Occludin: A MARVEL domain protein that plays an important role in the formation and regulation of the TIGHT JUNCTION paracellular permeability barrier.Tight Junctions: Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, p22)Zonula Occludens-1 Protein: A 195-kDa zonula occludens protein that is distinguished by the presence of a ZU5 domain at the C-terminal of the molecule.Virus Internalization: The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.Antigens, CD81: Tetraspanin proteins that are involved in a variety of cellular functions including BASEMENT MEMBRANE assembly, and in the formation of a molecular complexes on the surface of LYMPHOCYTES.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Claudin-1: An integral membrane protein that is localized to TIGHT JUNCTIONS, where it plays a role in controlling the paracellular permeability of polarized cells. Mutations in the gene for claudin-1 are associated with Neonatal Ichthyosis-Sclerosing Cholangitis (NISCH) Syndrome.Hepacivirus: A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.Zonula Occludens-2 Protein: A zonula occludens protein subtype found in epithelial cell junctions. Several isoforms of zonula occludens-2 protein exist due to use of alternative promoter regions and alternative mRNA splicings.Claudins: A large family of transmembrane proteins found in TIGHT JUNCTIONS. They take part in the formation of paracellular barriers and pores that regulate paracellular permeability.Claudin-5: A claudin subtype that is found localized to TIGHT JUNCTIONS in VASCULAR ENDOTHELIAL CELLS. The protein was initially identified as one of several proteins which are deleted in VELOCARDIOFACIAL SYNDROME and may play an important role in maintaining the integrity of the BLOOD-BRAIN BARRIER.Tight Junction Proteins: Proteins that take part in the formation or structure of TIGHT JUNCTIONS.Electric Impedance: The resistance to the flow of either alternating or direct electrical current.Caco-2 Cells: Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation.PhosphoproteinsMARVEL Domain Containing 2 Protein: A tight junction-associated MARVEL protein that may play a role in separating the endolymphatic and perilymphatic spaces of the ORGAN OF CORTI. Defects in the gene that codes for MARVELD2 protein are a cause of deafness autosomal recessive type 49.Permeability: Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.Blood-Testis Barrier: A specialized barrier, in the TESTIS, between the interstitial BLOOD compartment and the adluminal compartment of the SEMINIFEROUS TUBULES. The barrier is formed by layers of cells from the VASCULAR ENDOTHELIUM of the capillary BLOOD VESSELS, to the SEMINIFEROUS EPITHELIUM of the seminiferous tubules. TIGHT JUNCTIONS form between adjacent SERTOLI CELLS, as well as between the ENDOTHELIAL CELLS.Cell Membrane Permeability: A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.Blood-Retinal Barrier: A specialized transport barrier, in the EYE, formed by the retinal pigment EPITHELIUM, and the ENDOTHELIUM of the BLOOD VESSELS of the RETINA. TIGHT JUNCTIONS joining adjacent cells keep the barrier between cells continuous.Claudin-3: A ubiquitously-expressed claudin subtype that acts as a general barrier-forming protein in TIGHT JUNCTIONS. Elevated expression of claudin-3 is found in a variety of tumor cell types, suggesting its role as a therapeutic target for specific ANTINEOPLASTIC AGENTS.Freeze Fracturing: Preparation for electron microscopy of minute replicas of exposed surfaces of the cell which have been ruptured in the frozen state. The specimen is frozen, then cleaved under high vacuum at the same temperature. The exposed surface is shadowed with carbon and platinum and coated with carbon to obtain a carbon replica.Blood-Brain Barrier: Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.Junctional Adhesion Molecules: A family of membrane glycoproteins localized to TIGHT JUNCTIONS that contain two extracellular Ig-like domains, a single transmembrane segment, and a cytoplasmic tail of variable length.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Adherens Junctions: Anchoring points where the CYTOSKELETON of neighboring cells are connected to each other. They are composed of specialized areas of the plasma membrane where bundles of the ACTIN CYTOSKELETON attach to the membrane through the transmembrane linkers, CADHERINS, which in turn attach through their extracellular domains to cadherins in the neighboring cell membranes. In sheets of cells, they form into adhesion belts (zonula adherens) that go all the way around a cell.Period Circadian Proteins: Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.Cryptochromes: Flavoproteins that function as circadian rhythm signaling proteins in ANIMALS and as blue-light photoreceptors in PLANTS. They are structurally-related to DNA PHOTOLYASES and it is believed that both classes of proteins may have originated from an earlier protein that played a role in protecting primitive organisms from the cyclical exposure to UV LIGHT.GermanyFlavoproteinsPhotoreceptor Cells, Invertebrate: Specialized cells in the invertebrates that detect and transduce light. They are predominantly rhabdomeric with an array of photosensitive microvilli. Illumination depolarizes invertebrate photoreceptors by stimulating Na+ influx across the plasma membrane.Gap Junctions: Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.Desmoplakins: Desmoplakins are cytoskeletal linker proteins that anchor INTERMEDIATE FILAMENTS to the PLASMA MEMBRANE at DESMOSOMES.Desmosomes: A type of junction that attaches one cell to its neighbor. One of a number of differentiated regions which occur, for example, where the cytoplasmic membranes of adjacent epithelial cells are closely apposed. It consists of a circular region of each membrane together with associated intracellular microfilaments and an intercellular material which may include, for example, mucopolysaccharides. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990; Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Intercellular Junctions: Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Transendothelial and Transepithelial Migration: The passage of cells across the layer of ENDOTHELIAL CELLS, i.e., the ENDOTHELIUM; or across the layer of EPITHELIAL CELLS, i.e. the EPITHELIUM.Neutrophil Infiltration: The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.Cell Migration Assays, Leukocyte: Assays that measure the rate of migration of LEUKOCYTES. They may involve a variety of techniques such as measuring the movement of leukocytes through substrates such as AGAROSE gels or the rate of exit of cells from a glass capillary.Chemotaxis, Leukocyte: The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.N-Formylmethionine Leucyl-Phenylalanine: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Interferon Inducers: Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesWheat Germ Agglutinins: Lectins purified from the germinating seeds of common wheat (Triticum vulgare); these bind to certain carbohydrate moieties on cell surface glycoproteins and are used to identify certain cell populations and inhibit or promote some immunological or physiological activities. There are at least two isoforms of this lectin.Recombinant Proteins: Proteins prepared by recombinant DNA technology.
Epithelial-associated genes such as E-cadherin/Cdh1, Cldns −3, −4, −7, −11, Occludin (Ocln), Epithelial cell adhesion molecule ...
... is a protein that in humans is encoded by the OCLN gene. Occludin is a 65-kDa (522-amino acid polypeptide -human) ... "Entrez Gene: OCLN occludin". Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S (1993). "Occludin: a ... Occludin also plays an important role in the apoptosis. The C-terminus of occludin is important in receiving and transmitting ... Occludin plays a critical role in maintaining the barrier properties of a tight junction. Thus, mutation or absence of occludin ...
Mutations in the gene OCLN on chromosome 5q13.2, which is thought to cause band-like calcification in the brain, have been ... "Recessive mutations in the gene encoding the tight junction protein occludin cause band-like calcification with simplified ...
... and Occludin. Once inside the hepatocyte, HCV takes over portions of the intracellular machinery to replicate. The HCV genome ... "Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry". Journal of Virology. 84 ...
Ausgesuchte Qualitäts-Hersteller für Occludin Antikörper. Hier bestellen. ... Monoklonale und polyklonale Occludin Antikörper für viele Methoden. ... anti-Occludin (OCLN) Antikörper. Bezeichnung:. anti-Occludin Antikörper (OCLN). Auf www.antikoerper-online.de finden Sie ... occludin b , tight-junction protein , thiopurine methyltransferase , occludin , occludin-like , tight junction protein occludin ...
Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely ... Much to our surprise, however, we have now also discovered several major TJ proteins (claudins 1 and 4, occludin, cingulin, ...
Occludin is a protein that in humans is encoded by the OCLN gene. Occludin is a 65-kDa (522-amino acid polypeptide -human) ... "Entrez Gene: OCLN occludin". Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S (1993). "Occludin: a ... Occludin also plays an important role in the apoptosis. The C-terminus of occludin is important in receiving and transmitting ... Occludin plays a critical role in maintaining the barrier properties of a tight junction. Thus, mutation or absence of occludin ...
Jetzt diesen anti-Occludin Antikörper bestellen. , Produkt ABIN657822 ... Kaninchen Polyklonal Occludin Antikörper AA 446-474, C-Term für WB. Publiziert in 2 Pubmed Referenzen. ... anti-Occludin Antikörper (OCLN) (AA 446-474) Occludin Antikörper (OCLN) (AA 446-474). Details for Product anti-OCLN Antibody No ... Target Details Occludin Referenzen Bilder Handhabung Anwendungsinformationen zurück nach oben Target Details Occludin Anzeigen ...
Gene names: MUC2, mucin 2; OCLN, occludin; TLR, Toll-like-receptor; ZO1, zonula occludens-1. ... OCLN, occludin; PYY, peptide YY/peptide tyrosine tyrosine; SMCT, solute carrier family 5 (sodium-monocarboxylate transporter), ...
Buy our Recombinant Human Occludin protein. Ab114190 is a protein fragment produced in Wheat germ and has been validated in WB ... Defects in OCLN are the cause of band-like calcification with simplified gyration and polymicrogyria (BLCPMG) [MIM:251290]; ...
OCLN; occludin [KO:K06088]. 50848 F11R; F11 receptor [KO:K06089]. 58494 JAM2; junctional adhesion molecule 2 [KO:K06735]. ... TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- ...
OCLN; occludin [KO:K06088]. 50848 F11R; F11 receptor [KO:K06089]. 58494 JAM2; junctional adhesion molecule 2 [KO:K06735] ...
Rabbit polyclonal Occludin antibody - Neural Stem Cell Marker. Validated in WB, IHC and tested in Mouse, Human. Cited in 16 ... Defects in OCLN are the cause of band-like calcification with simplified gyration and polymicrogyria (BLCPMG) [MIM:251290]; ... All lanes : Anti-Occludin antibody - Neural Stem Cell Marker (ab168986) at 1 µg/ml. Lane 1 : Occludin-transfected 293T cell ... Anti-Occludin antibody - Neural Stem Cell Marker. See all Occludin primary antibodies. ...
Occludin (OCLN) and ... 478. Glucose metabolism and proliferation in glia: role of astrocytic gap junctions. ...
Ocln. occludin. 2. 30,527,327. 30,577,218. RGD:6480464. G. P2rx1. purinergic receptor P2X 1. 10. 59,566,268. 59,581,328. RGD: ...
OCLN occludin. PPP1R115. 5q13.2. OPN3 opsin 3. ECPN. PPP1R116, NMO-1, encephalopsin, ERO. 1q43. ...
Anti-Rat Occludin (1A8) Mouse IgM MoAb. Occludin is an integral membrane protein, encoded by the OCLN gene, that is located at ... When occludin is expressed in cells that lack tight junctions, it is able to induce cell adhesion. Mutations in the OCLN gene ... Occludin is also known as BLCPMG. It is known to interact with several cytoplasmic proteins via its C terminus, while its ... This product is an affinity-purified IgG antibody that recognizes rat occludin protein. The antibody was raised in mouse using ...
the tight junction protein occludin (OCLN) *the B cell receptor. of HCV-associated lymphomaref, thus activating the ... The polarized nature of hepatocytes and the tight junction roles of OCLN and CLDN1 suggest an entry pathway similar to that of ...
Gene expressions of Ocln, which encodes occludin (P , 0.01; Fig. 4A), Tjp1, which encodes tight junction protein 1 (P , 0.01; ... Relative gene expression of Ocln (A), Tjp1 (B), Cldn8 (C), Cldn15 (D), Muc1 (E), and Muc2 (F) in ileum and colon from 4-week- ... Ocln (P , 0.05) gene expression was also elevated in the colon together with a tendency for higher expression of Muc1, which ... Ocln, Tjp1, Cldn8, Cldn15, Muc1, and Muc2 TaqMan gene expression assays (Applied Biosystems) were used for quantitative PCR ( ...
Invitrogen Anti-Occludin Recombinant Monoclonal (6H10L9), Catalog # 701161. Tested in Western Blot (WB), Immunofluorescence (IF ... Protein Aliases: Occludin; OCLN; phosphatase 1, regulatory subunit 115; tight junction protein occludin ... Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin ... Cite Occludin Recombinant Rabbit Monoclonal Antibody (6H10L9). The following antibody was used in this experiment: Occludin ...
OCLN, LOC529061, LOC529061, FHIT, and LOC782601). The last group of genes plays a role in different metabolic pathways, ...
Occludin (OCLN). Rabbit IgG. IF. ABIN1714069. Runt-Related Transcription Factor 3 (RUNX3). Rabbit IgG. IF. ...
24 antibodies to Occludin and validated for use in 6 applications (Immunohistochemistry,Flow Cytometry,Western Blot, ... Occludin Antibodies Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to ... The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at ... Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty ...
Ocln gRNA vector 1 in pCas-Guide vector- KN311431G2, Ocln gRNA vector 2 in pCas-Guide vector- KN311431D, donor vector… ... Background of Occludin antibody. Kit Component:. - KN311431G1, Ocln gRNA vector 1 in pCas-Guide vector. - KN311431G2, Ocln gRNA ... Recombinant protein of human occludin (OCLN). Human. > 80 % Preparation: Recombint protein was captured through anti-DDK ... OCLN monoclonal antibody (M01), clone 1G7 Western Blot analysis of OCLN expression in HL-60 ( Cat # L014V1 ).. *H00004950-M01 ...
Ocln gRNA vector 1 in pCas-Guide vector- KN311431G2, Ocln gRNA vector 2 in pCas-Guide vector- KN311431D, donor vector… ... Background of Occludin antibody. Kit Component:. - KN311431G1, Ocln gRNA vector 1 in pCas-Guide vector. - KN311431G2, Ocln gRNA ... OCLN monoclonal antibody (M01), clone 1G7 Western Blot analysis of OCLN expression in HL-60 ( Cat # L014V1 ).. *H00004950-M01 ... OCLN polyclonal antibody (A01), Lot # 051207JC01 Western Blot analysis of OCLN expression in Jurkat ( Cat # L017V1 ).. * ...
anti-Occludin antibody (OCLN) (AA 480-520) Rabbit, Polyclonal, IgG. Supplier: Log in to see ... Show selected OCLN Antibodies with more information such as references or interaction partners. ...
Under healthy conditions, endothelial cells express TJ proteins CLDN5 and occludin (OCLN), which reinforce a closed BBB. In ... Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium. Am J Physiol ... Therefore, under healthy conditions, the BBB is closed and enforced by CLDN5 and occludin. The encircling GL is open and does ... and occludin (7). Beyond the BBB lies the perivascular space (PVS), where leukocytes encounter CNS antigen in the context of ...
Occludin. Novus Biologicals. polyclonal. Mouse. (mouse antisera, glycerol, no preservative). ELISA, WB. Human. immunogen = OCLN ... reacts with occludin, ~65 kDa. -. Occludin, C-term GST. Zymed/ Invitrogen. polyclonal. Ig. Rabbit. (antiserum, PBS, azide, ... reacts specifically with occludin. -. Occludin, C-term. Zymed/ Invitrogen. polyclonal. Ig. Rabbit. (antiserum, PBS, azide, ... reacts with occludin, ~65 kDa. -. Occludin. Zymed/ Invitrogen. polyclonal. Ig. Rabbit. (antiserum, PBS, azide, affinity ...
  • Wnt4 stimulated the proliferation of follicular granulosa cells (GCs), increased the expression of StAR and CYP11A1 mRNA in prehierarchical and hierarchical follicles, increased the expression of FSHR mRNA, and decreased the expression of anti-Müllerian hormone and OCLN mRNA. (frontiersin.org)
  • The occludin mRNA level was compared between paraffin-embedded tissues of 40 patients with melanoma and 10 subjects with normal skin. (iranpath.org)
  • This data set includes descriptions of DEFINITION Homo sapiens occludin (OCLN), transcript variant 1, mRNA. (rroij.com)
  • Matrices listed below were spiked with certain level of recombinant Rabbit OCLN and the recovery rates were calculated by comparing the measured value to the expected amount of Rabbit OCLN in samples. (abebio.com)
  • Consistent with these findings, our recent studies shown that the knockdown of LDLr, CD81, claudin-1, occludin, and SR-B1 appearance in Huh-7.5 cells did not significantly affect HCV attachment but incredibly reduced HCV infection, also suggesting their importance at postattachment actions in HCV infection (32). (cylch.org)
  • This protocol was developed to overcome the limited availability of mouse brain endothelial cell lines that maintain their key characteristics, e.g. , the expression of sufficient amounts of tight junction proteins such as occludin, ZO-1 or claudin-5 to induce a high transendothelial resistance. (bio-protocol.org)
  • To evaluate the effect of each compound on limited junctions and focal adhesions healthy proteins levels, western blot analysis of claudin-2 (CLDN2), OCLN and vinculin (VCL) were performed. (bus2226w16.com)
  • challenge suppressed neutral amino acid transporter 1 ( B 0 AT1) , peptide transporter 1 ( PEPT1) , toll-like receptor 5 ( TLR5) , interleukin 2 ( IL2) , and occludin ( OCLN) gene expression and enhanced cationic amino acid transporter 1 ( CAT-1) and interferon gamma ( IFNG) gene expression. (biomedcentral.com)
  • Synthetic peptide conjugated to KLH derived from within residues 350 - 450 of Human Occludin. (abcam.cn)
  • The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Rabbit OCLN and their serial dilutions. (abebio.com)
  • Some customers have successfully used ab31721 with Mouse/Rat lysates/tissue, however we have not been successful detecting Occludin in these species in our own testing. (abcam.cn)
  • Furthermore, ectopic occludin expression in IGF2BP1-knockdown cells restored barrier function. (elsevier.com)