Nuclear Proteins
Cell Nucleus
Molecular Sequence Data
Base Sequence
DNA-Binding Proteins
Promoter Regions, Genetic
Amino Acid Sequence
ran GTP-Binding Protein
Transcription Factors
Transcription, Genetic
HeLa Cells
DNA
Nucleoplasmins
Protein Binding
Nuclear Localization Signals
Binding Sites
Regulatory Sequences, Nucleic Acid
Gene Expression Regulation
Active Transport, Cell Nucleus
Deoxyribonuclease I
Enhancer Elements, Genetic
Nuclear Envelope
Karyopherins
Cloning, Molecular
Transfection
Recombinant Fusion Proteins
RNA, Messenger
Cytoplasm
Epstein-Barr Virus Nuclear Antigens
Histones
alpha Karyopherins
Sequence Homology, Amino Acid
Nuclear Pore Complex Proteins
Chromosomal Proteins, Non-Histone
Mutation
Sp1 Transcription Factor
Tumor Cells, Cultured
RNA-Binding Proteins
beta Karyopherins
Chromatin
Electrophoresis, Polyacrylamide Gel
Nuclear Matrix
Transcriptional Activation
Oligodeoxyribonucleotides
Chloramphenicol O-Acetyltransferase
Electrophoretic Mobility Shift Assay
Poly Adenosine Diphosphate Ribose
Nuclear Matrix-Associated Proteins
DNA, Complementary
DNA Footprinting
Plasmids
Liver
Cells, Cultured
Heterogeneous-Nuclear Ribonucleoproteins
Restriction Mapping
Sequence Homology, Nucleic Acid
Protamines
Repetitive Sequences, Nucleic Acid
Carrier Proteins
Zinc Fingers
Oligonucleotide Probes
Nucleocytoplasmic Transport Proteins
High Mobility Group Proteins
Two-Hybrid System Techniques
Trans-Activators
Repressor Proteins
Consensus Sequence
Genes, Reporter
Poly(ADP-ribose) Polymerases
DNA Primers
Fluorescent Antibody Technique
Sequence Alignment
Gene Expression
Mutagenesis, Site-Directed
Blotting, Western
Protein Structure, Tertiary
Heterogeneous-Nuclear Ribonucleoprotein Group A-B
Immunoglobulin J Recombination Signal Sequence-Binding Protein
Genes
Nuclear Pore
Binding, Competitive
Phosphorylation
COS Cells
CCAAT-Enhancer-Binding Proteins
Gene Expression Regulation, Enzymologic
Saccharomyces cerevisiae Proteins
Lamins
Drosophila Proteins
Proteins
Cell Cycle Proteins
Phosvitin
Saccharomyces cerevisiae
Luciferases
Oligonucleotides
Neoplasm Proteins
Microscopy, Fluorescence
Response Elements
Genes, Regulator
Receptors, Cytoplasmic and Nuclear
Cell Cycle
Cellular Apoptosis Susceptibility Protein
Cell Compartmentation
Cell Nucleolus
Blotting, Northern
Signal Transduction
Protein Transport
Methylation
Proto-Oncogene Proteins c-jun
Thymosin
Subcellular Fractions
Lamin Type B
3T3 Cells
RNA, Heterogeneous Nuclear
TATA Box
Drosophila
Biological Transport
Conserved Sequence
Chromatography, Affinity
Gene Expression Regulation, Developmental
Organ Specificity
Precipitin Tests
Herpesvirus 4, Human
Cyclic AMP Response Element-Binding Protein
Cell Division
Cell Differentiation
Plant Proteins
RNA
Immunohistochemistry
Transcription Factor AP-1
Green Fluorescent Proteins
Luminescent Proteins
Gene Library
Mitosis
NFI Transcription Factors
Proto-Oncogene Proteins
DNA Probes
Mutagenesis
Introns
Protein Kinases
Immunoblotting
Adenosine Diphosphate Sugars
Leucine Zippers
Cricetinae
RNA Splicing
Exons
Chickens
Cell Fractionation
HMGN1 Protein
Ultraviolet Rays
Electrophoresis, Gel, Two-Dimensional
NF-kappa B
HMGA1a Protein
Proto-Oncogene Proteins c-fos
Protein Processing, Post-Translational
Amino Acid Motifs
Microinjections
Thymopoietins
Xenopus
Guanosine Triphosphate
DNA Damage
Drosophila melanogaster
Fibroblasts
Polymerase Chain Reaction
Spermatids
Proto-Oncogenes
Testis
Glutathione Transferase
Fluorescent Antibody Technique, Indirect
Cercopithecus aethiops
Autoantigens
Homeodomain Proteins
Proliferating Cell Nuclear Antigen
Models, Biological
Intranuclear Inclusion Bodies
Protein Biosynthesis
Cell Line, Transformed
Blotting, Southwestern
Gene Expression Regulation, Viral
Y-Box-Binding Protein 1
Novel regulation of the homeotic gene Scr associated with a crustacean leg-to-maxilliped appendage transformation. (1/36129)
Homeotic genes are known to be involved in patterning morphological structures along the antero-posterior axis of insects and vertebrates. Because of their important roles in development, changes in the function and expression patterns of homeotic genes may have played a major role in the evolution of different body plans. For example, it has been proposed that during the evolution of several crustacean lineages, changes in the expression patterns of the homeotic genes Ultrabithorax and abdominal-A have played a role in transformation of the anterior thoracic appendages into mouthparts termed maxillipeds. This homeotic-like transformation is recapitulated at the late stages of the direct embryonic development of the crustacean Porcellio scaber (Oniscidea, Isopoda). Interestingly, this morphological change is associated with apparent novelties both in the transcriptional and post-transcriptional regulation of the Porcellio scaber ortholog of the Drosophila homeotic gene, Sex combs reduced (Scr). Specifically, we find that Scr mRNA is present in the second maxillary segment and the first pair of thoracic legs (T1) in early embryos, whereas protein accumulates only in the second maxillae. In later stages, however, high levels of SCR appear in the T1 legs, which correlates temporally with the transformation of these appendages into maxillipeds. Our observations provide further insight into the process of the homeotic leg-to-maxilliped transformation in the evolution of crustaceans and suggest a novel regulatory mechanism for this process in this group of arthropods. (+info)The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping. (2/36129)
Left-right asymmetry in vertebrates is controlled by activities emanating from the left lateral plate. How these signals get transmitted to the forming organs is not known. A candidate mediator in mouse, frog and zebrafish embryos is the homeobox gene Pitx2. It is asymmetrically expressed in the left lateral plate mesoderm, tubular heart and early gut tube. Localized Pitx2 expression continues when these organs undergo asymmetric looping morphogenesis. Ectopic expression of Xnr1 in the right lateral plate induces Pitx2 transcription in Xenopus. Misexpression of Pitx2 affects situs and morphology of organs. These experiments suggest a role for Pitx2 in promoting looping of the linear heart and gut. (+info)Requirement of a novel gene, Xin, in cardiac morphogenesis. (3/36129)
A novel gene, Xin, from chick (cXin) and mouse (mXin) embryonic hearts, may be required for cardiac morphogenesis and looping. Both cloned cDNAs have a single open reading frame, encoding proteins with 2,562 and 1,677 amino acids for cXin and mXin, respectively. The derived amino acid sequences share 46% similarity. The overall domain structures of the predicted cXin and mXin proteins, including proline-rich regions, 16 amino acid repeats, DNA-binding domains, SH3-binding motifs and nuclear localization signals, are highly conserved. Northern blot analyses detect a single message of 8.9 and 5.8 kilo base (kb) from both cardiac and skeletal muscle of chick and mouse, respectively. In situ hybridization reveals that the cXin gene is specifically expressed in cardiac progenitor cells of chick embryos as early as stage 8, prior to heart tube formation. cXin continues to be expressed in the myocardium of developing hearts. By stage 15, cXin expression is also detected in the myotomes of developing somites. Immunofluorescence microscopy reveals that the mXin protein is colocalized with N-cadherin and connexin-43 in the intercalated discs of adult mouse hearts. Incubation of stage 6 chick embryos with cXin antisense oligonucleotides results in abnormal cardiac morphogenesis and an alteration of cardiac looping. The myocardium of the affected hearts becomes thickened and tends to form multiple invaginations into the heart cavity. This abnormal cellular process may account in part for the abnormal looping. cXin expression can be induced by bone morphogenetic protein (BMP) in explants of anterior medial mesoendoderm from stage 6 chick embryos, a tissue that is normally non-cardiogenic. This induction occurs following the BMP-mediated induction of two cardiac-restricted transcription factors, Nkx2.5 and MEF2C. Furthermore, either MEF2C or Nkx2.5 can transactivate a luciferase reporter driven by the mXin promoter in mouse fibroblasts. These results suggest that Xin may participate in a BMP-Nkx2.5-MEF2C pathway to control cardiac morphogenesis and looping. (+info)Drosophila oogenesis: versatile spn doctors. (4/36129)
Recent work on Drosophila oogenesis has uncovered connections between cell-cycle checkpoints and pattern formation. Genes of the spindle class, which encode double-strand break repair enzymes and RNA helicases, affect oocyte polarity and the decision whether to differentiate as an oocyte or a nurse cell. (+info)Meiosis: MeiRNA hits the spot. (5/36129)
The protein Mei2 performs at least two functions required in fission yeast for the switch from mitotic to meiotic cell cycles. One of these functions also requires meiRNA. It appears that meiRNA targets Mei2 to the nucleus, where it can promote the first meiotic division. (+info)The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. (6/36129)
BACKGROUND: The adaptor protein Gads is a Grb2-related protein originally identified on the basis of its interaction with the tyrosine-phosphorylated form of the docking protein Shc. Gads protein expression is restricted to hematopoietic tissues and cell lines. Gads contains a Src homology 2 (SH2) domain, which has previously been shown to have a similar binding specificity to that of Grb2. Gads also possesses two SH3 domains, but these have a distinct binding specificity to those of Grb2, as Gads does not bind to known Grb2 SH3 domain targets. Here, we investigated whether Gads is involved in T-cell signaling. RESULTS: We found that Gads is highly expressed in T cells and that the SLP-76 adaptor protein is a major Gads-associated protein in vivo. The constitutive interaction between Gads and SLP-76 was mediated by the carboxy-terminal SH3 domain of Gads and a 20 amino-acid proline-rich region in SLP-76. Gads also coimmunoprecipitated the tyrosine-phosphorylated form of the linker for activated T cells (LAT) adaptor protein following cross-linking of the T-cell receptor; this interaction was mediated by the Gads SH2 domain. Overexpression of Gads and SLP-76 resulted in a synergistic augmentation of T-cell signaling, as measured by activation of nuclear factor of activated T cells (NFAT), and this cooperation required a functional Gads SH2 domain. CONCLUSIONS: These results demonstrate that Gads plays an important role in T-cell signaling via its association with SLP-76 and LAT. Gads may promote cross-talk between the LAT and SLP-76 signaling complexes, thereby coupling membrane-proximal events to downstream signaling pathways. (+info)Insect evolution: Redesigning the fruitfly. (7/36129)
Homeotic mutations in Drosophila can result in dramatic phenotypes that suggest the possibility for rapid morphological evolution, but dissection of the genetic pathway downstream of Ultrabithorax is beginning to reveal how wing morphology may have evolved by more gradual transformations. (+info)Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization. (8/36129)
The Drosophila Inscuteable protein acts as a key regulator of asymmetric cell division during the development of the nervous system [1] [2]. In neuroblasts, Inscuteable localizes into an apical cortical crescent during late interphase and most of mitosis. During mitosis, Inscuteable is required for the correct apical-basal orientation of the mitotic spindle and for the asymmetric segregation of the proteins Numb [3] [4] [5], Prospero [5] [6] [7] and Miranda [8] [9] into the basal daughter cell. When Inscuteable is ectopically expressed in epidermal cells, which normally orient their mitotic spindle parallel to the embryo surface, these cells reorient their mitotic spindle and divide perpendicularly to the surface [1]. Like the Inscuteable protein, the inscuteable RNA is asymmetrically localized [10]. We show here that inscuteable RNA localization is not required for Inscuteable protein localization. We found that a central 364 amino acid domain - the Inscuteable asymmetry domain - was necessary and sufficient for Inscuteable localization and function. Within this domain, a separate 100 amino acid region was required for asymmetric localization along the cortex, whereas a 158 amino acid region directed localization to the cell cortex. The same 158 amino acid fragment could localize asymmetrically when coexpressed with the full-length protein, however, and could bind to Inscuteable in vitro, suggesting that this domain may be involved in the self-association of Inscuteable in vivo. (+info)1. Activation of oncogenes: Some viruses contain genes that code for proteins that can activate existing oncogenes in the host cell, leading to uncontrolled cell growth.
2. Inactivation of tumor suppressor genes: Other viruses may contain genes that inhibit the expression of tumor suppressor genes, allowing cells to grow and divide uncontrollably.
3. Insertional mutagenesis: Some viruses can insert their own DNA into the host cell's genome, leading to disruptions in normal cellular function and potentially causing cancer.
4. Epigenetic changes: Viral infection can also cause epigenetic changes, such as DNA methylation or histone modification, that can lead to the silencing of tumor suppressor genes and the activation of oncogenes.
Viral cell transformation is a key factor in the development of many types of cancer, including cervical cancer caused by human papillomavirus (HPV), and liver cancer caused by hepatitis B virus (HBV). In addition, some viruses are specifically known to cause cancer, such as Kaposi's sarcoma-associated herpesvirus (KSHV) and Merkel cell polyomavirus (MCV).
Early detection and treatment of viral infections can help prevent the development of cancer. Vaccines are also available for some viruses that are known to cause cancer, such as HPV and hepatitis B. Additionally, antiviral therapy can be used to treat existing infections and may help reduce the risk of cancer development.
Examples of experimental liver neoplasms include:
1. Hepatocellular carcinoma (HCC): This is the most common type of primary liver cancer and can be induced experimentally by injecting carcinogens such as diethylnitrosamine (DEN) or dimethylbenz(a)anthracene (DMBA) into the liver tissue of animals.
2. Cholangiocarcinoma: This type of cancer originates in the bile ducts within the liver and can be induced experimentally by injecting chemical carcinogens such as DEN or DMBA into the bile ducts of animals.
3. Hepatoblastoma: This is a rare type of liver cancer that primarily affects children and can be induced experimentally by administering chemotherapy drugs to newborn mice or rats.
4. Metastatic tumors: These are tumors that originate in other parts of the body and spread to the liver through the bloodstream or lymphatic system. Experimental models of metastatic tumors can be studied by injecting cancer cells into the liver tissue of animals.
The study of experimental liver neoplasms is important for understanding the underlying mechanisms of liver cancer development and progression, as well as identifying potential therapeutic targets for the treatment of this disease. Animal models can be used to test the efficacy of new drugs or therapies before they are tested in humans, which can help to accelerate the development of new treatments for liver cancer.
Erythroleukemia typically affects adults in their 50s and 60s, although it can occur at any age. Symptoms may include fever, night sweats, weight loss, and fatigue. The cancer cells can spread to other parts of the body, including the spleen, liver, and lymph nodes.
Erythroleukemia is diagnosed through a combination of physical examination, blood tests, and bone marrow biopsy. Treatment typically involves chemotherapy and/or radiation therapy to kill cancer cells and restore normal blood cell production. In some cases, a bone marrow transplant may be necessary. The prognosis for erythroleukemia is generally poor, with a five-year survival rate of about 20%.
Erythroleukemia is classified as an acute leukemia, meaning it progresses rapidly and can lead to life-threatening complications if left untreated. It is important for patients to receive prompt and appropriate treatment to improve their chances of survival and quality of life.
There are several risk factors for developing HCC, including:
* Cirrhosis, which can be caused by heavy alcohol consumption, viral hepatitis (such as hepatitis B and C), or fatty liver disease
* Family history of liver disease
* Chronic obstructive pulmonary disease (COPD)
* Diabetes
* Obesity
HCC can be challenging to diagnose, as the symptoms are non-specific and can be similar to those of other conditions. However, some common symptoms of HCC include:
* Yellowing of the skin and eyes (jaundice)
* Fatigue
* Loss of appetite
* Abdominal pain or discomfort
* Weight loss
If HCC is suspected, a doctor may perform several tests to confirm the diagnosis, including:
* Imaging tests, such as ultrasound, CT scan, or MRI, to look for tumors in the liver
* Blood tests to check for liver function and detect certain substances that are produced by the liver
* Biopsy, which involves removing a small sample of tissue from the liver to examine under a microscope
Once HCC is diagnosed, treatment options will depend on several factors, including the stage and location of the cancer, the patient's overall health, and their personal preferences. Treatment options may include:
* Surgery to remove the tumor or parts of the liver
* Ablation, which involves destroying the cancer cells using heat or cold
* Chemoembolization, which involves injecting chemotherapy drugs into the hepatic artery to reach the cancer cells
* Targeted therapy, which uses drugs or other substances to target specific molecules that are involved in the growth and spread of the cancer
Overall, the prognosis for HCC is poor, with a 5-year survival rate of approximately 20%. However, early detection and treatment can improve outcomes. It is important for individuals at high risk for HCC to be monitored regularly by a healthcare provider, and to seek medical attention if they experience any symptoms.
Also known as Burkitt's Lymphoma.
The symptoms of choriocarcinoma can vary depending on the location and size of the tumor, but they may include:
* Abnormal vaginal bleeding
* Pelvic pain
* Abdominal pain
* Weakness and fatigue
* Shortness of breath
* Nausea and vomiting
If choriocarcinoma is suspected, a variety of tests may be performed to confirm the diagnosis. These may include:
* Ultrasound: This imaging test uses high-frequency sound waves to create pictures of the uterus and ovaries. It can help doctors identify any abnormal growths or tumors in the area.
* Hysteroscopy: This procedure involves inserting a thin, lighted tube through the cervix to visualize the inside of the uterus. Doctors may use hysteroscopy to collect samples of tissue for testing.
* Laparoscopy: This procedure involves making small incisions in the abdomen and using a thin, lighted tube to visualize the inside of the pelvis. Doctors may use laparoscopy to collect samples of tissue for testing or to remove any tumors that are found.
* Biopsy: In this test, doctors take a small sample of tissue from the uterus and examine it under a microscope for cancer cells.
If choriocarcinoma is confirmed, treatment may involve a combination of surgery, chemotherapy, and radiation therapy. The specific treatment plan will depend on the stage and location of the cancer, as well as the patient's overall health.
Prognosis for choriocarcinoma varies depending on the stage of the cancer when it is diagnosed. In general, the prognosis is good if the cancer is caught early and treated promptly. However, if the cancer has spread to other parts of the body (metastasized), the prognosis may be poorer.
It's important for women who have had a molar pregnancy or choriocarcinoma to follow up with their healthcare provider regularly to ensure that any remaining tissue is removed and to monitor for any signs of recurrence.
Liver neoplasms, also known as liver tumors or hepatic tumors, are abnormal growths of tissue in the liver. These growths can be benign (non-cancerous) or malignant (cancerous). Malignant liver tumors can be primary, meaning they originate in the liver, or metastatic, meaning they spread to the liver from another part of the body.
There are several types of liver neoplasms, including:
1. Hepatocellular carcinoma (HCC): This is the most common type of primary liver cancer and arises from the main cells of the liver (hepatocytes). HCC is often associated with cirrhosis and can be caused by viral hepatitis or alcohol abuse.
2. Cholangiocarcinoma: This type of cancer arises from the cells lining the bile ducts within the liver (cholangiocytes). Cholangiocarcinoma is rare and often diagnosed at an advanced stage.
3. Hemangiosarcoma: This is a rare type of cancer that originates in the blood vessels of the liver. It is most commonly seen in dogs but can also occur in humans.
4. Fibromas: These are benign tumors that arise from the connective tissue of the liver (fibrocytes). Fibromas are usually small and do not spread to other parts of the body.
5. Adenomas: These are benign tumors that arise from the glandular cells of the liver (hepatocytes). Adenomas are usually small and do not spread to other parts of the body.
The symptoms of liver neoplasms vary depending on their size, location, and whether they are benign or malignant. Common symptoms include abdominal pain, fatigue, weight loss, and jaundice (yellowing of the skin and eyes). Diagnosis is typically made through a combination of imaging tests such as CT scans, MRI scans, and ultrasound, and a biopsy to confirm the presence of cancer cells.
Treatment options for liver neoplasms depend on the type, size, location, and stage of the tumor, as well as the patient's overall health. Surgery may be an option for some patients with small, localized tumors, while others may require chemotherapy or radiation therapy to shrink the tumor before surgery can be performed. In some cases, liver transplantation may be necessary.
Prognosis for liver neoplasms varies depending on the type and stage of the cancer. In general, early detection and treatment improve the prognosis, while advanced-stage disease is associated with a poorer prognosis.
Some common effects of chromosomal deletions include:
1. Genetic disorders: Chromosomal deletions can lead to a variety of genetic disorders, such as Down syndrome, which is caused by a deletion of a portion of chromosome 21. Other examples include Prader-Willi syndrome (deletion of chromosome 15), and Williams syndrome (deletion of chromosome 7).
2. Birth defects: Chromosomal deletions can increase the risk of birth defects, such as heart defects, cleft palate, and limb abnormalities.
3. Developmental delays: Children with chromosomal deletions may experience developmental delays, learning disabilities, and intellectual disability.
4. Increased cancer risk: Some chromosomal deletions can increase the risk of developing certain types of cancer, such as chronic myelogenous leukemia (CML) and breast cancer.
5. Reproductive problems: Chromosomal deletions can lead to reproductive problems, such as infertility or recurrent miscarriage.
Chromosomal deletions can be diagnosed through a variety of techniques, including karyotyping (examination of the chromosomes), fluorescence in situ hybridization (FISH), and microarray analysis. Treatment options for chromosomal deletions depend on the specific effects of the deletion and may include medication, surgery, or other forms of therapy.
Explanation: Neoplastic cell transformation is a complex process that involves multiple steps and can occur as a result of genetic mutations, environmental factors, or a combination of both. The process typically begins with a series of subtle changes in the DNA of individual cells, which can lead to the loss of normal cellular functions and the acquisition of abnormal growth and reproduction patterns.
Over time, these transformed cells can accumulate further mutations that allow them to survive and proliferate despite adverse conditions. As the transformed cells continue to divide and grow, they can eventually form a tumor, which is a mass of abnormal cells that can invade and damage surrounding tissues.
In some cases, cancer cells can also break away from the primary tumor and travel through the bloodstream or lymphatic system to other parts of the body, where they can establish new tumors. This process, known as metastasis, is a major cause of death in many types of cancer.
It's worth noting that not all transformed cells will become cancerous. Some forms of cellular transformation, such as those that occur during embryonic development or tissue regeneration, are normal and necessary for the proper functioning of the body. However, when these transformations occur in adult tissues, they can be a sign of cancer.
See also: Cancer, Tumor
Word count: 190
Nuclear protein
Nuclear magnetic resonance spectroscopy of proteins
Transition nuclear protein
Inner nuclear membrane protein
Nuclear protein in testis gene
Nuclear pore complex protein Nup133
Nuclear cap-binding protein complex
Sp140 nuclear body protein like
Nuclear mitotic apparatus protein 1
Myeloid and erythroid nuclear termination stage-specific protein
Nuclear factor of activated t cells 2 interacting protein
Protein O-GlcNAc transferase
RNA-binding protein
Non-POU domain-containing octamer-binding protein
Deficiency of RbAp48 protein and memory loss
Autophagy-related protein 101
5-lipoxygenase-activating protein
Gem-associated protein 6
Gem-associated protein 7
Protein phosphatase
Gem-associated protein 4
Gem-associated protein 5
Cellular apoptosis susceptibility protein
NF-kappa-B-activating protein
Prickle (protein)
60S ribosomal protein L5
Twist-related protein 1
Transmembrane protein 53
Retinoblastoma protein
List of MeSH codes (D12.776.660)
UCKL1
Avid Radiopharmaceuticals
RFX6
Gammapapillomavirus
NFIX
PANO1
Proto-oncogene tyrosine-protein kinase Src
MODY 1
MAPK8IP3
Coronavirus nucleocapsid protein
DDX46
Caspase-activated DNase
NOL3
Death-associated protein 6
Papillary carcinomas of the breast
TENM3
Papillary tumors of the pineal region
Paul M. Doty
Genomic imprinting
Genome size
PIR (gene)
SFRS6
HSPA1B
Fragmentation (cell biology)
Sparassis
List of pastoral visits of Pope Francis
Interferon
NOL1
UCL Medical School
OXA1L
Adhesion protein that regulates gene transcription via direct signalling across the nuclear envelope | The University of...
COMPARATIVE PROTEOMICS STUDIES OF SOLUBLE NUCLEAR PROTEINS OF DRUG SUSCEPTIBLE AND RESISTANT HUMAN BREAST CANCER MCF-7 CELLS
OPUS Würzburg | Nup180, a novel nuclear pore complex protein localizing to the cytoplasmic ring and associated fibrils
Arginine Methylation of the Nuclear Poly(A) Binding Protein Weakens the Interaction with Its Nuclear Import Receptor,...
Antibodies against High Mobility Group Box protein-1 (HMGB1) versus other anti-nuclear antibody fine-specificities and disease...
Nuclear Protein Database (NPD)
Human Small Nuclear Ribonucleoprotein Sm D1 protein | Biorbyt
Nuclear Nutrition Isotope Whey Protein Isolate 2 kg
Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation. | J Proteome Res;16(9):...
Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus
Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins
Nuclear Nutrition Hydro High Protein Shot 120 ml - nuclearnutrition.eu
Identification of β-catenin-interacting proteins in nuclear fractions of native rat collecting duct cells<...
We previously reported (K. is normally a virus-encoded nuclear proteins that - Selective and cell-active inhibitors of PI3K
Efficient plant male fertility depends on vegetative nuclear movement mediated by two families of plant outer nuclear membrane...
Mouse NFE2L2(Nuclear Factor, Erythroid Derived 2 Like Protein 2) ELISA Kit - Mid-Atlantic Region ACPE, Inc.
RCSB PDB - 2J1Z: Human p53 core domain mutant M133L-V203A-N239Y-N268D-F270L
Computational analysis of pathological images enables a better diagnosis of TFE3 Xp11.2 translocation renal cell carcinoma |...
Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase...
RNA-binding protein TLS is a major nuclear aggregate-interacting protein in Huntingtin exon 1 with expanded polyglutamine...
Identification and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR)...
Cells | Free Full-Text | Mitotic Chromosomes in Live Cells Characterized Using High-Speed and Label-Free Optical Diffraction...
SP110 gene: MedlinePlus Genetics
Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis
Horseshoe Crab Research Database
Advanced Search Results - Public Health Image Library(PHIL)
NIOSHTIC-2 Search Results - Full View
Publications by CBC Staff | AMNH
Membrane9
- Edinburgh-led study identifies a novel function for the cell adhesion protein Mena at the nuclear membrane, where it regulates actin-nuclear lamina associations, nuclear architecture, chromatin repositioning and gene expression. (ed.ac.uk)
- Colocalisation of Mena with nesprin-2 (left) and model of the proposed role for Mena at the nuclear membrane (right) [for details see Nat. (ed.ac.uk)
- Cell adhesion complexes - protein complexes that form with adhesion receptors in the cell membrane and mediate interactions between neighbouring cells or with molecules in the surrounding extracellular environment - and the cytoskeleton, a structure that helps cells maintain their shape and internal organisation, have well established functions as sensors of mechanical forces and key mediators of mechanotransduction. (ed.ac.uk)
- They employed cutting-edge technologies, including quantitative proteomics, high- and super-resolution cell imaging and DNA sequencing, to show that a protein called Mena, which is usually found at sites of cell adhesion near the plasma membrane, has a role in transmitting force from the cytoskeleton into the nucleus of cells. (ed.ac.uk)
- Due to the substantial progress in elucidation of the structure of the nuclear membrane and pore complex, recently novel autoantigens localised within the nucleus and the nuclear envelope have been investigated in more detail. (openrheumatologyjournal.com)
- 2 ] differentiate the nuclear envelope (NE) into five regions, the outer nuclear membrane (ONM), an inter membrane space, the inner nuclear membrane (INM), the underlying nuclear lamina and the nuclear pore complex (NPC). (openrheumatologyjournal.com)
- In X-linked EDMD, immunohistochemical staining using an antiemerin antibody shows the absence of normal staining of the inner nuclear membrane in 95% of patients (see image below). (medscape.com)
- Multiple and surprising new functions for emerin, a nuclear membrane protein. (medscape.com)
- Efficient plant male fertility depends on vegetative nuclear movement mediated by two families of plant outer nuclear membrane proteins. (pollennetwork.org)
Nucleocytoplasmic transport4
- Given the role of nuclear pore complex proteins in general nucleocytoplasmic transport, our study revealed a novel role of Nup210 in promoting metastasis. (nih.gov)
- This suggests that the C9ORF72 mutation may cause disease by disrupting this process, called nuclear or nucleocytoplasmic transport. (nih.gov)
- The screen identified numerous genes that encode components of the nuclear pore and the nucleocytoplasmic transport machinery, providing strong evidence for this pathway as the mechanism of neurodegeneration. (nih.gov)
- NTF2 is a cytosolic proteins responsible for nuclear import of Ran a small Ras-like GTPase involved in a number of critical cellular processes including cell cycle regulation chromatin corporation during mitosis reformation of the nuclear envelope following mitosis and controlling the directionality of nucleocytoplasmic transport. (tech-strategy.org)
Transcriptional4
- In the renal collecting duct, vasopressin stimulates the nuclear translocation and phosphorylation (at Ser 552 ) of β-catenin, a multifunctional protein that acts as a transcriptional coregulator in the nucleus. (johnshopkins.edu)
- The purpose of this study was to identify β-catenin-interacting proteins that might be involved in transcriptional regulation in rat inner medullary collecting duct (IMCD) cells, using experimental and computational approaches. (johnshopkins.edu)
- In the renal collecting duct, vasopressin stimulates the nuclear translocation and phosphorylation (at Ser552) of β-catenin, a multifunctional protein that acts as a transcriptional coregulator in the nucleus. (johnshopkins.edu)
- We previously reported (K. is normally a virus-encoded nuclear proteins that functions being a transcriptional transactivator from the individual immunodeficiency pathogen type CB7630 1 (HIV-1) CB7630 longer terminal do it again (LTR). (researchtoactionforum.org)
Cytoplasmic4
- Rabbit anti-HMGB1 antibodies gave rise to cytoplasmic, but not nuclear, staining of HEp-2 cells. (biomedcentral.com)
- Comprehensive Identification of Nuclear and Cytoplasmic TNRC6A-Associating Proteins. (nih.gov)
- Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which is classically characterised by a variety of autoantibodies to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), other nuclear and cytoplasmic antigens. (openrheumatologyjournal.com)
- In both vegetative and reproductive organs, FIE formed cytoplasmic high-molecular-mass complexes, in parallel to the nuclear PRC2 complexes. (tau.ac.il)
Pore complex protein1
- This screen identified nuclear pore complex protein, Nup210 as a potential metastatic susceptibility gene. (nih.gov)
Mutations8
- The most common mutations change single protein building blocks (amino acids) in the ATRX protein. (medlineplus.gov)
- Other mutations insert or delete genetic material in the ATRX gene or alter how the gene's instructions are used to make the protein. (medlineplus.gov)
- Mutations may destabilize the ATRX protein or affect its interactions with other proteins. (medlineplus.gov)
- Argentaro A, Yang JC, Chapman L, Kowalczyk MS, Gibbons RJ, Higgs DR, Neuhaus D, Rhodes D. Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX. (medlineplus.gov)
- Four and a half LIM protein 1 gene mutations cause four distinct human myopathies: a comprehensive review of the clinical, histological and pathological features. (medscape.com)
- 2002). These disorders and their relationship to LMNA mutations have been reviewed recently {Burke and Stewart (2002)}, and Hutchinson (2002) has reviewed the function of lamins in the nuclear envelope. (nih.gov)
- RESEARCH OBJECTIVES Lamin A is a major component of the nuclear envelope, so mutations in this gene are likely to have a broad impact on both nuclear structure and function. (nih.gov)
- Examples of research topics appropriate for this Program Announcement include, but are not limited to, proposals to: o Characterize changes in nuclear structure and/or post-translational processing of nuclear envelope proteins caused by mutations in the LMNA gene. (nih.gov)
Macromolecules1
- Nucleocytoplasmic trafficking of macromolecules can be controlled by protein that have the capability to move openly through the pore from the NPC. (tech-strategy.org)
Nucleus6
- For quite a while, researchers have known that mechanical forces are important for regulation of multiple cellular processes, including genome organisation and gene expression in the cell nucleus, but the mechanisms involved and the links between cell adhesion complexes, cytoskeletal proteins and nuclear functions remain poorly understood. (ed.ac.uk)
- They discovered that Mena interacts with the nuclear envelope protein nesprin-2 and that it regulates the morphology of the nucleus, the organisation of chromatin and gene expression. (ed.ac.uk)
- The non-histone nuclear protein high mobility group box protein-1 (HMGB1) is typically associated with nucleosomes, but may shuttle between the nucleus and the cytoplasm, and under some conditions also be released extracellularly and participate in systemic inflammation. (biomedcentral.com)
- RanGAP is important for transporting material between the cell's gel-like interior (cytoplasm) and the nucleus though a structure called the nuclear pore. (nih.gov)
- Protein that are destined towards the nucleus have a very nuclear localization sign (NLS) and protein targeted for the cytoplasm include a nuclear export sign (NES). (tech-strategy.org)
- Proteins export happens by an identical mechanism needing the recognition from the NES including cargo from the exportin such as GSK256066 2,2,2-trifluoroacetic acid for example Crm1 in the nucleus. (tech-strategy.org)
Lamin2
- Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy. (medscape.com)
- 2002. Homozygous defects in LMNA, encoding lamin A/C nuclear envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse. (nih.gov)
Complexes4
- Thus, antibodies against double-stranded (ds) DNA, histones and DNA-histone complexes typically produce a homogeneous nuclear staining pattern on non-dividing cells, and staining of the condensed chromatin-associated antigens in mitotic cells. (biomedcentral.com)
- This attribute is useful for assigning protein-ligand complexes when the assignments of the unliganded protein are known. (cmu.edu)
- PcGs form nuclear multi-subunit Polycomb Repressive Complexes (PRCs). (tau.ac.il)
- The nuclear envelope can be perforated with huge proteinaceous assemblies referred to as nuclear pore complexes (NPCs). (tech-strategy.org)
Envelope4
- Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity. (medscape.com)
- o Characterize age-related changes in lamins and the nuclear envelope, and determine whether these play any role in development of adverse phenotypes during normal aging. (nih.gov)
- 2002. Life at the edge: The nuclear envelope and human disease. (nih.gov)
- This segregation needs that exchange of substances between your two compartments occurs over the dual lipid bilayer from the nuclear envelope for both procedures to operate optimally. (tech-strategy.org)
Autoantibodies1
- Recently several novel autoantibodies against a variety of specific nuclear pore proteins have been described, including the nucleoporin p62. (openrheumatologyjournal.com)
Binds1
- It really is a 95- to 105-kDa proteins that binds DNA through C-terminal zinc finger motifs (59, 60). (researchtoactionforum.org)
Genes5
- Although the specific function of the ATRX protein is unknown, studies suggest that it helps regulate the activity (expression) of other genes through a process known as chromatin remodeling. (medlineplus.gov)
- The ATRX protein appears to regulate the expression of two genes, HBA1 and HBA2 , that are necessary for the production of hemoglobin. (medlineplus.gov)
- Other genes regulated by the ATRX protein have not been identified. (medlineplus.gov)
- Researchers believe that the RAD21 protein, as a structural component of the cohesin complex, also plays important roles in stabilizing cells' genetic information, repairing damaged DNA, and regulating the activity of certain genes that are essential for normal development. (nih.gov)
- A defective or missing RAD21 protein likely alters the activity of the cohesin complex, impairing its ability to regulate genes that are critical for normal development. (nih.gov)
Chromatin6
- This work establishes a connection between the adhesome component Mena and the LINC complex, through which Mena regulates actin-nuclear lamina interactions, nuclear architecture and chromatin organisation at the nuclear periphery, fine-tuning gene expression. (ed.ac.uk)
- Electron microscopy of patients with EMD1 and EMD2 can show irregularly thickened nuclear lamina, rearranged heterochromatin, chromatin condensation and decondensation, focal chromatin loss or extrusion into the sarcoplasm, nuclear disintegration/fragmentation and tubulofilamentous inclusions within the nuclear matrix. (medscape.com)
- Chromatin is the complex of DNA and protein that packages DNA into chromosomes. (medlineplus.gov)
- Polycomb group (PcG) proteins are evolutionarily conserved chromatin modifiers that regulate developmental pathways in plants. (tau.ac.il)
- The cytosolic accumulation of PRC2 components in plants supports the model that PcGs have alternative non-nuclear functions that go beyond chromatin methylation. (tau.ac.il)
- We used a standard chromatin immunoprecipitation procedure coupled to mass spectrometry (ChIP-MS) in a nuclear fraction isolated from rat IMCD suspensions. (johnshopkins.edu)
Fractions1
- Product is produced in the process of multi-stage cross-flow microfiltration which allows the best fractions of proteins to be obtained, while also retaining their biological properties. (fasklep.pl)
Localization3
- Recently, nuclear localization of tTG has been reported indicating the potential of active nuclear transport. (nih.gov)
- Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein. (nih.gov)
- Proteins 49 to 58 comprise a basic-charged area essential for nuclear localization and binding towards the HIV head RNA, TAR (14, 23, 41, 93). (researchtoactionforum.org)
Whey protein4
- FA WELLNESS WHEY PROTEIN protein supplement is a product in the form of an easily dissolvable powder, which allows you to enrich your daily diet with high-quality whey protein. (fasklep.pl)
- The nutrient uses one of the most popular forms of whey protein, which is whey protein concentrate (WPC). (fasklep.pl)
- Protein product that provides the purest whey protein isolate. (fasklep.pl)
- Nuclear Nutrition Atomic Whey Protein. (nuclearnutrition.eu)
Interactions1
- o Determine how changes in the nuclear interactions of the lamins contribute to cardiovascular disease. (nih.gov)
Regulate1
- o Determine the cell-specific functions of the lamins in cells of the cardiovascular system, such as endothelial cells and cardiac and vascular smooth muscle cells, and the molecular mechanisms through which these proteins control and regulate cellular function. (nih.gov)
Interacts2
Nucleoporins1
- The proteins components composed of the NPC participate in several proteins known as nucleoporins (Nups). (tech-strategy.org)
Different nuclear2
- Depending on the many different nuclear target antigens for ANA, different IF-staining patterns can be seen. (biomedcentral.com)
- The nuclear pore complex (NPC) serves as the sole gate between the nucleoplasm and the cytoplasm and contains several different nuclear pore proteins such as nucleoporin p62. (openrheumatologyjournal.com)
Abnormal1
- Taken together, these studies don't prove whether abnormal RNA-protein binding, toxic protein products, or both are responsible for diseases caused by these G 4 C 2 repeats. (nih.gov)
Identification1
- Protein identification is acquired by peptide fingerprinting or microsequencing. (umd.edu)
Nuclei3
- Since most anticancer drugs target the nuclei of the cancer cells, differential expression of nuclear proteins may play crucial roles as cancer cells acquire drug resistance. (umd.edu)
- Neurons (red), created from ALS patients bearing the C9ORF72 expansion, show clumps of the RanGAP protein (yellow) on their nuclei (white). (nih.gov)
- Analysing endogenous FIE and transgenic gFIE-green fluorescent protein fusion protein (gFIE-GFP) showed that FIE accumulates in the nuclei of every cell type examined. (tau.ac.il)
Complex1
- The RAD21 protein is part of a protein group called the cohesin complex that holds the sister chromatids together. (nih.gov)
Phosphorylation1
- Moreover increased phosphorylation of a phospho-tyrosine protein and several phospho-threonine proteins was observed in polysorbitan monolaurate treated cells. (tech-strategy.org)
Roles2
- Some of the proteins whose abundances are altered have also been reported to play important roles in resisting genotoxic stress in other normal and cancer cells. (umd.edu)
- Since TIF-1 proteins have significant roles in oncogenesis, these antibodies may be produced during misdirected antitumor immunity. (nih.gov)
Cells8
- Thus I have carried out a comparative proteomics research project to study differential expression of nuclear proteins in drug resistant human breast cancer MCF-7 cells. (umd.edu)
- One hundred and twenty proteins have been identified from the nuclear protein mixture of MCF-7 cells, from which more than 90% are classically categorized as nuclear proteins. (umd.edu)
- In contrast, ANA specific for extrachromosomal antigens can be identified as a speckled nuclear staining pattern in non-dividing cells, and diffuse extra-chromosomal staining of dividing cells. (biomedcentral.com)
- Hemoglobin is the protein in red blood cells that carries oxygen to cells throughout the body. (medlineplus.gov)
- The overly long RNA might alter the function of RNA-binding proteins or cause cells to produce toxic proteins. (nih.gov)
- of Ran and the nuclear export processes are restored in polysorbitan monolaurate treated cells overproducing NTF2. (tech-strategy.org)
- In these cases, the entire gene is missing from one copy of the chromosome in each cell, so cells produce a reduced amount of RAD21 protein. (nih.gov)
- As a result of this deletion, affected individuals are missing one copy of the RAD21 gene in each cell, so cells produce a reduced amount of RAD21 protein. (nih.gov)
Alters1
- Researchers from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia. (nih.gov)
Tissue6
- Interaction of tissue transglutaminase with nuclear transport protein importin-alpha3. (nih.gov)
- Alteration of mismatch repair system protein expression detected by immunohistochemistry (IHQ) in tumoural tissue is a useful technique for Lynch Syndrome (LS) screening . (bvsalud.org)
- He studies the role of tissue-specific RNA binding proteins in the function and development of tissue. (nih.gov)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids. (maracpe.org)
- Description: A sandwich quantitative ELISA assay kit for detection of Rat Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) in samples from tissue homogenates, cell lysates or other biological fluids. (maracpe.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) in tissue homogenates, cell lysates and other biological fluids. (maracpe.org)
Function2
Factor2
- This decrease was coincidental with a significant reduction of the nuclear factor (NF)-κB activity. (nih.gov)
- Description: A sandwich ELISA kit for detection of Nuclear Factor, Erythroid Derived 2 Like Protein 2 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (maracpe.org)
Amino1
- Nuclear Nutrition Impact Complete Amino. (nuclearnutrition.eu)
Recognition1
- Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins. (nih.gov)
Physically active people1
- FA NUTRITION BILLIONAIRE PROTEIN BAR is an excellent choice for physically active people who care about a varied diet. (fasklep.pl)
Yeast1
- Experiments in yeast demonstrated toxic protein effects. (nih.gov)
Gene expression1
- These changes prevent the ATRX protein from effectively regulating gene expression. (medlineplus.gov)
Study3
- Prevalence of altered mismatch repair protein nuclear expression detected by immunohistochemistry on adenomas with high-grade dysplasia and features associated with this risk in a population-based study]. (bvsalud.org)
- A third study, published in Nature Neuroscience by a team led by Stanford University's Dr. Aaron Gitler, focused on the potential toxic effects of proteins produced by the expanded G 4 C 2 repeats. (nih.gov)
- Thus, this study not only reveals an important nuclear migration mechanism in plant fertilization but also, suggests that similar nuclear migration machinery is conserved between plants and animals. (pollennetwork.org)
Migration5
- Increasing evidence suggests that nuclear migration is important for eukaryotic development. (pollennetwork.org)
- Although nuclear migration is conserved in plants, its importance for plant development has not yet been established. (pollennetwork.org)
- The most extraordinary plant nuclear migration events involve plant fertilization, which is starkly different from that of animals. (pollennetwork.org)
- Here, we report that WPP domain-interacting proteins (WIPs) and their binding partners the WPP domain-interacting tail-anchored proteins (WITs) are essential for pollen nuclear migration. (pollennetwork.org)
- KASH proteins are key players in animal nuclear migration. (pollennetwork.org)
Transport2
Similar1
- MCF-7 cell lines resistant to etoposide and mitoxantrone are more similar in protein abundance changes. (umd.edu)
Expression2
- Using electron microscopy we demonstrate that nuclear expression of tTG in a non-small cell lung cancer cell line is induced by retinoic acid (RA). (nih.gov)
- The percentage of pathologic nuclear expression found in IHQ is high. (bvsalud.org)
Mechanism1
- A shortage of RAD21 protein may contribute to intellectual disability, but the mechanism is unclear. (nih.gov)