's targeted therapy has become a stronghold for human epidermal growth factor receptor 2 positive breast cancer patients. (jcancer.org)
- Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. (abcam.com)
- The ability of HCMV to enter a wide variety of cell types suggests that HCMV utilizes multiple receptors and/or a widely distributed cell surface receptor for entry. (asm.org)
- It plays a crucial role as a cell surface receptor for neuregulins. (sigmaaldrich.com)
- The report provides comprehensive information on the Receptor Tyrosine Protein Kinase ERBB 4 (Tyrosine Kinase Type Cell Surface Receptor HER4 or Proto Oncogene Like Protein c ErbB 4 or p180erbB4 or HER4 or ERBB4 or EC 18.104.22.168), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (reportsnreports.com)
- Additionally, the report provides an overview of key players involved in Receptor Tyrosine Protein Kinase ERBB 4 (Tyrosine Kinase Type Cell Surface Receptor HER4 or Proto Oncogene Like Protein c ErbB 4 or p180erbB4 or HER4 or ERBB4 or EC 22.214.171.124) targeted therapeutics development and features dormant and discontinued projects. (reportsnreports.com)
- Upon ligand binding, heterodimers form between ErbB3 and other ErbB proteins, and ErbB3 is phosphorylated on tyrosine residues by the activated ErbB kinase (1,2). (cellsignal.com)
- Research studies have demonstrated that in tumor development, ErbB3 may function as an oncogenic unit together with other ErbB members (e.g. (cellsignal.com)
- Thus, investigators view inhibiting interaction between ErbB3 and ErbB tyrosine kinases as a novel strategy for anti-tumor therapy. (cellsignal.com)
- NRG-1 can bind to 2 receptors: ErbB3 and ErbB4. (ahajournals.org)
- Increased HGF/MET signaling might compensate the inhibitory effect of epidermal growth factor receptor inhibitors in skin as well as tumor cells, leading to less severe skin rash and decreased efficacy of the anti-tumor therapy, rendering the plasma concentration of HGF a candidate for predictive biomarkers. (bireme.br)
- In the present work we have screened a variety of different tumor cell lines for p185HER2 expression using both enzyme-linked immunosorbent and fluorescence-activated cell sorting assays employing murine monoclonal antibodies directed against the extracellular domain of the receptor. (nih.gov)
- Some monoclonal antibodies directed against the extracellular domain of p185HER2 inhibited growth in monolayer culture of breast and ovarian tumor cell lines overexpressing p185HER2, but had no effect on the growth of colon or gastric adenocarcinomas expressing increased levels of this receptor. (nih.gov)
- Genes encoding single-chain Fv domains (scFvs) directed to the extracellular portion of these receptors were derived from hybridoma cells producing the corresponding monoclonal antibodies. (springer.com)
- The very low levels of expression of C-erbB-2 by normal tissues makes this receptor a potential target for diagnosis and therapy with Monoclonal antibodies raised against its extracellular domain. (iospress.com)
- Each FACE ErbB-2 Kit provides 96 rxns each of 2 antibodies that enable you to monitor and compare the levels of both phosphorylated and total ErbB-2. (activemotif.com)
- Circulating Antibodies Against C-myc Oncogene Product In Sera Of Colorectal Cancer Patients," Int. J. Cancer 46: 35-38, 1990. (patents.com)
- Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. (google.com)
- Anne Goriely ( [email protected]) suggested adding the MRAS (RRAS3) -SHOC2.PPP1CA pathways that activate RAF kinase and ERF, an ETS-family protein that inhibits ERK1 (aka MAPK3) and 2 (MAPK1). (cancer.gov)
- Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. (wikipedia.org)
- Proteomic analysis showed that stromal secretion of the growth factor hepatocyte growth factor (HGF) resulted in activation of the HGF receptor MET, reactivation of the MAPK and PI3K/AKT pathways, and immediate resistance to RAF inhibition. (pubmedcentralcanada.ca)
- The concentration of HGF was also significantly inversely correlated with severity of rash (p-value = 0.00124).High levels of HGF lead to increased signaling via its receptor MET, which can activate numerous pathways which are normally also activated by epidermal growth factor receptor. (bireme.br)
- The interaction between the programmed cell death receptor 1 (PD-1) and its ligand is one of the pathways recently reported to be a potential target in EMPD. (mdedge.com)
- The expressions of C-erbB-2, CXCR4 and ER-α were measured by immunohistochemistry (IHC) on full tissue sections and on tissue microarrays (TMAs). (biomedsearch.com)
- We tested whether ESR1 promoter hypermethylation and/or estrogen receptor (ER) protein expression by immunohistochemistry predicted persistent atypia in 18 women who were treated with tamoxifen for 12 months and in 16 untreated controls. (aacrjournals.org)
- The inhibition of estrogen receptor (ER) α action with the ER antagonist tamoxifen is an established treatment in the majority of breast cancers. (nih.gov)
- This HER-2 inhibition led to impairment of AR-mediated functions, such as androgen-stimulated growth and the induction of endogenous prostate-specific antigen (PSA) mRNA and protein. (aacrjournals.org)
- These results show that HER-2 signaling is required for optimal transcriptional activity of AR in prostate cancer cells and suggest that HER-2 inhibition may provide a novel strategy to disrupt AR function in prostate cancer. (aacrjournals.org)
- Our results show that HER-2 inhibition leads to impairment of AR transcriptional function at the level of recruitment of AR to the androgen responsive enhancer on chromatin. (aacrjournals.org)
- Tumor suppression depended on residues in the C-terminal domain of plexin B1 which mediate receptor GAP activity, and also correlated with AKT inhibition. (pubmedcentralcanada.ca)
- Chimeric antigen receptor-engineered NK-92 cells: An off-the-shelf cellular therapeutic for targeted elimination of cancer cells and induction of protective anti-tumor immunity. (georg-speyer-haus.de)
- Chimeric antigen receptor-engineered cytokine-induced killer cells overcome treatment resistance of pre-B-cell acute lymphoblastic leukemia and enhance survival. (georg-speyer-haus.de)
- The chimeric antigen receptor T (CAR-T) cell therapy is a newly developed adoptive antitumor treatment. (springermedizin.de)
- Chmielewski M, Hombach AA, Abken H. Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma. (springermedizin.de)
- Chimeric antigen receptor T cell therapy targeting CD19-positive leukemia and lymphoma in the context of stem cell transplantation. (springermedizin.de)
- Whereas ErbB-2 is generally thought to be orphaned from a high-affinity ligand, it participates in signaling by heterodimerization with ligand-bound members of the type I receptor family. (aacrjournals.org)
- Analysis of signaling emanating from this receptor family is complicated by the extensive crosstalk which occurs among the individual receptors. (springer.com)
- Fanti WJ, Johnson DE, Williams LT. Signaling by receptor tyrosine kinases. (springer.com)
- The Broad Spectrum Receptor Tyrosine Kinase Inhibitor Dovitinib Suppresses Growth of BRAF Mutant Melanoma Cells in Combination with Other Signaling Pathway Inhibitors. (yale.edu)
- The mitogenic activity of the ErbB family, induced by ligand addition, is initiated through the formation of heterodimeric and homodimeric receptor signaling complexes ( 49 ). (asm.org)
- We examined the involvement of two growth factor-signaling systems, HER-2 and transforming growth factor (TGF)-β, in the induction of COX-2 in human gastric cancer tissue. (aacrjournals.org)
- However, whether HER-2 signaling is involved in the regulation of COX-2 in gastric cancer remains unknown. (aacrjournals.org)
- The lab has also discovered and characterized genes for a number of other growth factor signaling molecules activated as oncogenes in human malignancies. (mssm.edu)
- The PKC inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal Btk activity (8). (cellsignal.com)
- MM-121, a previously unidentified anticancer therapeutic designed using a systems approach, promises to benefit patients with combinatorial, ligand-induced activation of the ErbB signaling network that are not effectively treated by current therapies targeting overexpressed or mutated oncogenes. (sciencemag.org)
- We studied molecules involved in epidermal growth factor receptor signaling which are quantifiable in plasma, with the aim of identifying biomarkers for the severity of rash. (bireme.br)
- Programmed cell death receptor 1 (PD-1) signaling can serve as a potential target in EMPD. (mdedge.com)
- Untangling the ErbB signaling network. (springermedizin.de)
- Since the discovery that neuregulin-1 (NRG-1)/ErbB signaling is indispensable in cardiac development, evidence has shown that this system also plays a crucial role in the adult heart. (ahajournals.org)
- In vivo studies, however, did not uniformly reinforce a role for apoptosis in the development of cardiomyopathy induced by impaired NRG-1/ErbB signaling. (ahajournals.org)
- On the other hand, pharmacological activation of ErbB signaling is likely an unrecognized and beneficial effect of currently used drugs in heart failure and a promising therapeutic approach to prevent or reverse myocardial dysfunction. (ahajournals.org)
- NRG-1/ErbB signaling. (ahajournals.org)
- C-erbB-2 oncogene product expression depends on tumour type and is related to oestrogen receptor and lymph node status in human breast carcinoma. (qub.ac.uk)
- The cellular homologues, termed proto-oncogenes, of transforming genes transduced or activated by transforming retroviruses have been implicated in the etiology of a number of human cancers. (springer.com)
- Reddy EP, Reynolds RK, Santos E, Barbacid M. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. (springer.com)
- Complete nucleotide sequence of the T24 human bladder carcinoma oncogene and its normal homologue. (springer.com)
- Nishikura K, ar-Rushdi A, Erikson J, Watt R, Rovera G, Croce C. Differential expression of the normal and of the translocated human c-myc oncogenes in B cells. (springer.com)
- Alitalo K, Schwab M, Lin C, Varmus H, Bishop J. Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. (springer.com)
- Persson H, Leder P. Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene. (springer.com)
- Recombinant human p185/HER-2. (thermofisher.com)
- MA5-11367 targets Phospho-HER-2 pTyr1248 in IF, IHC, and WB applications and shows reactivity with Human and Rat samples. (thermofisher.com)
- Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. (semanticscholar.org)
- Pathological expression of human ErbB-2 protein, also known as HER-2, is common in many types of cancer. (semanticscholar.org)
- From a human genomic library, we obtained six v-erbB-related DNA clones. (semanticscholar.org)
- Epidermal growth factor (EGF) receptor and erbB-2, two receptors whose aberrant expression is frequently involved in human cancer, were chosen as targets. (springer.com)
- Epidermal growth factor-related peptides and their receptors in human malignancies. (springer.com)
- Thus, oncogenicity of ErbB-2 in human epithelia may not rely on the existence of a specific ligand but rather on its ability to act as a coreceptor for multiple stroma-derived growth factors. (uptodate.com)
- Human cytomegalovirus (HCMV), a member of the Herpesviridae family of viruses, is an opportunistic pathogen that causes significant disease in immunocompromised individuals, including AIDS patients, organ transplant recipients, and neonates ( 2 , 21 ). (asm.org)
- The status of the erbB-2 (human epidermal growth factor receptor 2/neu) proto-oncogene in canine osteosarcoma (OSA) has not been reported previously. (cdc.gov)
- (13) demonstrated that HER-2 stimulates COX-2 transcription via the Ras pathway in cultured human mammary epithelial cells. (aacrjournals.org)
- Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. (springermedizin.de)
- Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR chain. (springermedizin.de)
- BACKGROUND: Biological molecular markers such as proto-oncogene erbB-2 (HER-2/neu, c-erbB-2), the CXC chemokine receptor 4 (CXCR4), estrogen receptor (ER), Proliferating Cell Nuclear Antigen (PCNA), DNA topoisomerase II (topo II), P-glycoprotein (P-gp) and glutathione S-transferase (GST) were observed for changes after administration of neochemotherapy and whether these protein expression changes were correlated with response to chemotherapy. (biomedsearch.com)
- EGF receptor endocytosis is achieved by a constitutive pathway and a ligand-induced pathway (for review see Sorkin and Waters, 1993 ). (rupress.org)
- It has been shown recently that kinase-deficient receptors fail to undergo ligand-induced sequestration into coated pits ( Lamaze and Schmid, 1995 ) and that, as a result, kinasedeficient receptors are not internalized via coated vesicles. (rupress.org)
- 7-13 In addition, there is evidence that altered genes may cooperate with other oncogenes, such as ras, to generate cells with a growth advantage for tumor progression, a multifunctional process associated(14)with cutaneous carcinogenesis as well. (oralcancerfoundation.org)
- some DNA polymorphism of estrogen and progesterone receptor genes may contribute to invasion and metastasis of gynecologic cancers. (nii.ac.jp)
- The importance of AP-2 genes is highlighted by the embryonic lethal phenotypes of mice lacking AP-2α, β, or γ ( 5 -8 ). (aacrjournals.org)
- Results from a screen for genes regulated by AP-2α indicate that AP-2 might play a central role at the checkpoint proliferation/differentiation by repressing differentiation-specific markers and inducing proliferation-specific genes during development ( 9 ). (aacrjournals.org)
- It has therefore been suggested that AP-2 genes might be causally involved in the tumorigenesis of the breast. (aacrjournals.org)
- Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression. (springer.com)
- To experimentally address the potential involvement of AP-2 in mammary gland tumorigenesis, we generated mice overexpressing AP-2γ by transgenesis using the mouse mammary tumor virus-long terminal repeat as the transgene-driving promoter unit. (aacrjournals.org)
- lthough c-erbB-2 expression is, in general terms, an ominous prognostic indicator in breast carcinomas, there are suggestions that lack of this oncogene, when combined with analogous lack of estrogen (ER negative) and progesterone receptors (PgR negative)â€"â€œtriple-negative phenotypeâ€ , is linked with an equally poor prognosis. (ebscohost.com)
- Estrogen receptor beta 2 is associated with poor prognosis in estrogen receptor alpha-negative breast carcinoma. (ebscohost.com)
- In addition, several studies have linked AP-2γ expression with the expression of the receptor tyrosine kinase ErbB-2 (encoded by the HER-2/c- neu proto-oncogene), representing a clinical marker for a poor prognosis in breast carcinoma ( 12 ). (aacrjournals.org)
- Transcription Factor AP-2γ Stimulates Proliferation and Apoptosis and Impairs Differentiation in a Transgenic Model11Grants from Deutsche Forschungsgemeinschaft (Scho 503) and HGF (SGF01SF9808) to H.S. supported this work. (aacrjournals.org)
- There the effects of AP-2γ on proliferation and apoptosis were even more pronounced, and differentiation was impaired, too, as revealed by the absence of androgen receptor immunoreactivity. (aacrjournals.org)
- Additionally, PI3K/AKT/Bcl-2/BAX axis was involved in Gab1-induced CS progression, indicating Gab1 might act as a new target for the treatment of CS patients. (springer.com)
- There is a high prevalence of dysplastic change among(1,2,22) these lesions, approaching 80-90%, and progression to invasive carcinoma is high. (oralcancerfoundation.org)
- The androgen receptor (AR) likely plays a key role in this progression and in the continued survival and proliferation of prostate cancer cells in the low androgen environment. (aacrjournals.org)
- Current evidence implicates the androgen receptor (AR) as playing a key role in the hormone refractory progression of prostate cancer. (aacrjournals.org)
- The expression of cyclooxygenase-2 (COX-2) is known to be involved in gastric carcinogenesis and tumor progression, but little is known about the mechanisms responsible for the up-regulation of COX-2. (aacrjournals.org)
- Nagasawa T. CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4. (springer.com)
- CXCR4 is the principal chemokine receptor expressed on breast carcinoma cells with possible but undefined roles in various steps of metastatic cell diffusion and homing to secondary sites ( 12 , 13 ). (aacrjournals.org)