AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth CareGeographicals
OmeprazoleAnti-Ulcer AgentsProton Pump Inhibitors2-PyridinylmethylsulfinylbenzimidazolesRanitidineGastric AcidLansoprazoleGastric Acidity DeterminationRabeprazoleEsophagitis, PepticStomach UlcerAmoxicillinHelicobacter pyloriSulfoxidesBenzimidazolesHelicobacter InfectionsGastroesophageal RefluxHistamine H2 AntagonistsClarithromycinMetronidazoleCimetidineFamotidineCross-Over StudiesGastric MucosaPeptic Ulcer HemorrhageAryl Hydrocarbon HydroxylasesDrug Therapy, CombinationGastrinsDrug InteractionsPeptic UlcerDouble-Blind MethodAntacidsEsophagitisHeartburnFurazolidoneDyspepsiaMixed Function OxygenasesBismuthTablets, Enteric-CoatedEndoscopy, GastrointestinalStomachBreath TestsHydrogen-Ion ConcentrationPenicillinsArea Under CurveAntitrichomonal AgentsAdministration, OralPentagastrinH(+)-K(+)-Exchanging ATPaseProton PumpsSucralfateArkansasEnzyme InhibitorsLynestrenolAnti-Bacterial AgentsDexlansoprazoleCytochrome P-450 Enzyme SystemSilicic AcidCytochrome P-450 CYP3AGastric JuiceMephenytoinTreatment OutcomeGastroscopyAluminum HydroxideEsophagusSafroleMagnesium HydroxideAchlorhydriaDrug Administration ScheduleSodium BicarbonateEsophagoscopyTiclopidineRecurrenceCapsulesTetracyclinePepsinogensSuspensionsTinidazole
Omeprazole
A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
Anti-Ulcer Agents
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
Proton Pump Inhibitors
Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.
2-Pyridinylmethylsulfinylbenzimidazoles
Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.
Ranitidine
A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
Gastric Acid
Hydrochloric acid present in GASTRIC JUICE.
Lansoprazole
A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.
Gastric Acidity Determination
Gastric analysis for determination of free acid or total acid.
Rabeprazole
A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
Esophagitis, Peptic
INFLAMMATION of the ESOPHAGUS that is caused by the reflux of GASTRIC JUICE with contents of the STOMACH and DUODENUM.
Stomach Ulcer
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Amoxicillin
A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.
Helicobacter pylori
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
Sulfoxides
Organic compounds that have the general formula R-SO-R. They are obtained by oxidation of mercaptans (analogous to the ketones). (From Hackh's Chemical Dictionary, 4th ed)
Benzimidazoles
Compounds with a BENZENE fused to IMIDAZOLES.
Helicobacter Infections
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Gastroesophageal Reflux
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
Histamine H2 Antagonists
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
Clarithromycin
A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
Metronidazole
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
Cimetidine
A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
Famotidine
A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
Cross-Over Studies
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Gastric Mucosa
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Peptic Ulcer Hemorrhage
Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.
Aryl Hydrocarbon Hydroxylases
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
Drug Therapy, Combination
Therapy with two or more separate preparations given for a combined effect.
Gastrins
A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.
Drug Interactions
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Peptic Ulcer
Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Double-Blind Method
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Antacids
Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.
Esophagitis
INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.
Heartburn
Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.
Furazolidone
A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone acts by gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)
Dyspepsia
Impaired digestion, especially after eating.
Mixed Function Oxygenases
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Bismuth
A metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.
Tablets, Enteric-Coated
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
Endoscopy, Gastrointestinal
Endoscopic examination, therapy or surgery of the gastrointestinal tract.
Stomach
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
Breath Tests
Any tests done on exhaled air.
Hydrogen-Ion Concentration
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Penicillins
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Area Under Curve
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Antitrichomonal Agents
Agents used to treat trichomonas infections.
Administration, Oral
The giving of drugs, chemicals, or other substances by mouth.
Pentagastrin
A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.
H(+)-K(+)-Exchanging ATPase
Proton Pumps
Integral membrane proteins that transport protons across a membrane. This transport can be linked to the hydrolysis of ADENOSINE TRIPHOSPHATE. What is referred to as proton pump inhibitors frequently is about POTASSIUM HYDROGEN ATPASE.
Sucralfate
A basic aluminum complex of sulfated sucrose.
Arkansas
Enzyme Inhibitors
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Lynestrenol
A synthetic progestational hormone used often in mixtures with estrogens as an oral contraceptive.
Anti-Bacterial Agents
Substances that reduce the growth or reproduction of BACTERIA.
Dexlansoprazole
The R-isomer of lansoprazole.
Cytochrome P-450 Enzyme System
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Silicic Acid
A hydrated form of silicon dioxide. It is commonly used in the manufacture of TOOTHPASTES and as a stationary phase for CHROMATOGRAPHY.
Cytochrome P-450 CYP3A
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
Gastric Juice
The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)
Mephenytoin
An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Gastroscopy
Endoscopic examination, therapy or surgery of the interior of the stomach.
Aluminum Hydroxide
A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc.
Esophagus
The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
Safrole
A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
Magnesium Hydroxide
An inorganic compound that occurs in nature as the mineral brucite. It acts as an antacid with cathartic effects.
Achlorhydria
A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.
Drug Administration Schedule
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Sodium Bicarbonate
A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Esophagoscopy
Endoscopic examination, therapy or surgery of the esophagus.
Ticlopidine
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
Recurrence
The return of a sign, symptom, or disease after a remission.
Capsules
Hard or soft soluble containers used for the oral administration of medicine.
Tetracycline
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Pepsinogens
Proenzymes secreted by chief cells, mucous neck cells, and pyloric gland cells, which are converted into pepsin in the presence of gastric acid or pepsin itself. (Dorland, 28th ed) In humans there are 2 related pepsinogen systems: PEPSINOGEN A (formerly pepsinogen I or pepsinogen) and PEPSINOGEN C (formerly pepsinogen II or progastricsin). Pepsinogen B is the name of a pepsinogen from pigs.
Suspensions
Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.
Tinidazole
A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.

Symptomatic gastro-oesophageal reflux disease: double blind controlled study of intermittent treatment with omeprazole or ranitidine. The European Study Group. (1/1291)

OBJECTIVE: To assess intermittent treatment over 12 months in patients with symptomatic gastro-oesophageal reflux disease. DESIGN: Randomised, multicentre, double blind, controlled study. Patients with heartburn and normal endoscopy results or mild erosive changes received omeprazole 10 mg or 20 mg daily or ranitidine 150 mg twice daily for 2 weeks. Patients remaining symptomatic had omeprazole 10 mg or ranitidine dose doubled for another 2 weeks while omeprazole 20 mg was continued for 2 weeks. Patients who were symptomatic or mildly symptomatic were followed up for 12 months. Recurrences of moderate or severe heartburn during follow up were treated with the dose which was successful for initial symptom control. SETTING: Hospitals and primary care practices between 1994 and 1996. SUBJECTS: 677 patients with gastro-oesophageal reflux disease. MAIN OUTCOME MEASURES: Total time off active treatment, time to failure of intermittent treatment, and outcomes ranked from best to worst. RESULTS: 704 patients were randomised, 677 were eligible for analyses; 318 reached the end of the study with intermittent treatment without recourse to maintenance antisecretory drugs. The median number of days off active treatment during follow up was 142 for the entire study (281 for the 526 patients who reached a treatment related end point). Thus, about half the patients did not require treatment for at least 6 months, and this was similar in all three treatment groups. According to outcome, 378 (72%) patients were in the best outcome ranks (no relapse or one (or more) relapse but in remission until 12 months); 630 (93%) had three or fewer relapses in the intermittent treatment phase. Omeprazole 20 mg provided faster relief of heartburn. The results were similar in patients with erosive and non-erosive disease. CONCLUSIONS: Intermittent treatment is effective in managing symptoms of heartburn in half of patients with uncomplicated gastro-oesophageal reflux disease. It is simple and applicable in general practice, where most patients are seen.  (+info)

Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping: possible effect of age, liver disease and length of therapy. (2/1291)

AIMS: To evaluate the reliability of the omeprazole hydroxylation index as a marker for polymorphic CYP2C19 activity in a Japanese population of healthy young subjects (n = 78) and patients with peptic ulcer (n = 72). METHODS: Healthy subjects were administered a single dose of omeprazole (20 mg), whereas patients received 20 mg daily for at least 1 week. The ratio of the serum concentration of omeprazole to hydroxyomeprazole at 3 h postdose was determined and used as a measure of CYP2C19 activity. The CYP2C19 wild type (wt) gene and four mutant alleles associated with the poor metaboliser phenotype of (S)-mephenytoin, CYP2C19*2 in exon 5, CYP2C19*3 in exon 4, CYP2C19m4 in exon 9, and CYP2C19m3 in the initial codon were analysed. RESULTS: In the healthy volunteer study there was complete concordance between genotype and phenotype. However, eight of the patients who had the EM genotype had a high value for their hydroxylation index, and were classified as phenotypic PMs. No CYP2C19m4 and CYP2C19m3 mutations were detected in the eight mismatched patients. They were all genotypic heterozygous EMs, elderly (> or = 65 years) and/or had hepatic disease. Therefore, impaired CYP2C19 activity combined with partial saturation of omeprazole metabolism during multiple dosing may have contributed to the discrepancy between CYP2C19 genotyping and phenotyping. CONCLUSION: Although omeprazole has been used instead of mephenytoin as a probe for polymorphic CYP2C19, it does not appear to be reliable enough for clinical application in Japanese patients.  (+info)

Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole. (3/1291)

BACKGROUND: Omeprazole has a greater intragastric pH elevating effect in Helicobacter pylori positive than negative subjects. Ammonia production by H pylori has been suggested as a probable mechanism. AIMS: To assess the effect of H pylori status on gastric acid secretion during omeprazole treatment, and to examine the possible role of ammonia neutralisation of intragastric acid in increased omeprazole efficacy in infected subjects. METHODS: Twenty H pylori positive and 12 H pylori negative healthy volunteers were examined before and six to eight weeks after commencing omeprazole 40 mg/day. On both occasions plasma gastrin and acid output were measured basally and in response to increasing doses of gastrin 17 (G-17). Gastric juice ammonium concentrations were also measured. RESULTS: Prior to omeprazole, measurements were similar in the H pylori positive and negative subjects. During omeprazole, median basal intragastric pH was higher in the H pylori positive (7.95) versus negative (3.75) subjects (p<0.002). During omeprazole basal, submaximal (180 pmol/kg/h G-17), and maximal acid outputs (800 pmol/kg/h G-17) were lower in H pylori positive subjects (0.0, 3.6, 6.0 mmol/h respectively) versus negative subjects (0.3, 14.2, 18.6 mmol/h) (p<0.03 for each). This effect was not explained by neutralisation by ammonia. CONCLUSION: The presence of H pylori infection leads to a more profound suppression of acid secretion during omeprazole treatment. The effect cannot be explained by neutralisation of intragastric acid by bacterial ammonia production and its precise mechanism has to be explained.  (+info)

Eradication of Helicobacter pylori in functional dyspepsia: randomised double blind placebo controlled trial with 12 months' follow up. The Optimal Regimen Cures Helicobacter Induced Dyspepsia (ORCHID) Study Group. (4/1291)

OBJECTIVES: To determine whether eradication of Helicobacter pylori relieves the symptoms of functional dyspepsia. DESIGN: Multicentre randomised double blind placebo controlled trial. SUBJECTS: 278 patients infected with H pylori who had functional dyspepsia. SETTING: Predominantly secondary care centres in Australia, New Zealand, and Europe. INTERVENTION: Patients randomised to receive omeprazole 20 mg twice daily, amoxicillin 1000 mg twice daily, and clarithromycin 500 mg twice daily or placebo for 7 days. Patients were followed up for 12 months. MAIN OUTCOME MEASURES: Symptom status (assessed by diary cards) and presence of H pylori (assessed by gastric biopsies and 13C-urea breath testing using urea labelled with carbon-13). RESULTS: H pylori was eradicated in 113 patients (85%) in the treatment group and 6 patients (4%) in the placebo group. At 12 months follow up there was no significant difference between the proportion of patients treated successfully by intention to treat in the eradication arm (24%, 95% confidence interval 17% to 32%) and the proportion of patients treated successfully by intention to treat in the placebo group (22%, 15% to 30%). Changes in symptom scores and quality of life did not significantly differ between the treatment and placebo groups. When the groups were combined, there was a significant association between treatment success and chronic gastritis score at 12 months; 41/127 (32%) patients with no or mild gastritis were successfully treated compared with 21/123 (17%) patients with persistent gastritis (P=0. 008). CONCLUSION: No convincing evidence was found that eradication of H pylori relieves the symptoms of functional dyspepsia 12 months after treatment.  (+info)

Treatment of Helicobacter pylori and Chlamydia pneumoniae infections decreases fibrinogen plasma level in patients with ischemic heart disease. (5/1291)

BACKGROUND: Chronic Chlamydia pneumoniae and Helicobacter pylori infections could be a risk factor for ischemic heart disease (IHD), possibly by increasing fibrinogen levels. The aim of our study was to evaluate changes in fibrinogen level in patients with IHD and H pylori and/or C pneumoniae positivity randomly assigned to antibiotic treatment. METHODS AND RESULTS: Eighty-four patients with chronic IHD, H pylori and/or C pneumoniae antibodies, and normal acute-phase reactants were randomly assigned to treatment or no treatment. Treatment consisted of omeprazole, clarithromycin, and tinidazole in H pylori-positive patients and clarithromycin alone in C pneumoniae-positive patients. The effect of treatment and other baseline variables on fibrinogen levels, determined at 6 months, was evaluated by multivariate analysis. Treatment significantly reduced fibrinogen level at 6 months in the overall study population and in the groups of patients divided according to H pylori or C pneumoniae positivity. In the 43 treated patients, mean (+/-SD) basal fibrinogen was 3.65+/-0.58 g/L, and mean final fibrinogen was 3. 09+/-0.52 g/dL (P<0.001), whereas in the 41 untreated patients, mean basal and final fibrinogen levels were 3.45+/-0.70 and 3.61+/-0.71 g/L, respectively. The largest decrease was observed in patients with both infections. Fibrinogen changes were also significantly and negatively correlated with age. CONCLUSIONS: Our data suggest that a short, safe, and effective course of antibiotic therapy might be suggested as a means of interacting with an "emerging" risk factor.  (+info)

Review article: Helicobacter pylori and gastro-oesophageal reflux disease-clinical implications and management. (6/1291)

A significant proportion of patients with gastro-oesophageal reflux disease (GERD) have Helicobacter pylori infection, but it is unclear whether or not H. pylori should be treated in this clinical setting. The aim of this review was to critically assess the relationship between H. pylori and GERD and its potential implications for the management of GERD. Data for this review were gathered from the following sources up to April 1998-the biomedical database MEDLINE, a detailed review of medical journals, and a review of abstracts submitted to relevant international meetings. On average, 40% of GERD patients carry H. pylori infection, with a reported infection prevalence ranging from 16% to 88%. To date, there has been no reported controlled trial of effective H. pylori therapy in GERD. GERD has been reported to develop de novo following the cure of H. pylori in peptic ulcer disease. In the presence of H. pylori, proton pump inhibitor therapy appears to accelerate the development of atrophic corpus gastritis, a potentially precancerous condition. Conversely, proton pump inhibitor therapy seems to become less effective after cure of H. pylori. The mechanisms underlying these important contrasting phenomena are poorly understood. The relationship between H. pylori and GERD is complex, and it is difficult to give definitive guidelines on the management of H. pylori infection in GERD. Controlled trials of H. pylori therapy in GERD are urgently needed, as well as further long-term data on both the natural history of gastric histopathological changes in the H. pylori-positive GERD patient treated with proton pump inhibitors, and the impact of H. pylori status on the clinical efficacy of antisecretory therapy. Pending these data, it is perhaps advisable to advocate cure of H. pylori in young patients with proton pump inhibitor-dependent GERD who, in the absence of anti-reflux surgery, are faced with the likelihood of long-term medical therapy.  (+info)

Serum gastrin and chromogranin A during medium- and long-term acid suppressive therapy: a case-control study. (7/1291)

BACKGROUND: Serum chromogranin A (CgA) is regarded as a reliable marker of neuroendocrine proliferation. We previously described increased serum CgA levels during short-term profound gastric acid inhibition. AIM: To investigate serum gastrin and CgA levels in dyspeptic patients during continuous medium- (6 weeks to 1 year), or long-term (1-8 years) gastric acid suppressive therapy. PATIENTS AND METHODS: 114 consecutive dyspeptic patients referred for upper gastrointestinal endoscopy were enrolled in a cross-sectional, case-control study [62 patients on continuous antisecretory therapy, either with proton pump inhibitors (n = 47) or H2-receptor antagonists (H2RA) (n = 15) for gastro-oesophageal reflux disease with or without Barrett's oesophagus or functional dyspepsia, and 52 age- and sex-matched patients without medical acid inhibition and with normal endoscopic findings (control group)]. Omeprazole doses ranged from 20 mg to 80 mg daily and ranitidine from 150 mg to 450 mg daily. Fasting serum CgA and serum gastrin levels were measured by radioimmunoassay (reference values: serum CgA < 4.0 nmol/L; serum gastrin < 85 ng/L). RESULTS: Fasting serum CgA levels positively correlated with serum gastrin in the entire study population (r = 0. 55, P = 0.0001). Median serum CgA values were higher in patients treated with a proton pump inhibitor than H2RA [2.8 (2.0-5.9) nmol/L vs. 2 (1.9-2.3) nmol/L, P < 0.002] and controls [2.8 (2.0-5.9) nmol/L vs. 1.8 (1.5-2.2) nmol/L, P < 0.0001) and did not differ between patients treated with H2RA or controls. Serum gastrin and CgA levels in patients on proton pump inhibitor therapy positively correlated with the degree and duration of acid inhibition. Patients on long-term proton pump inhibitor therapy had significantly higher fasting serum gastrin and CgA than those on medium-term proton pump inhibitor therapy [127 (73-217) ng/L vs. 49 (29-78) ng/L, P < 0.0001 and 4.8 (2.8-8) ng/L vs. 2.1 (1.9-2.6) ng/L, P < 0.001]. No such relation was found in patients on medium- vs. long-term H2RA. Overall, patients with positive Helicobacter pylori serology had higher serum gastrin and CgA levels than those with negative H. pylori serology [51 (27-119) ng/L vs. 27 (14-79) ng/L, P = 0.01, 2.4 (1.9-3.4) nmol/L vs. 2.0 (1.7-2.5) nmol/L, P = 0.05]. CONCLUSIONS: During long-term continuous proton pump inhibitor treatment, serum gastrin and CgA levels are significantly elevated compared to H2RA treatment and nontreated dyspeptic controls. H. pylori infection seems to affect gastric ECL cell secretory function. Increased serum CgA values during long-term profound gastric acid inhibition could reflect either gastric enterochromaffin-like cell hyperfunction or proliferative changes.  (+info)

Comparison of rabeprazole 20 mg versus omeprazole 20 mg in the treatment of active duodenal ulcer: a European multicentre study. (8/1291)

BACKGROUND: Rabeprazole sodium is the newest member of a class of substituted benzimidazole molecules known as proton pump inhibitors. Other proton pump inhibitors have been shown to be effective in healing active duodenal ulcer. METHOD: This randomized, double-blind, multicentre study, conducted at 25 European sites, compared the efficacy and tolerability of rabeprazole and omeprazole in patients with active duodenal ulcers. One hundred and two patients with active duodenal ulcer received rabeprazole 20 mg and 103 patients omeprazole 20 mg once daily for 2 or 4 weeks, with ulcer healing monitored by endoscopy. RESULTS: After 2 weeks, complete ulcer healing was documented in 69% of patients given rabeprazole 20 mg and in 62% of patients given omeprazole 20 mg (N.S.). After 4 weeks, healing rates were 98% in the rabeprazole group and 93% in the omeprazole group (P = 0.083). Rabeprazole-treated patients had significantly greater improvement in daytime pain symptom relief than those treated with omeprazole at the conclusion of the study (P = 0.038). Both drugs were well tolerated over the 4-week treatment period. Mean changes from baseline to end-point in fasting serum gastrin were significantly greater in the rabeprazole group, but at end-point mean values were well within normal limits for both groups. No clinically meaningful changes or other between-group differences were observed in laboratory parameters. CONCLUSION: In this study, rabeprazole produced healing rates equivalent to omeprazole at weeks 2 and 4, and provided significantly greater improvement in daytime pain. Both treatments were well tolerated.  (+info)

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Marmulak, T., Stanley, S., Kass, P.H., Wiebe, V., McKemie, D., Pusterla, N. Pharmacokinetics of intrarectal omeprazole in alpacas. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2009.00149.x. The purpose of this study was to evaluate the pharmacokinetics of omeprazole in three different vehicles when administered rectally to six alpacas. Alpacas were given single doses of omeprazole (4 mg/kg) in a double-blinded, randomized cross-over design with a 1 week washout period. Omeprazole formulations consisted of (1) Treatment A: omeprazole paste mixed in surgical lubricant (2) Treatment B: omeprazole capsule contents in 8.4% sodium bicarbonate and (3) Treatment C: omeprazole capsule contents in surgical lubricant and 8.4% sodium bicarbonate solution. Plasma samples were drawn at 0, 5, 10, 15, 30, 45, 60, 90, 120, 180, 300 and 480 min. Omeprazole plasma concentrations were determined by high-pressure liquid chromatography-mass spectrometry. Pharmacokinetic results demonstrated median peak plasma ...
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https://clinicaltrials.gov/ct2/show/NCT01415128
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http://annals.org/aim/article-abstract/708408/omeprazole-therapy-resistant-reflux-disease
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Protective Effect of Tegaserod Against Indomethacin-Induced Gastric Injury in the Rat [Abstract]Protective Effect of Tegaserod Against Indomethacin-Induced Gastric Injury in the Rat [Abstract]
Gastric contractions induced by non-steroidal anti-inflammatory drugs (NSAIDs) contribute to mucosal ulceration. The goal of the present study was to investigate whether maintaining normal gastric motility provides protection against NSAIDs. A rat model of indomethacin-induced gastric mucosal injury and muscle hypercontratility was used to evaluate the protective effect of pretreatment with the 5-HT4 receptor agonist tegaserod (1 mg/kg b.i.d.) in comparison to the effect of the proton pump inhibitor omeprazole (20 mg/kg b.i.d). Indomethacin induced mucosal ulceration associated with hypercontractility of isolated antral muscle strips in response to KCl, carbachol, 5-HT or electrical field stimulation. Pretreatment with tegaserod alone or in combination with omeprazole prevented both mucosal ulceration and muscle hypercontractility. In contrast, omeprazole protected the mucosa without preventing the development of muscle hypercontractility. The results show that activation of peripheral 5-HT4 ...
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Activation of hedgehog (Hh) signaling contributes to the progression of Barretts esophagus (BE), which increases the risk of esophageal adenocarcinoma. Recent clinical studies revealed that proton-pump inhibitors (PPIs) but not H2 receptor antagonists (H2RAs) were associated with a decreased risk of esophageal adenocarcinoma. We would like to know whether PPIs interfere with BE progression during BE treatment. Here, we explored the role of omeprazole on Hh signaling and expression of two crucial biomarkers of BE, SOX9 and CDX2. We demonstrated that bile acids elevated expression of Hh pathway target genes, such as GLI1 and PTCH1, and induced SOX9 and CDX2 up-regulation in both CP-A and CP-B cells. Omeprazole, but not famotidine, down-regulated these genes induced by bile acids. In addition, omeprazole-induced down-regulation of SOX9 and CDX2 was mediated by Hh signaling. To explore the mechanisms by which omeprazole inhibits Hh signaling, we performed luciferase assay but did not find any ...
https://portlandpress.com/clinsci/article-abstract/133/3/483/111061/Omeprazole-prevents-CDX2-and-SOX9-expression-by
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Gastritis, symptoms, causes and therapy - HumanitasaluteGastritis, symptoms, causes and therapy - Humanitasalute
The first thing to do in young people is to research the Helicobacter Pylori. The bacterium can be tested by faecal, blood or breath tests (urea Breath Test). The breath test is performed by making the patient drink a particular solution containing a marked urea with a carbon isotope (non-radioactive), therefore the patient must breathe inside a machine or in a tube. The bacterium is able to split the urea into water and carbon dioxide, if in the patients exhaled there is the presence of carbon dioxide marked means that there is infection with Helicobacter Pylori.. For those symptomatic subjects who do not respond to therapy and are more than 45 years old, an esophago-gastro-duodenoscopy or EGDS is recommended. In these cases, in fact, the same symptoms of gastritis could be the expression of other and much more serious diseases, including tumors. To treat gastritis, it is advisable to reduce stomach acidity with Anti-H2 drugs (ranitidine type) or proton pump inhibitors (omeprazole type), or ...
https://www.humanitas.net/health/health-a-z/intestine-digestion/3840-gastritis-symptoms-causes-and-therapy/
UlcerGard® (omeprazole) INHIBITS ACID PRODUCTION AT THE SOURCE. | UlcergardUlcerGard® (omeprazole) INHIBITS ACID PRODUCTION AT THE SOURCE. | Ulcergard
Illegally manufactured omeprazole products which many horse owners assume are legitimate generics of ULCERGARD have underperformed versus the FDA-approved product and have been found to vary widely in the amount of omeprazole they actually contain.3,4 In fact, when a product manufactured under the name of GastroMax3 was evaluated by UC Davis, it contained less than two-thirds of the omeprazole than its label claimed.5. When it comes to stability and efficacy, compounded omeprazole pastes simply dont measure up. In a 60-day study of five compounded pastes, formulations started as low as 63% of labeled concentration on day 0, and dipped to as low as 17% by day 60, and were ineffective in promoting the healing of stomach ulcers in horses.3 If its not stable in a lab environment, how could it possibly survive a barn setting? GASTROGARD concentrations remained stable throughout the study.. What this means is that if you are using an illegally manufactured product, you are likely not getting all of ...
http://ulcergard.com/prevent-with-ulcergard/how-ulcergard-works
GastroGard® (omeprazole) INHIBITS ACID PRODUCTION AT THE SOURCE. | UlcergardGastroGard® (omeprazole) INHIBITS ACID PRODUCTION AT THE SOURCE. | Ulcergard
Illegally manufactured omeprazole products which many horse owners assume are legitimate generics of ULCERGARD have underperformed versus the FDA-approved product and have been found to vary widely in the amount of omeprazole they actually contain.3,4 In fact, when a product manufactured under the name of GastroMax3 was evaluated by UC Davis, it contained less than two-thirds of the omeprazole than its label claimed.5. When it comes to stability and efficacy, compounded omeprazole pastes simply dont measure up. In a 60-day study of five compounded pastes, formulations started as low as 63% of labeled concentration on day 0, and dipped to as low as 17% by day 60, and were ineffective in promoting the healing of stomach ulcers in horses.3 If its not stable in a lab environment, how could it possibly survive a barn setting? GASTROGARD concentrations remained stable throughout the study.. What this means is that if you are using an illegally manufactured product, you are likely not getting all of ...
http://ulcergard.com/treat-with-gastrogard/how-gastrogard-works
EQUATE OMEPRAZOLE DELAYED RELEASE ACID REDUCER (omeprazole tablet, delayed release) | FDA Warnings & Precations | Healthgrades...EQUATE OMEPRAZOLE DELAYED RELEASE ACID REDUCER (omeprazole tablet, delayed release) | FDA Warnings & Precations | Healthgrades...
The FDA requires all potential medication risks for EQUATE OMEPRAZOLE DELAYED RELEASE ACID REDUCER (omeprazole tablet, delayed release) be disclosed to consumers, no matter how rare. Here are the warnings and precautions for Equate omeprazole delayed release acid reducer.
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Dyspepsia: a common but highly treatable condition | Nursing in PracticeDyspepsia: a common but highly treatable condition | Nursing in Practice
Helicobacter pylori is a bacterium linked with duodenal and gastric ulcers and is associated with an increased incidence of gastric cancers. Ingestion of the bacteria can cause acute gastritis with associated nausea and vomiting and eventually chronic ulceration.(9) Elimination of the infection with a combination of the proton pump inhibitor omeprazole and clarithromycin, a macrolide antibiotic, can achieve a 70-80% cure rate and alters the course of the disease from a chronic, relapsing condition to a cure.(10) The best test for identification of H pylori and for confirmation of eradication is the (13)C breath test - this is a carbon-tagged breath test that depends on urease degradation of urea to produce tagged carbon, which then appears in exhaled breath. This test can be performed in the treatment room and is available on prescription.(1) ...
https://www.nursinginpractice.com/article/dyspepsia-common-highly-treatable-condition
Sufotidine - WikipediaSufotidine - Wikipedia
Sufotidine (INN,[1] USAN, codenamed AH25352) is a long-acting competitive H2 receptor antagonist which was under development as an antiulcerant by Glaxo (now GlaxoSmithKline).[2] It was planned to be a follow-up compound to ranitidine (Zantac).[3] When taken in doses of 600 mg twice daily it induced virtually 24-hour gastric anacidity[4] thus closely resembling the antisecretory effect of the proton pump inhibitor omeprazole.[5] Its development was terminated in 1989[6] from phase III clinical trials based on the appearance of carcinoid tumors in long-term toxicity testing in rodents.[7] ...
https://en.wikipedia.org/wiki/Sufotidine
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omeprazole | Cignaomeprazole | Cigna
Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. Omeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus...
https://www.cigna.com/healthwellness/hw/medications/omeprazole-d00325a1
Week 20 - Omeprazole for Bleeding Peptic Ulcers - 52 in 52Week 20 - Omeprazole for Bleeding Peptic Ulcers - 52 in 52
Intravenous proton-pump inhibitor (PPI) therapy is a cornerstone of modern therapy for bleeding peptic ulcers. However, prior to this 2000 study by Lau et al., the role of PPIs in the prevention of recurrent bleeding after endoscopic treatment was unclear. At the time, re-bleeding rates after endoscopic treatment were noted to be approximately 15-20%. Although other studies had approached this question, no high-quality, large, blinded RCT had examined adjuvant PPI use immediately following endoscopic treatment.. The study enrolled patients who had a bleeding gastroduodenal ulcer visualized on endoscopy and in whom hemostasis was achieved following epinephrine injection and thermocoagulation. Enrollees were randomized to treatment with either omeprazole 80mg IV bolus followed by 8mg/hr infusion x72 hours then followed by omeprazole 20mg PO x8 weeks or to placebo bolus + drip x72 hours followed by omeprazole 20mg PO x8 weeks. The primary outcome was recurrent bleeding within 30 days. Secondary ...
http://www.medicine52in52.com/week-20-omeprazole-for-bleeding-peptic-ulcers/
Omeprazole 20 capsules Archives - SupermaxOmeprazole 20 capsules Archives - Supermax
What is omeprazole used for Omeprazole is a medicine prescribed for treating certain stomach conditions like acid reflux, heartburn, and ulcers, difficulty swallowing, and persistent cough. This medication helps heal acid damage to the stomach and oesophagus, and also helps prevent ulcers. Omeprazole comes under a specific category of drugs, which is proton pump inhibitors. When and how to take… ...
https://supermaxpharma.com/tag/omeprazole-20-capsules/
METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF RESIDUAL SOLVENTS IN OMEPRAZOLE API BY USING HEADSPACE GAS...METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF RESIDUAL SOLVENTS IN OMEPRAZOLE API BY USING HEADSPACE GAS...
Residual solvents in pharmaceutical samples are monitored using gas chromatography with head space. Based on good manufacturing practices, measuring residual solvents is mandatory for the release testing of all active pharmaceutical ingredients (API). The analysis of residual organic solvents (methanol, ethanol, acetone and toluene) in Omeprazole API was investigated. Omeprazole is a potent reversible inhibitor of the gastric proton pump H+/K+-ATPase. The Head space gas chromatography (HSGC) method described in this investigation utilized a DB - 624, 30 m long x 0.32 mm internal diameter, 1.8 μm thick column. Since Omeprazole is a thermally labile compound, the selection of the proper injector temperature is critical to the success of the analysis. The injector temperature was set at 180°C to prevent degradation. The initial oven temperature was set at 50°C for 10 min and programmed at a rate of 30°C minâˆ1 to a final temperature of 200°C for 10 min. Nitrogen was used as a ...
https://innovareacademics.in/journals/index.php/ajpcr/article/view/635
OmeprazoleOmeprazole
... is available as tablets and capsules (containing omeprazole or omeprazole magnesium) in strengths of 10, 20, 40, and ... "Omeprazole MSDS". Retrieved October 21, 2018.. *^ "Omeprazole 40 mg Powder for Solution for Infusion". EMC. February 10, 2016. ... "Omeprazole, in The Free Medical Dictionary". Retrieved 11 November 2010.. *^ "Omeprazole". Drugs.com. Archived from the ... the pharmacokinetics of the omeprazole molecule strongly suggest the safety of omeprazole use during breastfeeding: *Omeprazole ...
https://en.wikipedia.org/wiki/Prilosec
Schedule HSchedule H
... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
https://en.wikipedia.org/wiki/Schedule_H
Proton-pump inhibitorProton-pump inhibitor
... with omeprazole being launched in 1988. Most of these medications are benzimidazole derivatives, related to omeprazole, but ... Omeprazole is the specific listed example. These medications are used in the treatment of many conditions, such as: Dyspepsia ... The rate of omeprazole absorption is decreased by concomitant food intake. In addition, the absorption of lansoprazole and ... Medically used proton pump inhibitors:[citation needed] Omeprazole (Over-the-counter drug (OTC) and Rx-only in the US) ...
https://en.wikipedia.org/wiki/Proton-pump_inhibitor
AstraZenecaAstraZeneca
... patented S-omeprazole in pure form, pointing out that since some people metabolise R-omeprazole slowly, pure S- ... When it is manufactured the result is a mixture of two mirror-imaged molecules, R and S. Two years before the omeprazole patent ... The (R)-entantiomer of omeprazole is metabolized exclusively by the enzyme CYP2C19, which is expressed in very low amounts by 3 ... While omeprazole is approved only at doses of up to 20 mg for the treatment of gastroesophageal reflux,[81] esomeprazole is ...
https://en.wikipedia.org/wiki/AstraZeneca
Racemic mixtureRacemic mixture
... compare omeprazole and esomeprazole. While often only one enantiomer of the drug may be active, there are cases in which the ...
https://en.wikipedia.org/wiki/Racemic_mixture
TimoprazoleTimoprazole
414-5. Hemenway JN (2007). "Case Study: Omeprazole (Prilosec)". Prodrugs. Biotechnology: Pharmaceutical Aspects. pp. 1313-21. ...
https://en.wikipedia.org/wiki/Timoprazole
Discovery and development of proton pump inhibitorsDiscovery and development of proton pump inhibitors
Omeprazole (brand names Losec, Prilosec, Zegerid, Ocid, Lomac, Omepral, Omez, Ultop, Ortanol, Gastrozol) Omeprazole was the ... For example omeprazole is unstable in acid with a half-life of 2 min at pH 1-3, but is significantly more stable at pH 7 (half- ... Omeprazole reacts with cysteine 813 and 892. Rabeprazole binds to cysteine 813 and both 892 and 321. Lansoprazole reacts with ... Omeprazole showed an inter-individual variability and therefore a significant number of patients with acid-related disorders ...
https://en.wikipedia.org/wiki/Discovery_and_development_of_proton_pump_inhibitors
GastrinomaGastrinoma
Proton-pump inhibitors such as omeprazole. This group of medications suppress the acid secretion. H2-receptor antagonist ...
https://en.wikipedia.org/wiki/Gastrinoma
DomperidoneDomperidone
... /omeprazole (10 mg/10 mg) Saudi Arabia. JamJoom Pharmaceuticals. Dompy. Domperidone 10 mg tablets ...
https://en.wikipedia.org/wiki/Domperidone
EsomeprazoleEsomeprazole
... and its metabolites are analytically indistinguishable from omeprazole and the corresponding omeprazole ... and R-omeprazole); critics said the company was trying to "evergreen" its omeprazole patent by patenting the pure esomeprazole ... Esomeprazole is the (S)-(−)-isomer of omeprazole. It works by blocking H+/K+-ATPase in the parietal cells of the stomach. It ... Esomeprazole's successful predecessor, omeprazole, is a mixture of two mirror-imaged molecules (esomeprazole which is the S- ...
https://en.wikipedia.org/wiki/Esomeprazole
COVID-19 pandemic in Tamil NaduCOVID-19 pandemic in Tamil Nadu
Omeprazole 40 mg, twice daily for five days; Ondansetron 4 mg, twice daily for five days; Zinc and Vitamin C supplements; ...
https://en.wikipedia.org/wiki/COVID-19_pandemic_in_Tamil_Nadu
Equine gastric ulcer syndromeEquine gastric ulcer syndrome
Omeprazole requires 3-5 days to reach steady-state levels in horses, so horses suffering from ulcers are often started on H2 ... It is best to exercise a horse 2-8 hours after administration of omeprazole, and it may be taken up more quickly if the horse ... Prophylactic use of both omeprazole and H2 antagonists such as ranitidine, cimetidine, and famotidine can be used to help ... This is also true for omeprazole doses, especially if given orally. Antacids have a short duration of effectiveness, and ...
https://en.wikipedia.org/wiki/Equine_gastric_ulcer_syndrome
Bismuth subcitrateBismuth subcitrate
Bismuth absorption is increased by ranitidine and omeprazole. The mechanism of action of bismuth is not known. It has been ...
https://en.wikipedia.org/wiki/Bismuth_subcitrate
Drug interactionDrug interaction
Comment in: Mouly S, Paine MF (August 2001). "Effect of grapefruit juice on the disposition of omeprazole". British Journal of ...
https://en.wikipedia.org/wiki/Drug_interaction
Death of Michael JacksonDeath of Michael Jackson
Other drugs included omeprazole, hydrocodone, paroxetine, carisoprodol, and hydromorphone. After his death, police found ...
https://en.wikipedia.org/wiki/Death_of_Michael_Jackson
Grapefruit-drug interactionsGrapefruit-drug interactions
Omeprazole (Losec, Prilosec) Oxycodone: grapefruit juice enhances the exposure to oral oxycodone. And a randomized, controlled ... Mouly S, Paine MF (August 2001). "Effect of grapefruit juice on the disposition of omeprazole". British Journal of Clinical ...
https://en.wikipedia.org/wiki/Grapefruit–drug_interactions
Vitamin B12Vitamin B12
PPIs examples include omeprazole, lansoprazole, rabeprazole, pantoprazole, and esomeprazole. Clinically significant vitamin B12 ...
https://en.wikipedia.org/wiki/Vitamin_B12
SufotidineSufotidine
Fiorucci S, Santucci L, Farroni F, Pelli MA, Morelli A (October 1989). "Effect of omeprazole on gastroesophageal reflux in ... virtually 24-hour gastric anacidity thus closely resembling the antisecretory effect of the proton pump inhibitor omeprazole. ...
https://en.wikipedia.org/wiki/Sufotidine
RabeprazoleRabeprazole
The side effect profile is similar to that of omeprazole. The most common side effects include headache, nausea, and diarrhea. ... However, because this is thought to be mediated by the effect of omeprazole and esomeprazole on CYP2C19, the enzyme that ... Rabeprazole, like other proton pump inhibitors such as omeprazole, is used for the purposes of gastric acid suppression. This ... In pattern A, a person may be allergic to omeprazole, esomeprazole, and pantoprazole, but not to lansoprazole and rabeprazole. ...
https://en.wikipedia.org/wiki/Rabeprazole
FamotidineFamotidine
omeprazole: a prospective randomized multicentre trial to determine efficacy in non-erosive gastro-oesophageal reflux disease ... Borody TJ, Andrews P, Fracchia G, Brandl S, Shortis NP, Bae H (October 1995). "Omeprazole enhances efficacy of triple therapy ... Escolano F, Castaño J, López R, Bisbe E, Alcón A (October 1992). "Effects of omeprazole, ranitidine, famotidine and placebo on ... although omeprazole may be somewhat more effective. Prevention of NSAID-induced peptic ulcers. Given to surgery patients before ...
https://en.wikipedia.org/wiki/Famotidine
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CS1 maint: discouraged parameter (link) Business Wire (January 23, 2009). "IMPAX Receives Final FDA Approval for Omeprazole 40 ...
https://en.wikipedia.org/wiki/List_of_companies_based_in_Hayward,_California
Krwawienie z przewodu pokarmowego, wolna encyklopediaKrwawienie z przewodu pokarmowego, wolna encyklopedia
Omeprazole before endoscopy in patients with gastrointestinal bleeding. „N Engl J Med". 356 (16), s. 1631-40, Apr 2007. DOI: ...
https://pl.wikipedia.org/wiki/Krwawienie_z_przewodu_pokarmowego
RanitidineRanitidine
... with omeprazole becoming the biggest-selling drug for many years.[citation needed] When omeprazole and ranitidine were compared ... In addition, the omeprazole group reported earlier relief of heartburn symptoms. Preparations of ranitidine products include ... 1996). "Omeprazole as a risk factor for campylobacter gastroenteritis: case-control study". BMJ. 312 (7028): 414-415. doi: ... March 1998). "A comparison of omeprazole with ranitidine for ulcers associated with non-steroidal anti-inflammatory drugs. Acid ...
https://en.wikipedia.org/wiki/Ranitidine
MisoprostolMisoprostol
Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group". The New England Journal of Medicine. ... Hawkey CJ, Karrasch JA, Szczepañski L, Walker DG, Barkun A, Swannell AJ, Yeomans ND (March 1998). "Omeprazole compared with ... omeprazole proved to be at least as effective as misoprostol, but was significantly better tolerated, so misoprostol should not ...
https://en.wikipedia.org/wiki/Misoprostol
Adenosine diphosphate receptor inhibitorAdenosine diphosphate receptor inhibitor
... especially the proton pump inhibitor omeprazole. Omeprazole and clopidogrel are metabolized by the same CYP metabolic pathway. ... Omeprazole is considered to have higher potential for drug-drug interaction than other protein pump inhibitors because it is a ... Various reports have stated that there is a negative clopidogrel-omeprazole drug interaction. Some studies have found that ... Consequently, it has been suggested that the low-responsiveness of clopidogrel, with concomitant use of omeprazole, is caused ...
https://en.wikipedia.org/wiki/Adenosine_diphosphate_receptor_inhibitor
GynecomastiaGynecomastia
... and omeprazole. Certain components of personal skin care products such as lavender essential oil or tea tree oil and certain ...
https://en.wikipedia.org/wiki/Gynecomastia
Proton-pump inhibitorProton-pump inhibitor
a b "Omeprazole and Esomeprazole". Clinical and Research Information on Drug-induced Liver Injury. National Institutes of ... PPIs are among the most widely sold drugs in the world, and the first one, omeprazole, is on the WHO Model List of Essential ... The rate of omeprazole absorption is decreased by concomitant food intake. In addition, the absorption of lansoprazole and ... PPIs were developed in the 1980s with omeprazole being launched in 1988. Most of these drugs are benzimidazole derivatives, ...
https://en.wikipedia.org/wiki/Proton_Pump_Inhibitors
Gastroesophageal reflux diseaseGastroesophageal reflux disease
Initial treatment is frequently with a proton-pump inhibitor such as omeprazole. In some cases, a person with GERD symptoms can ... Proton-pump inhibitors (PPIs), such as omeprazole, are the most effective, followed by H2 receptor blockers, such as ranitidine ...
https://en.wikipedia.org/wiki/Gastroesophageal_reflux_disease
Omeprazole - WikipediaOmeprazole - Wikipedia
Omeprazole is available as tablets and capsules (containing omeprazole or omeprazole magnesium) in strengths of 10, 20, 40, and ... "Omeprazole MSDS". Retrieved October 21, 2018.. *^ "Omeprazole 40 mg Powder for Solution for Infusion". EMC. February 10, 2016. ... "Omeprazole, in The Free Medical Dictionary". Retrieved 11 November 2010.. *^ "Omeprazole". Drugs.com. Archived from the ... the pharmacokinetics of the omeprazole molecule strongly suggest the safety of omeprazole use during breastfeeding: *Omeprazole ...
https://en.wikipedia.org/wiki/Prilosec
Omeprazole: MedlinePlus Drug InformationOmeprazole: MedlinePlus Drug Information
Omeprazole: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking omeprazole,. *tell your doctor and pharmacist if you are allergic to omeprazole, dexlansoprazole (Dexilant), ... Talk to your doctor about the risk of taking omeprazole.. Omeprazole may cause other side effects. Call your doctor if you have ... Do not take nonprescription omeprazole for longer than 14 days or treat yourself with omeprazole more often than once every 4 ...
https://medlineplus.gov/druginfo/meds/a693050.html
Axorid (ketoprofen, omeprazole)Axorid (ketoprofen, omeprazole)
Omeprazole is used to prevent the potential side effects of ketoprofen on the gut. ... ketoprofen and omeprazole. Ketoprofen is a type of medicine called a non-steroidal anti-inflammatory drug (NSAID) and is used ... Omeprazole can reduce the oral absorption of vitamin B12. Omeprazole may reduce the blood levels of ulipristal, a medicine used ... Axorid (ketoprofen, omeprazole). Axorid capsules contain two active ingredients, ketoprofen and omeprazole. Ketoprofen is a ...
https://www.netdoctor.co.uk/medicines/aches-pains/a8742/axorid-ketoprofen-omeprazole/
Aspirin and Omeprazole: MedlinePlus Drug InformationAspirin and Omeprazole: MedlinePlus Drug Information
Aspirin and Omeprazole: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Do not stop taking aspirin and omeprazole without talking to your doctor. If you stop taking aspirin and omeprazole, there is a ... omeprazole, any other medications, or any of the ingredients in the combination of aspirin and omeprazole delayed-release ... Aspirin and omeprazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: * ...
https://medlineplus.gov/druginfo/meds/a617014.html
omeprazole (Prilosec, Zegerid): Side Effects & Dosageomeprazole (Prilosec, Zegerid): Side Effects & Dosage
Consumer information about the OTC and prescription drug omeprazole (Prilosec, Zegerid Prilosec OTC, Zegerid OTC) used for ... Use of omeprazole in pregnant women has not been adequately evaluated. Omeprazole should be used during pregnancy only if the ... Omeprazole should not be used with clopidogrel. Omeprazole increases the concentration of cilostazol (Pletal). The dose of ... omeprazole (Prilosec, Zegerid). *What is omeprazole, and how does it work (mechanism of action)? ...
https://www.medicinenet.com/omeprazole/article.htm
Omeprazole Teva - Drugs.comOmeprazole Teva - Drugs.com
A list of US medications equivalent to Omeprazole Teva is available on the Drugs.com website. ... Omeprazole Teva is a medicine available in a number of countries worldwide. ... Omeprazole Teva may be available in the countries listed below.. Ingredient matches for Omeprazole Teva. Omeprazole. Omeprazole ...
https://www.drugs.com/international/omeprazole-teva.html
Omeprazole - NaturalNews.comOmeprazole - NaturalNews.com
All posts tagged with Omeprazole. * DOUBLE your risk of stomach cancer with acid reflux drugs, study claims. ...
https://www.naturalnews.com/tag/omeprazole/
Prescriber Checkup | OMEPRAZOLEPrescriber Checkup | OMEPRAZOLE
Prescriber Checkup » OMEPRAZOLE OMEPRAZOLE. Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of ...
http://projects.propublica.org/checkup/drugs/3918?by=desc&sort=city
Common and Rare Side Effects for Omeprazole OralCommon and Rare Side Effects for Omeprazole Oral
... infrequent and rare side effects of Omeprazole Oral. ... Omeprazole Side Effects by Likelihood and Severity. COMMON side ...
https://www.webmd.com/drugs/2/drug-3766-2250/omeprazole-oral/omeprazole-delayed-release-tablet-oral/details/list-sideeffects
Quitting Omeprazole - GERD (Acid Reflux) - MedHelpQuitting Omeprazole - GERD (Acid Reflux) - MedHelp
I have been desperately trying to quit Omeprazole for the last 5 years but have had so much problem with extreme acid release ... I cant replace omeprazole with ranitidine, as the latter doesnt seem to work at all. Ive been able to lower the dose to ... if i take omeprazole at least 1/3rd of my rest of my life dont i get any serious consequences like cancer..?? ... Of course noone knows yet the result of taking omeprazole for a lifetime, mice had cancer after weeks but human might as well ...
https://www.medhelp.org/posts/GERD-Acid-Reflux/-Quitting-Omeprazole/show/1111452
omeprazole 40mg - GERD (Acid Reflux) - MedHelpomeprazole 40mg - GERD (Acid Reflux) - MedHelp
Hi everyone I have been prescribed Omeprazole 40mgs is it best to take it first thing in the morning on an empty stomach or in ...
https://www.medhelp.org/posts/GERD-Acid-Reflux/omeprazole-40mg/show/1263334
Omeprazole (Oral Route) Precautions - Mayo ClinicOmeprazole (Oral Route) Precautions - Mayo Clinic
Omeprazole may cause a serious type of allergic reaction when used in patients with conditions treated with antibiotics. Call ... Do not use omeprazole if you are also using medicines containing rilpivirine (Edurant®, Complera®). Using these medicines ... understand about the risks and proper use of any other medicine your doctor gives you or your child together with omeprazole. ...
https://www.mayoclinic.org/drugs-supplements/omeprazole-oral-route/precautions/drg-20066836
Omeprazole 40 mg costOmeprazole 40 mg cost
For example some omeprazole 40 mg cost gaining popularity with a failing sickness tiredness hand. Fish oil is recommended as ... Another way which we give themselves credit omeprazole 40 mg cost usually destroyed by the intrude itself upon her at the time ... Call your doctor at used by women who any problems with your pharmacist to omeprazole 40 mg cost them using Epivir. ... Assimilation of nutritive materials when the bodily temperature the patient omeprazole 40 mg cost taking. ...
https://digilander.libero.it/plussen/md/1607.html
omeprazole | Cignaomeprazole | Cigna
Omeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach ... Omeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus... ... Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. ... Omeprazole is not for immediate relief of heartburn symptoms. Omeprazole may also be used for purposes not listed in this ...
https://www.cigna.com/healthwellness/hw/medications/omeprazole-d00325a1
Carafate (sucralfate) vs. Prilosec (omeprazole): Acid Reflux (GERD) DrugsCarafate (sucralfate) vs. Prilosec (omeprazole): Acid Reflux (GERD) Drugs
Omeprazole is also used to treat Zollinger-Ellison syndrome, duodenitis, erosive esophagitis, heartburn, and H. pylori ... and omeprazole are used to treat ulcers and gastroesophageal reflux disease (GERD). ... Omeprazole. Use of omeprazole in pregnant women has not been adequately evaluated. Omeprazole should be used during pregnancy ... Some versions of omeprazole are available over-the-counter (OTC).. *Carafate and omeprazole belong to different drug classes. ...
https://www.medicinenet.com/carafate_sucralfate_vs_omeprazole_prilosec/article.htm
Angio-edema and urticaria associated with omeprazole. | The BMJAngio-edema and urticaria associated with omeprazole. | The BMJ
Angio-edema and urticaria associated with omeprazole.. BMJ 1992; 305 doi: https://doi.org/10.1136/bmj.305.6858.870-c (Published ...
http://www.bmj.com/content/305/6858/870.4
Signature Care Omeprazole Acid - Online Groceries | SafewaySignature Care Omeprazole Acid - Online Groceries | Safeway
Active Ingredients: In Each Capsule: Omeprazole Magnesium Delayed-Release Capsule (20.6 Mg) (Equivalent to 20 Mg Omeprazole). ... Omeprazole Magnesium, 20.6 mg, Delayed-Realese Capsules. Other Information: Read the directions and warnings before use keep ... Warning Contains: Warnings: Allergy alert: Do not use if you are allergic to omeprazole. Do not use: if you have: trouble or ... Signature Care Omeprazole Acid Reducer Delayed Release 20.6mg Magnesium Capsule - 14 Count. ...
https://www.safeway.com/shop/product-details.960197733.html
Molecular Expressions: The Pharmaceutical Collection - Omeprazole (Prilosec)Molecular Expressions: The Pharmaceutical Collection - Omeprazole (Prilosec)
Omeprazole is a member of a new class of antisecretory compounds termed the substituted benzimidazoles that act by inhibition ... Omeprazole (Prilosec). Omeprazole is a member of a new class of antisecretory compounds termed the substituted benzimidazoles ... Omeprazole is also useful for the treatment and prevention of non-steroidal anti-inflammatory drug (NSAID)-related ...
https://micro.magnet.fsu.edu/pharmaceuticals/pages/prilosec.html
OMEPRAZOLE DR (capsule, delayed release) | Healthgrades.comOMEPRAZOLE DR (capsule, delayed release) | Healthgrades.com
Get an overview of OMEPRAZOLE DR (capsule, delayed release), including warnings and precautions, directions, and the names of ...
https://www.healthgrades.com/drugs/omeprazole-dr
Omeprazole: Side Effects, Dosage, Uses, and MoreOmeprazole: Side Effects, Dosage, Uses, and More
Omeprazole oral capsule is a prescription drug that reduces the amount of acid in your stomach. Its used to treat gastric or ... Side effects from omeprazole: Taking omeprazole with certain medications raises your risk of side effects from omeprazole. This ... Omeprazole also comes as a liquid suspension you take by mouth.. *Omeprazole oral capsule is used to reduce the amount of acid ... What is omeprazole?. Omeprazole oral capsule is a prescription drug thats only available in a generic form. It doesnt have a ...
https://www.healthline.com/health/omeprazole-oral-capsule-sprinkles
Omeprazole: uses & side-effects | PatientsLikeMeOmeprazole: uses & side-effects | PatientsLikeMe
Find the most comprehensive real-world treatment information on Omeprazole at PatientsLikeMe. 1827 patients with fibromyalgia, ... bipolar I disorder or psoriasis currently take Omeprazole. ... 82 patient evaluations for Omeprazole Sort by: Helpfulness * ... Showing 3 of 82 patient evaluations for Omeprazole Previous page 1 2 3 … 28 Next page ...
https://www.patientslikeme.com/treatment/omeprazole?sort=helpfulness
Omeprazole: uses & side-effects | PatientsLikeMeOmeprazole: uses & side-effects | PatientsLikeMe
Find treatment reviews for Omeprazole from other patients. Learn from their experiences about effectiveness, side effects and ... Showing 3 of 90 patient evaluations for Omeprazole Previous page 1 2 3 … 30 Next page ...
https://www.patientslikeme.com/treatment/altosec?page=1&size=3
DailyMed - OMEPRAZOLE capsule, delayed releaseDailyMed - OMEPRAZOLE capsule, delayed release
2. (p , 0.05) omeprazole 40 mg versus 20 mg.. Omeprazole 20 mg Once Daily. (n = 202). Omeprazole 40 mg Once Daily. (n = 214). ... 2. (p , 0.01) omeprazole 40 mg versus 20 mg.. Omeprazole 20 mg Once Daily. (n = 200). Omeprazole 40 mg Once Daily. (n = 187). ... 2. (p = 0.03) omeprazole 10 mg once daily versus Ranitidine.. Omeprazole 20 mg Once Daily. (n = 131). Omeprazole 10 mg Once ... Omeprazole Delayed-Release Capsules, USP (oh mep ra zole) Omeprazole delayed-release capsules. Taking omeprazole delayed- ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=36341291-2d76-47e6-9d61-194ba7f9bd5a&audience=consumer
DailyMed - OMEPRAZOLE capsule, delayed releaseDailyMed - OMEPRAZOLE capsule, delayed release
omeprazole 20 MG Delayed Release Oral Capsule. SCD. 3. 198051. omeprazole (as omeprazole magnesium 20.6 MG) 20 MG Delayed ... omeprazole 10 MG Delayed Release Oral Capsule. SCD. 6. 199119. omeprazole (as omeprazole magnesium) 10 MG Delayed Release Oral ... Omeprazole Delayed-Release Capsules contain an enteric-coated microtablet formulation of omeprazole (because omeprazole is acid ... Dual Therapy - (omeprazole 40 mg once daily/clarithromycin 500 three times daily for 14 days followed by omeprazole 20 mg once ...
https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d58c0b66-475f-46b3-949d-cda5343e7239
Prescriber Checkup | OMEPRAZOLE-SODIUM BICARBONATEPrescriber Checkup | OMEPRAZOLE-SODIUM BICARBONATE
Prescribing data from Medicares prescription drug benefit, known as Part D, was compiled and released by the Centers for Medicare and Medicaid Services, the federal agency that oversees the program. The data for 2016 includes more than 1.5 billion prescriptions written by 1.1 million doctors, nurses and other providers. This database lists over 460,000 of those providers who wrote 50 or more prescriptions for at least one drug that year. More than three-fourths of these prescriptions went to patients 65 and older; the rest were for disabled patients. Methodology ». ...
https://projects.propublica.org/checkup/drugs/5012?by=desc&sort=drug_claims
Help- Omeprazole & Having Heart Pain/Pressure - Gastroenterology - MedHelpHelp- Omeprazole & Having Heart Pain/Pressure - Gastroenterology - MedHelp
I got prescribed Omeprazole 20mg to take twice a day, but I am only taking the tablet once a day because I dont want to have a ... What the heck is going on?? Could the Omeprazole be causing this?? Also has anyone else ever had these side effects with acid ...
https://medhelp.org/posts/Gastroenterology/Help--Omeprazole--Having-Heart-Pain-Pressure/show/2281620
Walgreens Omeprazole Acid Reducer Delayed-Release Tablets | WalgreensWalgreens Omeprazole Acid Reducer Delayed-Release Tablets | Walgreens
Get free shipping at $35 and view promotions and reviews for Walgreens Omeprazole Acid Reducer Delayed-Release Tablets ... Walgreens Omeprazole Acid Reducer Delayed-Release Tablets at Walgreens. ...
https://www.walgreens.com/store/c/walgreens-omeprazole-acid-reducer-tablets/ID=prod3895075-product
Omeprazole and ranitidine | The Scientist Magazine®Omeprazole and ranitidine | The Scientist Magazine®
Previous studies have shown that omeprazole sodium is more effective than ranitidine hydrochloride in controlling symptoms of ... Omeprazole and ranitidine. NEW YORK, July 31 (Praxis Press) Previous studies have shown that omeprazole sodium is more ... Omeprazole provided greater resolution of heartburn symptoms at two and four weeks. Despite omeprazoles higher acquisition ... They found that more omeprazole-treated patients reported improved heartburn resolution at two weeks and four weeks compared ...
https://www.the-scientist.com/?articles.view/articleNo/19912/title/Omeprazole-and-ranitidine/
Omeprazole Liver Side Effects | LIVESTRONG.COMOmeprazole Liver Side Effects | LIVESTRONG.COM
Omeprazole, a drug sold under the brand name is Prilosec, is a medication used to suppress the production of acid in the ... Omeprazole is metabolized in the liver. The liver breaks down omeprazole into products that can easily be removed from the body ... Omeprazole is also used to treat a stomach acid hypersecretory condition known as Zollinger-Ellison syndrome. Omeprazole may ... Omeprazole, a drug sold under the brand name is Prilosec, is a medication used to suppress the production of acid in the ...
https://www.livestrong.com/article/239961-omeprazole-liver-side-effects/
Effects of omeprazole on the antiplatelet activity of clopidogrel. - PubMed - NCBIEffects of omeprazole on the antiplatelet activity of clopidogrel. - PubMed - NCBI
Effects of omeprazole on the antiplatelet activity of clopidogrel.. Yun KH1, Rhee SJ, Park HY, Yoo NJ, Kim NH, Oh SK, Jeong JW. ... Therefore, the aim of the present study was to evaluate the effects of omeprazole, a PPI, on the antiplatelet effect of ... a VerifyNow P2Y12 assay system.The PRU of the omeprazole-treated subjects was significantly higher than that of the omeprazole- ... followed 3 weeks later by the same protocol but with coadministration of 75 mg/day clopidogrel and 20 mg/day omeprazole instead ...
https://www.ncbi.nlm.nih.gov/pubmed/20145345?dopt=Abstract
ClarithromycinCapsulesCapsule20mgTabletsProton-pump inhibSodiumUlcerPrilosec OTCStomach acidRanitidineGERDAbsorptionMagnesiumUlcersLosecLansoprazoleZollinger-EllisonOralAdministration of omeprazoleMedicationSide effectsPantoprazoleDose of omeprazoleEffects of omeprazoleInteract with omeprazoleHelicobacterReceive omeprazoleSlightly soluble in waterImmediate relief of heartburn symptomsMedicationsContinue omeprazoleTake omeprazole with foodTherapyActive ingredientsGastric40mgHeartburn symptomsDetermination of OmeprazolePatientsTreatmentPharmacistDrugSecretionAtazanavirEsomeprazoleSymptomsDecreaseMedicinesDoses of omeprazoleAspirin and omeprazoleAllergic to omeprazole
Clarithromycin19
  • Treatment of a Helicobacter pylori infection can be completed by taking a triple therapy combination of omeprazole, amoxicillin , and clarithromycin for 7-14 days. (wikipedia.org)
  • Refer to the Contraindications section of the prescribing information for clarithromycin and amoxicillin, when administered in combination with omeprazole delayed- release capsules. (nih.gov)
  • If you have an allergy to omeprazole, clarithromycin, and amoxicillin, any penicillin, or any other part of this drug. (mskcc.org)
  • What is the most important information I should know about amoxicillin, clarithromycin, and omeprazole? (cigna.com)
  • Amoxicillin, clarithromycin, and omeprazole is a combination medicine used to prevent stomach ulcer caused by infection with Helicobacter pylori (H. pylori). (cigna.com)
  • What should I discuss with my healthcare provider before taking amoxicillin, clarithromycin, and omeprazole? (cigna.com)
  • You should not breast-feed while taking amoxicillin, clarithromycin, and omeprazole. (cigna.com)
  • When used to treat stomach ulcers caused by H. pylori in adults, the dose of omeprazole is 20 mg twice daily taken with amoxicillin 1,000 mg twice daily and clarithromycin 500 mg twice daily, all for 7 days. (medbroadcast.com)
  • Another dosing regimen for H. pylori infections is omeprazole 20 mg, metronidazole 500 mg, and clarithromycin 250 mg, all twice daily for 7 days. (medbroadcast.com)
  • Omeprazole delayed-release capsules, USP, in combination with clarithromycin and amoxicillin, are indicated for treatment of patients with H. pylori infection and duodenal ulcer disease (active or up to 1-year history) to eradicate H. pylori in adults. (prescriptiondrugs.com)
  • Among patients who fail therapy, omeprazole delayed-release capsules with clarithromycin are more likely to be associated with the development of clarithromycin resistance as compared with triple therapy. (prescriptiondrugs.com)
  • The recommended adult oral regimen is omeprazole delayed-release capsules 20 mg plus clarithromycin 500 mg plus amoxicillin 1000 mg each given twice daily for 10 days. (prescriptiondrugs.com)
  • The recommended adult oral regimen is omeprazole delayed-release capsules 40 mg once daily plus clarithromycin 500 mg three times daily for 14 days. (prescriptiondrugs.com)
  • You should not take this medication if you are allergic to amoxicillin (Amoxil, Augmentin, Moxatag), clarithromycin (Biaxin), omeprazole (Prilosec), or if you have liver disease, or a history of allergic reaction to any antibiotic. (wellspan.org)
  • You should not take colchicine during your treatment with amoxicillin, clarithromycin, and omeprazole, especially if you are an older adult with kidney disease. (wellspan.org)
  • FDA pregnancy category C. It is not known whether amoxicillin, clarithromycin, and omeprazole will harm an unborn baby. (wellspan.org)
  • Do not breast-feed while taking amoxicillin, clarithromycin, and omeprazole. (wellspan.org)
  • How should I take amoxicillin, clarithromycin, and omeprazole? (wellspan.org)
  • Many drugs can interact with amoxicillin, clarithromycin, and omeprazole. (everydayhealth.com)
Capsules18
  • Axorid capsules contain two active ingredients, ketoprofen and omeprazole. (netdoctor.co.uk)
  • Omeprazole is included in Axorid capsules to counteract this effect. (netdoctor.co.uk)
  • Even though Axorid capsules contain omeprazole to try to minimise the side effects of ketoprofen on the gut (for example ulceration, bleeding or perforation of the stomach or intestinal lining), these types of side effects are still possible. (netdoctor.co.uk)
  • These highlights do not include all the information needed to use OMEPRAZOLE DELAYED-RELEASE CAPSULES safely and effectively. (nih.gov)
  • if ulcer present, continue omeprazole delayed-release capsules 20 mg once daily for an additional 18 days. (nih.gov)
  • if ulcer present, continue omeprazole delayed-release capsules 20 mg once daily for an additional 14 days. (nih.gov)
  • Ranbaxy Pharmaceutical announced that under an agreement with AstraZeneca Pharmaceuticals it has launched an authorized generic of Omeprazole 40 mg Capsules in the U.S. healthcare system. (emaxhealth.com)
  • We welcome the opportunity to market an authorized generic of Omeprazole 40 mg capsules that will be commercialized immediately to all classes of trade in the U.S. healthcare system under the Ranbaxy label," said Jim Meehan, Vice President of Sales and Distribution for RPI. (emaxhealth.com)
  • Omeprazole is supplied in 10 and 20 mg capsules. (petplace.com)
  • Omeprazole delayed-release capsules, USP are indicated for short-term treatment of active duodenal ulcer in adults. (prescriptiondrugs.com)
  • Omeprazole delayed-release capsules, USP are indicated for the treatment of heartburn and other symptoms associated with GERD in pediatric patients and adults for up to 4 weeks. (prescriptiondrugs.com)
  • The efficacy of omeprazole delayed-release capsules, USP used for longer than 8 weeks in these patients has not been established. (prescriptiondrugs.com)
  • Omeprazole delayed-release capsules should be taken before eating. (prescriptiondrugs.com)
  • The recommended adult oral dose of omeprazole delayed-release capsules is 20 mg once daily. (prescriptiondrugs.com)
  • In patients with an ulcer present at the time of initiation of therapy, an additional 18 days of omeprazole delayed-release capsules 20 mg once daily is recommended for ulcer healing and symptom relief. (prescriptiondrugs.com)
  • This translates to 304 mg of sodium for each of the Omeprazole capsules. (essaysprofessors.com)
  • Omeprazole has an active ingredient of the delayed release capsules. (essaysprofessors.com)
  • Omeprazole (20 mg) is available as oral delayed-release capsules and oral delayed-release tablets. (pampelmoose.com)
Capsule12
  • Prescription omeprazole comes as a delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) capsule, and packets of delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) granules for suspension (to be mixed with liquid) to take by mouth or give through a feeding tube. (medlineplus.gov)
  • Active Ingredients: In Each Capsule: Omeprazole Magnesium Delayed-Release Capsule (20.6 Mg) (Equivalent to 20 Mg Omeprazole). (safeway.com)
  • Omeprazole oral capsule is used to reduce the amount of acid in your stomach. (healthline.com)
  • Omeprazole oral capsule is a prescription drug that's only available in a generic form. (healthline.com)
  • Prescription omeprazole oral capsule is a delayed-release drug. (healthline.com)
  • Omeprazole oral capsule doesn't cause drowsiness. (healthline.com)
  • Omeprazole oral capsule can interact with other medications, vitamins, or herbs you may be taking. (healthline.com)
  • Each capsule contains either 40 mg or 20 mg of omeprazole and 1100 mg of sodium bicarbonate with the following excipients: croscarmellose sodium and sodium stearyl fumarate. (rxlist.com)
  • ZEGERID (omeprazole/sodium bicarbonate) is available as a capsule and as a powder for oral suspension in 20 mg and 40 mg strengths of omeprazole for adult use. (rxlist.com)
  • Each size '3', pink/pink, hard gelatin capsule filled with white-to-off-white granules covered with a gastro-resistant coating, imprinted with 'E' on pink cap and '65' on pink body with black ink, contains 10 mg of omeprazole. (medbroadcast.com)
  • Patients should be informed that the omeprazole delayed-release capsule should be swallowed whole. (prescriptiondrugs.com)
  • In this article, the author provides suggestions for administering omeprazole to a patient who cannot swallow the capsule whole or who has a nasogastric or gastrostomy tube or a jejunostomy tube. (ijpc.com)
20mg5
  • I got prescribed Omeprazole 20mg to take twice a day, but I am only taking the tablet once a day because I don't want to have a horrible repeat attack (like I had last time I took it daily for a month) when I have to stop the medication. (medhelp.org)
  • Doctor prescribed Omeprazole 20mg once a day for one year. (webmd.com)
  • Buspirone 5mg used QID a day after meal plus 20mg omeprazole before breakfast. (clinicaltrials.gov)
  • Omeprazole is currently only available from HealthExpress as dosages of 10mg and 20mg. (healthexpress.co.uk)
  • And should 20mg of Omeprazole (Prilosec) be enough for me? (healingwell.com)
Tablets6
  • tell your doctor and pharmacist if you are allergic to aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, others) and indomethacin (Indocin), omeprazole, any other medications, or any of the ingredients in the combination of aspirin and omeprazole delayed-release tablets. (medlineplus.gov)
  • For maximal efficacy, omeprazole tablets should be taken before meals, swallowed whole and should not be crushed, chewed or opened. (medicinenet.com)
  • Can you use antiacid tablets if needed along with Omeprazole? (emaxhealth.com)
  • Enter an amazing little tablet called Omeprazole Orally Disintegrating Tablets, or Omeprazole ODT . (brobible.com)
  • Additionally, if you've never taken disintegrating tablets, be sure you don't chew Omeprazole ODT or take it with water. (brobible.com)
  • Two Omeprazole tablets (20 mg Omeprazole) were separately crushed with a mortar and pestle and transferred to two 100 mL volumetric flasks. (waters.com)
Proton-pump inhib7
  • Omeprazole is in a class of medications called proton-pump inhibitors. (medlineplus.gov)
  • Omeprazole is in a class of drugs called proton pump inhibitors (PPI) that block the production of acid by the stomach. (medicinenet.com)
  • Omeprazole, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. (medicinenet.com)
  • Omeprazole belongs to a class of drugs called proton pump inhibitors (PPIs) . (healthline.com)
  • Omeprazole belongs to the family of medications called proton pump inhibitors (PPIs). (medbroadcast.com)
  • Omeprazole is a drug that belongs to proton pump inhibitors. (essaysprofessors.com)
  • Proton-pump inhibitors, such as omeprazole, are widely used in the prevention and treatment of gastroesophageal diseases. (sigmaaldrich.com)
Sodium13
  • Zegerid contains omeprazole and an antacid ( sodium bicarbonate ). (medicinenet.com)
  • NEW YORK, July 31 (Praxis Press) Previous studies have shown that omeprazole sodium is more effective than ranitidine hydrochloride in controlling symptoms of heartburn in patients with gastroesophageal reflux disease (GERD). (the-scientist.com)
  • To compare the two medications, Kaplan-Machlis and colleagues performed a multicenter, randomized, open-label, medical effectiveness trial in 268 patients with GERD randomly assigned to receive omeprazole sodium or ranitidine hydrochloride for up to 6 months. (the-scientist.com)
  • Read the side effects of Omeprazole and Sodium Bicarbonate as described in the medical literature. (medindia.net)
  • ZEGERID® (omeprazole/sodium bicarbonate) is a combination of omeprazole, a proton-pump inhibitor, and sodium bicarbonate, an antacid. (rxlist.com)
  • What are the possible side effects of omeprazole and sodium bicarbonate (Zegerid, Zegerid OTC)? (rxlist.com)
  • ZEGERID (omeprazole/sodium bicarbonate ) is indicated for short-term treatment of active duodenal ulcer . (rxlist.com)
  • These figures denote the amount of the active ingredient, omeprazole sodium. (healthexpress.co.uk)
  • Omeprazole contains 20 mg of Omeprazole as its active ingredient, while Pantoprazole contains 40 mg of Pantoprazole sodium as its active ingredient. (pampelmoose.com)
  • Who should not take omeprazole and sodium bicarbonate? (sharecare.com)
  • You should not take omeprazole-sodium bicarbonate if you know you are allergic to either of these medications. (sharecare.com)
  • children under 18 years of age should not take omeprazole-sodium bicarbonate. (sharecare.com)
  • Women who are pregnant or breast-feeding also should not take omeprazole-sodium bicarbonate. (sharecare.com)
Ulcer13
  • Omeprazole , sold under the brand names Prilosec and Losec among others, is a medication used in the treatment of gastroesophageal reflux disease , peptic ulcer disease , and Zollinger-Ellison syndrome . (wikipedia.org)
  • The combination of aspirin and omeprazole is used to reduce the risk of stroke or heart attack in patients who have had or are at risk of these conditions and are also at risk of developing a stomach ulcer when taking aspirin. (medlineplus.gov)
  • Omeprazole may also be given together with antibiotics to treat gastric ulcer caused by infection with helicobacter pylori (H. pylori). (cigna.com)
  • Carafate is an anti-ulcer drug and omeprazole is a proton pump inhibitor (PPI). (medicinenet.com)
  • Omeprazole is also useful for the treatment and prevention of non-steroidal anti-inflammatory drug (NSAID)-related gastroduodenal disease and peptic ulcer disease. (fsu.edu)
  • Omeprazole 40 mg is indicated for the treatment of acid-related disease, including gastric ulcer and Zollinger-Ellison syndrome. (emaxhealth.com)
  • L-tryptophan in combination with the ulcer medication omeprazole improves ulcer healing rates compared to taking omeprazole alone. (nih.gov)
  • Omeprazole promotes ulcer healing in animals with ulcers or erosions (shallow depressions in the stomach lining). (petplace.com)
  • If your ulcer continues to bother you, your doctor may suggest that you continue taking omeprazole for a period of time to make sure that your ulcer is fully healed. (medbroadcast.com)
  • In 1988, Swedish company Astra (now known as AstraZeneca) developed a new anti-ulcer drug - proton pump inhibitor Omeprazole (trade name: Losec). (researchandmarkets.com)
  • Omeprazole, able to inhibit gastric acid secretion and relieve gastralgia, gastrectasia and other symptoms in a short period of time, became popular among ulcer patients immediately after it was marketed. (researchandmarkets.com)
  • Although there are many anti-ulcer drugs on the market, because of good effects, Omeprazole stands out from its many competitors and secures its leading role. (researchandmarkets.com)
  • Omeprazole, a proton pump inhibitor indicated for peptic ulcer disease, reflux esophagitis and hypersecretory conditions, is known to be inactivated by gastric acidity. (ijpc.com)
Prilosec OTC1
  • While lansoprazole falls under the brand names of Prevacid, Prevacid OTC, Prevacid SoluTab and Prevacid I.V., omeprazole commonly comes as FIRST Omeprazole, PriLOSEC, PriLOSEC OTC and Zegerid. (reference.com)
Stomach acid5
  • [1] Omeprazole is a proton-pump inhibitor and as such blocks the release of stomach acid. (wikipedia.org)
  • Omeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. (cigna.com)
  • Omeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). (cigna.com)
  • Omeprazole is also used to treat a stomach acid hypersecretory condition known as Zollinger-Ellison syndrome. (livestrong.com)
  • Omeprazole inhibits the movement of hydrogen ions - a constituent of hydrochloric stomach acid. (petplace.com)
Ranitidine7
  • I can't replace omeprazole with ranitidine, as the latter doesn't seem to work at all. (medhelp.org)
  • They found that more omeprazole-treated patients reported improved heartburn resolution at two weeks and four weeks compared with ranitidine-treated patients. (the-scientist.com)
  • The administration of oral omeprazole to a 41-year-old female during the third trimester of pregnancy, after ranitidine and cisapride failed to control her refractory gastroesophageal reflux, is reported. (hindawi.com)
  • Usually when omeprazole does not work, ranitidine is tried in its place. (healthboards.com)
  • This study compares the efficacyof omeprazole to ranitidine for this indication. (springer.com)
  • Sixty-seven high-risk patients were randomized toreceive either ranitidine 150 mg (N = 35) intravenouslydaily or omeprazole 40 mg (N = 32) daily orally or by nasogastric route. (springer.com)
  • The projectile vomit and inhaling vomit in lungs kind of reflux and were were given lansoprazole (very similar to omeprazole) and and ranitidine it didn't make any difference or to be clear. (mumsnet.com)
GERD10
  • Omeprazole can be used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcers , erosive esophagitis , Zollinger-Ellison syndrome , and eosinophilic esophagitis . (wikipedia.org)
  • Prescription omeprazole is used alone or with other medications to treat the symptoms of gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus (the tube between the throat and stomach) in adults and children 1 year of age and older. (medlineplus.gov)
  • Prescription omeprazole is used to treat damage from GERD in adults and children 1 month of age and older. (medlineplus.gov)
  • Prescription omeprazole is used to allow the esophagus to heal and prevent further damage to the esophagus in adults and children 1 year of age and older with GERD. (medlineplus.gov)
  • Carafate ( sucralfate ) and omeprazole are used to treat ulcers and gastroesophageal reflux disease ( GERD ). (medicinenet.com)
  • Omeprazole is a proton pump inhibitor (PPI) that blocks the production of acid by the stomach used to treat ulcers, gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, duodenitis, erosive esophagitis, heartburn, and H. pylori infection. (medicinenet.com)
  • Prilosec is the brand name of the drug omeprazole, which is used to treat symptoms of gastroesophageal reflux disease (GERD) . (everydayhealth.com)
  • If there is recurrence of erosive esophagitis or GERD symptoms (eg, heartburn), additional 4 to 8 week courses of omeprazole may be considered. (prescriptiondrugs.com)
  • Omeprazole oral suspension has been used to treat gastrointestinal problems, especially gastroesophageal reflux disease (GERD) in pediatric patients and newborns. (uspharmacist.com)
  • Omeprazole is a proton pump inhibitor that is used to treat gastrointestinal problems, especially GERD, which is common in pediatric patients and also occurs in newborns. (uspharmacist.com)
Absorption9
  • Therefore, omeprazole as well as other PPIs reduce the absorption and concentration in blood of ketoconazole ( Nizoral ) and increase the absorption and concentration in blood of digoxin ( Lanoxin ). (medicinenet.com)
  • Does Omeprazole Decrease Intestinal Calcium Absorption? (clinicaltrials.gov)
  • The purpose of this study is to measure the effect of omeprazole on intestinal calcium absorption in postmenopausal women. (clinicaltrials.gov)
  • The primary study outcome is the change in intestinal calcium absorption following omeprazole therapy 40 mg daily for 30 days. (clinicaltrials.gov)
  • The first 2 studies will determine the monthly variation in calcium absorption, while the 3rd study will occur after taking 40 mg of omeprazole daily for 30 days. (clinicaltrials.gov)
  • In a study of elderly women, administration of omeprazole decreased the absorption of calcium, presumably because the drug decreased the stomach's production of hydrochloric acid, which is necessary for calcium absorption. (adventisthealthcare.com)
  • Due to this, Omeprazole administration checks the absorption and the blood concentration of ketoconazole or Nizoral and raises the absorption and concentration of Digoxin also known as Lanoxin in blood plasma. (essaysprofessors.com)
  • Absorption of Omeprazole takes place in the small intestines (Hochwald & Farrington, 2006). (essaysprofessors.com)
  • Marcuard and coworkers [1] have failed to show that omeprazole therapy causes the apparent changes in cyanocobalamin absorption. (annals.org)
Magnesium4
  • Each pink, circular, biconvex, film-coated tablet contains omeprazole magnesium anhydrous 10.3 mg equivalent to omeprazole 10 mg. (medbroadcast.com)
  • We are one of the leading manufacturer, supplier and exporter of Omeprazole Magnesium in Hyderabad. (tradeindia.com)
  • We are instrumental in offering Omeprazole Magnesium. (tradeindia.com)
  • We are a leading company, involved in manufacturing and exporting a premium quality range of Omeprazole Magnesium. (tradeindia.com)
Ulcers13
  • Peptic ulcers may be treated with omeprazole. (wikipedia.org)
  • Prescription omeprazole is also used to treat ulcers (sores in the lining of the stomach or intestine) and it is also used with other medications to treat and prevent the return of ulcers caused by a certain type of bacteria ( H. pylori ) in adults. (medlineplus.gov)
  • Omeprazole is classified as a proton pump inhibitor and is indicated for the treatment of frequent heartburn due to gastroesophageal disease and for the treatment of gastric and duodenal ulcers. (livestrong.com)
  • OMEPRAZOLE is used in people who have had heart problems or strokes caused by blood clots to help reduce their risk of further heart problems or strokes and in people who are at risk of developing stomach ulcers with aspirin. (nationwidechildrens.org)
  • Omeprazole, commonly known by the brand name Prilosec®, is used in the treatment and prevention of stomach (gastric) and intestinal ulcers in dogs and cats . (petplace.com)
  • Omeprazole is such a drug and has been used for the treatment and prevention of stomach ulcers. (petplace.com)
  • Omeprazole is used in the treatment and prevention of stomach (gastric) and intestinal ulcers. (petplace.com)
  • Omeprazole may be useful in treatment of ulcers caused by ulcerogenic drugs (such as aspirin). (petplace.com)
  • Omeprazole is used to treat conditions where reduction in acid secretion is required for proper healing, including stomach and intestinal ulcers (gastric and duodenal ulcers), the prevention and treatment of ulcers associated with medications known as NSAIDs, reflux esophagitis, Zollinger-Ellison syndrome, heartburn, and gastroesophageal reflux disease (GERD). (medbroadcast.com)
  • When treating Zollinger-Ellison syndrome , the dose of omeprazole varies, but is often higher than the doses used to treat ulcers. (medbroadcast.com)
  • The omeprazole in this combination medicine helps reduce the risk of stomach ulcers that may be caused by aspirin, especially in people who are 55 or older, or those who have had stomach ulcers in the past. (wellspan.org)
  • The administration of Omeprazole at par with other relative antibiotics is able to treat the gastric ulcers that are because of the infections that are caused by Helicobacter pylori. (essaysprofessors.com)
  • In patients with bleeding peptic ulcers and signs of recent bleeding, treatment with omeprazole decreases the rate of further bleeding and the need for surgery. (nih.gov)
Losec2
  • Losec (Omeprazole) is a widely-used treatment for indigestion and acid reflux. (mypharmacy.co.uk)
  • Losec (Omeprazole) is a proton pump inhibitor (PPI). (mypharmacy.co.uk)
Lansoprazole6
  • What Is the Difference Between Lansoprazole and Omeprazole? (reference.com)
  • Drugs.com indicates a difference in brand names for lansoprazole and omeprazole as well as a difference in who may safely take each drug based on health conditions and possible drug interactions. (reference.com)
  • Drugs.com also notes differences in who may or may not take lansoprazole or omeprazole. (reference.com)
  • For instance, the site explains that people who have an electrolyte imbalance or metabolic disorder must not take lansoprazole but makes no such indication for omeprazole. (reference.com)
  • Drugs.com also lists osteoporosis, or low bone mineral density, as a condition under which to avoid omeprazole but does not mention this with regard to lansoprazole. (reference.com)
  • People who have allergies to omeprazole or any other benzimidazole medications, such as albendazole or mebendazole, must not take omeprazole, but Drugs.com does not make this indication with lansoprazole. (reference.com)
Zollinger-Ellison2
  • Prescription omeprazole is also used to treat conditions in which the stomach produces too much acid such as Zollinger-Ellison syndrome in adults. (medlineplus.gov)
  • Omeprazole is also used to treat Zollinger-Ellison syndrome, duodenitis, erosive esophagitis , heartburn , and H. pylori infection. (medicinenet.com)
Oral9
  • Omeprazole is also available as an oral suspension and comes as an over-the-counter (OTC) medication. (healthline.com)
  • Read user comments about the side effects, benefits, and effectiveness of omeprazole oral. (webmd.com)
  • We conclude that oral omeprazole is safe,effective, and clinically feasible for stress ulcerprophylaxis. (springer.com)
  • A formulation for preparing Omeprazole 2-mg/mL Oral Liquid. (ijpc.com)
  • The oral suspension Omeprazole half-life is dependent on the pH reading. (essaysprofessors.com)
  • The concentrations of Omeprazole in serum are between ranges of 0.23 to 1.2 mg/L. This is measured in patients who receive the drug via the oral route. (essaysprofessors.com)
  • Omeprazole Oral Suspension USP at a concentration of 2 mg/mL is an official USP compounded preparation. (uspharmacist.com)
  • The omeprazole granules and inactive granules are constituted with water to form a suspension and are given by oral, nasogastric, or direct gastric administration. (uspharmacist.com)
  • Oral activated charcoal is 10mM and acts as the malignant disease and can you mix omeprazole and tums serotonin -receptor antagonists. (musicaenlamochila.net)
Administration of omeprazole2
  • Administration of Omeprazole checks the effects of the enzymes and has the potential of clopidogrel activity reduction. (essaysprofessors.com)
  • Marcuard and associates [1] have actually compared the change from baseline between two groups of patients, each receiving the same interventions, including daily administration of omeprazole, but at a dose of 20 mg or 40 mg. (annals.org)
Medication8
  • The combination of aspirin and omeprazole comes as a delayed-release tablet (releases the medication in the intestine to prevent damage to the stomach) to take by mouth. (medlineplus.gov)
  • Your doctor will probably tell you not to take aspirin and omeprazole if you are taking this medication. (medlineplus.gov)
  • My question is that does taking omeprazole otc instead of prescription prilose make any difference in efficacy of the medication. (medhelp.org)
  • Omeprazole may also be used for purposes not listed in this medication guide. (cigna.com)
  • Omeprazole, a drug sold under the brand name is Prilosec, is a medication used to suppress the production of acid in the stomach. (livestrong.com)
  • Thanks to the tablet's MELTech formula, I can simply take Omeprazole ODT whenever and wherever - I don't even need to have a drink to comfortably take the medication. (brobible.com)
  • Do not take this medication if you are allergic to omeprazole or any ingredients of the medication. (medbroadcast.com)
  • Aspirin and omeprazole may also be used for purposes not listed in this medication guide. (wellspan.org)
Side effects6
  • Omeprazole is used to prevent the potential side effects of ketoprofen on the gut. (netdoctor.co.uk)
  • What are the side effects of omeprazole? (medicinenet.com)
  • Side effects of Carafate and omeprazole that are similar include headache , dizziness , diarrhea , nausea , and vomiting . (medicinenet.com)
  • Side effects of Carafate that are different from omeprazole include constipation , trouble sleeping ( insomnia ), spinning sensation ( vertigo ), indigestion , dry mouth , dizziness , and gas . (medicinenet.com)
  • Side effects of omeprazole that are different from Carafate include rash , nervousness, abnormal heartbeat, muscle pain , and weakness . (medicinenet.com)
  • While generally safe and effective when prescribed by a veterinarian, omeprazole can cause side effects in some animals. (petplace.com)
Pantoprazole8
  • Which is Better Omeprazole or Pantoprazole? (pampelmoose.com)
  • Omeprazole and Pantoprazole are two common drugs recommended for treating acid influx. (pampelmoose.com)
  • Unlike Omeprazole, Pantoprazole is available only on prescription. (pampelmoose.com)
  • Because Omeprazole and Pantoprazole belong to the same class of drugs (proton pump inhibitor) they work in a similar fashion. (pampelmoose.com)
  • Firstly, because Pantoprazole can be administered through injections, it works faster than Omeprazole which needs to go through the stomach, intestine, the coating also has to dissolve before it can be absorbed. (pampelmoose.com)
  • Pantoprazole is slightly more acid-stable than omeprazole. (pampelmoose.com)
  • Omeprazole has a longer half-life (90 minutes) than Pantoprazole (60 minutes), so the effects of Omeprazole should last longer. (pampelmoose.com)
  • Omeprazole interacts with more drugs (342 known) than Pantoprazole (259). (pampelmoose.com)
Dose of omeprazole3
  • The higher the dose of omeprazole, the less vitamin B-12 you are able to absorb. (livestrong.com)
  • The usual recommended dose of omeprazole is 10 mg to 40 mg once daily. (medbroadcast.com)
  • With the exception of one patient who had persistent nausea and was withdrawn from the study, all the adverse events resolved spontaneously during continued treatment with the same dose of omeprazole. (bmj.com)
Effects of omeprazole4
  • Long term effects of omeprazole have not been rigorously studied, however it is known that there are physical changes to the cells in your stomach with prolonged use. (medhelp.org)
  • Effects of omeprazole on the antiplatelet activity of clopidogrel. (nih.gov)
  • Therefore, the aim of the present study was to evaluate the effects of omeprazole, a PPI, on the antiplatelet effect of clopidogrel.We divided 20 healthy volunteers into 2 groups (n = 10 each). (nih.gov)
  • The aim of the present study was to elucidate the influence of omeprazole on bone and investigate whether dietary 2-oxoglutarate supplementation could prevent the effects of omeprazole. (sigmaaldrich.com)
Interact with omeprazole2
  • Which drugs or supplements interact with omeprazole? (medicinenet.com)
  • Consult with your veterinarian to determine if other drugs your pet is receiving could interact with omeprazole. (petplace.com)
Helicobacter1
  • 12. A method for the treatment of Helicobacter infections and diseases which comprises administration of a therapeutically effective amount of omeprazole form A according to claim 1 to a patient in need thereof. (patentgenius.com)
Receive omeprazole1
  • The patients were randomly assigned to receive omeprazole (40 mg given orally every 12 hours for five days) or placebo. (nih.gov)
Slightly soluble in water1
  • Omeprazole is a white to off-white crystalline powder which melts with decomposition at about 155°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. (rxlist.com)
Immediate relief of heartburn symptoms2
  • Do not take nonprescription omeprazole for immediate relief of heartburn symptoms. (medlineplus.gov)
  • Omeprazole is not for immediate relief of heartburn symptoms. (cigna.com)
Medications3
  • Drugs.com only lists clopidogrel and HIV or AIDS medications, such as atazanavir, nelfinavir and rilpivirine, as having possible interactions with omeprazole. (reference.com)
  • Omeprazole is a proton-pump inhibitor most often used (either on its own or in combination with other medications) to treat acid reflux. (healthexpress.co.uk)
  • I live in Buenos Aires, Argentina and it is common for doctors to prescribe Omeprazole, especially when taking many medications. (thebody.com)
Continue omeprazole1
  • No adverse fetal effects were apparent, and the patient elected to continue omeprazole therapy (20 mg/day) while breastfeeding. (hindawi.com)
Take omeprazole with food2
  • The mortality can you take omeprazole with food in renal and require invasive salmonella. (imagenenaccion.org)
  • Fludrocortisone is distributed to an can you take omeprazole with food advantage for vascular disease include noc- turia, which inhibits its drug-sensitive companions. (imagenenaccion.org)
Therapy3
  • Consequently, omeprazole reduces the antiplatelet effect of clopidogrel, suggesting that careful treatment planning is required when administering omeprazole to patients on clopidogrel therapy. (nih.gov)
  • Although omeprazole is a potentially useful therapy for refractory gastroesophageal reflux during pregnancy and lactation, further data are needed to define better its safety and efficacy. (hindawi.com)
  • Overtreatment may result in craniosynostosis in infants and omeprazole and levothyroxine taken together closure of Seizures have been reported rarely with the institution of levothyroxine therapy. (soxanddawgs.com)
Active ingredients1
  • Active Ingredients: In Each Tablet: Omeprazole (20 mg). (randalls.com)
Gastric4
  • Omeprazole is a member of a new class of antisecretory compounds termed the substituted benzimidazoles that act by inhibition of the H+/K+ ATPase enzyme system at the secretory surface of gastric parietal cells. (fsu.edu)
  • In long-term (2-year) studies in rats, omeprazole produced a dose-related increase in gastric carcinoid tumors. (medindia.net)
  • Omeprazole is a substituted benzimidazole, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, a racemic mixture of two enantiomers that inhibits gastric acid secretion. (rxlist.com)
  • 10. A method for inhibiting gastric acid secretion which comprises administration of a therapeutically effective amount of omeprazole form A according to claim 1 to a patient in need thereof. (patentgenius.com)
40mg1
Heartburn symptoms1
  • Omeprazole provided greater resolution of heartburn symptoms at two and four weeks. (the-scientist.com)
Determination of Omeprazole1
  • Enantioselective high performance liquid chromatographic determination of omeprazole in humanplasma", pp. 323-328 (1995). (patentgenius.com)
Patients8
  • Through unknown mechanisms, omeprazole may increase blood levels of saquinavir and reduce blood levels of nelfinavir and atazanavir , drugs that are used for treating patients with infection caused by the human immunodeficiency virus ( HIV ). (medicinenet.com)
  • Omeprazole may cause a serious type of allergic reaction when used in patients with conditions treated with antibiotics. (mayoclinic.org)
  • Some patients may experience immediate acute liver failure after taking omeprazole. (livestrong.com)
  • Separating the omeprazole by 12 hours from the atazanvir and using the 20 mg/day max may allow the drugs to be used with some confidence in the same patients. (thebody.com)
  • In a preliminary study to compare the effects of different doses of omeprazole 44 patients with endoscopically diagnosed duodenal ulceration randomly received omeprazole 20 mg, 30 mg, 40 mg, or 60 mg daily for four weeks. (bmj.com)
  • Thus, it is advisable that patients are supposed to take Omeprazole on an empty stomach using a glass of water. (essaysprofessors.com)
  • Two patients in the omeprazole group and six in the placebo group died. (nih.gov)
  • A subgroup analysis showed that omeprazole was associated with significant reductions in recurrent bleeding and surgery in patients with nonbleeding, visible vessels or adherent clots, but not in those with arterial spurting or oozing. (nih.gov)
Treatment5
  • The percentage inhibition showed a decrease after the 14-day omeprazole treatment (22.7 +/- 29.9% versus 35.1 +/- 18.7%, P = 0.014). (nih.gov)
  • Treatment of healthy volunteers with omeprazole for four weeks resulted in a 12.3% decrease in blood levels of vitamin C. (adventisthealthcare.com)
  • Omeprazole is a basic compound which acts as a proton pump inhibitor used in the treatment of acid reflux and heartburn. (waters.com)
  • Omeprazole treatment exerts its effects mostly on bone mineralization and cancellous bone, adversely affecting bone properties. (sigmaaldrich.com)
  • can you mix omeprazole and tums Sulphonylureas are receiving cytotoxic therapies because of treatment of bladder and treatment It is depleted. (musicaenlamochila.net)
Pharmacist2
  • Call your doctor at used by women who any problems with your pharmacist to omeprazole 40 mg cost them using Epivir. (libero.it)
  • If instructed to take any of these drugs while taking omeprazole, consult your doctor or pharmacist regarding the proper timing of each dose. (patientassistance.com)
Drug5
  • Is omeprazole available as a generic drug? (medicinenet.com)
  • Carafate and omeprazole belong to different drug classes. (medicinenet.com)
  • If you take omeprazole to control acid reflux, you should be aware that the drug interferes with your body's ability to absorb vitamin B-12. (livestrong.com)
  • Omeprazole is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian. (petplace.com)
  • Omeprazole should not be used in animals with known hypersensitivity or allergy to the drug. (petplace.com)
Secretion2
  • Peak omeprazole concentrations in breast milk (58 nM, 3 h after ingestion) were less than 7% of the peak serum concentration (950 nM at 4 h), indicating minimal secretion. (hindawi.com)
  • Through this effect, omeprazole blocks acid secretion in the stomach. (petplace.com)
Atazanavir3
  • I understand that there is a major interaction between Atazanavir and Omeprazole. (thebody.com)
  • There is concern that the reduced stoamch acid from the omeprazole will decrease the absorptio/blood levels/effectiveness of the atazanavir . (thebody.com)
  • There are chances too that, Omeprazole administration, is able to raise the blood levels of Saquinavir as well as checking the levels of Nelfinaivir and Atazanavir in the blood plasma. (essaysprofessors.com)
Esomeprazole1
  • It is also reasonable to distinguish Esomeprazole from the Racemic Omeprazole. (essaysprofessors.com)
Symptoms4
  • Do not take the combination of aspirin and omeprazole to treat sudden signs and symptoms of a heart attack or stroke. (medlineplus.gov)
  • Omeprazole may cause new or worsening symptoms of lupus . (rxlist.com)
  • Aspirin and omeprazole should not be used to treat a sudden onset of heart attack or stroke symptoms, such as: chest pain spreading to your jaw or shoulder, sudden numbness or weakness (especially on one side of the body), slurred speech, problems with vision or balance. (wellspan.org)
  • I've also tried to change my diet to eat more healthily and have been taking probiotic drinks (as well as some spoons of Gaviscon from time to time to supplement the omeprazole) but nothing seems to be able to get rid of the symptoms. (healingwell.com)
Decrease1
  • Potent acid-reducing medicines such as omeprazole can decrease the effectiveness of sucralfate, as well as other drugs such as the antifungals ketoconazole and itraconazole. (patientassistance.com)
Medicines1
  • Erythrocin Ery Tab) pentamidine (NebuPent Pentam) sparfloxacin (Zagam) or telithromycin (Ketek) antidepressants such as amitriptyline (Elavil Etrafon) clomipramine (Anafranil) imipramine diarrhea Liver and Biliary medicines to treat psychiatric disorders such as chlorpromazine (Thorazine) haloperidol (Haldol) mesoridazine (Serentil) pimozide (Orap) or thioridazine omeprazole 40 mg cost or heart rhythm medicine such as amiodarone (Cordarone Pacerone) dofetilide (Tikosyn) disopyramide (Norpace) procainamide was reported in 2 Quinaglute) or sotalol (Betapace). (libero.it)
Doses of omeprazole1
  • If high doses of omeprazole are given for long periods of time, for example to people with Zollinger-Ellis disease, there is a risk for developing vitamin B-12 deficiency. (livestrong.com)
Aspirin and omeprazole15
  • Take the combination of aspirin and omeprazole at around the same time every day. (medlineplus.gov)
  • Take the combination of aspirin and omeprazole exactly as directed. (medlineplus.gov)
  • Continue to take aspirin and omeprazole even if you feel well. (medlineplus.gov)
  • Do not stop taking aspirin and omeprazole without talking to your doctor. (medlineplus.gov)
  • If you stop taking aspirin and omeprazole, there is a higher risk that you may have a heart attack or stroke. (medlineplus.gov)
  • Your doctor may tell you that you should not take aspirin and omeprazole if you have any of these conditions. (medlineplus.gov)
  • What is the most important information I should know about aspirin and omeprazole? (wellspan.org)
  • Aspirin and omeprazole is a combination medicine used to help lower the risk of heart problems, strokes, or death in people who have had certain conditions related to blood clots, including angina (chest pain), a past heart attack, or a stroke or a "mini stroke. (wellspan.org)
  • Aspirin and omeprazole is also used in people who have had surgery to improve blood flow to the heart and also have another condition that is already being treated with aspirin. (wellspan.org)
  • Taking regular aspirin together with omeprazole (Prilosec) will not work the same way as taking combination aspirin and omeprazole (Yosprala). (wellspan.org)
  • What should I discuss with my healthcare provider before taking aspirin and omeprazole? (wellspan.org)
  • Tell your doctor if you are pregnant or plan to become pregnant while taking aspirin and omeprazole. (wellspan.org)
  • Aspirin and omeprazole can pass into breast milk and may harm a nursing baby. (wellspan.org)
  • How should I take aspirin and omeprazole? (wellspan.org)
  • Aspirin and omeprazole is usually taken once per day, at least 60 minutes before a meal. (wellspan.org)
Allergic to omeprazole2
  • You should not use this medicine if you are allergic to omeprazole or to any benzimidazole medicine such as albendazole or mebendazole. (cigna.com)
  • Warning Contains: Warnings: Allergy alert: Do not use if you are allergic to omeprazole. (safeway.com)
Walgreens Omeprazole Acid Reducer Delayed-Release Tablets | Walgreens
Walgreens Omeprazole Acid Reducer Delayed-Release Tablets | Walgreens (walgreens.com)
OMEPRAZOLE DR (capsule, delayed release) | Side Effects, Adverse Reactions | Healthgrades.com
OMEPRAZOLE DR (capsule, delayed release) | Side Effects, Adverse Reactions | Healthgrades.com (healthgrades.com)
PLOS ONE: Omeprazole Blocks STAT6 Binding to the Eotaxin-3 Promoter in Eosinophilic Esophagitis Cells
PLOS ONE: Omeprazole Blocks STAT6 Binding to the Eotaxin-3 Promoter in Eosinophilic Esophagitis Cells (journals.plos.org)
Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms
Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms (journals.plos.org)
Plavix cost, Omeprazole and plavix interaction 2015
Plavix cost, Omeprazole and plavix interaction 2015 (bitbot.com.au)
Omeprazole - Wikipedia
Omeprazole - Wikipedia (en.wikipedia.org)
Rate your experience with this treatment
Rate your experience with this treatment (webmd.com)
Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors: An Update | SpringerLink
Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors: An Update | SpringerLink (link.springer.com)
Molecular Expressions: The Pharmaceutical Collection - Omeprazole (Prilosec)
Molecular Expressions: The Pharmaceutical Collection - Omeprazole (Prilosec) (micro.magnet.fsu.edu)
Peptic Ulcer Disease Medication: Proton Pump Inhibitors, H2 Receptor Blockers, Antimicrobials, Antidiarrheal Agents,...
Peptic Ulcer Disease Medication: Proton Pump Inhibitors, H2 Receptor Blockers, Antimicrobials, Antidiarrheal Agents,... (emedicine.medscape.com)
Pediatric Gastroesophageal Reflux Medication: Antacids, Histamine H2 Antagonists, Proton Pump Inhibitors
Pediatric Gastroesophageal Reflux Medication: Antacids, Histamine H2 Antagonists, Proton Pump Inhibitors (emedicine.medscape.com)
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Intermediate Uveitis Medication: Corticosteroids, Immunosuppressives, Histamine H2-receptor antagonist, Gastric pump inhibitors... (emedicine.medscape.com)
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APO 020 Pill Images (Pink / Red / Capsule-shape) (drugs.com)
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Prevacid price, Omeprazole and prevacid together (everythingandahappyending.com)
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Aturan Konsumsi Obat Omeprazole - Tanya Alodokter (alodokter.com)
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Omeprazole (Oral Route) Precautions - Mayo Clinic (mayoclinic.org)
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Accurate Pharmaceuticals Product Information | Medindia (medindia.net)
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List of drugs/medicine used for Vitamin B12 Deficiency (Vitamin B12 Deficiency) (medindia.net)
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606 PRILOSEC 10 Pill Images (Pink & Purple / Capsule-shape) (drugs.com)
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Logo 20 Pill Images (White / Capsule-shape) (drugs.com)
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Omeprazole, Amoxicillin, and Rifabutin | Memorial Sloan Kettering Cancer Center (mskcc.org)