Chalones
Amino Acid Sequence
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Aminopeptidases
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Substrate Specificity
Cephalexin
Antibodies, Catalytic
Endopeptidases
Structure-Activity Relationship
Lactococcus lactis
Amino Acids
Leucyl Aminopeptidase
A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
Peptide Fragments
Alanine
Protease Inhibitors
Biological Transport
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
Proline
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Caseins
Peptide Hydrolases
Base Sequence
Chromatography, High Pressure Liquid
Hydrogen-Ion Concentration
Glycine
Binding Sites
Biological Transport, Active
Circular Dichroism
Stereoisomerism
Membrane Transport Proteins
Carrier Proteins
Magnetic Resonance Spectroscopy
Mass Spectrometry
Protons
Sequence Homology, Amino Acid
Cloning, Molecular
Models, Molecular
Serine Endopeptidases
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Recombinant Fusion Proteins
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Protein Binding
Protein Structure, Secondary
Rabbits
Temperature
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Cattle
Electrophoresis, Polyacrylamide Gel
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Dose-Response Relationship, Drug
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors. (1/10855)
The terminal colon is aganglionic in mice lacking endothelin-3 or its receptor, endothelin B. To analyze the effects of endothelin-3/endothelin B on the differentiation of enteric neurons, E11-13 mouse gut was dissociated, and positive and negative immunoselection with antibodies to p75(NTR )were used to isolate neural crest- and non-crest-derived cells. mRNA encoding endothelin B was present in both the crest-and non-crest-derived cells, but that encoding preproendothelin-3 was detected only in the non-crest-derived population. The crest- and non-crest-derived cells were exposed in vitro to endothelin-3, IRL 1620 (an endothelin B agonist), and/or BQ 788 (an endothelin B antagonist). Neurons and glia developed only in cultures of crest-derived cells, and did so even when endothelin-3 was absent and BQ 788 was present. Endothelin-3 inhibited neuronal development, an effect that was mimicked by IRL 1620 and blocked by BQ 788. Endothelin-3 failed to stimulate the incorporation of [3H]thymidine or bromodeoxyuridine. Smooth muscle development in non-crest-derived cell cultures was promoted by endothelin-3 and inhibited by BQ 788. In contrast, transcription of laminin alpha1, a smooth muscle-derived promoter of neuronal development, was inhibited by endothelin-3, but promoted by BQ 788. Neurons did not develop in explants of the terminal bowel of E12 ls/ls (endothelin-3-deficient) mice, but could be induced to do so by endothelin-3 if a source of neural precursors was present. We suggest that endothelin-3/endothelin B normally prevents the premature differentiation of crest-derived precursors migrating to and within the fetal bowel, enabling the precursor population to persist long enough to finish colonizing the bowel. (+info)Primary haemostasis: sticky fingers cement the relationship. (2/10855)
Platelet aggregation to form a haemostatic plug, or thrombus, plays a key role in preventing bleeding from a wound. Recent studies have provided new insights into how platelet receptors are deployed during the interactions with the vascular subendothelial matrix that lead to haemostatic plug formation. (+info)Bcl-2 regulates amplification of caspase activation by cytochrome c. (3/10855)
Caspases, a family of specific proteases, have central roles in apoptosis [1]. Caspase activation in response to diverse apoptotic stimuli involves the relocalisation of cytochrome c from mitochondria to the cytoplasm where it stimulates the proteolytic processing of caspase precursors. Cytochrome c release is controlled by members of the Bcl-2 family of apoptosis regulators [2] [3]. The anti-apoptotic members Bcl-2 and Bcl-xL may also control caspase activation independently of cytochrome c relocalisation or may inhibit a positive feedback mechanism [4] [5] [6] [7]. Here, we investigate the role of Bcl-2 family proteins in the regulation of caspase activation using a model cell-free system. We found that Bcl-2 and Bcl-xL set a threshold in the amount of cytochrome c required to activate caspases, even in soluble extracts lacking mitochondria. Addition of dATP (which stimulates the procaspase-processing factor Apaf-1 [8] [9]) overcame inhibition of caspase activation by Bcl-2, but did not prevent the control of cytochrome c release from mitochondria by Bcl-2. Cytochrome c release was accelerated by active caspase-3 and this positive feedback was negatively regulated by Bcl-2. These results provide evidence for a mechanism to amplify caspase activation that is suppressed at several distinct steps by Bcl-2, even after cytochrome c is released from mitochondria. (+info)C/EBPalpha regulates generation of C/EBPbeta isoforms through activation of specific proteolytic cleavage. (4/10855)
C/EBPalpha and C/EBPbeta are intronless genes that can produce several N-terminally truncated isoforms through the process of alternative translation initiation at downstream AUG codons. C/EBPbeta has been reported to produce four isoforms: full-length 38-kDa C/EBPbeta, 35-kDa LAP (liver-enriched transcriptional activator protein), 21-kDa LIP (liver-enriched transcriptional inhibitory protein), and a 14-kDa isoform. In this report, we investigated the mechanisms by which C/EBPbeta isoforms are generated in the liver and in cultured cells. Using an in vitro translation system, we found that LIP can be generated by two mechanisms: alternative translation and a novel mechanism-specific proteolytic cleavage of full-length C/EBPbeta. Studies of mice in which the C/EBPalpha gene had been deleted (C/EBPalpha-/-) showed that the regulation of C/EBPbeta proteolysis is dependent on C/EBPalpha. The induction of C/EBPalpha in cultured cells leads to induced cleavage of C/EBPbeta to generate the LIP isoform. We characterized the cleavage activity in mouse liver extracts and found that the proteolytic cleavage activity is specific to prenatal and newborn livers, is sensitive to chymostatin, and is completely abolished in C/EBPalpha-/- animals. The lack of cleavage activity in the livers of C/EBPalpha-/- mice correlates with the decreased levels of LIP in the livers of these animals. Analysis of LIP production during liver regeneration showed that, in this system, the transient induction of LIP is dependent on the third AUG codon and most likely involves translational control. We propose that there are two mechanisms by which C/EBPbeta isoforms might be generated in the liver and in cultured cells: one that is determined by translation and a second that involves C/EBPalpha-dependent, specific proteolytic cleavage of full-length C/EBPbeta. The latter mechanism implicates C/EBPalpha in the regulation of posttranslational generation of the dominant negative C/EBPbeta isoform, LIP. (+info)Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity. (5/10855)
Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respective TCRs, showing that a single saccharide residue can be accommodated in the standard TCR-MHC geometry. The models also reveal a possible molecular basis for the observed cross-reactivity patterns of the CTL clones, which appear to be influenced by the length of the CDR3 loop and the nature of the immunizing ligand. (+info)Role of endothelin in the increased vascular tone of patients with essential hypertension. (6/10855)
We investigated the possible role of endothelin in the increased vasoconstrictor tone of hypertensive patients using antagonists of endothelin receptors. Forearm blood flow (FBF) responses (strain-gauge plethysmography) to intraarterial infusion of blockers of endothelin-A (ETA) (BQ-123) and endothelin-B (ETB) (BQ-788) receptors, separately and in combination, were measured in hypertensive patients and normotensive control subjects. In healthy subjects, BQ-123 alone or in combination with BQ-788 did not significantly modify FBF (P=0.78 and P=0.63, respectively). In hypertensive patients, in contrast, BQ-123 increased FBF by 33+/-7% (P<0.001 versus baseline), and the combination of BQ-123 and BQ-788 resulted in a greater vasodilator response (63+/-12%; P=0.006 versus BQ-123 alone in the same subjects). BQ-788 produced a divergent vasoactive effect in the two groups, with a decrease of FBF (17+/-5%; P=0.004 versus baseline) in control subjects and transient vasodilation (15+/-7% after 20 minutes) in hypertensive patients (P<0.001, hypertensives versus controls). The vasoconstrictor response to endothelin-1 was slightly higher (P=0.04) in hypertensive patients (46+/-4%) than in control subjects (32+/-4%). Our data indicate that patients with essential hypertension have increased vascular endothelin activity, which may be of pathophysiological relevance to their increased vascular tone. In these patients, nonselective ETA and ETB blockade seems to produce a greater vasodilator effect than selective ETA blockade. (+info)99mTc-labeled vasoactive intestinal peptide receptor agonist: functional studies. (7/10855)
Vasoactive intestinal peptide (VIP) is a naturally occurring 28-amino acid peptide with a wide range of biological activities. Recent reports suggest that VIP receptors are expressed on a variety of malignant tumor cells and that the receptor density is higher than for somatostatin. Our aims were to label VIP with 99mTc--a generator-produced, inexpensive radionuclide that possesses ideal characteristics for scintigraphic imaging--and to evaluate 99mTc-VIP for bioactivity and its ability to detect experimental tumors. METHODS: VIP28 was modified at the carboxy terminus by the addition of four amino acids that provided an N4 configuration for a strong chelation of 99mTc. To eliminate steric hindrance, 4-aminobutyric acid (Aba) was used as a spacer. VIP28 was labeled with 1251, which served as a control. Biological activity of the modified VIP28 agonist (TP3654) was examined in vitro using a cell-binding assay and an opossum internal anal sphincter (IAS) smooth muscle relaxivity assay. Tissue distribution studies were performed at 4 and 24 h after injection, and receptor-blocking assays were also performed in nude mice bearing human colorectal cancer LS174T. Blood clearance was examined in normal Sprague-Dawley rats. RESULTS: The yield of 99mTc-TP3654 was quantitative, and the yields of 125I-VIP and 1251-TP3654 were >90%. All in vitro data strongly suggested that the biological activity of 99mTc-TP3654 agonist was equivalent to that of VIP28. As the time after injection increased, radioactivity in all tissues decreased, except in the receptor-enriched tumor (P = 0.84) and in the lungs (P = 0.78). The tumor uptake (0.23 percentage injected dose per gram of tissue [%ID/g]) was several-fold higher than 125I-VIP (0.06 %ID/g) at 24 h after injection in the similar system. In mice treated with unlabeled VIP or TP3654, the uptake of 99mTc-TP3654 decreased in all VIP receptor-rich tissues except the kidneys. The blood clearance was biphasic; the alpha half-time was 5 min and the beta half-time was approximately 120 min. CONCLUSION: VIP28 was modified and successfully labeled with 99mTc. The results of all in vitro examinations indicated that the biological activity of TP3654 was equivalent to that of native VIP28 and tumor binding was receptor specific. (+info)Stimulation of phosphorylase kinase autophosphorylation by peptide analogs of phosphorylase. (8/10855)
Autoactivation of phosphorylase kinase in the presence of substrates has been studied to determine the cause of the hysteresis, or lag, in the phosphorylase kinase reaction. Peptide analogs corresponding to the convertible serine region of phosphorylase have been used as low molecular weight alternative substrates. Autophosphorylation of the kinase molecule was measured under conditions that favored autoactivation. Phosphorylase b and a tetradecapeptide, which was found to be a good model of phosphorylase, stimulated autoactivation by 86- and 37-fold, respectively. The tetradecapeptide also stimulated autophosphorylation of subunits A and B of the kinase molecule. This increased autophosphorylation coincided with an increased ability to convert phosphorylase. This finding supports the hypothesis that autophosphorylation is responsible for the lag in the phosphorylase kinase reaction. No evidence was obtained to suggest that the lag could be due to dissociation of the kinase. The stoichiometry of phosphate incorporation into phosphorylase kinase subunits by autophosphorylation was much greater than that reported to occur by protein kinase phosphorylation. Multiple phosphorylation sites in subunit A accounted for most of the phosphate incorporation during autophosphorylation. Saturating levels of hexa- and octapeptide analogs also caused stimulation of autophosphorylation. Possible mechanisms and experimental implications of substrate-stimulated autophosphorylation are discussed. Consideration also is given to the possible role of effectors in autophosphorylation in vivo. (+info)
In vivo response to growth hormone-releasing peptide-6 in adre...
Trypsin-modulating oostatic factor elisa and antibody
Epidermal growth factor and growth hormone-releasing peptide-6: Combined therapeutic approach in experimental stroke - IOS Press
RGD peptides
Patente US5906975 - Conformationally stabilized cell adhesion peptides - Google Patentes
oppB - Oligopeptide transport system permease protein OppB - Escherichia coli (strain K12) - oppB gene & protein
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Edwards Lab: September 2006
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Oligopeptide
An oligopeptide, often just called peptide (oligo-, "a few"), consists of two to twenty amino acids and can include dipeptides ... Netropsin - A basic oligopeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T ... Antipain - An oligopeptide produced by various bacteria which acts as a protease inhibitor. Ceruletide - A specific decapeptide ... Pepstatins - N-acylated oligopeptides isolated from culture filtrates of Actinomycetes, which act specifically to inhibit acid ...
Renal oligopeptide reabsorption
... is the part of renal physiology that deals with the retrieval of filtered oligopeptides, ... Longer oligopeptides, such as angiotensin and glutathione are degraded by enzymes on the brush border, while shorter ones, such ...
Oligopeptide P11-4
... is a synthetic, pH controlled self-assembling peptide used for biomimetic mineralization e.g. for enamel ... P11-4 (INCI name Oligopeptide 104) consists of the natural occurring amino acids Glutamine, Glutamic acid, Phenylalanine, ... "European Commission database with information on cosmetic substances and ingredients". Oligopeptide 104. Retrieved 1 July 2015 ... Medicine portal Amorphous calcium phosphate Remineralisation of teeth Oligopeptide Biomimetic materials Fluoride Recaldent ...
Oligopeptide-transporting ATPase
... oligopeptide(in) The 3 substrates of this enzyme are ATP, H2O, and oligopeptide, whereas its 3 products are ADP, phosphate, and ... In enzymology, an oligopeptide-transporting ATPase (EC 3.6.3.23) is an enzyme that catalyzes the chemical reaction ATP + H2O + ... The systematic name of this enzyme class is ATP phosphohydrolase (oligopeptide-importing). This enzyme is also called ... of the oligopeptide permease of Salmonella typhimurium". Mol. Microbiol. 6 (1): 47-57. doi:10.1111/j.1365-2958.1992.tb00836.x. ...
Proton-dependent oligopeptide transporter
The proton-dependent oligopeptide transporter (PTR) family of proteins is distinct from the ABC-type peptide transporters and ... As of this edit, this article uses content from "2.A.17 The Proton-dependent Oligopeptide Transporter (POT/PTR) Family", which ... Oligopeptide transporter, peptide:H+ symporter InterPro: IPR004768 Amino acid/peptide transporter InterPro: IPR005279 FP12591; ... Proteins of the Proton-dependent Oligopeptide Transporter (POT) Family (also called the PTR (peptide transport) family) are ...
Oligodendrocyte progenitor cell
Molecular dynamics of oligopeptides. 3. Maps of levels of free energy of modified dipeptides and dynamic correlation in amino ...
Organocatalysis
The cinchona alkaloids, certain oligopeptides. Synthetic catalysts derived from biomolecules. Hydrogen bonding catalysts, ...
Lipoxin
... various N-formyl oligopeptides that, like FMLP, are either released by microbes and mitochondria or are analogs of those ... released by microbes and mitochondria; b) microbe-derived non-formyl oligopeptides; c) certain polypeptides that are associated ...
Eicosanoid receptor
... oligopeptides such as N-Formylmethionine-leucyl-phenylalanine; and various proteins such as the amino acid 1 to 42 fragment of ...
Oligoester
Oligopeptide Fyles, Thomas Murray; Luong, Horace (2009). "Solid-phase synthesis of a library of linear oligoester ion-channels ...
Peptide transporter 1
PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton ... Gonzalez DE, Covitz KM, Sadée W, Mrsny RJ (1998). "An oligopeptide transporter is expressed at high levels in the pancreatic ... Adibi SA (2003). "Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease". Am. J. ... "Entrez Gene: SLC15A1 Solute carrier family 15 (oligopeptide transporter), member 1". Liang R, Fei YJ, Prasad PD, Ramamoorthy S ...
Epitope mapping
Array-based oligo-peptide scanning. Also known as overlapping peptide scan or pepscan analysis, this technique uses a library ... For example, an antibody against CD20 was mapped in a study using array-based oligo-peptide scanning, by combining non-adjacent ... of oligo-peptide sequences from overlapping and non-overlapping segments of a target protein, and tests for their ability to ...
Beta-peptidyl aminopeptidase
... alpha-oligopeptides". The FEBS Journal. 273 (23): 5261-72. doi:10.1111/j.1742-4658.2006.05519.x. PMID 17064315. S2CID 84167461 ... beta-oligopeptides". Chemistry & Biodiversity. 3 (12): 1325-48. doi:10.1002/cbdv.200690136. PMID 17193247. S2CID 38292191. ... "Bacterial beta-peptidyl aminopeptidases with unique substrate specificities for beta-oligopeptides and mixed beta, ...
Spin isomers of hydrogen
"NMR Signal Enhancement by Effective SABRE Labeling of Oligopeptides". Chemistry - A European Journal. 21 (36): 12616-12619. doi ... "Magnetic Resonance Signal Amplification by Reversible Exchange of Selective PyFALGEA Oligopeptide Ligands Towards Epidermal ...
Biomimetic material
One example is oligopeptide P11-4. In dental orthopedics and implants, a more traditional strategy to improve the density of ...
Lycium barbarum
Of particular interest are cyclic oligopeptides with 8 aminoacid rings. The leaves are known to contain the flavonoids ...
Alpha helix
The 3 most popular ways of visualizing the alpha-helical secondary structure of oligopeptide sequences are (1) a helical wheel ... Changes in binding orientation also occur for facially-organized oligopeptides. This pattern is especially common in ... oligopeptides readily adopt stable α-helical structure. Furthermore, crosslinks can be incorporated into peptides to ...
Competence factor
CSF is a five amino acid oligopeptide and is exported via the GSP pathway. CSF enters the cell through oligopeptide permeate ... ComX is a ten amino acid oligopeptide; it requires two co-components, ComP, an histidine kinase, and ComA, a cytoplasmic ...
Ribonucleotide reductase
Cooperman BS (2003). "Oligopeptide inhibition of class I ribonucleotide reductases". Biopolymers. 71 (2): 117-31. doi:10.1002/ ...
Low complexity regions in proteins
Tandem repeats of short oligopeptides that are rich in glycine, proline, serine or threonine are capable of forming flexible ... Thus, these two codons and their respective amino acids must have been constituents of the earliest oligopeptides, with a ... Trifonov, Edward N. (September 2009). "The origin of the genetic code and of the earliest oligopeptides". Research in ... the early genetic code may have also produced low complexity oligo-peptides from valine and leucine. However, later on, within ...
Genetic code
Trifonov, Edward N. (September 2009). "The origin of the genetic code and of the earliest oligopeptides". Research in ...
Pancreatic enzymes (medication)
The trypsin found in pancreatin works to hydrolyze proteins into oligopeptides; amylase hydrolyzes starches into ...
PPIL3
Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to ...
Angiotensin
An oligopeptide, angiotensin is a hormone and a dipsogen. It is derived from the precursor molecule angiotensinogen, a serum ...
Self-assembling peptide
1995). "Self-complementary oligopeptide matrices support mammalian cell attachment". Biomaterials. 16 (18): 1385-1393. doi: ... 1993). "Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane" (PDF). Proc. Natl. ...
Homochirality
Blanco, Celia; Hochberg, David (2012). "Homochiral oligopeptides by chiral amplification: interpretation of experimental data ...
Formyl peptide receptor 2
Many oligopeptides that possess an N-Formylmethionine N-terminal residue such as the prototypical tripeptide N-Formylmethionine ... Early studies suggested that these formyl oligopeptides operated by a Receptor (biochemistry) mechanism. Accordingly, the human ... function by binding any one of a wide variety of ligands including not only certain N-Formylmethionine-containing oligopeptides ... a gene that when transfected into FMLP-unresponsive cells bestowed responsiveness to this and other N-formyl oligopeptides. ...
Oligopeptidase A
This enzyme catalyses the following chemical reaction Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly ...
Autoinducer
Unlike some AHLs, however, most oligopeptides do not act as transcription factors themselves. The free-living bioluminescent ... Gram-positive bacteria that participate in quorum sensing typically use secreted oligopeptides as autoinducers. Peptide ... Whereas Gram-negative bacteria primarily use acylated homoserine lactones, Gram-positive bacteria generally use oligopeptides ...
N-Formylmethionine
Instead, fMet-containing oligopeptides and proteins appear to be released by the mitochondria of damaged tissues as well as by ... fMet-containing oligopeptides and proteins also function in other physiological and pathological responses. Formyl peptide ... The prototypical fMet-containing oligopeptide is N-formylmethionine-leucyl-phenylalanine (FMLP) which activates leukocytes and ... the fMet-containing oligopeptides and proteins are part of the innate immune system; they function to initiate acute ...
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FDA and University of Maryland CERSI Lecture on the Role and Relevance of Proton-Coupled Oligopeptide Transporters in the Brain ... to his newest research on the role and relevance of proton-coupled oligopeptide transporters (PepT2 and PhT1) in this sanctuary ... physiology and pharmacology of proton-coupled oligopeptide transporters. ...
Retracted: Protective Effects of Soy Oligopeptides in Ultraviolet B-Induced Acute Photodamage of Human Skin
B.-r. Zhou, L.-w. Ma, J. Liu et al., "Protective Effects of Soy OligoPeptides in Ultraviolet B-Induced Acute Photodamage of ... Oxidative Medicine and Cellular Longevity has retracted the article titled "Protective Effects of Soy Oligopeptides in ... Retracted: Protective Effects of Soy Oligopeptides in Ultraviolet B-Induced Acute Photodamage of Human Skin. Oxidative Medicine ...
Frontiers | Rational Design of Antiangiogenic Helical Oligopeptides Targeting the Vascular Endothelial Growth Factor Receptors
In this work, helical oligopeptides mimicking the VEGF-C helix were rationally designed based on structural analyses and ... In this work, helical oligopeptides mimicking the VEGF-C helix were rationally designed based on structural analyses and ... For this reason, such Cα,α-disubstituted amino acids constitute suitable building blocks to synthesize oligopeptide with a ... In this work, helical oligopeptides mimicking the VEGF-C helix were rationally designed based on structural analyses and ...
Molecular Recognition between Oligopeptides and Nucleic Acids: Sequence-Specific Binding of the Naturally Occurring Antibiotic ...
Anti-Fatigue Effects of Small Molecule Oligopeptides Isolated from
Ginseng oligopeptides could be a novel natural agent for relieving exercise fatigue. ... Ginseng oligopeptides could be a novel natural agent for relieving exercise fatigue. - GreenMedInfo Summary ... There were more studies on ginsenosides and polysaccharides, but fewer studies on ginseng oligopeptides (GOP), which are small ... Anti-Fatigue Effects of Small Molecule Oligopeptides Isolated from Panax ginseng C. A. Meyer in Mice. ...
Variable domain sequences of mAb with high affinity for a linear oligopeptide - The Jenner Institute
MINIRES: elastomeric oligopeptide | Knowledgeshare
MINIRES is an oligopeptide based on a recurring consensus sequence in resilin, a particular natural elastomeric protein, ... The presence of halogenated atoms does not affect the toxicity of the patented oligopeptides, even at high concentrations but ... The halogenation of at least one oligopeptide residue allows to replicate the elastic properties of the entire resilin, ... The halogenation of at least one oligopeptide residue allows to replicate the elastic properties of the entire resilin, ...
Toxins | Free Full-Text | Morphologic, Phylogenetic and Chemical Characterization of a Brackish Colonial Picocyanobacterium ...
The nonribosomal oligopeptide profile adds another potential identification criterion in future inter- and intraspecies ... Chemical analyses of the strain indicated production of nonribosomal oligopeptides. In fractionated extracts, masses and ion ... The strain was characterized by morphological features, partial 16S rRNA sequence and nonribosomal oligopeptide profile. The ... Nonribosomal Oligopeptides Produced by Strain 06S067. In this study, the production of APs was indicated in an established ...
Illuminating Oligopeptide Mask - Supreme Boutique Spa
SKINCARE- hEGF (rh-Oligopeptide 1) | BioBoost Synbio
Oligopeptide-143 - Surfactant - SAAPedia - Surfactant Technology Platform
Prediction of Efficacy of Oligo-Peptides using QSAR and ANN| Abstract
Serum metabolic effects of corn oligopeptides with 7-day supplementation on early post-surgery primary liver cancer patients: a...
Business Development Manager, Oligo/Peptide Discovery - Oligonucleotide Therapeutics Society
Thermoresponsive micelles from oligopeptide-grafted cyclotriphosphazenes - Fingerprint - Ewha Womans University
Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT)...
Yellow Rose Hyaluronic Beauty Elixir with oligopeptides and flower extracts - 30ml - Doxopoulos Beauty Salons
Αρχική σελίδα / Brands / Yellow Rose / Yellow Rose Hyaluronic Beauty Elixir with oligopeptides and flower extracts - 30ml. ... Αρχική σελίδα / Brands / Yellow Rose / Yellow Rose Hyaluronic Beauty Elixir with oligopeptides and flower extracts - 30ml. ... Yellow Rose Hyaluronic Beauty Elixir with oligopeptides and flower extracts - 30ml ποσότητα. ... Yellow Rose Hyaluronic Face Firming Cream with oligopeptides and flower extracts - 50ml. ...
Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function
In vitro Antioxidant and Antidiabetic Activity of Oligopeptides Derived from Different Mulberry (Morus alba L.) Cultivars |...
Jha S, Gupta SK, Bhattacharyya P, Ghosh A, Mandal P. In vitro Antioxidant and Antidiabetic Activity of Oligopeptides Derived ... Keywords:Antidiabetic, Antioxidant, High‑performance liquid chromatography, Mulberry, Oligopeptide, Ultrafiltration. View:. * ... Home / Pharmacognosy Research, Vol 10, Issue 4, Oct-Dec, 2018 / In vitro Antioxidant and Antidiabetic Activity of Oligopeptides ... Further, the variation in amino acid composition of the oligopeptides could be associated with the observed variation in their ...
Specific Ion Effects on an Oligopeptide: Bidentate binding matters for the Guanidinium Cation :: MPG.PuRe
Specific Ion Effects on an Oligopeptide: Bidentate binding matters for the Guanidinium Cation ... Specific Ion Effects on an Oligopeptide: Bidentate binding matters for the Guanidinium Cation Balos, V., Marekha, B. A., Malm, ... 2019). Specific Ion Effects on an Oligopeptide: Bidentate binding matters for the Guanidinium Cation. Angewandte Chemie ...
EWG Skin Deep® | Glo Skin Beauty Super Serum Rating
The 'appetite-suppressing' effect of proteins | EurekAlert!
Exploring the sequence space for (tri-)peptide self-assembly to design and discover new hydrogels | Nature Chemistry
Membrane Biology
Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1) in vivo |...
Carrier-mediated transport of oligopeptides in the human fibrosarcoma cell line HT1080.. *T. Nakanishi, I. Tamai, Y. Sai, T. ... Antitumor activity of the alkylating oligopeptides J1 (L-melphalanyl-p-L-fluorophenylalanine ethyl ester) and P2 (L-prolyl-m-L- ... Peptichemio (PTC), a mixture of six oligopeptides all containing m-L-sarcolysin, has previously shown impressive results in ... which is similar but not identical to the well-characterized oligopeptide transporters PepT1 and PepT2, exists in fibroblast- ...
Volume 14 Issue 11, November 2022
Genome-wide analysis indicates diverse physiological roles of the turnip (<em>Brassica rapa</em> var. <em>rapa</em>)...
Oligopeptide transporters (OPTs) encode integral membrane-localized pr... ... rapa) oligopeptide transporters gene family Yanan Pua,b,c,d, Danni Yanga,b,c,d, Xin Yina,b,c,d, Qiuli Wanga,b,c,e, Qian Chena,b ... Analyses of the oligopeptide transporter gene family in poplar and grape. BMC Genomics 12, 465.. Cheng, F., Sun, R., Hou, X., ... Evolution of the oligopeptide transporter family. J. Membr. Biol. 240, 89-110.. Gruber, B.D., Giehl, R.F., Friedel, S., von ...
ExtractTransporterProton-coupled oligopeptide transportersPeptidePeptidesTransportersProteinSerumConformationCollagenPhenylalaninePolypeptideProteinsEncodeSyntheticEffectsSkinBrushFamilySmallCookiesExtractPalmitoylEpidermal growthProton-coupledIngredientsOppAPermeaseCotransporterSupramolecular complexesEssenceLysineCreamAmino acid seqChiralSequenceMonoclonalMinimizeIsomerizationRegulatory
Extract1
- Mulberry Extract, Green Tea Extract, and Oligopeptide-51 - an advanced ingredient blend that decreases the production of unwanted pigment to brighten skin and produce a clear, even complexion. (dermapro.com)
Transporter4
- Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT) family. (ox.ac.uk)
- Analyses of the oligopeptide transporter gene family in poplar and grape. (kib.ac.cn)
- The oligopeptide transporter (PepT 1), which is located in the intestinal brush border membrane, provides a major mechanism for protein absorption in the small intestine. (tokushima-u.ac.jp)
- PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. (cdc.gov)
Proton-coupled oligopeptide transporters3
- During his career, he has made many important scientific contributions, including those on the kinetic-dynamic relationship of loop diuretics, the determinants of renal drug elimination, the regional pharmacokinetics of anticancer drugs, and the cellular and molecular biology, physiology and pharmacology of proton-coupled oligopeptide transporters. (fda.gov)
- In this presentation, Dr. Smith gave a general overview of drug transporters in the brain and, more specifically, to his newest research on the role and relevance of proton-coupled oligopeptide transporters (PepT2 and PhT1) in this sanctuary tissue. (fda.gov)
- The proton coupled oligopeptide transporters, PepT1 and PepT2, have been successfully targeted using this approach. (biorxiv.org)
Peptide1
- The halogenation of at least one oligopeptide residue allows to replicate the elastic properties of the entire resilin, enhancing the spontaneous self-assembly of the peptide, without the need to chemical cross-linking. (knowledge-share.eu)
Peptides1
- Hydrolyze contains Palmitoyl peptides (Oligopeptide and Tripeptide 7) , to improve the skin's elasticity. (prweb.com)
Transporters2
- Oligopeptide transporters (OPTs) encode integral membrane-localized proteins and have a broad range of substrate transport capabilities.Here,28 BrrOPT genes were identified in the turnip.Phylogenetic analyses revealed two well-supported clades in the OPT family,containing 15 BrrOPTs and 13 BrrYSLs. (kib.ac.cn)
- rapa ) oligopeptide transporters gene family[J]. Plant Diversity, 2018, 40(02): 57-67. (kib.ac.cn)
Protein3
- MINIRES is an oligopeptide based on a recurring consensus sequence in resilin, a particular natural elastomeric protein, constituting the elastic structures in insects. (knowledge-share.eu)
- The 0.5-3 kDa ranged oligopeptides were isolated using cation exchange chromatography and ultrafiltration system and further characterized by high‑performance liquid chromatography and protein sequencer. (phcogres.com)
- Det unike serumet benytter en plantebasert kopi av EGF (et naturlig forekommende humant protein) og reduserer effektivt synligheten av fine linjer, rynker og porer samtidig som det gir økt glød. (lookfantastic.com)
Serum1
- Gjenoppdag hudens ungdommelige glød med BIOEFFECT EGF Serum , en banebrytende behandling som motvirker aldringstegn og gir synlige og betydelige resultater. (lookfantastic.com)
Conformation1
- Numerous disulfide bonds determine a specific oligopeptide or polypeptide conformation for each toxin to better fit the target. (medscape.com)
Collagen1
- Collagen oligopeptides (ligands) attach to fibroblasts (bone formation cells) receptors on the fibroblast membrane synthesizing new collagen production (1,2,3). (eatyournutrition.com)
Phenylalanine1
- Self-assembly of phenylalanine oligopeptides: insights from experiments and simulations. (nature.com)
Polypeptide1
- A polypeptide composed of L-lysine and L-arginine oligopeptides. (zelens.com)
Proteins1
- Terminal digestion of oligopeptides and disaccharides before absorption is performed by brush border enzymes, either at the surface of the enterocyte in association with transport proteins for their specific products or when released into the intestinal lumen through cleavage by pancreatic peptidases or enzymes freed from exfoliated senescent enterocytes. (msdvetmanual.com)
Encode1
- Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity. (mpg.de)
Synthetic1
- The synthetic modified oligopeptides, available in quantity, served both as immunogens and as chemical standards for quantitative ELISA. (cdc.gov)
Effects3
- Oxidative Medicine and Cellular Longevity has retracted the article titled "Protective Effects of Soy Oligopeptides in Ultraviolet B-Induced Acute Photodamage of Human Skin" [ 1 ]. (hindawi.com)
- Protective Effects of Soy OligoPeptides in Ultraviolet B-Induced Acute Photodamage of Human Skin," Oxidative Medicine and Cellular Longevity , vol. 2016, Article ID 5846865, 13 pages, 2016. (hindawi.com)
- Anti-Fatigue Effects of Small Molecule Oligopeptides Isolated from Panax ginseng C. A. Meyer in Mice. (greenmedinfo.com)
Skin1
- Oligopeptide-1 has well-established wound healing and skin renewal properties. (bioboostsynbio.com)
Brush1
- en børste/brush til at forfine hudtonen. (copenhagentan.dk)
Family1
- Endothelins are a family of 21-amino acid oligopeptides, called endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin 3 (ET-3). (istun.edu.tr)
Small1
- There were more studies on ginsenosides and polysaccharides, but fewer studies on ginseng oligopeptides (GOP), which are small molecule oligopeptides isolated from ginseng. (greenmedinfo.com)
Cookies3
- Al hacer clic en "aceptar todas", acepta el uso de TODAS las cookies. (dermalogica.es)
- De estas, las cookies que se clasifican como necesarias se almacenan en su navegador, ya que son esenciales para el funcionamiento de las funcionalidades básicas del sitio web. (dermalogica.es)
- Estas cookies se almacenarán en su navegador solo con su consentimiento. (dermalogica.es)
Extract1
- De Grown Alchemist Regenerating Night Cream Neuro-Peptide & Violet Leaf Extract is een voedende, hydraterende collageencrème die de strijd tegen rimpels, ouderdomsvlekjes en een verouderde huid aangaat terwijl jij ligt te slapen. (boozyshop.nl)
Palmitoyl3
- Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide-7 work in synergy to help restore and maintain your skin's youthful appearance. (marykay.com)
- Triple Peptide Complex: Palmitoyl oligopeptides, argireline, and vitamin C polypeptides smooth the look of skin, reducing the appearance of deep lines and dark circles. (sephora.com)
- In this formula, it aids the skin in benefitting from the water-binding effects of hyaluronic acid and the smoothing and anti-aging effects of palmitoyl oligopeptide. (imageskincare.com)
Epidermal growth1
- Oligopeptide-1 has an identical chemical structure to an epidermal growth factor and has been shown to increase the rate of healing and renewal of the skin, as well as slow the thinning of aging skin, thus minimizing wrinkles. (arielbiotech.com)
Proton-coupled2
- A new family of β-lactam transporting proton coupled oligopeptide transporters has been cloned from mammalian epithelial cells of kidney, 8- 10 brain, 11 and intestine 12- 15 in the past years. (bmj.com)
- Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. (drugbank.com)
Ingredients2
- Featuring super ingredients Oligopeptide-1, Oligopeptide-5, and Oligopeptide-10, the marine revival essence is the epitome of regenerating power. (haach.com)
- I just cannot recommend a $110 serum that only features HA, proprietary EGF, oligopeptide-1, and two Saccharomyces based ingredients. (skinsciencebymira.com)
OppA1
- Immune response to oligopeptide permease A (OppA) protein in pigs naturally and experimentally infected with Haemophilus parasuis . (iastate.edu)
Permease1
- The spo0K locus of Bacillus subtilis is homologous to the oligopeptide permease locus and is required for sporulation and competence. (wikidata.org)
Cotransporter1
- Proton oligopeptide cotransporter. (nih.gov)
Supramolecular complexes3
- Multiple charge-separation sites have successfully been constructed using supramolecular complexes of multiporphyrinic oligopeptides [P(ZnP) n , n = 2, 4, 8] with fulleropyrrolidine bearing a pyridine or imidazole coordinating ligand , which are organized by utilizing π-π interaction in addition to the coordination bond. (rsc.org)
- In the first example, supramolecular complexes are formed between flexible zinc porphyrinic oligopeptides and fulleropyrrolidine bearing either a pyridine or imidazole functionalized C60 via a coordination bond plus π-π interactions. (wichita.edu)
- The charge separation (CS) lifetimes of the supramolecular oligopeptide complexes have been elongated by increasing the generation of the porphyrins, enabling us to attain the longest lifetime (0.84 ms) for the P(ZnP)8-ImC60 supramolecular system in PhCN solution at 298 K, ever reported for supramolecular complexes. (wichita.edu)
Essence4
- Brace yourselves for the new age of regeneration with DR HAACH Oligopeptides Marine Revival Essence! (haach.com)
- Dr HAACH Oligopeptides Marine Revival Essence is gentle on skin, suitable for sensitive skin. (haach.com)
- Apply Oligopeptides Marine Revival Essence in the morning and evening, after Dr HAACH Cleanser and MicroTreatment Lotion. (haach.com)
- Dispense 5 to 6 drops of Oligopeptides Marine Revival Essence on your palm or on a cotton pad. (haach.com)
Lysine1
- The last ingredient is glycyl-alanyl-lysine-l-glutamine in the form of Oligopeptide-Enzymatic Technology . (supplementcritic.com)
Cream1
- Mindful that chronic hydroquinone use can cause ochronosis (permanent darkening), she has patients alternate with a nonhydroquinone bleaching agent such as lignin peroxidase, oligopeptide, Lytera, Melaplex, 4-n-butylresorcinol, Cysteamine cream, tranexamic acid, or oral antioxidants. (medscape.com)
Amino acid seq1
- This vector can be conveniently used to construct libraries of oligopeptides with a random amino acid sequence. (nih.gov)
Chiral3
- A possible role that might have been played by ordered clusters at interfaces for the generation of homochiral oligopeptides under prebiotic conditions has been probed by a catalyzed polymerization of amphiphilic activated a-amino acids, in racemic and chiral non-racemic forms, which had self-assembled into two-dimensional (2D) ordered crystallites at the air-aqueous solution interface. (dtu.dk)
- An efficient chiral amplification was obtained in the polymerization of nonracemic mixtures of C-18-Glu-NCA since the monomer molecules in the racemic 2D crystallites are oriented such that the reaction occurs between heterochiral molecules related by glide symmetry to yield heterochiral oligopeptides whereas the enantiomer in excess, in the enantiomorphous crystallites, yield oligopeptides of a single handedness. (dtu.dk)
- Split of chiral degeneracy in mechanical and structural properties of oligopeptide-polysaccharide biomaterials. (academictree.org)
Sequence1
- The experimental relative abundance of oligopeptides with homochiral sequence generated from (R,S)-C-18-TE-Lys and (R,S)-C-18-TE-Glu, as determined by mass spectrometry on enantioselectively deuterium-labeled samples, was found to be significantly larger than that obtained from (R,S) C-18-thio-Glu which polymerizes randomly. (dtu.dk)
Monoclonal1
- An antipeptide monoclonal antibody was used to affinity-purify phagemids exposing oligopeptides which can interact with the monoclonal antibody. (nih.gov)
Minimize2
- A series of monocationic lexitropsins, or information-reading oligopeptides, were synthesized to minimize and offset the AT bias for doubly cationic ligands bound in the minor groove of DNA. (syr.edu)
- Bumps: Renewing oligopeptides help minimize the look of bumpiness. (target.com)
Isomerization2
- It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (uniprot.org)
- Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. (nih.gov)
Regulatory1
- Endogenous regulatory oligopeptide database. (receptors.org)