Cylindrical epithelial cells in the innermost layer of the ENAMEL ORGAN. Their functions include contribution to the development of the dentinoenamel junction by the deposition of a layer of the matrix, thus producing the foundation for the prisms (the structural units of the DENTAL ENAMEL), and production of the matrix for the enamel prisms and interprismatic substance. (From Jablonski's Dictionary of Dentistry, 1992)
Epithelial cells surrounding the dental papilla and differentiated into three layers: the inner enamel epithelium, consisting of ameloblasts which eventually form the enamel, and the enamel pulp and external enamel epithelium, both of which atrophy and disappear before and upon eruption of the tooth, respectively.
The most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces. (Jablonski, Dictionary of Dentistry, 1992, p821)
MSX1 Transcription Factor
The formation of dentin. Dentin first appears in the layer between the ameloblasts and odontoblasts and becomes calcified immediately. Formation progresses from the tip of the papilla over its slope to form a calcified cap becoming thicker by the apposition of new layers pulpward. A layer of uncalcified dentin intervenes between the calcified tissue and the odontoblast and its processes. (From Jablonski, Dictionary of Dentistry, 1992)
Bone Morphogenetic Protein 4
A hard thin translucent layer of calcified substance which envelops and protects the dentin of the crown of the tooth. It is the hardest substance in the body and is almost entirely composed of calcium salts. Under the microscope, it is composed of thin rods (enamel prisms) held together by cementing substance, and surrounded by an enamel sheath. (From Jablonski, Dictionary of Dentistry, 1992, p286)
Gene Expression Regulation, Developmental
Bone Morphogenetic Proteins
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
In Situ Hybridization
Cysts found in the jaws and arising from epithelium involved in tooth formation. They include follicular cysts (e.g., primordial cyst, dentigerous cyst, multilocular cyst), lateral periodontal cysts, and radicular cysts. They may become keratinized (odontogenic keratocysts). Follicular cysts may give rise to ameloblastomas and, in rare cases, undergo malignant transformation.
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
Diagnostic Techniques and Procedures
Monomeric GTP-Binding Proteins
A class of monomeric, low molecular weight (20-25 kDa) GTP-binding proteins that regulate a variety of intracellular processes. The GTP bound form of the protein is active and limited by its inherent GTPase activity, which is controlled by an array of GTPase activators, GDP dissociation inhibitors, and guanine nucleotide exchange factors. This enzyme was formerly listed as EC 188.8.131.52
rho GTP-Binding Proteins
rhoA GTP-Binding Protein
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 184.108.40.206.
Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation. (1/364)The c-myb gene encodes a sequence specific transactivator that is required for fetal hematopoiesis, but its potential role in other tissues is less clear because of the early fetal demise of mice with targeted deletions of the c-myb gene and incomplete of knowledge about c-myb's expression pattern. In the hematopoietic system, c-Myb protein acts on target genes whose expression is restricted to individual lineages, despite Myb's presence and role in multiple immature lineages. This suggests that c-Myb actions within different cell type-specific contexts are strongly affected by combinatorial interactions. To consider the possibility of similar c-Myb actions could extend into non-hematopoietic systems in other cell and tissue compartments, we characterized c-myb expression in developing and adult mice using in situ hybridization and correlated this with stage-specific differentiation and mitotic activity. Diverse tissues exhibited strong c-myb expression during development, notably tooth buds, the thyroid primordium, developing trachea and proximal branching airway epithelium, hair follicles, hematopoietic cells, and gastrointestinal crypt epithelial cells. The latter three of these all maintained high expression into adulthood, but with characteristic restriction to immature cell lineages prior to their terminal differentiation. In all sites, during fetal and adult stages, loss of c-Myb expression correlated strikingly with the initiation of terminal differentiation, but not the loss of mitotic activity. Based on these data, we hypothesize that c-Myb's function during cellular differentiation is both an activator of immature gene expression and a suppressor of terminal differentiation in diverse lineages. (+info)
Pathological evaluation of the effects of intentional disocclusion and overloading occlusion in odontogenesis disorders in N-methylnitrosourea-treated hamsters. (2/364)This study compares the effects of disocclusion and overloading occlusion on dental lesions. Ten-day-old Syrian hamsters were divided into 4 groups: group I, untreated animals; group II, animals whose hemilateral incisors were disoccluded; group III, N-methylnitrosourea (MNU)-treated animals; and group IV, MNU-treated animals whose hemilateral incisors were disoccluded. The ipsilateral maxillary and mandibular incisors were repetitively cut with diamond discs. The hamster is easier to anesthetize. Animals received a 0.2% solution of MNU (10 mg/kg body weight) intragastrically twice a week for 16 wk. All the cut mandibular incisors and the MNU-treated uncut mandibular incisors showed lack of iron deposition on the enamel surface. The eruption rate was significantly higher in the cut disoccluded incisors of groups II and IV (p < 0.05) and significantly lower in the uncut overloaded incisors of groups II and IV (p < 0.05). In the cut mandibular incisors of group IV, the degree of the disturbance of odontogenesis and the atypical proliferation of odontogenic epithelium were more prominent (p < 0.02), and the dental lesions occurred earlier. Histologically, the disturbed Hertwig's epithelial sheath and the Hertwig's epithelial sheath-like transformed U-shaped part and enamel organ seemed to lead to disturbances of amelogenesis and detinogenesis as well as to atypical proliferation of odontogenic epithelium nests. Thus, this method of disocclusion of the incisors of rodents may represent a useful model for the investigation of the effects of various agents on tooth formation over a short experimental period. (+info)
Immunohistological distributions of fibronectin, tenascin, type I, III and IV collagens, and laminin during tooth development and degeneration in fetuses of minke whale, Balaenoptera acutorostrata. (3/364)The immunohistological distributions of fibronectin, tenascin, type I, III and IV collagens, and laminin were observed in the tooth buds of fetuses of minke whale, Balaenoptera acutorostrata. Distributions of extracellular matrices (ECMs) examined in this study except for tenascin were generally similar to those of terrestrial mammalian species during development of the tooth bud. Tenascin in the fetuses of minke whale showed characteristic distributions in the dental lamina and the enamel organ in the early tooth developmental stage. In the physiological degeneration stage of tooth bud development, immunoreactivity of the ECMs were very weakly and limitedly detected in the dental papilla and the surrounding mesenchyme. Immunoreactivity of tenascin and type I and III collagens were positively detected in the developing baleen plate germ which was associated with the degenerating tooth bud. These findings suggested that expressions of the ECMs were related to the formation of the tooth bud and baleen plate germ, and that the lack of the ECMs was related to the degeneration of the tooth bud in the fetal minke whale. (+info)
Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. (4/364)Osteoblasts and odontoblasts, cells that are responsible for the formation of bone and dentin matrices respectively, share several molecular characteristics. Recently, Cbfa1 was shown to be a critical transcriptional regulator of osteoblast differentiation. Mutations in this gene cause cleidocranial dysplasia (CCD), an autosomal dominant disorder in humans and mice characterized by defective bone formation. CCD also results in dental defects that include supernumerary teeth and delayed eruption of permanent dentition. The dental abnormalities in CCD suggest an important role for this molecule in the formation of dentition. Here we describe results of studies aimed at understanding the functions of Cbfa1 in tooth formation. RT-PCR and in situ hybridization analyses show that Cbfa1 has a unique expression pattern in dental mesenchyme from the bud to early bell stages during active epithelial morphogenesis. Unlike that observed in osteoblast differentiation, Cbfa1 is downregulated in fully differentiated odontoblasts and is surprisingly expressed in ectodermally derived ameloblasts during the maturation phase of enamel formation. The role of Cbfa1 in tooth morphogenesis is further illustrated by the misshapen and severely hypoplastic tooth organs in Cbfa1-/- mice. These tooth organs lacked overt odontoblast and ameloblast differentiation and normal dentin and enamel matrices. Epithelial-mesenchymal recombinants demonstrate that dental epithelium regulates mesenchymal Cbfa1 expression during the bud and cap stages and that these effects are mimicked by the FGFs but not by the BMPs as shown by our bead implantation assays. We propose that Cbfa1 regulates the expression of molecules in mesenchyme that act reciprocally on dental epithelium to control its growth and differentiation. Taken together, our data indicate a non-redundant role for Cbfa1 in tooth development that may be distinct from that in bone formation. In odontogenesis, Cbfa1 is not involved in the early signaling networks regulating tooth initiation and early morphogenesis but regulates key epithelial-mesenchymal interactions that control advancing morphogenesis and histodifferentiation of the epithelial enamel organ. (+info)
The heritability of malocclusion: Part 1--Genetics, principles and terminology. (5/364)The relative contribution of genes and the environment to the aetiology of malocclusion has been a matter of controversy throughout the twentieth century. Genetic mechanisms are clearly predominant during embryonic craniofacial morphogenesis, but environment is also thought to influence dentofacial morphology postnatally, particularly during facial growth. Orthodontic and orthopaedic techniques are used in the treatment of malocclusion and other dentofacial deformities, but with limited effectiveness. The key to the determination of the aetiology of malocclusion, and its treatability lies in the ability to differentiate the effect of genes and environment on the craniofacial skeleton in a particular individual. Our ability to do this is limited by our lack of knowledge on the genetic mechanisms that control facial growth and lack of scientific evidence for the influence of environmental factors on human craniofacial morphogenesis. (+info)
Nerve growth factor (NGF) supports tooth morphogenesis in mouse first branchial arch explants. (6/364)Posterior midbrain and anterior hindbrain neuroectoderm trans-differentiate into cranial neural crest cells (CNCC), emigrate from the neural folds, and become crest-derived ectomesenchyme within the mandibular and maxillary processes. To investigate the growth factor requirement specific for the initiation of tooth morphogenesis, we designed studies to test whether nerve growth factor (NGF) can support odontogenesis in a first branchial arch (FBA) explant culture system. FBA explants containing neural-fold tissues before CNCC emigration and the anlagen of the FBA were microdissected from embryonic day 8 (E8) mouse embryos, and cultured for 8 days in medium supplemented with 10% fetal calf serum only, or serum-containing medium further supplemented with either NGF or epidermal growth factor (EGF) at three different concentrations: 50, 100, or 200 ng/ml. Morphological, morphometric, and total protein analyses indicated that growth and development in all groups were comparable. Meckel's cartilage and tongue formation were also observed in all groups. However, odontogenesis was only detected in explants cultured in the presence of exogenous NGF. NGF-supplemented cultures were permissive for bud stage (50 ng/ml) as well as cap stage of tooth morphogenesis (100 and 200 ng/ml). Morphometric analyses of the volume of tooth organs showed a significant dose-dependent increase in tooth volume as the concentration of NGF increased. Whole-mount in situ hybridization and semiquantitative reverse transcription-polymerase chain reaction for Pax9, a molecular marker of dental mesenchyme, further supported and confirmed the morphological data of the specificity and dose dependency of NGF on odontogenesis. We conclude that (1) E8 FBA explants contain premigratory CNCC that are capable of emigration, proliferation, and differentiation in vitro; (2) serum-supplemented medium is permissive for CNCC differentiation into tongue myoblasts and chondrocytes in FBA explants; and (3) NGF controls CNCC cell fate specification and differentiation into tooth organs. (+info)
Alterations in the incisor development in the Tabby mouse. (7/364)The X-linked tabby (Ta) syndrome in the mouse is homologous to the hypohidrotic ectodermal dysplasia (HED) in humans. As in humans with HED, Ta mice exhibit hypohidrosis, characteristic defects of hairs and tooth abnormalities. To analyze the effects of Ta mutation on lower incisor development, histology, morphometry and computer-aided 3D reconstructions were combined. We observed that Ta mutation had major consequences for incisor development leading to abnormal tooth size and shape, change in the balance between prospective crown- and root-analog tissues and retarded cytodifferentiations. The decrease in size of Ta incisor was observed at ED13.5 and mainly involved the width of the tooth bud. At ED14.5-15.5, the incisor appeared shorter and narrower in the Ta than in the wild type (WT). Growth alterations affected the diameter to a greater extent than the length of the Ta incisor. From ED14.5, changes in the shape interfered with the medio-lateral asymmetry and alterations in the posterior growth of the cervical loop led to a loss of the labio-lingual asymmetry until ED17.0. Although the enamel organ in Ta incisors was smaller than in the WT, a larger proportion of the dental papilla was covered by preameloblasts-ameloblasts. These changes apparently resulted from reduced development of the lingual part of the enamel organ and might be correlated with a possible heterogeneity in the development of the enamel organ, as demonstrated for upper incisors. Our observations suggest independent development of the labial and lingual parts of the cervical loop. Furthermore, it appeared that the consequences of Ta mutation could not be interpreted only as a delay in tooth development. (+info)
Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage. (8/364)Members of the Pitx/RIEG family of homeodomain-containing transcription factors have been implicated in vertebrate organogenesis. In this study, we examined the expression and regulation of Pitx1 and Pitx2 during mouse tooth development. Pitx1 expression is detected in early development in a widespread pattern, in both epithelium and mesenchyme, covering the tooth-forming region in the mandible, and is then maintained in the dental epithelium from the bud stage to the late bell stage. Pitx2 expression, on the other hand, is restricted to the dental epithelium throughout odontogenesis. Interestingly, from E9.5 to E10.5, the expression domains of Pitx1 and Pitx2, in the developing mandible, overlap with that of Fgf8 but are exclusive to the zone of Bmp4 expression. Bead implantation experiments demonstrate that ectopic expression of Fgf8 can induce/maintain the expression of both Pitx1 and Pitx2 at E9.5. In contrast, Bmp4-expressing tissues and BMP4-soaked beads were able to repress Pitx1 expression in mandibular mesenchyme and Pitx2 expression in the presumptive dental epithelium, respectively. However, the effects of FGF8 and BMP4 are transient. It thus appears that the early expression patterns of Pitx1 and Pitx2 in the developing mandible are regulated by the antagonistic effects of FGF8 and BMP4 such that the Pitx1 and Pitx2 expression patterns are defined. These results indicate that the epithelial-derived signaling molecules are responsible not only for restricting specific gene expression in the dental mesenchyme, but also for defining gene expression in the dental epithelium. (+info)
Odontogenesis | Profiles RNS
The process of TOOTH formation. It is divided into several stages including: the dental lamina stage, the bud stage, the cap stage, and the bell stage. Odontogenesis includes the production of tooth enamel (AMELOGENESIS), dentin (DENTINOGENESIS), and dental cementum (CEMENTOGENESIS ...
odontogenesis of dentin-containing tooth | Semantic Scholar
The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. [GOC:cjm, GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794]
Gene expression in tooth: references
We have studied the expression of transforming growth factor beta-1 (TGF-beta 1) RNA during mouse tooth development, using in situ hybridization and experimental tissue recombinations. Analysis of the serial sections revealed the appearance of local expression of TGF-beta 1 RNA in the dental epithelium at bud- staged teeth (13-day embryos). Just before transition to the cap stage, TGF-beta 1 RNA expression rapidly increased in the epithelial bud, and it also extended to the condensed dental mesenchyme. At cap stage (14- and 15-day embryos), there was an intense expression of TGF-beta 1 RNA in the morphologically active cervical loops of the dental epithelium. During early bell stage (16- and 17-day embryos), TGF-beta 1 RNA expression was detected in the inner enamel epithelium where it subsequently almost disappeared (18- day embryos). After birth TGF-beta 1 transcripts transiently appeared in these cells when they were differentiating into ameloblasts (1-day mice). The transcripts were lost ...
Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape |...
We have studied the expression patterns of the newly isolated homeobox gene, Hox-8 by in situ hybridisation to sections of the developing heads of mouse embryos between E9 and E17.5, and compared them to Hox-7 expression patterns in adjacent sections. This paper concentrates on the interesting expression patterns of Hox-8 during initiation and development of the molar and incisor teeth. Hox-8 expression domains are present in the neural crest-derived mesenchyme beneath sites of future tooth formation, in a proximo-distal gradient. Tooth development is initiated in the oral epithelium which subsequently thickens in discrete sites and invaginates to form the dental lamina. Hox-8 expression in mouse oral epithelium is first evident at the sites of the dental placodes, suggesting a role in the specification of tooth position. Subsequently, in molar teeth, this patch of Hox-8 expressing epithelium becomes incorporated within the buccal aspect of the invaginating dental lamina to form part of the ...
The Biological way of How our Teeth Develop - Smith and Van Lierop Dentistry
Tooth development or odontogenesis is the complex process by which tooth form from embryonic cells,grow, and erupt into the mouth. For human teeth to have a healthy oral environment, all parts of the tooth must develop during appropriate stages of fetal development. Primary (baby) teeth start to form between the sixth and eighth week of prenatal development, and permanent teeth begin to form in the twentieth week. If teeth do not start to develop at or near these times, they will not develop at all, resulting in Hypodontia or Anodontia.. Tooth development is commonly divided into the following stages: the initiation stage, the bud stage, the cap stage, the bell stage, and finally maturation.. Initiation Stage. One of the earliest signs in the formation of a tooth that can be seen microscopically is the distinction between the vestibular lamina and the dental lamina. The dental lamina connects the developing tooth bud to the epithelial layer of the mouth for a significant time. This is regarded ...
inner enamel epithelium
The bell stage is known for the histodifferentiation and morphodifferentiation that takes place. The dental organ is bell-shaped during this stage, and the majority of its cells are called stellate reticulum because of their star-shaped appearance.. THE BELL STAGE IS DIVIDED INTO EARLY BELL STAGE & LATE BELL STAGES. Continue reading →. ...
EX1; Practical Images - Face Development and Odontogenesis Flashcards by Courtney Kast | Brainscape
Study EX1; Practical Images - Face Development and Odontogenesis flashcards from Courtney Kast's The Ohio State University College of Dentistry. class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
Dog Abnormal Molar Development - Abnormal Molar Development in Dogs | petMD
The abnormal development and formation of the mandibular tooth, a molar located three teeth away from the midline of the jaw, is an oral health issue seen primarily in small breed dogs.
Mouse Tooth Development Movie - Embryology
Time-lapse imaging of a developing tooth germ derived from a transgenic mouse embryo (E 12.5-13.5). Co-expressing Fucci-G0/G1 probe and H2BEGFP. The tooth germ was cultured for 5 days ex vivo, and the images were taken at 30-min intervals. The lingual side is on the left. Tooth morphogenetic dynamics viewed by an ex vivo time-lapse imaging system using transgenic mouse embryos co-expressing the Fucci-G0/G1 probe (Cdt1-mKO) and enhanced green fluorescent protein-labeled human histone 2B (H2B-EGFP). ...
Tooth Development in Human Evolution and Bioarchaeology
A new volume by Simon Hillson on Tooth Development in Human Evolution and Bioarchaeology has just been published by Cambridge University Press.. Human children grow at a uniquely slow pace by comparison with other mammals. When and where did this schedule evolve? Have technological advances, farming and cities had any effect upon it? Addressing these and other key questions in palaeoanthropology and bioarchaeology, Simon examines the unique role of teeth in preserving detailed microscopic records of development throughout childhood and into adulthood. The volume critically reviews theory, assumptions, methods and literature, providing the dental histology background to anthropological studies of both growth rate and growth disruption. Chapters also examine existing studies of growth rate in the context of human evolution and primate development more generally, together with implications for life history. The final chapters consider how defects in the tooth development sequence shed light on the ...
Gene Expression Literature Detail
J:83512 Hikake T, Mori T, Iseki K, Hagino S, Zhang Y, Takagi H, Yokoya S, Wanaka A, Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development. Anat Embryol (Berl). 2003 Apr;206(5):373-80 ...
Gene expression in tooth: references
Vertebrate organogenesis is initiated at sites that are often morphologically indistinguishable from the surrounding region. Here we have identified Pax9 as a marker for prospective tooth mesenchyme prior to the first morphological manifestation of odontogenesis. We provide evidence that the sites of Pax9 expression in the mandibular arch are positioned by the combined activity of two signals, one (FGF8) that induces Pax9 expression and the other (BMP2 and BMP4) that prevents this induction. Thus it appears that the position of the teeth is determined by a combination of two different types of signaling molecules produced in wide but overlapping domains rather than by a single localized inducer. We suggest that a similar mechanism may be used for specifying the sites of development of other organs. ...
Teeth Germ Scanner Simulator for Android
Download Teeth Germ Scanner Simulator. Teeth Germ Scanner Prank is a simulator of scanning teeth germs for entertainment! Find out what type bacteria or germs live on teeth on phone screen! Play Teeth Bacteria Scanner Prank app direct your...
ICD-9 Code 520.9 -Unspecified disorder of tooth development and eruption- Codify by AAPC
ICD-9 code 520.9 for Unspecified disorder of tooth development and eruption is a medical classification as listed by WHO under the range - DISEASES OF
Download Modern pharmacology with clinical applications by Craig C.R., Stitzel R.E. (eds.) PDF - MFV3D Book Archive
Conversely, a decrease in gastrointestinal motility may promote absorption by increasing contact time. Thus, the effect depends on the drug and change in motility. Serious intestinal diseases, particularly those associated with intestinal sloughing, can be expected to alter drug absorption dramatically. Food Absorption of most drugs from the gastrointestinal tract is reduced or delayed by the presence of food in the gut. Drugs such as the tetracyclines, which are highly ionized, can complex with Caϩϩ ions in membranes, food, or milk, leading to a reduction in their rate of absorption. Tetracycline deposition during odontogenesis may lead to a permanent yellow-brown discoloration of teeth, dysplasia, and poor bone development. Lead can substitute for calcium in the bone crystal lattice, resulting in bone brittleness. Bone may become a reservoir for the slow release of toxic substances, such as lead and cisplatin. PHYSIOLOGICAL BARRIERS TO DRUG DISTRIBUTION Blood-Brain Barrier The capillary ...
Gene Expression Literature Detail
J:56622 Sarkar L, Sharpe PT, Expression of Wnt signalling pathway genes during tooth development. Mech Dev. 1999 Jul;85(1-2):197-200 ...
Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis | PNAS
The transcription factor Ctip2/Bcl11b plays essential roles in developmental processes of the immune and central nervous systems and skin. Here we show that Ctip2 also plays a key role in tooth development. Ctip2 is highly expressed in the ectodermal components of the developing tooth, including inner and outer enamel epithelia, stellate reticulum, stratum intermedium, and the ameloblast cell lineage. In Ctip2−/− mice, tooth morphogenesis appeared to proceed normally through the cap stage but developed multiple defects at the bell stage. Mutant incisors and molars were reduced in size and exhibited hypoplasticity of the stellate reticulum. An ameloblast-like cell population developed ectopically on the lingual aspect of mutant lower incisors, and the morphology, polarization, and adhesion properties of ameloblasts on the labial side of these teeth were severely disrupted. Perturbations of gene expression were also observed in the mandible of Ctip2−/− mice: expression of the ameloblast ...
Tooth buds | definition of tooth buds by Medical dictionary
Looking for online definition of tooth buds in the Medical Dictionary? tooth buds explanation free. What is tooth buds? Meaning of tooth buds medical term. What does tooth buds mean?
Epiprofin/Sp6: A new player in the regulation of tooth development - Infoscience
Odontogenesis is governed by a complex network of intercellular signaling events between the dental epithelium and mesenchyme. This network leads to the progressive determination of tooth shape, and to the differentiation of these tissues into enamel-producing ameloblasts and dentin-producing odontoblasts respectively. Among the main signaling pathways involved in the regulation of tooth development, Bone Morphogenetic Protein (BMP), Sonic hedgehog (Shh) and Wingless-type MMTV integration site (Wnt) pathways have been reported to play significant roles. Recently, the phenotype of mice deficient in Epiprofin/Sp6 (Epfn) has been found to present striking dental abnormalities, including a complete lack of differentiated ameloblasts and consequently no enamel, highly altered molar cusp patterns and the formation of multiple supernumerary teeth. In this article, we review the interaction of Epfn with the BMP, Shh and Wnt pathways in the regulation of tooth development, based on the data obtained from the
Cell cycle of the enamel knot during tooth morphogenesis<...
TY - JOUR. T1 - Cell cycle of the enamel knot during tooth morphogenesis. AU - Jung, Seo Yoon. AU - Green, David William. AU - Jung, Han Sung. AU - Kim, Eun Jung. N1 - Funding Information: Acknowledgements We are grateful to Chengri Li for helping experiments. This study was supported by the Yonsei University College of Dentistry (6-2016-0021).. PY - 2018/6/1. Y1 - 2018/6/1. N2 - Enamel knot (EK) is known to be a central organ in tooth development, especially for cusp patterning. To trace the exact position and movement among the inner dental epithelium (IDE) and EK cells, and to monitor the relationship between the EK and cusp patterning, it is essential that we understand the cell cycle status of the EK in early stages of tooth development. In this study, thymidine analogous (IdU, BrdU) staining was used to evaluate the cell cycle phase of the primary EK at the early casp stage (E13.0) and the gerbil embryo (E19) in a developing mouse embryo. The centerpiece of this study was to describe the ...
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Four Ways to Reduce Early Tooth Decay in Kids
Early tooth decay is damage on the tooths enamel, and can happen anywhere on the tooth, and at any age. The good news is that its very treatable.
Most recent papers with the keyword tooth germ | Read by QxMD
Homeobox protein MSX-1 (hereafter referred to as MSX-1) is essential for early tooth-germ development. Tooth-germ development is arrested at bud stage in Msx1 knockout mice, which prompted us to study the functions of MSX-1 beyond this stage. Here, we investigated the roles of MSX-1 during late bell stage. Mesenchymal cells of the mandibular first molar were isolated from mice at embryonic day (E)17.5 and cultured in vitro. We determined the expression levels of β-catenin, bone morphogenetic protein 2 (Bmp2), Bmp4, and lymphoid enhancer-binding factor 1 (Lef1) after knockdown or overexpression of Msx1 ...
Services - SmilePlus Homestead
Depending on the health and oral hygiene of the patient, implants could be a success or a failure. However, implants have an immense success rate and can last up to 15 years. Patients who are missing teeth and desire healthier hygiene in their mouth chose to have an implant. Implants are replacement tooth roots, made of metal that are placed into the bone socket where teeth are missing. It functions as a natural tooth, promotes better hygiene, stimulates the bone, and preserves the right masticatory function. Once the implant is placed, a crown is placed, covering the replacement tooth. Implants can be painful, expensive, and take a long period of time but the result at the end of the procedure is excellent.. We are now able to provide our patients the latest on implant tech- nology. A system called FlatOne Abutment. This system will not only reduce costs to patients but also guarantees a full-arch fixed tempo- rary prosthesis in as little as 48 hours, and in some cases the very same day the ...
Welcome to The Visible Embryo
The tooth is an ectodermal organ that arises from a tooth germ under the regulation of reciprocal epithelial-mesenchymal interactions. Tooth morphogenesis occurs in the tooth-forming field as a result of reaction-diffusion waves of specific gene expression patterns. Here, we developed a novel mechanical ligation method for splitting tooth germs to artificially regulate the molecules that control tooth morphology. The split tooth germs successfully developed into multiple correct teeth through the re-regionalisation of the tooth-forming field, which is regulated by reaction-diffusion waves in response to mechanical force. Furthermore, split teeth erupted into the oral cavity and restored physiological tooth function, including mastication, periodontal ligament function and responsiveness to noxious stimuli. Thus, this study presents a novel tooth regenerative technology based on split tooth germs and the re-regionalisation of the tooth-forming field by artificial mechanical force ...
ModuleWorks shows latest Dental developments at IDS
ModuleWorks shows latest Dental developments at IDS: Feb 12, 2015 -- At the International Dental Show in March, ModuleWorks will be showing all the latest developments in the ModuleWorks Dental product range. Originally launched back in 2009, the product aims to bring the benefits of hundreds of man-years of toolpath development technology from the CAM market to the Dental market. And in the two years since the previous IDS show, this technology has enabled many new toolpath …
Scholarly Commons - Research Day: PAX9 GENE POLYMORPHISMS AND MISSING TEETH
It was shown in both mouse and human tooth development that PAX9 and MSX1 are the most important genes regulating progression through early stages of tooth development. These genes are encoding transcription factors involved in epithelial/mesenchymal interactions. Their key function seems to be maintenance and regulation of Bmp4 expression in dental mesenchyme. If the functions of PAX9 and MSX1 are disturbed, the tooth will not develop.
Missing baby lower incisor tooth
Hello My (almost) 3yo son is missing baby lower incisor tooth. Is this something I should be looking to take action on now or wait and see if a permanent
JCDR - Bioengineering, Odontogenesis, Regeneration, Stem cells
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
Association of developmental regulatory genes with the development of different molar tooth shapes in two species of rodents |...
While the evolutionary history of mammalian tooth shapes is well documented in the fossil record, the developmental basis of their tooth shape evolution is unknown. We investigated the expression pat
So, you lost a tooth. Dont despair! If you dont have the bucks to have a dentist install an implant or a bridge right now, you can replace the tooth yourself. Youll have to have one tooth on each side of the missing tooth for this procedure to work. If thats the case, you can replace your missing tooth in less than an hour. This is not to suggest that you can or should be your own dentist in all situations, or that a replacement tooth made by you will last as long as one made by Read more [...] ...
Fly-like Gene Linked To Tooth Development and Glaucoma | EurekAlert! Science News
In a study supported by the National Institutes of Health, scientists at the University of Iowa have just identified the gene that causes Rieger syndrome, a rare disorder that leads to glaucoma in 50 percent of the cases
Dental Bridges - What can they do for You? | HubPages
A dental bridge is a way of replacing one or more missing teeth by permanently fixing the replacement tooth to one or more of your own standing teeth. As with most things, theres more than one way of doing this and each comes with its own pros...
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Dental implants give you replacement teeth that look and feel like real ones, without the drawbacks so often associated with older traditional full-tooth
Initial features of the inner dental epithelium histo-morphogenesis in the first lower molar in mouse - Institut de Génomique...
H. Lesot, R. Peterkova, R. Schmitt, J. M Meyer, L. Viriot, J. L Vonesch, B. Senger, M. Peterka, and J. V Ruch (1999) Int J Dev Biol, 43(3):245-54.. ...
The care of Paediatric teeth begins as soon as your child has developed baby teeth. We provide the guidance and treatment for childrens dental development.
TOOTH GERM: So what happens after DFT...?
There are agencies you can register with to help you find a job, but make sure you start your visa applications early and contact each countrys regulator in case you need to take entrance exams and if they recognise your dental qualification. Some countries such as the USA and Canada do not recognise the UK Bachelor of Dental Surgery (BDS) and you will have to undergo further training if you wish to practise in these countries. ...
10 - 12 years physical and sexual development - Kidspot
At this stage, your childs body, regardless of sex, will begin to change shape and mature. Whether shes an early or late bloomer, change is inevitable and will commence in its own time - like tooth development, it cannot be hurried or slowed.
TOOTH GERM: I Amsterdam: City Break
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Parts Of The Integumentary System - Anatomy
Integumentary System Parts Of The Integumentary System Integumentary System Functions Parts Of The Integumentary System, Parts Of The Integumentary System The Integumentary System Ch 5 Objectives Identify Various Parts, Structures Of The Integumentary System Lessons Tes Teach Parts Of The Integumentary System, Integumentary System Parts Of The Integumentary System, ...
Alligator Stem Cells Offer Hope for Tooth Regeneration in Humans
Posted on 05/18/2013 2:08:28 PM PDT by LibWhacker. An international team of scientists led by Prof Cheng-Ming Chuong from the University of Southern California has discovered unique cellular and molecular mechanisms behind tooth renewal in American alligators (Alligator mississippiensis).. Their findings, published in the Proceedings of the National Academy of Sciences, pave the way for tooth regeneration in people. Humans naturally only have two sets of teeth baby teeth and adult teeth. Ultimately, we want to identify stem cells that can be used as a resource to stimulate tooth renewal in adult humans who have lost teeth. But, to do that, we must first understand how they renew in other animals and why they stop in people, Prof Chuong said. Whereas most vertebrates can replace teeth throughout their lives, human teeth are naturally replaced only once, despite the lingering presence of a band of epithelial tissue called the dental lamina, which is crucial to tooth development. Because alligators ...
Lateral periodontal cyst - Wikipedia
The lateral periodontal cyst is a non-inflammatory developmental cyst that arises from the epithelial post-functional dental lamina, which is a remnant from odontogenesis. It is more common in middle-aged males. Usually asymptomatic, it presents as a regular well-corticated radiolucency on the side of a mandibular canine or premolar root. Histologically, the cyst appears similar to the gingival cyst of the adult, having a non-keratinized squamous epithelial lining. The involved tooth is usually vital and has no indication for root canal treatment unless the signs of non-vital or necrotic pulpal tissue were confirmed. The cysts arise from epithelial rest cells in the periodontal ligament, although it is unknown whether from the cell rests of Malassez, reduced enamel epithelium or dental lamina remnants, and are generally treated by surgical enucleation. Altini M, Shear M. The lateral periodontal cyst: an update. J Oral Pathol Med. 1992 Jul; 21(6):245-50. Wood K, Goaz P. 5th ed. St. Louis: Mosby; ...
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Abnormal Molar Development in Dogs
Your veterinarian will perform a thorough physical and oral exam on your dog, taking into account the background history of symptoms, if there have been any. Dens-in-dente, an anomaly of development resulting from the deepening of enamel into the dental papilla (the cells involved in the developing tooth), typically begins at the crown and often extends to the root before the calcification of the dental tissues takes place. Traumatic damage to the tooth, possibly from aggressive deciduous tooth (i.e., baby tooth) extraction, may be linked to a loss of dental integrity.. If your veterinarian finds that the tooth is too damaged to remain, an assessment of the remaining mandibular bone will be an important prior to an extraction attempt. The diagnostic evaluation will include taking a dental X-ray to evaluate the extent of the changes, particularly at the roots.. ...
Tooth germ | definition of tooth germ by Medical dictionary
Looking for online definition of tooth germ in the Medical Dictionary? tooth germ explanation free. What is tooth germ? Meaning of tooth germ medical term. What does tooth germ mean?
Unilateral Connation of Permanent Mandibular Incisors: A Case Report | MedCrave
Connated teeth are the consequences of developmental anomalies leading to the eruption of joined elements. Fusion and gemination are terms frequently used to describe the clinical presentation of connated teeth. The terms double teeth, double formations, joined teeth, fused teeth or dental twinning are often used to describe fusion or gemination, both of which are primary developmental abnormalities of the teeth. It is caused by the persistence of the dental lamina between two or more tooth germs, or by the attempt of a supernumerary tooth to develop from the remnants of the dental lamina after it has divided from a neighbouring tooth germ . There are different clinical and radiographic appearances for connated teeth reliant on the developmental stages of the bud . It is hypothesised that, forces or pressure can produce the contact between the teeth. Depending upon the stage of development, the union may be total or partial and may occur between a normal and a supernumerary tooth ...
Incisor - wikidoc
The rodent incisor is one of the evolutionary adaptations that make rodents such a successful group. There are two incisors in the upper jaw and two in the lower jaw. The incisors are separated from the molars by a diastema region, an area without any teeth. The tissue of the incisor is regenerated from the apical end and constantly wears down at the distal tip. The ever-growing incisor can be subdivided into two areas, the crown analogue and the root analogue. The crown analogue is the labial half of the incisor. It is characterized by an enlarged cervical loop at the apical end. The cervical loop is the epithelial stem cell niche. The epithelial progeny of the crown analogues cervical loop differentiates into ameloblasts that produce enamel. The root analogue is the lingual half of the incisor. Its cervical loop is much smaller and the epithelium does not differentiate into ameloblasts, but instead forms a root sheath and fragments into epithelial cell rests of Malassez typical of root ...
Integumentary system financial definition of integumentary system
Definition of integumentary system in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is integumentary system? Meaning of integumentary system as a finance term. What does integumentary system mean in finance?
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Transgenic analysis of Dlx regulation in fish tooth development reveals evolutionary retention of enhancer function despite...
Transgenic analysis of Dlx regulation in fish tooth development reveals evolutionary retention of enhancer function despite organ loss Journal Article ...
Yellow stained teeth in children and Abnormal tooth shape in children - Symptom Checker - check medical symptoms at...
List of causes of Yellow stained teeth in children and Abnormal tooth shape in children, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
Janne Elin Reseland - Institutt for klinisk odontologi
Skalleberg, Natalie Sharim; Xianbin, Yang; Babaie, Eshrat; Crystal, John Michael; Geronimo, Benedicto Abrigos; Reseland, Janne Elin; Osmundsen, Harald & Landin, Maria Augusta Dos S Silva (2018). Effects of miR-214 knockout on 214/199 cluster expression levels during mineralization of the first murine molar. PLoS biology. ISSN 1544-9173. Vis sammendrag The objectives of this study were to investigate the effects induced on the 214/199 cluster and consequently murine miRNome while miR-214 was temporarily knocked out on the first murine molar. Endogenous expression of individual microRNAs (miRNAs) of 214/199 cluster during mineralization stages was also mapped. Nucleotide alignment of miR-214 mature sequence and comparative genomics was used to find target genes for this miR during mineralization of the first murine molar. The effects of temporary knockdown of miR-214 were induced by in vivo transfection with antagomir-214 in situ at the first murine molar. The expression levels of microRNAs (miRs) ...
Fate of HERS during tooth root development. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
7.04 Muscular Skeletal and Integumentary Systems.rtf - Biology Notebook 07.04 Muscular Skeletal and Integumentary Objectives...
View 7.04 Muscular Skeletal and Integumentary Systems.rtf from BIOLOGY COVID at University of Notre Dame. Biology Notebook: 07.04 Muscular, Skeletal, and Integumentary Objectives: Describe the
The Root Canal Anatomy Project: February 2012
Mandibular molars can have an additional root located lingually (the radix entomolaris) or buccally (the radix paramolaris). The presence of a separate RE in the first mandibular molar is associated with certain ethnic groups. In African populations a maximum frequency of 3% is found, while in Eurasian and Indian populations the frequency is less than 5%. In populations with Mongoloid traits (such as the Chinese, Eskimo and American Indians) reports have noted that the RE occurs with a frequency that ranges from 5% to more than 30%. Because of its high frequency in these populations, the RE is considered to be a normal morphological variant (eumorphic root morphology). In Caucasians the RE is not very common and, with a maximum frequency of 3.4 to 4.2%, is considered to be an unusual or dysmorphic root morphology. The etiology behind the formation of the RE is still unclear. In dysmorphic, supernumerary roots, its formation could be related to external factors during odontogenesis, or to ...
Third molars stage of mineralization and its relation to chronological age: Midwest Brazil sample
MATERIAL AND METHOD:. This cross-sectional observational study comprised a total of 120 panoramic radiographies of patients aged 5-22 year-old, males and females, attended between 2007 and 2012 at our Institution. The third molars development stage was analyzed based on the method described by Nolla and related with the chronological age of the individual by linear regression. It was considered significant values for linear tendency between 0-1. ...
Tissue interactions in the regulation of axon pathfinding during tooth morphogenesis
Like many other organs, the tooth develops as a result of the epithelial-mesenchymal interactions. In addition, the tooth is a well-defined peripheral target organ for sensory trigeminal nerves, which are required for the function and protection of the teeth. Dental trigeminal axon growth and patter …
Lower Jaw Incisors Teeth Open On Top - Hello Myself | Practo Consult
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Dental Development - baby, swollen, symptoms, stages, Definition, Description, Common problems
Abscess -A localized collection of pus in the skin or other body tissue caused by infection. Bicuspid -Premolar; the two-cupped tooth between the first molar and the cuspid. Calcification -A process in which tissue becomes hardened due to calcium deposits. Calculus -Plural, calculi. Any type of hard concretion (stone) in the body, but usually found in the gallbladder, pancreas, and kidneys. They are formed by the accumulation of excess mineral salts and other organic material such as blood or mucus. Calculi (pl.) can cause problems by lodging in and obstructing the proper flow of fluids, such as bile to the intestines or urine to the bladder. In dentistry, calculus refers to a hardened yellow or brown mineral deposit from unremoved plaque, also called tartar. Canines -The two sharp teeth located next to the front incisor teeth in mammals that are used to grip and tear. Also called cuspids. Crown -The natural part of the tooth covered by enamel. A restorative crown is a protective shell that fits ...
Dental papilla analysis: a multifactorial viewpoint :: University of Southern California Dissertations and Theses
Full papillae serve both esthetic and functional roles. Black triangles have perplexed clinicians by interrupting the harmony of the smile. Several studies in the past have attempted to understand the appearance of black triangles. Bone to contact distance is the most discussed factor involved in black triangle appearance, but there seems to be countless others. Newer research has focused on systemic as well as local anatomical factors such as age, interdental width, and tissue thickness. The aim of this study was to evaluate papilla fullness with regards to bone to contact distance, interdental width, periodontal biotype, tooth type, and age. ❧ 333 papillae from 50 patients of the dental hygiene department of the Herman Ostrow School of Dentistry of the University of Southern California were examined. The age of each patient was recorded. After adequate anesthesia, each sextant was examined for papilla fullness. Periodontal sounding was used to measure both the bone to contact distance and ...
Integumentary System Answer Key - PDF
Answer Key Free PDF ebook Download: Answer Key Download or Read Online ebook integumentary system answer key in PDF Format From The Best User Guide Database the major organs and functions of the integumentary
PPT - The Integumentary System PowerPoint Presentation - ID:2327672
The Integumentary System. / biology/Wags/ histopage/colorpage/cin/ cin.htmhttp://www.udel.edu. Picture From: http://www.myyogaonline.com/healthy-living/natural-beauty/structure-function-and-care-of-human-skin. The Integumentary System. Slideshow 2327672 by arlo
KAKEN - Research Projects | Phylogenetic Study on Mineralization during Tooth Development. I.Initial Mineralization in Teeth of...
Principal Investigator：SASAGAWA Ichiro, Project Period (FY)：1993 - 1995, Research Category：Grant-in-Aid for General Scientific Research (C), Research Field：Morphological basic dentistry
Brookside Dental Care | Crowns and Bridges - Brookside Dental Care | Prestonsburg KY
Crowns are restorations that replace the visible structure of a damaged tooth. A bridge is a replacement tooth anchored by crowns or existing teeth. Call!
KAKEN - Research Projects | Analysis of tooth development of osteoprotegerin- deficient mice (KAKENHI-PROJECT-15592180)
Principal Investigator：NAKAMURA Hiroshi, Project Period (FY)：2003 - 2004, Research Category：Grant-in-Aid for Scientific Research (C), Section：一般, Research Field：Orthodontic/Pediatric dentistry
The med ma have indeed played its role because with our baby teeth we have our permanent teeth developing just under them and whatever that med was must have disrupted the tooth formation and mineralization balance. It would be interesting to find out the exact name of the med and research some current literature on it and see if it is still used. There many teeth that have side-effects in the mouth and on teeth but physicians rarely mention those side-effects ...
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Integumentary System (Skin) | HubPages
Integumentary System Skin is the largest organ of the human body which performs many essential functions. Perspiration is give, off through the skin; the skin helps regulate body temperature. The epidermis (comeum or cuticle) and dermis...
Alterations in the Integumentary System by Lee Ellen C. Kirkhorn, R Diestelmeier et al.
Lee Ellen C. Kirkhorn, R Diestelmeier, and M Diestelmeier (2013). Alterations in the Integumentary System. Pathophysiology.5th ed. St. Louis: Elsevier ...
How does the integumentary system maintain homeostasis? | Reference.com
The integumentary system maintains homeostasis by protecting the body, regulating temperature, absorbing materials and synthesizing vitamins and minerals. To achieve this, it may interact with other...
Free Biology Flashcards about Integumentary System
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Had a permanent filling in molar tooth, painful. Suggested RCT. What is going on? - Doctors insight on HealthcareMagic
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OPERATIONS ON THE INTEGUMENTARY SYSTEM(85-86) | SuperCoder.com
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Molar (tooth) | Armageddon Medicine - Survival Medicine
This web site is devoted to empowering you, the reader, to care for your loved ones and yourself when theres no other choice. Thank you for visiting and may God bless you richly in 2016 and beyond. - Doc Cindy … Continue reading ...
Index of oral health and dental articles
Odontogenesis • Odontogenic keratocyst • Odontogenic myxoma • Odontogenic cyst • Odontoma • Ohaguro • Ohio College of Dental ...
Human tooth development
Tooth development or odontogenesis is the complex process by which teeth form from embryonic cells, grow, and erupt into the ... 1995). "Odontogenesis". The International Journal of Developmental Biology. 39, N° 1. Archived from the original on 2011-07-16 ...
"Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis". Proceedings of the National Academy of Sciences of ...
Expression of FAM20C in the Osteogenesis and Odontogenesis of Mouse. Journal of Histochemistry & Cytochemistry, 58(11), 957-967 ...
Odontogenesis is a multiplex and long process of postnatal organogenesis. A tooth needs a supplemental 3 years after eruption ...
"Expression of FAM20C in the osteogenesis and odontogenesis of mouse". The Journal of Histochemistry and Cytochemistry. 58 (11 ...
... is found here both during odontogenesis and in the mature tooth. Some authors suggest that odontoblasts play an ...
Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C (1999). "Delta-notch signaling in odontogenesis: correlation with ...
Stanley Marion Garn
In relation to bone, he studied skeletal development, bone mineral loss, odontogenesis and dysmorphogenesis. His hypothesis was ...
2017 in archosaur paleontology
"Heterochronic truncation of odontogenesis in theropod dinosaurs provides insight into the macroevolution of avian beaks". ...
This is possibly the result of exposure to tetracycline during odontogenesis, however cystic fibrosis transmembrane regulator ... Several genetic disorders affect tooth development (odontogenesis), and lead to abnormal tooth appearance and structure. Enamel ...
Odontogenesis happens by means of a complex interaction between oral epithelium and surrounding mesenchymal tissue. Abnormal ...
During odontogenesis, when the dentin forms around the dental papilla, the innermost tissue is considered pulp. There are 4 ...
It may also have roles in limb-pattern formation, craniofacial development, in particular, odontogenesis, and tumor growth ...
... are a group of jaw cysts that are formed from tissues involved in odontogenesis (tooth development). ...
Animal tooth development
Play media Tooth development or odontogenesis is the process in which teeth develop and grow into the mouth. Tooth development ...
Epigenetics in forensic science
Over 300 genes have been found that are a part of odontogenesis and quite a few affect the epigenome. For example, JMJD3 is a ...
... odontogenesis). Specifically, they emerge when the process of formation extends into the abnormal sites to form small ...
It is more common in the first and second decades of life, when odontogenesis is ongoing, than in later decades. In 50% of ...
... a developmental anomaly resulting from invagination of a portion of crown forming within the enamel organ during odontogenesis ...
Maxillary lateral incisor agenesis
... and morphology of teeth among populations have been able to provide insights for genetic basis of odontogenesis. The origins of ...
Epithelial cell rests of Malassez List of cutaneous conditions Matrix Metalloproteinase-2 Tooth development and Odontogenesis ...
It is suggested that dens invaginatus arises because during odontogenesis, there is proliferation and ingrowth of the cells of ...
Evidence of common descent
2002), "Development of the Vestigial Tooth Primordia as Part of Mouse Odontogenesis", Connective Tissue Research, 43 (2-3): 120 ...
However, there are several theories: Infection Trauma Growth pressure of the dental arches during odontogenesis Rapid ...
... odontogenesis) Chemotherapy during tooth development Marshall syndrome Rieger syndrome Focal dermal hypoplasia Silver-Russell ...
List of MeSH codes (G07)
... odontogenesis MeSH G07.574.500.325.377.750.190 - amelogenesis MeSH G07.574.500.325.377.750.325 - cementogenesis MeSH G07.574. ...
Cysts of the jaws
... and so remnants of epithelium can be left in the bone during odontogenesis (tooth development). The bones of the jaws develop ...
Institute of Experimental Medicine, Academy of Sciences of the Czech Republic
Laboratory of Odontogenesis Laboratory of the Genetics of Cancer, Laboratory of DNA Repair Laboratory of Eye Histochemistry and ...
... four of which deal with odontogenesis and three with tooth eruption, and finally the last ten deal with dental diseases, four ...
Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis | PNAS
Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Olga Golonzhka, Daniel Metzger, Jean-Marc Bornert, ... Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Olga Golonzhka, Daniel Metzger, Jean-Marc Bornert, ... Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis Message Subject (Your Name) has sent you a message ... Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Olga Golonzhka, Daniel Metzger, Jean-Marc Bornert, ...
Essay On Odontogenesis - 1673 Words | Internet Public Library
Free Anatomy Flashcards about Odontogenesis
odontogenesis of dentin-containing tooth | Semantic Scholar
Antibacterial and Odontogenesis Efficacy of Mineral Trioxide Aggregate Combined with CO2 Laser Treatment. | Sigma-Aldrich
Odontogenesis | Profiles RNS
"Odontogenesis" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Odontogenesis" by people in this website by year, and whether ... Odontogenesis includes the production of tooth enamel (AMELOGENESIS), dentin (DENTINOGENESIS), and dental cementum ( ... Below are the most recent publications written about "Odontogenesis" by people in Profiles. ...
Frontiers | Wnt/β-Catenin Regulates the Activity of Epiprofin/Sp6, SHH, FGF, and BMP to Coordinate the Stages of Odontogenesis ...
... in vitro tooth development model to investigate the effects of overactivation of the Wnt/β-catenin pathway during odontogenesis ... in vitro tooth development model to investigate the effects of overactivation of the Wnt/β-catenin pathway during odontogenesis ... During odontogenesis, Epfn expression is restricted to the dental epithelium of developing molars and incisors from the bud ... Wnt/β-Catenin Regulates the Activity of Epiprofin/Sp6, SHH, FGF, and BMP to Coordinate the Stages of Odontogenesis. Maitane ...
The effects of Biodentine/polycaprolactone three‐dimensional‐scaffold with odontogenesis properties on human dental pulp cells
EX1; Practical Images - Face Development and Odontogenesis Flashcards by Courtney Kast | Brainscape
BONE DEVELOPMENT - BONE DEVELOPMENT Ossification odontogenesis development of bone Axial skull bones of cranium vertebral...
NUMBERS - Osteogenesis 6 weeks gestation Buccopharyngeal membrane seperates 21 weeks gestation Odontogenesis 6th week gestation...
JCDR - Bioengineering, Odontogenesis, Regeneration, Stem cells
Odontogenesis | definition of odontogenesis by Medical dictionary
... odontogenesis explanation free. What is odontogenesis? Meaning of odontogenesis medical term. What does odontogenesis mean? ... Looking for online definition of odontogenesis in the Medical Dictionary? ... odontogenesis imperfec´ta dentinogenesis imperfecta.. odontogenesis. [-jen′əsis] Etymology: Gk, odous, tooth, genein, to ... odontogenesis. Also found in: Dictionary, Encyclopedia, Wikipedia. odontogenesis. [o-don″to-jen´ĕ-sis] the origin and ...
GEP, a Local Growth Factor, is Critical for Odontogenesis and Amelogenesis
The goal of this study was to study whether GEP was critical for odontogenesis and amelogenesis both in vivo and in vitro. The ... GEP, a Local Growth Factor, is Critical for Odontogenesis and Amelogenesis. Int J Biol Sci 2010; 6(7):719-729. doi:10.7150/ijbs ... GEP, a Local Growth Factor, is Critical for Odontogenesis and Amelogenesis Zhengguo Cao1,2, Baichun Jiang2,3, Yixia Xie2, Chuan ... Our real-time RT-PCR data showed that GEP increased expressions of DMP1, DSPP and ALP (markers for odontogenesis, Fig. 4B). ...
Tooth Development (Odontogenesis) - Part 2 - mybetterdentists
This is the first stage of odontogenesis; it begins between the sixth and seventh week of prenatal development during embryonic ... Tooth Development (Odontogenesis) - Part 2. Posted by mybetterdentists on April 24, 2015. February 22, 2016. ... This is the first stage of odontogenesis; it begins between the sixth and seventh week of prenatal development during embryonic ...
Epigenetics in Odontogenesis and its Influences
However, epigenetic factors have indispensable effects during odontogenesis. Previous studi ... Epigenetics in Odontogenesis and its Influences [ Vol. 13 , Issue. 2 ] Author(s):. Chuwen Li, Yujia Cui, Changchun Zhou, ... Odontogenesis, epigenetics, microRNA, DNA methylation, histone modification, apoptosis. Affiliation:. State Key Laboratory of ... Background: Odontogenesis is fundamentally controlled by the genome. However, epigenetic factors have indispensable effects ...
Sonic Hedgehog Signaling in Odontogenesis - Eiki Koyama
Sonic Hedgehog Signaling in Odontogenesis. Koyama, Eiki / Thomas Jefferson University. $222,109. NIH 2002. R01 DE. Sonic ... Sonic Hedgehog Signaling in Odontogenesis. Koyama, Eiki / University of Pennsylvania. $211,360. NIH 2000. R01 DE. Sonic ... 2003) Sonic hedgehog functions as a mitogen during bell stage of odontogenesis. Connect Tissue Res 44 Suppl 1:92-6 ... Sonic Hedgehog Signaling in Odontogenesis Koyama, Eiki Thomas Jefferson University, Philadelphia, PA, United States ...
Odaph (odontogenesis associated phosphoprotein) - Chinchilla Research Resource Database
ODAPH (odontogenesis associated phosphoprotein). HGNC. HomoloGene, NCBI. Mus musculus (house mouse):. Odaph (odontogenesis ... Odaph (odontogenesis associated phosphoprotein). Transitive Ortholog Pipeline. Transitive Ortholog Pipeline. Sus scrofa (pig): ... odontogenesis associated phosphoprotein. Description:. Predicted to be involved in positive regulation of enamel mineralization ... Odaph (odontogenesis associated phosphoprotein). Transitive Ortholog Pipeline. Transitive Ortholog Pipeline. Pan paniscus ( ...
The Kinetics of Dental Liquid in Odontogenesis - Savedelicious.com
The kinetics of dental liquid in odontogenesis in the concept of the functional acid resistance of the enamel Abstract The ... The kinetics of dental liquid in odontogenesis in the concept of the functional acid resistance of the enamel ... The functional insufficiency of the crypts drainage mechanism at different stages of odontogenesis as a result of the ... The functional insufficiency of the crypts drainage mechanism at different stages of odontogenesis as a result of the ...
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Tooth Agenesis - NORD (National Organization for Rare Disorders)
PAM peptidylglycine alpha-amidating monooxygenase [Homo sapiens (human)] - Gene - NCBI
RHOA ras homolog family member A [Homo sapiens (human)] - Gene - NCBI
Proteomic Profiling of Neuroblastoma Cells Adhesion on Hyaluronic Acid-Based Surface for Neural Tissue Engineering
Index of oral health and dental articles - Wikipedia
Reelin Glycoprotein | SpringerLink
Human tooth development - Wikipedia
Paper: Bmp-Wnt Interaction Determines Dental Epithelia Cytodifferentiation through Regulation of EMT (AADR Annual Meeting ...
A novel mutation of MSX1 in oligodontia inhibits odontogenesis of dental pulp stem cells via the ERK pathway | Stem Cells Daily
Spatiotemporal Expression Patterns of Critical Genes Involved in FGF Signaling during Morphogenesis and Odontogenesis of...
- Las radiografias panoramicas debian corresponder a la primera radiografia diagnostica de pacientes sanos, sin ningun tipo de malformacion general ni maxilofacial, que no hubiesen presentado enfermedades infecciosas que alteraran la odontogenesis y los periodos de erupcion, sin exodoncias de ningun tercer molar y sin tratamiento ortodoncico previo al examen radiografico (Tabla I). (thefreedictionary.com)
- The spatiotemporal expression pattern of FGF signaling provides the foundation for future studies aiming to fine-tune dental morphogenesis and odontogenesis by controlling the interactions between the dental epithelium and mesenchyme, thereby promoting tooth regeneration in large mammals. (researchsquare.com)
- Conclusion: Epigenetic factors influence the proliferation, differentiation or apoptosis of cells that play indispensable roles during the process of odontogenesis which have the ability to exquisitely regulate the tooth number, size and shape. (currentstemcellresearchtherapy.com)
- These data strongly suggest involvement of the BMP-4 in upregulation of apoptosis also during odontogenesis. (go.jp)
- The phenotypical characteristics of teeth and namely the caries resistance essentially depends on the particularities of odontogenesis. (savedelicious.com)
- The phenotypical characteristic of teeth and namely the caries resistance essentially depends on the particularities of odontogenesis. (savedelicious.com)
- Tooth development or odontogenesis is the complex process by which teeth form from embryonic cells, grow, and erupt into the mouth. (wikipedia.org)
- Abnormal interaction between oral epithelium and underlying mesenchematic tissue during odontogenesis could result in teeth with an anatomical variation. (scielo.cl)
- Background In mammals, odontogenesis is regulated by transient signaling centers known as enamel knots (EKs), which drive the dental epithelium shaping. (muni.cz)
- odontogenesis imperfec´ta dentinogenesis imperfecta . (thefreedictionary.com)
- Odontogenesis includes the production of tooth enamel (AMELOGENESIS), dentin (DENTINOGENESIS), and dental cementum (CEMENTOGENESIS). (umassmed.edu)
- The goal of this study was to study whether GEP was critical for odontogenesis and amelogenesis both in vivo and in vitro . (ijbs.com)
- The in vitro application of recombinant GEP up-regulated molecular markers important for odontogenesis (DMP1, DSPP, and ALP) and amelogenesis (ameloblastin, amelogenin and enamelin). (ijbs.com)
- Many studies have indicated that various factors are involved in the formation of dentin and enamel during tooth development ( 16 - 26 ), although there has been no report on the role of GEP in odontogenesis and amelogenesis. (ijbs.com)
- Results Morphological structures resembling the mammalian EK were found during reptile odontogenesis. (muni.cz)
- Successful generation of Fam20C-GFP transgenic mice will provide a unique model for studying Fam20C gene expression and the biological function of this gene during odontogenesis and osteogenesis. (bvsalud.org)
- Greep R. O. Fischer C. J. and Morse A. Alkaline phosphatase in odontogenesis and osteogenesis and its histochemical demonstration after demineralization. (thejns.org)
- Dental pulp stem cells in 3D/2D co-cultures and osteogenic dental monocultures expressed markers of osteogenesis and early odontogenesis. (tufts.edu)
- Specifically , we propose to (a) determine the mechanisms of SHH signaling during odontogenesis, (b) analyze how stratum intermedium structure and phenotype change during odontogenesis, and (c) determine whether and how stratum intermedium induces and regulates ameloblast cell differentiation. (grantome.com)
- The results of the project will provide key information on morphogenetic and cellular signals responsible for initiation and progression of odontogenesis. (grantome.com)
- We used an in vitro tooth development model to investigate the effects of overactivation of the Wnt/β-catenin pathway during odontogenesis by bromoindirubin oxime reagent (BIO), a specific inhibitor of GSK-3 activity. (frontiersin.org)
- Many have replicated odontogenesis in vitro, and three dimensional cultures have been used to better replicate in vivo cell processes. (tufts.edu)
- However, variations between dental pulp stem cell lines were also observed, as one line had fewer markers of odontogenesis. (tufts.edu)
- Here, we aim to elucidate whether signaling organizers similar to EKs appear during reptilian odontogenesis and how enamel ridges are formed. (muni.cz)
- Objective: This review overviews the epigenetic mechanisms involved in odontogenesis with the aim of establishing a fundamental vision of tooth development, which might be useful in further research in odontogenesis and therapy for dental diseases. (currentstemcellresearchtherapy.com)
- Odontogenesis in voles is a convenient model to test hypotheses on tooth development generated from investigations in the mouse. (nih.gov)
- This review aims to survey the hitherto data on BMPs during tooth development with an attempt to stress a possible functional relationship between epithelial BMPs expression and regressive processes representing integral part of normal odontogenesis. (go.jp)
- Odontogenesis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- Here, we present concrete epigenetic regulation mechanisms in odontogenesis that have been reported previously, following the order of microRNA, DNA methylation and histone modification. (currentstemcellresearchtherapy.com)
- The process of odontogenesis is discussed as it is essential to understanding the pathogenesis of odontogenic tumors. (springer.com)
- Expression of both genes was sustained throughout odontogenesis. (unboundmedicine.com)
- This graph shows the total number of publications written about "Odontogenesis" by people in this website by year, and whether "Odontogenesis" was a major or minor topic of these publications. (umassmed.edu)
- Research has revealed the complex signaling that leads to odontogenesis. (tufts.edu)
- Overall, our data revealed that these proteins, originally defined through their function as β-catenin transcriptional cofactors, function in odontogenesis through a previously uncharacterized cytoplasmic mechanism, revealing that they have roles beyond that of transcriptional cofactors. (sciencemag.org)
- Below are the most recent publications written about "Odontogenesis" by people in Profiles. (umassmed.edu)
- Polymorphism in a gene, that encodes a protein involved in odontogenesis, may cause its malfunction, which may adversely affect the tooth development and eventually stop it completely. (muni.cz)