Hirsutism
Polycystic Ovary Syndrome
Variation of luteinizing hormone and androgens in oligomenorrhoea and its implications for the study of polycystic ovary syndrome. (1/64)
We measured luteinizing hormone (LH) and androgen concentrations in patients at different phases of the oligomenorrhoeic cycle and compared the results with those of patients with normogonadotrophic amenorrhoea. Several blood samples separated by >/=7 days were obtained from each of 72 patients with oligomenorrhoea and 18 with normogonadotrophic amenorrhoea. The oligomenorrhoeic cycle was divided into five phases: the postmenstrual phase week 1 (day 1-7) and week 2 (day 8-14), the specific oligomenorrhoeic phase (SOP, day 15 after a menstruation to day 21 before the next menstruation), the possibly peri-ovulatory phase (days 21-11 before menstruation) and the premenstrual phase (days 10-1 before menstruation). Samples obtained in the possibly peri-ovulatory phase were excluded. Within individuals LH concentrations were significantly higher during the SOP than during all other phases of the oligomenorrhoeic cycle (paired t-test, P = 0.0001-0.03). In contrast to the other phases of the oligomenorrhoeic cycle, no significant differences in gonadotrophins, androgen or oestradiol concentrations were found between the SOP and normogonadotrophic amenorrhoea. In oligomenorrhoea timing of blood sampling influences the measurement of LH and androgen concentrations, and the accurate interpretation of these measurements requires that the dates of menstruation both before and after the sample is taken should be known. In patients with oligomenorrhoea blood samples should be obtained during the SOP, when the endocrinology is comparable with that of normogonadotrophic amenorrhoea. (+info)Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. (2/64)
Polycystic ovary syndrome (PCOS) is a common endocrine disorder of women, characterized by hyperandrogenism and chronic anovulation. It is a leading cause of female infertility and is associated with polycystic ovaries, hirsutism, obesity, and insulin resistance. We tested a carefully chosen collection of 37 candidate genes for linkage and association with PCOS or hyperandrogenemia in data from 150 families. The strongest evidence for linkage was with the follistatin gene, for which affected sisters showed increased identity by descent (72%; chi(2) = 12.97; nominal P = 3.2 x 10(-4)). After correction for multiple testing (33 tests), the follistatin findings were still highly significant (P(c) = 0.01). Although the linkage results for CYP11A were also nominally significant (P = 0.02), they were no longer significant after correction. In 11 candidate gene regions, at least one allele showed nominally significant evidence for population association with PCOS in the transmission/disequilibrium test (chi(2) >/= 3.84; nominal P < 0.05). The strongest effect in the transmission/disequilibrium test was observed in the INSR region (D19S884; allele 5; chi(2) = 8.53) but was not significant after correction. Our study shows how a systematic screen of candidate genes can provide strong evidence for genetic linkage in complex diseases and can identify those genes that should have high (or low) priority for further study. (+info)Endocrine features of polycystic ovary syndrome in a random population sample of 14-16 year old adolescents. (3/64)
Hospital based studies have shown that oligomenorrhoeic adolescents have high luteinizing hormone (LH) and androgen concentrations, endocrine signs of polycystic ovary syndrome (PCOS). The prevalence of these abnormalities in an unselected population of adolescents is not known. We determined LH, follicle stimulating hormone (FSH), androstenedione, testosterone, dehydroepiandrosterone sulphate (DHEAS), oestradiol and prolactin concentrations in unselected population samples of adolescents with oligomenorrhoea, secondary amenorrhoea and regular menstrual cycles. A total of 2248 white, west European adolescents, aged 15.3 +/- 0.6 (mean +/- SD) years, participated. Blood was taken from 107 adolescents with regular menstrual cycles, 52 with oligomenorrhoea and four with secondary amenorrhoea. Oligomenorrhoeic adolescents had higher mean LH, androstenedione, testosterone, DHEAS and oestradiol concentrations compared with girls with regular menstrual cycles; 57% of the oligomenorrhoeic girls had LH or androgen concentrations above the 95th centile of adolescents with regular menstrual cycles. None of the 52 oligomenorrhoeic girls and only one of four girls with secondary amenorrhoea had a hypogonadotrophic endocrine pattern. The present study and available literature support the view that oligomenorrhoea in adolescents is not a stage in the physiological maturation of the hypothalamic pituitary-ovarian axis but an early sign of PCOS associated with subfertility. Physicians should consider endocrine evaluation before reassuring oligomenorrhoeic girls or prescribing oral contraceptives to these girls. (+info)Effects of the insulin sensitizing drug metformin on ovarian function, follicular growth and ovulation rate in obese women with oligomenorrhoea. (4/64)
Hyperinsulinaemic insulin resistance is commonly associated with hyperandrogenaemia, and menstrual dysfunction. The aim of this study was to examine the effects of the insulin sensitizing drug, metformin, on ovarian function, follicular growth, and ovulation rate in obese women with oligomenorrhoea. Twenty obese subjects with oligomenorrhoea [polycystic ovarian syndrome; (PCOS)] were observed longitudinally for 3 weeks prior to and for 8 weeks during treatment with metformin (850 mg twice per day). Fifteen patients completed the study. The frequency of ovulation was significantly higher during treatment than before treatment (P = 0.003). A significant decline in both testosterone and luteinizing hormone concentrations was recorded within 1 week of commencing treatment. Patients with elevated pretreatment testosterone concentrations showed the most marked increase in ovulation rate (P < 0.005), and significant reductions in circulating testosterone from 1.02 to 0.54 ng/ml (P < 0.005) after only 1 week of treatment. However, the sub-group with raised fasting insulin showed less marked changes, and the sub-group with normal testosterone concentrations showed no effect of treatment. Metformin had a rapid effect upon the abnormal ovarian function in hyperandrogenic women with PCOS, correcting the disordered ovarian steroid metabolism and ovulation rate; however, there appeared to be no effect in cases where the circulating androgen concentration was normal. (+info)Women with polycystic ovary syndrome gain regular menstrual cycles when ageing. (5/64)
The aim of this study was to investigate if previously oligo- or amenorrhoeic polycystic ovary syndrome (PCOS) patients gain regular menstrual cycles when ageing. Women registered as having PCOS, based on the combination of oligo- or amenorrhoea and an increased LH concentration, were invited by letter to participate in a questionnaire by telephone. In this questionnaire we asked for the prevalent menstrual cycle pattern, which we scored in regular cycles (persistently shorter than 6 weeks) or irregular cycles (longer than 6 weeks). We interviewed 346 patients of 30 years and older, and excluded 141 from analysis mainly because of the use of oral contraceptives. The remaining 205 patients showed a highly significant linear trend (P < 0.001) for a shorter menstrual cycle length with increasing age. Logistic regression analysis for body mass index, weight loss, hirsutism, previous treatment with clomiphene citrate or gonadotrophins, previous pregnancy, ethnic origin and smoking showed no influence on the effect of age on the regularity of the menstrual cycle. We conclude that the development of a new balance in the polycystic ovary, solely caused by follicle loss through the process of ovarian ageing, can explain the occurrence of regular cycles in older patients with PCOS. (+info)Clinical presentation of PCOS following development of an insulinoma: case report. (6/64)
A 24 year old woman presented with a prolonged clinical history of fasting and exertional hypoglycaemia, and was subsequently diagnosed with an insulinoma. Concurrent symptoms of oligomenorrhoea and hyperandrogenism of similar duration were noted. Biochemically, hyperinsulinaemia was observed in association with a raised serum luteinizing hormone (LH), raised testosterone and androstendione concentrations. Surgical removal of the insulinoma resulted in resolution of the clinical and biochemical features of the polycystic ovarian syndrome (PCOS) but minimal change was observed in the ovarian ultrasound appearances. This case demonstrates the role of insulin in mediating the hypersecretion of both LH and androgens in women with polycystic ovaries. We suggest that hyperinsulinaemia converted occult 'polycystic ovaries' to become clinically manifest as 'polycystic ovary syndrome'. This paradigm has clear implications for women with insulin dependent diabetes mellitus who presumably have systemic hyperinsulinaemia. (+info)Are synchronised swimmers at risk of amenorrhoea? (7/64)
OBJECTIVE: Synchronised swimming is a sport that shares certain characteristics with other aesthetically pleasing sports such as gymnastics and dance. The purpose of this investigation was to ascertain whether the highest ranked synchronised swimmers in the United Kingdom experience menstrual abnormalities, a common medical problem seen in these related activities. METHODS: Twenty three members of the Great Britain synchronised swimming squad completed a questionnaire on menstrual history. Body composition and VO(2)MAX were measured in the laboratory during regular physiological screening. RESULTS: Three of the 23 subjects were oligomenorrhoeic and none were amenorrhoeic. All were postmenarchal. Mean estimated body fat percentage was 23%, and mean VO(2)MAX was 47.2 ml/kg/min. CONCLUSIONS: It appears that synchronised swimmers in the United Kingdom are relatively protected from menstrual disturbances for reasons that cannot be explained in isolation. (+info)Studies on the metabolic clearance rate and production rate of human luteinizing hormone and on the initial half-time of its subunits in man. (8/64)
The metabolic clearance rate (MCR) of human luteinizing hormone (hLH) has been determined in 10 normal men, 3 normal women, and in 12 women with ovulatory disorders resulting in oligomenorrhea or amenorrhea. The MCR was determined by the constant infusion technique using either iodinated or unlabeled highly purified hLH, and these results were compared to MCR determined by using crude pituitary preparations containing both follicle-stimulating hormone and hLH. Both preparations produced essentially similar results for the MCR of hLH and virtually identical results were obtained when complete or incomplete immunoprecipitation of the infused material was achieved. The MCR/body surface area of hLH was significantly greater in normal men (25.6 plus or minus 3.6 ml/min-m-2) than in normal premenopausal (19.2 plus or minus 0.9 ml/min-m-2) or postmenopausal women (17.4 plus or minus 1.9 ml/min-m-2). No difference was noted in the MCR of hLH in women with oligomenorrhea or amenorrhea. Production rates (PRs) were calculated by using a pituitary standard, the values being 85.1 plus or minus 21.5 IU/24 h in normal men, 39.9 plus or minus 12.6 IU/24 h in normal premenopausal women, and 294.6 plus or minus 61.9 IU/24 h in normal postmenopausal women. The initial half-times of disappearance of the alpha- and beta-subunits of hLH were measured in two normal men and found to be 15-18 min, respectively. The half-time of intact hLH was twice as great. (+info)Oligomenorrhea is a medical term used to describe infrequent menstrual periods, where the cycle length is more than 35 days but less than 68 days. It's considered a menstrual disorder and can affect people of reproductive age. The causes of oligomenorrhea are varied, including hormonal imbalances, polycystic ovary syndrome (PCOS), thyroid disorders, excessive exercise, significant weight loss or gain, and stress. In some cases, it may not cause any other symptoms, but in others, it can be associated with infertility, hirsutism (excessive hair growth), acne, or obesity. Treatment depends on the underlying cause and may include lifestyle modifications, hormonal medications, or surgery in rare cases.
Menstruation disturbances, also known as menstrual disorders, refer to any irregularities or abnormalities in a woman's menstrual cycle. These disturbances can manifest in various ways, including:
1. Amenorrhea: The absence of menstrual periods for three consecutive cycles or more in women of reproductive age.
2. Oligomenorrhea: Infrequent or light menstrual periods that occur at intervals greater than 35 days.
3. Dysmenorrhea: Painful menstruation, often accompanied by cramping, pelvic pain, and other symptoms that can interfere with daily activities.
4. Menorrhagia: Heavy or prolonged menstrual periods that last longer than seven days or result in excessive blood loss, leading to anemia or other health complications.
5. Polymenorrhea: Abnormally frequent menstrual periods that occur at intervals of 21 days or less.
6. Metrorrhagia: Irregular and unpredictable vaginal bleeding between expected menstrual periods, which can be caused by various factors such as hormonal imbalances, infections, or structural abnormalities.
Menstruation disturbances can have significant impacts on a woman's quality of life, fertility, and overall health. They may result from various underlying conditions, including hormonal imbalances, polycystic ovary syndrome (PCOS), thyroid disorders, uterine fibroids, endometriosis, or sexually transmitted infections. Proper diagnosis and treatment of the underlying cause are essential for managing menstruation disturbances effectively.
Amenorrhea is a medical condition characterized by the absence or cessation of menstrual periods in women of reproductive age. It can be categorized as primary amenorrhea, when a woman who has not yet had her first period at the expected age (usually around 16 years old), or secondary amenorrhea, when a woman who has previously had regular periods stops getting them for six months or more.
There are various causes of amenorrhea, including hormonal imbalances, pregnancy, breastfeeding, menopause, extreme weight loss or gain, eating disorders, intense exercise, stress, chronic illness, tumors, and certain medications or medical treatments. In some cases, amenorrhea may indicate an underlying medical condition that requires further evaluation and treatment.
Amenorrhea can have significant impacts on a woman's health and quality of life, including infertility, bone loss, and emotional distress. Therefore, it is essential to consult with a healthcare provider if you experience amenorrhea or missed periods to determine the underlying cause and develop an appropriate treatment plan.
Hirsutism is a medical condition characterized by excessive hair growth in women in areas where hair growth is typically androgen-dependent, such as the face, chest, lower abdomen, and inner thighs. This hair growth is often thick, dark, and coarse, resembling male-pattern hair growth. Hirsutism can be caused by various factors, including hormonal imbalances, certain medications, and genetic conditions. It's essential to consult a healthcare professional if you experience excessive or unwanted hair growth to determine the underlying cause and develop an appropriate treatment plan.
Polycyctic Ovary Syndrome (PCOS) is a complex endocrine-metabolic disorder characterized by the presence of hyperandrogenism (excess male hormones), ovulatory dysfunction, and polycystic ovaries. The Rotterdam criteria are commonly used for diagnosis, which require at least two of the following three features:
1. Oligo- or anovulation (irregular menstrual cycles)
2. Clinical and/or biochemical signs of hyperandrogenism (e.g., hirsutism, acne, or high levels of androgens in the blood)
3. Polycystic ovaries on ultrasound examination (presence of 12 or more follicles measuring 2-9 mm in diameter, or increased ovarian volume >10 mL)
The exact cause of PCOS remains unclear, but it is believed to involve a combination of genetic and environmental factors. Insulin resistance and obesity are common findings in women with PCOS, which can contribute to the development of metabolic complications such as type 2 diabetes, dyslipidemia, and cardiovascular disease.
Management of PCOS typically involves a multidisciplinary approach that includes lifestyle modifications (diet, exercise, weight loss), medications to regulate menstrual cycles and reduce hyperandrogenism (e.g., oral contraceptives, metformin, anti-androgens), and fertility treatments if desired. Regular monitoring of metabolic parameters and long-term follow-up are essential for optimal management and prevention of complications.
Oligomenorrhea
Irregular menstruation
Leydig cell tumour
Amenorrhea
Menstruation
Hyperprolactinaemia
Cortisone reductase deficiency
Hypothalamic-pituitary-gonadal axis
Congenital adrenal hyperplasia
Sheehan's syndrome
Menstrual disorder
Late onset congenital adrenal hyperplasia
Gestrinone
Anovulatory cycle
Cabergoline
Polymenorrhea
Ovulation
Metformin
Human nutrition
Hyperprolactinemic SAHA syndrome
Estrogen (medication)
Rose Frisch
Emmenagogue
Oligoamenorrhea
Anabolic steroid
Cushing's syndrome
Estrogen-dependent condition
Anovulation
Polycystic ovary syndrome
Irregular bleeding
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AMENORRHEA OR OLIGOMENORRHEA2
- Diagnosis involves confirmation of 4-6 months of amenorrhea or oligomenorrhea and two measurements of elevated follicle-stimulating hormone (FSH). (medscape.com)
- [1] Women often present with amenorrhea or oligomenorrhea, hirsutism with acne and male-pattern hair growth, weight gain, and difficulty with fertility. (va.gov)
Hirsutism2
- A 32-year-old woman with a history of prolactin excess and pituitary lesion presented with oligomenorrhea, weight gain, facial fullness, and hirsutism. (thejns.org)
- In a randomized trial of 36 adolescent girls who were not sexually active who had polycystic ovary syndrome - characterized by hirsutism and oligomenorrhea - a three-drug combination of low-dose spironolactone , pioglitazone , and metformin (SPIOMET) improved ovulation rates more effectively than did the standard oral contraceptive ethinylestradiol-levonorgestrel treatment. (medscape.com)
Polymenorrhea1
- Thyrotoxicosis is associated mainly with hypomenorrhea and polymenorrhea, whereas hypothyroidism is associated mainly with oligomenorrhea. (nih.gov)
Periods6
- People with PCOS show menstrual irregularities that range from oligomenorrhea and amenorrhea, to very heavy, irregular periods. (wikipedia.org)
- Oligomenorrhea is the condition where the woman suffers from irregular periods. (releasewire.com)
- Oligomenorrhea is a menstrual disorder characterized by inconsistent or irregular blood flow during menstrual periods. (monishamantra.com)
- Oligomenorrhea occurs when the menstrual cycle is of more than 35 days, resulting in just 4 to 9 periods annually. (monishamantra.com)
- Gynecure capsule is one of the best herbal oligomenorrhea supplements to cure painful periods. (sooperarticles.com)
- Not eating enough calories can cause menstrual periods to become irregular ( oligomenorrhea ) or stop ( amenorrhea ). (healthychildren.org)
Menstrual disorders1
- Although menstrual disorders are most strongly associated with anorexia nervosa, bulimia nervosa may also result in oligomenorrhea or amenorrhea. (wikipedia.org)
Disorders2
- Eating disorders can result in oligomenorrhea. (wikipedia.org)
- Amenorrhea, oligomenorrhea, and hyperandrogenic disorders. (medlineplus.gov)
Frequency1
- We concluded that exposure to organic solvents is associated with a trend toward increased frequency of oligomenorrhea. (cdc.gov)
Polycystic1
- People with polycystic ovary syndrome (PCOS) are also likely to have oligomenorrhea. (wikipedia.org)
Menstruation1
- Oligomenorrhea is infrequent (or, in occasional usage, very light) menstruation. (wikipedia.org)
Condition1
- One such condition is Oligomenorrhea, which affects millions of women globally. (uphtr.com)
Women1
- As a result, many women suffer from oligomenorrhea or amenorrhea. (sharedjourney.com)
Year1
- This graph shows the total number of publications written about "Oligomenorrhea" by people in this website by year, and whether "Oligomenorrhea" was a major or minor topic of these publications. (wakehealth.edu)
Result1
- Oligomenorrhea can be a result of prolactinomas (adenomas of the anterior pituitary). (wikipedia.org)
People1
- Below are the most recent publications written about "Oligomenorrhea" by people in Profiles. (wakehealth.edu)
Medicine1
- oligomenorrhea This dictionary is citing Gale Encyclopedia of Medicine. (wikipedia.org)
Amenorrhea9
- People with PCOS show menstrual irregularities that range from oligomenorrhea and amenorrhea, to very heavy, irregular periods. (wikipedia.org)
- Although menstrual disorders are most strongly associated with anorexia nervosa, bulimia nervosa may also result in oligomenorrhea or amenorrhea. (wikipedia.org)
- Amenorrhea, oligomenorrhea, and hyperandrogenic disorders. (medlineplus.gov)
- The physiological underpinnings of amenorrhea/oligomenorrhea (AO) among exercising women are complex and incompletely understood. (stmarys.ac.uk)
- Stein and Leventhal were the first to recognize an association between the presence of polycystic ovaries and signs of hirsutism and amenorrhea (eg, oligomenorrhea, obesity ). (medscape.com)
- Not eating enough calories can cause menstrual periods to become irregular ( oligomenorrhea ) or stop ( amenorrhea ). (healthychildren.org)
- Ovulation disorders are estimated to account for one-third of infertility cases, and they often present with irregular periods (oligomenorrhea) or the absence of periods (amenorrhea). (health.mil)
- A recent randomized controlled trial has shown estrogen replacement to improve verbal memory and executive control in athletes with menstrual dysfunction oligomenorrhea amenorrhea, Baskaran et al 2017. (jewishledger.com)
- Finally, menstrual irregularities such as amenorrhea and oligomenorrhea are common experiences among women with PCOS [ 12 ]. (biomedcentral.com)
Hirsutism2
- Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study. (nature.com)
- Other ovulation issues that seriously impact your fertility include: anovulation, oligomenorrhea and hirsutism. (sharedjourney.com)
Infrequent2
- Oligomenorrhea is infrequent (or, in occasional usage, very light) menstruation. (wikipedia.org)
- In oligomenorrhea (infrequent menses) the interval is greater than 37 days but less than 90. (missmalini.com)
Menstrual cycle2
- Main outcome measures were: prevalence of oligomenorrhea, polymenorrhea, menstrual cycle irregularity, abnormal bleeding length and dysmenorrhea. (unboundmedicine.com)
- The multivariate analysis suggests that the higher prevalence of oligomenorrhea and menstrual cycle irregularity among the girls who were older at menarche might be purely explained by their younger gynecological age. (unboundmedicine.com)
Anovulation1
- These features include oligomenorrhea or anovulation, clinical or biochemical hyperandrogenism and polycystic ovaries. (ukessays.com)
PCOS1
- People with polycystic ovary syndrome (PCOS) are also likely to have oligomenorrhea. (wikipedia.org)
Bulimia1
- Bulimia nervosa typically presents with menstrual irregularities and oligomenorrhea. (medscape.com)