Dibutyryl Cyclic GMP: N-(1-Oxobutyl)-cyclic 3',5'-(hydrogen phosphate)-2'-butanoate guanosine. A derivative of cyclic GMP. It has a higher resistance to extracellular and intracellular phosphodiesterase than cyclic GMP.Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)Bucladesine: A cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed)Nucleotides, CyclicCyclic AMP: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.Nucleotides: The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Pentaerythritol Tetranitrate: A vasodilator with general properties similar to NITROGLYCERIN but with a more prolonged duration of action. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1025)Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.Isosorbide Dinitrate: A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.Guanylate Cyclase: An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.Nitrate Reductase: An enzyme that catalyzes the oxidation of nitrite to nitrate. It is a cytochrome protein that contains IRON and MOLYBDENUM.Pancreas: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.Acinar Cells: Cells lining the saclike dilatations known as acini of various glands or the lungs.Pancreas, Exocrine: The major component (about 80%) of the PANCREAS composed of acinar functional units of tubular and spherical cells. The acinar cells synthesize and secrete several digestive enzymes such as TRYPSINOGEN; LIPASE; AMYLASE; and RIBONUCLEASE. Secretion from the exocrine pancreas drains into the pancreatic ductal system and empties into the DUODENUM.Amylases: A group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans. (Stedman, 25th ed) EC 3.2.1.-.Cholecystokinin: A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.Gene Library: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.Ceruletide: A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.Protoplasts: The protoplasm and plasma membrane of plant, fungal, bacterial or archaeon cells without the CELL WALL.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Tobacco: A plant genus of the family SOLANACEAE. Members contain NICOTINE and other biologically active chemicals; its dried leaves are used for SMOKING.Plants, Toxic: Plants or plant parts which are harmful to man or other animals.Second Messenger Systems: Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system.Dianthus: A plant genus of the family CARYOPHYLLACEAE. Members contain dianthins, which are ribosome inactivating proteins.Plant Roots: The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)Indoleacetic Acids: Acetic acid derivatives of the heterocyclic compound indole. (Merck Index, 11th ed)Phthalimides: The imide of phthalic acids.Plant Structures: The parts of plants, including SEEDS.Ethylenes: Derivatives of ethylene, a simple organic gas of biological origin with many industrial and biological use.Cotyledon: A part of the embryo in a seed plant. The number of cotyledons is an important feature in classifying plants. In seeds without an endosperm, they store food which is used in germination. In some plants, they emerge above the soil surface and become the first photosynthetic leaves. (From Concise Dictionary of Biology, 1990)United States National Aeronautics and Space Administration: An independent Federal agency established in 1958. It conducts research for the solution of problems of flight within and outside the Earth's atmosphere and develops, constructs, tests, and operates aeronautical and space vehicles. (From U.S. Government Manual, 1993)National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Surgical Mesh: Any woven or knit material of open texture used in surgery for the repair, reconstruction, or substitution of tissue. The mesh is usually a synthetic fabric made of various polymers. It is occasionally made of metal.United StatesNational Health Insurance, United StatesPolypropylenes: Propylene or propene polymers. Thermoplastics that can be extruded into fibers, films or solid forms. They are used as a copolymer in plastics, especially polyethylene. The fibers are used for fabrics, filters and surgical sutures.MEDLARS: A computerized biomedical bibliographic storage and retrieval system operated by the NATIONAL LIBRARY OF MEDICINE. MEDLARS stands for Medical Literature Analysis and Retrieval System, which was first introduced in 1964 and evolved into an online system in 1971 called MEDLINE (MEDLARS Online). As other online databases were developed, MEDLARS became the name of the entire NLM information system while MEDLINE became the name of the premier database. MEDLARS was used to produce the former printed Cumulated Index Medicus, and the printed monthly Index Medicus, until that publication ceased in December 2004.Sporozoites: The product of meiotic division of zygotes in parasitic protozoa comprising haploid cells. These infective cells invade the host and undergo asexual reproduction producing MEROZOITES (or other forms) and ultimately gametocytes.ArchivesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Plasmodium berghei: A protozoan parasite of rodents transmitted by the mosquito Anopheles dureni.Calcium Channels, L-Type: Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Calcium Channel Agonists: Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.Calcium Channel Blockers: A class of drugs that act by selective inhibition of calcium influx through cellular membranes.Calcium Channels: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
... guanine nucleotides MeSH D13.695.667.454.160 --- cyclic gmp MeSH D13.695.667.454.160.325 --- dibutyryl cyclic gmp MeSH D13.695. ... guanine nucleotides MeSH D13.695.827.426.160 --- cyclic gmp MeSH D13.695.827.426.160.325 --- dibutyryl cyclic gmp MeSH D13.695. ... cyclic cmp MeSH D13.695.462.275 --- cyclic gmp MeSH D13.695.462.275.325 --- dibutyryl cyclic gmp MeSH D13.695.462.300 --- ... inosine nucleotides MeSH D13.695.667.616.300 --- cyclic imp MeSH D13.695.667.616.400 --- inosine diphosphate MeSH D13.695. ...
Kaupp UB, Seifert R (July 2002). "Cyclic nucleotide-gated ion channels". Physiol. Rev. 82 (3): 769-824. CiteSeerX 10.1.1.319. ... bucladesine (dibutyryl cAMP, db cAMP) - also a phosphodiesterase inhibitor. *pertussis toxin, which increases cAMP levels by ... 3',5'-cyclic-GMP phosphodiesterase. *Protein kinase G. *G alpha subunit Gα *GNAO1 ... catalyzes the conversion of ATP into cyclic adenosine monophosphate (cAMP).[8] Increases in concentration of the second ...
Krause EG, Halle W, Wollenberger A. Effect of dibutyryl cyclic GMP on cultured beating rat heart cells. Adv Cyclic Nucleotide ... of the frog ventricle to dibutyryl cyclic AMP and 8-bromo-cyclic GMP and related changes in endogenous cyclic nucleotide levels ... Hartzell HC, Fischmeister R. Opposite effects of cyclic AMP and cyclic GMP on Ca2+ current in single heart cells. Nature. 1986; ... Effects of nitrovasodilators on platelet cyclic nucleotide levels in rabbit blood: role for cyclic AMP in synergistic ...
... guanine nucleotides MeSH D13.695.667.454.160 --- cyclic gmp MeSH D13.695.667.454.160.325 --- dibutyryl cyclic gmp MeSH D13.695. ... guanine nucleotides MeSH D13.695.827.426.160 --- cyclic gmp MeSH D13.695.827.426.160.325 --- dibutyryl cyclic gmp MeSH D13.695. ... cyclic cmp MeSH D13.695.462.275 --- cyclic gmp MeSH D13.695.462.275.325 --- dibutyryl cyclic gmp MeSH D13.695.462.300 --- ... inosine nucleotides MeSH D13.695.667.616.300 --- cyclic imp MeSH D13.695.667.616.400 --- inosine diphosphate MeSH D13.695. ...
... assessment from the actions of cyclic nucleotides, British Journal of Pharmacology" on DeepDyve, the largest online rental ... dibutyryl cyclic AMP (db cyclic AMP) and 8‐bromo cyclic GMP (8‐Br cyclic GMP) on intact muscle tissue, and of cyclic AMP and ... dibutyryl cyclic AMP (db cyclic AMP) and 8‐bromo cyclic GMP (8‐Br cyclic GMP) on intact muscle tissue, and of cyclic AMP and ... Both cyclic AMP with cyclic AMP‐PK and cyclic GMP with cyclic GMP‐PK inhibit the phosphorylation of myosin. Consequently both ...
... specifically it GMP a n d for acts that I-labeled cyclic mechanism cyclic compounds nucleotides, binding the of Recently, ... receptor benzotript, binding dibutyryl However, dibutyryl the al be interpretation with and the of shown very competitively CCK ... membrane of GMP GMP phorbol-13-acetate, cyclic cell cyclic - largely presence cyclic Gunther elevated secretion. acinar 21 by ... from is cyclic GMP Exogenous in vitro 1976). GMP 1 to 2 min cyclic from a concentration GMP is (Christophe et concentration ...
8-brom-cyclic GMP. [Ca2+]cyt. cytosolic Ca2+ concentration. db-cAMP. 2′-O-dibutyryl AMP. db-cGMP. 2′-O-dibutyryl GMP. DDOA. 2′, ... Cyclic-nucleotide-mediated elevations in [Ca2+]cyt involved both internal and external Ca2+ stores. Both cAMP- and cGMP- ... Addition of membrane-permeable cyclic GMP (cGMP) and cyclic AMP (cAMP) were shown to cause elevation of cytosolic Ca2+ ... Figure 3 shows a dose-response curve for cyclic-nucleotide concentration plotted against peak [Ca2+]cyt values as a result of ...
It has been suggested that cyclic nucleotides (cAMP and cGMP) participate in the regulation of cardiac contractility and ... Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: The yin yang hypothesis. Adv. Cyclic Nucleotide ... Dibutyryl cyclic AMP and adrenaline increase contractile force and 45Ca uptake in mammalian cardiac muscle. Naunyn ... Cyclic nucleotides in acute myocardial ischemia and hypoxia. Adv. Cyclic Nucleotide Res. 12:49-61.PubMedGoogle Scholar ...
Pharmacol., 47, 330 - 339 (1995), "Characterization of Cyclic Nucleotide Phosphodiesterases With Cyclic GMP Analogs: Topology ... Recommendable alternative to unsuitable analogues such as dibutyryl cGMP. Detailed technical information and updated reference ... "Cyclic GMP-Binding Cyclic GMP-specific Phosphodiesterase from Lung". *234. Wolfe L., Corbin J. D.Francis S. H., J. Biol. Chem. ... Chem., 274, 34301 - 34309 (1999), "Activation of Mitogen-Activated Protein Kinase Pathways by Cyclic GMP and Cyclic GMP- ...
Influence of light on cyclic nucleotide metabolism in plants: effect of dibutyryl cyclic nucleotides on chloroplast components ... Durner J, Wendehenne D, Klessig D (1998) Defense gene induction in tobacco by nitric oxide, cyclic GMP and cyclic ADP-ribose. ... Nitric Oxide and Cyclic GMP Are Messengers in the Indole Acetic Acid-Induced Adventitious Rooting Process. Gabriela Carolina ... Cyclic GMP is required for IAA- and NO-mediated adventitious root formation. Non-depleted explants were treated as indicated. A ...
... cyclic GMP accumulation, and visual cell degeneration in early-onset inherited blindness, in: "Advances in Cyclic Nucleotide ... Babich, G.L., and Foret, J.E., 1973, Effects of dibutyryl cyclic AMP and related compounds on newt limb regeneration blastemas ... Friedman, D.L., 1982, Regulation of the cell cycle and cellular proliferation by cyclic nucleotides, in: "Cyclic Nucleotides II ... McLaughlin, H.M.G., Rathbone, M.P., Liversage R.A., and D.S. McLaughlin, 1983, Levels of cyclic GMP and of cyclic AMP in ...
Dibutyryl cyclic AMP and dibutyryl cyclic GMP caused a concentration-dependent relaxation of the LES smooth muscle tone, which ... Regulatory role of cyclic nucleotides in non-adrenergic non-cholinergic relaxation of lower esophageal sphincter from dogs ... Cyclic GMP , Deglutition , Dibutyryl Cyclic GMP , Dogs , Esophageal Sphincter, Lower , Ethylmaleimide , Guanethidine , ... cyclic monophosphate (cyclic AMP) and guanosine 3,5-cyclic monophosphate (cyclic GMP) via activation of adenylate cyclase and ...
Dibutyryl Cyclic GMP D3.438.759.646.454.160.325 D3.633.100.759.646.454.160.325 Dicloxacillin D3.438.260.825.625.150.205 D3.633. ... D3.633.100.759.646.454.160 Cyclic IMP D3.438.759.646.616.300 D3.633.100.759.646.616.300 Cyclic Nucleotide-Gated Cation Channels ... Cyclic AMP D3.438.759.646.138.395 D3.633.100.759.646.138.395 Cyclic GMP D3.438.759.646.454.160 ... Cyclic Nucleotide 3-Phosphodiesterase D12.776.641.580.124 D12.776.631.580.124 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- ...
Considerably higher resistance against cyclic nucleotide phosphodiesterases compared to dibutyryl- or 8-Br-cAMP (Cat. No. ,a ... Activator of protein kinase A (cyclic AMP agonist). ... "Photoaffinity Labelling of Cyclic GMP-binding Proteins in Human ... "Cyclic Nucleotide Analogs as Tools to Investigate Cyclic Nucleotide Signaling". *50. Yin W., Mu J.Birnbaum M. J., J. Biol. Chem ... Activator of protein kinase A (cyclic AMP agonist). Considerably higher resistance against cyclic nucleotide phosphodiesterases ...
MeSH D13.695.667.454.160.325 --- dibutyryl cyclic gmp * MeSH D13.695.667.454.200 --- deoxyguanine nucleotides ... MeSH D13.695.462 --- nucleotides, cyclic. * MeSH D13.695.462.200 --- cyclic amp * MeSH D13.695.462.200.225 --- 8-bromo cyclic ... MeSH D13.695.667 --- purine nucleotides. * MeSH D13.695.667.138 --- adenine nucleotides * MeSH D13.695.667.138.124 --- ... MeSH D13.695.740 --- pyrimidine nucleotides. * MeSH D13.695.740.050 --- apurinic acid * MeSH D13.695.740.246 --- cytosine ...
In this sense, the discovery of substances that act by tilting the cyclic AMP/ cyclic GMP balance and/or function in primary ... Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels of the second messengers, cAMP and ... direct blockade of ongoing mechanical hyperalgesia has been observed after local administration of dibutyryl cGMP or substances ... Modulation of cyclic nucleotide levels by changes in particulate cGMP hydrolysis may produce development of complete tolerance ...
Juilfs, D. M., Soderling, S., Burns, F., and Beavo, J. A. (1999). Cyclic GMP as substrate and regulator of cyclic nucleotide ... Weill, C. L., and Greene, D. P. (1984). Prevention of natural motoneurone cell death by dibutyryl cyclic GMP. Nature 308, 452- ... Abraham, R. Z., Kobzik, L., Moody, M. R., Reid, M. B., and Stamler, J. S. (1998). Cyclic GMP is a second messenger by which ... Fiscus, R. R. (2002). Involvement of cyclic GMP and protein kinase G in the regulation of apoptosis and survival in neural ...
Inhibition of cyclic GMP hydrolysis with zaprinast reduces basal and cyclic AMP-elevated L-type calcium current in guinea-pig ... cyclic nucleotide phosphodiesterase. Gene. 1998;216:139-147. [PubMed]. *Lovett JL, Sibley LD. Intracellular calcium stores in ... Finally, we used a cell-permeant cAMP agonist, dibutyryl cAMP, to emulate the effects of cAMP. All of these initiated ... However, Zaprinast, an inhibitor of cyclic GMP-specific PDE failed to initiate sporozoite motility in the absence of albumin, ...
... by cyclic nucleotides could be referable to phosphorylation of different regulatory sites on the α1c subunit. ... ACh opposed the action of ISO or dibutyryl-cAMP on the inwardly rectifying K+ current by activation of okadaic acid-sensitive ... 2001) Cyclic GMP regulation of the L-type Ca2+ channel current in human atrial myocytes. J Physiol 533:329-340. ... On the Role of Phosphatase in Regulation of Cardiac L-Type Calcium Current by Cyclic GMP. Jian-Bing Shen and Achilles J. ...
Development of tolerance to glyceryl trinitrate in an isolated human peripheral vein and its relation to cyclic GMP metabolism ... Dibutyryl Cyclic AMP and Forskolin Inhibit Phosphatidylinositol Hydrolysis, Ca2+ Influx and Contraction in Vascular Smooth ... J. Cyclic Nucleotide Prot. Phosphoryl. Res. 9, 415-425, 1983 被引用文献2件 ... Relaxation of hormonally stimulated smooth muscular tissues by the 8-bromo derivative of cyclic GMP SCHULTZ KD. ...
These purine cyclic nucleotides activate PKA and PKG, respectively. So far, there was no evidence of further cyclic nucleotides ... cyclic AMP or 3:5- cyclic GMP. J Biol Chem. 1978, 253: 2522-2524.PubMedGoogle Scholar. ... Ervens J, Seifert R: Differential modulation by N4, 2-O-dibutyryl cytidine 3:5-cyclic monophosphate of neutrophil activation ... Meanwhile the existence of cCMP was described [1]. Formation of the cyclic pyrimidine nucleotide cyclic cytidine 3,5- ...
The regulatory domain contains two non-identical binding sites for cyclic nucleotides (cNMPs), i.e., a slowly exchanging and a ... Hofmann F: The biology of cyclic GMP-dependent protein kinases. J Biol Chem. 2005, 280: 1-4. ... 5], the membrane-permeable cCMP analogue dibutyryl-cCMP (DB-cCMP) induces smooth muscle relaxation and activates PKGI in aortic ... dependent protein kinases by cyclic purine and pyrimidine nucleotides. Biochem Biophys Res Commun. 2011, 415: 563-565. 10.1016/ ...
Definition of Dibutyryl cyclic AMP with photos and pictures, translations, sample usage, and additional links for more ... dibutyryl cyclic AMP (current term). dibutyryl cyclic GMP. dicacious. dicacity. dicacodyl. dicaesium. dicalcic. dicalcium. ... 1. An analogue of cyclic AMP that shares some of the pharmacological effects of this nucleotide, but is generally believed to ... Dibutyryl Cyclic AMP Images Lexicographical Neighbors of Dibutyryl Cyclic AMP. dibromopropamidine isethionate. ...
Brooker G. Dissociation of cyclic GMP from the negative inotropic action of carbachol in guinea pig atria. J Cyclic Nucleotide ... Endoh M, Shimizu T. Failure of dibutyryl-cAMP and 8-bromo-cGMP to mimic the antagonistic actions of carbachol on the positive ... Cyclic changes in levels of cyclic AMP and cyclic GMP in frog myocardium during the cardiac cycle. Biochem Biophys Res Commun. ... A novel cyclic GMP-lowering agent, LY83583, blocks carbachol-induced cyclic GMP elevation in rabbit atrial strips without ...
Role of cyclic AMP and cyclic GMP. Biochim Biophys Acta. 1975 Dec 05; 411(2):250-62. View abstract ... The influence of epinephrine and dibutyryl cyclic adenosine 3,5-monophosphate. J Biol Chem. 1969 Oct 25; 244(20):5608-15. ... Keane NE, Molloy DP, Grand RJ, Owen D, Levine BA, Ellis L. Peptide mimetics of nucleotide phosphate binding sites. Biochem Soc ... Conformational changes occurring in N-ras p21 in response to binding of guanine nucleotide and metal ions probed by proteolysis ...
The mechanism by which dibutyryl cyclic GMP antagonizes the action of cholecystokinin. Gastroenterology. 1983; 84:1637-1639. ... The gall bladder cholecystokinin receptor exists in two guanine nucleotide-binding protein-regulated affinity states. Mol ... A soluble interaction between dibutyryl cyclic guanosine 3:5-monophosphate and cholecystokinin: a possible mechanism for the ... Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally constrained cyclic ...
The Cyclic AMP (cAMP) Direct Immunoassay kit is designed to measure cAMP present in lysed cells, tissue, plasma, urine, saliva ... Levels of cyclic AMP and cyclic GMP in porcine oocyte cumulus complexes and cumulus free oocytes derived from small and middle ... Cyclic Nucleotide (cAMP and cGMP) Assays and Capture ELISA for Quantitative Analysis of Plasmodium falciparum Blood-stage ... Induction of peptidylarginine deiminase 2 and 3 by dibutyryl cAMP via cAMP-PKA signaling in human astrocytoma U-251MG cells. ...
  • Functional significance of single nucleotide polymorphisms in the lactase gene in diverse US patients and evidence for a novel lactase persistence allele at -13909 in those of European ancestry. (childrenshospital.org)
  • An iSelect platform assay containing 5,744 oat single nucleotide polymorphisms was used to genotype the populations. (saladgaffe.ga)
  • The DetectX ® Cyclic AMP (cAMP) Direct Immunoassay kit is designed to quantitatively measure cAMP present in lysed cells, tissue, plasma, urine, saliva and culture media samples. (arborassays.com)
  • In vitro , differentiation of the LNCaP and PC3M prostatic tumor cell lines to a NE phenotype can be induced by dibutyryl cyclic AMP (cAMP), suggesting that physiological agents that increase intracellular concentrations of cAMP might regulate NE differentiation in vivo . (aacrjournals.org)
  • Indeed, we demonstrate in this report that LNCaP cells acquire NE characteristics in response to treatment with physiological and pharmacological agents that elevate intracellular cAMP, agents such as epinephrine, isoproterenol, forskolin, and dibutyryl cAMP. (aacrjournals.org)
  • C-G) Naive CD4 + T cells were activated with anti-CD3/CD28/CD2 beads and cultured for 11 d in the presence or absence of PGE2, dibutyryl-cAMP, or specific EP receptor agonists. (nih.gov)
  • 1. A composition comprising an agent selected from a cyclic AMP (cAMP) enhancer and a ligand to a prostaglandin EP receptor, and an organic solvent, wherein the agent or the organic solvent are contained within a sterile and endotoxin free vessel, and wherein the composition is suitable for ex vivo administration to human cells. (patentsencyclopedia.com)
  • Provided are improved pharmaceutical compositions that comprise ligands or agonists to prostaglandin EP receptors, and/or cyclic AMP enhancers, and suitable organic solvents that are substantially free of methyl acetate, the compositions being provided for storage and/or use in an endotoxin-free vessel, such as a tube or PE bag. (patentsencyclopedia.com)
  • 1. An analogue of cyclic AMP that shares some of the pharmacological effects of this nucleotide, but is generally believed to enter cells more readily on account of its greater hydrophobicity. (lexic.us)
  • Taken together, these data suggest that a potential communication point for cross-talk between signal transduction pathways using cyclic nucleotides in plants is at the level of Ca 2+ signaling. (plantphysiol.org)
  • In human purified naive T cells, PGE2 acts via prostaglandin receptor EP2- and EP4-mediated signaling and cyclic AMP pathways to up-regulate IL-23 and IL-1 receptor expression. (nih.gov)
  • When the effects of isoprenaline or db cyclic AMP were observed, both agents inhibited the caffeine‐induced contraction but the accumulation of Ca into cells was greater than the control. (deepdyve.com)
  • Bradykinin inhibition of cyclic AMP accumulation in D384 astrocytoma cells. (nih.gov)
  • The main effect of cyclic GMP is activation of Ca extrusion, thus reducing the amount of Ca stored in the cell, while the main effect of cyclic AMP is to increase the amount of Ca stored in the cell. (deepdyve.com)
  • Rixon, R.H., and Whitfield, J.F., 1985, The Possible cyclic AMP-dependence of an early prereplicative event that determines mitosis in regenerating rat liver, J. Cell. (springer.com)
  • It is now possible to analyze hormonal effects on gene expression and to study which few nucleotides of the 3×109 in each haploid genome confer the response. (wordpress.com)
  • First, we found that cone noise was not dominated by spontaneous photopigment activation or by quantal fluctuations in photon absorption, but was instead dominated by other sources, namely channel noise and fluctuations in cyclic GMP. (nih.gov)