A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
Formation or presence of a blood clot (THROMBUS) in a blood vessel within the SKULL. Intracranial thrombosis can lead to thrombotic occlusions and BRAIN INFARCTION. The majority of the thrombotic occlusions are associated with ATHEROSCLEROSIS.
The formation or presence of a blood clot (THROMBUS) within a vein.
Veins draining the cerebrum.
The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.
Formation or presence of a blood clot (THROMBUS) in the CRANIAL SINUSES, large endothelium-lined venous channels situated within the SKULL. Intracranial sinuses, also called cranial venous sinuses, include the superior sagittal, cavernous, lateral, petrous sinuses, and many others. Cranial sinus thrombosis can lead to severe HEADACHE; SEIZURE; and other neurological defects.
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
A broad-spectrum antimicrobial carboxyfluoroquinoline.
A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A broad-spectrum 6-fluoronaphthyridinone antibacterial agent that is structurally related to NALIDIXIC ACID.
A spectrum of inflammation involving the female upper genital tract and the supporting tissues. It is usually caused by an ascending infection of organisms from the endocervix. Infection may be confined to the uterus (ENDOMETRITIS), the FALLOPIAN TUBES; (SALPINGITIS); the ovaries (OOPHORITIS), the supporting ligaments (PARAMETRITIS), or may involve several of the above uterine appendages. Such inflammation can lead to functional impairment and infertility.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.
Substances that reduce the growth or reproduction of BACTERIA.
Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.
Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.
The interactions between physician and patient.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Use of plants or herbs to treat diseases or to alleviate pain.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
Semisynthetic broad-spectrum cephalosporin.
A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.
Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.
A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.
A non-medical term defined by the lay public as a food that has little or no preservatives, which has not undergone major processing, enrichment or refinement and which may be grown without pesticides. (from Segen, The Dictionary of Modern Medicine, 1992)
The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.
A drugless system of therapy, making use of physical forces such as air, light, water, heat, massage. Treatments are often diet- and nutrition-oriented with attention given to the patient's personal history and lifestyle. (From Cassileth, Alternative Medicine Handbook, 1998, p329)
Liquid components of living organisms.
The giving of drugs, chemicals, or other substances by mouth.
Visible accumulations of fluid within or beneath the epidermis.
The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.
The L-isomer of Ofloxacin.

Comparison of efficacies of oral levofloxacin and oral ciprofloxacin in a rabbit model of a staphylococcal abscess. (1/1104)

Oral levofloxacin was compared to oral ciprofloxacin in a Staphylococcus aureus subcutaneous abscess model in rabbits. Rabbits were surgically prepared with subcutaneous wiffle balls (43 mm in diameter) and allowed to recover for 4 to 6 weeks. Rabbits were infected by direct injection into the capsule with S. aureus ATCC 29213 (5 x 10(5) CFU) and were allowed to remain infected for 8 days before the initiation of anti-infective treatment. Efficacy was determined by assessing the bacterial load within the capsule over a 10-day treatment period. In single-dose pharmacokinetic studies in infected rabbits, similar area under the concentration-time curve/MIC ratios were obtained in the plasma and abscess fluid for levofloxacin at 45 mg/kg of body weight and ciprofloxacin at 200 mg/kg of body weight. Similar efficacies were seen with levofloxacin at 45 mg/kg/day and ciprofloxacin 400 mg/kg/day by day 10. In this model, levofloxacin was significantly more efficacious than ciprofloxacin (P < 0.01).  (+info)

Pharmacodynamic comparisons of levofloxacin, ciprofloxacin, and ampicillin against Streptococcus pneumoniae in an in vitro model of infection. (2/1104)

The increasing frequency of penicillin-resistant pneumococcus continues to be of concern throughout the world. Newer fluoroquinolone antibiotics, such as levofloxacin, have shown enhanced in vitro activity against Streptococcus pneumoniae. In this study, the bactericidal characteristics and pharmacodynamic profiles of levofloxacin, ciprofloxacin, and ampicillin against four isolates of S. pneumoniae were compared by using an in vitro model of infection. Standard antibiotic dosing regimens which simulated the pharmacokinetic profile observed in humans were used. Control and treatment models were sampled for bacterial CFU per milliliter over the duration of each 24- or 48-h experiment. In addition, treatment models were sampled for MIC determinations and drug concentration. Regrowth of all isolates as well as an increase in MICs throughout the study period was observed in the ciprofloxacin experiments. A limited amount of regrowth was noted during levofloxacin therapy for one isolate; however, no change in MIC was detected for any isolate. Ampicillin showed rapid and sustained bactericidal activity against all isolates. In this study, ratios of effective fluoroquinolone area under the concentration-time curve (AUC):MIC values ranged from 30 to 55. Levofloxacin, owing to its larger AUC0-24 values, has excellent and sustained activity against different pneumococcal strains superior to that of ciprofloxacin.  (+info)

Immune response to Yersinia outer proteins and other Yersinia pestis antigens after experimental plague infection in mice. (3/1104)

There is limited information concerning the nature and extent of the immune response to the virulence determinants of Yersinia pestis during the course of plague infection. In this study, we evaluated the humoral immune response of mice that survived lethal Y. pestis aerosol challenge after antibiotic treatment. Such a model may replicate the clinical situation in humans and indicate which virulence determinants are expressed in vivo. Immunoglobulin G enzyme-linked immunosorbent assay and immunoblotting were performed by using purified, recombinant antigens including F1, V antigen, YpkA, YopH, YopM, YopB, YopD, YopN, YopE, YopK, plasminogen activator protease (Pla), and pH 6 antigen as well as purified lipopolysaccharide. The major antigens recognized by murine convalescent sera were F1, V antigen, YopH, YopM, YopD, and Pla. Early treatment with antibiotics tended to reduce the immune response and differences between antibiotic treatment regimens were noted. These results may indicate that only some virulence factors are expressed and/or immunogenic during infection. This information may prove useful for selecting potential vaccine candidates and for developing improved serologic diagnostic assays.  (+info)

In vitro activities of ketolides HMR 3647 [correction of HRM 3647] and HMR 3004 [correction of HRM 3004], levofloxacin, and other quinolones and macrolides against Neisseria spp. and Moraxella catarrhalis. (4/1104)

In vitro activities of the ketolides HMR 3647 [corrected] and HMR 3004 [corrected] against pathogenic Neisseria gonorrhoeae and N. meningitidis, saprophytic Neisseria isolates, and Moraxella catarrhalis were determined. The comparison of ketolide activities with those of the other macrolides shows a much better activity in the majority of species, with macrolide MICs at which 90% of the isolates are inhibited between 8- and 10-fold higher.  (+info)

The antibacterial efficacy of levofloxacin and ciprofloxacin against Pseudomonas aeruginosa assessed by combining antibiotic exposure and bacterial susceptibility. (5/1104)

Ciprofloxacin has a four-fold greater in-vitro activity than levofloxacin against Pseudomonas aeruginosa, but levofloxacin has a four-fold higher area under the serum concentration-time curve (AUC) for an equivalent dose. It has been proposed that the AUC/MIC ratio is a general predictor of antibacterial efficacy for quinolones. Using an in-vitro kill curve technique, performed in quadruplicate, with nine antibiotic concentrations and three strains of P. aeruginosa with varying quinolone susceptibility, we constructed sigmoidal dose-response curves for AUC(0-6.5)/MIC and area under the bacterial kill curve (AUBKC) or AUC(0-24)/MIC and log change in viable count at 24 h (delta24). For levofloxacin the log AUC(0-6.5)/MIC ratio to produce 50% of the maximal effect was 0.74 +/- 0.13 (r2 = 0.9435) for levofloxacin and 0.82 +/- 0.06 (r2 = 0.7935) for ciprofloxacin. The log AUC(0-24)/MIC ratio to produce 50% maximal effect was 1.58 +/- 0.13 (r2 = 0.7788) for levofloxacin and 1.37 +/- 0.12 (r2 = 0.7207) for ciprofloxacin. An AUC(0-24)/MIC ratio of 125 produced 85.4% of the maximal response with levofloxacin and 81.5% with ciprofloxacin. These data suggest that levofloxacin and ciprofloxacin have equivalent activity against P. aeruginosa at equivalent AUC/MIC ratios.  (+info)

In vitro and in vivo antimicrobial activities of T-3811ME, a novel des-F(6)-quinolone. (6/1104)

The in vitro and in vivo activities of T-3811ME, a novel des-F(6)-quinolone, were evaluated in comparison with those of some fluoroquinolones, including a newly developed one, trovafloxacin. T-3811, a free base of T-3811ME, showed a wide range of antimicrobial spectra, including activities against Chlamydia trachomatis, Mycoplasma pneumoniae, and Mycobacterium tuberculosis. In particular, T-3811 exhibited potent activity against various gram-positive cocci, with MICs at which 90% of the isolates are inhibited (MIC90s) of 0.025 to 6.25 microgram/ml. T-3811 was the most active agent against methicillin-resistant Staphylococcus aureus and streptococci, including penicillin-resistant Streptococcus pneumoniae (PRSP). T-3811 also showed potent activity against quinolone-resistant gram-positive cocci with GyrA and ParC (GrlA) mutations. The activity of T-3811 against members of the family Enterobacteriaceae and nonfermentative gram-negative rods was comparable to that of trovafloxacin. In common with other fluoroquinolones, T-3811 was highly active against Haemophilus influenzae, Moraxella catarrhalis, and Legionella sp., with MIC90s of 0.0125 to 0.1 microgram/ml. T-3811 showed a potent activity against anaerobic bacteria, such as Bacteroides fragilis and Clostridium difficile. T-3811 was the most active agent against C. trachomatis (MIC, 0.008 microgram/ml) and M. pneumoniae (MIC90, 0.0313 microgram/ml). The activity of T-3811 against M. tuberculosis (MIC90, 0.0625 microgram/ml) was potent and superior to that of trovafloxacin. In experimental systemic infection with a GrlA mutant of S. aureus and experimental pneumonia with PRSP in mice, T-3811ME showed excellent therapeutic efficacy in oral and subcutaneous administrations.  (+info)

Pharmacodynamics of trovafloxacin, ofloxacin, and ciprofloxacin against Streptococcus pneumoniae in an in vitro pharmacokinetic model. (7/1104)

An in vitro pharmacokinetic model was used to simulate the pharmacokinetics of trovafloxacin, ofloxacin, and ciprofloxacin in human serum and to compare their pharmacodynamics against eight Streptococcus pneumoniae strains. The MICs of ofloxacin and ciprofloxacin ranged from 1 to 2 micrograms/ml. Trovafloxacin was 8- to 32-fold more potent, with MICs of 0.06 to 0.12 microgram/ml. Logarithmic-phase cultures were exposed to peak concentrations of trovafloxacin, ofloxacin, or ciprofloxacin achieved in human serum after 200-, 400-, and 750-mg oral doses, respectively. Trovafloxacin was dosed at 0 and 24 h, and ofloxacin and ciprofloxacin were dosed at 0, 12, and 24 h. Human elimination pharmacokinetics were simulated, and viable bacterial counts were measured at 0, 2, 4, 6, 8, 12, 24, and 36 h. Trovafloxacin was rapidly and significantly bactericidal against all eight strains evaluated, with viable bacterial counts decreasing at least 5 logs to undetectable levels. Times to 99.9% killing were only 1 to 3 h. Although the rate of killing with ofloxacin was substantially slower than that with trovafloxacin, ofloxacin was also able to eradicate all eight strains from the model, despite a simulated area under the inhibitory curve/MIC ratio (AUC/MIC) of only 49. In contrast, ciprofloxacin eradicated only five strains (AUC/MIC = 44) from the model. Against the other three strains (AUC/MIC = 22), the antibacterial activity of ciprofloxacin was substantially diminished. These data corroborate clinical data and suggest that trovafloxacin has a pharmacodynamic advantage over ciprofloxacin and ofloxacin against S. pneumoniae in relation to its enhanced antipneumococcal activity.  (+info)

Primary Shewanella alga septicemia in a patient on hemodialysis. (8/1104)

We report the first Japanese case of primary septicemia with Shewanella alga and also describe the bacteriological characteristics of and results of antibiotic susceptibility tests of the isolate. S. alga was repeatedly isolated, at times simultaneously with Escherichia coli, from the blood of a 64-year-old female undergoing hemodialysis. The isolated organism was determined to be S. alga based on recently published identification criteria, such as hemolysis on sheep blood agar, no acid production from carbohydrates, and growth on agar containing 6. 5% NaCl. Results of antibiotic susceptibility tests demonstrated that the isolate was sensitive to levofloxacin and cefpirome (MICs, 128, 64, and 8 microg/ml, respectively). Although the role of S. alga as a human pathogen has not been fully determined, accumulating data suggest that this organism may be a potential pathogen, especially in compromised hosts.  (+info)

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Between 0 and 6 h following the administration of a single 200 mg oral dose of ofloxacin to 12 healthy volunteers, the average urine ofloxacin concentration was approximately 220 mcg/mL. Between 12 and 24 hours after administration, the average urine ofloxacin level was approximately 34 mcg/mL.. Following oral administration of recommended therapeutic doses, ofloxacin has been detected in blister fluid, cervix, lung tissue, ovary, prostatic fluid, prostatic tissue, skin, and sputum. The mean concentration of ofloxacin in each of these various body fluids and tissues after one or more doses was 0.8 to 1.5 times the concurrent plasma level. Inadequate data are presently available on the distribution or levels of ofloxacin in the cerebrospinal fluid or brain tissue.. Ofloxacin has a pyridobenzoxazine ring that appears to decrease the extent of parent compound metabolism. Between 65% and 80% of an administered oral dose of ofloxacin is excreted unchanged via the kidneys within 48 hours of dosing. ...
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Results:. Microbiologically documented overall infection rates for norfloxacin, ofloxacin, and ofloxacin plus rifampin were 47%, 24%, and 9%, respectively (P , 0.001). Corresponding rates were 24%, 13%, and 3%, respectively for staphylococcal bacteremia (P = 0.03) and, 21%, 3%, and 3%, respectively for streptococcal bacteremia (P , 0.01). The pattern of bacteremia suggested that rifampin played a role in suppressing staphylococcal infection. Both ofloxacin alone and ofloxacin plus rifampin had a clinically significant antistreptococcal effect. Aerobic gram-negative rods were cleared from rectal surveillance cultures in all patients after a median of 5.5 days and caused infection in only one patient (0.9%). The reductions in the number of microbiologically documented infections among ofloxacin recipients and ofloxacin plus rifampin recipients were offset by concomitant increases in the number of unexplained fevers (24% of norfloxacin recipients, 53% of ofloxacin recipients, and 49% of ofloxacin ...
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To report a case of ofloxacin-associated leucopoenia, which occurred in a patient of falciparum malaria shortly after administration and resolved following discontinuation of the drug. A 44 year old female was admitted in circulatory shock with a diagnosis of falciparum malaria, suffering from fever, diarrhoea and vomiting. After successful resuscitation she was treated with intravenous ofloxacin for Escherichia coli induced diarrhoea. She developed acute leucopoenia that resolved after discontinuation of the drug. Ofloxacin is a broad-spectrum synthetic fluoroquinolone used for a wide variety of bacterial infections. Because of the temporal relationship between ofloxacin administration and the development of leucopenia in our patient, as well as the relationship between drug withdrawal and improvement in white blood cell count, ofloxacin-associated leucopenia was suspected. This reaction was categorized as probable according to the Naranjo probability scale. We report, for the first time in the English
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Abstract:. Ofloxacin is a fluoroquinolones antibacterial agent with a broad spectrum of activity against gram positive and negative bacteria. It is used in urinary and respiratory tract infections, gonorrhea and skin. Conventional doses vary from 200-600 mg twice or thrice a day, as per severity of infection and its biological half-life is 5-6 hrs. In present study, Ofloxacin microspheres were formulated using polymer and natural gums such as Guar gum and Xanthan gum as rate controlling material by ionic crosslinking technique with an aim to prolong its release. All formulations prepared by using different drug-polymer ratios, were evaluated for relevant parameters. Depending upon the drug-polymer ratio of Guar gum, the percentage yield and encapsulation efficiency of microspheres were found to range between 89.17±6.02 to 94.61±4.95% and 78.40±5.08 to 83.89±4.17% respectively. Also the drug to polymer ratio of Xanthan gum, the percentage yield and encapsulation efficiency were found to range ...
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Ofloxacin otic solution is a prescription ear drop used to treat bacterial ear infections. This eMedTV page offers an in-depth look at this drug, providing details on its uses, dosing, possible side effects, general safety precautions, and more.
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Ofloxacin Ophthalmic Solution 0.3% USP, 10MLNDC# 17478-0713-11 This item is non-returnable. This product is a prescription drug. If your State License number is on file we can ship this item to you. Otherwise, please include your State License number in the comments section of the order.
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Active ingredient: Ofloxacin 200 mg Drug class: Antibiotika Indication: Antibiotika Originator: Tarivid® Uro-Tarivid® ► View product page. ...
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Ofloxacin is a quinolone/fluoroquinolone antibiotic. Ofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria ...
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Cerebral venous thrombosis, ischaemia and infarction leading to seizures and headache: case report. Reactions Weekly volume 803, pages7-8(2000)Cite this article ...
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
Abstract: The present study is undertaken to evaluate the antimicrobial properties of a new Fixed Dose Combination (FDC) of Ofloxacin Ornidazole for infusion against some aerobic bacteria in comparison with Ofloxacin and Ornidazole individually. Antibiotic Susceptibility Test (AST) and Minimum Inhibitory Concentration (MIC) of FDC of Ofloxacin Ornidazole, Ofloxacin and Ornidazole for P. aeruginosa, S. aureus, E. coli, K. pneumoniae, S. epidermis and MRSA were determined by disc method and broth micro dilution method. In Antimicrobial Susceptibility Test, lytic zone of combination was found to be more than Ofloxacin or Ornidazole alone in all microbial strains under study. The MIC value of FDC of Ofloxacin Ornidazole was found to be higher than both Ofloxacin and Ornidazole. The data suggests that fixed dose combination of Ofloxacin and Ornidazole can be a good option for use in mixed microbial infection of aerobic bacteria, anaerobic bacteria and pathogenic protozoans. ...
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Objectives: We used two different strains of Escherichia coli, E.coli ATCC 25922 and a recent urinary isolate from a clinical sample, to investigate in vitro how the MIC and mutant prevention concentration (MPC) are affected by different temperatures (37 or 20°C) or oxygen tension (aerobic or anaerobic atmosphere; MIC, MICan; MPC, MPCan).. Materials and methods: MIC and MPC for E.coli ATCC 25922 and the clinical isolate were determined on agar containing ciprofloxacin or levofloxacin, and for the ATCC strain on agar supplemented with nalidixic acid, norfloxacin, ofloxacin, sparfloxacin, trovafloxacin or clinafloxacin.. Results: Results for the ATCC strain and the clinical strain for ciprofloxacin or levofloxacin were similar. The MPC values for E.coli ATCC 25922 were 2 × MIC (trovafloxacin), 4 × MIC (ciprofloxacin, norfloxacin, ofloxacin), 8 × MIC (clinafloxacin, levofloxacin), 16 × MIC (sparfloxacin) and 32 × MIC (nalidixic acid) at 37°C and under aerobic conditions. Generally, a 37°C ...
Obesity is known to affect the concentrations of certain medications in the body. Levofloxacin is a commonly used antibiotic. Based on what the investigators know about levofloxacin and how it moves through the body, obesity may affect levofloxacin concentrations. This study aims to show the effect of obesity on levofloxacin concentrations.. The hypothesis is as follows: A 750 mg intravenous (IV) dose of levofloxacin administered to severely obese, critically ill patients will yield serum concentrations that are likely to be therapeutic. ...
Product Name: Ofloxacin Ophthalmic Solution. Common Name: antibacterial prepration for eye. Strength: 0.3% Ofloxacin. Description: Ofloxacin drops are an ophthalmic fluoroquinolone antibiotic. It stops or prevents bacterial infections of the eyeball by either killing susceptible bacteria or inhibiting their growth. Ofloxacin Ophthalmic Solution 0.3% is a sterile ophthalmic solution. It is a fluorinated carboxyquinolone anti-infective for topical ophthalmic use.. Indications and Usage:. Ofloxacin Ophthalmic Solution is indicated for the treatment of infections caused by susceptible strains of the following bacteria in the conditions listed below:. Conjunctivitis:. ...
Product Name: Ofloxacin and Dexamethasone Sodium Phosphate Eye and Ear Drops. Common Name: antibacterial prepration for eye and ear. Strength: 0.3% Ofloxacin + 0.1% Dexamethasone Sodium Phosphate. Description: Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.. Dexamethasone Sodium Phosphate, a synthetic adrenocortical steroid, is a white or slightly yellow crystalline powder. It is freely soluble in water and is exceedingly hygroscopic.. Indications and Usage:. Ofloxacin and Dexamethasone Sodium Phosphate Eye and Ear Drops is used to treat certain eye conditions due to inflammation or injury. Dexamethasone works by relieving symptoms such as swelling, redness, and itching. It belongs to a class of drugs known as corticosteroids.. This medication may also be used to treat swelling, redness, and itching of the outer ear due to inflammatory conditions.. Pack Size: Ofloxacin and Dexamethasone Sodium Phosphate Eye and Ear Drops ...
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A strain of Mycobacterium tuberculosis resistant to ofloxacin was selected in a patient with a long history of multidrug-resistant tuberculosis eventually treated by ofloxacin combined with other second-line drugs. A mutation in the gyrA gene was hypothesized to be the mechanism of acquired resistan …
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PRIMARY OBJECTIVES:. I. To determine whether levofloxacin given prophylactically during periods of neutropenia to patients being treated with chemotherapy for acute leukemia (AL) or undergoing hematopoietic stem cell transplantation (HSCT) will decrease the incidence of bacteremia.. SECONDARY OBJECTIVES:. I. To determine the effect of prophylactic levofloxacin on resistance patterns of bacterial isolates from all sterile site cultures, and the evolution of antimicrobial resistance from peri-rectal swab isolates of Enterobacteriaceae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Streptococcus mitis.. II. To determine the effect of levofloxacin prophylaxis on total number of days of antibiotic administration (prophylactic, empiric, and treatment) in children undergoing therapy for AL or HSCT.. III. To determine whether levofloxacin prophylaxis reduces the incidence of fever with neutropenia, severe infection, and death from bacterial infection.. IV. To assess the safety of ...
Blood samples were collected at 0 (RMI only), 1, 2, and 6 hours (50 children, aged 6 months to 15 years) after oral levofloxacin at ,6 weeks of treatment. Clinical characteristics and levofloxacin Cmax, elimination half-life (t1/2), and area under the curve from 0 to 24 hours (AUC0-24 hours * µg/mL) were correlated to determine optimal dosage and to examine associations. Population PK and target attainment were modeled. With results from FSM, dosages were increased in RMI toward the target maximal drug concentration (Cmax) for Mycobacterium tuberculosis, 8-12 µg/ml ...
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The development of a new class of antibiotics to fight bacterial resistance is a time-consuming effort associated with high-cost and commercial risks. Thus, modification, conjugation or combination of existing antibiotics to enhance their efficacy is a suitable strategy. We have previously reported that the amphiphilic cyclic peptide [R4W4] had antibacterial activity with a minimum inhibitory concentration (MIC) of 2.97 µg/mL against Methicillin-resistant Staphylococcus aureus (MRSA). Herein, we hypothesized that conjugation or combination of the amphiphilic cyclic peptide [R4W4] with levofloxacin or levofloxacin-Q could improve the antibacterial activity of levofloxacin and levofloxacin-Q. Fmoc/tBu solid-phase chemistry was employed to synthesize conjugates of [R4W4K]-levofloxacin-Q and [R4W4K]-levofloxacin. The carboxylic acid group of levofloxacin or levofloxacin-Q was conjugated with the amino group of β-alanine attached to lysine in the presence of 2-(1H-benzotriazol-1-yl)-1,1,3,3
Levofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Levofloxacin is used to treat different types of bacterial infections. Levofloxacin is also used to treat people who have been exposed to anthrax or certain types of plague. Fluoroquinolone antibiotics can cause serious...
Cefixime and ofloxacin work differently, have different side effects, and come in different forms. While cefixime is a type of...
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If your symptoms do not improve within a few days, or if they become worse, check with your doctor. This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor or nurse right away if you have a rash, itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you take this medicine. Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine. Check with your doctor right away if you have dark urine, clay-colored stools, abdominal or stomach pain, or yellow eyes or skin. These maybe symptoms of a serious liver problem. Ofloxacin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop ...
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Levofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Levofloxacin is used to treat bacterial infections of the skin, sinuses, kidneys, bladder, or prostate. Levofloxacin is also used to treat bacterial infections that cause bronchitis or pneumonia, and to treat people who...
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CNS effects. Headache, dizziness, and drowsiness have been reported with all fluoroquinolones. Insomnia was reported in 3-7% of patients with ofloxacin. Severe CNS effects, including seizures, have been reported in patients receiving trovafloxacin. Seizures may develop within 3 to 4 days of therapy but resolve with drug discontinuation. Although seizures are infrequent, fluoroquinolones should be avoided in patients with a history of convulsion, cerebral trauma, or anoxia. No seizures have been reported with levofloxacin, moxifloxacin, gatifloxacin, and gemifloxacin. With the older non-fluorinated quinolones neurotoxic symptoms such as dizziness occurred in about 50% of the patients ...
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Dolui SK, Das M, Hazra A (2007). "Ofloxacin-induced reversible arthropathy in a child". Journal of Postgraduate Medicine. 53 (2 ...
April 1992). "In vitro and in vivo antibacterial activities of levofloxacin (l-ofloxacin), an optically active ofloxacin". ... It is the left-handed isomer of the medication ofloxacin. Levofloxacin was patented in 1985 and approved for medical use in the ... Daiichi, working with Johnson & Johnson as it had with ofloxacin, obtained FDA approval in 1996 under the brand name Levaquin ... The Daiichi scientists knew that ofloxacin was racemic, but tried unsuccessfully to separate the two isomers; in 1985 they ...
Among those who are older, ofloxacin may be used. Complications include infertility and chronic pain. People aged 15 to 35 are ... For cases caused by enteric organisms (such as E. coli), ofloxacin or levofloxacin are recommended. In children, ...
New research out of India suggests that the combination of rifampin (600 mg), ofloxacin (400 mg), and minocycline hydrochloride ... ofloxacin, and minocycline combination therapy". Archives of Dermatology. 145 (7): 787-9. doi:10.1001/archdermatol.2009.55. ...
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Amorim, CL; Moreira, IS; Maia, AS; Tiritan, ME; Castro, PM (April 2014). "Biodegradation of ofloxacin, norfloxacin, and ...
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  • Brand names for ofloxacin include Ocuflox and Floxin. (medicinenet.com)
  • Fluoroquinolones, including FLOXIN® (ofloxacin) , are associated with an increased risk of tendinitis and tendon rupture in all ages. (rxlist.com)
  • Fluoroquinolones, including FLOXIN® (ofloxacin) , may exacerbate muscle weakness in persons with myasthenia gravis. (rxlist.com)
  • Avoid FLOXIN® (ofloxacin) in patients with a known history of myasthenia gravis (See WARNINGS ). (rxlist.com)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of FLOXIN® (ofloxacin tablets) Tablets and other antibacterial drugs, FLOXIN® (ofloxacin tablets) Tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (rxlist.com)
  • FLOXIN® (ofloxacin tablets) Tablets is a synthetic broad-spectrum antimicrobial agent for oral administration. (rxlist.com)
  • FLOXIN® (ofloxacin) Tablets contain the following inactive ingredients: anhydrous lactose, modified corn starch, hydroxypropyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, polysorbate 80, sodium starch glycolate, titanium dioxide and may also contain synthetic yellow iron oxide. (rxlist.com)
  • Ofloxacin(Floxin) generic Duof is a fluoroquinolone antibiotic, prescribed for certain types of bacterial infections such as chronic bronchitis, pneumonia, skin and skin structure infections, and others. (medindia.net)
  • Commonly known as Ofloxacin, Floxin is a top-notch medication used to fight bacteria in the human body. (avalonpharmacy.com)
  • Brand name: Floxin Generic name: Ofloxacin Why is Floxin prescribed? (medicinesmexico.com)
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  • Your doctor may prescribe Floxin or generic Ofloxacin to treat many bacterial infections, including urinary tract, joint, and bone infections or respiratory infections such as pneumonia and bronchitis. (discountdrugsfromcanada.com)
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  • Teva Pharmaceuticals USA (North Wales, Pa) recently announced the introduction and availability of Ofloxacin Tablets. (pharmacytimes.com)
  • Ofloxacin Tablets are indicated for the treatment of adults with mild-to-moderate infections (unless otherwise indicated) caused by susceptible strains of designated microorganisms. (pharmacytimes.com)
  • Ofloxacin Tablets 200, 300, and 400 mg are available in bottle sizes of 100. (pharmacytimes.com)
  • The single dose and steady-state plasma profiles of ofloxacin injection were comparable in extent of exposure (AUC) to those of ofloxacin tablets when the injectable and tablet formulations of ofloxacin were administered in equal doses (mg/mg) to the same group of subjects. (nih.gov)
  • The price for ofloxacin tablets can vary significantly by location, potentially ranging from about $70 to $340. (internetdrugcoupons.com)
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  • Ornof (ofloxacin) tablets Active ingredients: Each coated Ornof tabs contain ornidazole 500 mg and ofloxacin 200 mg. (knoji.com)
  • These may not be the complete list of possible side effects associated to Ornof (ofloxacin) tablets, consult a doctor for detailed information. (knoji.com)
  • Antacids may decrease absorption of ofloxacin (ornof tablets), do not use antacids two hour before or after using Ornof tabs. (knoji.com)
  • Ofloxacin is in a class of antibiotics called fluoroquinolones. (medlineplus.gov)
  • Antibiotics such as ofloxacin will not work for colds, flu, or other viral infections. (medlineplus.gov)
  • If you stop using ofloxacin otic too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • Suprax and ofloxacin are antibiotics used to treat bronchitis , pneumonia , urinary tract infections ( UTIs ), and gonorrhea . (medicinenet.com)
  • Suprax and ofloxacin are different types of antibiotics. (medicinenet.com)
  • Ofloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics have been associated with tendinitis and even rupture of tendons, particularly the Achilles tendon. (medicinenet.com)
  • Many antibiotics, including ofloxacin, can alter the normal bacteria in the colon and encourage overgrowth of a bacterium ( Clostridium difficile ) responsible for the development of inflammation of the colon (pseudomembranous colitis ). (medicinenet.com)
  • Quinolone antibiotics (including ofloxacin ) may cause serious and possibly permanent tendon damage (such as tendonitis , tendon rupture), nerve problems in the arms and legs ( peripheral neuropathy ), and nervous system problems. (webmd.com)
  • Ofloxacin belongs to a class of drugs called quinolone antibiotics . (webmd.com)
  • Ofloxacin belongs to a form of antibiotics known as quinolones. (reference.com)
  • Even though cefizime and ofloxacin do not belong to the same group (cephalosporins are similar to penicillin), they are both very effective and safe antibiotics. (wisegeek.com)
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  • Antibiotics tested included chloramphenicol and tetracycline (from 1993 to 1996) and ofloxacin (added in routine testing from 1997). (cdc.gov)
  • The active ingredient, Ofloxacin, belongs to a class of medicines called quinolone antibiotics which work at the genetic level to stop bacteria from multiplying so the infection doesn't spread and quickly dies. (vetrxdirect.com)
  • Ofloxacin 200mg + Ornidazole 500mg Tablet. (tradeindia.com)
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  • I am taking ofloxacin 100 mg and norfloxacin 400mg combined 2 times a day to kill possible urinary tract infection. (healthtap.com)
  • Ofloxacin is a quinolone antibiotic useful for the treatment of a number of bacterial infections. (wikipedia.org)
  • Ofloxacin is used in the treatment of bacterial infections such as: Acute bacterial exacerbations of COPD Community-acquired pneumonia Uncomplicated skin and skin structure infections Nongonococcal urethritis and cervicitis Epididymitis Mixed Infections of the urethra and cervix Acute pelvic inflammatory disease Uncomplicated cystitis Complicated urinary tract infections Prostatitis Acute, uncomplicated urethral and cervical gonorrhea Ofloxacin has not been shown to be effective in the treatment of syphilis. (wikipedia.org)
  • Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections such as pneumonia , bronchitis, staph infections, STDs (gonorrhea, chlamydia ), urinary tract infections, and prostate infections caused by E. coli . (medicinenet.com)
  • Ofloxacin is an antibiotic used to treat bacterial infections of the eye, such as conjunctivitis and corneal ulcers. (mayoclinic.org)
  • Ofloxacin is a "fluoroquinolone" antibiotic used to treat bacterial infections . (adventisthealthcare.com)
  • Ofloxacin ophthalmic (for use in the eyes) is used to treat bacterial infections of the eyes. (peacehealth.org)
  • Ofloxacin ophthalmic is for use in treating only bacterial infections of the eye. (peacehealth.org)
  • Ofloxacin is an antibiotic that may be used to treat certain types of bacterial infections. (internetdrugcoupons.com)
  • Depending on its form, ofloxacin may be used to treat bacterial infections of the skin, eyes, urinary tract, or prostate. (internetdrugcoupons.com)
  • Ofloxacin is used to treat several types of bacterial infections. (rxwiki.com)
  • Ofloxacin is a prescription medication used to treat certain bacterial infections including bronchitis, pneumonia, and infections of the skin, bladder, urinary tract, reproductive organs,and prostate (a male reproductive gland).Ofloxacin also treats bacterial infections of the ears and eyes.Ofloxacin belongs to a group of drugs called fluoroquinolone antibiotics. (rxwiki.com)
  • Ofloxacin is a prescription medication that is used to treat bacterial infections of the ears and eyes. (rxwiki.com)
  • Talk to your pet's veterinarian or pharmacist if you do not understand any of the information provided in this document or if you have any questions about Ofloxacin to treat bacterial infections in dogs and cats' eyes. (vetrxdirect.com)
  • Ofloxacin is used to treat bacterial infections of the skin, lungs, prostate, or urinary tract (bladder and kidneys). (uncmedicalcenter.org)
  • Available by prescription only, ofloxacin otic solution can help treat certain bacterial infections of the middle or outer ear. (emedtv.com)
  • According to the product package insert, ofloxacin is effective against these microorganisms: Aerobic Gram-positive microorganisms: Staphylococcus aureus (methicillin-susceptible strains) Streptococcus pneumoniae (penicillin-susceptible strains) Streptococcus pyogenes Aerobic Gram-negative microorganisms Citrobacter koseri (Citrobacter diversus) Enterobacter aerogenes Escherichia coli Haemophilus influenzae Klebsiella pneumoniae Neisseria gonorrhoeae Proteus mirabilis Pseudomonas aeruginosa Other microorganisms: Chlamydia trachomatis In general, fluoroquinolones are well tolerated, with most side effects being mild to moderate. (wikipedia.org)
  • Ofloxacin eye drops belong to the group of medications called fluoroquinolones . (medbroadcast.com)
  • You should not use this medicine if you are allergic to ofloxacin or other fluoroquinolones (ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, and others). (peacehealth.org)
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  • J01MA01 - ofloxacin is from the family of fluoroquinolones and is administered for the routine therapy and systemic management of infections. (knoji.com)
  • VRX ) today announced the relaunch of its generic ofloxacin otic solution to treat bacterial ear infections. (newswire.ca)
  • The ofloxacin otic solution began shipping to customers on August 1, 2016 and will be available at most major retailers across the U.S. (newswire.ca)
  • My 6 year old had a bad ear ache so i gave him ofloxacin otic solution l10 hrs later he has no pain but cant hear out of his ear/ continue antibiotic? (healthtap.com)
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  • Click Side Effects of Ofloxacin Otic Solution to learn more, including potentially serious side effects that you should report immediately to your healthcare provider. (emedtv.com)
  • Your doctor may tell you not to take ofloxacin. (medlineplus.gov)
  • If you have myasthenia gravis and your doctor tells you that you should take ofloxacin, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment. (medlineplus.gov)
  • Patients can take cefixime with or without food but cannot take ofloxacin within two hours of consuming antacids , dairy products, or multivitamins. (wisegeek.com)
  • Can I take Ofloxacin Ophthalmic (Ocuflox) if I'm pregnant or breastfeeding? (everydayhealth.com)
  • Take ofloxacin 2 hours before or 2 hours after these medicines to offset this effect. (speranta.tv)
  • How should I take ofloxacin? (uncmedicalcenter.org)
  • Take ofloxacin with water, and drink extra fluids to keep your kidneys working properly. (uncmedicalcenter.org)
  • You may take ofloxacin with or without food, at the same time each day. (uncmedicalcenter.org)
  • Take ofloxacin with a full glass of water (8 ounces). (indiapharmaexports.com)
  • Take ofloxacin on an empty stomach 1 hour before or 2 hours after meals. (indiapharmaexports.com)
  • You may not be able to take ofloxacin, or you may require a dosage adjustment or special monitoring during treatment. (indiapharmaexports.com)
  • What Is Ofloxacin Ophthalmic Solution USP? (reference.com)
  • Ofloxacin Ophthalmic Solution USP is a type of anti-infective agent that is intended to treat eye infections. (reference.com)
  • Ofloxacin Ophthalmic Solution is a bactericidal antimicrobial given with other antibacterial agents are ineffective. (medi-vet.com)
  • Axerophthol ofloxacin ophthalmic solution over the counter helps the correlation of the past, mucosa membranes and stampede be ofloxacin ophthalmic solution over the counter barriers to feel and viruses, reducing the required of eye muscles, metabolic process issues and trying different destinations. (revolutionhealthaz.com)
  • In the surplice of a ofloxacin ophthalmic solution over the counter overdose, ride the eye with a associated ocular irrigant. (revolutionhealthaz.com)
  • Exocin eye drops contain the active ingredient ofloxacin, which is a type of medicine called a quinolone antibiotic. (netdoctor.co.uk)
  • Ofloxacin eye drops (solution) are not approved for use by anyone younger than 1 year old. (peacehealth.org)
  • Common side effects of ofloxacin eye drops include eye discomfort, tearing, and dryness. (rxwiki.com)
  • Common side effects of ofloxacin ear drops include itching, ear pain, and headache. (rxwiki.com)
  • Prescription Ofloxacin Eye Drops stop bacterial eye infections in their tracks and give dogs and cats quick relief from pain, swelling, itching and discomfort. (vetrxdirect.com)
  • To treat bacterial eye infections, veterinarians often prescribe Ofloxacin Eye Drops, a broad-spectrum topical antibiotic. (vetrxdirect.com)
  • To learn what pet parents think about Ofloxacin Eye Drops, click the "Reviews" tab above. (vetrxdirect.com)
  • For additional information about Ofloxacin Eye Drops , click the "More Information" and "Package Insert" tabs above. (vetrxdirect.com)
  • This information is written for product use in people, but may be helpful to you when giving the Ofloxacin Eye Drops to your pet. (vetrxdirect.com)
  • Ofloxacin works by killing the bacteria that are causing an infection. (netdoctor.co.uk)
  • Administering them directly into the eye allows the ofloxacin to act directly on the bacteria that are causing the infection. (netdoctor.co.uk)
  • Ofloxacin stops the multiplication of bacteria by inhibiting the reproduction and repair of their genetic material (DNA). (medicinenet.com)
  • Cefixime and ofloxacin have a number of differences including the mechanism by which they eradicate bacteria and the risks and side effects involved in taking the medication. (wisegeek.com)
  • While both cefixime and ofloxacin effectively eradicate similar strains of bacteria, ofloxacin's different chemical structure and method of killing bacteria make many microbes less resistant to it. (wisegeek.com)
  • Ofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. (peacehealth.org)
  • The present study is undertaken to evaluate the antimicrobial properties of a new Fixed Dose Combination (FDC) of Ofloxacin Ornidazole for infusion against some aerobic bacteria in comparison with Ofloxacin and Ornidazole individually. (scialert.net)
  • The data suggests that fixed dose combination of Ofloxacin and Ornidazole can be a good option for use in mixed microbial infection of aerobic bacteria, anaerobic bacteria and pathogenic protozoans. (scialert.net)
  • Like other quinolones, ofloxacin works by killing certain bacteria that cause infections. (emedtv.com)
  • Ofloxacin fights bacteria in the body. (indiapharmaexports.com)
  • What is the recommended dosage of Nitazoxanide-Ofloxacin? (internationaldrugmart.com)
  • The dosage of Nitazoxanide-Ofloxacin prescribed to each patient will vary. (internationaldrugmart.com)
  • The recommendation of some authors that, in general, ofloxacin dosage may be halved in the elderly could not be confirmed. (springer.com)
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  • Since the AUC in mice treated with ofloxacin 150 mg/kg daily is close to that in man treated with a clinically tolerated dose-600 mg daily-such a dosage may be only moderately effective against human tuberculosis. (elsevier.com)
  • Ofloxacin is used to treat certain infections including pneumonia, and infections of the skin, bladder, reproductive organs, and prostate (a male reproductive gland). (medlineplus.gov)
  • Ofloxacin may also be used to treat bronchitis and urinary tract infections but should not be used for bronchitis and some types of urinary tract infections if other treatments are available. (medlineplus.gov)
  • Ofloxacin otic is used to treat outer ear infections in adults and children, chronic (long-lasting) middle ear infections in adults and children with a perforated eardrum (a condition where the eardrum has a hole in it), and acute (suddenly occurring) middle ear infections in children with ear tubes. (medlineplus.gov)
  • Ofloxacin otic is a quinolone antibiotic solution used to treat outer ear infections in adults and children, chronic middle ear infections in adults and children with perforated eardrums, and acute middle ear infections in children with ear tubes. (newswire.ca)
  • Ofloxacin is available in special preparations to treat eye infections and ear infections . (adventisthealthcare.com)
  • It's important to note that due to the risk of side effects, ofloxacin is usually only prescribed for infections that can't be treated with a safer antibiotic. (internetdrugcoupons.com)
  • Ofloxacin is only for bacterial eye infections and is not effective on other types of infections. (vetrxdirect.com)
  • Ofloxacin should be used only for infections that cannot be treated with a safer antibiotic. (uncmedicalcenter.org)
  • S01AX11 - ofloxacin is from the family of other anti-infective and is administered for treating eye infections. (knoji.com)
  • If you experience any of the following symptoms of tendon rupture, stop taking ofloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or bear weight on an affected area. (medlineplus.gov)
  • Taking ofloxacin may cause changes in sensation and nerve damage that may not go away even after you stop taking ofloxacin. (medlineplus.gov)
  • This can happen during treatment or up to several months after you stop taking ofloxacin. (uncmedicalcenter.org)
  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ofloxacin. (medlineplus.gov)
  • You should begin to feel better during the first few days of treatment with ofloxacin otic. (medlineplus.gov)
  • Ofloxacin may cause low or high blood sugar levels especially in people with diabetes who are taking insulin or oral hypoglycemic drugs. (medicinenet.com)
  • Developmental problems have been reported in two infants exposed to ofloxacin in breastmilk, but their mothers were also exposed to several drugs during pregnancy and during breastfeeding, so the problems cannot necessarily be attributed to ofloxacin. (nih.gov)
  • Another difference between the two drugs is that ofloxacin is a category C drug for pregnant women and cefixime is a category B drug. (wisegeek.com)
  • What other drugs could interact with Nitazoxanide-Ofloxacin? (internationaldrugmart.com)
  • Is it possible for me to take Nitazoxanide-Ofloxacin with other drugs? (internationaldrugmart.com)
  • A strain of Mycobacterium tuberculosis resistant to ofloxacin was selected in a patient with a long history of multidrug-resistant tuberculosis eventually treated by ofloxacin combined with other second-line drugs. (nih.gov)
  • Use your discount card for ofloxacin or any other qualifying drugs that aren't covered by your insurance. (internetdrugcoupons.com)
  • In view of the marked variation in the kinetic behaviour of antimicrobial drugs amongst species, the present study was undertaken to determine the pharmacokinetics, in vitro plasma protein binding and urinary excretion following a single intravenous administration of ofloxacin in water buffalo calves. (scielo.org.za)
  • Ofloxacin parade solution has been mistranslated to be advised in vitro against most ofloxacin drugs class of these chemicals but the additional ofloxacin drug class in ophthalmologic adapters is dose. (revolutionhealthaz.com)
  • Ofloxacin is available as a generic medication. (wikipedia.org)
  • Patients with central nervous system diseases such as seizures should use ofloxacin with caution, because rare seizures have been reported in patients receiving this medication. (medicinenet.com)
  • Read the Medication Guide provided by your pharmacist before you start taking ofloxacin and each time you get a refill. (webmd.com)
  • Ofloxacin ophthalmic may also be used for purposes not listed in this medication guide. (peacehealth.org)
  • Order your medication online 24 hours a day 365 days a year cefixime 200 mg ofloxacin 200 mg . (spiritofbaraka.com)
  • Nitazoxanide-Ofloxacin is an antiparasitic and antibacterial medication used in the treatment of diarrhea. (internationaldrugmart.com)
  • If your physician has instructed or directed you to take Nitazoxanide-Ofloxacin medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. (internationaldrugmart.com)
  • Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Nitazoxanide-Ofloxacin, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions. (internationaldrugmart.com)
  • If your insurance won't cover this medication and you're looking for a way to save, get a free ofloxacin coupon or discount card from our site. (internetdrugcoupons.com)
  • t is ofloxacin drug class if this medication passes into trouble milk. (revolutionhealthaz.com)
  • Taking ofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. (medlineplus.gov)
  • Risks associated with ofloxacin also include tendon ruptures, a danger that increases in patients using corticosteroids and in individuals over the age of 60. (wisegeek.com)
  • Ofloxacin can cause serious side effects, including tendon problems, nerve damage, serious mood or behavior changes, or low blood sugar. (uncmedicalcenter.org)
  • Ofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body) , especially in the Achilles' tendon of the heel. (uncmedicalcenter.org)
  • Drug interactions differ between cefixime and ofloxacin. (wisegeek.com)
  • Ofloxacin may have major interactions with twice as many medications as cefixime, including anticoagulant, antipsychotic, and oral diabetic medications. (wisegeek.com)
  • Ferric effort has been made to examine that the cannabis provided by Cerner Multum, Inc. 'Multum' is important, up-to-date, and stuck, but no generic is made to that dim and ofloxacin interactions . (revolutionhealthaz.com)
  • 0001). The greater concentration of ofloxacin in ocular tissue coupled with its superior antibacterial activity profile supports its use as an alternative to trimethoprim/polymyxin B for treatment of bacterial conjunctivitis. (nih.gov)
  • Since then, more O1 strains were isolated that exhibited reduced antibiotic susceptibilities to chloramphenicol and tetracycline but not to ofloxacin (12) . (cdc.gov)
  • MIC90s of ofloxacin for O139 were nearly 10 times higher than those for O1 strains. (cdc.gov)
  • Preliminary results using pulsed-field gel electrophoresis analysis of chromosomal DNA showed that these ofloxacin-resistant O139 strains had identical fingerprint patterns and probably belonged to the clone that had caused severe diarrheal disease in the region. (cdc.gov)
  • Two previous surveys of V. cholerae antibiotic susceptibilities had not described any ofloxacin-resistant O139 strains ( 15 , 16 ). (cdc.gov)
  • Chromosomal DNA of strains MTB1, isolated before treatment and susceptible to ofloxacin (MIC, 1 microgram/mL), and MTB2, isolated during treatment and resistant to ofloxacin (MIC, 32 micrograms/mL), was amplified by polymerase chain reaction (PCR) using two oligonucleotide primers highly homologous to DNA sequences flanking the quinolone resistance-determining region in gyrA of mycobacteria. (nih.gov)
  • In Antimicrobial Susceptibility Test, lytic zone of combination was found to be more than Ofloxacin or Ornidazole alone in all microbial strains under study. (scialert.net)
  • In this work, we studied the variation in the gyrA and gyrB genes in ofloxacin- and multidrug-resistant Mycobacterium tuberculosis strains circulating in northwest Russia. (asm.org)
  • In 2006, the rate of ofloxacin (OFL)-resistant M. tuberculosis strains was in the range of 1.1 to 1.6% for patients newly diagnosed with tuberculosis and 4.1 to 10.3% for previously treated patients in different regions of northwest Russia. (asm.org)
  • The minimal inhibitory concentrations for 90% of strains (MIC90) of ofloxacin against Mycobacterium tuberculosis and Mycobacterium xenopi was 2 mg/I. This was three dilutions lower than that of pefloxacin and was well within the range of drug concentrations achievable in man. (elsevier.com)
  • Ciprofloxacin, ofloxacin, and levofloxacin inhibit 90% of the strains of susceptible tubercula bacilli at concentrations of less than 2 ^g/mL. (alpfmedical.info)
  • In vitro activity of ciprofloxacin, sparfloxacin, ofloxacin, amikacin and rifampicin against Ghanaian isolates of Mycobacterium ulcerans. (nih.gov)
  • MICs of ciprofloxacin, sparfloxacin, ofloxacin, amikacin and rifampicin were determined for 14 primary clinical isolates and three reference isolates of Mycobacterium ulcerans by modifying a standard agar dilution method for testing Mycobacterium tuberculosis sensitivity. (nih.gov)
  • Bactericidal activity of a single-dose combination of ofloxacin plus minocycline, with or without rifampin, against Mycobacterium leprae in mice and in lepromatous patients. (ajtmh.org)
  • Pre-XDR & XDR in MDR and Ofloxacin and Kanamycin resistance in non-MDR Mycobacterium tuberculosis isolates. (msf.org)
  • In vitro activity of ciprofloxacin, ofloxacin and levofloxacin against Mycobacterium tuberculosis. (msf.org)
  • Levofloxacin is preferred because it is the active l-optical isomer of ofloxacin and is approved for once-daily use. (alpfmedical.info)
  • Between 0 and 6 h following the administration of a single 200 mg oral dose of ofloxacin to 12 healthy volunteers, the average urine ofloxacin concentration was approximately 220 mcg/mL. (nih.gov)
  • The pharmacokinetics of ofloxacin following a single 200 mg oral dose were studied in twelve healthy elderly volunteers. (springer.com)
  • Use ofloxacin otic until you finish the prescription, even if you feel better. (medlineplus.gov)
  • Ofloxacin is available only with your doctor's prescription. (mayoclinic.org)
  • Print, email, or text yourself an ofloxacin coupon now to save 20-75% on each prescription fill. (internetdrugcoupons.com)
  • On december large she was lying in ofloxacin prescription canada tainly unwilling. (thevhf.com)
  • I remember this previous patient, while receiving apt priori uremia after one of her certain fields, experiencing not several kidney and horizontal genitals that produced an present non prescription alternatives to ofloxacin of method followed by a absolutely last profession of failure that not proved aortic. (thevhf.com)
  • Other pages may give ofloxacin, including prescription and is ofloxacin over the counter upanishads, vitamins, and herbal products or what is ofloxacin ophthalmic used for . (revolutionhealthaz.com)
  • What is Ofloxacin Ophthalmic (Ocuflox) used for? (everydayhealth.com)
  • Use Ofloxacin Ophthalmic (Ocuflox) exactly as directed on the label, or as prescribed by your doctor. (everydayhealth.com)
  • Taking ofloxacin may affect your brain or nervous system and cause serious side effects. (medlineplus.gov)
  • Ofloxacin otic may cause side effects. (medlineplus.gov)
  • Side effects of Suprax that are different from ofloxacin include abdominal pain , skin rash , fever , joint pain , and abnormal liver tests . (medicinenet.com)
  • Side effects of ofloxacin that are different from Suprax include insomnia , allergic reactions (such as hives and anaphylaxis ), skin sensitivity ( photosensitivity ), anxiety , euphoria , and hallucinations . (medicinenet.com)
  • What are the side effects of Suprax and ofloxacin? (medicinenet.com)
  • Read user comments about the side effects, benefits, and effectiveness of ofloxacin oral. (webmd.com)
  • Gastrointestinal side effects are common with both cefixime and ofloxacin. (wisegeek.com)
  • Ofloxacin side effects include central nervous system symptoms that may include confusion, dizziness , or convulsions. (wisegeek.com)
  • Like other medicines, Nitazoxanide-Ofloxacin can cause some side effects. (internationaldrugmart.com)
  • If they do occur, the side effects of Nitazoxanide-Ofloxacin are most likely to be minor and temporary. (internationaldrugmart.com)
  • It is pertinent to note that side effects of Nitazoxanide-Ofloxacin cannot be anticipated. (internationaldrugmart.com)
  • If any side effects of Nitazoxanide-Ofloxacin develop or change in intensity, the doctor should be informed as soon as possible. (internationaldrugmart.com)
  • Serious side effects have been reported with ofloxacin. (rxwiki.com)
  • This is not a complete list of ofloxacin side effects. (rxwiki.com)
  • When taking ofloxacin, the side effects a person experiences will be based on the particular form of ofloxacin that is used. (emedtv.com)
  • This article covers many, but not all, of the possible side effects with ofloxacin. (emedtv.com)
  • Some ofloxacin side effects, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. (emedtv.com)
  • This can occur after the first dose of ofloxacin. (medlineplus.gov)
  • Avoiding breastfeeding for 4 to 6 hours after a dose should decrease the exposure of the infant to ofloxacin in breastmilk. (nih.gov)
  • Milk ofloxacin was measured after the third dose. (nih.gov)
  • Physicians typically prescribe 400 milligrams of cefixime once daily while an ofloxacin dose may be 400 to 800 milligrams per day divided into two doses and taken once every 12 hours. (wisegeek.com)
  • Absorption of ofloxacin after single or multiple doses of 200 to 400 mg is predictable, and the amount of drug absorbed increases proportionately with the dose. (nih.gov)
  • What if you miss a dose of Nitazoxanide-Ofloxacin? (internationaldrugmart.com)
  • The enantioselective disposition of ofloxacin (OFLX) was studied in healthy subjects after oral administration of (+/-)-OFLX at a dose of 200 mg. (asm.org)
  • On the contrary, a dose-depend inhibition of proliferation and decrease of cell viability was detected with ofloxacin treatment. (arvojournals.org)
  • Single skin lesion paucibacillary leprosy volunteers ( N = 135) recruited in three Brazilian endemic regions, treated with single-dose rifampin, ofloxacin, and minocycline (ROM), were monitored for 3 years. (ajtmh.org)
  • Pharmacokinetics and urinary excretion of an intravenous dose of 5 mg.kg -1 ofloxacin were investigated in water buffalo calves. (scielo.org.za)
  • Ofloxacin was administered at a dose of 5 mg.kg -1 body weight into the left jugular vein. (scielo.org.za)
  • Computer predictions of a multiple 200 mg dose regimen showed no important accumulation of ofloxacin. (springer.com)
  • The therapeutic effects of ofloxacin against M. tuberculosis infection were dose-related: 300 mg/kg daily by gavage or 0.4% in mouse diet displayed much better therapeutic effects than lower dosages. (elsevier.com)
  • Tums or Rolaids), the ulcer medicine sucralfate (Carafate), or vitamin or mineral supplements that contain iron or zinc for a minimum of 2 hours before or 2 hours after a dose of ofloxacin. (indiapharmaexports.com)
  • Taking antacids, sucralfate, or vitamin or mineral supplements too close to a dose of ofloxacin can greatly decrease the effects of the antibiotic. (indiapharmaexports.com)
  • The prophylactic efficacy of ofloxacin (OFLX) therapy was evaluated in 51 granulocytopenic episodes in 22 patients with hematological malignancies during post-remission chemotherapy in a prospective, randomized, controlled trial. (eurekamag.com)
  • May decrease oral absorption of ofloxacin. (drugs.com)
  • The following are mean peak serum concentrations in healthy 70 to 80 kg male volunteers after single oral doses of 200, 300, or 400 mg of ofloxacin or after multiple oral doses of 400 mg. (nih.gov)
  • Pharmacokinetics of ofloxacin after parenteral and oral administration. (springer.com)
  • Method for the determination of ofloxacin, a quinolone carboxylic acid antimicrobial, by high-performance liquid chromatography. (springer.com)
  • Suprax is a cephalosporin antibiotic and ofloxacin is a fluoroquinolone antibiotic. (medicinenet.com)
  • Ofloxacin is a fluoroquinolone antibiotic and works by inhibiting the bacterial DNA gyrase enzyme, causing damage to the bacterial DNA. (medi-vet.com)
  • Can I substitute ciprofloxacin with ofloxacin for pharyngitis? (ndtv.com)
  • Home » Frequently asked Questions on Health » Can I substitute ciprofloxacin with ofloxacin for pharyngitis? (ndtv.com)
  • Assuming that a throat swab does show bacterial growth, then appropriate antibiotic can be taken to which grown germs are sensitive which may or may not be a quinolone (norfloxacin, ciprofloxacin, ofloxacin, lomefloxacin, gatifloxacin, pefloxacin) but an antibiotic such as amoxycillin, ampicillin etc. (ndtv.com)
  • Ofloxacin is in the fluoroquinolone family of medications. (wikipedia.org)
  • Cefixime belongs to the group of medications known as cephalosporins, and ofloxacin is a fluoroquinolone. (wisegeek.com)
  • Ofloxacin inhibits the enzymes necessary to metabolize carbamazepine or warfarin, increasing the blood levels and actions of these medications. (wisegeek.com)
  • Maxalt online apotheke - No rx required when buying your medications cefixime and ofloxacin combination in typhoid fever . (spiritofbaraka.com)
  • We always offer reusable coupons for ofloxacin and many other medications. (internetdrugcoupons.com)
  • Ten lactating women (time postpartum not stated) were given ofloxacin 400 mg orally every 12 hours for 3 doses. (nih.gov)
  • The mean concentration of ofloxacin in each of these various body fluids and tissues after one or more doses was 0.8 to 1.5 times the concurrent plasma level. (nih.gov)
  • Monthly doses of rifampin, ofloxacin, and minocycline (ROM) are expected to be effective treatment for multi-bacillary leprosy. (ajtmh.org)
  • Treatment with ROM was given as 24 consecutive monthly observed doses of rifampin (600 mg), ofloxacin (400 mg), and minocycline (100 mg). (ajtmh.org)
  • Plasma concentrations of ofloxacin were determined by high-performance liquid chromatography. (scielo.org.za)
  • The novel appearance of O139 resistant to ofloxacin with MICs of 16 µg/ml from Guangdong Province, China, was of special concern. (cdc.gov)
  • Of 13 V. cholerae O139 isolates tested, 7 showed intermediate resistance to chloramphenicol and high-level resistance to ofloxacin (MIC 16 µg/ml) but no resistance to tetracycline (MIC 50s and MIC 90s were 0.25 µg/ml). (cdc.gov)
  • A mutation in the gyrA gene was hypothesized to be the mechanism of acquired resistance to ofloxacin in this strain. (nih.gov)
  • 2008). However, there is little information available on the pharmacokinetics of ofloxacin in buffalo species. (scielo.org.za)
  • How is it that you knew you were allergic to Ofloxacin and you let your doctor prescribe it anyway? (healthtap.com)
  • Ofloxacin was used as part of multidrug regimens to treat two pregnant women with multidrug-resistant tuberculosis, one throughout pregnancy and postpartum and the other postpartum only. (nih.gov)
  • Moxifloxacin Improves Treatment Outcomes in Patients with Ofloxacin-Resistant Multidrug-Resistant Tuberculosis. (msf.org)
  • What should I discuss with my healthcare provider before ofloxacin ophthalmic? (peacehealth.org)
  • Ofloxacin is in the FDA pregnancy category C. This means that it is not known whether ofloxacin will be harmful to an unborn baby. (indiapharmaexports.com)
  • The aim of this study was to investigate the possible in vitro cytotoxic effect of both netilmicin (an aminoglycoside agent) and ofloxacin (a fluoroquinolone agent) on human conjunctival epithelial cells. (arvojournals.org)
  • The results of the study indicated a favourable pharmacokinetic profile of ofloxacin in water buffalo calves, which suggests that ofloxacin may be effective against urinary pathogens in this species. (scielo.org.za)
  • Ofloxacin is an antibiotic that would typically be effective in a urinary tract infection. (healthtap.com)
  • Can ofloxacin and ceftriaxone be taken together for an e coli urinary tract infection? (healthtap.com)
  • V. cholerae isolates available for further study were tested with the standard broth microdilution method (11) to measure minimum inhibitory concentrations (MICs) of susceptibilities to chloramphenicol, tetracycline, and ofloxacin. (cdc.gov)
  • A continuous human conjunctival cell line (Wong-Kilbourne-derivative of Chang conjunctiva, ATCC) was exposed to a preservative-free solution containing either netilmicin or ofloxacin at various concentrations (up to 5 mg/mL). (arvojournals.org)
  • Our results suggest that, at clinically used concentrations, netilmicin is not cytotoxic, whereas ofloxacin has significant antiproliferative and cytotoxic effects for conjunctival cells. (arvojournals.org)
  • Cimetidine possibly might boost ofloxacin concentrations. (knoji.com)
  • Générique azithromycin pilule pharmacie patch et cefixime 200 mg ofloxacin 200 mg . (spiritofbaraka.com)
  • The recently published study by Romero-Aroca et al 1 raises interesting questions regarding the effect of choice of topical antibiotic (azithromycin versus ofloxacin) on the incidence of endophthalmitis following intravitreal injections. (dovepress.com)
  • First, the authors state that use of azithromycin leads to significantly fewer cases of post-injection endophthalmitis than does the use of ofloxacin. (dovepress.com)
  • Ofloxacin , ceftriaxone, and azithromycin. (revolutionhealthaz.com)