Isomeric forms and derivatives of octanol (C8H17OH).

Orexin A but not orexin B rapidly enters brain from blood by simple diffusion. (1/209)

We determined the ability of orexin A and orexin B, recently discovered endogenous appetite enhancers, to cross the blood-brain barrier (BBB) of mice. Multiple time-regression analysis showed that an i.v. bolus of 125I-orexin A rapidly entered the brain from the blood, with an influx rate (Ki = 2.5 +/- 0.3 x 10(-4) ml/g.min) many times faster than that of the 99mTc-albumin control. This relatively rapid rate of entry was not reduced by administration of excess orexin A (or leptin) or by fasting for 22 h, even when penetration into only the hypothalamus was measured. Lack of saturability also was shown by perfusion in blood-free buffer. HPLC revealed that most of the injected 125I-orexin A reached the brain as intact peptide. Capillary depletion studies showed that the administered peptide did not remain bound to the endothelial cells comprising the BBB but reached the brain parenchyma. Efflux of 125I-orexin A from the brain occurred at the same rate as 99mTc-albumin. The octanol/buffer partition coefficient of 0.232 showed that orexin A was highly lipophilic, whereas the value for orexin B was only 0.030. Orexin B, moreover, was rapidly degraded in blood, so no 125I-orexin B could be detected in intact form in brain when injected peripherally. Thus, although orexin B is rapidly metabolized in blood and has low lipophilicity, orexin A rapidly crosses the BBB from blood to reach brain tissue by the process of simple diffusion.  (+info)

Dynamics of correlated genetic systems. IV. Multilocus effects of ethanol stress environments. (2/209)

Four replicate populations of Drosophila melanogaster, two reared on medium supplemented with ethanol and two reared on standard medium, were electrophoretically monitored for 28 generations. During the first 12 generations, allelic, genotypic and gametic frequencies were determined for eight polymorphic enzymes: GOT, alpha-GPDH, MDH, ADH, TO, E6, Ec and ODH. Samples from generation 18 and 28 were electrophoretically typed for ADH and alpha-GPDH. In addition, samples from generation 27 were analyzed for the presence of inversion heterozygotes. The experimental results showed rapid gene-frequency divergence between control and treatment populations at the Adh locus in a direction consistent with the activity hierarchy of Adh genotypes. Gene-frequency divergence between control and treatment populations also occurred at the alpha-Gpdh locus, although the agreement among replicates appeared to have broken down by generation 28. No differential gene-frequency change occurred at any of the six remaining marker loci. Furthermore, values of linkage disequilibria among all linked pairs of genes were initially small and remained small throughout the course of the experiment. Taking these facts into account, it is argued that the gene-frequency response observed at ADH is most probably caused by selection at the Adh locus. The gene frequency response at alpha-Gpdh can also be be accounted for in terms of the effect of ethanol on energy metabolism, although other explanations cannot be excluded.  (+info)

Entry of CART into brain is rapid but not inhibited by excess CART or leptin. (3/209)

Cocaine- and amphetamine-regulated transcript (CART) is a new anorectic peptide found in the brain and periphery. It is closely associated with leptin, an anorectic agent saturably transported across the blood-brain barrier (BBB). Using multiple time-regression analysis, we found that CART has a rapid rate of entry into brain from blood. However, there was no self-inhibition with CART, even when perfused in blood-free buffer or in fasted mice, showing a lack of saturation. HPLC showed that at least 58% of the injected CART reached brain tissue in intact form, and capillary depletion with and without washout showed that the CART was not bound to endothelial cells or adherent to vascular components. There was no evidence for an efflux system out of the brain for CART. Thus CART can cross the BBB from blood to brain, but its rapid rate of entry is not inhibited by excess CART or leptin.  (+info)

Lipid-dependent activation of protein kinase C-alpha by normal alcohols. (4/209)

Significant stimulation of protein kinase C-alpha (PKCalpha) by n-alcohols was observed in characterized lipid systems composed of phosphatidylcholine/phosphatidylserine/dioleoylglycerol (PC/PS/DO). The logarithm of the alcohol concentrations to achieve half-maximal PKC stimulation (ED(50)) and of the maximal PKC stimulation by alcohols were both linear functions of alcohol chain length, consistent with the Meyer-Overton effect. Binding of phorbol esters to PKC was not significantly affected by octanol. Octanol increased, up to 4-fold, the affinity of PKC binding to the lipid bilayers in both the absence and presence of DO. However, octanol increased PKC activity much more significantly than it enhanced binding of the enzyme to the lipid bilayers, suggesting that the stimulation of PKC is not merely a reflection of the increase in PKC bilayer binding affinity. (31)P NMR experiments did not reveal formation of non-lamellar phases with octanol. Differential scanning calorimetry suggested that alcohols, like diacylglycerol, induce formation of compositionally distinct domains and the maximal enzyme activity with alcohol resided roughly in the putative domain-coexistence region. These results suggest that alcohols are mimicking diacylglycerol in activating PKC, not by binding to the high affinity phorbol ester binding site, but by altering lipid structure and by enhancing PKC-bilayer binding.  (+info)

Precision of the pacemaker nucleus in a weakly electric fish: network versus cellular influences. (5/209)

We investigated the relative influence of cellular and network properties on the extreme spike timing precision observed in the medullary pacemaker nucleus (Pn) of the weakly electric fish Apteronotus leptorhynchus. Of all known biological rhythms, the electric organ discharge of this and related species is the most temporally precise, with a coefficient of variation (CV = standard deviation/mean period) of 2 x 10(-4) and standard deviation (SD) of 0.12-1.0 micros. The timing of the electric organ discharge is commanded by neurons of the Pn, individual cells of which we show in an in vitro preparation to have only a slightly lesser degree of precision. Among the 100-150 Pn neurons, dye injection into a pacemaker cell resulted in dye coupling in one to five other pacemaker cells and one to three relay cells, consistent with previous results. Relay cell fills, however, showed profuse dendrites and contacts never seen before: relay cell dendrites dye-coupled to one to seven pacemaker and one to seven relay cells. Moderate (0.1-10 nA) intracellular current injection had no effect on a neuron's spiking period, and only slightly modulated its spike amplitude, but could reset the spike phase. In contrast, massive hyperpolarizing current injections (15-25 nA) could force the cell to skip spikes. The relative timing of subthreshold and full spikes suggested that at least some pacemaker cells are likely to be intrinsic oscillators. The relative amplitudes of the subthreshold and full spikes gave a lower bound to the gap junctional coupling coefficient of 0.01-0.08. Three drugs, called gap junction blockers for their mode of action in other preparations, caused immediate and substantial reduction in frequency, altered the phase lag between pairs of neurons, and later caused the spike amplitude to drop, without altering the spike timing precision. Thus we conclude that the high precision of the normal Pn rhythm does not require maximal gap junction conductances between neurons that have ordinary cellular precision. Rather, the spiking precision can be explained as an intrinsic cellular property while the gap junctions act to frequency- and phase-lock the network oscillations.  (+info)

Multiple agents potentiate alpha1-adrenoceptor-induced conduction depression in canine cardiac purkinje fibers. (6/209)

BACKGROUND: Halothane more so than isoflurane potentiates an alpha1-adrenoceptor (alpha1-AR)-mediated action of epinephrine that abnormally slows conduction in Purkinje fibers and may facilitate reentrant arrhythmias. This adverse drug interaction was further evaluated by examining conduction responses to epinephrine in combination with thiopental and propofol, which "sensitize" or reduce the dose of epinephrine required to induce arrhythmias in the heart, and with etomidate, which does not, and responses to epinephrine with verapamil, lidocaine, and l-palmitoyl carnitine, a potential ischemic metabolite. METHODS: Action potentials and conduction times were measured in vitro using two microelectrodes in groups of canine Purkinje fibers stimulated at 150 pulses/min. Conduction was evaluated each minute after exposure to 5 microm epinephrine (or phenylephrine) alone or with the test drugs. Changes in the rate of phase 0 depolarization (Vmax) and the electrotonic spread of intracellular current were measured during exposure to epinephrine with octanol to evaluate the role of inhibition of active and passive (intercellular coupling) membrane properties in the transient depression of conduction velocity. RESULTS: Lidocaine (20 microm) and octanol (0.2 mm) potentiated alpha1-AR-induced conduction depression like halothane (0.4 mm), with maximum depression at 3-5 min of agonist exposure, no decrease of Vmax, and little accentuation at a rapid (250 vs. 150 pulses/min) stimulation rate. Thiopental (95 microm), propofol (50 microm), and verapamil (2 microm) similarly potentiated epinephrine responses, whereas etomidate (10 microm) did not. Between groups, the decrease of velocity induced by epinephrine in the presence of (10 microm) l-palmitoyl carnitine (-18%) was significantly greater than that resulting from epinephrine alone (-6%; 0.05 +info)

Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic. (7/209)

Most general anesthetics including long chain aliphatic alcohols act as noncompetitive antagonists of the nicotinic acetylcholine receptor (nAChR). To locate the sites of interaction of a long chain alcohol with the Torpedo nAChR, we have used the photoactivatible alcohol 3-[(3)H]azioctanol, which inhibits the nAChR and photoincorporates into nAChR subunits. At 1 and 275 microm, 3-[(3)H]azioctanol photoincorporated into nAChR subunits with increased incorporation in the alpha-subunit in the desensitized state. The incorporation into the alpha-subunit was mapped to two large proteolytic fragments. One fragment of approximately 20 kDa (alpha V8-20), containing the M1, M2, and M3 transmembrane segments, showed enhanced incorporation in the presence of agonist whereas the other of approximately 10 kDa (alpha V8-10), containing the M4 transmembrane segment, did not show agonist-induced incorporation of label. Within alpha V8-20, the primary site of incorporation was alpha Glu-262 at the C-terminal end of alpha M2, labeled preferentially in the desensitized state. The incorporation at alpha Glu-262 approached saturation between 1 microm, with approximately 6% labeled, and 275 microm, with approximately 30% labeled. Low level incorporation was seen in residues at the agonist binding site and the protein-lipid interface at approximately 1% of the levels in alpha Glu-262. Therefore, the primary binding site of 3-azioctanol is within the ion channel with additional lower affinity interactions within the agonist binding site and at the protein-lipid interface.  (+info)

Mahogany (1377-1428) enters brain by a saturable transport system. (8/209)

The mouse mahogany gene encodes a protein that is involved in the suppression of diet-induced obesity. We studied the ability of its widely conserved C-terminal fragment to cross the blood-brain barrier (BBB) in mice. Multiple-time regression analysis showed that the entry rate (K(i)) of (125)I-mahogany (1377-1428) from blood-to-brain was 5.5 x 10(-4) ml/g. min. After coinjection of unlabeled mahogany (1377-1428), the K(i) was significantly decreased, showing the self-inhibition characteristic of a saturable transport mechanism. The excess mahogany (1377-1428) did not change the influx rate of (99m)Tcalbumin, the vascular control, indicating a lack of disruption of the BBB. Statistically significant cross-inhibition was not seen with agouti-related protein (83-132), melanin-concentrating hormone, epidermal growth factor, leptin, a melanocortin-4 receptor antagonist, or alpha-melanocyte-stimulating hormone. HPLC showed that most of the injected (125)I-mahogany (1377-1428) reached the brain intact, and capillary depletion with washout showed that most of it reached the parenchyma. There was no brain-to-blood efflux system for mahogany (1377-1428) but rather retention after i.c.v. administration, and the octanol/buffer partition coefficient showed low lipophilicity. Thus, the results show that the C-terminal peptide product encoded by the mahogany gene crosses the BBB by a transport mechanism that is saturable. The ability of this system to be regulated indicates the therapeutic potential of mahogany (1377-1428) in the treatment of obesity.  (+info)

Octanols are a type of chemical compound known as alcohols, specifically they are fatty alcohols with a chain of 8 carbon atoms. The most common octanol is called 1-octanol, which has the chemical formula CH3(CH2)7OH. It is a colorless oily liquid that is used in the synthesis of other chemicals and as a solvent. Octanols are often used as standards for measuring the partition coefficient between octanol and water, which is a measure of a compound's hydrophobicity or lipophilicity. This property is important in understanding how a compound may be absorbed, distributed, metabolized, and excreted in the body.

Other commercially important octanols are 2-octanol and 2-ethylhexanol. There are 89 possible isomers of octanol.[citation ... Octanols are alcohols with the formula C8H17OH. A simple and important member is 1-octanol, with an unbranched chain of carbons ... "Octanol". Human Metabolome Database. Retrieved 29 December 2019. (Articles with short description, Short description matches ... needed] Some octanols occur naturally in the form of esters in some essential oils. " ...
In enzymology, an octanol dehydrogenase (EC 1.1.1.73) is an enzyme that catalyzes the chemical reaction 1-octanol + NAD+ ⇌ {\ ... The systematic name of this enzyme class is octanol:NAD+ oxidoreductase. This enzyme is also called 1-octanol dehydrogenase. ... displaystyle \rightleftharpoons } 1-octanal + NADH + H+ Thus, the two substrates of this enzyme are 1-octanol and NAD+, whereas ...
... is classified fatty alcohol. A secondary alcohol, it is chiral. 2-Octanol is produced commercially by base-cleavage ... 2-Octanol (octan-2-ol, 2-OH) is an organic compound with the chemical formula CH3CH(OH)(CH2)5CH3. It is a colorless oily liquid ... Record of 2-octanol in the GESTIS Substance Database of the Institute for Occupational Safety and Health, accessed on 2 ... 2-Octanol is mainly used as: Flavor low-volatility solvent : Diverses Resins (Paints & Coatings, Adhesives, Inks, etc.), ...
... + 2-Methoxyethanol),(1-Octanol + N,N-Dimethylacetamide), and (1-Octanol + Acetophenone) at Temperatures of (298.15, ... Octanol and water are immiscible. The distribution of a compound between water and octanol is used to calculate the partition ... Many other isomers are also known generically as octanols. 1-Octanol is manufactured for the synthesis of esters for use in ... 1-Octanol hydrogen bonds to Lewis bases. It is a Lewis acid in the ECW model and its acid parameters are EA = 0.85 and C A = ...
The n-octanol-water partition coefficient, Kow is a partition coefficient for the two-phase system consisting of n-octanol and ... The value is greater than one if a substance is more soluble in fat-like solvents such as n-octanol, and less than one if it is ... Corwin Hansch later proposed the use of n-octanol as an inexpensive synthetic alcohol that could be obtained in a pure form as ... A variant of the UNIFAC system can also be used to estimate octanol-water partition coefficients. Definition of the Kow or P- ...
... (systematically named 3-methyloctan-3-ol) is an organic compound with the chemical formula CH3(CH2)4C(CH3)( ... 3-Methyl-3-octanol is a chiral compound, with each isomer yielding a different flavour. Methyl n-amyl ketone, PubChem Database ... NCBI/NIH) 3-Methyl-3-Octanol, Sigma-Aldrich Hsu, Chen-Ming; Peterson, Robert J.; Jin, Qi Zhang; Ho, Chi-Tang; Chang, Stephen S ...
... in a biphasic system of n-octanol (hereafter simply "octanol") and water: log ⁡ P oct/wat = log 10 ⁡ ( [ solute ] octanol un- ... For instance, for an octanol-water partition, it is log ⁡ P oct/wat I = log 10 ⁡ ( [ solute ] octanol I [ solute ] water I ... The partition coefficient between n-Octanol and water is known as the n-octanol-water partition coefficient , or Kow. It is ... octanol}}^{\text{ionized}}+{\big [}{\text{solute}}{\big ]}_{\text{octanol}}^{\text{un-ionized}}}{{\big [}{\text{solute}}{\big ...
The coproduct is 2-octanol. The mechanism of the base-induced cleavage is proposed to proceed by initial dehydrogenation of the ...
Octanol & glycerin is a byproduct. It can also be obtained from decalin via the tertiary hydroperoxide, which gives ...
Joseph Kenyon (1941). "d- and l-Octanol-2". Organic Syntheses.; Collective Volume, vol. 1, p. 418 George B. Payne (1973). " ...
As of October 31, 1937, 1,293.90 kg of octanol (1,146 liters), 4,342.5 kg of ethyl chloride, and 1,110.175 kg of pure ... Dibromo-1-2-ethane must be mixed with lead tetraethylate and monochloronaphthalene to obtain octanol, also called ethyl fluid, ... The main activity was the manufacture of octanol. Installed in July 1936 in Badalona, it was formed in part by the company ...
1-Octanol, with eight carbons, is practically insoluble in water, and its immiscibility leads it to be used as a standard for ... Sangster, J. (1997-05-28). Octanol-Water Partition Coefficients: Fundamentals and Physical Chemistry. John Wiley & Sons. ISBN ...
Most Cyphomyrmex species are found to contain 3-octanol. This is thought to act as an alarm signal across species. Traces of ...
... tricaine methanesulfonate and 1-octanol. Environmental Toxicology and Chemistry 6: 295-312. Laetz CA, Baldwin DH, Collier TK, ...
... tricaine methanesulfonate and 1-octanol". Environmental Toxicology and Chemistry. 6 (4): 295-312. doi:10.1002/etc.5620060407. ...
... in China the main components are geraniol and 1-octanol; and in India the main component is phenethyl alcohol. Cinnamyl alcohol ...
The octanol-water partition coefficient (Kow) of heptachlor is ~105.27. Henry's Law constant is 2.3 · 10−3atm-m3/mol and the ...
Structurally, it is a glycoside derived from glucose and octanol. Like Genapol X-100 and Triton X-100, it is a nonphysiological ...
The experimental octanol/water partition coefficient (logP) of EBB is 6.3. EBB, along with a variety of other estradiol esters ...
... is the ester of 1-octanol and gallic acid. As a food additive, it is used under the E number E311 as an ...
The experimental octanol/water partition coefficient (logP) of estradiol enanthate is 6.7. Estradiol enantate was first ...
The log octanol-water partition coefficient (log P) is -1.20E+00; its water solubility is 7.46E+05 mg/L at 25 °C. Vapor ...
The experimental octanol/water partition coefficient (logP) of estradiol dipropionate is 4.9. Estradiol dipropionate was first ...
The solubility of 1-octanol in water is 2.3 grams per liter. It was first prepared in 1908 by Bouveault-Blanc reduction of a ... Like other 8-carbon alcohols, such as 1-octanol, this compound is only slightly soluble in water but highly soluble in many ...
The experimental octanol/water partition coefficient (logP) of estradiol benzoate is 4.7. Estradiol benzoate was one of the ...
The experimental octanol/water partition coefficient (logP) of estradiol acetate is 4.2. Estradiol acetate is relatively recent ...
For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2-5 g/kg (rats, oral). Ethanol is less acutely toxic. ... An idealized synthesis of 1-octanol is shown: Al ( C 2 H 5 ) 3 + 9 C 2 H 4 ⟶ Al ( C 8 H 17 ) 3 {\displaystyle {\ce {Al(C2H5)3 ...
The octanol-water partition coefficient (Kow) of chloropicrin is estimated to be 269. Its soil adsorption coefficient (Koc; ...
Cheng T (Nov 2007). "Computation of octanol-water partition coefficients by guiding an additive model with knowledge". Journal ...
1/H Octanol: Zoct = Kow/H Pure phase of target chemical: Zpure = 1/Psv Where: R is the Ideal gas constant (8.314 Pa·m3/mol·K); ... octanol and water) is the same as the ratio between the concentrations of the target chemical in each media at equilibrium. ... T is the absolute temperature (K); H is the Henry's law constant for the target chemical (Pa/m3mol); Kow is the octanol-water ...
Other commercially important octanols are 2-octanol and 2-ethylhexanol. There are 89 possible isomers of octanol.[citation ... Octanols are alcohols with the formula C8H17OH. A simple and important member is 1-octanol, with an unbranched chain of carbons ... "Octanol". Human Metabolome Database. Retrieved 29 December 2019. (Articles with short description, Short description matches ... needed] Some octanols occur naturally in the form of esters in some essential oils. " ...
Properties Estimation: logP, logKow: Pirika method, Octanol-Water Partition Coefficient Estimation, JAVA program. Pirika method ...
BioAssay record AID 1084257 submitted by ChEMBL: Partition coefficient, log P of compound at 1:1 1-octanol/water volume ratio by spectrophotometer.
Calculating the Partition Coefficients of Organic Solvents in Octanol/Water and Octanol/Air. Authors: Nedyalkova MA, Madurga S ... The octanol/water and octanol/air partition coefficients are predicted for a group of polar solvents using density functional ... To the best of our knowledge, this is the first computational approach for the prediction of octanol/air partition coefficients ... The highest correlation to experimental data for the octanol/water partition coefficients was reached by the M11 functional; ...
1-octanol. We found that 1-octanol inhibited native T-currents at subanesthetic concentrations with an IC50 of approximately 4 ... indicating that 1-octanol stabilized inactive states of the channel. To explore the mechanisms underlying higher 1-octanol ... In contrast, 1-octanol was up to 30-fold less potent in inhibiting recombinant CaV3.3 T-channels heterologously expressed in ... The effects of 1-octanol were also abolished by chelation of intracellular calcium ions with 1,2-bis(2-aminophenoxy)ethane-N,N, ...
Sodium n-Octanol sulfate CAS 142-31-4, 30%. Sodium n - Octanol Sulfate is easily dispersible in water. It has good ... Sodium n - Octanol Sulfate is easily dispersible in water. It has good compatibility with water thats hard and high stability ...
The IUPHAR/BPS Guide to Pharmacology. octanol ligand page.
... and is much more valuable in industry than normal octanol. Octanol itself is also used as a spice, blending roses, lilies and ... In the field of plasticizers, octanol generally refers to 2- ethyl alcohol, which is a million ton grade of bulk raw material, ...
8-Dimethylamino-1-octanol. /shop/product/8-dimethylamino-1-octanol-260188 ¥ 1.00 ¥ 1.00 1.0 CNY ¥ 1.00 Product not available. ...
Basic properties Density, g/ml (20ºС) 0.819 Refractive index, n20D 1.426 Boiling point, ºС 54.0 - 56.0 (9 mmHg)
2-Octanol ethoxylates. Feel free to send an inquiry to get the latest price of Sec-Octyl alcohol ethoxylates;2-Octanol ... If you would like to buy Sec-Octyl alcohol ethoxylates;2-Octanol ethoxylates in bulk.Product Performance of Sec-Octyl alcohol ... ethoxylates;2-Octanol ethoxylates:Good dispersion in water, 1% aqueous solution is a milky white liquid, no gel phase during ... 2-Octanol ethoxylates:Good dispersion in water, 1% aqueous solution is a milky white liquid, no gel phase during dissolution. ...
One stop solution for all your energy curing (UV/EB) requirements, customized specialties and basic chemicals.
Perfume formula usage statistics for 3-octanol, gathered from thousands of publicly available perfume formulas ... Still, We can tell you that the minimum dosage of 3-octanol we encountered is 0.010%, the mean dose is 0.017%, and the maximum ... Our database does not have enough perfume formulas containing 3-octanol to produce meaningful statistics. ...
TerraQSAR-LOGP computed octanol/water partition coefficients (CLOGPs). For other toxicity and effect values, such as mammalian ...
Investigative Science, The Octanol/Water Coefficient: What is it & How Good is it? Watsons Notes Vol. 12, No. 1 (November ... The Octanol/water coefficient: What is it for & How Good is it. ...
Prices of Isomeric Octanol Ethoxylates You can buy if you want to Isomeric Octanol Ethoxylates Bulk d ... Isomeric octanol ethoxylates Properties. This agent is good for cleaning and penetrating. It has high permeability and washing ... Active matter value: >=99.5 Isomeric octanol-ethoxylates - What they are: Rich foam with high permeability is a great penetrant ... It is a global trusted brand Isomeric Octanol Etoxylate . Send an inquiry for the latest. ...
Isomeric octanol ethoxylates Properties. HOT PRODUCTS June 14,2023 SAEO Diethylene glycol monoethylether. ...
As an Enterprise Family, New Sunlion Chemical Group is consisted of Wujiang New Sunlion Chemical Co., Ltd., Wujiang Hailian Chemical Import & Export Co., Ltd., Lianyungang Sunlion Chemical Co., Ltd. and Weifang Runan Chemical Technology Co., Ltd.Committing to the development, production and service of fine chemicals...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
As an Enterprise Family, New Sunlion Chemical Group is consisted of Wujiang New Sunlion Chemical Co., Ltd., Wujiang Hailian Chemical Import & Export Co., Ltd., Lianyungang Sunlion Chemical Co., Ltd. and Weifang Runan Chemical Technology Co., Ltd.Committing to the development, production and service of fine chemicals...
Octane, octanol, octanal.... Lower peaks on the GC graphs made us very proud. The biobricks reduce alkanes up to C30 to thin ...
1-Octanol (capryl). *1-Nonanol (pelargonic). Straight-chain. saturated. C10 - C19. *1-Decanol (capric) ...
Before OECD Guideline 405 was established, eye irritation was tested using an internal method. White Vienna rabbits were used. 50 µl of the test substance was applied to the conjunctival sac of one eye in 2 animals. The saline-treated adjacent eye served as control. The animals were observed several times on the day of treatment and up to 8 days afterwards. The eyes were not washed out after 24 hours ...
To extend the Koctrange which can be determine by CPC, the system hexane (60%) octanol (40%)-water was used. A single linear ... The mobile phase must be water and the stationary phase must be octanol for accurate determination of the larger Koctvalues. To ... Octanol-water partition coefficients (Koct) are one of the accepted physico-chemical parameters for predicting the biological ... Octanol-water partition coefficients (Koct) are one of the accepted physico-chemical parameters for predicting the biological ...
... n-octanol and 2 in kerosene alone. When 1 is diluted in the alcohol-based diluents ExxalTM 10 and n-octanol, very clear phase ... n-octanol shows very high Pd(II) extraction ability (E% = 99.81%) by 1. The diluent n-octanol acts as a phase modifier and ... Furthermore, stripping of Pd(II) from the kerosene/n-octanol phase after leaching was performed using 1 M HCl, 1 M HNO3, 10% (v ... Conditions: Metal ions = 100 mg/L each; [HCl] = 0.5 M; [1] = 1 mM; diluent = kerosene + 20% n-octanol; time = 30 min; O/A = 1; ...
octanol indole dimethyl sulfone. burnt. camphene hydrate. camphor. palmitaldehyde 5-oxymethylfurfurole. cardboard. ...
  • The octanol/water and octanol/air partition coefficients are predicted for a group of polar solvents using density functional theory (DFT) calculations in combination with a solvation model based on density (SMD) and are in excellent agreement with experimental data. (simulations-plus.com)
  • To the best of our knowledge, this is the first computational approach for the prediction of octanol/air partition coefficients by DFT calculations, which has remarkable accuracy and precision. (simulations-plus.com)
  • Octanol-water partition coefficients (Koct) are one of the accepted physico-chemical parameters for predicting the biological effects of organic chemicals. (mst.edu)
  • For impervious surfaces, dimensionless partitioning coefficients were calculated and found to be comparable to reported values of the octanol-air partition coefficients of phthalates, K oa , suggesting that an organic film may develop on these surfaces. (acs.org)
  • The temperature dependencies of partition coefficients of new hybrids in the model system 1-octanol/buffer pH 7.4 as a surrogate lipophilicity were measured by the shake flask method. (bvsalud.org)
  • Temperature dependences of the compound partition coefficients were obtained in a binary 1-octanol/buffer pH 7.4 system and the transfer thermodynamic functions were calculated. (bvsalud.org)
  • for the octanol/air partition coefficient, the M06-2X functional yielded the best performance. (simulations-plus.com)
  • V. Octanol-water Partition Coeff" by Alain Berthod, Yoon Il Han et al. (mst.edu)
  • The important physicochemical properties of three novel bioactive hybrid compounds with different groups (-CH3, -F and -Cl) were studied, including kinetic and thermodynamic solubility in pharmaceutically relevant solvents (buffer solutions and 1-octanol) as well as partition coefficient in system 1-octanol/buffer pH 7.4. (bvsalud.org)
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  • Octanol Polyoxyethylene Ether: Octanol polyoxyethylene is a type of non-ionic detergent, soluble in aqueous solutions without gel phase. (cookingmamacookoff.com)
  • In contrast, 12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5 H -indolo(2,3- a )pyrrolo(3,4- c )-carbazole (Go 6976), an inhibitor of calcium-dependent PKC, decreased baseline T-current amplitude in nRT cells and abolished the effects of subsequently applied 1-octanol. (aspetjournals.org)
  • In this research, tartaric acid was separated from the aqueous phase using chemical and organic solvents such as groundnut oil, mustard oil, kerosene, octanol, and methyl isobutyl ketone (MIBK). (uni-pannon.hu)
  • A fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7. (chemspider.com)
  • Octanols are alcohols with the formula C8H17OH. (wikipedia.org)
  • The objects of investigation are monohydric alcohols n-pentanol (CH2)4CH3-OH and n-octanol (CH2)7CH3-OH. (kiev.ua)
  • To extend the Koctrange which can be determine by CPC, the system hexane (60%) octanol (40%)-water was used. (mst.edu)
  • The isothermal saturation method was used to determine the drug solubility in seven pharmaceutically relevant solvents within the temperature range from 293.15 to 313.15 K. The IVZ solubility in the studied solvents increased in the following order: buffer pH 7.4, buffer pH 2.0, buffer pH 1.2, hexane, 1-octanol, 1-propanol, ethanol. (bvsalud.org)
  • The results demonstrate the significance of solvent choice in the extraction of tartaric acid with solvents such as MIBK and octanol being more effective at extracting TA from aqueous solutions. (uni-pannon.hu)
  • Here, we recorded T-currents and underlying low-threshold calcium spikes from neurons of nucleus reticularis thalami (nRT) in brain slices from young rats and investigated the mechanisms of their modulation by an anesthetic alcohol, 1-octanol. (aspetjournals.org)
  • In the field of plasticizers, octanol generally refers to 2- ethyl alcohol, which is a million ton grade of bulk raw material, and is much more valuable in industry than normal octanol. (romalimited.com)
  • citation needed] Some octanols occur naturally in the form of esters in some essential oils. (wikipedia.org)
  • In the present study, we found that a 1-octanol/buffer biphasic system improved the yield of theaflavin 3-gallate in a tyrosinase-catalyzed synthetic reaction with (-)-epicatechin and (-)-epigallocatechin gallate. (elsevierpure.com)
  • We found that 1-octanol inhibited native T-currents at subanesthetic concentrations with an IC 50 of approximately 4 μM. (aspetjournals.org)
  • To explore the mechanisms underlying higher 1-octanol potency in inhibiting native nRT T-currents, we tested the effect of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) and PKC inhibitors. (aspetjournals.org)
  • The mobile phase must be water and the stationary phase must be octanol for accurate determination of the larger Koctvalues. (mst.edu)
  • However, self-dimerization was suppressed in the octanol phase, allowing oxidized (-)-epigallocatechin gallate to participate in coupling with (-)-epicatechin quinone, leading to effective production of theaflavin 3-gallate. (elsevierpure.com)
  • Furthermore, the preferential localization of theaflavin 3-gallate in the octanol phase prevented (-)-epicatechin-quinone-induced degradation. (elsevierpure.com)
  • Our database does not have enough perfume formulas containing 3-octanol to produce meaningful statistics. (unguentarius.com)
  • In this work, quantum chemical methods are used to predict water-octanol partition coefficients as a part of the SAMPL6 blind challenge. (nih.gov)
  • Data for the partition coefficients (n-octanol-water) (Pow) of 221 pesticides and pesticide metabolites are presented with their method of derivation and source. (qld.gov.au)
  • Octanol-water partition coefficients are measured by shake-flask methods, reversed-phase HPLC, reversed-phase TLC, slow-stirring partition methods and column generator method. (qld.gov.au)
  • Octanol-water partition coefficients are calculated from substituent constants, molecular fragment summation and solubilities. (qld.gov.au)
  • Predicting Octanol/Water Partition Coefficients of Alcohol Ethoxylate Su. (rwth-aachen.de)
  • 1-Octyl β-D-xylobioside and xyloside were prepared by direct transglycosylation reaction of xylan and 1-octanol using purified xylanase from Aureobasidium pullulans. (elsevierpure.com)
  • The proposed mechanism for production of octyl xylobioside and xyloside involved the reaction of xylan and octanol by xylanase to produce octyl xylobioside and xylotrioside, the latter of which was simultaneously hydrolyzed by xylanase into octyl xyloside and xylobiose. (elsevierpure.com)
  • Matsumura, S, Sakiyama, K & Toshima, K 1999, ' Preparation of octyl β-D-xylobioside and xyloside by xylanase-catalyzed direct transglycosylation reaction of xylan and octanol ', Biotechnology Letters , vol. 21, no. 1, pp. 17-22. (elsevierpure.com)
  • The team found that the bacteria produced odor compounds related to octanol. (nih.gov)
  • Worms normally avoid high concentrations of octanol. (nih.gov)
  • Hydrophobic molecular similarity from MST fractional contributions to the octanol/water partition coefficient. (irbbarcelona.org)
  • This study evaluated the efficacy of a predictive model utilized by the National Institute for Occupational Safety and Health to identify dermal hazards based on potential of systemic absorption compared to hazard assignments based on dermal lethal dose 50% or logarithm of octanol-water partition coefficient. (cdc.gov)
  • Absorption Dynamics of Organic Chemical Transport across Trout Gills as Related to Octanol-Water Partition Coefficient. (epa.gov)
  • The Partition Coeffiecient n-octanol/water of Cyclamen Aldehyde was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117. (europa.eu)
  • Image analysis of spread of the fluorescence profile of microinjected fura 2 salt revealed an effective diffusion coefficient for fura 2 of 21.0±3.3 μm 2 /s, which decreased to 12.6±1.5 and 7.07±0.7 μm 2 /s after 1 and 3 hours of exposure, respectively, to 100 μmol/L octanol, with a time constant of decline of 1.5±0.5 hours. (elsevierpure.com)
  • The SMD continuum solvent model was employed with MP2 and eight DFT functionals in conjunction with correlation consistent basis sets to determine the water-octanol transfer free energy. (nih.gov)
  • The hydrophobic similarity index exploits atomic contributions to the octanol/water transfer free energy, which are evaluated by means of the fractional partitioning scheme developed within the framework of the Miertus-Scrocco-Tomasi continuum model. (irbbarcelona.org)
  • Several tactics towards improving the predictions of the partition coefficient were examined, including increasing the quality of basis sets, considering tautomerization, and accounting for inhomogeneities in the water and n-octanol phases. (nih.gov)
  • We studied the role of Ca 2+ diffusion through gap junctions (GJs) in triggering trod propagation of damage induced contractions in cardiac muscle (TPCs) by evaluating effects of the GJ blockers octanol and heptanol (O and H) on TPCs. (elsevierpure.com)