Peptides composed of between two and twelve amino acids.
Peptides that inhibit mitosis (ANTIMITOTICS). During the 1960's the term referred to crude extracts that inhibited cell proliferation; the activity was later attributed to PYROGLUTAMATE type oligopeptides.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The simplest of all peptides. It functions as a gamma-glutamyl acceptor.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Peptides composed of two amino acid units.
A subclass of EXOPEPTIDASES that act on the free N terminus end of a polypeptide liberating a single amino acid residue. EC 3.4.11.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.
Antibodies that can catalyze a wide variety of chemical reactions. They are characterized by high substrate specificity and share many mechanistic features with enzymes.
A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.
The process of cleaving a chemical compound by the addition of a molecule of water.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
A non-pathogenic species of LACTOCOCCUS found in DAIRY PRODUCTS and responsible for the souring of MILK and the production of LACTIC ACID.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
The rate dynamics in chemical or physical systems.
A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
A subclass of exopeptidases that includes enzymes which cleave either two or three AMINO ACIDS from the end of a peptide chain.
A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Uptake of substances through the lining of the INTESTINES.
A mixture of related phosphoproteins occurring in milk and cheese. The group is characterized as one of the most nutritive milk proteins, containing all of the common amino acids and rich in the essential ones.
Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.
A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
An essential amino acid. It is often added to animal feed.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Sites on an antigen that interact with specific antibodies.
Proteins prepared by recombinant DNA technology.
Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.
Transport proteins that carry specific substances in the blood or across cell membranes.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
The sum of the weight of all the atoms in a molecule.
ENDOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Proteins found in any species of bacterium.
Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Established cell cultures that have the potential to propagate indefinitely.
Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
Proteins found in any species of virus.
Substances elaborated by viruses that have antigenic activity.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Antibodies produced by a single clone of cells.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors. (1/10855)

The terminal colon is aganglionic in mice lacking endothelin-3 or its receptor, endothelin B. To analyze the effects of endothelin-3/endothelin B on the differentiation of enteric neurons, E11-13 mouse gut was dissociated, and positive and negative immunoselection with antibodies to p75(NTR )were used to isolate neural crest- and non-crest-derived cells. mRNA encoding endothelin B was present in both the crest-and non-crest-derived cells, but that encoding preproendothelin-3 was detected only in the non-crest-derived population. The crest- and non-crest-derived cells were exposed in vitro to endothelin-3, IRL 1620 (an endothelin B agonist), and/or BQ 788 (an endothelin B antagonist). Neurons and glia developed only in cultures of crest-derived cells, and did so even when endothelin-3 was absent and BQ 788 was present. Endothelin-3 inhibited neuronal development, an effect that was mimicked by IRL 1620 and blocked by BQ 788. Endothelin-3 failed to stimulate the incorporation of [3H]thymidine or bromodeoxyuridine. Smooth muscle development in non-crest-derived cell cultures was promoted by endothelin-3 and inhibited by BQ 788. In contrast, transcription of laminin alpha1, a smooth muscle-derived promoter of neuronal development, was inhibited by endothelin-3, but promoted by BQ 788. Neurons did not develop in explants of the terminal bowel of E12 ls/ls (endothelin-3-deficient) mice, but could be induced to do so by endothelin-3 if a source of neural precursors was present. We suggest that endothelin-3/endothelin B normally prevents the premature differentiation of crest-derived precursors migrating to and within the fetal bowel, enabling the precursor population to persist long enough to finish colonizing the bowel.  (+info)

Primary haemostasis: sticky fingers cement the relationship. (2/10855)

Platelet aggregation to form a haemostatic plug, or thrombus, plays a key role in preventing bleeding from a wound. Recent studies have provided new insights into how platelet receptors are deployed during the interactions with the vascular subendothelial matrix that lead to haemostatic plug formation.  (+info)

Bcl-2 regulates amplification of caspase activation by cytochrome c. (3/10855)

Caspases, a family of specific proteases, have central roles in apoptosis [1]. Caspase activation in response to diverse apoptotic stimuli involves the relocalisation of cytochrome c from mitochondria to the cytoplasm where it stimulates the proteolytic processing of caspase precursors. Cytochrome c release is controlled by members of the Bcl-2 family of apoptosis regulators [2] [3]. The anti-apoptotic members Bcl-2 and Bcl-xL may also control caspase activation independently of cytochrome c relocalisation or may inhibit a positive feedback mechanism [4] [5] [6] [7]. Here, we investigate the role of Bcl-2 family proteins in the regulation of caspase activation using a model cell-free system. We found that Bcl-2 and Bcl-xL set a threshold in the amount of cytochrome c required to activate caspases, even in soluble extracts lacking mitochondria. Addition of dATP (which stimulates the procaspase-processing factor Apaf-1 [8] [9]) overcame inhibition of caspase activation by Bcl-2, but did not prevent the control of cytochrome c release from mitochondria by Bcl-2. Cytochrome c release was accelerated by active caspase-3 and this positive feedback was negatively regulated by Bcl-2. These results provide evidence for a mechanism to amplify caspase activation that is suppressed at several distinct steps by Bcl-2, even after cytochrome c is released from mitochondria.  (+info)

C/EBPalpha regulates generation of C/EBPbeta isoforms through activation of specific proteolytic cleavage. (4/10855)

C/EBPalpha and C/EBPbeta are intronless genes that can produce several N-terminally truncated isoforms through the process of alternative translation initiation at downstream AUG codons. C/EBPbeta has been reported to produce four isoforms: full-length 38-kDa C/EBPbeta, 35-kDa LAP (liver-enriched transcriptional activator protein), 21-kDa LIP (liver-enriched transcriptional inhibitory protein), and a 14-kDa isoform. In this report, we investigated the mechanisms by which C/EBPbeta isoforms are generated in the liver and in cultured cells. Using an in vitro translation system, we found that LIP can be generated by two mechanisms: alternative translation and a novel mechanism-specific proteolytic cleavage of full-length C/EBPbeta. Studies of mice in which the C/EBPalpha gene had been deleted (C/EBPalpha-/-) showed that the regulation of C/EBPbeta proteolysis is dependent on C/EBPalpha. The induction of C/EBPalpha in cultured cells leads to induced cleavage of C/EBPbeta to generate the LIP isoform. We characterized the cleavage activity in mouse liver extracts and found that the proteolytic cleavage activity is specific to prenatal and newborn livers, is sensitive to chymostatin, and is completely abolished in C/EBPalpha-/- animals. The lack of cleavage activity in the livers of C/EBPalpha-/- mice correlates with the decreased levels of LIP in the livers of these animals. Analysis of LIP production during liver regeneration showed that, in this system, the transient induction of LIP is dependent on the third AUG codon and most likely involves translational control. We propose that there are two mechanisms by which C/EBPbeta isoforms might be generated in the liver and in cultured cells: one that is determined by translation and a second that involves C/EBPalpha-dependent, specific proteolytic cleavage of full-length C/EBPbeta. The latter mechanism implicates C/EBPalpha in the regulation of posttranslational generation of the dominant negative C/EBPbeta isoform, LIP.  (+info)

Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity. (5/10855)

Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respective TCRs, showing that a single saccharide residue can be accommodated in the standard TCR-MHC geometry. The models also reveal a possible molecular basis for the observed cross-reactivity patterns of the CTL clones, which appear to be influenced by the length of the CDR3 loop and the nature of the immunizing ligand.  (+info)

Role of endothelin in the increased vascular tone of patients with essential hypertension. (6/10855)

We investigated the possible role of endothelin in the increased vasoconstrictor tone of hypertensive patients using antagonists of endothelin receptors. Forearm blood flow (FBF) responses (strain-gauge plethysmography) to intraarterial infusion of blockers of endothelin-A (ETA) (BQ-123) and endothelin-B (ETB) (BQ-788) receptors, separately and in combination, were measured in hypertensive patients and normotensive control subjects. In healthy subjects, BQ-123 alone or in combination with BQ-788 did not significantly modify FBF (P=0.78 and P=0.63, respectively). In hypertensive patients, in contrast, BQ-123 increased FBF by 33+/-7% (P<0.001 versus baseline), and the combination of BQ-123 and BQ-788 resulted in a greater vasodilator response (63+/-12%; P=0.006 versus BQ-123 alone in the same subjects). BQ-788 produced a divergent vasoactive effect in the two groups, with a decrease of FBF (17+/-5%; P=0.004 versus baseline) in control subjects and transient vasodilation (15+/-7% after 20 minutes) in hypertensive patients (P<0.001, hypertensives versus controls). The vasoconstrictor response to endothelin-1 was slightly higher (P=0.04) in hypertensive patients (46+/-4%) than in control subjects (32+/-4%). Our data indicate that patients with essential hypertension have increased vascular endothelin activity, which may be of pathophysiological relevance to their increased vascular tone. In these patients, nonselective ETA and ETB blockade seems to produce a greater vasodilator effect than selective ETA blockade.  (+info)

99mTc-labeled vasoactive intestinal peptide receptor agonist: functional studies. (7/10855)

Vasoactive intestinal peptide (VIP) is a naturally occurring 28-amino acid peptide with a wide range of biological activities. Recent reports suggest that VIP receptors are expressed on a variety of malignant tumor cells and that the receptor density is higher than for somatostatin. Our aims were to label VIP with 99mTc--a generator-produced, inexpensive radionuclide that possesses ideal characteristics for scintigraphic imaging--and to evaluate 99mTc-VIP for bioactivity and its ability to detect experimental tumors. METHODS: VIP28 was modified at the carboxy terminus by the addition of four amino acids that provided an N4 configuration for a strong chelation of 99mTc. To eliminate steric hindrance, 4-aminobutyric acid (Aba) was used as a spacer. VIP28 was labeled with 1251, which served as a control. Biological activity of the modified VIP28 agonist (TP3654) was examined in vitro using a cell-binding assay and an opossum internal anal sphincter (IAS) smooth muscle relaxivity assay. Tissue distribution studies were performed at 4 and 24 h after injection, and receptor-blocking assays were also performed in nude mice bearing human colorectal cancer LS174T. Blood clearance was examined in normal Sprague-Dawley rats. RESULTS: The yield of 99mTc-TP3654 was quantitative, and the yields of 125I-VIP and 1251-TP3654 were >90%. All in vitro data strongly suggested that the biological activity of 99mTc-TP3654 agonist was equivalent to that of VIP28. As the time after injection increased, radioactivity in all tissues decreased, except in the receptor-enriched tumor (P = 0.84) and in the lungs (P = 0.78). The tumor uptake (0.23 percentage injected dose per gram of tissue [%ID/g]) was several-fold higher than 125I-VIP (0.06 %ID/g) at 24 h after injection in the similar system. In mice treated with unlabeled VIP or TP3654, the uptake of 99mTc-TP3654 decreased in all VIP receptor-rich tissues except the kidneys. The blood clearance was biphasic; the alpha half-time was 5 min and the beta half-time was approximately 120 min. CONCLUSION: VIP28 was modified and successfully labeled with 99mTc. The results of all in vitro examinations indicated that the biological activity of TP3654 was equivalent to that of native VIP28 and tumor binding was receptor specific.  (+info)

Stimulation of phosphorylase kinase autophosphorylation by peptide analogs of phosphorylase. (8/10855)

Autoactivation of phosphorylase kinase in the presence of substrates has been studied to determine the cause of the hysteresis, or lag, in the phosphorylase kinase reaction. Peptide analogs corresponding to the convertible serine region of phosphorylase have been used as low molecular weight alternative substrates. Autophosphorylation of the kinase molecule was measured under conditions that favored autoactivation. Phosphorylase b and a tetradecapeptide, which was found to be a good model of phosphorylase, stimulated autoactivation by 86- and 37-fold, respectively. The tetradecapeptide also stimulated autophosphorylation of subunits A and B of the kinase molecule. This increased autophosphorylation coincided with an increased ability to convert phosphorylase. This finding supports the hypothesis that autophosphorylation is responsible for the lag in the phosphorylase kinase reaction. No evidence was obtained to suggest that the lag could be due to dissociation of the kinase. The stoichiometry of phosphate incorporation into phosphorylase kinase subunits by autophosphorylation was much greater than that reported to occur by protein kinase phosphorylation. Multiple phosphorylation sites in subunit A accounted for most of the phosphate incorporation during autophosphorylation. Saturating levels of hexa- and octapeptide analogs also caused stimulation of autophosphorylation. Possible mechanisms and experimental implications of substrate-stimulated autophosphorylation are discussed. Consideration also is given to the possible role of effectors in autophosphorylation in vivo.  (+info)

In vivo response to growth hormone-releasing peptide-6 in adrenocorticotropin-dependent Cushings syndrome by lung carcinoid tumor is associated with growth hor
Shop Trypsin-modulating oostatic factor ELISA Kit, Recombinant Protein and Trypsin-modulating oostatic factor Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Purpose: Stroke is the second cause of mortality worldwide, with a high incidence of disability in survivors. Promising candidate drugs have failed in stroke trials. Combined therapies are attractive strategies that simultaneously target different po
The RGD peptide is the binding motif of fibronectin to cell adhesion molecules. RGD peptide acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins. In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion. ...
Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.
Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane.
Sequences of human proteins are frequently prepared as synthetic oligopeptides to assess their functional ability to act as compounds modulating pathways involving the parent protein. Our objective was to analyze a set of oligopeptides, to determine if their solubility or activity correlated with features of their primary sequence, or with features of properties inferred from three-dimensional structural models derived by conformational searches. We generated a conformational database for a set of 78 oligopeptides, derived from human proteins, and correlated their 3D structures with solubility and biological assay activity (as measured by platelet activation and inhibition). Parameters of these conformers (frequency of coil, frequency of turns, the degree of packing, and the energy) did not correlate with solubility, which was instead partly predicted by two measures obtained from primary sequence analysis, that is, the hydrophobic moment and the number of charges. The platelet activity of ...
Sequences of human proteins are frequently prepared as synthetic oligopeptides to assess their functional ability to act as compounds modulating pathways involving the parent protein. Our objective was to analyze a set of oligopeptides, to determine if their solubility or activity correlated with features of their primary sequence, or with features of properties inferred from three-dimensional structural models derived by conformational searches. We generated a conformational database for a set of 78 oligopeptides, derived from human proteins, and correlated their 3D structures with solubility and biological assay activity (as measured by platelet activation and inhibition). Parameters of these conformers (frequency of coil, frequency of turns, the degree of packing, and the energy) did not correlate with solubility, which was instead partly predicted by two measures obtained from primary sequence analysis, that is, the hydrophobic moment and the number of charges. The platelet activity of ...
Results: 178 patients (pts) were observed for 1-81 (median 16.5, IQR 7-27) months totaling 325 patient years. Mean age at switch was 44 years, mean weight 76 kg, mean CD4 516 cells/mm3. Duration of preceding viral suppression was 0 - 177 (median 18, IQR 7-38) months. Most common preceding regimen was ATV/r+TDF+FTC (89 pts). Most common reasons given for switching to ATV+TDF+FTC were simplification (83 pts), dyslipidemia (17), gastrointestinal toxicity (10), coronary risk (10), CNS toxicity (10), hyperbilirubinemia (6 ...
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An FDA snapshot analysis determined sub-50-copy 48-week response rates of 90% with Quad and 87% with atazanavir, a result establishing the virologic noninferiority of Quad in previously untreated people. A missing-data-equals-failure analysis determined sub-50-copy rates of 92% with Quad and 88% with atazanavir. Among people with a pretreatment viral load above 100,000 copies, 50-copy response rates were 85% with Quad and 82% with atazanavir; respective response rates in those starting treatment with at CD4 count at or below 350 were 89% and 88%. CD4 counts rose by an average 207 with Quad and 211 with atazanavir ...
-Viral cure rates of 92 and 88 with 24 and 48-week regimens, respectively, in people who met certain response criteria- -Safety and tolerability results were si
JPT Peptide Technologies is a DIN ISO 9001:2015 certified and GCLP compliant integrated provider of innovative peptide based catalog products and custom services.
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Description of the drug Atazanavir Sulfate. - patient information, description, dosage and directions. What is Atazanavir Sulfate!
Buy Atazanavir Online! Atazanavir is also sometimes used to prevent infection in healthcare workers or other people who were accidentally exposed to HIV. Talk to your doctor about the risks of using this medication for your condition. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Buy Atazanavir Online! Atazanavir is also sometimes used to prevent infection in healthcare workers or other people who were accidentally exposed to HIV. Talk to your doctor about the risks of using this medication for your condition. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
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Účinky Hexarelin-u: Hexarelin najúčinnejšie stimuluje sekréciu rastového hormónu spomedzi všetkých GHRP (GHR peptidov) Hexarelin významne
Learn what medical issues to discuss with the doctor before taking REYATAZ® (atazanavir) as part of an HIV-1 treatment regimen. Read risk information and full Prescribing Information.
Get answers to frequently asked questions about HIV and about EVOTAZ® (atazanavir/cobicistat). Read risk info and full Prescribing Information.
Can you name the facts about the Fahrenheit temperature scale? Test your knowledge on this science quiz to see how you do and compare your score to others. Quiz by Anne13
TY - JOUR. T1 - Inhibition of angiogenesis in vitro and in vivo. T2 - Comparison of the relative activities of triflavin, an Arg-Gly-Asp-containing peptide and anti-α(v)β3 integrin monoclonal antibody. AU - Sheu, Joen Rong. AU - Yen, Mao Hsiung. AU - Kan, Ya Chen. AU - Hung, Wei Chun. AU - Chang, Pei Te. AU - Luk, Hsiang Ning. PY - 1997/10/20. Y1 - 1997/10/20. N2 - Disintegrin which contains the amino acid sequence Arg-Gly-Asp (RGD), has been implicated as a recognition site in interactions between extracellular matrix (ECM) and cell membrane receptors. Triflavin, a 7.5 kDa cysteine-rich polypeptide purified from Trimeresurus flavoviridis snake venom, belongs to a family of disintegrins. Integrin α(v)β3 has recently been identified as a marker of angiogenic blood vessels and therefore anti-α(v)β3 mAb may significantly inhibit angiogenesis. Therefore, this study was designed to compare the relative activity of triflavin and anti-α(v)β3 mAb in human umbilical vein endothelial cell (HUVEC) ...
The results of the IMPAACT/PACTG 1020A trial in children and adolescents indicate that, in the absence of ritonavir boosting, atazanavir can achieve protocol-defined PK targets-but only when used at higher doses of atazanavir (on a mg/kg body weight or mg/m2 body surface area basis) than doses currently recommended in adults. In IMPAACT/PACTG 1020A, children aged ,6 to ,13 years required atazanavir dosing of 520 mg/m2 per day of atazanavir capsule formulation to achieve PK targets.8 Unboosted atazanavir at this dose was well tolerated in those aged ,13 years who were able to swallow capsules.11 Doses required for older adolescents were greater than the adult approved dose of 400 mg atazanavir given without ritonavir boosting once daily; adolescents aged ,13 years required atazanavir dosing of 620 mg/m2 per day.8 In this study, the AUCs for the unboosted arms were similar to the ATV/r groups but the maximum plasma concentration (Cmax) was higher and minimum plasma concentration (Cmin) lower for ...
This study was aimed to determine the anticancer efficacy of the combination of paclitaxel, the standard treatment of breast cancer, and carfilzomib, ..
Role of RGD-binding integrins in uPAR-induced protrusions and adhesion. (A) Swiss 3T3 cells were injected with pRc/CMV-uPAR (100 μg/ml) and incubated in growth
3762 In its normal life cycle, B. pertussis attaches to, and invades ciliated epithelia and macrophages of the human airways, using adhesins specialized for certain oligosaccharides and proteins on these cells. Here we report that B. pertussis uses similar mechanisms for invasion of a variety of human cancer cells in vitro, and exhibits potent, invasion-dependent, cytotoxicity. In a 30′ in vitro invasion assay, B. pertussis invaded human SKmel-23 melanoma cells at 20-30 times the rate for normal human melanocytes and fibroblasts. B. pertussis invasion of SKmel-23 cells was inhibited by preincubation of cancer cells with glycosidase F, the plant lectins LPHA and TGP, human antibodies vs CD15 and CD11b, or the RGD tripeptide sequence-implying that the structural requirements for invasion included β1,6-branched N-glycans, Lewis × antigens, CD11b, and the sequence arg-gly-asp respectivelly. Invasion was also inhibited by preincubation of cancer cells with 3-methyladenine (3-MA), indicating a ...
預計在今年(2011)暑假通過 FDA 核准的 C 型肝炎強效新藥,Merck 藥廠的 boceprevir 與 Vertex Pharmaceuticals Inc. 藥廠的 telaprevir,FDA諮詢委員會(advisory committee)在四月27日與28日分別舉行會議,對藥物的安全性進行評估。. Telaprevir 與 Boceprevir 皆為針對第一基因型慢性 C 型肝炎的藥物,適用於未曾接受過治療、或對先前治療無效、但肝臟仍舊具有執行功能的患者(compensated stage)。. 與目前 C 型肝炎的臨床治療藥物相較之下,Telaprevir與Boceprevir有更強的治療效果,不過,卻也有較嚴重的副作用。現行的 C 肝藥物多半只會引起類似流感的副作用,而 Boceprevir 的潛在副作用則包括貧血、以及多個出現精神疾患的案例,精神疾患包括有自殺或殺人的傾向。. 由於使用 Boceprevir 治療 C 型肝炎的處方中,必須同時搭配使用長效型干擾素(peginterferon ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
A treatment regimen containing the experimental hepatitis C virus (HCV) antiviral telaprevir can cure HCV after 24 weeks of treatment, without requiring a full 48-week course of therapy, in people with HCV genotype 1 who have undetectable virus levels after 4 and 12 weeks of therapy. These early results from a clinical trial conducted by Vertex Pharmaceuticals were reported in a press release from the company.
Endomorphin (EM)-1 and EM-2 are tetrapeptides located within the mammalian central nervous system and immune tissues, with high affinity and specificity for μ-opioid receptors. Most of the literature...
In this study we focused on the signaling of V antigen-induced innate immunity responses. For the first time we demonstrate that a bacterial nonlipidated protein associated with virulence and derived synthetic oligopeptides are capable to induce IL-10 production via TLR2/CD14 signaling. In contrast to the pseudomonas rPcrV, rLcrV (range of activity: 10-100 nM) transmits signaling via TLR2 in a CD14-dependent manner leading to IL-10 induction which finally causes TNF-α suppression thus probably enabling yersiniae to evade the host innate immune system. Several lines of evidence obtained in vitro both in murine and human cell systems support this conclusion: (a) Only CD14-TLR2-cotransfected HEK 293 cells, but not cells transfected with TLR2 alone responded with NF-κB-dependent ELAM-1 promoter luciferase activity upon rLcrV stimulation. (b) Blocking anti-CD14 monoclonal antibodies, but not nonblocking isotype anti-CD14 antibodies completely abolished TNF-α suppression in LcrV-treated MonoMac-6 ...
As we aim towards enhancing our knowledge of complex cell behaviors and developing intricate cell-based devices and improved therapeutics, it becomes imperative that we be able to control and manipula
Atazanavir - Get up-to-date information on Atazanavir side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Atazanavir
InCELLect™ St-Ht31P Control Peptide is a stearated form of the peptide Ht-31P. This peptide has been used as a negative control peptide for the study of InCELLect™ AKAP St-Ht31 Inhibitor Peptide.
CLINICAL TRIAL ASSESSING ONCE DAILY RALTEGRAVIR ADMINISTRATION (800 mg QD) IN HIV-1-INFECTED PATIENTS RECEIVING UNBOOSTED ATAZANAVIR (400 mg QD)-BASED ANTIRETROVIRAL THERAPY (ENSAYO CLÍNICO PARA EVALUAR LA ADMINISTRACIÓN DE RALTEGRAVIR UNA VEZ AL DÍA (800 mg QD) EN PACIENTES INFECTADOS POR EL VIH-1 QUE RECIBEN TERAPIA ANTIRETROVIRAL BASADA EN ATAZANAVIR NO POTENCIADO (400 mg QD ...
Second, Table 3 in the article, outlining the toxicity associated with the regimens, is a gem. This is how we would like adverse events reported. From this table, it is apparent that it is important to keep in mind the small but definite risk of hypertension, dyspnea, and cardiac failure associated with carfilzomib. On the other hand, the risk of neuropathy is definitely lower with this drug compared with bortezomib. Finally, a comparison of overall survival results from other randomized trials in the relapsed setting (outlined well in the discussion section of the article) shows it is extremely difficult to achieve this magnitude of survival benefit, even with trials that lacked an active control equivalent. This reveals the value of carfilzomib as an added option for the treatment of myeloma. Take-Home Points HOW DO THE ENDEAVOR RESULTS change our current practice? With a definitive improvement in overall survival, ENDEAVOR ensconces the safety and efficacy of carfilzomib and provides evidence ...
Healthy 99% Human-Peptide 87616-84-0 Polypeptide Hormones GHRP-6 GHRP-6,releasing peptide-6 (GHRP-6) is in the category of drugs known as GH Secretagogues. This category of drugs includes GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. Their primary...
Telaprevir - Get up-to-date information on Telaprevir side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Telaprevir
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Chosen biweekly by Rachel Grabenhofer, editor of Cosmetics Toiletries magazine, for their relevance to personal care, Patent Picks are taken from publicly available sources. This edition features recently issued patents related to sensates, feel enhancers and other physical/visual cues in personal care.
Chosen biweekly by Rachel Grabenhofer, editor of Cosmetics Toiletries magazine, for their relevance to personal care, Patent Picks are taken from publicly available sources. This edition features recently issued patents related to sensates, feel enhancers and other physical/visual cues in personal care.
Donne DG, Viles JH, Groth D, Mehlhorn I, James TL, Cohen FE, Prusiner SB, Wright PE, Dyson HJ. Multiple solution conformations of the integrin-binding cyclic pentapeptide cyclo(-Ser-D-Leu-Asp-Val-Pro-). Analysis of the (phi, psi) space available to cyclic pentapeptides ...
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Gonzalez, P., Peluffo, H., Acarin, L., Villaverde, A., Gonzalez, B. and Castellano, B. (2012), Interleukin-10 overexpression does not synergize with the neuroprotective action of RGD-containing vectors after postnatal brain excitotoxicity but modulates the main inflammatory cell responses. J. Neurosci. Res., 90: 143-159. doi: 10.1002/jnr.22741 ...
ATAZANAVIR (at a za NA veer) is an antiretroviral medicine. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. It will not stop the spread of HIV to others.
3VB5: Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases
Buy Hexarelin 2mg at Peptides for Sale USA. Huge selection of Peptides, Research Chemicals, SARMs, solvents, lab supplies & more!
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
Regulatpro® Bio je kaskadno fermentiran bio koncentrat, proizveden iz ekološkega sadja, zelenjave, oreščkov in začimb. Edinstven encimski napitek vsebuje vitalne dipeptide, tripeptide, oligopeptide, polifenole, flavonoide (fitokemikalije) in desnosučno mlečno kislino L(+). V patentiranem procesu kaskadne fermentacije se aktivne substance iz prvovrstnih naravnih virov razdrobijo v drobne delce, ki zagotavljajo visoko absorpcijo v obliki koncentriranega napitka Regulatpro® Bio.. ...
After reconsituting my last two batches of GHRP2, and letting them sit in the fridge for a while before initial injection, both times there were
Looking for online definition of alkaline blood serum in the Medical Dictionary? alkaline blood serum explanation free. What is alkaline blood serum? Meaning of alkaline blood serum medical term. What does alkaline blood serum mean?
This page was last modified 11:06, 29 October 2010 by Neil Hauge. Based on work by , Nitin Dahyabhai and David Williams and others.. ...
An oligopeptide, often just called peptide (oligo-, "a few"), consists of two to twenty amino acids and can include dipeptides ... Netropsin - A basic oligopeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T ... Antipain - An oligopeptide produced by various bacteria which acts as a protease inhibitor. Ceruletide - A specific decapeptide ... Pepstatins - N-acylated oligopeptides isolated from culture filtrates of Actinomycetes, which act specifically to inhibit acid ...
... is the part of renal physiology that deals with the retrieval of filtered oligopeptides, ... Longer oligopeptides, such as angiotensin and glutathione are degraded by enzymes on the brush border, while shorter ones, such ...
... is a synthetic, pH controlled self-assembling peptide used for biomimetic mineralization e.g. for enamel ... P11-4 (INCI name Oligopeptide 104) consists of the natural occurring amino acids Glutamine, Glutamic acid, Phenylalanine, ... "European Commission database with information on cosmetic substances and ingredients". Oligopeptide 104. Retrieved 1 July 2015 ... Medicine portal Amorphous calcium phosphate Remineralisation of teeth Oligopeptide Biomimetic materials Fluoride Recaldent ...
... oligopeptide(in) The 3 substrates of this enzyme are ATP, H2O, and oligopeptide, whereas its 3 products are ADP, phosphate, and ... In enzymology, an oligopeptide-transporting ATPase (EC 3.6.3.23) is an enzyme that catalyzes the chemical reaction ATP + H2O + ... The systematic name of this enzyme class is ATP phosphohydrolase (oligopeptide-importing). This enzyme is also called ... of the oligopeptide permease of Salmonella typhimurium". Mol. Microbiol. 6 (1): 47-57. doi:10.1111/j.1365-2958.1992.tb00836.x. ...
The proton-dependent oligopeptide transporter (PTR) family of proteins is distinct from the ABC-type peptide transporters and ... As of this edit, this article uses content from "2.A.17 The Proton-dependent Oligopeptide Transporter (POT/PTR) Family", which ... Oligopeptide transporter, peptide:H+ symporter InterPro: IPR004768 Amino acid/peptide transporter InterPro: IPR005279 FP12591; ... Proteins of the Proton-dependent Oligopeptide Transporter (POT) Family (also called the PTR (peptide transport) family) are ...
Molecular dynamics of oligopeptides. 3. Maps of levels of free energy of modified dipeptides and dynamic correlation in amino ...
The cinchona alkaloids, certain oligopeptides. Synthetic catalysts derived from biomolecules. Hydrogen bonding catalysts, ...
... various N-formyl oligopeptides that, like FMLP, are either released by microbes and mitochondria or are analogs of those ... released by microbes and mitochondria; b) microbe-derived non-formyl oligopeptides; c) certain polypeptides that are associated ...
... oligopeptides such as N-Formylmethionine-leucyl-phenylalanine; and various proteins such as the amino acid 1 to 42 fragment of ...
Oligopeptide Fyles, Thomas Murray; Luong, Horace (2009). "Solid-phase synthesis of a library of linear oligoester ion-channels ...
PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton ... Gonzalez DE, Covitz KM, Sadée W, Mrsny RJ (1998). "An oligopeptide transporter is expressed at high levels in the pancreatic ... Adibi SA (2003). "Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease". Am. J. ... "Entrez Gene: SLC15A1 Solute carrier family 15 (oligopeptide transporter), member 1". Liang R, Fei YJ, Prasad PD, Ramamoorthy S ...
Array-based oligo-peptide scanning. Also known as overlapping peptide scan or pepscan analysis, this technique uses a library ... For example, an antibody against CD20 was mapped in a study using array-based oligo-peptide scanning, by combining non-adjacent ... of oligo-peptide sequences from overlapping and non-overlapping segments of a target protein, and tests for their ability to ...
... alpha-oligopeptides". The FEBS Journal. 273 (23): 5261-72. doi:10.1111/j.1742-4658.2006.05519.x. PMID 17064315. S2CID 84167461 ... beta-oligopeptides". Chemistry & Biodiversity. 3 (12): 1325-48. doi:10.1002/cbdv.200690136. PMID 17193247. S2CID 38292191. ... "Bacterial beta-peptidyl aminopeptidases with unique substrate specificities for beta-oligopeptides and mixed beta, ...
"NMR Signal Enhancement by Effective SABRE Labeling of Oligopeptides". Chemistry - A European Journal. 21 (36): 12616-12619. doi ... "Magnetic Resonance Signal Amplification by Reversible Exchange of Selective PyFALGEA Oligopeptide Ligands Towards Epidermal ...
One example is oligopeptide P11-4. In dental orthopedics and implants, a more traditional strategy to improve the density of ...
Of particular interest are cyclic oligopeptides with 8 aminoacid rings. The leaves are known to contain the flavonoids ...
The 3 most popular ways of visualizing the alpha-helical secondary structure of oligopeptide sequences are (1) a helical wheel ... Changes in binding orientation also occur for facially-organized oligopeptides. This pattern is especially common in ... oligopeptides readily adopt stable α-helical structure. Furthermore, crosslinks can be incorporated into peptides to ...
CSF is a five amino acid oligopeptide and is exported via the GSP pathway. CSF enters the cell through oligopeptide permeate ... ComX is a ten amino acid oligopeptide; it requires two co-components, ComP, an histidine kinase, and ComA, a cytoplasmic ...
Cooperman BS (2003). "Oligopeptide inhibition of class I ribonucleotide reductases". Biopolymers. 71 (2): 117-31. doi:10.1002/ ...
Tandem repeats of short oligopeptides that are rich in glycine, proline, serine or threonine are capable of forming flexible ... Thus, these two codons and their respective amino acids must have been constituents of the earliest oligopeptides, with a ... Trifonov, Edward N. (September 2009). "The origin of the genetic code and of the earliest oligopeptides". Research in ... the early genetic code may have also produced low complexity oligo-peptides from valine and leucine. However, later on, within ...
Trifonov, Edward N. (September 2009). "The origin of the genetic code and of the earliest oligopeptides". Research in ...
The trypsin found in pancreatin works to hydrolyze proteins into oligopeptides; amylase hydrolyzes starches into ...
Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to ...
An oligopeptide, angiotensin is a hormone and a dipsogen. It is derived from the precursor molecule angiotensinogen, a serum ...
1995). "Self-complementary oligopeptide matrices support mammalian cell attachment". Biomaterials. 16 (18): 1385-1393. doi: ... 1993). "Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane" (PDF). Proc. Natl. ...
Blanco, Celia; Hochberg, David (2012). "Homochiral oligopeptides by chiral amplification: interpretation of experimental data ...
Many oligopeptides that possess an N-Formylmethionine N-terminal residue such as the prototypical tripeptide N-Formylmethionine ... Early studies suggested that these formyl oligopeptides operated by a Receptor (biochemistry) mechanism. Accordingly, the human ... function by binding any one of a wide variety of ligands including not only certain N-Formylmethionine-containing oligopeptides ... a gene that when transfected into FMLP-unresponsive cells bestowed responsiveness to this and other N-formyl oligopeptides. ...
This enzyme catalyses the following chemical reaction Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly ...
Unlike some AHLs, however, most oligopeptides do not act as transcription factors themselves. The free-living bioluminescent ... Gram-positive bacteria that participate in quorum sensing typically use secreted oligopeptides as autoinducers. Peptide ... Whereas Gram-negative bacteria primarily use acylated homoserine lactones, Gram-positive bacteria generally use oligopeptides ...
Instead, fMet-containing oligopeptides and proteins appear to be released by the mitochondria of damaged tissues as well as by ... fMet-containing oligopeptides and proteins also function in other physiological and pathological responses. Formyl peptide ... The prototypical fMet-containing oligopeptide is N-formylmethionine-leucyl-phenylalanine (FMLP) which activates leukocytes and ... the fMet-containing oligopeptides and proteins are part of the innate immune system; they function to initiate acute ...
FDA and University of Maryland CERSI Lecture on the Role and Relevance of Proton-Coupled Oligopeptide Transporters in the Brain ... to his newest research on the role and relevance of proton-coupled oligopeptide transporters (PepT2 and PhT1) in this sanctuary ... physiology and pharmacology of proton-coupled oligopeptide transporters. ...
B.-r. Zhou, L.-w. Ma, J. Liu et al., "Protective Effects of Soy OligoPeptides in Ultraviolet B-Induced Acute Photodamage of ... Oxidative Medicine and Cellular Longevity has retracted the article titled "Protective Effects of Soy Oligopeptides in ... Retracted: Protective Effects of Soy Oligopeptides in Ultraviolet B-Induced Acute Photodamage of Human Skin. Oxidative Medicine ...
In this work, helical oligopeptides mimicking the VEGF-C helix were rationally designed based on structural analyses and ... In this work, helical oligopeptides mimicking the VEGF-C helix were rationally designed based on structural analyses and ... For this reason, such Cα,α-disubstituted amino acids constitute suitable building blocks to synthesize oligopeptide with a ... In this work, helical oligopeptides mimicking the VEGF-C helix were rationally designed based on structural analyses and ...
... Molecular Recognition between Oligopeptides and Nucleic Acids : Sequence-Specific Binding of the Naturally Occurring Antibiotic ... Molecular Recognition between Oligopeptides and Nucleic Acids : Sequence-Specific Binding of the Naturally Occurring Antibiotic ...
Ginseng oligopeptides could be a novel natural agent for relieving exercise fatigue. ... Ginseng oligopeptides could be a novel natural agent for relieving exercise fatigue. - GreenMedInfo Summary ... There were more studies on ginsenosides and polysaccharides, but fewer studies on ginseng oligopeptides (GOP), which are small ... Anti-Fatigue Effects of Small Molecule Oligopeptides Isolated from Panax ginseng C. A. Meyer in Mice. ...
Variable domain sequences of mAb with high affinity for a linear oligopeptide ... Variable domain sequences of mAb with high affinity for a linear oligopeptide ...
MINIRES is an oligopeptide based on a recurring consensus sequence in resilin, a particular natural elastomeric protein, ... The presence of halogenated atoms does not affect the toxicity of the patented oligopeptides, even at high concentrations but ... The halogenation of at least one oligopeptide residue allows to replicate the elastic properties of the entire resilin, ... The halogenation of at least one oligopeptide residue allows to replicate the elastic properties of the entire resilin, ...
The nonribosomal oligopeptide profile adds another potential identification criterion in future inter- and intraspecies ... Chemical analyses of the strain indicated production of nonribosomal oligopeptides. In fractionated extracts, masses and ion ... The strain was characterized by morphological features, partial 16S rRNA sequence and nonribosomal oligopeptide profile. The ... Nonribosomal Oligopeptides Produced by Strain 06S067. In this study, the production of APs was indicated in an established ...
WATER, OLIGOPEPTIDE-5, BUTYLENE GLYCOL, SODIUM POLYACRYLATE, SODIUM HYALURONATE, FIBRONECTIN, SNOW FUNGUS EXTRACT, CENTELLA ...
... rh-oligopeptide 1) for the use of skincare and biopharma industry. ... hEGF, or oligopeptide-1 was the first Growth Factor that made its way into cosmetic products and Stanley Cohen was awarded a ...
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Prediction of Efficacy of Oligo-Peptides using QSAR and ANN. Author(s): Rana D, Sangave P and Bhagwat S Artificial Neural ...
Serum metabolic effects of corn oligopeptides with 7-day supplementation on early post-surgery primary liver cancer patients: a ...
Business Development Manager, Oligo/Peptide Discovery Full time @WuXi AppTec STA posted 1 month ago in Life Sciences * United ... This position will report to the Director of Business Development, Oligo/Peptide and will help to support Discovery O&P BD ...
Thermoresponsive micelles from oligopeptide-grafted cyclotriphosphazenes. Yong Joo Jun, Udaya S. Toti, Hye Young Kim, Ji Young ... Dive into the research topics of Thermoresponsive micelles from oligopeptide-grafted cyclotriphosphazenes. Together they form ...
Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT) ... Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT) ...
Αρχική σελίδα / Brands / Yellow Rose / Yellow Rose Hyaluronic Beauty Elixir with oligopeptides and flower extracts - 30ml. ... Αρχική σελίδα / Brands / Yellow Rose / Yellow Rose Hyaluronic Beauty Elixir with oligopeptides and flower extracts - 30ml. ... Yellow Rose Hyaluronic Beauty Elixir with oligopeptides and flower extracts - 30ml ποσότητα. ... Yellow Rose Hyaluronic Face Firming Cream with oligopeptides and flower extracts - 50ml. ...
Oligopeptides / pharmacology* * Peptide Fragments / antagonists & inhibitors* * Peptide Fragments / metabolism * Protein ...
Jha S, Gupta SK, Bhattacharyya P, Ghosh A, Mandal P. In vitro Antioxidant and Antidiabetic Activity of Oligopeptides Derived ... Keywords:Antidiabetic, Antioxidant, High‑performance liquid chromatography, Mulberry, Oligopeptide, Ultrafiltration. View:. * ... Home / Pharmacognosy Research, Vol 10, Issue 4, Oct-Dec, 2018 / In vitro Antioxidant and Antidiabetic Activity of Oligopeptides ... Further, the variation in amino acid composition of the oligopeptides could be associated with the observed variation in their ...
Specific Ion Effects on an Oligopeptide: Bidentate binding matters for the Guanidinium Cation ... Specific Ion Effects on an Oligopeptide: Bidentate binding matters for the Guanidinium Cation Balos, V., Marekha, B. A., Malm, ... 2019). Specific Ion Effects on an Oligopeptide: Bidentate binding matters for the Guanidinium Cation. Angewandte Chemie ...
... rh-Oligopeptide-1, Tocopheryl Acetate, Thioctic Acid, Simmondsia Chinensis (Jojoba) Seed Oil, Acetyl Hexapeptide-8, Superoxide ... Dismutase, Palmitoyl Tetrapeptide-7, Palmitoyl Oligopeptide, Phyllanthus Emblica Fruit Extract, Niacinamide, Carnosine, Citrus ...
Protein residues (oligo-peptides) travel to the intestine in the portal vein *Recognition of oligo-peptides by μ-opioid ... These receptors are inhibited by oligo-peptides, produced during protein digestion.. In an initial phase, the oglio-peptides ...
Self-assembly of phenylalanine oligopeptides: insights from experiments and simulations. Biophys. J. 96, 5020-5029 (2009). ... Zhang, S., Holmes, T., Lockshin, C. & Rich, A. Spontaneous assembly of a self-complementary oligopeptide to form a stable ...
Salt Bridge Swapping in the EXXERFXYY Motif of Proton-coupled Oligopeptide Transporters. Journal of Biological Chemistry ... Background: Proton-coupled oligopeptide transporters (POTs) facilitate di- and tripeptide uptake.Results: Both glutamates of ...
Carrier-mediated transport of oligopeptides in the human fibrosarcoma cell line HT1080.. *T. Nakanishi, I. Tamai, Y. Sai, T. ... Antitumor activity of the alkylating oligopeptides J1 (L-melphalanyl-p-L-fluorophenylalanine ethyl ester) and P2 (L-prolyl-m-L- ... Peptichemio (PTC), a mixture of six oligopeptides all containing m-L-sarcolysin, has previously shown impressive results in ... which is similar but not identical to the well-characterized oligopeptide transporters PepT1 and PepT2, exists in fibroblast- ...
Oligopeptide transporters (OPTs) encode integral membrane-localized pr... ... rapa) oligopeptide transporters gene family Yanan Pua,b,c,d, Danni Yanga,b,c,d, Xin Yina,b,c,d, Qiuli Wanga,b,c,e, Qian Chena,b ... Analyses of the oligopeptide transporter gene family in poplar and grape. BMC Genomics 12, 465.. Cheng, F., Sun, R., Hou, X., ... Evolution of the oligopeptide transporter family. J. Membr. Biol. 240, 89-110.. Gruber, B.D., Giehl, R.F., Friedel, S., von ...
Characterization and evaluation of the Moraxella catarrhalis oligopeptide permease A as a mucosal vaccine antigen. Infect Immun ...
  • Mulberry Extract, Green Tea Extract, and Oligopeptide-51 - an advanced ingredient blend that decreases the production of unwanted pigment to brighten skin and produce a clear, even complexion. (dermapro.com)
  • Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT) family. (ox.ac.uk)
  • Analyses of the oligopeptide transporter gene family in poplar and grape. (kib.ac.cn)
  • The oligopeptide transporter (PepT 1), which is located in the intestinal brush border membrane, provides a major mechanism for protein absorption in the small intestine. (tokushima-u.ac.jp)
  • PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. (cdc.gov)
  • During his career, he has made many important scientific contributions, including those on the kinetic-dynamic relationship of loop diuretics, the determinants of renal drug elimination, the regional pharmacokinetics of anticancer drugs, and the cellular and molecular biology, physiology and pharmacology of proton-coupled oligopeptide transporters. (fda.gov)
  • In this presentation, Dr. Smith gave a general overview of drug transporters in the brain and, more specifically, to his newest research on the role and relevance of proton-coupled oligopeptide transporters (PepT2 and PhT1) in this sanctuary tissue. (fda.gov)
  • The proton coupled oligopeptide transporters, PepT1 and PepT2, have been successfully targeted using this approach. (biorxiv.org)
  • The halogenation of at least one oligopeptide residue allows to replicate the elastic properties of the entire resilin, enhancing the spontaneous self-assembly of the peptide, without the need to chemical cross-linking. (knowledge-share.eu)
  • Hydrolyze contains Palmitoyl peptides (Oligopeptide and Tripeptide 7) , to improve the skin's elasticity. (prweb.com)
  • Oligopeptide transporters (OPTs) encode integral membrane-localized proteins and have a broad range of substrate transport capabilities.Here,28 BrrOPT genes were identified in the turnip.Phylogenetic analyses revealed two well-supported clades in the OPT family,containing 15 BrrOPTs and 13 BrrYSLs. (kib.ac.cn)
  • rapa ) oligopeptide transporters gene family[J]. Plant Diversity, 2018, 40(02): 57-67. (kib.ac.cn)
  • MINIRES is an oligopeptide based on a recurring consensus sequence in resilin, a particular natural elastomeric protein, constituting the elastic structures in insects. (knowledge-share.eu)
  • The 0.5-3 kDa ranged oligopeptides were isolated using cation exchange chromatography and ultrafiltration system and further characterized by high‑performance liquid chromatography and protein sequencer. (phcogres.com)
  • Det unike serumet benytter en plantebasert kopi av EGF (et naturlig forekommende humant protein) og reduserer effektivt synligheten av fine linjer, rynker og porer samtidig som det gir økt glød. (lookfantastic.com)
  • Gjenoppdag hudens ungdommelige glød med BIOEFFECT EGF Serum , en banebrytende behandling som motvirker aldringstegn og gir synlige og betydelige resultater. (lookfantastic.com)
  • Numerous disulfide bonds determine a specific oligopeptide or polypeptide conformation for each toxin to better fit the target. (medscape.com)
  • Collagen oligopeptides (ligands) attach to fibroblasts (bone formation cells) receptors on the fibroblast membrane synthesizing new collagen production (1,2,3). (eatyournutrition.com)
  • Self-assembly of phenylalanine oligopeptides: insights from experiments and simulations. (nature.com)
  • A polypeptide composed of L-lysine and L-arginine oligopeptides. (zelens.com)
  • Terminal digestion of oligopeptides and disaccharides before absorption is performed by brush border enzymes, either at the surface of the enterocyte in association with transport proteins for their specific products or when released into the intestinal lumen through cleavage by pancreatic peptidases or enzymes freed from exfoliated senescent enterocytes. (msdvetmanual.com)
  • Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity. (mpg.de)
  • The synthetic modified oligopeptides, available in quantity, served both as immunogens and as chemical standards for quantitative ELISA. (cdc.gov)
  • Oxidative Medicine and Cellular Longevity has retracted the article titled "Protective Effects of Soy Oligopeptides in Ultraviolet B-Induced Acute Photodamage of Human Skin" [ 1 ]. (hindawi.com)
  • Protective Effects of Soy OligoPeptides in Ultraviolet B-Induced Acute Photodamage of Human Skin," Oxidative Medicine and Cellular Longevity , vol. 2016, Article ID 5846865, 13 pages, 2016. (hindawi.com)
  • Anti-Fatigue Effects of Small Molecule Oligopeptides Isolated from Panax ginseng C. A. Meyer in Mice. (greenmedinfo.com)
  • Oligopeptide-1 has well-established wound healing and skin renewal properties. (bioboostsynbio.com)
  • Endothelins are a family of 21-amino acid oligopeptides, called endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin 3 (ET-3). (istun.edu.tr)
  • There were more studies on ginsenosides and polysaccharides, but fewer studies on ginseng oligopeptides (GOP), which are small molecule oligopeptides isolated from ginseng. (greenmedinfo.com)
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  • De Grown Alchemist Regenerating Night Cream Neuro-Peptide & Violet Leaf Extract is een voedende, hydraterende collageencrème die de strijd tegen rimpels, ouderdomsvlekjes en een verouderde huid aangaat terwijl jij ligt te slapen. (boozyshop.nl)
  • Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide-7 work in synergy to help restore and maintain your skin's youthful appearance. (marykay.com)
  • Triple Peptide Complex: Palmitoyl oligopeptides, argireline, and vitamin C polypeptides smooth the look of skin, reducing the appearance of deep lines and dark circles. (sephora.com)
  • In this formula, it aids the skin in benefitting from the water-binding effects of hyaluronic acid and the smoothing and anti-aging effects of palmitoyl oligopeptide. (imageskincare.com)
  • Oligopeptide-1 has an identical chemical structure to an epidermal growth factor and has been shown to increase the rate of healing and renewal of the skin, as well as slow the thinning of aging skin, thus minimizing wrinkles. (arielbiotech.com)
  • A new family of β-lactam transporting proton coupled oligopeptide transporters has been cloned from mammalian epithelial cells of kidney, 8- 10 brain, 11 and intestine 12- 15 in the past years. (bmj.com)
  • Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. (drugbank.com)
  • Featuring super ingredients Oligopeptide-1, Oligopeptide-5, and Oligopeptide-10, the marine revival essence is the epitome of regenerating power. (haach.com)
  • I just cannot recommend a $110 serum that only features HA, proprietary EGF, oligopeptide-1, and two Saccharomyces based ingredients. (skinsciencebymira.com)
  • Immune response to oligopeptide permease A (OppA) protein in pigs naturally and experimentally infected with Haemophilus parasuis . (iastate.edu)
  • The spo0K locus of Bacillus subtilis is homologous to the oligopeptide permease locus and is required for sporulation and competence. (wikidata.org)
  • Proton oligopeptide cotransporter. (nih.gov)
  • Multiple charge-separation sites have successfully been constructed using supramolecular complexes of multiporphyrinic oligopeptides [P(ZnP) n , n = 2, 4, 8] with fulleropyrrolidine bearing a pyridine or imidazole coordinating ligand , which are organized by utilizing π-π interaction in addition to the coordination bond. (rsc.org)
  • In the first example, supramolecular complexes are formed between flexible zinc porphyrinic oligopeptides and fulleropyrrolidine bearing either a pyridine or imidazole functionalized C60 via a coordination bond plus π-π interactions. (wichita.edu)
  • The charge separation (CS) lifetimes of the supramolecular oligopeptide complexes have been elongated by increasing the generation of the porphyrins, enabling us to attain the longest lifetime (0.84 ms) for the P(ZnP)8-ImC60 supramolecular system in PhCN solution at 298 K, ever reported for supramolecular complexes. (wichita.edu)
  • Brace yourselves for the new age of regeneration with DR HAACH Oligopeptides Marine Revival Essence! (haach.com)
  • Dr HAACH Oligopeptides Marine Revival Essence is gentle on skin, suitable for sensitive skin. (haach.com)
  • Apply Oligopeptides Marine Revival Essence in the morning and evening, after Dr HAACH Cleanser and MicroTreatment Lotion. (haach.com)
  • Dispense 5 to 6 drops of Oligopeptides Marine Revival Essence on your palm or on a cotton pad. (haach.com)
  • The last ingredient is glycyl-alanyl-lysine-l-glutamine in the form of Oligopeptide-Enzymatic Technology . (supplementcritic.com)
  • Mindful that chronic hydroquinone use can cause ochronosis (permanent darkening), she has patients alternate with a nonhydroquinone bleaching agent such as lignin peroxidase, oligopeptide, Lytera, Melaplex, 4-n-butylresorcinol, Cysteamine cream, tranexamic acid, or oral antioxidants. (medscape.com)
  • This vector can be conveniently used to construct libraries of oligopeptides with a random amino acid sequence. (nih.gov)
  • A possible role that might have been played by ordered clusters at interfaces for the generation of homochiral oligopeptides under prebiotic conditions has been probed by a catalyzed polymerization of amphiphilic activated a-amino acids, in racemic and chiral non-racemic forms, which had self-assembled into two-dimensional (2D) ordered crystallites at the air-aqueous solution interface. (dtu.dk)
  • An efficient chiral amplification was obtained in the polymerization of nonracemic mixtures of C-18-Glu-NCA since the monomer molecules in the racemic 2D crystallites are oriented such that the reaction occurs between heterochiral molecules related by glide symmetry to yield heterochiral oligopeptides whereas the enantiomer in excess, in the enantiomorphous crystallites, yield oligopeptides of a single handedness. (dtu.dk)
  • Split of chiral degeneracy in mechanical and structural properties of oligopeptide-polysaccharide biomaterials. (academictree.org)
  • The experimental relative abundance of oligopeptides with homochiral sequence generated from (R,S)-C-18-TE-Lys and (R,S)-C-18-TE-Glu, as determined by mass spectrometry on enantioselectively deuterium-labeled samples, was found to be significantly larger than that obtained from (R,S) C-18-thio-Glu which polymerizes randomly. (dtu.dk)
  • An antipeptide monoclonal antibody was used to affinity-purify phagemids exposing oligopeptides which can interact with the monoclonal antibody. (nih.gov)
  • A series of monocationic lexitropsins, or information-reading oligopeptides, were synthesized to minimize and offset the AT bias for doubly cationic ligands bound in the minor groove of DNA. (syr.edu)
  • Bumps: Renewing oligopeptides help minimize the look of bumpiness. (target.com)
  • It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (uniprot.org)
  • Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. (nih.gov)