A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Peptides composed of between two and twelve amino acids.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
Substances and materials manufactured for use in various technologies and industries and for domestic use.
Formal voluntary or governmental procedures and standards required of hospitals and health or other facilities to improve operating efficiency, and for the protection of the consumer.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
A water-soluble medicinal preparation applied to the skin.
The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.
A frozen dairy food made from cream or butterfat, milk, sugar, and flavorings. Frozen custard and French-type ice creams also contain eggs.
A hypnotic and sedative used in the treatment of INSOMNIA.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Diminished or absent ability of a female to achieve conception.
Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products.
Measurement of light given off by fluorescein in order to assess the integrity of various ocular barriers. The method is used to investigate the blood-aqueous barrier, blood-retinal barrier, aqueous flow measurements, corneal endothelial permeability, and tear flow dynamics.
A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.
The gamete-producing glands, OVARY or TESTIS.
Inability to reproduce after a specified period of unprotected intercourse. Reproductive sterility is permanent infertility.
A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.
Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.
The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Devices used for influencing tooth position. Orthodontic appliances may be classified as fixed or removable, active or retaining, and intraoral or extraoral. (Boucher's Clinical Dental Terminology, 4th ed, p19)
Substances which pollute the soil. Use for soil pollutants in general or for which there is no specific heading.
Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.
Individual's rights to obtain and use information collected or generated by others.
A publication issued at stated, more or less regular, intervals.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.
The interactions between a host and a pathogen, usually resulting in disease.
Techniques utilizing cells that express RECOMBINANT FUSION PROTEINS engineered to translocate through the CELL MEMBRANE and remain attached to the outside of the cell.
Viruses whose hosts are bacterial cells.
Temperate bacteriophage of the genus INOVIRUS which infects enterobacteria, especially E. coli. It is a filamentous phage consisting of single-stranded DNA and is circularly permuted.
The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
Gastric analysis for determination of free acid or total acid.
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
Loss of water by diffusion through the skin and by evaporation from the respiratory tract.
A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
The application of engineering principles and methods to living organisms or biological systems.
The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
Oleagenous substances used topically to soothe, soften or protect skin or mucous membranes. They are used also as vehicles for other dermatologic agents.
The functions of the skin in the human and animal body. It includes the pigmentation of the skin.

Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors. (1/10855)

The terminal colon is aganglionic in mice lacking endothelin-3 or its receptor, endothelin B. To analyze the effects of endothelin-3/endothelin B on the differentiation of enteric neurons, E11-13 mouse gut was dissociated, and positive and negative immunoselection with antibodies to p75(NTR )were used to isolate neural crest- and non-crest-derived cells. mRNA encoding endothelin B was present in both the crest-and non-crest-derived cells, but that encoding preproendothelin-3 was detected only in the non-crest-derived population. The crest- and non-crest-derived cells were exposed in vitro to endothelin-3, IRL 1620 (an endothelin B agonist), and/or BQ 788 (an endothelin B antagonist). Neurons and glia developed only in cultures of crest-derived cells, and did so even when endothelin-3 was absent and BQ 788 was present. Endothelin-3 inhibited neuronal development, an effect that was mimicked by IRL 1620 and blocked by BQ 788. Endothelin-3 failed to stimulate the incorporation of [3H]thymidine or bromodeoxyuridine. Smooth muscle development in non-crest-derived cell cultures was promoted by endothelin-3 and inhibited by BQ 788. In contrast, transcription of laminin alpha1, a smooth muscle-derived promoter of neuronal development, was inhibited by endothelin-3, but promoted by BQ 788. Neurons did not develop in explants of the terminal bowel of E12 ls/ls (endothelin-3-deficient) mice, but could be induced to do so by endothelin-3 if a source of neural precursors was present. We suggest that endothelin-3/endothelin B normally prevents the premature differentiation of crest-derived precursors migrating to and within the fetal bowel, enabling the precursor population to persist long enough to finish colonizing the bowel.  (+info)

Primary haemostasis: sticky fingers cement the relationship. (2/10855)

Platelet aggregation to form a haemostatic plug, or thrombus, plays a key role in preventing bleeding from a wound. Recent studies have provided new insights into how platelet receptors are deployed during the interactions with the vascular subendothelial matrix that lead to haemostatic plug formation.  (+info)

Bcl-2 regulates amplification of caspase activation by cytochrome c. (3/10855)

Caspases, a family of specific proteases, have central roles in apoptosis [1]. Caspase activation in response to diverse apoptotic stimuli involves the relocalisation of cytochrome c from mitochondria to the cytoplasm where it stimulates the proteolytic processing of caspase precursors. Cytochrome c release is controlled by members of the Bcl-2 family of apoptosis regulators [2] [3]. The anti-apoptotic members Bcl-2 and Bcl-xL may also control caspase activation independently of cytochrome c relocalisation or may inhibit a positive feedback mechanism [4] [5] [6] [7]. Here, we investigate the role of Bcl-2 family proteins in the regulation of caspase activation using a model cell-free system. We found that Bcl-2 and Bcl-xL set a threshold in the amount of cytochrome c required to activate caspases, even in soluble extracts lacking mitochondria. Addition of dATP (which stimulates the procaspase-processing factor Apaf-1 [8] [9]) overcame inhibition of caspase activation by Bcl-2, but did not prevent the control of cytochrome c release from mitochondria by Bcl-2. Cytochrome c release was accelerated by active caspase-3 and this positive feedback was negatively regulated by Bcl-2. These results provide evidence for a mechanism to amplify caspase activation that is suppressed at several distinct steps by Bcl-2, even after cytochrome c is released from mitochondria.  (+info)

C/EBPalpha regulates generation of C/EBPbeta isoforms through activation of specific proteolytic cleavage. (4/10855)

C/EBPalpha and C/EBPbeta are intronless genes that can produce several N-terminally truncated isoforms through the process of alternative translation initiation at downstream AUG codons. C/EBPbeta has been reported to produce four isoforms: full-length 38-kDa C/EBPbeta, 35-kDa LAP (liver-enriched transcriptional activator protein), 21-kDa LIP (liver-enriched transcriptional inhibitory protein), and a 14-kDa isoform. In this report, we investigated the mechanisms by which C/EBPbeta isoforms are generated in the liver and in cultured cells. Using an in vitro translation system, we found that LIP can be generated by two mechanisms: alternative translation and a novel mechanism-specific proteolytic cleavage of full-length C/EBPbeta. Studies of mice in which the C/EBPalpha gene had been deleted (C/EBPalpha-/-) showed that the regulation of C/EBPbeta proteolysis is dependent on C/EBPalpha. The induction of C/EBPalpha in cultured cells leads to induced cleavage of C/EBPbeta to generate the LIP isoform. We characterized the cleavage activity in mouse liver extracts and found that the proteolytic cleavage activity is specific to prenatal and newborn livers, is sensitive to chymostatin, and is completely abolished in C/EBPalpha-/- animals. The lack of cleavage activity in the livers of C/EBPalpha-/- mice correlates with the decreased levels of LIP in the livers of these animals. Analysis of LIP production during liver regeneration showed that, in this system, the transient induction of LIP is dependent on the third AUG codon and most likely involves translational control. We propose that there are two mechanisms by which C/EBPbeta isoforms might be generated in the liver and in cultured cells: one that is determined by translation and a second that involves C/EBPalpha-dependent, specific proteolytic cleavage of full-length C/EBPbeta. The latter mechanism implicates C/EBPalpha in the regulation of posttranslational generation of the dominant negative C/EBPbeta isoform, LIP.  (+info)

Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity. (5/10855)

Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respective TCRs, showing that a single saccharide residue can be accommodated in the standard TCR-MHC geometry. The models also reveal a possible molecular basis for the observed cross-reactivity patterns of the CTL clones, which appear to be influenced by the length of the CDR3 loop and the nature of the immunizing ligand.  (+info)

Role of endothelin in the increased vascular tone of patients with essential hypertension. (6/10855)

We investigated the possible role of endothelin in the increased vasoconstrictor tone of hypertensive patients using antagonists of endothelin receptors. Forearm blood flow (FBF) responses (strain-gauge plethysmography) to intraarterial infusion of blockers of endothelin-A (ETA) (BQ-123) and endothelin-B (ETB) (BQ-788) receptors, separately and in combination, were measured in hypertensive patients and normotensive control subjects. In healthy subjects, BQ-123 alone or in combination with BQ-788 did not significantly modify FBF (P=0.78 and P=0.63, respectively). In hypertensive patients, in contrast, BQ-123 increased FBF by 33+/-7% (P<0.001 versus baseline), and the combination of BQ-123 and BQ-788 resulted in a greater vasodilator response (63+/-12%; P=0.006 versus BQ-123 alone in the same subjects). BQ-788 produced a divergent vasoactive effect in the two groups, with a decrease of FBF (17+/-5%; P=0.004 versus baseline) in control subjects and transient vasodilation (15+/-7% after 20 minutes) in hypertensive patients (P<0.001, hypertensives versus controls). The vasoconstrictor response to endothelin-1 was slightly higher (P=0.04) in hypertensive patients (46+/-4%) than in control subjects (32+/-4%). Our data indicate that patients with essential hypertension have increased vascular endothelin activity, which may be of pathophysiological relevance to their increased vascular tone. In these patients, nonselective ETA and ETB blockade seems to produce a greater vasodilator effect than selective ETA blockade.  (+info)

99mTc-labeled vasoactive intestinal peptide receptor agonist: functional studies. (7/10855)

Vasoactive intestinal peptide (VIP) is a naturally occurring 28-amino acid peptide with a wide range of biological activities. Recent reports suggest that VIP receptors are expressed on a variety of malignant tumor cells and that the receptor density is higher than for somatostatin. Our aims were to label VIP with 99mTc--a generator-produced, inexpensive radionuclide that possesses ideal characteristics for scintigraphic imaging--and to evaluate 99mTc-VIP for bioactivity and its ability to detect experimental tumors. METHODS: VIP28 was modified at the carboxy terminus by the addition of four amino acids that provided an N4 configuration for a strong chelation of 99mTc. To eliminate steric hindrance, 4-aminobutyric acid (Aba) was used as a spacer. VIP28 was labeled with 1251, which served as a control. Biological activity of the modified VIP28 agonist (TP3654) was examined in vitro using a cell-binding assay and an opossum internal anal sphincter (IAS) smooth muscle relaxivity assay. Tissue distribution studies were performed at 4 and 24 h after injection, and receptor-blocking assays were also performed in nude mice bearing human colorectal cancer LS174T. Blood clearance was examined in normal Sprague-Dawley rats. RESULTS: The yield of 99mTc-TP3654 was quantitative, and the yields of 125I-VIP and 1251-TP3654 were >90%. All in vitro data strongly suggested that the biological activity of 99mTc-TP3654 agonist was equivalent to that of VIP28. As the time after injection increased, radioactivity in all tissues decreased, except in the receptor-enriched tumor (P = 0.84) and in the lungs (P = 0.78). The tumor uptake (0.23 percentage injected dose per gram of tissue [%ID/g]) was several-fold higher than 125I-VIP (0.06 %ID/g) at 24 h after injection in the similar system. In mice treated with unlabeled VIP or TP3654, the uptake of 99mTc-TP3654 decreased in all VIP receptor-rich tissues except the kidneys. The blood clearance was biphasic; the alpha half-time was 5 min and the beta half-time was approximately 120 min. CONCLUSION: VIP28 was modified and successfully labeled with 99mTc. The results of all in vitro examinations indicated that the biological activity of TP3654 was equivalent to that of native VIP28 and tumor binding was receptor specific.  (+info)

Stimulation of phosphorylase kinase autophosphorylation by peptide analogs of phosphorylase. (8/10855)

Autoactivation of phosphorylase kinase in the presence of substrates has been studied to determine the cause of the hysteresis, or lag, in the phosphorylase kinase reaction. Peptide analogs corresponding to the convertible serine region of phosphorylase have been used as low molecular weight alternative substrates. Autophosphorylation of the kinase molecule was measured under conditions that favored autoactivation. Phosphorylase b and a tetradecapeptide, which was found to be a good model of phosphorylase, stimulated autoactivation by 86- and 37-fold, respectively. The tetradecapeptide also stimulated autophosphorylation of subunits A and B of the kinase molecule. This increased autophosphorylation coincided with an increased ability to convert phosphorylase. This finding supports the hypothesis that autophosphorylation is responsible for the lag in the phosphorylase kinase reaction. No evidence was obtained to suggest that the lag could be due to dissociation of the kinase. The stoichiometry of phosphate incorporation into phosphorylase kinase subunits by autophosphorylation was much greater than that reported to occur by protein kinase phosphorylation. Multiple phosphorylation sites in subunit A accounted for most of the phosphate incorporation during autophosphorylation. Saturating levels of hexa- and octapeptide analogs also caused stimulation of autophosphorylation. Possible mechanisms and experimental implications of substrate-stimulated autophosphorylation are discussed. Consideration also is given to the possible role of effectors in autophosphorylation in vivo.  (+info)

In vivo response to growth hormone-releasing peptide-6 in adrenocorticotropin-dependent Cushings syndrome by lung carcinoid tumor is associated with growth hor
Shop Trypsin-modulating oostatic factor ELISA Kit, Recombinant Protein and Trypsin-modulating oostatic factor Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Purpose: Stroke is the second cause of mortality worldwide, with a high incidence of disability in survivors. Promising candidate drugs have failed in stroke trials. Combined therapies are attractive strategies that simultaneously target different po
The RGD peptide is the binding motif of fibronectin to cell adhesion molecules. RGD peptide acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins. In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion. ...
Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.
Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane.
Sequences of human proteins are frequently prepared as synthetic oligopeptides to assess their functional ability to act as compounds modulating pathways involving the parent protein. Our objective was to analyze a set of oligopeptides, to determine if their solubility or activity correlated with features of their primary sequence, or with features of properties inferred from three-dimensional structural models derived by conformational searches. We generated a conformational database for a set of 78 oligopeptides, derived from human proteins, and correlated their 3D structures with solubility and biological assay activity (as measured by platelet activation and inhibition). Parameters of these conformers (frequency of coil, frequency of turns, the degree of packing, and the energy) did not correlate with solubility, which was instead partly predicted by two measures obtained from primary sequence analysis, that is, the hydrophobic moment and the number of charges. The platelet activity of ...
Sequences of human proteins are frequently prepared as synthetic oligopeptides to assess their functional ability to act as compounds modulating pathways involving the parent protein. Our objective was to analyze a set of oligopeptides, to determine if their solubility or activity correlated with features of their primary sequence, or with features of properties inferred from three-dimensional structural models derived by conformational searches. We generated a conformational database for a set of 78 oligopeptides, derived from human proteins, and correlated their 3D structures with solubility and biological assay activity (as measured by platelet activation and inhibition). Parameters of these conformers (frequency of coil, frequency of turns, the degree of packing, and the energy) did not correlate with solubility, which was instead partly predicted by two measures obtained from primary sequence analysis, that is, the hydrophobic moment and the number of charges. The platelet activity of ...
Results: 178 patients (pts) were observed for 1-81 (median 16.5, IQR 7-27) months totaling 325 patient years. Mean age at switch was 44 years, mean weight 76 kg, mean CD4 516 cells/mm3. Duration of preceding viral suppression was 0 - 177 (median 18, IQR 7-38) months. Most common preceding regimen was ATV/r+TDF+FTC (89 pts). Most common reasons given for switching to ATV+TDF+FTC were simplification (83 pts), dyslipidemia (17), gastrointestinal toxicity (10), coronary risk (10), CNS toxicity (10), hyperbilirubinemia (6 ...
Get Oligopeptides at Spectrum Chemical. SpectrumChemical.com carries a full line of fine chemicals, lab appliances and lab supplies. Spectrum Chemical offers fine chemicals in lab and production sizes.
An FDA snapshot analysis determined sub-50-copy 48-week response rates of 90% with Quad and 87% with atazanavir, a result establishing the virologic noninferiority of Quad in previously untreated people. A missing-data-equals-failure analysis determined sub-50-copy rates of 92% with Quad and 88% with atazanavir. Among people with a pretreatment viral load above 100,000 copies, 50-copy response rates were 85% with Quad and 82% with atazanavir; respective response rates in those starting treatment with at CD4 count at or below 350 were 89% and 88%. CD4 counts rose by an average 207 with Quad and 211 with atazanavir ...
-Viral cure rates of 92 and 88 with 24 and 48-week regimens, respectively, in people who met certain response criteria- -Safety and tolerability results were si
JPT Peptide Technologies is a DIN ISO 9001:2015 certified and GCLP compliant integrated provider of innovative peptide based catalog products and custom services.
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Description of the drug Atazanavir Sulfate. - patient information, description, dosage and directions. What is Atazanavir Sulfate!
Buy Atazanavir Online! Atazanavir is also sometimes used to prevent infection in healthcare workers or other people who were accidentally exposed to HIV. Talk to your doctor about the risks of using this medication for your condition. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Buy Atazanavir Online! Atazanavir is also sometimes used to prevent infection in healthcare workers or other people who were accidentally exposed to HIV. Talk to your doctor about the risks of using this medication for your condition. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Title: MedicineNet atazanavir Specialty, Description: MedicineNet atazanavir Specialty, By: Feedage Forager, ID: 331052, Grade: 91, Type: RSS20
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Účinky Hexarelin-u: Hexarelin najúčinnejšie stimuluje sekréciu rastového hormónu spomedzi všetkých GHRP (GHR peptidov) Hexarelin významne
Learn what medical issues to discuss with the doctor before taking REYATAZ® (atazanavir) as part of an HIV-1 treatment regimen. Read risk information and full Prescribing Information.
Get answers to frequently asked questions about HIV and about EVOTAZ® (atazanavir/cobicistat). Read risk info and full Prescribing Information.
Can you name the facts about the Fahrenheit temperature scale? Test your knowledge on this science quiz to see how you do and compare your score to others. Quiz by Anne13
TY - JOUR. T1 - Inhibition of angiogenesis in vitro and in vivo. T2 - Comparison of the relative activities of triflavin, an Arg-Gly-Asp-containing peptide and anti-α(v)β3 integrin monoclonal antibody. AU - Sheu, Joen Rong. AU - Yen, Mao Hsiung. AU - Kan, Ya Chen. AU - Hung, Wei Chun. AU - Chang, Pei Te. AU - Luk, Hsiang Ning. PY - 1997/10/20. Y1 - 1997/10/20. N2 - Disintegrin which contains the amino acid sequence Arg-Gly-Asp (RGD), has been implicated as a recognition site in interactions between extracellular matrix (ECM) and cell membrane receptors. Triflavin, a 7.5 kDa cysteine-rich polypeptide purified from Trimeresurus flavoviridis snake venom, belongs to a family of disintegrins. Integrin α(v)β3 has recently been identified as a marker of angiogenic blood vessels and therefore anti-α(v)β3 mAb may significantly inhibit angiogenesis. Therefore, this study was designed to compare the relative activity of triflavin and anti-α(v)β3 mAb in human umbilical vein endothelial cell (HUVEC) ...
The results of the IMPAACT/PACTG 1020A trial in children and adolescents indicate that, in the absence of ritonavir boosting, atazanavir can achieve protocol-defined PK targets-but only when used at higher doses of atazanavir (on a mg/kg body weight or mg/m2 body surface area basis) than doses currently recommended in adults. In IMPAACT/PACTG 1020A, children aged ,6 to ,13 years required atazanavir dosing of 520 mg/m2 per day of atazanavir capsule formulation to achieve PK targets.8 Unboosted atazanavir at this dose was well tolerated in those aged ,13 years who were able to swallow capsules.11 Doses required for older adolescents were greater than the adult approved dose of 400 mg atazanavir given without ritonavir boosting once daily; adolescents aged ,13 years required atazanavir dosing of 620 mg/m2 per day.8 In this study, the AUCs for the unboosted arms were similar to the ATV/r groups but the maximum plasma concentration (Cmax) was higher and minimum plasma concentration (Cmin) lower for ...
This study was aimed to determine the anticancer efficacy of the combination of paclitaxel, the standard treatment of breast cancer, and carfilzomib, ..
Role of RGD-binding integrins in uPAR-induced protrusions and adhesion. (A) Swiss 3T3 cells were injected with pRc/CMV-uPAR (100 μg/ml) and incubated in growth
3762 In its normal life cycle, B. pertussis attaches to, and invades ciliated epithelia and macrophages of the human airways, using adhesins specialized for certain oligosaccharides and proteins on these cells. Here we report that B. pertussis uses similar mechanisms for invasion of a variety of human cancer cells in vitro, and exhibits potent, invasion-dependent, cytotoxicity. In a 30′ in vitro invasion assay, B. pertussis invaded human SKmel-23 melanoma cells at 20-30 times the rate for normal human melanocytes and fibroblasts. B. pertussis invasion of SKmel-23 cells was inhibited by preincubation of cancer cells with glycosidase F, the plant lectins LPHA and TGP, human antibodies vs CD15 and CD11b, or the RGD tripeptide sequence-implying that the structural requirements for invasion included β1,6-branched N-glycans, Lewis × antigens, CD11b, and the sequence arg-gly-asp respectivelly. Invasion was also inhibited by preincubation of cancer cells with 3-methyladenine (3-MA), indicating a ...
預計在今年(2011)暑假通過 FDA 核准的 C 型肝炎強效新藥,Merck 藥廠的 boceprevir 與 Vertex Pharmaceuticals Inc. 藥廠的 telaprevir,FDA諮詢委員會(advisory committee)在四月27日與28日分別舉行會議,對藥物的安全性進行評估。. Telaprevir 與 Boceprevir 皆為針對第一基因型慢性 C 型肝炎的藥物,適用於未曾接受過治療、或對先前治療無效、但肝臟仍舊具有執行功能的患者(compensated stage)。. 與目前 C 型肝炎的臨床治療藥物相較之下,Telaprevir與Boceprevir有更強的治療效果,不過,卻也有較嚴重的副作用。現行的 C 肝藥物多半只會引起類似流感的副作用,而 Boceprevir 的潛在副作用則包括貧血、以及多個出現精神疾患的案例,精神疾患包括有自殺或殺人的傾向。. 由於使用 Boceprevir 治療 C 型肝炎的處方中,必須同時搭配使用長效型干擾素(peginterferon ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
A treatment regimen containing the experimental hepatitis C virus (HCV) antiviral telaprevir can cure HCV after 24 weeks of treatment, without requiring a full 48-week course of therapy, in people with HCV genotype 1 who have undetectable virus levels after 4 and 12 weeks of therapy. These early results from a clinical trial conducted by Vertex Pharmaceuticals were reported in a press release from the company.
Endomorphin (EM)-1 and EM-2 are tetrapeptides located within the mammalian central nervous system and immune tissues, with high affinity and specificity for μ-opioid receptors. Most of the literature...
In this study we focused on the signaling of V antigen-induced innate immunity responses. For the first time we demonstrate that a bacterial nonlipidated protein associated with virulence and derived synthetic oligopeptides are capable to induce IL-10 production via TLR2/CD14 signaling. In contrast to the pseudomonas rPcrV, rLcrV (range of activity: 10-100 nM) transmits signaling via TLR2 in a CD14-dependent manner leading to IL-10 induction which finally causes TNF-α suppression thus probably enabling yersiniae to evade the host innate immune system. Several lines of evidence obtained in vitro both in murine and human cell systems support this conclusion: (a) Only CD14-TLR2-cotransfected HEK 293 cells, but not cells transfected with TLR2 alone responded with NF-κB-dependent ELAM-1 promoter luciferase activity upon rLcrV stimulation. (b) Blocking anti-CD14 monoclonal antibodies, but not nonblocking isotype anti-CD14 antibodies completely abolished TNF-α suppression in LcrV-treated MonoMac-6 ...
As we aim towards enhancing our knowledge of complex cell behaviors and developing intricate cell-based devices and improved therapeutics, it becomes imperative that we be able to control and manipula
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InCELLect™ St-Ht31P Control Peptide is a stearated form of the peptide Ht-31P. This peptide has been used as a negative control peptide for the study of InCELLect™ AKAP St-Ht31 Inhibitor Peptide.
CLINICAL TRIAL ASSESSING ONCE DAILY RALTEGRAVIR ADMINISTRATION (800 mg QD) IN HIV-1-INFECTED PATIENTS RECEIVING UNBOOSTED ATAZANAVIR (400 mg QD)-BASED ANTIRETROVIRAL THERAPY (ENSAYO CLÍNICO PARA EVALUAR LA ADMINISTRACIÓN DE RALTEGRAVIR UNA VEZ AL DÍA (800 mg QD) EN PACIENTES INFECTADOS POR EL VIH-1 QUE RECIBEN TERAPIA ANTIRETROVIRAL BASADA EN ATAZANAVIR NO POTENCIADO (400 mg QD ...
Second, Table 3 in the article, outlining the toxicity associated with the regimens, is a gem. This is how we would like adverse events reported. From this table, it is apparent that it is important to keep in mind the small but definite risk of hypertension, dyspnea, and cardiac failure associated with carfilzomib. On the other hand, the risk of neuropathy is definitely lower with this drug compared with bortezomib. Finally, a comparison of overall survival results from other randomized trials in the relapsed setting (outlined well in the discussion section of the article) shows it is extremely difficult to achieve this magnitude of survival benefit, even with trials that lacked an active control equivalent. This reveals the value of carfilzomib as an added option for the treatment of myeloma. Take-Home Points HOW DO THE ENDEAVOR RESULTS change our current practice? With a definitive improvement in overall survival, ENDEAVOR ensconces the safety and efficacy of carfilzomib and provides evidence ...
Healthy 99% Human-Peptide 87616-84-0 Polypeptide Hormones GHRP-6 GHRP-6,releasing peptide-6 (GHRP-6) is in the category of drugs known as GH Secretagogues. This category of drugs includes GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. Their primary...
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DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Chosen biweekly by Rachel Grabenhofer, editor of Cosmetics Toiletries magazine, for their relevance to personal care, Patent Picks are taken from publicly available sources. This edition features recently issued patents related to sensates, feel enhancers and other physical/visual cues in personal care.
Chosen biweekly by Rachel Grabenhofer, editor of Cosmetics Toiletries magazine, for their relevance to personal care, Patent Picks are taken from publicly available sources. This edition features recently issued patents related to sensates, feel enhancers and other physical/visual cues in personal care.
Donne DG, Viles JH, Groth D, Mehlhorn I, James TL, Cohen FE, Prusiner SB, Wright PE, Dyson HJ. Multiple solution conformations of the integrin-binding cyclic pentapeptide cyclo(-Ser-D-Leu-Asp-Val-Pro-). Analysis of the (phi, psi) space available to cyclic pentapeptides ...
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Gonzalez, P., Peluffo, H., Acarin, L., Villaverde, A., Gonzalez, B. and Castellano, B. (2012), Interleukin-10 overexpression does not synergize with the neuroprotective action of RGD-containing vectors after postnatal brain excitotoxicity but modulates the main inflammatory cell responses. J. Neurosci. Res., 90: 143-159. doi: 10.1002/jnr.22741 ...
ATAZANAVIR (at a za NA veer) is an antiretroviral medicine. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. It will not stop the spread of HIV to others.
3VB5: Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
Regulatpro® Bio je kaskadno fermentiran bio koncentrat, proizveden iz ekološkega sadja, zelenjave, oreščkov in začimb. Edinstven encimski napitek vsebuje vitalne dipeptide, tripeptide, oligopeptide, polifenole, flavonoide (fitokemikalije) in desnosučno mlečno kislino L(+). V patentiranem procesu kaskadne fermentacije se aktivne substance iz prvovrstnih naravnih virov razdrobijo v drobne delce, ki zagotavljajo visoko absorpcijo v obliki koncentriranega napitka Regulatpro® Bio.. ...
After reconsituting my last two batches of GHRP2, and letting them sit in the fridge for a while before initial injection, both times there were
Looking for online definition of alkaline blood serum in the Medical Dictionary? alkaline blood serum explanation free. What is alkaline blood serum? Meaning of alkaline blood serum medical term. What does alkaline blood serum mean?
This page was last modified 11:06, 29 October 2010 by Neil Hauge. Based on work by , Nitin Dahyabhai and David Williams and others.. ...
The cinchona alkaloids, certain oligopeptides. Synthetic catalysts derived from biomolecules. Hydrogen bonding catalysts, ...
... various N-formyl oligopeptides that, like FMLP, are either released by microbes and mitochondria or are analogs of those ... released by microbes and mitochondria; b) microbe-derived non-formyl oligopeptides; c) certain polypeptides that are associated ...
... oligopeptides such as N-Formylmethionine-leucyl-phenylalanine; and various proteins such as the amino acid 1 to 42 fragment of ...
Oligopeptide Fyles, Thomas Murray; Luong, Horace (2009). "Solid-phase synthesis of a library of linear oligoester ion-channels ...
PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton ... Gonzalez DE, Covitz KM, Sadée W, Mrsny RJ (1998). "An oligopeptide transporter is expressed at high levels in the pancreatic ... Adibi SA (2003). "Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease". Am. J. ... "Entrez Gene: SLC15A1 Solute carrier family 15 (oligopeptide transporter), member 1". Liang R, Fei YJ, Prasad PD, Ramamoorthy S ...
... alpha-oligopeptides". The FEBS Journal. 273 (23): 5261-72. doi:10.1111/j.1742-4658.2006.05519.x. PMID 17064315. S2CID 84167461 ... beta-oligopeptides". Chemistry & Biodiversity. 3 (12): 1325-48. doi:10.1002/cbdv.200690136. PMID 17193247. S2CID 38292191. ... "Bacterial beta-peptidyl aminopeptidases with unique substrate specificities for beta-oligopeptides and mixed beta, ...
One example is oligopeptide P11-4. In dental orthopedics and implants, a more traditional strategy to improve the density of ...
Cooperman BS (2003). "Oligopeptide inhibition of class I ribonucleotide reductases". Biopolymers. 71 (2): 117-31. doi:10.1002/ ...
Changes in binding orientation also occur for facially-organized oligopeptides. This pattern is especially common in ... oligopeptides readily adopt stable α-helical structure. Furthermore, crosslinks can be incorporated into peptides to ...
Tandem repeats of short oligopeptides that are rich in glycine, proline, serine or threonine are capable of forming flexible ... Thus, these two codons and their respective amino acids must have been constituents of the earliest oligopeptides, with a ... Trifonov, Edward N. (September 2009). "The origin of the genetic code and of the earliest oligopeptides". Research in ... the early genetic code may have also produced low complexity oligo-peptides from valine and leucine. However, later on, within ...
The trypsin found in pancreatin works to hydrolyze proteins into oligopeptides; amylase hydrolyzes starches into ...
Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to ...
An oligopeptide, angiotensin is a hormone and a dipsogen. It is derived from the precursor molecule angiotensinogen, a serum ...
1995). "Self-complementary oligopeptide matrices support mammalian cell attachment". Biomaterials. 16 (18): 1385-1393. doi: ... 1993). "Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane" (PDF). Proc. Natl. ...
Blanco, Celia; Hochberg, David (2012). "Homochiral oligopeptides by chiral amplification: interpretation of experimental data ...
Many oligopeptides that possess an N-Formylmethionine N-terminal residue such as the prototypical tripeptide N-Formylmethionine ... Early studies suggested that these formyl oligopeptides operated by a Receptor (biochemistry) mechanism. Accordingly, the human ... function by binding any one of a wide variety of ligands including not only certain N-Formylmethionine-containing oligopeptides ... a gene that when transfected into FMLP-unresponsive cells bestowed responsiveness to this and other N-formyl oligopeptides. ...
This enzyme catalyses the following chemical reaction Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly ...
Unlike some AHLs, however, most oligopeptides do not act as transcription factors themselves. The free-living bioluminescent ... Gram-positive bacteria that participate in quorum sensing typically use secreted oligopeptides as autoinducers. Peptide ... Whereas Gram-negative bacteria primarily use acylated homoserine lactones, Gram-positive bacteria generally use oligopeptides ...
Instead, fMet-containing oligopeptides and proteins appear to be released by the mitochondria of damaged tissues as well as by ... fMet-containing oligopeptides and proteins also function in other physiological and pathological responses. Formyl peptide ... The prototypical fMet-containing oligopeptide is N-Formylmethionine-leucyl-phenylalanine (FMLP) which activates leukocytes and ... the fMet-containing oligopeptides and proteins are part of the innate immune system; they function to initiate acute ...
Daniel H, Kottra G (February 2004). "The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology". ... proton oligopeptide cotransporter (SLC15A1, SLC15A2, SLC15A3, SLC15A4) monocarboxylate transporter (SLC16A1, SLC16A2, SLC16A3, ...
Daniel H, Kottra G (2004). "The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology". Pflügers Arch. ... proton oligopeptide cotransporter (17) vesicular glutamate transporter (18) vesicular amine transporter (25) some mitochondrial ...
They are made of repeating units of a 1,2,3-triazole and an oligopeptide. They can be visualized as an oligopeptide that is ... The oligopeptide units of a clicked peptide polymer are a different story. The triazole bridges do not confer any stability to ... The first is the amidation of the oligopeptide's C-terminus by propargylamine. This would done with all other reaction groups ... The monomers used in this polymerization are oligopeptides with terminal azide and terminal alkyne groups To prepare and ...
In another array synthesis, Still generated a large library of oligopeptides by split synthesis. The drawback to making many ...
For a bacterial cell to reproduce through binary fission, more than a million peptidoglycan subunits (NAM-NAG+oligopeptide) ... Penicillin-binding proteins form the bonds between oligopeptide crosslinks in peptidoglycan. ...
The C-terminal contains 5 complete and one incomplete repeat of the Oligopeptide repeat sequence PQGGYQQ-YN. In modified ... Parham SN, Resende CG, Tuite MF (May 2001). "Oligopeptide repeats in the yeast protein Sup35p stabilize intermolecular prion ...
GcvB was shown to bind to Oppa and DppA which transport oligopeptides and dipeptides respectively. It has been shown to also ... "The gcvB gene encodes a small untranslated RNA involved in expression of the dipeptide and oligopeptide transport systems in ... "The gcvB gene encodes a small untranslated RNA involved in expression of the dipeptide and oligopeptide transport systems in ...
A particular case of endopeptidase is the oligopeptidase, whose substrates are oligopeptides instead of proteins. They are ...
Short 'oligopeptides', predominantly smaller than 30 amino acids in length, play essential roles as hormones, in the ... Among the products released by the non-lysosomal proteases are the bioactive oligopeptides such as hormones, neuropeptides and ... Camargo AC, Gomes MD, Reichl AP, Jacchieri SG, Juliano L (1997). "Structural features which make oligopeptides susceptible to ... is a good example of how an oligopeptidase interacts with and metabolizes an oligopeptide. The peptide has first to penetrate ...
These oligopeptides are known to be, or mimic the actions of, the N-formyl oligopeptides that are (a) released by tissue ... fMLF and a sampling of other, less potent, N-formyl oligopeptides were then found to stimulate a wide array of rabbit ... fMLF and other N-formylated oligopeptides were found to be similarly active in human neutrophils. The high degree of structural ... In further studies of various N-formylated oligopeptides, fMLF proved the most potent in stimulating rabbit neutrophil ...
Olling A, Goy S, Hoffmann F, Tatge H, Just I, Gerhard R (2011). "The repetitive oligopeptide sequences modulate cytopathic ... These short homologous repeating units have been termed combined repetitive oligopeptide (CROPs). A recent study demonstrates ...
An oligopeptide, often just called peptide (oligo-, "a few"), consists of two to twenty amino acids and can include dipeptides ... Netropsin - A basic oligopeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T ... Antipain - An oligopeptide produced by various bacteria which acts as a protease inhibitor. Ceruletide - A specific decapeptide ... Pepstatins - N-acylated oligopeptides isolated from culture filtrates of Actinomycetes, which act specifically to inhibit acid ...
Source for information on oligopeptide: A Dictionary of Plant Sciences dictionary. ... oligopeptide A linear peptide of 2-10 amino acids. Compare POLYPEPTIDE. ... www.encyclopedia.com/science/dictionaries-thesauruses-pictures-and-press-releases/oligopeptide ... www.encyclopedia.com/science/dictionaries-thesauruses-pictures-and-press-releases/oligopeptide ...
Renal oligopeptide reabsorption is the part of renal physiology that deals with the retrieval of filtered oligopeptides, ... Longer oligopeptides, such as angiotensin and glutathione are degraded by enzymes on the brush border, while shorter ones, such ...
Oligopeptide definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up ...
The present invention provides an oligopeptide which is represented by the formula (I): X1-X2-X3-X4-X5-X6-X7, or the like ... The object of the present invention is to provide an oligopeptide having hair growth promoting activity. ... As test oligopeptides, unmodified oligopeptides and modified oligopeptides produced in (1) above were used. ... There is preferably provided an oligopeptide shown in any one of the following sequences or a modified oligopeptide thereof:. ( ...
Characterization by Model Oligopeptides. In: Greenbaum L.M., Margolius H.S. (eds) Kinins IV. Advances in Experimental Medicine ...
Sericin-derived oligopeptides obtained from silk cocoons were investigated for the in vivo hypotensive effect and investigated ... Nevertheless, oligopeptides attenuated transient contractions in Ca2+-free medium containing EGTA (1 mM) induced by 1 µM PE, ... Hypotensive and Vasorelaxant Effects of Sericin-Derived Oligopeptides in Rats. Amnart Onsa-ard,1 Dawan Shimbhu,1 Jiraporn ... It is obvious that potent vasodilation effect of oligopeptides is mediated through both the endothelium and the vascular smooth ...
oligopeptide transporter 2. Locus tag. NCU07894. Gene type. protein coding. RNA name oligopeptide transporter 2. RefSeq status ... OPT; OPT oligopeptide transporter protein. cl00304. Location:62 → 145. TP_methylase; S-AdoMet dependent tetrapyrrole methylases ... NCU07894 oligopeptide transporter 2 [ Neurospora crassa OR74A ] Gene ID: 3877931, updated on 12-Oct-2017 ... XM_956690.3 → XP_961783.2 oligopeptide transporter 2 [Neurospora crassa OR74A]. See identical proteins and their annotated ...
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Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWGs strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED member companies that help to support the important work we do. Learn more , Legal Disclaimer ...
What Else You Need to Know: This dermatologist-developed, potent eye cream contains a unique combination of three oligo peptides ... What it is: A pro-level eye cream, with triple oligo peptides, that hydrates, firms, and smooths the appearance of eye skin ... SOBEL SKIN RxOligo Peptide Eye Cream. SIZE 0.5 oz/ 15 mL•ITEM 2274983 ... Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Dipeptide-2, Hesperidin Methyl Chalcone, Palmitoyl Tripeptide-5, Panthenol, ...
Oligopeptide transport system, conserved biosystem (from KEGG) Oligopeptide transport system, conserved biosystemStructural ... Oligopeptide transport system, organism-specific biosystem (from KEGG) Oligopeptide transport system, organism-specific ... periplasmic oligopeptide-binding protein. Locus tag. YPO2182. Gene type. protein coding. RefSeq status. REVIEWED. Organism. ... oppA periplasmic oligopeptide-binding protein [ Yersinia pestis CO92 ] Gene ID: 1175016, updated on 6-Sep-2017 ...
344-349 (36) 1990; Szejtli, J.: Pharmaceutical Technology International 16-22, 1991 that oligopeptides, particularly those with ...
Get Oligopeptides at Spectrum Chemical. SpectrumChemical.com carries a full line of fine chemicals, lab appliances and lab ... Oligopeptides Oligopeptides. Spectrum carries a wide assortment of oligopeptides which are peptides whose molecules contain a ... Spectrum specializes in providing the top oligopeptides but if you do not see the product, grade or form of the ingredient you ...
... H. Jungclas,1 L. Schmidt,1 V. V. ... A novel mass spectrometric method to analyse the sequence of amino acid residues in oligopeptides is proposed. Amino acid ... At specific grazing velocities the experimental fragment ion spectra of oligopeptides must contain a peak of high abundance ... This specific property of GMD offers the possibility to determine the amino acid sequence of oligopeptides. ...
The periplasmic oligopeptide-binding protein OppA has a remarkably broad substrate specificity, binding peptides of two or five ... The periplasmic oligopeptide-binding protein OppA has a remarkably broad substrate specificity, binding peptides of two or five ... OLIGOPEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH TRI-LYSINE. *DOI: 10.2210/pdb2OLB/pdb ... The crystal structures of the oligopeptide-binding protein OppA complexed with tripeptide and tetrapeptide ligands.. Tame, J.R. ...
PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN). A. 517. Salmonella enterica subsp. enterica serovar Typhimurium. Mutation(s): 0 Gene ... The Role of Water in Sequence-Independent Ligand Binding by an Oligopeptide Transporter Protein. Tame, J.R.H., Sleigh, S.H ... OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH KIK. *DOI: 10.2210/pdb1B3G/pdb ... This periplasmic binding protein, part of the oligopeptide permease system of Gram negative bacteria, has evolved to bind and ...
In this review we focus on the M13 oligopeptide phage display system for pathogen research but will also give examples for ... In recent years several new applications for oligopeptide phage display in disease related fields have been developed which has ... In addition, a detailed technical work flow for the identification of immunogenic oligopeptides using the pHORF system is given ... The described identification of immunogenic proteins of pathogens using oligopeptide phage display can be linked to antibody ...
Intestinal Absorption of Oligopeptides in Cystinuria. A. M. Asatoor, M. R. Crouchman, A. R. Harrison, F. W. Light, L. W. ... Intestinal Absorption of Oligopeptides in Cystinuria. A. M. Asatoor, M. R. Crouchman, A. R. Harrison, F. W. Light, L. W. ... Intestinal Absorption of Oligopeptides in Cystinuria Message Subject (Your Name) has forwarded a page to you from Clinical ... 1. The intestinal transport of oligopeptides containing either lysine or arginine has been compared with that of the ...
The determination of the gas-phase acidities of cysteine-containing oligopeptides is described. The experiments are performed ... We present a method to measure the acidities of oligopeptides in the gas-phase. We use a cysteine-containing oligopeptide, Ala3 ... Determination of the Gas-phase Acidities of Oligopeptides. Jianhua Ren1, Ashish Sawhney1, Yuan Tian1, Bhupinder Padda1, Patrick ... In this article, we use the oligopeptide Ala3CysNH2 (A3CH) as the model compound. The C-terminus is amidated and the thiol ...
A new way to store information in molecules could preserve the contents of the New York Public Library in a teaspoon of protein, without energy, for millions of years Books can burn. Compute... Read more ...
... a peptide and an oligopeptide? The answer is taken from an article written by Antonio Zamora. ... Oligopeptides have 10 or fewer amino acids. *Polypeptides and proteins are chains of 10 or more amino acids; however, peptides ...
OligoPeptide Synthesis , DiPeptide Synthesis , Tri-Peptide Synthesis. Selleck has been producing synthetic oligo peptides for ... Our experience in oligopeptide synthesis manufacturing allows us to produce the highest quality, large-scale oligopeptides with ... The following list provides details on oligopeptides we have recently synthesized.. Dipeptide. Tri-peptide. Oligopeptide. ... We have delivered more than 20,000 oligopeptides (including dipeptide, tri-peptide) to our customers. Our manufacturing ...
Additionally, the oligopeptide cream was not irritant according to 48 hr semi-occluded patch test. Conclusion Oligopeptide-20 ... Methods After randomization half the face of twenty volunteers was treated twice daily for two months with the oligopeptide-20 ... Sesc parameter, indicative of stratum corneum dehydration was affected almost equally by the oligopeptide and the vehicle cream ... No significant changes in transepidermal water loss values were demonstrated, indicating oligopeptide-20 does not affect the ...
"An oligopeptide transporter gene family in Arabidopsis.". Koh S., Wiles A.M., Sharp J.S., Naider F.R., Becker J.M., Stacey G.. ... "An oligopeptide transporter gene family in Arabidopsis.". Koh S., Wiles A.M., Sharp J.S., Naider F.R., Becker J.M., Stacey G.. ... "An oligopeptide transporter gene family in Arabidopsis.". Koh S., Wiles A.M., Sharp J.S., Naider F.R., Becker J.M., Stacey G.. ... Oligopeptide transporter 7Add BLAST. 766. Proteomic databases. PaxDb, a database of protein abundance averages across all three ...
... Nat Mater. 2014 Dec;13(12):1157-64. doi: 10.1038/ ... Here, we show that an adipocyte-targeting fusion-oligopeptide gene carrier consisting of an adipocyte-targeting sequence and 9- ... The ATS-9R/shFABP4 oligopeptide complex could prove to be a safe therapeutic approach to regress and treat obesity as well as ...
... ranging from oligopeptides for sensory properties and peptides for hair, to a dandruff treatment and colorless carotenoids for ... Oligopeptides in sensory: Evonik Goldschmidt discloses oligopeptide-containing dermatological compositions for increasing ... Oligopeptides in Sensory, Proteins in Winter Skin and Carotenoids: Literature Findings. June 20, 2013 , Contact Author , By: ... The oligopeptides can be acylated or biotinylated. An example is shown in Formula 1. ...
Oligopeptide Competition Assay for Phosphorylation Site Determination. Min Sung Joo1, Ja Hyun Koo1, Sol-Bi Shin2, Hyungshin Yim ... Prepare a reaction buffer on ice: 0.15 µg of AMPK, 0.4 µg of Nrf2 (~4 pmol), 0.43 mg of oligopeptide (~300 nmol), and 6 µL of 5 ... To overcome these challenges, an in vitro oligopeptide-competing kinase assay can be used for a protein kinase with known ... Joo, M. S., Koo, J. H., Shin, S. B., Yim, H., Kim, S. G. Oligopeptide Competition Assay for Phosphorylation Site Determination ...
... amino-acids and oligopeptides. This is a proof of principle of the possibility of the identification of various bioanalytes by ... Quantum Dots-Assisted 2D Fluorescence for Pattern Based Sensing of Amino Acids, Oligopeptides and Neurotransmitters by Marcin ... Keywords: pattern-based sensing; quantum dots; 2D fluorescence; neurotransmitters; oligopeptides; amino-acids; PLS-DA; EEM ... Zabadaj M, Ciosek-Skibińska P. Quantum Dots-Assisted 2D Fluorescence for Pattern Based Sensing of Amino Acids, Oligopeptides ...
Oligopeptides in fermented soymilk downregulated the expression stronger than that observed with soymilk. On the other hand, no ... The downregulation of FAS with oligopeptides from fermented soymilk was stronger than that from soymilk. In the present animal ... Therefore, we attempted to clarify the effects of isoflavones and oligopeptides in lactic acid-fermented soymilk on lipid ... In the present study, it was found that isoflavone aglycones and oligopeptides in fermented soymilk differentially regulate ...
  • Oligopeptide classes are produced by nonribosomal peptides synthases (NRPS), except cyclamides and microviridins are synthesized through ribosomic pathways. (wikipedia.org)
  • Examples of oligopeptides include: Amanitins - Cyclic peptides taken from carpophores of several different mushroom species. (wikipedia.org)
  • Spectrum carries a wide assortment of oligopeptides which are peptides whose molecules contain a relatively small number of amino-acid residues. (spectrumchemical.com)
  • The periplasmic oligopeptide-binding protein OppA has a remarkably broad substrate specificity, binding peptides of two or five amino-acid residues with high affinity, but little regard to sequence. (rcsb.org)
  • This periplasmic binding protein, part of the oligopeptide permease system of Gram negative bacteria, has evolved to bind and enclose small peptides of widely varying sequences. (rcsb.org)
  • This month's survey of recent patent and literature research describes money-making ideas in the personal care industry, ranging from oligopeptides for sensory properties and peptides for hair, to a dandruff treatment and colorless carotenoids for sun damage protection. (cosmeticsandtoiletries.com)
  • as well as a Mega-Rich Anti-Aging Sleeping Mask fueled by Proprietary FirmaCELL-4 which contains four different molecular size peptides: Syn-Coll, Palmitoyl Tetrapeptide-7, Palmitoyl Oligopeptide and neuropeptide Argireline to help firm, tone, smooth and clarify the look of skin, reducing the appearance of fine lines and the severity of deep wrinkles for younger looking skin. (thefreedictionary.com)
  • A particular blend of peptides (palmitoyl oligopeptide and palmitoyl tetrapeptide) works by helping tighten the delicate tissue. (thefreedictionary.com)
  • The present study was aimed at investigating the cholesterol-lowering effect of sericin peptides, so called "sericin-derived oligopeptides" (SDO) both in vivo and in vitro. (springer.com)
  • The crystal structures of the poly-Aib oligopeptide amides were established by X-ray crystallography confirming the 310-helical conformation of Aib peptides. (uzh.ch)
  • We investigated for the first time the oligopeptide diversity within a natural Microcystis population by analyzing single colonies directly with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). The results demonstrate a high diversity of known cyanobacterial peptides such as microcystins, anabaenopeptins, microginins, aeruginosins, and cyanopeptolins, but also many unknown substances in the Microcystis colonies. (pubmedcentralcanada.ca)
  • Short-chain peptides are transported across membranes through promiscuous proton-dependent oligopeptide transporters (POTs)-a subfamily of the major facilitator superfamily (MFS). (ntu.edu.sg)
  • Sperm surface protein Sp17, WAP four-disulfide core domain protein 2, müllerian-inhibiting substance, human proteome, low-similarity peptides, synthetic oligopeptide constructs, anti-ovarian cancer vaccines. (eurekaselect.com)
  • Interestingly, deep studies of the mechanisms of action of regulatory peptides showed that in many cases life-sustaining processes are regulated not by the total peptide molecules but their short-chained derivatives - oligopeptides that are produced in the course of limited proteolysis from proteins-precursors (cytokines, thymic peptides, immunoglobulins) [13,14,18,20,21]. (medcraveonline.com)
  • The seroreactivities to seven oligopeptides, representing T and B cell epitopes from the ring erythrocyte surface antigen (Pf155/RESA), the clustered arginine-rich protein antigen (CARP), and the circumsporozoite (CS) proteins were determined in the children at the start of the study and after 28 days. (ajtmh.org)
  • One only grape oligopeptide with antimicrobial function was extracted and characterized before (4) whereas information on numerous grape uncharacterized proteins has to be found in public protein databases. (thefreedictionary.com)
  • 2001. Functional testing of putative oligopeptide permease (Opp) proteins of Borrelia burgdorferi : a complementation model in opp- Escherichia coli. (koreascience.or.kr)
  • The term "oligopeptide" refers to proteins, composed of not more than 20 amino acid residues [22]. (medcraveonline.com)
  • Oligopeptide transporters (OPTs) are a group of membrane localized proteins that have a broad range of substrate transport capabilities and contribute to numerous biological processes. (preprints.org)
  • Our data suggest a model in which the oligopeptide repeats in Sup35p stabilize intermolecular interactions between Sup35p proteins that initiate establishment of the aggregated state. (kent.ac.uk)
  • An Investigation of Oligopeptides Linking Domains in Protein Tertiary Structures and Possible Candidates for General Gene Fusion" (PDF). (wikipedia.org)
  • Periplasmic protein associated with the oligopeptide permeases of Salmonella typhimurium and Escherichia coli. (asm.org)
  • The oligopeptide permease (Opp) of group A streptococci (GAS) is a membrane-associated protein and belongs to the ATP-binding cassette transporter family. (asm.org)
  • M. catarrhalis has a putative oligopeptide permease ABC transport operon ( opp ) consisting of five genes ( oppB , oppC , oppD , oppF , and oppA ), encoding two permeases, two ATPases, and a substrate binding protein. (asm.org)
  • Fish protein oligopeptide with low allergenicity and slight fishiness and industrial preparation method and. (patents.com)
  • Meanwhile, another report also demonstrated that, probiotics stimulate biotherapeutic protection mechanism through heat shock protein Hsp27 via oligopeptide transporter OCTN2 that protects the cells from oxidant mediated damage. (thefreedictionary.com)
  • Immunogenicity of a synthetic oligopeptide corresponding to antigenically common T-helper and B-cell neutralizing epitopes of the major outer membrane protein of Chlamydia trachomatis. (thefreedictionary.com)
  • These are responsible for oligopeptide binding protein (OppA), permease (OppB and OppC) and energy generation system (OppD and OppF), respectively. (koreascience.or.kr)
  • 2000. OppA of Listeria monocytogenes, an oligopeptide-binding protein required for bacterial growth at low temperature and involved in intracellular survival. (koreascience.or.kr)
  • 1996. Enterococcus faecalis pheromone binding protein, PrgZ, recruits a chromosomal oligopeptide permease system to import sex pheromone cCF10 for induction of conjugation. (koreascience.or.kr)
  • The multidirectional mechanisms of gastroprotective effects of oligopeptides are mediated by their involvement in the regulation of genes expression, DNA replication and protein biosynthesis, oxidative and reductive reactions, modulation of activity of hormones and enzymes, vessel permeability, neoangiogenesis, neuro- and immunomodulatory effects, influence on motility, secretion and production of gastric mucous. (medcraveonline.com)
  • Wheat oligopeptide was extracted from natural wheat protein, which was made from wheat-protein-rich wheat gluten. (smartpepcan.com)
  • Supplementing a certain amount of wheat oligopeptide can promote the growth of intestinal epithelial cells and improve protein absorption and utilization. (smartpepcan.com)
  • Supplementation of wheat oligopeptide effectively slows down the skeletal muscle protein content caused by exercise. (smartpepcan.com)
  • Clinically proven to reduce wrinkle depth by increasing hyaluronic acid and collagen production, Palmitoyl Oligopeptide (PO)is a synthetic protein that is a fragment of collagen combined with palmitic acid to make it more lipophillic, to improve its stability and to enhance its affinity towards human skin. (cellularskinrx.com)
  • Oligopeptide repeats in the yeast protein Sup35p stabilize intermolecular prion interactions. (kent.ac.uk)
  • The mammalian prion protein PrP also contains similar oligopeptide repeats and we show here that a human PrP repeat (PHGGGWGQ) is able functionally to replace a Sup35p oligopeptide repeat to allow stable [PSI(+)] propagation in vivo. (kent.ac.uk)
  • Our experience in oligopeptide synthesis manufacturing allows us to produce the highest quality, large-scale oligopeptides with a high success rate. (selleckchem.com)
  • For more information about our oligopeptide synthesis service, please visit our peptide synthesis webpage. (selleckchem.com)
  • In vitro studies revealed that oligopeptide-20 increases the proliferation rhythm of keratinocyte and fibroblasts, stimulates the collagen and hyalouronic acid synthesis by the fibroblasts and keratinocytes,decreases the apoptosis rhythm, increases the cells adhesion ability and improves the texture of cuticle. (syntides.com)
  • Structurally well-defined liquid crystalline oligopeptides based upon a side-chain mesogenically substituted L-lysine residue are prepared via solid phase peptide synthesis (SPPS). (strath.ac.uk)
  • Genome sequence data from multidrug-resistant USA300 strain FPR3757 showed that it has a novel mobile genetic element that contains genes for enzymes of the arginine deiminase pathway and an oligopeptide permease system (16). (thefreedictionary.com)
  • 2. The cyclic oligopeptide of claim 1 , wherein Y represents an amino acid sequence consisting of 1 to 12 amino acid residues. (google.es)
  • 3. The cyclic oligopeptide of claim 1 , wherein the linking group L contains 6 to 8 carbon atoms. (google.es)
  • 4. The cyclic oligopeptide of claim 1 , wherein a carbonyl group is bound to a hydrocarbon chain containing 5 to 7 carbon atoms in the linking group L. (google.es)
  • 5. The cyclic oligopeptide of claim 1 , wherein the linking group L is CO-(CH 2 ) n -NH- wherein n represents an integer between 5 and 7. (google.es)
  • 6. The cyclic oligopeptide of claim 5 , wherein -CO in the linking group L is bound to X1, and NH- in the linking group L is bound to the Cys residue binding to X6. (google.es)
  • 7. The cyclic oligopeptide of claim 1 wherein the cyclic oligopeptide promotes hair growth. (google.es)
  • 8. A medicament which comprises, as an active ingredient, a cyclic oligopeptide of claim 1 , or a physiologically acceptable salt thereof. (google.es)
  • Unfortunately, these mushrooms have no unique smell or taste characteristics, and cooking does not destroy the two types of cyclic oligopeptide toxins, the amatoxin and the phallotoxins. (thefreedictionary.com)
  • While essential fatty acids provide substantial photoprotection, an oil-soluble peptide called palmitoyl oligopeptide has been shown to kick start the repair process of sun-damaged skin by triggering new production of key molecules such as collagen and hyaluronic acid. (thefreedictionary.com)
  • Palmitoyl Oligopeptide 中文是(寡胜肽) 有促進膠原蛋白,彈力纖維和透 (cosdna.com)
  • ABC transporters have been shown to be important in the Agrobacterium tumefaciens response to opines ( 9 ), the competence of Streptococcus pneumoniae ( 14 ), and the uptake of oligopeptides of three to six amino acids in Salmonella enterica serovar Typhimurium, Bacillus subtilis , Lactococcus lactis , and Streptococcus agalactiae ( 7 , 21 , 42 ). (asm.org)
  • To monitor nitrate and peptide transport activity in vivo , we converted the dual-affinity nitrate transceptor CHL1/NRT1.1/NPF6.3 and four related oligopeptide transporters PTR1, 2, 4 and 5 into fluorescence activity sensors (NiTrac1, PepTrac). (biorxiv.org)
  • In particular, the dithiocarbamato moiety was functionalized with different oligopeptides of general formula [AuIIIX2(dtc-Sar/Aib-(AA)n)] (AA= different aminoacids), to be recognized and uptaken by specific peptide transporters called PEPTs (PEPT1 and PEPT2), predominantly present in epithelial cells of small intestine, mammary glands, lung, choroid plexus and kidney, and overexpressed in some tumor types. (unipd.it)
  • Guo, D. Genome-Wide Analysis of Oligopeptide Transporters Gene Family in Medicago truncatula . (preprints.org)
  • Sericin-derived oligopeptides obtained from silk cocoons were investigated for the in vivo hypotensive effect and investigated for the underlying mechanism involved in vasodilation in isolated rat thoracic aorta. (hindawi.com)
  • 2004. Identification of oligopeptide permease(opp) gene cluster in Vibrio fluvialis and characterization of biofilm production by oppA knockout mutation. (koreascience.or.kr)
  • A branched, synthetic oligopeptide corresponding to a region of glycoprotein G of HSV-1 reacts sensitively and specifically with HSV-1 antibodies in an ELISA. (thefreedictionary.com)
  • A synthetic oligopeptide derived from enamel matrix derivative promotes the differentiation of human periodontal ligament stem cells into osteoblast-like cells with increased mineralization. (semanticscholar.org)
  • The proton-coupled oligopeptide transporter (PEPT1) has been shown to mediate mucosal cell transport of di- and tripeptide, and some peptidomimetic drugs. (aspetjournals.org)
  • Complementary DNA clones encoding the rat PepT1 small-intestinal oligopeptide transporter were isolated from a jejunal library by cross-hybridization with a rabbit PepT1 cDNA probe. (nih.gov)
  • Oligopeptide transporter PepT1 in Atlantic cod (Gadus morhua L.): cloning, tissue expression and comparative aspects. (ualg.pt)
  • A novel full-length cDNA that encodes for the Atlantic cod (Gadus morhua L.) PepT1-type oligopeptide transporter has been cloned. (ualg.pt)
  • The present invention provides an oligopeptide which is represented by the formula (I): X1-X2-X3-X4-X5-X6-X7, or the like wherein X1 represents an amino acid residue such as Ser, X2 represents an. (google.es)
  • A novel mass spectrometric method to analyse the sequence of amino acid residues in oligopeptides is proposed. (hindawi.com)
  • At specific grazing velocities the experimental fragment ion spectra of oligopeptides must contain a peak of high abundance corresponding to the N-terminal amino acid. (hindawi.com)
  • This specific property of GMD offers the possibility to determine the amino acid sequence of oligopeptides. (hindawi.com)
  • The review summarizes current knowledge on oligopeptides (up to 20 amino acid residues) with documented gastroprotective properties and their possible mechanisms of action. (medcraveonline.com)
  • There is a need for useful and reliable rules for the rational design of oligopeptides that link amino-acid sequence to the resulting properties. (faccts.de)
  • Here, we show that an adipocyte-targeting fusion-oligopeptide gene carrier consisting of an adipocyte-targeting sequence and 9-arginine (ATS-9R) selectively transfects mature adipocytes by binding to prohibitin. (nih.gov)
  • And agents including these: -- Complement factor inhibition and serotonin modifiers -- Anti-integrin oligopeptide treatment -- Oligonucleotides and siRNA therapy -- Angiotensin receptor blockers and converting enzyme inhibitors -- Regenerative medicine, neural stem cells, cellular and gene therapies. (thefreedictionary.com)
  • Eight SLC gene families are involved in the transport of amino acids and oligopeptides. (reactome.org)
  • These processes of grazing molecule excitation (GME) and dissociation (GMD) were applied to analyse sequences of oligopeptides by using TOF mass spectrometry. (hindawi.com)
  • 0 outside oligopeptide site (parts of pre- and post-regions of all grape sequences were in Table 1 only). (thefreedictionary.com)
  • In this study, receptor-specific oligopeptide sequences derived from the extracellular matrix (ECM) molecule laminin, a potent neural cell attachment and differentiation promoter were covalently bound on fluorinated ethylene propylene (FEP) films. (epfl.ch)
  • The degree of receptor-specific cell attachment and the ability to spatially control neurite outgrowth by covalently patterning the oligopeptide sequences on the FEP film surface were assessed. (epfl.ch)
  • The spatial patterning of these oligopeptide sequences to the FEP surface was shown to localize cell attachment and neurite extension on the patterned pathways. (epfl.ch)
  • FEP films immobilized with the IKVAV oligopeptide sequence were shown to mediate PC12 cell attachment and a competitive binding medium also significantly attenuated cell attachment on the immobilized films. (epfl.ch)
  • We have delivered more than 20,000 oligopeptides (including dipeptide, tri-peptide) to our customers. (selleckchem.com)
  • The overall aim of this research work was to evaluate a series of dipeptide monoester prodrugs of an antiviral agent, ganciclovir (GCV), for oligopeptide transporter-targeted transscleral drug delivery to rabbit retina. (unboundmedicine.com)
  • 1. The intestinal transport of oligopeptides containing either lysine or arginine has been compared with that of the corresponding free amino acids in six homozygous cystinuric patients and in six normal adult subjects by use of the oral tolerance test technique. (clinsci.org)
  • Evonik Goldschmidt discloses oligopeptide-containing dermatological compositions for increasing sensory detection in skin. (cosmeticsandtoiletries.com)
  • The sponsor (ARDA), Manote Sutheerawattananonda, and Nanteetip Limpeanchob hold a patent WO2013/032411A1 in title silk-based bioactive oligopeptide compositions and manufacturing process thereof. (springer.com)
  • Oligopeptides containing the YIGSR sequence from the B1 chain of laminin and the water soluble oligopeptide containing the IKVAV sequence (CSRARKQAASIKVAVSADR) from the A chain were covalently bound to the hydroxylated FEP films. (epfl.ch)
  • The spatial immobilization of laminin oligopeptides on FEP films provides a means to organize the attachment and differentiation of neuronal cells in a receptor-specific manner. (epfl.ch)
  • The lips are perfectly hydrated, plumped up with a raw material that acts as a ceramide and oligopeptide known to stimulate collagen production. (thefreedictionary.com)
  • Holographic microscopy was used to record videos of swimming zoospores in the vicinity of surfaces with different cationic oligopeptide concentrations to provide time-resolved insights into processes associated with attachment of spores. (diva-portal.org)
  • Structural and functional insights into oligopeptide acqu. (au.dk)
  • This review summarizes experimental studies addressing structural features of tandem repeats of short oligopeptides that are rich in proline, glycine, asparagine, serine, and/or threonine. (eurekaselect.com)
  • The most explored gastroprotective oligopeptides, including opiates, pentadecapeptide BPC 157, proline- and hydroxyproline-containing products of collagen degradation, thymohexin and honluten are overviewed. (medcraveonline.com)
  • Longer oligopeptides, such as angiotensin and glutathione are degraded by enzymes on the brush border, while shorter ones, such as carnosine, are transported across the apical membrane as a whole by the PepT 1 transporter, and degraded inside the proximal tubule cell. (wikipedia.org)
  • Can non-hormone oligopeptides induce a functional imprinting? (portlandpress.com)
  • Dipeptides, angiotensin converting enzyme inhibitors, and a beta-lactum antibiotic strongly inhibited the transport of glycylsarcosine indicating the functional presence of oligopeptide transport (OPT) system on the RPE. (unboundmedicine.com)
  • The present invention relates to an oligopeptide having hair growth promoting activity and a medicament comprising the above oligopeptide as an active ingredient. (google.es)
  • Spectrum specializes in providing the top oligopeptides but if you do not see the product, grade or form of the ingredient you require, just contact our chemical specialist at [email protected] (spectrumchemical.com)
  • Conclusion Oligopeptide-20 could be a useful and safe ingredient of anti-aging cosmetics. (scirp.org)
  • Due to the modern knowledge oligopeptides realize their effect on the cellular, chromosomal, genomic and molecular levels. (medcraveonline.com)
  • It was established that low-weighing oligopeptides realize their effect on the cellular, chromosomal, genomic and molecular levels [13-21]. (medcraveonline.com)
  • Results and Conclusion: This study describes a methodology for constructing ovarian cancer biomarkerderived oligopeptide constructs that might induce powerful, specific, and non-crossreactive immune responses against ovarian cancer. (eurekaselect.com)
  • The oligopeptide low-molecular-weight chromium-binding substance (LMWCr) may function as part of a novel insulin-signaling autoamplification mechanism. (thefreedictionary.com)
  • Five oligopeptides-glycylglycine, glycyl-l-asparagine, glutathione, glycyl-l-prolyl-l-alanine, and glycyl-l-prolyl-glycyl-glycine-were crystallized epitaxially from solution on a variety of alkali halide (001) cleavage faces. (northwestern.edu)
  • Determination of Oligopeptide Diversity within a Natural Population of Microcystis spp. (pubmedcentralcanada.ca)
  • Oligopeptide patterns were mostly related to specific Microcystis taxa. (pubmedcentralcanada.ca)
  • The significance of oligopeptides as a chemotaxonomic tool within the genus Microcystis is discussed. (pubmedcentralcanada.ca)
  • The researchers demonstrate a deposition scheme, by which oligopeptides form long-range ordered nanostructures in two dimensions on a surface - despite the apparent complexity and flexibility of the underlying molecular building block. (faccts.de)
  • In normotensive anesthetized rats, oligopeptides induced an immediate and transient hypotensive activity. (hindawi.com)
  • ATP-dependent uptake was inhibited by several other oligopeptides, which in the case of EMD 51921 was competitive. (aspetjournals.org)
  • As a result of this comparison, poly(5-norbornene-2-carboxyl) was chosen as the backbone for the more complex oligopeptide containing polymers, and norbornene monomers with pendent EO_5 (21), GRGD (24), and SRN (25) units were made. (caltech.edu)
  • Topochemical Polymerization in Supramolecular Polymers of Oligopeptide-Functionalized Diacetylenes. (docme.ru)
  • Angewandte Chemie Supramolecular Polymers DOI: 10.1002/anie.200600610 Topochemical Polymerization in Supramolecular Polymers of Oligopeptide-Functionalized Diacetylenes** Eike Jahnke, Ingo Lieberwirth, Nikolai Severin, Jrgen P. Rabe, and Holger Frauenrath* New generations of synthetic polymers targeting applications at the interface of optoelectronics and the biosciences must "speak the language" of biomaterials and mimic their functioning. (docme.ru)
  • 15] Here we describe the use of self-assembled supramolecular polymers consisting of b-sheet-forming oligopeptides as scaffolds for the topochemical polymerization of diacetylenes in solution. (docme.ru)
  • A. Varvaresou, S. Papageorgiou, E. Protopapa and A. Katsarou, "Efficacy and Tolerance Study of an Oligopeptide with Potential Anti-Aging Activity," Journal of Cosmetics, Dermatological Sciences and Applications , Vol. 1 No. 4, 2011, pp. 133-140. (scirp.org)
  • Many small oligopeptides are rapidly excreted unchanged into bile, which requires vectorial transport across the hepatocyte. (aspetjournals.org)
  • Oligopeptide can be transported into cytoplasm by a specific transport system, Opp system. (koreascience.or.kr)
  • 2] Recently, the self-assembly of oligopeptides through aggregation and formation of b sheets has received increasing attention. (docme.ru)
  • In a decisive step towards this direction, researchers from the Max Planck Institute for Solid State Research in Stuttgart and the Ecole Polytechnique Federale in Lausanne propose an approach for obtaining microscopic understanding of the self-assembly of an oligopeptide. (faccts.de)