A genus of parasitic nematodes whose organisms live and breed in skin and subcutaneous tissues. Onchocercal microfilariae may also be found in the urine, blood, or sputum.
A species of parasitic nematodes widely distributed throughout central Africa and also found in northern South America, southern Mexico, and Guatemala. Its intermediate host and vector is the blackfly or buffalo gnat.
Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.
Several species of the genus Simulium (family Simuliidae) that act as intermediate hosts (vectors) for the parasitic disease ONCHOCERCIASIS.
A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
The prelarval stage of Filarioidea in the blood and other tissues of mammals and birds. They are removed from these hosts by blood-sucking insects in which they metamorphose into mature larvae.
Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.
Pharmacological agents destructive to nematodes in the superfamily Filarioidea.
Deoxyribonucleic acid that makes up the genetic material of helminths.
Infection with nematodes of the genus MANSONELLA. Symptoms include pruritus, headache, and articular swelling.
Skin diseases caused by ARTHROPODS; HELMINTHS; or other parasites.
Immunoglobulins produced in a response to HELMINTH ANTIGENS.
A genus of parasitic nematodes found throughout the rain-forest areas of the Sudan and the basin of the Congo. L. loa inhabits the subcutaneous tissues, which it traverses freely.
A republic in central Africa lying east of CHAD and the CENTRAL AFRICAN REPUBLIC and west of NIGERIA. The capital is Yaounde.
Proteins found in any species of helminth.
A superfamily of nematodes of the suborder SPIRURINA. Its organisms possess a filiform body and a mouth surrounded by papillae.
A genus of bacteria comprised of a heterogenous group of gram-negative small rods and coccoid forms associated with arthropods. (From Bergey's Manual of Systematic Bacteriology, vol 1, 1984)
An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.
Drugs used to treat or prevent parasitic infections.
Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
A genus of parasitic nematodes whose organisms are distributed in Central and South America. Characteristics include a smooth cuticle and an enlarged anterior end.
A filarial nematode parasite of mammalian blood with the vector being a tick or small fly.
A republic in western Africa, lying between GHANA on its west and BENIN on its east. Its capital is Lome.
A parasitic infection caused by the nematode Loa loa. The vector in the transmission of this infection is the horsefly (Tabanus) or the deerfly or mango fly (Chrysops). The larvae may be seen just beneath the skin or passing through the conjunctiva. Eye lesions are not uncommon. The disease is generally mild and painless.
A genus of filarial nematodes. Various immature species have been found to infect the eyes or subcutaneous tissue in humans.
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
Inflammation of the cornea.
Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.
A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.
A republic in western Africa, south of GUINEA and east of COTE D'IVOIRE. Its capital is Monrovia.
A species of parasitic nematode causing Malayan filariasis and having a distribution centering roughly on the Malay peninsula. The life cycle of B. malayi is similar to that of WUCHERERIA BANCROFTI, except that in most areas the principal mosquito vectors belong to the genus Mansonia.
Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.
A republic in western Africa, south of SENEGAL and MALI, east of GUINEA-BISSAU. Its capital is Conakry.
A plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. They are trees and shrubs having an elongated conelike floral axis with fragrant flowers that have six tepals (sepals and petals that are not distinctly different) and many spirally arranged stamens.
A white threadlike worm which causes elephantiasis, lymphangitis, and chyluria by interfering with the lymphatic circulation. The microfilaria are found in the circulating blood and are carried by mosquitoes.
A genus of parasitic nematodes found in the peritoneal cavity of wild or domestic cattle or equines.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
The geographical area of Africa comprising BENIN; BURKINA FASO; COTE D'IVOIRE; GAMBIA; GHANA; GUINEA; GUINEA-BISSAU; LIBERIA; MALI; MAURITANIA; NIGER; NIGERIA; SENEGAL; SIERRA LEONE; and TOGO.
Inflammation of the choroid in which the sensory retina becomes edematous and opaque. The inflammatory cells and exudate may burst through the sensory retina to cloud the vitreous body.
The reduction or regulation of the population of noxious, destructive, or dangerous insects through chemical, biological, or other means.
Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.
A twisting in the intestine (INTESTINES) that can cause INTESTINAL OBSTRUCTION.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A republic in central Africa, east of the REPUBLIC OF THE CONGO, south of the CENTRAL AFRICAN REPUBLIC and north of ANGOLA and ZAMBIA. The capital is Kinshasa.
An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.
A serine protease found in the azurophil granules of NEUTROPHILS. It has an enzyme specificity similar to that of chymotrypsin C.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.

Pathogenesis of onchocercal keratitis (River blindness). (1/97)

Onchocerciasis is a major cause of blindness. Although the World Health Organization has been successful in reducing onchocerciasis as a public health problem in parts of West Africa, there remain an estimated 17 million people infected with Onchocerca volvulus, the parasite that causes this disease. Ocular pathology can be manifested in any part of the eye, although disease manifestations are frequently characterized as either posterior or anterior eye disease. This review focuses on onchocerca-mediated keratitis that results from an inflammatory response in the anterior portion of the eye and summarizes what is currently known about human disease. This review also describes studies with experimental models that have been established to determine the immunological mechanisms underlying interstitial keratitis. The pathogenesis of keratitis is thought to be due to the host inflammatory response to degenerating parasites in the eye; therefore, the primary clinical symptoms of onchocercal keratitis (corneal opacification and neovascularization) are induced after injection of soluble O. volvulus antigens into the corneal stroma. Experimental approaches have demonstrated an essential role for sensitized T helper cells and shown that cytokines can regulate the severity of keratitis by controlling recruitment of inflammatory cells into the cornea. Chemokines are also important in inflammatory cell recruitment to the cornea, and their role in onchocerciasis is being examined. Further understanding of the molecular basis of the development of onchocercal keratitis may lead to novel approaches to immunologically based intervention.  (+info)

A new technique for the determination of microfilarial densities in onchocerciasis. (2/97)

Precise measurement of the parasite load in helminthic infections makes it possible to correlate morbidity, the individual response to treatment, and the best control methods. A membrane filtration technique was recently developed for quantifying Wuchereria bancrofti microfilaraemia. The present paper describes its application to onchocerciasis in a study on 107 patients in northern Togo. The technique is cheap and simple to apply under field conditions, and is extremely efficient at recovering microfilariae from skin snips.  (+info)

Macrofilaricidal activity of tetracycline against the filarial nematode Onchocerca ochengi: elimination of Wolbachia precedes worm death and suggests a dependent relationship. (3/97)

Filarial nematodes are important and widespread parasites of animals and humans. We have been using the African bovine parasite Onchocerca ochengi as a chemotherapeutic model for O. volvulus, the causal organism of 'river blindness' in humans, for which there is no safe and effective drug lethal to adult worms. Here we report that the antibiotic, oxytetracycline is macrofilaricidal against O. ochengi. In a controlled trial in Cameroon, all adult worms (as well as microfilariae) were killed, and O. ochengi intradermal nodules resolved, by nine months' post-treatment in cattle treated intermittently for six months. Adult worms removed from concurrent controls remained fully viable and reproductively active. By serial electron-microscopic examination, the macrofilaricidal effects were related to the elimination of intracellular micro-organisms, initially abundant. Analysis of a fragment of the 16S rRNA gene from the O. ochengi micro-organisms confirmed them to be Wolbachia organisms of the order Rickettsiales, and showed that the sequence differed in only one nucleotide in 858 from the homologous sequence of the Wolbachia organisms of O. volvulus. These data are, to our knowledge, the first to show that antibiotic therapy can be lethal to adult filariae. They suggest that tetracycline therapy is likely to be macrofilaricidal against O. volvulus infections in humans and, since similar Wolbachia organisms occur in a number of other filarial nematodes, against those infections too. In that the elimination of Wolbachia preceded the resolution of the filarial infections, they suggest that in O. ochengi at least, the Wolbachia organisms play an essential role in the biology and metabolism of the filarial worm.  (+info)

Onchocerca ochengi transmission dynamics and the correlation of O. ochengi microfilaria density in cattle with the transmission potential. (4/97)

The intensity of natural transmission of Onchocerca ochengi and Onchocerco volvulus by anthropo-boophilic Simulium damnosum s.l. was studied longitudinally in two cattle watering sites of a cattle ranch within a predominantly cattle populated area of the Guinea savanna of Cameroon and related to cattle O. ochengi skin microfilaria abundance. During the 12 months study period, a total of 4696 flies was individually dissected to examine the monthly transmission potential (MTP) of O. ochengi and O. volvulus. The estimated Simulium damnosum s.l. annual biting rates (ABR) on human baits were 47529 flies at the bank of the Vina "du sud" river. The ABR at the lake, which was situated at about 2 km upland from the perennial river, was 8579. The monthly parous rate was highly correlated with monthly biting rate. The annual transmission potentials (ATP) of O. ochengi were calculated to be 7732 and 1669 at the riverbank and the lake, respectively. Transmission occurred mainly in the dry season, peaking in the months of January to mid-March when dermal microfilaria density in the animals was also the highest. The O. ochengi microfilaria uptake by the fly vectors was host microfilaria density-dependent. The MTP of O. ochengi was positively correlated with dermal microfilaria density. The mean number of microfilariae per fly taken up during a blood meal was high during the dry season as was the mean number of infective larvae per fly but declined significantly with the onset of the early rains. A similar seasonality of transmission was also observed for O. volvulus that was concurrently transmitted by the same vector flies, but its ATP was comparatively much lower: 1332 infective larvae per man per year at the riverbank and 107 around the lake. The population dynamics of cattle microfilariae therefore plays an important role in the regulation of O. ochengi transmission.  (+info)

Down-regulated lymphoproliferation coincides with parasite maturation and with the collapse of both gamma interferon and interleukin-4 responses in a bovine model of onchocerciasis. (5/97)

Onchocerciasis is a debilitating parasitic infection caused by the filarial nematode Onchocerca volvulus. Infections are chronic, and persistence of the parasites for several years argues for highly adapted mechanisms of immune evasion. Due to the restricted host repertoire of O. volvulus, we have used the cattle parasite Onchocerca ochengi to investigate the nature of immunomodulation underpinning these long-term infections. Cattle were infected with a single inoculation of 350 infective-stage larvae under laboratory conditions (n = 6). Intradermal nodules containing immature adult worms were detected from 110 days postinfection, and microfilariae in skin were detected from day 280 postinfection. Parasite-specific responses during early infection were nonpolarized with respect to the major Th cytokines (interleukin-4 [IL-4], IL-2, and gamma interferon [IFN-gamma]) produced by antigen-stimulated peripheral blood mononuclear cells (PBMC) or serum antibody isotypes. Antigen-induced proliferation of PBMC peaked shortly after exposure and remained high during the prepatent infection. As the parasites matured and animals developed patent infections, there was a profound down-regulation of lymphoproliferation, accompanied by sharp falls in the expression of both IL-4 and IFN-gamma and a gradual decline in IL-2. Levels of immunoglobulin G2 (IgG2) fell, while those of IgG1 remained high. We conclude that neither a classical Th2 response nor a simple Th1-to-Th2 switch is sufficient to explain the immunomodulation associated with patent Onchocerca infections. Instead, there is an initial Th0 response, which matures into a response with some, but not all of the features of a Th2 response. The natural host-parasite relationship of O. ochengi in cattle may be useful as both a descriptive and predictive tool to test more refined models of immunomodulation in onchocerciasis.  (+info)

Expression and secretion of a larval-specific chitinase (family 18 glycosyl hydrolase) by the infective stages of the parasitic nematode, Onchocerca volvulus. (6/97)

A recently reported chitinase gene, expressed in the infective, third-stage (L3) larvae of the human filarial parasite Onchocerca volvulus, belongs to the family 18 glycosyl hydrolases and has been designated Ov-chi-1. The gene product of Ov-chi-1 is chitinolytic. Allosamidin ablates activity of the native enzyme in a dose-dependent manner but did not significantly inhibit the moulting of L3 larvae. Mono-specific antibodies were used to characterize Ov-CHI-1 as a 60-kDa protein expressed almost exclusively in L3 stages. Immunoelectron microscopy showed that Ov-CHI-1 expression is initiated in late L2 larvae and increases markedly in infective, L3 larvae. It is synthesized exclusively in the glandular esophagus and stored within discrete secretory granules. Secretion occurs through de-granulation during post-infective development, and the primary route of transport appears to be via the pseudo-coelom. An orthologue of Ov-chi-1 was detected in Caenorhabditis elegans by BLAST analysis. It is constitutively expressed at a low level and is overexpressed in dauer larvae and embryonated eggs. It is chitinolytic. We conclude that Ov-CHI-1 is a highly stage-specific enzyme that may have a role in infectivity of the parasite, aiding escape from the vector or participating in early post-infective migration and/or development. The identification of an orthologue in C. elegans opens the way for further studies into the biological function(s) of this intriguing parasite product.  (+info)

Community-based ivermectin therapy for onchocerciasis: comparison of three methods of dose assessment. (7/97)

A new method of assessment based on mid-upper arm circumference (MUAC) is described for dosage adjustment for community-based ivermectin distribution. We studied 878 subjects eligible for ivermectin dosing in Awhum, Nigeria. In a previous preliminary study of 40 persons, MUAC (in cm) correlated with weight (kg) in the first 20 male (r = 0.97, r2 = 0.95, P < 0.0001) and the first 20 female subjects (r = 0.94, r2 = 0.88, P < 0.0001). We therefore studied the use of height, physical appearance, and MUAC for calculating the dose of ivermectin. The MUAC-based schedule underdosed only 4.1% of the population. The methods based on height underdosed 3.3% and 21.1%, and assignment based on physical appearance underdosed 10.2% of the population studied. This MUAC-based method (13-15 cm, 0.5 tablet; 16-20 cm, 1.0 tablet; 21-27 cm, 1.5 tablets; > or = 28 cm, 2.0 tablets) is more convenient and corresponds closely to dosing by weight. An adaptation of this method with reference to other prevalent tropical diseases and their respective drugs is therefore advocated.  (+info)

Sensitive and specific serodiagnosis of onchocerciasis with recombinant hybrid proteins. (8/97)

Onchocerciasis remains a major health hazard in many tropical countries. However, the existing tools for diagnosis of the disease have limitations, particularly regarding the detection of low level or early infections. To design an optimized reagent, we exploited the high antibody reactivity of patient sera against the Onchocerca volvulus proteins Ov20 and Ov33, which have been described as highly sensitive and specific immunodiagnostic reagents for producing hybrid proteins. The construct OvH2 was composed of Ov20 fused to Ov33, while OvH3 consisted of the C-terminus of Ov20 linked to Ov33. When these constructs were tested with sera from patients with onchocerciasis and control sera, OvH2 showed a sensitivity of 98.5% and a specificity of 97.7% and OvH3 showed a sensitivity of 98.5% and a specificity of 95.35%. All non-responders were from Ecuador. These results surpass those of existing single recombinant antigens, suggesting that our hybrid proteins combined the sensitivity of the two parent proteins. Tests based on OvH2 should prove suitable for monitoring onchocerciasis control programs and individual diagnosis.  (+info)

Onchocerca lupi infection is reported primarily in symptomatic dogs. We aimed to determine the infection in dogs from areas of Greece and Portugal with reported cases. Of 107 dogs, 9 (8%) were skin snip-positive for the parasite. DNA sequences of parasites in specimens from distinct dog populations differed genetically from thoses in GenBank.
Hassan HK, Bolcen S, Kubofcik J, Nutman TB, Eberhard ML, Middleton K, Wekesa, J.W., Ruedas, G., Nelson, K., Dubielzig, R., De Lombaert, M., Silverman, B., Schorling, J., Adler, P., Unnasch, T., and Beeler, S. (2015). Isolation of Onchocerca lupi in dogs and black flies, California, USA. Emerg Infect Dis [Internet]. 2015 May 5. https://dx.doi.org/10.3201/eid2105.142011 ...
Gentaur molecular products has all kinds of products like :search , ICL \ anti-Bovine Albumin Whole Serum, Host Rabbit \ RAL-10 for more molecular products just contact us
Buy Lupi Hcg injections online from premiumrxdrugs.com at low price for Infertility treatments for women who have been trying to get pregnant
Nezn m lupi p epadl pobo ku IPB ve vehlov ulici v des t m stsk sti. Ukraden pen ze, jejich hodnotu policie odhadla na v ce ne milion korun, se mu v ak nepoda ilo odn st. Na cest z banky mu v ta ce vybuchla rozbu ka s erven m barvivem, kter je znehodnotila, proto ta ku s pen zi odhodil. Lupi v bance, ve kter nabyl v tu dobu dn klient, hrozil bombou. Pyrotechnici zjistili, e jde poze o dr ty z po ta e, potvrdila na m st Iva Knolov z pra sk policejn spr vy.
TY - JOUR. T1 - Experimental ocular onchocerciasis in cynomolgus monkeys. II. Chorioretinitis elicited by intravitreal Onchocerca lienalis microfilariae. AU - Semba, Richard David. AU - Donnelly, J. J.. AU - Rockey, J. H.. AU - Lok, J. B.. AU - Sakla, A. A.. AU - Taylor, H. R.. PY - 1988. Y1 - 1988. N2 - Chorioretinitis due to onchocerciasis is a major cause of blindness, and the pathogenesis is poorly understood. We have developed an experimental model for onchocercal chorioretinitis using cynomolgus monkeys (Macaca fascicularis). Two normal monkeys and two monkeys which had received prior sensitization with subcutaneous injections of live Onchocerca lienalis microfilariae were given intravitreal injections of either 0, 10, 50 or 500 live microfilariae. Posterior segment changes included disc edema, venous engorgement, retinal vasculitis, intraretinal hemorrhage, and progressive retinal pigment epithelial (RPE) disturbances. Histopathological findings included perivascular infiltrates with ...
Looking for online definition of Onchocerca lienalis in the Medical Dictionary? Onchocerca lienalis explanation free. What is Onchocerca lienalis? Meaning of Onchocerca lienalis medical term. What does Onchocerca lienalis mean?
In southern California, ocular infections caused by Onchocerca lupi were diagnosed in 3 dogs (1 in 2006, 2 in 2012). The infectious agent was confirmed through morphologic analysis of fixed parasites in tissues and by PCR and sequencing of amplicons derived from 2 mitochondrially encoded genes and 1 nuclear-encoded gene. A nested PCR based on the sequence of the cytochrome oxidase subunit 1 gene of the parasite was developed and used to screen Simulium black flies collected from southern California for O. lupi DNA. Six (2.8%; 95% CI 0.6%-5.0%) of 213 black flies contained O. lupi DNA. Partial mitochondrial16S rRNA gene sequences from the infected flies matched sequences derived from black fly larvae cytotaxonomically identified as Simulium tribulatum. These data implicate S. tribulatum flies as a putative vector for O. lupi in southern California ...
Adult Onchocerca voluvlus and infective larvae, but not microfilariae contain an immunodominant antigen (33,000 and 21,000 Mr in females, 39,000, 33,000, and 21,000 Mr in males, 133,000 Mr in infective larvae) which is recognized by an Onchocerca-specific mAb. The component is part of the reproductive organs and muscles. 96.2% of onchocerciasis sera contained antibodies detectable by immunoblotting against it. Antigen purified by immunoaffinity chromatography was specifically recognized in immunoblots by onchocerciasis sera, but not by sera from other filarial infections. The high immunogenicity, the specificity, and the occurrence in infective larvae of this antigen indicate an immunodiagnostic potential and a possible role in the immunobiology of the parasite. ...
Onchocerca volvulus has a complex life cycle involving a definitive and intermediate host. The only natural definitive host is humans. The intermediate host is a blackfly in the genus Simulium. Common blackfly hosts include Similium damnosum and S. neavei in Africa and S. ochraceum, S. metallicum, S. callidum, and S. exiguum in the Americas. Adult worms typically live from 8-15 years in human hosts, and microfilariae can live up to 2 years. Adults can be found grouped together in various regions of the human body, with groups containing about half as many males as females. The males move from group to group, inseminating the females. Fertilized eggs develop into live microfilariae in 3-12 weeks, and the females release the microfilariae into the host body. A single female worm may release 1300-1900 microfilariae per day for 9-11 years. The microfilariae migrate away from the adult worms, through blood vessels, lymphatics, skin and connective tissue, and generally settle in the skin.. Since the ...
Cardoso M., Chesnais Cédric, Pion Sébastien, Boussinesq Michel, Ben Naim F., Goze-Bac C., Zanca M. (2017). Three-dimensional visualization of the internal arrangement of onchocercal (Onchocerca volvulus) nodules using high-resolution magnetic resonance imaging. American Journal of Tropical Medicine and Hygiene, 95 (5), 350-351. Meeting Abstract Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH), 65., Atlanta (USA), 2016/11/13-16. ISSN 0002-9637. ...
Adult worms are found in nodules and are hidden from most components of the human immune system. Microfilariae are more vulnerable to attack by immune cells because they exit nodules to complete their lifecycle. O. volvulus can be detected by the immune system through the release of soluble antigens and antigens found on the surface of microfilariae and infective J3 juveniles. These antigens allow the immune system to detect the presence of a foreign organism in the body and trigger an immune response to clear infection.[22] The immune response involves raising antibodies (IgG, IgM and IgE type) that can react with soluble antigens released by Onchocerca volvulus.[23] Opsonising antibodies that tag cells for destruction are also found against the infective J3 stage and microfilariae, but there is not enough evidence at the moment to say whether this is protective.[24] The antigens of O. volvulus are highly complex and show cross-reactivity with several other filarial worms. Little evidence ...
Abstract This paper assesses the effects on adult Onchocerca volvulus of monthly doses of ivermectin (150 µg/kg) given over 4, 8, and 12 months to patients in Guatemala. Nodules were removed 4 months after the last dose; the adult O. volvulus were extracted by collagenase digestion, studied by histological techniques, and compared with worms from untreated patients. Twelve monthly doses killed a proportion of the adult worms (12% of males and 22% of females), leaving the remainder relatively unaffected and the females slowly resuming embryogenesis. After 8 and 12 doses, a number of female worms had resumed embryogenesis in 1 genital tract only, and in 1 female a total degeneration of 1 ovary was seen. Ivermectin also led to a marked drop in the number of male worms in nodules. No serious adverse reactions occurred and the treatment was well accepted.
Diagnostic tools for the detection of infection with Onchocerca volvulus are presently limited to microfilaria detection in skin biopsies and serological assessment using the Ov16 immunoglobulin G4 (IgG4) rapid test, both of which have limited sensitivity. We have investigated the diagnostic performance of a peptide enzyme-linked immunosorbent assay (ELISA) based on immunodominant linear epitopes previously discovered. Peptides that were used in these assays were designated O. volvulus motif peptides (OvMP): OvMP-1 (VSV-EPVTTQET-VSV), OvMP-2 (VSV-KDGEDK-VSV), OvMP-3 (VSV-QTSNLD-VSV), and the combination of the latter two, OvMP-23 (VSV-KDGEDK-VSV-QTSNLD-VSV). Sensitivity (O. volvulus infection), specificity (non-helminth infections), and cross-reactivity (helminth infections) were determined using several panels of clinical plasma isolates. OvMP-1 was found to be very sensitive (100%) and specific (98.7%), but showed substantial cross-reactivity with other helminths. Of the other peptides, ...
Onchocerca volvulus is a pathogenic human filarial parasite which, like other helminth parasites, is capable of evading the hosts immune responses by a variety of defense mechanisms which are likely to include the detoxification and repair mechanisms of the enzyme glutathione S-transferase (GST). In this study, we show that one of the previously described GSTs from O. volvulus appears to possess the characteristics of a secreted enzyme. When the complete O. volvulus GST1 (OvGST1) sequence presented here is compared with those of other GSTs, 50 additional residues at the N terminus are observed, the first 25 showing characteristics of a signal peptide. This is consistent with the N-terminal sequence data on the native mature enzyme which begins at amino acid 26, based on the deduced protein sequence from the cDNA. The native protein, without the signal peptide sequence, possesses a 24-amino-acid extension not present in other GSTs. The deduced amino acid sequence of the OvGST1 cDNA clone was ...
Filarien persistieren bis zu 15 Jahren in ihren Wirten. Als eine Ursache dieser Persistenz diskutiert man die Fähigkeit der Filarien, die Immunantwort des Wirtes gezielt zu modulieren und eine zelluläre Hyporeaktivität zu induzieren. In der vorliegenden Arbeit wurde untersucht, ob ein sezernierter Cysteinproteasen-Inhibitor (Onchocystatin) der humanpathogenen Filarie Onchocerca volvulus immunmodulierende Eigenschaften besitzt und an der Herausbildung eines hyporeaktiven Immunstatus des Wirtes beteiligt ist. Für die Untersuchungen wurde Onchocystatin als full length Molekül (rOv17) und als verkürztes Molekül (trOv17) rekombinant hergestellt. Das verkürzte trOv17 besitzt aufgrund des Fehlens des N-terminalen Bereiches eine verminderte proteaseinhibitorische Aktivität. Die in vitro Studien mit den rekombinant hergestellten O. volvulus Cystatinen verdeutlichen, daß rOv17 und auch trOv17 potente Immunmodulatoren sind, die sowohl die antigenspezifische als auch die polyklonal-stimulierte ...
Current diagnostic instruments to find out an infection with the helminth parasite Onchocerca volvulus have restricted efficiency traits. In earlier research, a proteome-wide display screen was performed to establish linear epitopes on this parasites proteome, leading to the discovery of 1110 antigenic peptide fragments. Here, we investigated three of these peptides utilizing peptide ELISAs and evaluated their sensitivity and specificity. Epitope mapping was carried out, and peptides had been constructed that contained solely the minimal epitope, flanked by a linker. Investigation of the efficiency of these minimal epitope peptides demonstrated that every one three of them have a specificity (as outlined by lack of response in non-helminth-infected people) of 100%, low cross-reactivity (5.6%, 5.6%, and 9.3%, respectively), however low sensitivity (36.9%, 46.5%, and 41.2%, respectively).. Some cross-reactivity was noticed in samples from people contaminated with soil-transmitted helminths or ...
Despite decades of research, scientists have yet to pinpoint the exact cause of nodding syndrome (NS), a disabling disease affecting African children. A new report suggests that blackflies infected with the parasite Onchocerca volvulus may be capable of passing on a secondary pathogen that is to blame for the spread of the disease. When present, the first indication of the disease is an involuntary nodding of the head, followed by epileptic seizures. The condition can cause cognitive deterioration, stunted growth, and in some cases, death ...
Since 2015. Baden-Württenberg-Stipendium Plus: Project for training Cameroonian and German students. Since 2014. Member of the Ethiopian Onchocerciasis Elimination Expert Advisory Committee. Since 2013. Co-ordinator: DFG-Project: Is eradication of human onchocerciasis possible? Entomological, biological and epidemiological studies on filarial parasites in North-Cameroon Univ. Tübingen, MPI Tübingen (PD Dr. A. Streit), BNITH Hamburg (PD Dr. N. Brattig), Univ. of Bamenda (Dr. F. Nguemaim), IRAD Cameroon (Dr. Manchang), TOZARD, Bamenda (Dr. D. Achukwi).. 2008-11. Co-investigator: Studies on the secretom and proteom of filarial worms (Profs. E. Liebau, K. Luersen, N. Brattig. D. Achu-Kwi, D. Ndjonka, Univ. Münster, Hamburg, Ngaoundere, DFG). 2008. Molecular approaches to the population biology of Onchocerca ochengi in cattle (Prof. R. Post, British Mus. Nat. Hist., and LSHTM). Read more. ...
t is currently unknown what causes the disease, but it is believed to be connected to infestations of the parasitic worm Onchocerca volvulus, which is prevalent in all outbreak areas.[10] O. volvulus, a nematode, is carried by the black fly and causes river blindness. In 2004, most children suffering from nodding disease lived close to the Yei River, a hotbed for river blindness, and 93,7% of nodding disease sufferers were found to harbor the parasite--a far higher percentage than in children without the disease.[11] A link between river blindness and normal cases of epilepsy,[12] as well as retarded growth,[13] had been proposed previously, although the evidence for this link is inconclusive.[14] Of the connection between the worm and the disease, Scott Dowell, the lead investigator into the syndrome for the US Centers for Disease Control and Prevention (CDC), stated: We know that [Onchocerca volvulus] is involved in some way, but it is a little puzzling because [the worm] is fairly common in ...
Parasite international open-access, peer-reviewed, online journal publishing high quality papers on all aspects of human and animal parasitology
Ivermectin, Parasite, Onchocerciasis, Population, Human, Disease, Diseases, Helminth, Infection, Infections, Malaria, Onchocerca, Onchocerca Volvulus, Treatment, Volvulus, Helminthiases, Helminths, Research Priorities, Schistosomiasis, Vaccines
Hello, I am new here and looking for a bit of help and make some new friends, my name is Skyblid I beleive I am infested with Onchocerca lupi or one of the many others! I can see what appears to be a yellowish worm looking thing in both my eyes. they are also everywhere else in my body , but the Eyes & Temples seem the worst http://www.drugs.com/news/roundworm-parasite-targets-canine-eyes-56442.html this worm actually targets the Eye I think there are a few others Loa Loa there are so many of these worms ! I am extremely sick the mem loss/confusion/coordination loss is making ...
Onchocerciasis: Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.
La cecità di Fiume, o loncocercosi, è una malattia causata da un verme parassitario trovato soprattutto in Africa. Il verme (volvulus di Onchocerca) è trasmesso agli esseri umani come larve acerbe
The Commissioner for Agriculture and Food Security in Osun State, Mr Wale Adedoyin, yesterday said the government would construct six modern abattoirs in
Abstract Autopsies of two patients with onchocerciasis in the Republic of Zaïre are reported. In one patient with elephantiasis who died following diethylcarbamazine therapy there were large numbers of microfilariae of Onchocerca volvulus in the kidney, liver, pancreas, and lung. In the second patient, who also had leprosy and hyperinfection strongyloidiasis, we found an encapsulated adult O. volvulus in the wall of the thoracic aorta.
Background In West Africa, there are two strains of the filarial parasite Onchocerca volvulus, which differ in their ability to induce ocular disease. Transmission studies have suggested that six sibling species of the parasite vector, the black fly Simulium damnosum sensu lato, allow development of the two strains of O volvulus with varying...
Onchocerciasis, also known as river blindness, is caused by the nematode Onchocerca volvulus and can result in dermatitis, subcutaneous nodules, lymphadenitis, and visual impairment, including blindness. The disease is transmitted by the bite of female Simulium flies (black flies) that bite by day and are found near rapidly flowing rivers and streams. It affects over 17 million people in 25 nations in Africa.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The next journal to be launched by the Public Library of Science is PLoS Neglected Tropical Diseases. To whet your appetite, two papers were published in advance, both on the cause of River Blindness and the evolution of resistance to the anti-parasitic ivermectin: a research paper Genetic Selection of Low Fertile Onchocerca volvulus by Ivermectin Treatment and a commentary Ivermectin Resistance in Onchocerca volvulus - Toward a Genetic Basis.. Shabnam Sigman gives more details about the launch on the PLoS Blog. You can get more information about the new journal here.. ...
1. Brief description of the condition/disease. Onchocerca volvulus infection (i.e. river blindness), which is caused by filariid parasites that are long-lived (8-15 years), is characterized by chronic skin and eye lesions. It is transmitted by Simulium blackflies that breed in rapidly flowing rivers and streams. The embryonic stage (microfilaria), released by female worms, causes most of the pathology. Human infection occurs from the bite of a blackfly that harbours one or more infectious (third-stage) O. volvulus larvae. Male and female worms gather in groups of five or six, intertwined and encased in a fibrous capsule that forms a palpable nodule. The female worms produce thousands of microfilariae (each about the size of a period on this page), which leave the nodule and migrate into the hosts skin, eyes, and other organs. Persons with many fertilized female worms can harbour as many as 200 million microfilariae. The microfilariae live for 9-18 months but cannot develop into adult worms ...
Science & Technology, Life Sciences & Biomedicine, Immunology, IMMUNOLOGY, Onchocerca volvulus, helminth, mycobacterium, PPD, immune response, T-CELL CLONES, SCHISTOSOMA-MANSONI, CYTOKINE RESPONSES, PARASITE ANTIGEN, BRUGIA-MALAYI, TUBERCULOSIS, INFECTION, HELMINTH, PROFILES, RESPONSIVENESS ...
Ecology of Onchocerca volvulus:. O. volvulus cannot survive in the outside environment; therefore it constantly remains within a host, whether it be the black fly or a human. This parasite causes no harm to the intermediate host and only causes harm to its primary host after the parasites death. Upon dying the parasite causes inflammation in various areas of the human body, producing nodules that protrude from the skin. This inflammatory response also causes damage to the optical nerves, causing blindness, which is the origin of the diseases name. As previously stated, there is no preventative vaccine or cure for the disease caused by this parasite, but medicine can be taken to temporarily alleviate the pain. [2]. An example of Onchcerca volvulus tranmission and relation to slavery:. O. volvulus is transmitted from human to human through the bites of black flies. Although the majority of the infections still occur in Western and Central Africa, the parasite and the debilitating disease it ...
Equest Plus Tape now controls tapeworm.The only wormer to protect against encysted small strongyle worms in a single dose.Long acting worm control, protects for 14 - 16 weeks: twice as long as other wormers.Controls all major worms,bots and Onchocerca of horses.Controls summer sores.&#92;nKills worms resistant to Benimidazoles BZ).Low Volume gel formulation.Safe for pregnant mares and breeding stallions and safe for all ages and breeds of horse including foals over 4 weeks of age. Ingredient 20mg Moxidectin and 125mg Praziquantel
Photofacial San Antonio TX - Dr. Vivian Bucay offers IPL Photofacial treatments. Our practice serves San Antonio and surrounding areas in Texas.
The vehicle, it was learnt, was stopped at Odo Oba, Iwo, an entry point to Osun from Oyo State while attempting to enter Osun State. |
The Government of the State Of Osun on Friday again recorded another first when it turned the sod of an Ultra Modern Central Abattoir in Iwo. The first of it
Osun State Polytechnic, Iree 2020/2021 Supplementary Form, HND Form & Part-Time Form is still out call the admin office on 09017032409} for help. Change Of Course Form and Change Of Institution Form is still out to apply call 09017032409 for the registration guild-lines. ...
Onchocerciasis is the worlds second leading infectious cause of blindness. Its control is currently hampered by the lack of a macrofilaricidal drug and by severe adverse events observed when the lone recommended microfilaricide, ivermectin is administered to individuals co-infected with Loa loa. Therefore, there is the need for a safe and effective macrofilaricidal drug that will be able to cure the infection and break transmission cycles, or at least, an alternative microfilaricide that does not kill L. loa microfilariae (mf). Fourteen extracts from two medicinal plants, Tragia benthami and Piper umbellatum were screened in vitro against Onchocerca ochengi parasite and L. loa mf. Activities of extracts on male worms and microfilariae were assessed by motility reduction, while MTT/Formazan assay was used to assess biochemically the death of female worms. Cytotoxicity and acute toxicity of active extracts were tested on monkey kidney cells and Balb/c mice, respectively. At 500 μg/mL, all extracts
Onchocerciasis is diagnosed by detecting microfilariae in skin snips or by detecting OV16 IgG4 antibodies in blood by either enzyme linked immunosorbent assay (ELISA) or a rapid diagnostic test (RDT). Here, we compare the sensitivity and specificity of these three tests in persons with epilepsy living in an onchocerciasis endemic region in the Democratic Republic of Congo. Skin snips and blood samples were collected from 285 individuals for onchocerciasis diagnosis. Three tests were performed: the OV16 RDT (SD Bioline) and the OV16 ELISA both on serum samples, and microscopic detection of microfilariae in skin snips. The sensitivity and specificity of each test was calculated with the combined other tests as a reference. Microfilariae were present in 105 (36.8%) individuals, with a median of 18.5 (6.5–72.0) microfilariae/skin snip. The OV16 RDT and OV16 ELISA were positive in, respectively, 112 (39.3%) and 143 (50.2%) individuals. The OV16 ELISA had the highest sensitivity among the three tests
By examining the genomes of the worms and their symbiotic bacteria, the researchers were able to identify genes that coded for common proteins and molecular reactions essential to infection. 16 of the newly discovered proteins look promising as targets for existing drugs not currently used as treatments for river blindness, adding to the potential new medications for the disease. Further, the authors note, the protein data will accelerate development of new treatments for river blindness as well as other diseases associated with parasitic worm infections.. ###. Additional funding for one of the studies was provided in part by NIHs National Human Genome Research Institute.. ARTICLES: J Cotton et al. The genome of Onchocerca volvulus, agent of river blindness. Nature Microbiology DOI: 10.1038/NMICROBIOL.2016.216 (2016).. YJ Choi et al. Genomic Diversity in Onchocerca volvulus and its Wolbachia endosymbiont. Nature Microbiology DOI: 10.1038/NMICROBIOL.2016.207 (2016).. WHO: Thomas B. Nutman, M.D., ...
INTERVENTION: Few studies have documented the interruption of onchocerciasis and Lymphatic Filariasis (LF) by integrated chemotherapy in Uganda. The study describes the interruption of transmission of the two diseases co-endemic in Obongi focus, north western Uganda. Base line data for Onchocerciasis and LF were collected in 1994 and 2006, respectively. Annual mass drug
We have cloned and characterized the gene for an immunodominant antigen of O. volvulus that is recognized by the sera of 96% of patients with onchocerciasis. Its 1.2-kb mRNA constitutes 0.3% of adult worm poly(A)+ RNA and its cDNA sequence reveals that it is not a highly conserved structural protein such as actin or tubulin. Similar but not identical genes occur in the genomes of related filarie, Brugia malayi and Dirofilaria immitis. The recombinant antigen has both immunodiagnostic and immunoprophylactic significance. ...
The survival in culture of adult female Brugia pahangi, Acanthocheilonema viteae, and Onchocerca volvulus and adult male Onchocerca gibsoni was assessed by measuring parasite motility. Survival of all species was maximal in a nutritionally complex me
The World Health Organization (WHO) is concentrating on intervention techniques to reign in the occurrences of river blindness. They are targeting the areas where these blackflies breed and therefore multiply. Using larvicides in special sprays, these are sprayed around the breeding sites of the rivers which harbor the flies.. In addition, a drug called Ivermectin is often administered to those people who are infected with the parasitic worm transmitted from the blackfly which causes river blindness. This drug kills the young worms inside the body before they can truly become detrimental to a persons health. Both actions have helped lower the statistics of those affected by this tropical disease.. Photo: Onchocerca volvulus in its larval form. Image credit: CDC/Ladene Newto ...
Onchocerciasis (River Blindness) Global Clinical Trials Review, H2, 2016 Onchocerciasis (River Blindness) Global Clinical Trials Review, H2, 2016 Summary GlobalDatas clinical trial report,
Filariasis is a disease group affecting humans and animals, caused by filariae; ie, nematode parasites of the order Filariidae. Filarial parasites can be classified according to the habitat of the adult worms in the vertebral host, as follows (see Pathophysiology, Etiology, and Workup): Cutaneous group - Includes Loa loa, Onchocerca volvulus...
Compare risks and benefits of common medications used for Onchocerciasis, River Blindness. Find the most popular drugs, view ratings, user reviews, and more...
Research Group in Parasitology of the Bonn University are granted by the Bill and Melinda Gates Foundation. The filariae Onchocerca volvulus is endemic in many countries of Sub-Sahara Africa. More than 40 million people are infected with the causative agent O. volvulus and infection can lead to so called riverblindness with more than 270.000 cases.. The research team of Prof. Dr. Achim Hörauf (University Clinic Bonn) tries to find new therapeutic strategies against the infection and are therefore granted by the Bill and Melinda Gates Foundation with 500.000 €.. Here is the press release of the University Bonn. ...
Although suppressive therapy for onchocerciasis with intermittent ivermectin prevents the development of pathology in endemic populations, the clinical and immunologic effects of therapy in the absence of continued exposure are unknown. To address this question, 14 patients treated with ivermectin for onchocerciasis acquired >10 years ago during temporary residence in Africa were reevaluated. None had evidence of continued infection or pathology at follow-up. Although eosinophilia, serum IgE, and antifilarial antibody levels decreased after ivermectin therapy, none of these parameters was useful in predicting the resolution of symptoms in infected patients. Peripheral blood mononuclear cells isolated from patients at follow-up were more responsive to parasite antigen in vitro, which is as assessed by proliferation and production of interferon-γ and interleukin (IL)-5. In contrast, antigen-induced levels of IL-10 were significantly decreased at follow-up, consistent with diminished ...
Equimax LV is an oral broad spectrum control agent for horses in a low volume paste presentation. For treatment and control of all equine parasites including tapeworms and bots. Up to 100% effective against tapeworms, large strongyles, small strongyles, pinworms, ascarids, hairworms, large mouth stomach worms, neck threadworms, bots, lungworms, intestinal threadworms, summer sores. Control of skin lesions caused by Habronema and Draschia spp. cutaneous larvae (summer sores), and Onchocerca spp. microfilariae (cutaneous onchocerciasis). Active Constituents: Ivermectin 18.7 mg/g; Praziquantel 140mg/g Presentation: 6.42g adjustable multidose syringe Dose: 1mL/ 100kg of bodyweight direct into the horses mouth. The syringe delivers sufficient paste to treat 700 kg of bodyweight at the recommended dose rate
Kaiser, C, Kipp, W, Asaba, G, Mugisa, C, Kabagambe, G. et al. (‎1996)‎. The prevalence of epilepsy follows the distribution of onchocerciasis in a West Ugandan focus / C. Kaiser ... [‎et al.]‎. Bulletin of the World Health Organization 1996 ; 74(‎4)‎ : 361-367 https://apps.who.int/iris/handle/10665/54005 ...
An EGF gradient induces the equipotent C. elegans vulval precursor cells (VPCs) to assume the 3˚-3˚-2˚-1˚-2˚-3˚ pattern of cell fates. EGF triggers the LET-60/Ras-LIN-45/Raf-MEK-2/MEK-MPK-1/ERK canonical MAP kinase cascade to induce 1˚ fate and synthesize of DSL ligands for the lateral Notch signal. In turn, LIN-12/Notch induces neighboring cells to become 2˚. In response to lower dose of EGF signal, LET-60/Ras switches effectors to use the RGL-1/RalGEF-RAL-1/Ral modulatory signaling cascade to promote 2˚ fate in support of LIN-12. The goals of this research are to define principles by which signaling networks function and to identify an effector cascade downstream of RAL-1. RAL-1 signals through EXOC-8/Exo84, an established Ral binding partner, GCK-2, a CNH domain-containing MAP4 Kinase, and PMK-1/p38 MAP kinase to promote 2˚ fate. We also show that RGL-1 plays opposing and genetically separable roles in VPC fate patterning. RGL-1 promotes 2˚ fate via canonical GEF-dependent ...
Learn about the causes, symptoms, diagnosis & treatment of Nematodes (Roundworms) from the Professional Version of the Merck Manuals.
Ung L, Acharya NR, Agarwal T, Alfonso EC, Bagga B, Bispo PJ, Burton MJ, Dart JK, Doan T, Fleiszig SM, Garg P, Gilmore MS, Gritz DC, Hazlett LD, Iovieno A, Jhanji V, Kempen JH, Lee CS, Lietman TM, Margolis TP, McLeod SD, Mehta JS, Miller D, Pearlman E, Prajna L, Prajna NV, Seitzman GD, Shanbhag SS, Sharma N, Sharma S, Srinivasan M, Stapleton F, Tan DT, Tandon R, Taylor HR, Tu EY, Tuli SS, Vajpayee RB, Van Gelder RN, Watson SL, Zegans ME, Chodosh J. Infectious corneal ulceration: a proposal for neglected tropical disease status. Bull World Health Organ. 2019 Dec 01; 97(12):854-856 ...
Free, official coding info for 2018 ICD-10-CM B73.02 - includes detailed coding rules & notes, synonyms, ICD-9-CM conversion, index & annotation crosswalks, DRG grouping and more.
Youths in Osun state staged a protest today, claiming that Senator Isiaka Adeleke who died today was poisoned. According to the youths, they believe Adeleke was poisoned by some of his political enemies at a political meeting in the state yesterday. They believe Adelekes political enemies killed him to pave way for another APC aspirant…
6 x Best Junior, 1 x Best Puppy, 21 x BOB, 20 x Best Female, 13 x CAC, 15 x CACIB, 5 x BOG 2., 4 x res. CACIB, 1 x BIS, 2 x BOS, 1 x BOG, 2 x CACA, 6 x res. CAC, 1 x BOG 3., 1 x Top Dog of the Year ...
The intention of our research is to study the life-cycle and the transmission dynamics of the parasite by mathematical models and computer simulations which both are used for planning and optimizing intervention strategies. In this context, mathematical and statistical methods serve as precious tools because they can provide insights where experimental investigations are not possible. Our work may contribute to improve the health of the people living in countries where onchocerciasis is endemic and hence to increase the developmental potential of these countries ...
Properties worth millions of naira were destroyed by a rainstorm in different parts of Ipetumodu, headquarters of Ife-North Local Govt...
Robles was the first person to describe the etiology of the disease, correctly attributing it to infection with Onchocerca ... Puente Rodolfo Robles Fee, W. T. (September 1919). "THE EPIDEMIC OF FILARIA-ONCHOCERCA". California State Journal of Medicine. ... Onchocerca volvulus Transmission Has Been Eliminated from the Central Endemic Zone". The American Journal of Tropical Medicine ...
Onchocerca originated in Africa and was exported to the Americas by the slave trade, as part of the Columbian exchange that ... Onchocerca ochengi, the closest relative of O. volvulus, lives in intradermal cavities in cattle, and is also spread by black ... 2010). "Lack of Onchocerca volvulus transmission in the northern focus in Chiapas". Am. J. Trop. Med. Hyg. 83 (1): 15-20. doi: ... Osei-Atweneboana MY, Eng JK, Boakye DA, Gyapong JO, Prichard RK (June 2007). "Prevalence and intensity of Onchocerca volvulus ...
Onchocerca *Onchocerca gibsoni (parasite of cattle in Asia and Australia). *Onchocerca gutturosa (parasite of cattle in Africa ... Onchocerca volvulus (parasite of humans in Africa,six countries in Latin America, and Yemen) , cause of river blindness) ... Onchocerca lupi (parasite of canines in the United States, Greece, Portugal, Germany, Hungary, Switzerland, and Canada) , cause ... Isolation of Onchocerca lupi in dogs and black flies, California, USA. Emerg Infect Dis [Internet]. 2015 May 5. https://dx.doi. ...
ISBN 3-8258-6824-9.CS1 maint: multiple names: authors list (link) B. O. L. DUKE (1970). "The Effects of Drugs on Onchocerca ... with a relatively high level of infection by the parasitic worm Onchocerca volvulus, the causative agent of river blindness. ...
Onchocerca volvulus Opisthorchiasis Opisthorchis viverrini and Opisthorchis felineus Paracoccidioidomycosis (South American ...
Brumpt E (1919) Une nouvelle filaire pathogène parasite de l'homme (Onchocerca caecutiens, n.sp.). Bull Soc Path Exot 12: 464- ... Filarial worm infection of an adult Onchocerca in America, 2. Erisipela de la costa, an oedema of the face, 3. Conjunctivitis ...
Yagi K, Bain O, Shoho C. "Onchocerca suzukii n. sp. and O. skrjabini (=O. tarsicola) from a relict bovid, Capricornis crispus, ...
Onchocercal keratitis, which follows Onchocerca volvulus infection by infected blackfly bite. These blackfly, Simulium, usually ...
Finally, Wuchereria, Onchocerca, and Dracunculus are transmitted by mosquitoes and flies. In the developing world, the use of ... Onchocerca volvulus infection) Soil-transmitted helminthiasis - this includes ascariasis (Ascaris lumbricoides infection, ...
They also transmit Onchocerca nematode worms to cattle causing bovine onchocerciasis. The former suborder Cyclorrhapha is now ...
ISBN 978-3-662-00226-1. Duke, BO (1968). "Reinfections with Onchocerca volvulus in cured patients exposed to continuing ... Premunity occurs in infections of babesiosis, malaria Onchocerca volvulus, and Trichomonas. Herd immunity Adaptive immune ...
On the anatomy and possible mode of transmission of Filaria (Onchocerca) gibsoni. (1910). Royal Society of New South Wales. The ...
The other two are Mansonella streptocerca and Onchocerca volvulus (causes river blindness). Maturing larvae and adults of the " ... and Onchocerca volvulus in rain forest villages of Cameroon". Medical Microbiology and Immunology. 192: 15-21. doi:10.1007/ ...
Examination of skin snips will identify microfilariae of Onchocerca volvulus and M. streptocerca. Skin snips can be obtained ... Additionally, to differentiate the skin-dwelling filariae M. streptocerca and Onchocerca volvulus, a nested polymerase chain ... "The morphological discrimination of microfilariae of Onchocerca volvulus from Mansonella ozzardi" (PDF). Parasitology. 127 (Pt ...
... yet unlike other Black flies these species are not carriers of Onchocerca volvulus. List of Ethiopian rivers Schütt, Brigitta, ...
Onchocerca volvulus] is involved in some way, but it is a little puzzling because [the worm] is fairly common in areas that do ... "We could not establish any hint that Onchocerca volvulus is actually going into the brain, but what we cannot exclude is that ... but it is believed to be connected to infestations of the parasitic worm Onchocerca volvulus, which is prevalent in all ... "Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus". Science Translational Medicine. 9 ( ...
... a disease caused by the parasitic worm Onchocerca volvulus. In a 2017 publication in the journal Science Translational Medicine ... "Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus". Science Translational Medicine. 9 ( ...
Life cycle of the nematode Onchocerca volvulus.. Parasitic life cycles occur in a variety of forms, all involving the ...
Onchocerca force their own way out of the insect's head into the pool of blood.[citation needed] Triatomine bugs are ...
Onchocerca volvulus manifests itself in the eyes, causing "river blindness" (onchocerciasis), one of the leading causes of ... Intradermal onchocerciasis of cattle results in losses in leather due to Onchocerca dermata, O. ochengi, and O. dukei. O. ... Subcutaneous filariasis is caused by Loa loa (the eye worm), Mansonella streptocerca, and Onchocerca volvulus. These worms ...
... the Onchocerca volvulus, Necator americanus, Wuchereria bancrofti and Dracunculus medinensis are human parasites. Some of ...
... double-blind study of moxidectin in Onchocerca volvulus infection". PLOS Neglected Tropical Diseases. 8 (6): e2953. doi:10.1371 ...
Irvine M, Huima T, Prince AM, Lustigman S (May 1994). "Identification and characterization of an Onchocerca volvulus cDNA clone ... and an Onchocerca volvulus antigen. Goetinck S, Waterston RH (October 1994). "The Caenorhabditis elegans muscle-affecting gene ...
The other two filarial nematodes are Loa loa (the African eye worm), and Onchocerca volvulus (river blindness). The worm is ... M. streptocerca infections fortunately do not cause any nodules, skin disease, or ocular infections like that of Onchocerca ...
Onchocerca volvulus infection promotes immunosuppressive processes within the human host that suppress immunity against ...
M. ozzardi is usually smaller than those Onchocerca Volvulus (that causes human onchocerciasis) when both species co-exist; ...
In 1976, some authors considered it to be a species of the genus Onchocerca -- Onchocerca bohmi (Supperer 1953) Bain et al., ... Bain, O., R.L. Muller, Y. Khamis, J. Guilhon, T. Schillhorn van Veen (1976) "Onchocerca raillieti sp.n. (Filaroidea) chez l'Ane ...
A study examining the epidemiology of Loa loa, Onchocerca volvulus, and M. perstans in the rain forest villages of Cameroon ... Wolbachiae are bacterial endosymbionts of insects and many filarial nematodes, such as Onchocerca volvulus, Wuchereria ... and Onchocerca volvulus in rain forest villages of Cameroon". Medical Microbiology and Immunology. 192 (1): 15-21. doi:10.1007/ ...
Black flies are central to the transmission of the parasitic nematode Onchocerca volvulus which causes onchocerciasis, or " ...
Onchocerca volvulus causes cutaneous onchocerciasis and river blindness The other two are less seriously pathogenic but ...
Onchocerca volvulus is a nematode that causes onchocerciasis (river blindness), and is the second-leading cause of blindness ... Neafie, R.C. (1972). "Morphology of Onchocerca volvulus". American Journal of Clinical Pathology. 57 (5): 574-586. doi:10.1093/ ... Duke, B.O. (1993). "The population dynamics of Onchocerca volvulus in the human host". Tropical Medicine and Parasitology. 44 ( ... Unnasch, Thomas R; Williams, S.A. (2000). "The genomes of Onchocerca volvulus". International Journal for Parasitology. 30 (4 ...
Onchocerca armillata Onchocerca cervicalis Onchocerca dukei Onchocerca fasciata Onchocerca flexuosa Onchocerca gibsoni ... Onchocerca gutturosa Onchocerca jakutensis Onchocerca linealis Onchocerca lupi Onchocerca ochengi Onchocerca ramachandrini ... Onchocerca is a genus of parasitic roundworm. It contains one human parasite - Onchocerca volvulus - which is responsible for ... Uni, S.; Bain, O.; Agatsuma, T.; Harada, M.; Torii, H.; Fukuda, M.; Takaoka, H. (2007). "Onchocerca eberhardi n. sp. (Nematoda ...
ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.. About ASM , Contact Us , Press Room. ASM is a member of. ...
JavaScript is disabled for your browser. Some features of this site may not work without it ...
Two important events in infection by Onchocerca parasites involve cutaneous tissue migration by larval stages. L3 larvae ... Extracellular proteases of Onchocerca Exp Parasitol. 1989 Feb;68(2):176-85. doi: 10.1016/0014-4894(89)90095-7. ... Expression of Onchocerca neutral protease activity was stage specific. No protease activity corresponding to that seen in L3 ... By analogy to other tissue-invasive helminth larvae, it has been proposed that migration of Onchocerca larvae through cutaneous ...
Light micrograph of a section through a skin nodule of a patient with onchocerciasis or river blindness (Onchocerca worm ... Caption: Onchocerca volvulus parasitic worms. Light micrograph of a section through a skin nodule of a patient with ... onchocerca volvulus, onchocerciasis, parasite, parasitic, reproductive, river blindness, section, skin, worm, worms, zoology ... onchocerciasis or river blindness (Onchocerca worm infestation). A longitudinal section of an adult worm is seen across centre ...
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
What is Onchocerca lienalis? Meaning of Onchocerca lienalis medical term. What does Onchocerca lienalis mean? ... Looking for online definition of Onchocerca lienalis in the Medical Dictionary? Onchocerca lienalis explanation free. ... Onchocerca. (redirected from Onchocerca lienalis) Onchocerca. [ong″ko-ser´kah] a genus of parasitic filaria. O. vol′vulus is a ... Onchocerca gutturosa and Onchocerca lienalis in cattle: effect of age, sex, and origin on prevalence of onchocerciasis in ...
Comparison of Diagnostic Tests for Onchocerca volvulus in the Democratic Republic of Congo by An Hotterbeekx 1,*. , Jolien ... "Comparison of Diagnostic Tests for Onchocerca volvulus in the Democratic Republic of Congo." Pathogens 9, no. 6: 435. ... Keywords: onchocerciasis; Onchocerca volvulus; antibodies; diagnosis; OV16 testing; microfilariae; epilepsy onchocerciasis; ... Comparison of Diagnostic Tests for Onchocerca volvulus in the Democratic Republic of Congo. Pathogens 2020, 9, 435. ...
Eberhard ML, Ostovar GA, Chundu K, Hobohm D, Feiz-Erfan I, Mathison BA, Zoonotic Onchocerca lupi infection in a 22-month-old ... Otranto D, Sakru N, Testini G, Gürlü VP, Yakar K, Lia RP, Case report: first evidence of human zoonotic infection by Onchocerca ... Otranto D, Dantas-Torres F, Giannelli A, Latrofa MS, Papadopoulos E, Cardoso L, Zoonotic Onchocerca lupi infection in dogs, ... Mutafchiev Y, Dantas-Torres F, Giannelli A, Abramo F, Papadopoulos E, Cardoso L, Redescription of Onchocerca lupi (Spirurida: ...
Neutrophil granule proteins: evidence for the participation in the host reaction to skin microfilariae of Onchocerca volvulus ... The participation of neutrophil granulocytes in the cellular reaction to skin microfilariae of Onchocerca volvulus was studied ...
Onchocerca lupi Nematode in Cat, Portugal Carla Maia. , Giada Annoscia, Maria Stefania Latrofa, André Pereira, Alessio ... Phylogenetic analysis of partial cytochrome c oxidase subunit 1 gene segment (689 bp) of Onchocerca lupi isolated from a cat in ...
... View/. Open. Full Text (‎347.8Kb)‎ ... Duke, B. O. (‎1968)‎. Reinfections with Onchocerca volvulus in cured patients exposed to continuing transmission.. Bulletin of ...
... with elephantiasis who died following diethylcarbamazine therapy there were large numbers of microfilariae of Onchocerca ... Onchocerciasis: Invasion of Deep Organs by Onchocerca Volvulus Autopsy Findings* * Wayne M. Meyers, Ronald C. Neafie, Daniel H ... with elephantiasis who died following diethylcarbamazine therapy there were large numbers of microfilariae of Onchocerca ...
Abstract A comprehensive study of the transmission of Onchocerca volvulus at 4 locations in Guatemala with different prevalence ... Transmission of Onchocerca Volvulus by Secondary Vectors in Guatemala * Authors: Charles H. Porter, Richard C. Collins ... A comprehensive study of the transmission of Onchocerca volvulus at 4 locations in Guatemala with different prevalence rates of ...
Antigenic Mimicry: Onchocerca volvulus Antigen-Specific T Cells and Ocular Inflammation Nicol M. McKechnie; Werner Gürr; ... The Onchocerca volvulus antigen Ov39 is cross-reactive with the retinal antigen hr44 and induces ocular inflammation in rats ... Antigenic Mimicry: Onchocerca volvulus Antigen-Specific T Cells and Ocular Inflammation You will receive an email whenever this ... McKechnie NM, Gürr W, Braun G. Immunization with the cross-reactive antigens Ov39 from Onchocerca volvulus and hr44 from human ...
The interruption of Onchocerca volvulus and Wuchereria bancrofti transmission by integrated chemotherapy in the Obongi focus, ... The interruption of Onchocerca volvulus and Wuchereria bancrofti transmission by integrated chemotherapy in the Obongi focus, ... The interruption of Onchocerca volvulus and Wuchereria bancrofti transmission by integrated chemotherapy in the Obongi focus, ...
A novel type of glutathione S-transferase in Onchocerca volvulus.. E Liebau, G Wildenburg, R D Walter, K Henkle-Dührsen ... A novel type of glutathione S-transferase in Onchocerca volvulus. Message Subject (Your Name) has forwarded a page to you from ... Onchocerca volvulus is a pathogenic human filarial parasite which, like other helminth parasites, is capable of evading the ...
The nematode was identified as an immature filaria, most likely a member of the genus Onchocerca. CONCLUSIONS Only 3 previous ... reports exist of human infection of the eye caused by zoonotic Onchocerca, 2 involving the subconjunctiva and 1 the cornea. ... Zoonotic intravitreal Onchocerca in Hungary.. @article{Sallo2005ZoonoticIO, title={Zoonotic intravitreal Onchocerca in Hungary ... Ocular zoonotic onchocerca infection in a resident of Oregon.. *Mark L. Eberhard, Annette C Sims, Henry S. Bishop, Blaine A. ...
Onchocerca nematodes are transmitted to humans by blood-sucking vectors during a blood meal. The following species have been ... Our case together with the previous case reports indicate that zoonotic Onchocerca worms exhibit no tissue specificity and an ... responsible for zoonotic infections: Onchocerca cervicalis, O. dewittei japonica, O. gutturosa, O. jakutensis and O. lupi. In ... At present, the following five zoonotic Onchocerca spp. have been identified in humans: O. lupi, O. gutturosa, O. cervicalis, O ...
Small RNA libraries were prepared from total RNA extracted from the nodule fluid of cattle infected with Onchocerca ochengi as ... Here we identify extracellular, parasite-derived small RNAs associated with Onchocerca species infecting cattle and humans. ... well as serum and plasma from humans infected with Onchocerca volvulus in Cameroon and Ghana. Parasite-derived miRNAs were ... identified based on the criteria that sequences unambiguously map to hairpin structures in Onchocerca genomes, do not align to ...
Between 2005 and 2007, the presence of Onchocerca flexuosa (Wedl, 1856) was discovered and investigated in 110 red deer (Cervus ... Levels of infection, pathology and nodule size of Onchocerca flexuosa (Nematoda : Onchocercidae) in red deer (Cervus elaphus) ...
Onchocerca ochengi. Extracted parasites were cultured in RPMI-1640 based media for 05 days in the presence of control drugs, ... and also suggests a new source for isolation of potential lead compounds against Onchocerca volvulus. ... Onchocerciasis caused by Onchocerca volvulus is the worlds second leading infectious cause of blindness. There is currently no ... Onchocerca ochengi, found exclusively in cow is the closest relative to the medically important O. volvulus. Similarities lie ...
Only the hexane extract, an essential oil exhibited anti-Onchocerca activity. The oil killed both the microfilariae and adult ... The present study was undertaken to investigate the acclaimed anti-Onchocerca activity of the roots/rhizomes of Cyperus ... The antifilarial activity was evaluated in vitro on microfilariae (Mfs) and adult worms of the bovine derived Onchocerca ... ochengi, a close relative of Onchocerca volvulus. The viabilities of microfilariae and adult male worms were determined based ...
Doxycycline treatment to eliminate Onchocerca volvulus worms that respond poorly to ivermectin: a double-blind randomised ... Doxycycline treatment to eliminate Onchocerca volvulus worms that respond poorly to ivermectin ...
Evolution of Onchocerca volvulus microfilarial density (mf/mg) between 80 and 180 days after ivermectin treatment.Microfilarial ... Dynamics of Onchocerca volvulus microfilarial densities after ivermectin treatment in an ivermectin-naïve and a multiply ... Dynamics of Onchocerca volvulus microfilarial densities after ivermectin treatment in an ivermectin-naïve and a multiply ... pntd-0002084-g003: Evolution of Onchocerca volvulus microfilarial density (mf/mg) between 80 and 180 days after ivermectin ...
The cattle sera were collected from a herd that had been exposed for six years to natural transmission of Onchocerca spp. The ... Proteins in the ES products and somatic extracts from female and male Onchocerca ochengi worms were recognized by IgG in sera ... ES products and adult worms crude extracts from Onchocerca ochengi, a filarial nematode that infects the African zebu cattle, ... were utilized in the present study as a model for studying Onchocerca volvulus that causes river blindness in man. The ES ...
Onchocerca lupi, a filarioid of zoonotic concern, infects dogs and cats causing ocular lesions of different degrees, from minor ... Onchocerca lupi infection in Turkey: a unique case of a rare human parasite. Acta Parasitol. 2013;58:384-8.View ArticlePubMed ... Zoonotic Onchocerca lupi infection in dogs, Greece and Portugal, 2011-2012. Emerg Infect Dis. 2013;19:2000-3.View ArticlePubMed ... Zoonotic Onchocerca lupi infection in a 22-month-old child in Arizona: first report in the United States and a review of the ...
These programs have managed to virtually eliminate transmission of the parasite causing Onchocerca volvulus from many foci in ... Talsma, Alex Jeanne, "Development of a Confirmatory PCR Assay to Detect Onchocerca volvulus in Pools of Vector Black Flies" ( ... These programs have managed to virtually eliminate transmission of the parasite causing Onchocerca volvulus from many foci in ... Development of a Confirmatory PCR Assay to Detect Onchocerca volvulus in Pools of Vector Black Flies ...
  • Onchocerca volvulus is a nematode that causes onchocerciasis (river blindness), and is the second-leading cause of blindness worldwide after trachoma . (wikipedia.org)
  • It contains one human parasite - Onchocerca volvulus - which is responsible for the neglected disease Onchocerciasis, also known as "river blindness" because the infected humans tend to live near rivers where host black flies live. (wikipedia.org)
  • Light micrograph of a section through a skin nodule of a patient with onchocerciasis or river blindness (Onchocerca worm infestation). (sciencephoto.com)
  • Onchocerciasis (river blindness) is caused by infection with the filarial nematode, Onchocerca volvulus . (arvojournals.org)
  • Onchocerciasis caused by Onchocerca lupi: an emerging zoonotic infection. (semanticscholar.org)
  • Our case together with the previous case reports indicate that zoonotic Onchocerca worms exhibit no tissue specificity and an eye infection has been described in over one third of human zoonotic onchocerciasis cases. (springer.com)
  • Zoonotic onchocerciasis is a vector-transmitted disease caused by nematodes of the genus Onchocerca (Spirurida: Onchocercidae) which are commonly transmitted between wild and domestic animals and occasionally infect humans [ 1 ]. (springer.com)
  • Onchocerciasis caused by Onchocerca volvulus is the world's second leading infectious cause of blindness. (biomedcentral.com)
  • The present study was undertaken to investigate the acclaimed anti- Onchocerca activity of the roots/rhizomes of Cyperus articulatus in the traditional treatment of onchocerciasis in North Western Cameroon and to assess the plant as a new source of potential filaricidal lead compounds. (biomedcentral.com)
  • We now report the isolation, structure elucidation of compounds 1 and 2 and the anti-onchocercal activity of 1 on the adult and juvenile worms (microfilariae) of Onchocerca ochengi and Loa loa , parasites responsible for human onchocerciasis (river blindness). (springer.com)
  • Accepted for publication 20 September 1994 Onchocerciasis in Ecuador: ocular findings in Onchocerca volvulus infected individuals P J Cooper, R Proaflo, C Beltran, M Anselmi, R H Guderian Abstract Little is known of the epidemiology and clinical picture of ocular onchocerciasis in South America. (healthdocbox.com)
  • This paper describes the detailed ocular findings of 785 Onchocerca volvulus infected individuals living in a hyperendemic area for onchocerciasis in Esmeraldas Province of Ecuador. (healthdocbox.com)
  • Onchocerca volvulus is a parasite responsible for Onchocerciasis whose main pathology is blindness. (sciencepublishinggroup.com)
  • Treatment of onchocerciasis due to the immature form of Onchocerca volvulus . (drugs.com)
  • The association between onchocerca infection, vision and nutritional status in children aged 5-14 years in an onchocerciasis endemic area in Nigeria was evaluated using pre-ivermectin baseline data. (healthdocbox.com)
  • An ELISA for human onchocerciasis performed in Guatemala with a crude PBS extract of Onchocerca gutturosa and blood samples collected on filter paper showed a high sensitivity and specificity. (hokudai.ac.jp)
  • In vitro neutrophil-mediated microfilarial killing, humoral responses to crude adult worm antigens (OVAg) and to four recombinant Onchocerca antigens (GST-OV7, GST-OV103, GST-OV3.6, and MBP-OV16), as well as Western blot analysis to stage-specific Onchocerca proteins were studied in individuals from Bassa County, Liberia, infected with onchocerciasis and in endemic normals, defined as individuals without micro-filaridermia. (elsevier.com)
  • Onchocerca armillata Onchocerca cervicalis Onchocerca dukei Onchocerca fasciata Onchocerca flexuosa Onchocerca gibsoni Onchocerca gutturosa Onchocerca jakutensis Onchocerca linealis Onchocerca lupi Onchocerca ochengi Onchocerca ramachandrini Onchocerca tubingensis Onchocerca volvulus "Medical Microbiology" Archived 7 February 2008 at the Wayback Machine, Indiana State University. (wikipedia.org)
  • Small RNA libraries were prepared from total RNA extracted from the nodule fluid of cattle infected with Onchocerca ochengi as well as serum and plasma from humans infected with Onchocerca volvulus in Cameroon and Ghana. (biomedcentral.com)
  • Thus, in contributing to the search for a cure, crude extracts and chromatographic fractions of Craterispermum laurinum and Morinda lucida were screened in vitro, against the bovine and most popular model of the parasite, Onchocerca ochengi . (biomedcentral.com)
  • The antifilarial activity was evaluated in vitro on microfilariae (Mfs) and adult worms of the bovine derived Onchocerca ochengi , a close relative of Onchocerca volvulus . (biomedcentral.com)
  • ES products and adult worms' crude extracts from Onchocerca ochengi , a filarial nematode that infects the African zebu cattle, were utilized in the present study as a model for studying Onchocerca volvulus that causes river blindness in man. (biomedcentral.com)
  • Proteins in the ES products and somatic extracts from female and male Onchocerca ochengi worms were recognized by IgG in sera from both Onchocerca -exposed cattle and humans. (biomedcentral.com)
  • The nematode Onchocerca ochengi is a filarial parasite of cattle, and is native to West Africa, including Cameroon. (wormbase.org)
  • O. ochengi is very closely related to the human-parasitic Onchocerca volvulus , the tractability of the bovine host makes the O. ochengi -cattle model a useful one in vaccine and drug development work for Onchocerca . (wormbase.org)
  • Anti-onchocercal screening of 1 showed moderate inhibition of adult worm motility of Onchocerca ochengi by 60% at the highest concentration (20 µg/mL) and inhibited motility of both the juvenile worms of O. ochengi and Loa loa by 90% at this same concentration. (springer.com)
  • Experimental findings with Litomosoides sigmodontis in mice and Onchocerca ochengi in cattle are placed in the context of how these models can advance our ability to control the human disease. (plos.org)
  • Life cycle of Onchocerca volvulus and Onchocerca ochengi . (plos.org)
  • Here we have identified and characterised a sigma class glycosylated GST (OoGST1), from the cattle-infective filarial nematode Onchocerca ochengi, which is homologous (99% amino acid identity) with an immunodominant GST and potential vaccine candidate from the human parasite, O. volvulus, (OvGST1b). (lstmed.ac.uk)
  • In the search for novel filaricides and alternative medicines, we investigated the selective activity of crude extracts of Margaritaria discoidea and Homalium africanum on Onchocerca ochengi , a model parasite for O. volvulus . (biomedcentral.com)
  • The publication "The genome of Onchocerca volvulus , agent of river blindness" by James A Cotton, et. (wordpress.com)
  • Many filarial nematodes, including Onchocerca volvulus (the cause of human 'River Blindness'), have a mutually dependent relationship with Wolbachia bacteria. (lstmed.ac.uk)
  • River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus , which infects millions in Africa as well as in South and Central America. (plos.org)
  • Infection with Onchocerca volvulus , a filarial nematode, can lead to debilitating skin disease and blindness (river blindness). (plos.org)
  • Two important events in infection by Onchocerca parasites involve cutaneous tissue migration by larval stages. (nih.gov)
  • Characteristic dermal lesions associated with Onchocerca infection in horses. (merckvetmanual.com)
  • Ocular zoonotic onchocerca infection in a resident of Oregon. (semanticscholar.org)
  • Onchocerca jakutensis ocular infection in Poland: a new vector-borne human health risk? (springer.com)
  • Effet de l' infection à Onchocerca volvulus sur la réponse immunitaire humorale (immunoglobulines à Batchenga / par Francisca Monebenimp. (who.int)
  • Integrating multiple biomarkers to increase sensitivity for the detection of Onchocerca volvulus infection. (cdc.gov)
  • We identified the causative agent of a zoonotic Onchocerca infection with multiple nodules in a patient with systemic lupus erythematosus (SLE) who had been receiving hemodialysis. (cdc.gov)
  • To our knowledge, multiple nodules had never been reported in cases of infection with zoonotic Onchocerca . (cdc.gov)
  • Persons between 3 and 100 years of age diagnosed with or suspected of infection with Wuchereria bancrofti, Bugia malayi, Onchocerca volvulus, Loa loa, or other parasitic worms may be eligible for this study. (clinicaltrials.gov)
  • Diagnostic tools for the detection of infection with Onchocerca volvulus are presently limited to microfilaria detection in skin biopsies and serological assessment using the Ov16 immunoglobulin G4 (IgG4) rapid test, both of which have limited sensitivity. (edu.gh)
  • This study was conducted in the Pru and Atebubu Districts in the Brong Ahafo Region to assess the prevalence of Onchocerca volvulus and intestinal parasite infection after 20 years of MDA. (edu.gh)
  • In conclusion, the prevalence of intestinal protozoan and Onchocerca volvulus infections were higher in the Pru district but lower in the Atebubu district whiles intestinal helmnths infection was higher in the Atebubu district but lower in the Pru district. (edu.gh)
  • Performance evaluation of 3 serodiagnostic peptide epitopes and the derived multi-epitope peptide OvNMP-48 for detection of Onchocerca volvulus infection. (gmoseek.com)
  • Current diagnostic instruments to find out an infection with the helminth parasite Onchocerca volvulus have restricted efficiency traits. (gmoseek.com)
  • Some horses carrying heavy infection of Onchocerca microfilariae have experienced reactions with swelling and itching after treatment. (viovet.co.uk)
  • Onchocerca lupi (Spirurida, Onchocercidae) is a nematode that infects the ocular tissues of dogs and humans. (cdc.gov)
  • Phylogenetic analysis of partial cytochrome c oxidase subunit 1 gene segment (689 bp) of Onchocerca lupi isolated from a cat in Portugal (bold) compared with segments from other nematodes and roundworms. (cdc.gov)
  • Intraocular localization of Onchocerca lupi adult worm in a dog with anterior uveitis: A case report. (semanticscholar.org)
  • Image diagnosis of zoonotic onchocercosis by Onchocerca lupi. (semanticscholar.org)
  • Onchocerca cervicalis , O. dewittei japonica , O. gutturosa , O. jakutensis and O. lupi . (springer.com)
  • Onchocerca lupi , a filarioid of zoonotic concern, infects dogs and cats causing ocular lesions of different degrees, from minor to severe. (biomedcentral.com)
  • In southern California, ocular infections caused by Onchocerca lupi were diagnosed in 3 dogs (1 in 2006, 2 in 2012). (cdc.gov)
  • Onchocerca lupi infectionisreportedprimarilyinsymp- by comparing them with sequences available in GenBank. (cdc.gov)
  • Dynamics of Onchocerca volvulus microfilarial densities after ivermectin treatment in an ivermectin-naïve and a multiply treated population from Cameroon. (nih.gov)
  • We assessed, in two Cameroonian foci, whether the microfilaricidal and/or embryostatic effects of ivermectin on Onchocerca volvulus have been altered after several years of drug pressure. (nih.gov)
  • Evolution of Onchocerca volvulus microfilarial density (mf/mg) between 80 and 180 days after ivermectin treatment.Microfilarial density at D180 is plotted against density at D80 (scatterplots), for each individual, in ivermectin-naïve and multiply treated subjects. (nih.gov)
  • Analysis of Onchocerca volvulus à ²-tubulin gene polymorphism in the Mbonge sub-division of Cameroon: Evidence of gene selection by ivermectin. (alliedacademies.org)
  • Burnham, GM 2007, ' Efficacy of ivermectin against Onchocerca volvulus in Ghana ', The Lancet , vol. 370, no. 9593, pp. 1125. (elsevier.com)
  • Limitations of use: Ivermectin has no activity against adult Onchocerca volvulus parasites. (drugs.com)
  • Zoonotic onchocercosis has been attributed to species aries of Amaxades (25°0427E, 41°0712N, altitude 56 that primarily infest cattle ( Onchocerca gutturosa ), m), a small village of 1,000 inhabitants between Xanthi horses ( O. cervicalis ), the European deer ( O. jakutensis ), and Komotini, on the border between Greece and Turkey. (cdc.gov)
  • Onchocerca volvulus is a pathogenic human filarial parasite which, like other helminth parasites, is capable of evading the host's immune responses by a variety of defense mechanisms which are likely to include the detoxification and repair mechanisms of the enzyme glutathione S-transferase (GST). (asm.org)
  • The toxicity of active oxygen species and the protection afforded by anti-oxidant enzymes was assessed for Onchocerca cervicalis microfilariae (mf) in vitro using a radiolabel uptake viability assay . (musc.edu)
  • The adult Onchocerca live in the connective and fatty tissues, usually tightly coiled in connective tissue nodules in the subcutis or deeper tissue layers (Fig. 10.16c). (78stepshealth.us)
  • Female Onchocerca produce microfilariae that live in the tissue within the nodules or skin. (78stepshealth.us)
  • The macrofilaricidal effects of local infiltration of high concentrations of chloroquine into the capsule of onchocercal nodules on adult worms of Onchocerca volvulus was determined. (bvsalud.org)
  • Here we identify extracellular, parasite-derived small RNAs associated with Onchocerca species infecting cattle and humans. (biomedcentral.com)
  • The ES products were generated from adult male and female worms in vitro and analyzed with poly acrylamide gel electrophoresis (PAGE) and enzyme-linked immunosorbent assay (ELISA) using sera from Onchocerca -infected cattle and humans. (biomedcentral.com)
  • The cattle sera were collected from a herd that had been exposed for six years to natural transmission of Onchocerca spp. (biomedcentral.com)
  • Blackflies will feed on both livestock and people, and some species of Onchocerca, other than O. volvulus, will develop within cattle . (newworldencyclopedia.org)
  • Onchocerca nematodes are transmitted to humans by blood-sucking vectors during a blood meal. (springer.com)
  • One gene shown to be linked to IVM selection in Onchocerca volvulus and also known to be associated with IVM resistance in veterinary nematodes is the beta (β) tubulin gene. (alliedacademies.org)
  • In the present study, the cDNA encoding the aspartate aminotransferase (AspAT) of Wolbachia from the human pathogenic filarial parasite Onchocerca volvulus (Ov-WolAspAT) was identified. (wustl.edu)
  • These programs have managed to virtually eliminate transmission of the parasite causing Onchocerca volvulus from many foci in Africa and the Americas. (usf.edu)
  • Cutaneous manifestations of a zoonotic Onchocerca species in an adult male, acquired in Nova Scotia, Canada. (semanticscholar.org)
  • Assignment to the genus Onchocerca was obvious, but species identification still posed a problem because published O . volvulus sequences showed higher similarities among each other (98.8%-100%) than with our sequence. (cdc.gov)
  • Onchocerca microscopy for microfilariae and adult worm are used to complete the identification. (publichealthontario.ca)
  • The worm (Onchocerca volvulus) is transmitted to humans as immature larvae through bites of infected black flies. (news-medical.net)
  • It is a chronic, non-fatal disease caused by a parasitic worm , Onchocerca volvulus, that enters the body through the bite of a blackfly. (newworldencyclopedia.org)
  • A novel type of glutathione S-transferase in Onchocerca volvulus. (asm.org)
  • By analogy to other tissue-invasive helminth larvae, it has been proposed that migration of Onchocerca larvae through cutaneous tissue is facilitated by secretion of proteolytic enzymes. (nih.gov)
  • The cytotoxic effects of neutrophils cocultured with infective third-stage larvae (L3) and autologous serum from three groups of individuals: infected (INF), non-patent endemic normals (EN) and non-endemic controls (NEC), were compared using a MTT (3-(4,5 dimethylthiazol-2yl)-2,5 diphenyl tetrazolium bromide) reduction assay as a biochemical parameter of larval viability. (elsevier.com)
  • Ov-CHI-1 is a chitinase specifically expressed in the infective stage larvae of the human filarial parasite Onchocerca volvulus . (biomedcentral.com)
  • Between 2005 and 2007, the presence of Onchocerca flexuosa (Wedl, 1856) was discovered and investigated in 110 red deer (Cervus elaphus) shot in the Rian˜o Regional Hunting Reserve, in the province of Leo´n (north-western Spain). (csic.es)
  • We identified Onchocerca jakutensis as the causative agent of an unusual human filariasis in a patient with lupus erythematosus. (cdc.gov)
  • Two normal monkeys and two monkeys which had received prior sensitization with subcutaneous injections of live Onchocerca lienalis microfilariae were given intravitreal injections of either 0, 10, 50 or 500 live microfilariae. (elsevier.com)
  • The susceptibility of Brugia malayi and Onchocerca lienalis microfilariae to H2O2 and NO either in cell-free culture or from IFN gamma-activated macrophages was examined. (nih.gov)
  • Prince, A. M. / Onchocerca volvulus : A Comparative Study of in Vitro Neutrophil Killing of Microfilariae and Humoral Responses in Infected and Endemic Normals . (elsevier.com)
  • John O'Neill, an Irish surgeon, first described Onchocerca volvulus in 1874, when he found it to be the causative agent of 'craw-craw', a skin disease found in West Africa . (wikipedia.org)
  • Onchocerca volvulus is endemic in 30 countries in tropical Africa (from the Atlantic coast to the Red Sea) and southern Arabia (Yemen) as well as in six countries in Central and South America (Mexico, Guatemala, Columbia, Venezuela, Brazil, Ecuador). (78stepshealth.us)
  • Onchocerca volvulus can be found mainly in West Africa, and also in Central and South America. (animaldiversity.org)
  • There are recent published information suggesting associations between Nodding Syndrome (NS) with cerebrospinal fluid (CSF) VGKC antibodies and serum leiomidin-1 antibody cross reacting with Onchocerca Volvulus ( OV ). (panafrican-med-journal.com)
  • Characterization of an immunodominant Onchocerca volvulus antigen with patient sera and a monoclonal antibody. (rupress.org)
  • Characterization of a possible tRNA synthetase gene from Onchocerca volvulus. (mcw.edu)
  • Parasite-derived miRNAs were identified based on the criteria that sequences unambiguously map to hairpin structures in Onchocerca genomes, do not align to the human genome and are not present in European control serum. (biomedcentral.com)
  • This study validates the use of these plants by traditional health practitioners in managing the disease, and also suggests a new source for isolation of potential lead compounds against Onchocerca volvulus . (biomedcentral.com)
  • Two constructions in pHS164 vector were designed to permit expression of OV7A and OV4A inserts encoding the N-terminal and C-terminal portion of an aspartic protease from Onchocerca volvulus, respectively. (edu.au)
  • However, zoonotic Onchocerca infections are rare and to date only 13 cases (originating from Europe, Russia, the United States, Canada, and Japan) have been described. (cdc.gov)
  • Molecular cloning of an immunodominant antigen of Onchocerca volvulus. (rupress.org)
  • It is caused by the obligate human filarial nematode Onchocerca volvulus and transmitted by repeated bites of blackflies of the genus Simulium [ 1 , 2 ]. (alliedacademies.org)
  • A new report suggests that blackflies infected with the parasite Onchocerca volvulus may be capable of passing on a secondary pathogen that is to blame for the spread of the disease. (news-medical.net)