Lymphocytes, Null: A class of lymphocytes characterized by the lack of surface markers specific for either T or B lymphocytes.Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Lymphocyte Subsets: A classification of lymphocytes based on structurally or functionally different populations of cells.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Lymphocyte Count: The number of LYMPHOCYTES per unit volume of BLOOD.Antelopes: Any of various ruminant mammals of the order Bovidae. They include numerous species in Africa and the American pronghorn.Saudi ArabiaDesert Climate: A type of climate characterized by insufficient moisture to support appreciable plant life. It is a climate of extreme aridity, usually of extreme heat, and of negligible rainfall. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Microscopy, Electron, Scanning: Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.Microscopy, Electron, Transmission: Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Rheumatoid Nodule: Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.Rheumatoid Factor: Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.Antigens, CD8: Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.Antigens, CD3: Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).Antirheumatic Agents: Drugs that are used to treat RHEUMATOID ARTHRITIS.CD40 Ligand: A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.Precursor T-Cell Lymphoblastic Leukemia-Lymphoma: A leukemia/lymphoma found predominately in children and young adults and characterized LYMPHADENOPATHY and THYMUS GLAND involvement. It most frequently presents as a lymphoma, but a leukemic progression in the bone marrow is common.Lymphoma, T-Cell, Cutaneous: A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.Sezary Syndrome: A form of cutaneous T-cell lymphoma manifested by generalized exfoliative ERYTHRODERMA; PRURITUS; peripheral lymphadenopathy, and abnormal hyperchromatic mononuclear (cerebriform) cells in the skin, LYMPH NODES, and peripheral blood (Sezary cells).Receptor, EphB2: An eph family receptor found widely expressed in embryonic and adult tissues. High levels of EphB2 receptor are observed in growing AXONS and NERVE FIBERS. Several isoforms of the protein exist due to multiple alternative mRNA splicing.Myeloid Cell Leukemia Sequence 1 Protein: A member of the myeloid leukemia factor (MLF) protein family with multiple alternatively spliced transcript variants encoding different protein isoforms. In hematopoietic cells, it is located mainly in the nucleus, and in non-hematopoietic cells, primarily in the cytoplasm with a punctate nuclear localization. MLF1 plays a role in cell cycle differentiation.Receptors, Eph Family: A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. Members of this family have been implicated in regulation of cell-cell interactions involved in nervous system patterning and development.Leukemia-Lymphoma, Adult T-Cell: Aggressive T-Cell malignancy with adult onset, caused by HUMAN T-LYMPHOTROPIC VIRUS 1. It is endemic in Japan, the Caribbean basin, Southeastern United States, Hawaii, and parts of Central and South America and sub-Saharan Africa.Thioglycolates: Organic esters of thioglycolic acid (HS-CH2COOH).Peritonitis: INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.Thiocapsa roseopersicina: A species of THIOCAPSA which is facultatively aerobic and chemotrophic and which can utilize thiosulfate. (From Bergey's Manual of Determinative Bacteriology, 9th ed)Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Selenoprotein P: An extracellular selenoprotein that contains most of the SELENIUM in PLASMA. Selenoprotein P functions as an antioxidant and appears to transport selenium from the LIVER to peripheral tissues.Mice, Inbred C57BLNeutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.DNA Ligases: Poly(deoxyribonucleotide):poly(deoxyribonucleotide)ligases. Enzymes that catalyze the joining of preformed deoxyribonucleotides in phosphodiester linkage during genetic processes during repair of a single-stranded break in duplex DNA. The class includes both EC 6.5.1.1 (ATP) and EC 6.5.1.2 (NAD).Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Genes, Lethal: Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.Nijmegen Breakage Syndrome: A chromosome instability syndrome resulting from a defective response to DNA double-strand breaks. In addition to characteristic FACIES and MICROCEPHALY, patients have a range of findings including RADIOSENSITIVITY, immunodeficiency, increased cancer risk, and growth retardation. Causative mutations occur in the NBS1 gene, located on human chromosome 8q21. NBS1 codes for nibrin, the key regulator protein of the R/M/N (RAD50/MRE11/NBS1) protein complex which senses and mediates cellular response to DNA DAMAGE caused by IONIZING RADIATION.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Mutation, Missense: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)Severe Combined Immunodeficiency: Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Adverse Drug Reaction Reporting Systems: Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Acacia: A plant genus of the family FABACEAE. The gums and tanning agents obtained from Acacia are called GUM ARABIC. The common name of catechu is more often used for Areca catechu (ARECA).Pharmacovigilance: The detection of long and short term side effects of conventional and traditional medicines through research, data mining, monitoring, and evaluation of healthcare information obtained from healthcare providers and patients.Lateral Line System: Aquatic vertebrate sensory system in fish and amphibians. It is composed of sense organs (canal organs and pit organs) containing neuromasts (MECHANORECEPTORS) that detect water displacement caused by moving objects.Zebrafish: An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.Sense Organs: Specialized organs adapted for the reception of stimuli by the NERVOUS SYSTEM.Zebrafish Proteins: Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).Receptors, Lysophosphatidic Acid: A subfamily of lysophospholipid receptors with specificity for LYSOPHOSPHATIDIC ACIDS.Megakaryocyte-Erythroid Progenitor Cells: The parent cells that give rise to both cells of the MEGAKARYOCYTE and the ERYTHROCYTE lineages.Mechanoreceptors: Cells specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. Mechanoreceptor cells include the INNER EAR hair cells, which mediate hearing and balance, and the various somatosensory receptors, often with non-neural accessory structures.
... is expressed on all peripheral blood lymphocytes (PBL) including T cells, B cells, Null cell and thymocytes. It is also ... CD48 is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in ... CD48 is a member of the CD2 subfamily of the immunoglobulin superfamily (IgSF) which includes SLAM (signaling lymphocyte ... Staunton DE, Thorley-Lawson DA (December 1987). "Molecular cloning of the lymphocyte activation marker Blast-1". EMBO J. 6 (12 ...
... (ALCL) is a type of non-Hodgkin lymphoma involving aberrant T cells or null lymphocytes. It is ... Occasional examples are of null (neither T nor B) cell type. These lymphomas show immunopositivity for ALK protein in 70% of ... Also required in the diagnosis is immunophenotypic evidence that cells are T lymphocytes, such as the expression of immunologic ...
... t-lymphocyte subsets MeSH A11.118.637.555.567.622 - lymphocytes, null MeSH A11.118.637.555.567.650 - lymphocytes, tumor- ... b-lymphocyte subsets MeSH A11.118.637.555.567.550.500 - t-lymphocyte subsets MeSH A11.118.637.555.567.562 - b-lymphocytes MeSH ... cd4-positive t-lymphocytes MeSH A11.118.637.555.567.569.200.400 - t-lymphocytes, helper-inducer MeSH A11.118.637.555.567.569. ... cd8-positive t-lymphocytes MeSH A11.118.637.555.567.569.220.200 - t-lymphocytes, cytotoxic MeSH A11.118.637.555.567.569.500 - ...
... t-lymphocyte subsets MeSH A15.145.229.637.555.567.584 --- lymphocytes, null MeSH A15.145.229.637.555.567.650 --- lymphocytes, ... t-lymphocyte subsets MeSH A15.382.490.555.567.622 --- lymphocytes, null MeSH A15.382.490.555.567.650 --- lymphocytes, tumor- ... t-lymphocyte subsets MeSH A15.145.229.637.555.567.562 --- b-lymphocytes MeSH A15.145.229.637.555.567.562.450 --- b-lymphocyte ... b-lymphocyte subsets MeSH A15.382.490.555.567.550.500 --- t-lymphocyte subsets MeSH A15.382.490.555.567.562 --- b-lymphocytes ...
An increase in the number of white cells (particularly lymphocytes) in the CSF, and high levels of interferon-alpha activity ... the upregulation of retroelements in TREX1-null cells has recently been disputed. Similarly, another AGS-related gene product ... An excess of white cells, chiefly lymphocytes, was found in the cerebrospinal fluid (CSF), thus indicating an inflammatory ...
As the null mice age, a marked loss of Purkinje cells in the cerebellum results in decreased motor coordination. However, this ... PrP immune cells include haematopoietic stem cells, mature lymphoid and myeloid compartments, and certain lymphocytes; also, it ... PrP-null mice provide clues to a role in muscular physiology when subjected to a forced swimming test, which showed reduced ... Circadian rhythm is altered in null mice. Fatal familial insomnia is thought to be the result of a point mutation in PRNP at ...
After reporting a null finding from their randomized controlled trial of aspirin (acetylsalicylic acid - ASA) to prevent the ... cancers right-sided mucinous cancers adenocarcinomas in any location showing any measurable level of intraepithelial lymphocyte ...
C4 (complement 4) produces a null allele at on locus C4AQ. This locus in part of the HLA A1-B8-DR3-DQ2 haplotype (markers are ... April 1990). "A1, Cw7, B8, DR3 HLA antigen combination associated with rapid decline of T-helper lymphocytes in HIV-1 infection ... Ancestral haplotypes with C4 null alleles explain diverse HLA associations". Hum. Immunol. 29 (4): 282-95. doi:10.1016/0198- ... Null), DR3, DQ2.5. While type 1 diabetes shows an extended association on the HLA A1-B8-DR3-DQ2 haplotype, the association ...
... s make up a small proportion of the lymphocytes that can be found in an organism. Because the term null cell is no ... A null cell is a large agranular lymphocyte that is developed inside of bone marrow. Null cells lack the common characteristic ... 2009). Retrieved November 29, 2015 from http://medical-dictionary.thefreedictionary.com/null+cell Null cells at the US National ... null cell. (n.d.) Mosby's Medical Dictionary, 8th edition. ( ...
Lymphocytes are the cornerstone of the adaptive immune system. They are derived from common lymphoid progenitors. The lymphoid ... "Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation". Immunity. 5 ... a molecular control of lymphocyte development". The EMBO Journal. 15 (19): 5358-69. PMC 452279 . PMID 8895580. Schjerven, H; ...
The Il2rgtm1Wjl targeted mutationb is a complete null mutation in the gene encoding the interleukin 2 receptor gamma chain ( ... J recombination in developing T and B lymphocytes. Mice homozygous for the mutation have severely reduced numbers of mature T ... 2005). "Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human ... 2005). "Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice". Blood. 106 ...
A lymphocyte is one of the subtypes of a white blood cell in a vertebrate's immune system. Lymphocytes include natural killer ... Tumor-infiltrating lymphocytes[edit]. Main article: Tumor-infiltrating lymphocyte. In some cancers, such as melanoma and ... A lymphocyte count is usually part of a peripheral complete blood cell count and is expressed as the percentage of lymphocytes ... The formation of lymphocytes is known as lymphopoiesis. B cells mature into B lymphocytes in the bursa equivalent, which in ...
HLAs corresponding to MHC class II (DP, DM, DOA, DOB, DQ, and DR) present antigens from outside of the cell to T-lymphocytes. ... Null) to designate a specific allele at a given HLA locus. HLA loci can be further classified into MHC class I and MHC class II ... A representative cellular assay is the mixed lymphocyte culture (MLC) and used to determine the HLA class II types. The ... in particular for non-European or north East Asian populations a large number of null or blank serotypes. This was particularly ...
"Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes". Mol. Pharmacol. 75 (4): 762-73. doi: ... deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice". ... "The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation". J. Biol ... blood chemistry or in the proportion of thymocyte or lymphocyte subsets. Furthermore, the rats administered the peptide gain ...
The susceptible MHC class II RT1u haplotype on chromosome 20 and a null mutation in the GIMAP5 gene on chromosome 4. The Gimap5 ... Poussier, P., et al., Lymphopenia and abnormal lymphocyte subsets in the "BB" rat: relationship to the diabetic syndrome. ...
In the Basigin null mouse, the failure of MCTs to integrate with the membrane may be directly linked to a failure of nutrient ... expression of the monocarboxylate transporter and the responsiveness of lymphocytes. Basigin is a type I integral membrane ... resulting in loss of sight in the null animal. Basigin interacts with the fourth C-type lectin domain in the receptor Endo180 ... and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse". Investigative ...
Kv1.3 has been reported to be expressed in the inner mitochondrial membrane in lymphocytes. The apoptotic protein Bax has been ... deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice". ... DeCoursey TE, Chandy KG, Gupta S, Cahalan MD (1984). "Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis ... Matteson DR, Deutsch C (1984). "K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion". Nature. ...
... lymphocyte rich Lymphocyte-rich classical Hodgkin lymphoma Hodgkin disease, lymphocyte predominance, NOS Hodgkin disease, ... T cell and Null cell type Anaplastic large cell lymphoma, CD30+/NOS M9716/3 Hepatosplenic (gamma-delta) cell lymphoma ... lymphocyte depletion, diffuse fibrosis M9655/3 Hodgkin lymphoma, lymphocyte depletion, reticular M9659/3 Nodular lymphocyte ... lymphocyte-rich, NOS Thymoma, lymphocytic, NOS Thymoma, predominantly cortical, NOS Thymoma, organoid, NOS M8583/3 Thymoma, ...
Ko LJ, Yamamoto M, Leonard MW, George KM, Ting P, Engel JD (May 1991). "Murine and human T-lymphocyte GATA-3 factors mediate ... null embryos implicate GATA family of transcription factors". The Journal of Biological Chemistry. 277 (5): 3585-92. doi: ... Höfer T, Nathansen H, Löhning M, Radbruch A, Heinrich R (Jul 2002). "GATA-3 transcriptional imprinting in Th2 lymphocytes: a ...
There is only one null classified as A11. Associations have been observed between A11 and familial otosclerosis, pulmonary ... An involvement in cytotoxic T-lymphocytes down-regulation in Burkitt's lymphoma was subsequently discovered, More recent ... "Recognition of the Epstein-Barr virus-encoded nuclear antigens EBNA-4 and EBNA-6 by HLA-A11-restricted cytotoxic T lymphocytes ...
Mice with SCIDs have lymphocyte progenitors, but these cells are unable to survive to maturity. This results in a lack of B and ... Ito, Mamoru; Hiramatsu, Hidefumi (2002). "NOD/SCID/IL2Rγ null mouse: an excellent recipient mouse model for engraftment of ... This can lead to the development of human adaptive immune cells, such as B and T lymphocytes, within SCID mice, and for ... These mice are then infected with the virus and researchers are able to study how HIV attacks the human lymphocytes and causes ...
... organizer Nucleolus Nucleoprotein Nucleoside Nucleosome Nucleotide Nucleotide pair Nucleotides Nucleus Null allele Null ... Linkage analysis Linkage equilibrium Linkage group Linkage map Linking number Locus Lod score Lod score method Lymphocyte ...
T lymphocytes) - T lymphocyte proliferation assay - T lymphocytes - T suppressor cells - T4 cell - T4 cells (T-helper cells) - ... null cell ocular - off-label use - Office of AIDS Research (OAR) - oncology - open-label trial - opportunistic infections - ... cytotoxic T lymphocyte (CTL) DAIDS - data safety and monitoring board (DSMB) - deletion - dementia - demyelination - dendrite ... B lymphocytes (B cells) - bactericidal - bacteriostatic - bacterium - baculovirus - baseline - basophil - bDNA test - beta-2 ...
PGE1 activates T lymphocytes, inhibits smooth muscle proliferation and thrombosis, is important in gonadal function and raises ... "Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice". ...
In brucellosis, lymphocytes frequently predominate (in contrast to septic arthritis due to other bacteria, in which ... but is limited in photochemically inactive and null mutants, indicating a flavin-containing histidine kinase functions as a ...
Common variable immunodeficiency is thought to be due to a problem in the differentiation from lymphocytes to plasma cells. The ... Plasma cells are large lymphocytes with a considerable nucleus-to-cytoplasm ratio and a characteristic appearance on light ...
An ultrastructural study on the lymphocytes from peripheral blood samples from 20 healthy adult Arabian oryx (Oryx leucocoryx) ... Lymphocytes, Null. A class of lymphocytes characterized by the lack of surface markers specific for either T or B lymphocytes. ... For T-lymphocytes this occurs in the thymus and ensures that mature T-lymphocytes are self tolerant. B-lymphocytes may also ... T-lymphocytes. Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, ...
Homozygosity for the β2mnull gene was tested for by staining peripheral blood lymphocytes with FITC-conjugated anti-CD8 (GIBCO ... NOD-RIP-B7-1/β2mnull Mice Develop a Low Incidence of Accelerated Diabetes.. NODβ2mnull mice have ,1% peripheral CD8 T cells but ... The Role of Lymphocyte Subsets in Accelerated Diabetes in Nonobese Diabetic-Rat Insulin Promoter-B7-1 (NOD-RIP-B7-1) Mice. F. ... Middle) Staining from one of the two NOD-RIP-B7-1/β2mnull mice that became diabetic, showing the presence of CD4 T cells and B ...
The various immunological functions carried out by lymphocytes bearing receptors for the Fc portion of IgG (FcR) have become ... Increased subpopulation of null lymphocytes in RA detected by Facb rosettes. (Submitted for publication)Google Scholar ... I. Uptake of 125l-heat aggregated human IgG by Fc-receptor bearing lymphocytes. Ann. Rheum. Dis., 37, 343PubMedCrossRefGoogle ... A. (1977). Separation and properties of EA-rosette-forming lymphocytes in humans. Eur. J. Immunol., 7, 143PubMedCrossRefGoogle ...
TP53 null type) exhibited higher LAG3 frequencies and a shorter EFS compared to TP53 wild type. This is the first report of ... Lymphocyte activation gene 3 (LAG3) protein expression on tumor-infiltrating lymphocytes in aggressive and TP53-mutated ... Our study depicts the expression of lymphocyte activation gene 3 (LAG3) in a test cohort and a larger validation cohort, ... Arolt, C., Meyer, M., Ruesseler, V. et al. Lymphocyte activation gene 3 (LAG3) protein expression on tumor-infiltrating ...
Null cell. Myeloid *REDIRECT Template:En dash. *From a page move: This is a redirect from a page that has been moved (renamed ... Typical recognition markers for lymphocytes[3] LYMPHOCYTE CLASS FUNCTION OF LYMPHOCYTE PROPORTION PHENOTYPIC MARKER(S) ... namely the large granular lymphocytes and the small lymphocytes. Functionally distinct subsets of lymphocytes correlate with ... Types of lymphocytes. The three major types of lymphocyte are T cells, B cells and natural killer (Nk) cells ...
Conclusions- Circulating CD4+CD28null lymphocytes are increased in RA. Patients with persistent CD4+CD28null cell expansion ... Frequency of CD4+CD28null T cells in 87 patients with RA and in 33 healthy control subjects. The frequency of CD4+CD28null T ... CD28null cells.22 This may account for the finding that CD4+CD28null cells partially regain expression of CD28 in rheumatoid ... CD28null cells (n=20). Table 1 shows that patients with CD4+CD28null cell expansion were characterized by a higher frequency of ...
What is memory lymphocyte? Meaning of memory lymphocyte medical term. What does memory lymphocyte mean? ... Looking for online definition of memory lymphocyte in the Medical Dictionary? memory lymphocyte explanation free. ... Null cells, which include natural killer cells, represent a small percentage of the lymphocyte population. ... lymphocyte. (redirected from memory lymphocyte). Also found in: Dictionary, Thesaurus, Encyclopedia. lymphocyte. [lim´fo-sīt] ...
Furthermore, Ikaros-null thymocytes hyperproliferate in response to T cell receptor (TCR) signaling; within days after their ... The role of the Ikaros gene in lymphocyte development and homeostasis.. Georgopoulos K1, Winandy S, Avitahl N. ... The dominant interference activity of Ikaros isoforms unable to bind DNA and their effects in lymphocyte development suggest ... is described as a central regulator of lymphocyte differentiation. During fetal development, it is required at the earliest ...
Cytotoxic innate lymphoid natural killers (NK) and adaptive CD8+T lymphocytes (CTL) interact to elicit specific cytolytic ... Cytotoxic innate lymphoid natural killers (NK) and adaptive CD8+T lymphocytes (CTL) interact to elicit specific cytolytic ... Antibody-dependent cell-mediated cytotoxicity due to a "null" lymphoid cell. Nat New Biol. (1973) 242:111-3. doi: 10.1038/ ... Pross HF, Jondal M. Cytotoxic lymphocytes from normal donors. A functional marker of human non-T lymphocytes. Clin Exp Immunol. ...
human T lymphocyte cells;. yeast strain ΔmsrA::URA3,. yeast null mutant of peptide-methionine sulfoxide reductase gene. ... A yeast null mutant of msrA was shown to accumulate both free and protein-bound MetO, and its growth was found to be more ... The null msrA mutant and its parent strain (H9 strain: Mata ura3-52 his6 leu2) were transformed with the vector YEp351 alone ... The strain completely lacking msrA [(H9 ΔmsrA∷URA3) + YEp351] will be referred to as the null mutant (NM) strain. The NM strain ...
4 Tumor Lymphocyte Kit enables phenotyping of helper T cells, cytotoxic T cells and B cells within intact FFPE tissue sections. ... The Opal™ 4 Tumor Lymphocyte Kit enables phenotyping of helper T cells, cytotoxic T cells and B cells within intact FFPE tissue ... The Opal 4 Tumor Lymphocyte Kit includes all critical workflow reagents to enable phenotyping of helper T cells, cytotoxic T ... "Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in ...
The Opal 4 Tumor Lymphocyte Kit enables phenotyping of helper T cells, cytotoxic T cells and B cells within intact FFPE tissue ... NULL OR EMPTY CART true false Part Number. List Price. Your Price. Quantity. ... The Opal™ 4 Tumor Lymphocyte Kit enables phenotyping of helper T cells, cytotoxic T cells and B cells within intact FFPE tissue ... The Opal™ 4 Tumor Lymphocyte Kit enables phenotyping of helper T cells, cytotoxic T cells and B cells within intact FFPE tissue ...
IFN-γRnull), all T cells (NOD.TCRαnull), CD8+ T cells (NOD.CD8null), B cells (NOD.IgHnull), and T and B lymphocytes (NOD.Rag1 ... C: Diabetes incidence in female NOD.Rag1null and NOD.Rag1null.IFN-γRnull recipient mice injected i.v. with 1 × 106 purified AI4 ... Other experiments analyzed NOD.Rag1null and NOD.Rag1null.IFN-γRnull recipients receiving AI4 T cells and purified splenic CD4+ ... Rag1null.AI4 splenocytes. B: Diabetes incidence in female NOD, NOD.IFN-γRnull, and NOD.IFN-γnull recipient mice injected i.v. ...
We have generated H-2b mice with a homozygous null mutation in the granzyme (gzm) B gene. Gzm B is a neutral serine protease ... Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. ... In vitro, cytotoxic T lymphocytes (CTL) derived from gzm B-/- animals are able to induce 51Cr release from allotarget cells, ... role for the rapid induction of target cell DNA fragmentation and apoptosis by alloreactive cytotoxic T lymphocytes. ...
The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. J. Biol. Chem. 277: 3823-3828. ... Cytotoxic T lymphocytes and NK cells responsible for the immunoelimination express Fas ligand and strongly rely on the ... We report in this article that the EphB3 receptor is expressed by all tested malignant T lymphocytes, where it is usually ... EphB receptors inhibit caspase activation in malignant T lymphocytes. A-D, The anti-FasR-activating Ab was immobilized onto 24- ...
... of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a ... subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. ... This SIDI8BEE antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood lymphocytes. This ...
Targeted (Null/Knockout). Sell. selectin, lymphocyte. Selptm1Hyn. Allele Type. Gene Symbol. Gene Name. ... Mice that are homozygous null for the Sell and Selp genes are viable, fertile, normal in size and do not display any gross ... In addition, lack of Sell leads to failure of lymphocytes to enter lymph nodes and gthus to hypoplastic lymph nodes. These mice ... To generate double knockouts, ES cells heterozygote for the Selptm1Hyn and Seletm2Hyn null alleles in trans to each other were ...
... , Lymphocyte, B-Lymphocyte, B-Cell, T-Lymphocyte, T-Cell, Natural Killer Cell, NK cell, Lymphocytosis. ... those with characteristics of neither major class are called null cells.. ... t lymphocyte, t cells, t lymphocytes, t-lymphocytes, t-lymphocyte, t-cell, T Cell Lymphocyte, T lymphocyte, T cell, T-cell, T ... B-lymphocyte, b-lymphocyte, b-lymphocytes, b cell, b lymphocyte, b cells, b-cell, b lymphocytes, b-cells, Lymphocytes B, B ...
... or SLP76-null Jurkat mutants have been described previously (19, 20). For stimulations, T cells at 5 × 106/ml in RPMI ... Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. Peter Tamás, Simon ... The rapid activation of AMPK in response to Ca2+ signaling in T lymphocytes thus reveals that TCR triggering is linked to an ... These experiments reveal two distinct pathways for the regulation of AMPK in T lymphocytes. The role of AMPK is to promote ATP ...
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity 9: 367-376. ... Normal T lymphocyte development in DNA-PKcsPQR/PQR and DNA-PKcsSD/SD mice. (A) Representative flow cytometry analyses of T cell ... Next, we examined lymphocyte development in DNA-PKcsPQR/PQR and DNA-PKcsSD/SD mice. The weight and total cellularity of the ... Normal B lymphocyte development and CSR in DNA-PKcsPQR/PQR and DNA-PKcsSD/SD mice. (A) Representative flow cytometry analyses ...
... lymphocytes, but maintain a normal number of B cells, macrophages, neutrophils, mast cells and NK cells. They may be useful for ... Targeted (Null/Knockout). Allele Synonym(s). SLP-76-. Gene Symbol and Name. Lcp2, lymphocyte cytosolic protein 2. ... These Lcp2 knockout mice exhibit a complete loss of T cells and γδ-TCR+ lymphocytes, but maintain a normal number of B cells, ... In these lymphocyte cytosolic protein 2 (Lcp2) knockout mice, a neomycin resistance cassette in reverse orientation disrupts ...
What is lymphocyte-activating antigen? Meaning of lymphocyte-activating antigen medical term. What does lymphocyte-activating ... Looking for online definition of lymphocyte-activating antigen in the Medical Dictionary? lymphocyte-activating antigen ... Null cells, which include natural killer cells, represent a small percentage of the lymphocyte population. ... lymphocyte. (redirected from lymphocyte-activating antigen). Also found in: Dictionary, Thesaurus, Encyclopedia. lymphocyte. [ ...
Null mutations of the Artemis gene result in a complete absence of T and B lymphocytes that is associated with increased cell ... Variability in lymphoid phenotypes, including null versus hypomorphic mutations, is reminiscent of the consequences of null ... RAG-1 deficient mice have no mature B and T lymphocytes. Cell. 1992. 68:869-877. View this article via: PubMed CrossRef Google ... A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity. 1998. 9:367-376 ...
The clear dose-response obtained in cells with the NAT2 rapid and GSTM1 null genotypes indicates that human lymphocytes ... Lymphocytes were purified from the buffy coats of two healthy blood donors by Ficoll-Paque density separation in UNI-SEP tubes ... Susceptibility of Human Lymphocytes to 2-Nitrofluorene-Induced Gene Mutation is Strongly Dependent on Metabolic Genotypes Sai- ... The culture media and the method of studying HPRT mutant induction in human lymphocytes in vitro using the T-cell cloning assay ...
... lymphocyte homing (Kanda et al., 2008) and tumor progression (Houben and Moolenaar, 2011). Lpar1-null mice display 50% ... promotes the entry of lymphocytes into secondary lymphoid organs. Nat. Immunol. 9, 415-423. doi: 10.1038/ni1573 ...
  • It has been shown that preexposure to oxidative stress suppresses the ability of T lymphocytes to respond to mitogenic stimulation in terms of proliferation, interleukin 2 biosynthesis, and signal transduction and that N- acetyl cysteine protected them against the stress ( 13 - 15 ). (pnas.org)
  • The ability of T lymphocytes to produce cytokines in response to pathogenic organisms is crucial in inducing and maintaining effective innate as well as acquired immunity. (asm.org)
  • In patients with active rheumatoid arthritis before starting MTX, CCR2 density on circulating monocytes, CD4+ CXCR3+ and CD4+ CXCR3− T lymphocytes was increased compared with controls. (bmj.com)
  • Active chronic rheumatoid arthritis is characterised by enhanced CCR2 density on circulating monocytes and CD4+ CXCR3+ and CD4+ CXCR3− T lymphocytes. (bmj.com)
  • Atherosclerosis can be considered as a chronic inflammatory disease and is characterized by local recruitment of monocytes and lymphocytes to the vessel wall. (ahajournals.org)
  • The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. (sciencemag.org)
  • Lymphocyte-mediated cytotoxicity in vitro . (springer.com)
  • We conducted an in vitro study that clearly demonstrates that functional impact of common polymorphisms in the metabolic genes, such as N-acetyltransferase 2 (NAT2), can be easily reflected in mutant induction in the gene coding for hypoxanthineguanine phosphoribosyl transferase (HPRT) in T-lymphocytes isolated from human peripheral blood. (omicsonline.org)
  • Further, human peripheral T-lymphocytes and the in vitro HPRT gene mutation assay can be utilized to study the functional impact of common genetic polymorphisms in drug metabolism and to identify risk genotypes susceptible for drug toxicity and somatic mutations. (omicsonline.org)
  • Finally, CD151-null T lymphocytes are hyperproliferative in response to in vitro mitogenic stimulation. (asm.org)
  • Interestingly, neoplastic B-lineage lymphocytes express not only BAFF but also the receptors for BAFF, which, when ligated, can promote their cell survival in vitro ( 21 ). (aacrjournals.org)
  • Functionally distinct subsets of lymphocytes correlate with their appearance. (wikidoc.org)
  • A repertoire of membrane receptors along with a milieu of intracellular secretory molecules provide input signals to drive various transcriptional master regulators that commit lymphocyte subsets to send a certain array of outputs. (frontiersin.org)
  • Our study depicts the expression of lymphocyte activation gene 3 ( LAG3) in a test cohort and a larger validation cohort, totaling 139 SGCs. (springer.com)
  • The rapid activation of AMPK in response to Ca 2+ signaling in T lymphocytes thus reveals that TCR triggering is linked to an evolutionally conserved serine kinase that regulates energy metabolism. (rupress.org)
  • During T lymphocyte activation, triggering of the TCR stimulates phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate inositol-1,4, 5-trisphosphate (IP 3 ) and polyunsaturated diacylglycerol (DAG). (rupress.org)
  • Collectively, these results indicate that rather than marking the most proinflammatory lymphocytes in diabetes development, IFN-γ production could represent an attempted limitation of pathogenic CD8 + T-cell activation. (diabetesjournals.org)
  • Previous studies suggest that neutrophils, reflecting activation of the innate immune system, are more strongly associated with incidence of coronary heart disease (CHD) than lymphocytes, which reflect activation of the adaptive immune system. (ahajournals.org)
  • A critical event in the initiation of the adaptive immune response is the activation of T lymphocytes. (sciencemag.org)
  • We found that adhesion of lymphocytes or activation of the endothelial intercellular adhesion molecule 1 (ICAM1) led to tyrosine phosphorylation of VEC. (biologists.org)
  • CD48 antigen (Cluster of Differentiation 48) also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic activation molecule 2 (SLAMF2) is a protein that in humans is encoded by the CD48 gene. (wikipedia.org)
  • CD48 is a member of the CD2 subfamily of the immunoglobulin superfamily (IgSF) which includes SLAM (signaling lymphocyte activation molecules) proteins, such as CD84, CD150, CD229 and CD244. (wikipedia.org)
  • Design and Methods To investigate a non-mendelian genetic predisposition to large granular lymphocyte leukemia, we used a step-wise method for gene discovery. (haematologica.org)
  • Flow cytometry was employed to determine the expression of MICA within hematologic compartments, showing that the signal intensity of MICA was increased in granulocytes from neutropenic patients with large granular lymphocyte leukemia in comparison with that in controls ( P =0.033). (haematologica.org)
  • Conclusions Our results illustrate that MICA-NKG2D played a role in disease pathogenesis in the majority of patients in our cohort of cases of large granular lymphocyte leukemia and further investigation into this signaling axis may provide potent therapeutic targets. (haematologica.org)
  • We conclude that gzm B serves a critical and nonredundant role for the rapid induction of target cell DNA fragmentation and apoptosis by alloreactive cytotoxic T lymphocytes. (nih.gov)
  • The regulation of lymphocyte survival vs. programmed cell death (apoptosis) is therefore essential to the survival of the healthy organism. (babraham.ac.uk)
  • Therefore, our data demonstrate an unexpected cell-type-specific interplay between FADD and RIP1, which is critical for the regulation of apoptosis and necrosis during embryogenesis and lymphocyte function. (jefferson.edu)
  • Patients with persistent CD4+CD28 null cell expansion show preclinical atherosclerotic changes, including arterial endothelial dysfunction and carotid artery wall thickening, more significantly than patients without expansion. (ahajournals.org)
  • Lymphocytes emigrate from the circulation to target tissues through the microvascular endothelial cell (EC) barrier. (biologists.org)
  • Here we show that tyrosine phosphorylation of adherens junction vascular endothelial cadherin (VEC) is required for successful transendothelial lymphocyte migration. (biologists.org)
  • Despite the identification of an increasing number of key players involved in ICAM1-mediated endothelial signaling, downstream effectors and molecular endpoints that ultimately modulate lymphocyte migration remain elusive. (biologists.org)
  • We investigated whether intercellular junction modulation is part of the endothelial response to lymphocyte migration. (biologists.org)
  • With the dissection of two basic cytolytic mechanisms of cytotoxic T lymphocytes (CTL) ( 10 , 14 , 20 , 34 ), it has become possible to delineate the important criteria that determine direct (Ag-restricted) and bystander cytotoxicity. (asm.org)
  • A yeast null mutant of msrA was shown to accumulate both free and protein-bound MetO, and its growth was found to be more severely inhibited by H 2 O 2 treatment than was that of the wild-type parent strain ( 2 ). (pnas.org)
  • A targeting vector was designed to replace 360 bp including exon 1 and the translational start site of the lymphocyte cytosolic protein 2 ( Lcp2 ) gene with a neomycin resistance (neo) cassette in reverse orientation to the gene. (jax.org)
  • Microscopically, in a Wright's stained peripheral blood smear , a normal lymphocyte has a large, dark-staining nucleus with little to no basophilic cytoplasm. (wikidoc.org)
  • In the same group, we have found that carriers of the CYP2E1 variant allele had decreased WBC and lymphocytes. (hindawi.com)
  • To test whether dietary responsiveness is involved, a congenic strain of C3H carrying an apoE-null allele (apoE −/− ) was constructed. (ahajournals.org)
  • Previous studies have shown that T lymphocytes reactive to C pneumoniae as well as chlamydial and hHSP60 and ox-LDL are present within atherosclerotic tissue. (ahajournals.org)
  • T & B Lymphocyte Identification with Monoclonal Antibodies-Hybritech T & B Cell Reagent Set from Hybritech Inc., (1981), (4 pgs. (patents.com)
  • Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma. (perkinelmer.com)
  • Paired baseline and postdosing tumor biopsy specimens were prospectively collected from 19 patients with metastatic melanoma, including 3 patients with an objective tumor response, receiving the anti-CTLA4 antibody tremelimumab within a clinical trial with primary endpoint of quantitating CD8 + cytotoxic T-lymphocyte (CTL) infiltration in tumors. (aacrjournals.org)
  • These studies relied on the functional assessment, based on clinical score, of conditional null mouse mutants lacking S1P 1 in CNS cell lineages and challenged by experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. (pnas.org)
  • It is not known whether intestinal T lymphocytes exhibit similar functional defects. (asm.org)
  • Functional complementation between FADD and RIP1 in embryos and lymphocytes. (jefferson.edu)
  • Disease-protective IFN-γ could be derived from any lymphocyte source and suppressed diabetogenic CD8 + T-cell responses both directly and through an intermediary nonlymphoid cell population. (diabetesjournals.org)