Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.
Synthetic analogs of NUCLEIC ACIDS composed of morpholine ring derivatives (MORPHOLINES) linked by phosphorodimidates. One standard DNA nucleic acid base (ADENINE; GUANINE; CYTOSINE; OR THYMINE) is bound to each morpholine ring.
The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.
Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.
Membranous appendage of fish and other aquatic organisms used for locomotion or balance.
Aquatic vertebrate sensory system in fish and amphibians. It is composed of sense organs (canal organs and pit organs) containing neuromasts (MECHANORECEPTORS) that detect water displacement caused by moving objects.
The posterior of the three primitive cerebral vesicles of an embryonic brain. It consists of myelencephalon, metencephalon, and isthmus rhombencephali from which develop the major BRAIN STEM components, such as MEDULLA OBLONGATA from the myelencephalon, CEREBELLUM and PONS from the metencephalon, with the expanded cavity forming the FOURTH VENTRICLE.
Paired, segmented masses of MESENCHYME located on either side of the developing spinal cord (neural tube). Somites derive from PARAXIAL MESODERM and continue to increase in number during ORGANOGENESIS. Somites give rise to SKELETON (sclerotome); MUSCLES (myotome); and DERMIS (dermatome).
Morphological and physiological development of EMBRYOS.
The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE-STRANDED RNA, such as SMALL INTERFERING RNA and RNA containing HAIRPIN LOOP SEQUENCE, and ANTI-SENSE OLIGONUCLEOTIDES.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.
Short fragments of DNA or RNA that are used to alter the function of target RNAs or DNAs to which they hybridize.
Members of the transforming growth factor superfamily that play a role in pattern formation and differentiation during the pregastrulation and GASTRULATION stages of chordate development. Several nodal signaling ligands are specifically involved in the genesis of left-right asymmetry during development. The protein group is named after a critical region of the vertebrate embryo PRIMITIVE STREAK referred to as HENSEN'S NODE.
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
A process of complicated morphogenetic cell movements that reorganizes a bilayer embryo into one with three GERM LAYERS and specific orientation (dorsal/ventral; anterior/posterior). Gastrulation describes the germ layer development of a non-mammalian BLASTULA or that of a mammalian BLASTOCYST.
A cartilaginous rod of mesodermal cells at the dorsal midline of all CHORDATE embryos. In lower vertebrates, notochord is the backbone of support. In the higher vertebrates, notochord is a transient structure, and segments of the vertebral column will develop around it. Notochord is also a source of midline signals that pattern surrounding tissues including the NEURAL TUBE development.
The relationships of groups of organisms as reflected by their genetic makeup.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A region, of SOMITE development period, that contains a number of paired arches, each with a mesodermal core lined by ectoderm and endoderm on the two sides. In lower aquatic vertebrates, branchial arches develop into GILLS. In higher vertebrates, the arches forms outpouchings and develop into structures of the head and neck. Separating the arches are the branchial clefts or grooves.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Formation of differentiated cells and complicated tissue organization to provide specialized functions.
An early non-mammalian embryo that follows the MORULA stage. A blastula resembles a hollow ball with the layer of cells surrounding a fluid-filled cavity (blastocele). The layer of cells is called BLASTODERM.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
The middle germ layer of an embryo derived from three paired mesenchymal aggregates along the neural tube.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Chromatophores (large pigment cells of fish, amphibia, reptiles and many invertebrates) which contain melanin. Short term color changes are brought about by an active redistribution of the melanophores pigment containing organelles (MELANOSOMES). Mammals do not have melanophores; however they have retained smaller pigment cells known as MELANOCYTES.
A family of intercellular signaling proteins that play and important role in regulating the development of many TISSUES and organs. Their name derives from the observation of a hedgehog-like appearance in DROSOPHILA embryos with genetic mutations that block their action.
A genus of pufferfish commonly used for research.
The paired caudal parts of the PROSENCEPHALON from which the THALAMUS; HYPOTHALAMUS; EPITHALAMUS; and SUBTHALAMUS are derived.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The primordial kidney that develops from the INTERMEDIATE MESODERM in the embryos of vertebrates, and is succeeded by the MESONEPHROS. In higher vertebrates and humans, the pronephros is a vestigial and transient structure.
The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.
The physiological renewal, repair, or replacement of tissue.
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
The only genus in the family Oryziinae, order BELONIFORMES. Oryzias are egg-layers; other fish of the same order are livebearers. Oryzias are used extensively in testing carcinogens.
A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. Many SOX transcription factors play important roles in regulating CELL DIFFERENTIATION. The numerous members of this family are organized in several subgroups according to structural identities found within the proteins.
An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes.
The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
Thin-walled sacs or spaces which function as a part of the respiratory system in birds, fishes, insects, and mammals.
Short fragments of DNA that are used to alter the function of target RNAs or DNAs to which they hybridize.
Used in the form of its salts as a dye and as an intermediate in manufacture of Acid Yellow, diazo dyes, and indulines.
In zebrafish[edit]. Zebrafish, like other teleost fish, possess the innate ability to regenerate retinal damage. This ability ... Retinal regeneration in zebrafish is mediated by Muller glia, which dedifferentiate into stem-like cells and proliferate into ... Rod precursors are produced during normal zebrafish growth and localize to the outer nuclear layer of the retina. In the event ... "β-catenin/Wnt signaling controls progenitor fate in the developing and regenerating zebrafish retina". Neural Development. 2012 ...
Ekker SC (2008). "Zinc finger-based knockout punches for zebrafish genes". Zebrafish. 5 (2): 121-3. doi:10.1089/zeb.2008.9988. ...
Ekker SC (2008). "Zinc finger-based knockout punches for zebrafish genes". Zebrafish. 5 (2): 121-3. doi:10.1089/zeb.2008.9988. ...
Genus information: Kallman, Klaus D.; Kazianis, Steven (2006). "The GenusXiphophorusin Mexico and Central America". Zebrafish. ...
Ekker SC (2008). "Zinc Finger-Based Knockout Punches for Zebrafish Genes". Zebrafish. 5 (2): 1121-1123. doi:10.1089/zeb. ... Similar research of using ZFNs to create specific mutations in zebrafish embryo has also been carried out by other research ... The kdr gene in zebra fish encodes for the vascular endothelial growth factor-2 receptor. Mutagenic lesions at this target site ... Meng X, Noyes MB, Zhu LJ, Lawson ND, Wolfe SA (June 2008). "Targeted gene inactivation in zebrafish using engineered zinc ...
Zebrafish. 2 (4): 243-257. CiteSeerX 10.1.1.210.7203. doi:10.1089/zeb.2005.2.243. PMID 18248183. Koentges, G; Matsuoka, T (2002 ...
Kallman, K.D.; S. Kazianis (2006). "The genus Xiphophorus in Mexico and Central America". Zebrafish. 3 (3): 271-285. doi: ...
Grush J, Noakes DL, Moccia RD (February 2004). "The efficacy of clove oil as an anesthetic for the zebrafish, Danio rerio ( ... Hamilton)". Zebrafish. 1 (1): 46-53. doi:10.1089/154585404774101671. PMID 18248205. Monks, Neale (2 April 2009). "Aquarium Fish ...
S.C. Ekker (2008). "Zinc finger-based knockout punches for zebrafish genes". Zebrafish. 5 (2): 1121-3. doi:10.1089/zeb. ... zebrafish, various types of mammalian cells, and rats. An ongoing clinical trial is evaluating Zinc finger nucleases that ...
Page L, Polok B, Bustamante M, Schorderet DF (2013). "Bigh3 is upregulated in regenerating zebrafish fin". Zebrafish. 10 (3): ...
Price, Anna; Weadick, Cameron; Shim, Janet; Rodd, Frieda (2009-01-01). "Pigments, Patterns, and Fish Behavior". Zebrafish. 5 (4 ...
"KSI - Domain". Zebrafish. 25 December 2020. Retrieved 5 December 2020. "KSI - Domain". 25 December 2020. Retrieved 25 December ...
Her lab uses zebrafish as a genetic model to research retinal stem cells. From 1997 to 2002, Raymond was the associate provost ... Zebrafish. 2 (3): 157-164. 2005. doi:10.1089/zeb.2005.2.157. ISSN 1545-8547. "Raymond Lab , Molecular, Cellular, and ...
March 2013). "A sequence-based variation map of zebrafish". Zebrafish. 10 (1): 15-20. doi:10.1089/zeb.2012.0848. PMC 3629779. ... "Genome of Zebrafish Wild-type Strain (ASWT)". IGIB.in. Retrieved 17 April 2013. "Detailed map of TB genome to help treatment". ... analysis of the first Malaysian Genome sequencing and analysis of the Wild-type strain of Zebrafish and the IndiGen programme ... colleagues at the Institute of Genomics and Integrative Biology announced the sequencing of the wild-type strain of zebrafish ...
Bill BR, Petzold AM, Clark KJ, Schimmenti LA, Ekker SC (March 2009). "A primer for morpholino use in zebrafish". Zebrafish. 6 ( ... Flynt AS, Li N, Thatcher EJ, Solnica-Krezel L, Patton JG (February 2007). "Zebrafish miR-214 modulates Hedgehog signaling to ... Draper BW, Morcos PA, Kimmel CB (July 2001). "Inhibition of zebrafish fgf8 pre-mRNA splicing with morpholino oligos: a ... These molecules have been applied to studies in several model organisms, including mice, zebrafish, frogs and sea urchins. ...
... "mc1r Pathway regulation of zebrafish melanosome dispersion". Zebrafish. 5 (4): 289-95. doi:10.1089/zeb.2008.0541. PMID 19133827 ... For example, zebrafish larvae are used to study how chromatophores organise and communicate to accurately generate the regular ... It is known in zebrafish embryos, for example, that by 3 days after fertilization each of the cell classes found in the adult ... It has been demonstrated that MC1R is required in zebrafish for dispersion of melanin. Inside the cell, cyclic adenosine ...
Clark KJ, Voytas DF, Ekker SC (September 2011). "A TALE of two nucleases: gene targeting for the masses?". Zebrafish. 8 (3): ...
Zebrafish given access to a barren, brightly lit chamber or an enriched chamber prefer the enriched area. When these fish are ... In contrast, zebrafish (Danio rerio) reduce their frequency of swimming and increase their ventilation rate but do not display ... Five-day old zebrafish larvae show a concentration dependent increase in locomotor activity in response to different ... When the same noxious stimulus is applied to zebrafish (Danio rerio), they respond by decreasing their activity. As with the ...
Fleisch, VC; Neuhauss, SCF (2006). "Visual Behavior in Zebrafish". Zebrafish. 3 (2): 191-201. doi:10.1089/zeb.2006.3.191. PMID ... In zebrafish, the optomotor response is frequently used as a metric of visual performance as it can be reliably evoked from 7 ... For instance, when zebrafish larvae are presented with a sinusoidal black and white grating pattern, the larvae will turn and ... Schmitt, EA; Dowling, JE (1994). "Early eye morphogenesis in the zebrafish, Brachydanio rerio". J Comp Neurol. 344 (4): 532-42 ...
Zebrafish and prairie voles have also become more common, especially in the social and behavioral scopes of neurogenetics. In ... Oliveira RF, Silva JF, Simões JM (June 2011). "Fighting zebrafish: characterization of aggressive behavior and winner-loser ... Burgess HA, Granato M (November 2008). "The neurogenetic frontier--lessons from misbehaving zebrafish". Briefings in Functional ... and zebrafish, to try to determine specific genes that correlate to behavior and attempt to match these with human genes. While ...
The Zebrafish Genome, which is being fully sequenced and manually annotated. The Zebrafish genome currently has 18,454 ... "Havana Project". Sprague, J. (1 January 2006). "The Zebrafish Information Network: the zebrafish model organism database". ... VEGA homepage Jen Harrow Bio WTSI homepage ENCODE homepage ZFIN Homepage Zebrafish Wild Type Strain Genome Zebrafish Genome ... It was designed to view manual annotations of human, mouse and zebrafish genomic sequences, and it is the central cache for ...
"Zebrafish SHHa". University of Oregon. Archived from the original on 2009-06-25. "Zebrafish SHHb". University of Oregon. ... In the zebrafish, two of the three vertebrate hh genes are duplicated: SHH a and SHH b (formerly described as tiggywinkle ... Currie PD, Ingham PW (August 1996). "Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish". Nature ... Lewis KE, Eisen JS (September 2001). "Hedgehog signaling is required for primary motoneuron induction in zebrafish". ...
JME - Pull Up". Zebrafish Media. 4 May 2019. Archived from the original on 11 July 2020. Retrieved 4 May 2019. "KSI & Randolph ...
Zebrafish Information Network. Retrieved 10 November 2017. CS1 maint: discouraged parameter (link) Westerfield, Monte; Doerry, ... and led the technology team that conceived of and built the Zebrafish Information Network, an international online multimedia ... Eckehard; Kirkpatrick, Arthur E.; Driever, Wolfgang; Douglas, Sarah Ann (1997). "An on-line database for zebrafish development ... database of information for zebrafish researchers. She is the author of over 70 technical papers and a research monograph, The ...
"Breeding Zebrafish" (Chapter 2). The Zebrafish Book. Retrieved 2006-05-02. CS1 maint: discouraged parameter (link) "Substrate ...
In zebrafish, Nkd genes regulate Wnt signaling. The mRNA transcription of Nkd genes is inducible by Wnt signaling in diverse ... Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Dev Biol. 2010 Dec 1;348(1):22-33. Epub 2010 ... Epub 2007 Apr 16.PMID 17438140 Van Raay TJ, Coffey RJ, Solnica-Krezel L. Zebrafish Naked1 and Naked2 antagonize both canonical ... Nkd3 in zebrafish). Mice with a mutant Nkd1 protein had a mild sperm maturation defect, but mice lacking both Nkd1 and Nkd2 ...
... is on the executive board of the European Zebrafish Society EZB e.V. and on the advisory board of the ... "Board". European Zebrafish Society. "Our Advisory Board". International Society for Regenerative Biology. "MRC Suffrage in ... The Becker group established the zebrafish as a model for spinal cord regeneration. Their research found that functional ... "Lesion-induced generation of interneuron cell types in specific dorsoventral domains in the spinal cord of adult zebrafish". ...
... , also known as zebrafish or stripey bream, is a species of marine ray-finned fish, a sea chub in the family ... Bray, D.J.; Gomon, M.F. (2011). "Zebrafish, Girella zebra". Taxonomic Toolkit for marine life of Port Phillip Bay. Museum ... Bray, D.J. (2018). "Girella zebra". Fishes of Australia. Museums Victoria. Retrieved 25 April 2020. Mark McGrouther (19 March ... Bray, D.; Gomon, M. (2018). "Girella zebra Zebrafish in Museums Victoria Collections". Museums Victoria. Retrieved 25 April ...
2006). "ZFIN Pharyngula Period Description". Zebrafish Information Network. Retrieved 2007-07-18. Haeckel E (1874) ...
Zebrafish: Danio rerio. Good embryo supply. Well developed genetics. Chicken: Gallus gallus. Early stages similar to mammal, ... "Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish". Developmental Cell. 21 (1 ...
The Zebrafish Information Network (ZFIN) is an online biological database of information about the zebrafish (Danio rerio). The ... Vega Zebrafish Genome Annotation. *FishMap : The Zebrafish Community Genomics Browser maintained at the Institute of Genomics ... Sprague et al. (2008). The Zebrafish Information Network: the zebrafish model organism database provides expanded support for ... the China Zebrafish Resource Center (CZRC), and so on, which maintain and provide zebrafish-related research resources, ...
Enter the zebrafish larva. Small and transparent-yet able to swim freely and even hunt small prey-these baby fish have long ... Zebrafish Study Reveals First Fine Structure of a Complete Vertebrate Brain.. Despite decades of stunning advances in imaging ... Zebrafish larva head in cross-section. Note this isnt a single electron microscope image, but many thousands of slices seen on ... "What makes the zebrafish such a spectacular system is that the alternatives in other organisms for deriving wiring diagrams are ...
The first step of pronephrogenesis in the zebrafish is the formation of the intermediate mesoderm during gastrulation, which... ... Drummond IA (2005) Kidney development and disease in the zebrafish. J Am Soc Nephrol 16:299-304PubMedCrossRefGoogle Scholar ... Hu N, Yost HJ, Clark EB (2001) Cardiac morphology and blood pressure in the adult zebrafish. Anat Rec 264:1-12PubMedCrossRef ... Drummond IA, Davidson AJ (2010) Zebrafish kidney development. Methods Cell Biol 100:233-260PubMedCrossRefGoogle Scholar ...
A zebrafish can even regrow parts of its heart.. ...glow-in-the-dark. Through genetic modification you can make zebrafish glow ... Zebrafish. Zebrafish larvae have evolved into a very attractive model for drug discovery. Recently published methods facilitate ... Zebrafish embryos grow their organs the same way as humans, only 20 times faster and one zebrafish pair generates about 200 ... Roche is at the head of the class when it comes to the school of zebrafish research, and is pursuing the use of zebrafish in ...
Image 2 (below): Zebrafish with certain genes turned off during embryonic development (center and right images) showed ... As such, Sive and other researchers began looking at zebrafish genes that were analogous to the human genes found in region ... "This is really nice work that shows the importance of zebrafish in revealing disease mechanisms related to human mental ... the MIT study showed that almost all of them led to brain abnormalities when eliminated from zebrafish embryos. The results of ...
... zebrafish) tRNA (guanine(46)-N(7))-methyltransferase (zebrafish) methyltransferase-like protein 1 (zebrafish) ... A tRNA (guanine-N(7)-)-methyltransferase that is encoded in the genome of zebrafish. [ PRO. :. DNx OMA. :. Q5XJ57 ] ... Synonyms: z-METTL1 tRNA(m7G46)-methyltransferase (zebrafish) miRNA (guanine-N(7)-)-methyltransferase ( ... tRNA (guanine-N(7)-)-methyltransferase (zebrafish). Go to external page http://purl.obolibrary.org/obo/PR_Q5XJ57 Copy ...
Zebrafish and Skin Color. This is a part of The Biology of Skin Color ... This lesson complements the film The Biology of Skin Color and explores how experimental work in zebrafish led to a better ...
Rodents and zebrafish against cancer. With the help of animal models, scientists have extended the lives of pancreatic cancer ... In another study led by Zon, the team examined effects of various chemical compounds on pigments in zebrafish (and frogs too). ... Zebrafish can develop a form of the disease genetically similar to human skin cancer tumors. ... Genetically engineered mice and zebrafish enabled new research towards treatments for pancreatic and skin cancers, respectively ...
Genetically engineered zebrafish could provide a quick way to test new drugs to prevent dangerous plaque buildup in the heart. ...
Zebrafish publications at Brown University (in PubMed). JoVE video on the automated analysis of behavior in zebrafish larvae ( ...
Scientists became interested in zebrafish only in the 1960s, today the little fish are one of the most popular organisms in ... Zebrafish are unassuming and undemanding. Almost every child knows that - at least any child that has kept fish in an aquarium ... Scientists only discovered the zebrafish, which is a member of the minnow family, for their own purposes in the late 1960s. In ... As a vertebrate, the zebrafish has many genes that have the same, or similiar, functions in mammals and thus also in humans. ...
The zebrafish, Danio rerio, has emerged as a powerful model system for the study of vertebrate development and disease. This ... Lectures and labs will introduce students to early development of the zebrafish and to methods for manipulating and studying ... It will cover standard and novel technologies geared towards their application in zebrafish. Mornings and afternoons will be ... Please see the 2019 MBL zebrafish course poster for more information and to apply. ...
A sequence-based variation map of zebrafish.. Zebrafish. 2013 Mar;10(1):15-20 [Highlighted on the cover of the journal]. For ... 17th July 2009 , Zebrafish Wild Type Strain Genome was presented at the 6th European Zebrafish Genetics and Development Meeting ... Talk Title: WHOLE-GENOME SEQUENCING OF A WILDTYPE STRAIN OF ZEBRAFISH FOR VARIANT DISCOVERY. View abstract of the talk. 27th ... Wild Zebrafish Genome Scientific Article. Patowary A, Purkanti R, Singh M, Chauhan R,Singh AR, Swarnkar M, Singh N, Pandey V, ...
Zebrafish Resources can be found at the central website of the zebrafish community at ZFIN. For example, here you can search ... The Zebrafish Community meets biannually at the International Conference on Zebrafish Development and Genetics, which usually ... recipes and protocols in the online version of the famous Zebrafish Book or the ZFIN Protocol Wiki or for ... The biannual Asia Oceania Zebrafish Meeting alternates with the International Conference and takes place at changing locations ...
Zebrafish develops cancers spontaneously, after chemical mutagenesis or through genetic manipulations. Furthermore, zebrafish ... Finally, zebrafish embryos are used in molecule screens and contribute to the identification of novel anti-cancer therapeutic ... Although cell culture and mouse models will remain a cornerstone of cancer research, the unique capabilities of the zebrafish ... Xenotransplantation of human cancer cells in embryos or adult zebrafish presents the advantage of following cancer cell ...
Toxicological and pharmacological researchers have seized upon the many benefits of zebrafish, including the short generation ... The abundance of sites with non-reference alleles per T5D zebrafish could imply that within a population, zebrafish are more ... 2016), an individual zebrafish within the T5D population may vary more from the current zebrafish reference genome than ... zebrafish). While more variants have been discovered in the human and mouse genomes, the smaller zebrafish genome is on par ...
Epiboly plays a prominent role in zebrafish gastrulation and studies of zebrafish epiboly have provided insights into basic ... Zebrafish epiboly: mechanics and mechanisms.. Lepage SE1, Bruce AE.. Author information. 1. Department of Cell and Systems ... Here, we review work on the molecular and cellular basis of zebrafish epiboly in order to identify unifying themes and to ...
... techniques for developing and analyzing zebrafish disease models, and methods for neuroscience. Zebrafish: Methods and ... This second edition details new emerging areas of zebrafish research focusing on genetics and genomics, ... Zebrafish: Methods and Protocols, Second Edition guides readers through methods for mutagenesis and genome editing in zebrafish ... Authoritative and practical Zebrafish: Methods and Protocols, Second Edition is a useful complement to the first book for new ...
Figure 1: Zebrafish thrombocyte electron micrographs. (a) Zebrafish thrombocyte. Open canalicular like system is shown by ... Development of Zebrafish Model for Thrombopoiesis. In zebrafish, hematopoiesis has been extensively studied [45, 46]. There are ... S. C. Ekker, "Zinc finger-based knockout punches for zebrafish genes," Zebrafish, vol. 5, no. 2, pp. 121-123, 2008. View at ... 2. Development of Zebrafish Model to Study Thrombocyte Function. Unlike mammalian platelets which are anucleated, zebrafish ...
Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, ... We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and ... Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, ... Talbot, W., Trevarrow, B., Halpern, M. et al. A homeobox gene essential for zebrafish notochord development. Nature 378, 150- ...
The zebra fish is widely used in molecular and developmental genetic engineering studies. Our Zebra Fish are hand-selected for size and health, so you can enjoy them for years to come.
... 15.06.2010. This image may bring to mind a patchwork quilt, or a picture taken from a gallery ... As a zebrafish embryo develops, the cells that will form its lateral line have to become pointed at one end and arrange ... Darren Gilmours group at EMBL captured this snapshot of the beginnings of an organ which plays a central role in how zebrafish ...
Disclosure: Walyou is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to amazon.com ...
... Riki Dayan via zbrafish%40net.bio.net (by rdayan from uvic.ca). Tue Mar 16 17:29:10 EST 2010 * ... Does anyone have any suggestions on where to find these? Ive checked with the Zebrafish International Resource Center but the ... Hi, I am studying visual opsins and pigmentation aggregation/dispersion and am looking for an albino zebrafish. ...
A study of zebrafish has revealed ways to potentially slow or prevent the onset of cancerous tumors, the Huntsman Cancer ... Using zebrafish that share genetics similar to humans, researchers discovered two enzymes that, when combined, could be ... 24 (UPI) -- A study of zebrafish has revealed ways to potentially slow or prevent the onset of cancerous tumors, the Huntsman ...
The zebrafish, a translucent fish often used as a model of human development and disease, offers unique advantages for studying ... A particular advantage of using zebrafish to study cancer biology is the ability to transplant human tumors into the fish using ... Their paper "p53 Isoform à "113p53 in Zebrafish" discusses the potential use of this particular p53 isoform for characterizing ... In the paper entitled "Identification of a Heritable Model of Testicular Germ Cell Tumor in the Zebrafish," authors Joanie ...
Purchase Essential Zebrafish Methods: Genetics and Genomics - 1st Edition. Print Book & E-Book. ISBN 9780123751607, ... Cloning Zebrafish by Nuclear Transfer (Shuo Lin). 15. Spatial and Temporal Expression of the Zebrafish Genome by Large-Scale In ... 3. The Zebrafish Genome (John Postlethwait) 4. Retroviral-Mediated Insertional Mutogenesis in Zebrafish (Adam Amsterdam) 5. ... Transgene Manipulation in Zebrafish by Using Recombinases (Gary W. Stuart). 13. Highly Efficient Zebrafish Transgenesis ...
Tropical zebrafish have helped researchers at the University of Sheffield pave the way for the discovery of new anti- ... They were able to show that a number of these drugs worked in zebrafish, thereby establishing that zebrafish could be used to ... "Zebrafish Play Pivotal Role In Helping Treat Disease." Medical News Today. MediLexicon, Intl., 30 Oct. 2009. Web.. 20 Aug. 2018 ... Tropical zebrafish have helped researchers at the University of Sheffield pave the way for the discovery of new anti- ...
... are shown inside the gut of a larval zebrafish. The gut is visible as a gray background. The image is a compilation of a 3.5- ... The rapid trajectories of Vibrio cholerae bacteria, shown in blue, are shown inside the gut of a larval zebrafish. The gut is ... In zebrafish, the cholera bacterium sets off a surprising flush. University of Oregon ...
zebrafish synonyms, zebrafish pronunciation, zebrafish translation, English dictionary definition of zebrafish. or zebra fish n ... zebrafish or ze·bra·fish·es or zebra fish or zebra fish·es A small freshwater fish of South Asia that has horizontal dark blue ... or zebra fish (zē′brə-fĭsh). n. pl. zebrafish or ze·bra·fish·es or zebra fish or zebra fish·es A small freshwater fish (Danio ... Zebrafish - definition of zebrafish by The Free Dictionary https://www.thefreedictionary.com/zebrafish ...
  • The Zebrafish Information Network ( ZFIN ) is an online biological database of information about the zebrafish ( Danio rerio ). (wikipedia.org)
  • The zebrafish, Danio rerio , has emerged as a powerful model system for the study of vertebrate development and disease. (mbl.edu)
  • Institute of Genomics and Integrative Biology ( http://igib.res.in ), which is a constituent laboratory of the Council of Scientific and Industrial Research ( http://www.csir.res.in ) has completed the whole genome sequencing of a Wildtype Strain of Zebrafish (Danio rerio). (google.com)
  • In this regard, we wondered whether Danio rerio (Zebrafish) previously used as a genetic model to study developmental biology could be used as a genetic model to study hemostasis especially platelet biology [ 1 ]. (hindawi.com)
  • A male (7-8 months old) and a female (15-16 months old) zebrafish (Danio rerio), supplied from an importing company and brought to biotechnology laboratory of Istanbul University Faculty of Fisheries Department of Aquaculture, have been used in the study. (thefreedictionary.com)
  • The zebrafish (Danio rerio) is a freshwater fish belonging to the minnow family (Cyprinidae) of the order Cypriniformes. (wikipedia.org)
  • The zebrafish has often been referred to as "Danio rerio", but more recent molecular studies have suggested that it should belong to the genus Brachydanio, as Brachydanio rerio. (wikipedia.org)
  • Scientifically known as Danio rerio, zebrafish get their name from the horizontal blue stripes that run along the sides of their body. (timesofmalta.com)
  • Tiny fish, big research potential: zebrafish (Danio rerio) share 75 per cent of their genome with humans. (timesofmalta.com)
  • Although zebrafish ( Danio rerio ) behavior has been used to rapidly identify neuroactive compounds, it is not clear what types of behavioral assays would be necessary to identify multitarget compounds such as antipsychotics. (nature.com)
  • Danio rerio commonly known as zebrafish is a tropical fish belonging to the minnow family (Cyprinidae). (uniprot.org)
  • The zebrafish ( Danio rerio ) is a powerful vertebrate model system for studying development, modeling disease, and screening for novel therapeutics. (jove.com)
  • Over 60 years after the initial description of PDE, we report the first animal model for this disease: an aldh7a1-null zebrafish ( Danio rerio ) displaying deficient lysine metabolism and spontaneous and recurrent seizures in the larval stage (10 days postfertilization). (genetics.org)
  • The zebrafish ( Danio rerio ) is a popular research model. (nc3rs.org.uk)
  • Genome-wide chemical mutagenesis screens in the zebrafish (Danio rerio) have led to the identification of novel genes affecting vertebrate erythropoiesis. (bloodjournal.org)
  • 2 3 Many of the genes known to regulate erythropoiesis in mammals have been identified in another vertebrate animal model, the zebrafish (Danio rerio) . (bloodjournal.org)
  • Agillent׷ Zebrafish Promoter ChIP-on-chip Microarray 2-slide set enables identification of Danio rerio DNA binding proteins by combining chromatin IP pull-down assays with DNA microarray location analysis. (agilent.com)
  • Long-term repeatability of behaviours in zebrafish ( Danio rerio ). (otago.ac.nz)
  • Mitochondrial genome diversity among six laboratory zebrafish ( Danio rerio ) strains. (otago.ac.nz)
  • Zebrafish embryos grow their organs the same way as humans, only 20 times faster and one zebrafish pair generates about 200 eggs per week. (roche.com)
  • While most of the genes´ functions were not known, the MIT study showed that almost all of them led to brain abnormalities when eliminated from zebrafish embryos. (redorbit.com)
  • Because of the optical transparency of the embryos, small size at maturity and ease of culture, Zebrafish has become a popular organism to study embryonic development for biologist worldwide. (google.com)
  • Xenotransplantation of human cancer cells in embryos or adult zebrafish presents the advantage of following cancer cell behavior in vivo. (nih.gov)
  • Finally, zebrafish embryos are used in molecule screens and contribute to the identification of novel anti-cancer therapeutic strategies. (nih.gov)
  • Toxicological and pharmacological researchers have seized upon the many benefits of zebrafish, including the short generation time, well-characterized development, and early maturation as clear embryos. (springer.com)
  • Using the Tanguay lab Tropical 5D zebrafish line (T5D), we performed whole genome sequencing on a large group ( n = 276) of individual zebrafish embryos. (springer.com)
  • 2013 ). There are many benefits to using zebrafish in developmental studies, including early maturation as clear embryos that are amenable to easily observable morphological endpoints, short generation time, and well-characterized development that is conserved across species during the phylotypic period (Kimmel et al. (springer.com)
  • According to FDA research biologist Jyotshna Kanungo, Ph.D., "Using the embryos of zebrafish as models, we study how various drugs and chemicals affect the organs and systems. (fda.gov)
  • Using transgenic (genetically-altered) zebrafish embryos, scientists are investigating the effect of copper nanoparticles-frequently used in medical devices, paints and fabrics-on biological systems. (fda.gov)
  • Deneke's current work involves using Zebrafish, which are used because the eggs are fertilized and develop outside the mother's body and the embryos are nearly transparent. (forbes.com)
  • 2 Zebrafish embryos develop much more rapidly than mammals, and thus using zebrafish embryos as a model organism is efficient for toxicological and other studies. (genengnews.com)
  • Unlike many other model organisms, one of the major advantages of zebrafish is that the embryos develop externally and are optically transparent. (genengnews.com)
  • Also, adult zebrafish can produce hundreds of embryos per day. (genengnews.com)
  • 3 General toxicology screens can capture a broad range of phenotypes in wild-type (WT) zebrafish embryos. (genengnews.com)
  • Zebrafish embryos can be housed in individual microplate wells for live-animal assays. (acs.org)
  • We set up an experimental system to study the zIFN system in the course of a viral infection of zebrafish embryos. (mendeley.com)
  • The zebrafish homologue of the human myeloperoxidase (MPO) gene, which is specific to cells of the neutrophil lineage, was cloned and used to synthesize antisense RNA probes for in situ hybridization analyses of zebrafish embryos. (bloodjournal.org)
  • By exposing zebrafish embryos to the thyroid hormone triiodothyronine (T3) we showed that exposure accelerates ossification of craniofacial elements including the opercle and ceratohyal in a dose-dependent manner. (wur.nl)
  • of human coding genes have an equivalent in zebrafish. (roche.com)
  • Very recently, a number of methods have been optimised that simplify the genetic engineering of these little fish, and allow them to express a variety of human and/or disease relevant genes in zebrafish larvae. (roche.com)
  • Contrary to the fruit fly, Drosophila, and the worm, C. Elegans, which have been pivotal in our understanding of genes and phenotypes, zebrafish are vertebrates, and therefore much more relevant for human physiology in health and disease. (roche.com)
  • In particular, Massachusetts Institute of Technology ( MIT ) researchers recently revealed that they took a fresh approach to understanding the roles of genes linked to autism and demonstrated how zebrafish could be utilized in examining the genes that contribute to human brain disorders. (redorbit.com)
  • As such, Sive and other researchers began looking at zebrafish genes that were analogous to the human genes found in region 16p11.2. (redorbit.com)
  • Image 2 (below): Zebrafish with certain genes turned off during embryonic development (center and right images) showed abnormalities of brain formation (top row) and axon wiring (bottom row). (redorbit.com)
  • In the early 1980s, researchers managed to breed zebrafish with identical genes, known as homozygotes. (mpg.de)
  • As a vertebrate, the zebrafish has many genes that have the same, or similiar, functions in mammals and thus also in humans. (mpg.de)
  • Over the years, studies in zebrafish have enabled discovery of novel genes, pathways and models of human diseases in addition to understanding mechanisms underlying genome evolution. (google.com)
  • Since we introduced the zebrafish model for the study of hemostasis and thrombosis, other groups have adapted this model to study genes that are associated with thrombocyte function and a few novel genes have also been identified. (hindawi.com)
  • Noting the "relative ease and low costs of transgenesis"""putting human genes into zebrafish""and the unique benefits of working with zebrafish, especially related to imaging, genetics, and transplantation, Dr. Leach predicts that, "Future zebrafish cancer research exploiting these fundamental advantages will be especially likely to generate novel insights not achievable using other model systems," in his Introduction to the issue entitled, "Pisces and Cancer: The Stars Align. (redorbit.com)
  • The predicted GST genes of common carp were named based on their zebrafish orthologs, corrected by phylogenetic topologies. (thefreedictionary.com)
  • Sequencing revealed that 71.4% of human genes have at least one zebrafish ortholog. (uniprot.org)
  • Currently the zebrafish genome is thought to have more than 26,000 protein-coding genes. (uniprot.org)
  • Functional investigation of a subset of these genes, fgf10a, tgfb2, pax9, and smad5 revealed their necessity in zebrafish palatogenesis. (nih.gov)
  • Albert Pan (left), an associate professor at the Fralin Biomedical Research Institute, and Manxiu 'Michelle' Ma, a research associate in the Pan lab, were part of a team of scientists who worked with zebrafish to discover that genes linked to autism spectrum disorder and other brain abnormalities may be playing a role in people who cannot control their eye movements. (nih.gov)
  • Researchers studying zebrafish have found that genes linked to autism spectrum disorder and other developmental brain abnormalities may be playing a role in people who cannot control their eye movements. (nih.gov)
  • Harvesting lab-raised zebrafish based on their size led to differences in the activity of more than 4,000 genes, as well as changes in allele frequencies of those genes, in the fish that remained. (the-scientist.com)
  • Participants chronicled their use of zebrafish to assess drug toxicity and efficacy, to find bioactive small molecules, and even to find genes coding for potential new drug targets. (acs.org)
  • Postdoctoral fellow Zurab Tsetskhladze, who performed the zebrafish experiments, tested this method with two genes that affect skin color. (innovations-report.com)
  • The expression of zebrafish homologues was also examined in 2 other mammalian hematopoietic genes, Pu.1 , which appears to initiate a commitment step in normal mammalian myeloid development, and L-Plastin , a gene expressed by human monocytes and macrophages. (bloodjournal.org)
  • The results demonstrate a high level of conservation of the spatio-temporal expression patterns of these genes between zebrafish and mammals. (bloodjournal.org)
  • 13 This conservation of the fundamental mechanisms controlling erythropoiesis between mammals and zebrafish 4 raises the possibility that this powerful genetic system could be applied to uncover new classes of genes required in the normal development of granulocyte/macrophage cell lineages during vertebrate myelopoiesis. (bloodjournal.org)
  • Scientists from the Duke University analyzed all of the zebrafish genes whose activity suddenly changed immediately following a spinal injury. (wingsforlife.com)
  • With the help of co-author PSC's Art Wetzel, they led an international collaboration that used these images to reconstruct specific nerve cells that spanned nearly the entire larval zebrafish brain. (psc.edu)
  • Our goal [was] to develop techniques that allow researchers to examine the morphology and circuit connectivity of any neuron in the brain of a larval zebrafish at about five days after fertilization. (psc.edu)
  • The research team led by Dr Stephen Renshaw, Senior Clinical Lecturer in the Clinical Academic Unit of Respiratory Medicine at the University, has set-up a system for drug screening after finding important parallels between inflammation in the 3mm long larval fish (a similar stage to a tadpole) and in humans - proof that the zebrafish can be used to find anti-inflammatory drugs. (medicalnewstoday.com)
  • The rapid trajectories of Vibrio cholerae bacteria, shown in blue, are shown inside the gut of a larval zebrafish. (eurekalert.org)
  • Here we present an automated high-throughput system for measuring nonassociative learning behaviors in larval zebrafish. (pnas.org)
  • Using this system, we report that spaced training blocks of repetitive visual stimuli elicit protein synthesis-dependent long-term habituation in larval zebrafish, lasting up to 24 h. (pnas.org)
  • Although we found extensive functional conservation of short-term learning between larval zebrafish and mammalian models, we also discovered several compounds with previously unknown roles in learning. (pnas.org)
  • Larval zebrafish execute a repertoire of simple, well-defined, and stereotyped sensorimotor behaviors that have accessible and characterized circuitry and provide a vertebrate system amenable to large-scale forward genetic and chemical screening ( 17 ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ - 24 ). (pnas.org)
  • Here we developed a battery of behavioral assays in larval zebrafish to determine whether behavioral profiles can provide sufficient phenotypic resolution to identify and classify psychiatric drugs. (nature.com)
  • Zebrafish have the ability to regenerate many of their tissues including fins, skin, heart and, in larval stages, brain. (uniprot.org)
  • The facility is equipped with 48 racks which hold standard sized adult zebrafish tanks, a three rack nursery space for larval fish, and a quarantine space containing two stand-alone housing systems. (bidmc.org)
  • Researchers unveil the neural basis of alertness in larval zebrafish. (the-scientist.com)
  • According to the authors, this was the first time abnormal behavior of larval zebrafish to cadmium and aluminum has been compared. (noldus.com)
  • The zebrafish is a widely used model organism for genetic , genomic , and developmental studies, and ZFIN provides an integrated interface for querying and displaying the large volume of data generated by this research. (wikipedia.org)
  • Through genetic modification you can make zebrafish glow in the dark in different colours. (roche.com)
  • Genetic screens in Zebrafish have led to the discovery of large number of mutations that disrupt embryonic development. (google.com)
  • Zebrafish develops cancers spontaneously, after chemical mutagenesis or through genetic manipulations. (nih.gov)
  • These data were used to compare observed population genetic variation across species (humans, mice, zebrafish), then across lines within zebrafish. (springer.com)
  • We establish T5D as a model that is representative of diversity levels within laboratory zebrafish lines and demonstrate that experimental design and analysis can exert major effects when characterizing genetic diversity in heterogeneous populations. (springer.com)
  • Keeping this in mind we introduced zebrafish, a vertebrate genetic model to study platelet function. (hindawi.com)
  • In the paper entitled "Identification of a Heritable Model of Testicular Germ Cell Tumor in the Zebrafish," authors Joanie Neumann, Jennifer Dhepard Dovey, Garvin Chandler, Liliana Carbajal, and James Amatruda, describe the development of a zebrafish model that carries a genetic mutation making the fish highly susceptible to the development of testicular tumors. (redorbit.com)
  • Due to its prolific reproduction and the external development of the transparent embryo, the zebrafish is the prime model for genetic and developmental studies, as well as research in genomics. (elsevier.com)
  • The zebrafish is currently being utilised to study novel genetic factors hypothesised to contribute to osteoporosis. (timesofmalta.com)
  • This second volume covers advances in forward and reverse genetic techniques, provides an update on the zebrafish genome and gene/mutant mapping technologies, examines the new systems for efficient transgenesis in the zebrafish, provides an in-depth view of informatics and the emerging field of comparative genomics, and considers the extensive infrastructure now available to the zebrafish community. (elsevier.com)
  • Recent studies have shown that the zebrafish palate, or anterior neurocranium, is under similar genetic control to the amniote palatal skeleton. (nih.gov)
  • To compare the relative recombination rates during meiosis in male and female zebrafish, we constructed a genetic map based on male meiosis. (genetics.org)
  • We used a forward genetic screen in zebrafish to identify the transcription factor mafba as essential for lymphatic vessel development. (uu.se)
  • Owing to a high quality genome reference sequence and its genetic and embryological tractability the zebrafish is a vertebrate model especially suited for large scale studies. (ashg.org)
  • The zebrafish is a potential tool for testing one class of unique individual genetic differences found in humans, and may yield information helpful for the emerging field of personalized medicine, according to a team led by Penn State College of Medicine scientists. (innovations-report.com)
  • Zebrafish can be used as a model to understand what biological effects result from these genetic mutations. (innovations-report.com)
  • The zebrafish is a good choice because of its similarity to humans as a vertebrate, its transparency as an embryo and the powerful genetic tools available in this model organism. (innovations-report.com)
  • Cheng's lab works with zebrafish to study genetic differences that contribute to human skin color. (innovations-report.com)
  • The morphologic and molecular genetic evidence presented here supports the zebrafish as an informative model system for the study of normal and aberrant human myelopoiesis. (bloodjournal.org)
  • We (humans) share 70 per cent of our genetic code with zebrafish, and the human CTGF protein is nearly 90% similar to the one from the zebrafish. (wingsforlife.com)
  • ZFIN's community wiki gives zebrafish researchers the ability to share information about laboratory protocols and antibodies. (wikipedia.org)
  • To this end, researchers at Harvard and PSC used PSC-developed software and hardware to create a 3D map of the zebrafish larva brain-the first whole vertebrate brain so reconstructed. (psc.edu)
  • laboratories and researchers working on zebrafish. (tu-braunschweig.de)
  • Using zebrafish that share genetics similar to humans, researchers discovered two enzymes that, when combined, could be involved in the earliest stages of cancer, the Salt Lake City-based Institute announced Wednesday. (upi.com)
  • Tropical zebrafish have helped researchers at the University of Sheffield pave the way for the discovery of new anti-inflammatory drugs to treat illnesses such as chronic obstructive pulmonary disease (COPD) and asthma . (medicalnewstoday.com)
  • In a series of studies, researchers tested how zebrafish behaved after receiving doses of Lactobacillus plantarum, a common bacteria found in yogurt and probiotic supplements. (thefreedictionary.com)
  • Researchers develop a new method to highlight specific cells that reside in the lens of a zebrafish. (the-scientist.com)
  • To explore whether this gene might play a role in preventing tissue regeneration in humans, the researchers added human ARF to the zebrafish genome and assessed how it affected the fishes' normal ability to regrow damaged fins after injury. (ucsf.edu)
  • As one of 22 early-career researchers selected as Pew Biomedical Scholars in 2011 , Morris opted to watch eye development-and its potential mishaps-in action within zebrafish. (pewtrusts.org)
  • Researchers from the University of Pittsburgh are using zebrafish to study the biological mechanisms that lead to intestinal inflammation, as often seen in IBD, providing additional understanding that may allow development of better therapies. (newswise.com)
  • Well, not exactly, but for the first time researchers have followed the growth of each cell in a zebrafish embryo as it grew from one to 20,000 cells strong. (trendhunter.com)
  • The researchers found that the change made no difference in function in zebrafish. (innovations-report.com)
  • ZFIN is home to the Zebrafish Model Organism Database-A directory for researchers to access zebrafish-related resources. (otago.ac.nz)
  • Researchers hope that better understanding the repair mechanisms in zebrafish could eventually lead to new therapies for people with neurodegenerative conditions. (ed.ac.uk)
  • At Oregon, Douglas was a member of the Cognitive and Decision Sciences Institute(Director, 1995-1998) and led the technology team that conceived of and built the Zebrafish Information Network, an international online multimedia database of information for zebrafish researchers. (wikipedia.org)
  • We characterized zebrafish thrombocytes and established functional assays study not only their hemostatic function but to also their production. (hindawi.com)
  • Authors Leonard Zon, PhD, and Alison Taylor, PhD, from Harvard Medical School and Children's Hospital Boston present the concepts and techniques relevant to zebrafish transplantation assays. (redorbit.com)
  • They describe how tumor transplantation has been used to study leukemia, rhabdomyosarcoma, and melanoma in the paper "Zebrafish Tumor Assays: The State of Transplantation. (redorbit.com)
  • Despite the abundance of established habituation learning assays for adult rodent and zebrafish models, scaling these assays for systematic approaches is challenging given the inherent complexity and variability of adult behaviors, as well as the time required to train and test large numbers of animals ( 10 ⇓ ⇓ ⇓ ⇓ ⇓ - 16 ). (pnas.org)
  • Although some studies have explored the capacity of zebrafish larvae for various forms of short-term learning and sensory conditioning, these assays have not been adapted to systematic approaches ( 25 ⇓ - 27 ). (pnas.org)
  • Zebrafish combine the convenience and throughput of assays carried out in a multiwell plate with the benefits of performing assays in a fully functioning organism. (genengnews.com)
  • To produce in vivo phenotypes in zebrafish assays, compounds must exhibit the ability to be absorbed, reach the target tissue, and avoid rapid metabolism and excretion. (genengnews.com)
  • Chemists' burgeoning interest in using zebrafish to complement other animal models and cell-based assays motivated an afternoon session sponsored by the Division of Chemical Toxicology at the American Chemical Society national meeting in Boston last month, according to organizer Peter C. Dedon , a professor of toxicology and biological engineering at Massachusetts Institute of Technology. (acs.org)
  • Several informal 'roundtable' discussions will cover the design and execution of mutant screens/reverse genetics, transgenesis, disease modeling, zebrafish breeding and husbandry, as well as data management and figure construction. (mbl.edu)
  • A major difference from many model organisms is that standard husbandry practices in zebrafish are designed to maintain population diversity. (springer.com)
  • Since 2011, a full time manager staffs the facility and is available for assistance with access, training and general Zebrafish husbandry questions. (bidmc.org)
  • The student will receive a thorough education in molecular biology, zebrafish husbandry, fluorescence microscopy and handling of large datasets. (uu.se)
  • Prior knowledge and experience in fluorescence microscopy, bioinformatics, programming, zebrafish husbandry and/or image-based analyses are a bonus. (uu.se)
  • This video will provide an overview of zebrafish husbandry and maintenance in the lab. (jove.com)
  • The organ make up and general body plan of a zebrafish is similar to humans because a zebrafish is a vertebrate. (roche.com)
  • While genetically distant from humans, nonetheless the vertebrate zebrafish has comparable organs and tissues that make it the model organism for study of vertebrate development. (elsevier.com)
  • They were able to show that a number of these drugs worked in zebrafish, thereby establishing that zebrafish could be used to identify new potential therapeutics for humans. (medicalnewstoday.com)
  • Significantly, the zebrafish ECM were also found to offer stress-protection to specialized cells that make up the heart muscle in humans, called cardiac myocytes. (thefreedictionary.com)
  • Surrounded by 288 fish tanks in her lab at NCTR, Kanungo notes that unlike the fruit flies and the nematode worm, other popular species studied in laboratories, zebrafish are vertebrates (have a backbone), as are humans. (fda.gov)
  • For example, the hearts of zebrafish and humans both have chambers and rhythmically pump oxygen-carrying blood through the body. (fda.gov)
  • Zebrafish have neuromasts (small sensory patches) similar to those lining the inner ear of humans. (fda.gov)
  • The necessary molecular transitions required for development take place in similar sequences but occur much more rapidly in zebrafish compared to humans. (genengnews.com)
  • Zebrafish are close enough to humans on a molecular level to be relevant, and their development is fast enough to make it a convenient model to employ for investigation. (genengnews.com)
  • Insights from creatures like zebrafish and salamanders, which routinely regrow damaged tails, limbs, jaws and even hearts, may one day endow humans with heightened regenerative abilities. (ucsf.edu)
  • Now, as a plastic surgeon and stem cell researcher, he believes that insights from creatures like zebrafish and salamanders, which routinely regrow damaged tails, limbs, jaws and even hearts, may one day endow humans with heightened regenerative abilities. (ucsf.edu)
  • And unlike humans, adult zebrafish can regenerate damaged tissues and organs, including eyes. (pewtrusts.org)
  • In the current study, two of the amino acid differences that Cheng has shown in prior studies to contribute to light skin color in humans prevented the zebrafish color from darkening. (innovations-report.com)
  • Zebrafish are increasingly used as a model for neurotoxic effects because the neuropathological behavior is relatable to that shown in humans. (noldus.com)
  • At the molecular level, the biological similarity between zebrafish and humans is striking (Spoorendonk et al. (wur.nl)
  • The focus of the present paper is on spinal cord regeneration in adult zebrafish. (hindawi.com)
  • Unlike mammals, zebrafish retains radial glia, a nonneuronal cell type in their adult central nervous system. (hindawi.com)
  • In addition to being small, adult zebrafish are easy to maintain compared to mammalian models, such as mice and rats. (genengnews.com)
  • Just why zebrafish have an abundant supply of adult stem cells to regenerate their retinas, while they are rare in mammals, remains a mystery but Limb suspects it is because mammals have a limiting system to stop proliferation. (health24.com)
  • A three-dimensional reconstruction of the entire depth of the front part of the brain (forebrain) of an intact living adult zebrafish imaged with three-photon microscopy (3PEF). (cornell.edu)
  • In previous studies, the team in Naples showed some neurotoxic effects of cadmium and aluminum in adult zebrafish during embryological development. (noldus.com)
  • Genetically engineered mice and zebrafish enabled new research towards treatments for pancreatic and skin cancers, respectively. (zdnet.com)
  • We evaluated whether alterations in the balance between ERK1/2 and PI3K signaling pathways could stimulate arterial formation in the setting of defective arterial morphogenesis in mice and zebrafish. (jci.org)
  • While this work has only just begun, it may eventually shed new light on past studies of zebrafish behavior-and point the way toward a better understanding of more complex brains, such as ours. (psc.edu)
  • Epiboly plays a prominent role in zebrafish gastrulation and studies of zebrafish epiboly have provided insights into basic cellular properties and mechanisms of morphogenesis that are widely used in animal development. (nih.gov)
  • Robotic automation specialists Hudson Robotics, along with Johns Hopkins University, won an NIH grant to develop a commercially viable high-throughput screening (HTS) system for in vivo studies of zebrafish. (genengnews.com)
  • Zebrafish, a four centimeter long fish native to Indian rivers, has attracted considerable scientific interest worldwide primarily as a non-mammalian vertebrate model organism. (google.com)
  • Because repeated observations for the replicate chemicals in the Phase I data set were not available for mammalian or zebrafish data, comparisons between species were analyzed using averaged C. (thefreedictionary.com)
  • Several studies have found strikingly similar mammalian and zebrafish toxicology profiles. (genengnews.com)
  • Here we present the identification and characterization of a zebrafish APC subset strongly resembling mammalian DCs. (pnas.org)
  • 4 Homologues of known mammalian hematopoietic transcription factors, such as gata-1, gata-2, c-myb , scl, fli-1, Imo2 , and cbfb are all appropriately expressed during zebrafish embryogenesis. (bloodjournal.org)
  • Scientists only discovered the zebrafish, which is a member of the minnow family, for their own purposes in the late 1960s. (mpg.de)
  • Why do scientists study zebrafish? (mpg.de)
  • This book, one of two new volumes in the Reliable Lab Solutions series dealing with zebrafish, brings together a robust and up-to-date collection of time-tested methods presented by the world's leading scientists. (elsevier.com)
  • Zebrafish are useful to scientists because they have a fully functioning simple heart and circulatory system. (bbc.co.uk)
  • Scientists at the University of California, San Diego (UCSD) School of Medicine are working with transparent zebrafish to study cancer cells in action. (medindia.net)
  • The UCSD team developed an immuno-suppressed zebrafish that expresses green fluorescent protein (commonly known as GFP) only in its blood vessels, allowing scientists to view the tumor-induced blood vessel formation, or angiogenesis. (medindia.net)
  • The ability of zebrafish to regenerate damaged retinas has given scientists a clue about restoring human vision and may lead to an experimental treatment for blindness. (health24.com)
  • Mutant zebrafish called "Casper" are transparent, allowing scientists to easily monitor cancer growth. (bu.edu)
  • Also, since scientists have used zebrafish to model disease for decades, their genetics are well-understood and easily manipulated. (bu.edu)
  • The largest survey to-date on the use and care of zebrafish in research, conducted by scientists at the NC3Rs, AstraZeneca and University of Plymouth. (nc3rs.org.uk)
  • Scientists have discovered that a hormone called serotonin - better known for its role as a mood booster - can help zebrafish to recover from a spinal cord injury. (ed.ac.uk)
  • Even more interestingly, when scientists injected human CTGF in to a zebrafish, they observed that the spinal cord could still be regenerated. (harunyahya.com)
  • The study, which was conducted in the University's MRC Centre for Developmental and Biomedical Genetics, is the first published proof of principle work to show that zebrafish models can be used to find anti-inflammatory drugs. (medicalnewstoday.com)
  • Consequently, the zebrafish is an efficient and convenient model for many developmental and toxicological studies. (genengnews.com)
  • Developmental hemapoiesis in zebrafish and Antarctic fishes. (elsevier.com)
  • Zebrafish represent an important vertebrate model species in developmental biology. (wur.nl)
  • Zebrafish larvae display a high amount of developmental plasticity, enabling an adaptive response to training. (wur.nl)
  • In determining if this approach could also be used to clarify the molecular genetics of myelopoiesis, it was found that the developmental hierarchy of myeloid precursors in the zebrafish kidney is similar to that in human bone marrow. (bloodjournal.org)
  • Furthermore, transgenic zebrafish with GFP-tagged thrombocytes have been developed which helped to study the production of thrombocytes and their precursors as well as their functional roles not only in hemostasis but also hematopoiesis. (hindawi.com)
  • Jun Chen and Jinrong Peng, from Zhejian University (China), describe the use of transgenic zebrafish to understand the roles that different naturally occurring forms of the tumor suppressor gene p53 play in regulating cell cycle, metabolism, organ development, and cell aging and death. (redorbit.com)
  • By watching human breast cancer cells in real time in the live transgenic zebrafish, we were able to determine that two proteins are required in order for breast tumor cells to complete the most critical step of metastasis - entering the blood vessels," said Konstantin Stoletov, Ph.D., of the department of pathology at the UC-San Diego School of Medicine, first author of the paper. (medindia.net)
  • In fact, about 71% of human proteins have an ortholog in zebrafish. (genengnews.com)
  • The aim of this thesis was to analyze the composition of the extracellular matrix in zebrafish, in order to enable the identification of potential key regulatory proteins. (wur.nl)
  • After the identification of potential regulatory proteins in the developing zebrafish skeleton during the MS-based approach, the protein carboxypeptidase Z (Cpz) was selected for further analysis. (wur.nl)
  • This is achieved through our partners, the Zebrafish International Resource Center (ZIRC) and the European Zebrafish Resource Center (EZRC), who provide distribution services for the zebrafish community. (sanger.ac.uk)
  • Collectively, these results suggest that the gene regulatory networks regulating palatogenesis may be conserved across vertebrate species, demonstrating the utility of zebrafish as a model for palatogenesis. (nih.gov)
  • This figure is a composition of two intercalated confocal micrographs showing the detail view of the habenular nucleus of a wild-type and a mutant zebrafish embryo. (europeana.eu)
  • Prakash Thakur, a research associate working with Nathan Bahary, M.D., Ph.D., described a mutant zebrafish strain that shows many pathological characteristics similar to IBD, including inflammation, abnormal villous architecture, disorganized epithelial cells, increased bacterial growth and high numbers of dying cells in the intestine. (newswise.com)
  • He started with an equivalent of the broken car part: mutant zebrafish with lighter pigment cells. (innovations-report.com)
  • First, Tsetskhladze confirmed that by injecting normal messenger RNA (ribonucleic acid) into the mutant zebrafish, the lighter pigment cells become "cured" -- or darker --like those of a normal zebrafish. (innovations-report.com)
  • In order to explore the role of cpz in zebrafish development, a loss-of-function mutant for zebrafish cpz was generated via TALEN-mediated mutagenesis. (wur.nl)
  • The charity hopes to harness the miraculous healing abilities of zebrafish, a species that is able to mend its own heart muscle. (bbc.co.uk)
  • Zebrafish are also closely related to the genus Devario, as demonstrated by a phylogenetic tree of close species. (wikipedia.org)
  • The unusually cold temperature was at one of the highest known zebrafish locations at 1,576 m (5,171 ft) above sea level, although the species has been recorded to 1,795 m (5,889 ft). (wikipedia.org)
  • Zebrafish is a quarterly peer-reviewed journal focusing on research using the zebrafish and related species. (wikipedia.org)
  • Given the multitude of (molecular) tools available for the zebrafish, this species promises to be very useful in further elucidating the mechanisms of muscle, skeletal, and cardiovascular adaptations to prolonged exercise. (wur.nl)
  • This first proteomic analysis of the zebrafish skeleton revealed the homology between the zebrafish and the skeleton of other vertebrate species including mammals. (wur.nl)
  • The zebrafish skeleton displays remarkable resemblance to that of other vertebrate species with regards to composition, regulatory components and hormonal response. (wur.nl)
  • The Zebrafish Mutation Project (ZMP) aims to create a knockout allele in every protein--coding gene in the zebrafish genome, using a combination of ENU mutagenesis, whole exome enrichment and Illumina sequencing, in addition to a targeted CRISPR/Cas9 approach. (sanger.ac.uk)
  • Zebrafish Mutation Project: Functional Genomics of Disease. (ashg.org)
  • Previously having established methods to generate and identify disruptive zebrafish point mutations on a genome wide scale the Zebrafish Mutation Project is now assigning biological function to every protein-coding gene in the zebrafish genome. (ashg.org)
  • This is really nice work that shows the importance of zebrafish in revealing disease mechanisms related to human mental disorders - in this case, autism," mentioned Su Guo , an associate professor of pharmaceutical sciences at the University of California at San Francisco who´s unaffiliated in the study, in the statement. (redorbit.com)
  • Zebrafish epiboly: mechanics and mechanisms. (nih.gov)
  • Recent technological development of exquisite molecular tools in zebrafish, such as cell ablation, lineage analysis, and novel and substantial microarray, together with advancement in stem cell biology, allowed us to investigate how progenitor cells contribute to the generation of appropriate structures and various underlying mechanisms like reprogramming. (hindawi.com)
  • Using the antipsychotic drug haloperidol as a test case, we found that behavioral profiles of haloperidol-treated zebrafish could be used to identify previously uncharacterized compounds with desired antipsychotic-like activities and multitarget mechanisms of action. (nature.com)
  • These findings indicate that zebrafish will be useful for genetically dissecting the molecular mechanisms of cardiac regeneration. (sciencemag.org)
  • At the 2012 International Zebrafish Development Conference, held June 20-24 in Madison, Wisconsin, numerous presentations highlighted the utility of the zebrafish for examining the basic biological mechanisms underlying human disorders and identifying potential treatment approaches for an impressive array of organ and systemic diseases. (newswise.com)
  • Understanding how zebrafish are able to repair damaged nerves could one day help us to trigger similar mechanisms in human stem cells. (ed.ac.uk)
  • The team uses zebrafish to study the neuronal mechanisms of these heavy metals in connection to neurodegenerative and neuromuscular diseases. (noldus.com)
  • Mechanisms of social buffering of fear in zebrafish. (noldus.com)
  • International Zebrafish Society is an umbrella group that helps to facilitate the exchange of information and resources within the zebrafish community. (otago.ac.nz)
  • The International Zebrafish Society (IZFS) was started in 2015 and IZFS now organizes these meetings. (genetics-gsa.org)
  • Information in ZFIN is tightly linked to the web resources of the Zebrafish International Resource Center ( ZIRC ), the China Zebrafish Resource Center ( CZRC ), and so on, which maintain and provide zebrafish-related research resources, materials and services. (wikipedia.org)
  • ZIRC is the Zebrafish International Resource Centre-A stock centre, holding the various strains of zebrafish centrally. (otago.ac.nz)
  • Zebrafish: Methods and Protocols, Second Edition guides readers through methods for mutagenesis and genome editing in zebrafish, applications of GFP-expressing transgenic fish, techniques for cancer models, imaging of infection and host-pathogen interactions, metabolism and transport of lipids, and the structure and function of neural circuits and their role in generating behavior. (springer.com)
  • Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring. (otago.ac.nz)
  • Following that trend, these zebrafish also showed increasingly uncontrolled behavior (meander) with increased doses. (noldus.com)
  • Being social animals, zebrafish are an interesting model for studying psychiatric disorders that affect social behavior, such as schizophrenia and autism. (noldus.com)
  • Shoaling is a straightforward expression of social behavior in zebrafish. (noldus.com)
  • The study of zebrafish behavior can include a lot of parameters and assessing these is a lot easier with the right software. (noldus.com)
  • Scientific Reports, 2017 ) tracked freezing behavior and erratic movements of zebrafish in detail, and found that zebrafish handled an aversive stimulus better if they are not alone. (noldus.com)
  • From these tracks detailed analysis of freezing behavior and erratic movements was performed to assess fear behavior in the zebrafish. (noldus.com)
  • Washington, Sep 5 (IANS) Loud noise is known to irreversibly damage hair cells within the inner ear of mammals and cause deafness, but the ability of zebrafish to regrow these cells holds hope, new research says. (thaindian.com)
  • Together, these studies suggest that the cellular constituents responsible for antigen presentation are remarkably conserved from teleosts to mammals, and indicate that the zebrafish may serve as a unique model to study the origin of APC subsets and their evolutionary role as the link between the innate and adaptive immune systems. (pnas.org)
  • Here, we have addressed the biology of DCs in the zebrafish, a small cyprinid teleost that features an immune system similar to that of mammals ( 11 ). (pnas.org)
  • The question of whether the regenerative powers of zebrafish and salamanders represent ancient abilities that mammals have lost, perhaps in exchange for advanced tumor-suppression systems remains an open question for biologists. (ucsf.edu)
  • 7 18 19 The earliest site of zebrafish hematopoiesis is the ICM, a region analogous to the blood islands of the yolk sac in mammals. (bloodjournal.org)
  • Mammals cannot regenerate their complex nervous tissue but small, tropical zebrafish can repair a severed spine in eight weeks. (wingsforlife.com)
  • 5-9 Chemical mutagenesis screens in this organism have resulted in the isolation of numerous zebrafish lines containing mutations that affect both embryonic and definitive erythropoiesis. (bloodjournal.org)
  • Zebrafish can develop a form of the disease genetically similar to human skin cancer tumors. (zdnet.com)
  • Furthermore, zebrafish cancers are similar to human tumors at the histological and molecular levels allowing the study of tumor initiation, progression and heterogeneity. (nih.gov)
  • SALT LAKE CITY, Dec. 24 (UPI) -- A study of zebrafish has revealed ways to potentially slow or prevent the onset of cancerous tumors, the Huntsman Cancer Institute in Utah says. (upi.com)
  • The zebrafish, a translucent fish often used as a model of human development and disease, offers unique advantages for studying the cause, growth, and spread of tumors using strategies and methods presented in the current "Cancer Biology" special issue of Zebrafish, a peer-reviewed journal published by Mary Ann Liebert, Inc. ( http://www.liebertpub.com/ ). (redorbit.com)
  • A particular advantage of using zebrafish to study cancer biology is the ability to transplant human tumors into the fish using well-established methods. (redorbit.com)
  • Zebrafish larvae transplanted with patients' tumors respond as their human donors do to chemotherapy. (the-scientist.com)
  • 8. Transgenesis and Gene Trap Methods in Zebrafish by Using the Tol2 Transposable Element (Koichi Kawakami)9. (elsevier.com)
  • The zebrafish pronephric kidney provides a simple, yet powerful, model system to better understand the conserved molecular and cellular progresses that drive nephron formation, structure, and function. (springer.com)
  • Here, we review work on the molecular and cellular basis of zebrafish epiboly in order to identify unifying themes and to highlight some of the current open questions. (nih.gov)
  • Sensory neurons in the tip of the zebrafish nose respond to molecular signals released from food sources. (the-scientist.com)
  • Thus, the mpo gene should provide a useful molecular probe for identifying zebrafish mutants with defects in granulopoiesis. (bloodjournal.org)
  • Additionally, the presentation will include information on how specific zebrafish strains are tracked in a laboratory setting, with specific reference to the collection of tail fin samples for DNA extraction and genotyping. (jove.com)
  • Our analysis of zebrafish forebrain mutants led to the discovery that the small protein Sonic Hedgehog (Shh) is a critical player in the early induction of the pituitary placode, as well as in the differentiation of a subset of endocrine cell types. (umass.edu)
  • A , Schematic of zebrafish NOX protein domains as determined by alignment to the human protein sequences. (jneurosci.org)
  • The human CTGF protein is nearly 90% similar to that of the zebrafish. (harunyahya.com)
  • By determination of the protein content in the zebrafish skeletal ECM with major changes in protein abundance during development we were able to identify various components of signaling pathways implicated in skeletogenesis. (wur.nl)
  • In this thesis we provide a first insight in the extracellular protein content of the zebrafish skeleton, identify a role for the Cpz protein in β-catenin independent (non-canonical) Wnt signaling during development and shows the effect of thyroid hormone on ossification during early zebrafish development. (wur.nl)
  • Zebrafish models are also amenable to high-throughput chemical compound screening, thereby enabling discovery of novel drug compounds. (google.com)
  • These advantages have led to an upward trend in high-throughput zebrafish chemical screens, especially toward screens of many chemicals using large quantities of fish (Usenko et al. (springer.com)
  • As small vertebrate animals, zebrafish are amenable to high throughput screening and require only small amounts of compounds in testing scenarios. (genengnews.com)
  • The hearts of zebrafish with mutations in the Mps1 mitotic checkpoint kinase, a critical cell cycle regulator, failed to regenerate and formed scars. (sciencemag.org)
  • Genetically engineered zebrafish could provide a quick way to test new drugs to prevent dangerous plaque buildup in the heart. (technologyreview.com)
  • In the last 10 to 15 years, as regenerative organisms like zebrafish have become genetically tractable to study in the lab, I became convinced that these animals might be able to teach us what is possible for human regeneration," Pomerantz said. (ucsf.edu)
  • Zebrafish floating head ( flh ) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. (nature.com)
  • Zebrafish reward mutants reveal novel tra. (mendeley.com)
  • These marvelous mutants, and others, are under the charge of Hui Feng, director of BU's Lab of Zebrafish Genetics and Cancer Therapeutics , and they may hold clues to treating breast cancer. (bu.edu)
  • This second edition details new emerging areas of zebrafish research focusing on genetics and genomics, techniques for developing and analyzing zebrafish disease models, and methods for neuroscience. (springer.com)
  • Culled from previously published chapters in Methods in Cell Biology and updated by the original authors where relevant, it provides a comprehensive collection of protocols describing the most widely used techniques relevant to the study of zebrafish genetics and genomics. (elsevier.com)
  • Zebrafish Model Organism Database. (wikipedia.org)
  • The zebrafish is an important and widely used vertebrate model organism in scientific research, for example in drug development, in particular pre-clinical development. (wikipedia.org)
  • Newswise - BETHESDA, MD - July 6, 2012 - Zebrafish, popular as aquarium fish, now have an important place in research labs as a model organism for studying human diseases. (newswise.com)
  • The zebrafish is a relatively new model organism in the field of skeletal development and primarily used as a powerful model for the identification of novel gene functions during skeletogenesis. (wur.nl)
  • The zebrafish is a derived member of the genus Brachydanio, of the family Cyprinidae. (wikipedia.org)
  • a relational database containing biological data that are curated from the scientific literature and that are directly submitted by zebrafish research laboratories (e.g. (wikipedia.org)
  • Zebrafish is being used in Roche research and early development for both safety and efficacy studies. (roche.com)
  • Roche is at the head of the class when it comes to the school of zebrafish research, and is pursuing the use of zebrafish in both safety and efficacy testing. (roche.com)
  • Yet, following this humble beginning, why has the zebrafish developed into one of the most popular model organisms for research? (mpg.de)
  • Instead, a combination of characteristics makes the zebrafish so attractive that countless labs around the world now use it for research: in the Max Planck Society alone at seven different Institutes. (mpg.de)
  • From the processes during embryonal development up to information processing in the brain - the zebrafish is a popular model organisms in basic research. (mpg.de)
  • Although cell culture and mouse models will remain a cornerstone of cancer research, the unique capabilities of the zebrafish outline the potential of this model for shedding light on cancer biology in vivo. (nih.gov)
  • Here, we review different involvements of the zebrafish model in cancer research. (nih.gov)
  • Zebrafish-so named for the speckled "stripes" along its side and originally found in the Ganges River in East India and Burma-have been making a splash in the world of scientific research for some time. (fda.gov)
  • The research showed that growth hormone is involved in this regeneration in zebrafish. (thaindian.com)
  • ZEBRAFISH, little freshwater tropical fish that populate pet-store aquariums, are making a splash in several arenas of drug discovery research. (acs.org)
  • Our research group studies lymphatic vessel formation in zebrafish, as a main model system. (uu.se)
  • Dr Caroline Brennan (QMUL) explains why zebrafish make excellent research models. (nc3rs.org.uk)
  • Find out about grants awarded to projects applying the 3Rs in zebrafish research. (nc3rs.org.uk)
  • The following links provide additional information on zebrafish and their role in research. (otago.ac.nz)
  • Fish for Pharma presents a short summary of why zebrafish make an ideal animal model for research. (otago.ac.nz)
  • Request a free demo for your zebrafish research. (noldus.com)
  • Watch the movie about zebrafish research at a glance and request a free demo! (noldus.com)
  • The use of zebrafish as a model in future research will undoubtedly increase our understanding of vertebrate skeletal development and disease. (wur.nl)
  • The Zebrafish Conference on Development and Genetics allows attendees to network with premier Zebrafish geneticists, forge new collaborations, and get updated on cutting-edge research in a diverse array of topics. (genetics-gsa.org)
  • This unique model is the only way to visualise these cells during inflammation, and given the small size of zebrafish, makes drug screens a practical prospect using this approach. (medicalnewstoday.com)
  • This success is only the first of a range of zebrafish drug screens, which I am hopeful will provide real benefits to health in the coming years. (medicalnewstoday.com)
  • Zebrafish are especially amenable to phenotype-based drug discovery (PDD) screens. (genengnews.com)
  • In fact, PDD screens performed on zebrafish have led to the identification of some lead compounds of therapeutic potential. (genengnews.com)
  • Using a technique developed by Lichtman's laboratory, he cut the front quarter of the zebrafish larva-a total length of 1 millimeter, or about 4 hundredths of an inch-into more than 18,000 slices. (psc.edu)
  • In 2009, Kanungo set up the zebrafish laboratory at NCTR. (fda.gov)
  • This volume of Methods in Cell Biology , the second of two parts on the subject of zebrafish, provides a comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 1999. (elsevier.com)
  • Due to their small size, large numbers of zebrafish can be housed in the laboratory at low cost. (jove.com)
  • Moreover, whether zebrafish larvae display long-term habituation, and thus the ability for memory storage and retrieval, is unclear. (pnas.org)
  • Ann Morris, a 2011 Pew Biomedical Scholar and assistant professor at the University of Kentucky, didn't know as a child that she would study zebrafish for clues on improving human vision, but she did know that one day she'd become a scientist. (pewtrusts.org)
  • Being a vertebrate, Zebrafish has blood, eye, heart, kidney and other biological processes that share many features of the human system. (google.com)
  • In the 1970s, then-UO professor George Streisinger discovered that zebrafish made an excellent model for humanlike biological processes. (thefreedictionary.com)
  • A zebrafish can even regrow parts of its heart. (roche.com)
  • The zebrafish is an alternative in vivo model which is currently being evaluated at Roche to study the effects of compounds on target organ toxicities. (roche.com)
  • Zebrafish are almost transparent during the early stages of life, allowing the in vivo observation of internal organs and tissues. (timesofmalta.com)
  • We took advantage of this experimental system to perform in vivo loss and gain of function analysis of candidate receptors of the class II helical receptor family and identified zCRFB1 and zCRFB5 as the two subunits of the zebrafish IFN receptor. (mendeley.com)
  • Zebrafish is an excellent animal model, which can repair several organs like damaged retina, severed spinal cord, injured brain and heart, and amputated fins. (hindawi.com)
  • The zebrafish embryo develops rapidly, with precursors to all major organs appearing within 36 hours of fertilization. (wikipedia.org)
  • Chen YH, Chang CF, Lai YY, Sun CY, Ding YJ, Tsai JN (2015) von Hippel-Lindau gene plays a role during zebrafish pronephros development. (springer.com)
  • This intensive two-week course for advanced graduate students, postdoctoral fellows, and independent investigators will focus on the development and genetics of zebrafish. (mbl.edu)
  • Zebrafish Wild Type Strain Genome was presented at the 6th European Zebrafish Genetics and Development Meeting at Rome, Italy. (google.com)
  • The Zebrafish Community meets biannually at the ' International Conference on Zebrafish Development and Genetics ', which usually takes place in Madison/Wisconsin, USA. (tu-braunschweig.de)
  • The biannual European Zebrafish Genetics and Development Meeting alternates with the International Conference and takes place at changing locations throughout Europe. (tu-braunschweig.de)
  • Zebrafish are useful for studying how left-right brain asymmetries arise during embryonic development and how the resultant asymmetric neuronal circuitry ultimately impacts on function and behaviour. (europeana.eu)
  • Zebrafish are an excellent vertebrate model for investigating normal and abnormal development. (genengnews.com)
  • This elaborate but easy-to use website details the complete vascular anatomy of the zebrafish embryo and larva at every stage of development from 1 to 7 days post-fertilization. (merlot.org)
  • Our lab has previously reported the development of a reliable conditioned place preference paradigm for zebrafish. (mendeley.com)
  • Ontology term enrichment analysis on gene ontology (GO) annotations combined with the zebrafish anatomical and development (ZFA) ontology has led to surprisingly detailed insights into phenotypes. (ashg.org)
  • This chapter reviews the effects of exercise on the development of the musculoskeletal system, the cardiovascular system, metabolic capacities of developing zebrafish, and regulation of these processes on the gene expression level. (wur.nl)
  • Such restoration of ERK1/2 activation was sufficient to restore impaired arterial development and branching morphogenesis in synectin-deficient mice and synectin-knockdown zebrafish. (jci.org)
  • Thyroid hormones are required for skeletal development (Kim and Mohan, 2013), but to what extent thyroid hormone affects early bone development in zebrafish remained unclear. (wur.nl)
  • This provides the first histological evidence of increased ossification in zebrafish due to thyroid hormone exposure which can be used as a starting point to explore the mechanism of thyroid hormone on skeletal development at a greater depth. (wur.nl)
  • We used morpholino knockdown in zebrafish to define the role of mig6 in both exocrine pancreas and islet development. (diabetesjournals.org)
  • As a zebrafish embryo develops, the cells that will form its lateral line have to become pointed at one end and arrange themselves around a central, unchanged cell, like cloves in a bulb of garlic, forming a rosette. (innovations-report.com)
  • Utilising the proprietary phenotype-based zebrafish model for Dravet Syndrome, drug candidates were identified from a screen of more than 3,000 drugs that suppress seizures and symptoms associated with neurological diseases. (thefreedictionary.com)
  • Paired-end reads were collected on an Illumina 3000HT, then aligned to the most recent zebrafish reference genome (GRCz10). (springer.com)
  • The zebrafish reference genome sequence and its relationship to the human genome. (genome.jp)
  • [2] To facilitate use of the zebrafish as a model of human biology, ZFIN links these data to corresponding information about other model organisms (e.g., mouse ) and to human disease databases. (wikipedia.org)
  • Zebrafish Resources can be found at the central website of the zebrafish community at ZFIN . (tu-braunschweig.de)
  • Standard toxicity experiments carried out in typical cell culture experiments lack the complexity found in small model organisms such as zebrafish. (genengnews.com)
  • Traditionally, vertebrate model organisms such as mouse and zebrafish have been used on a gene-by-gene basis, however, in order to keep pace with the increasing speed of discovery, new approaches are needed. (ashg.org)
  • Regulation of tubulin and globin gene expression in zebrafish and Antarctic fishes. (elsevier.com)
  • We extensively analyzed palatogenesis in zebrafish to determine the similarity of gene expression and function across vertebrates. (nih.gov)
  • Zebrafish were also among the first vertebrates to be cloned (frogs were cloned decades earlier). (timesofmalta.com)
  • Burckle C, Gaude HM, Vesque C, Silbermann F, Salomon R, Jeanpierre C, Antignac C, Saunier S, Schneider-Maunoury S (2011) Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros. (springer.com)
  • Role of microtubules in morphogenesis of the zebrafish embryo. (elsevier.com)
  • Ensemble's Zebrafish Genome Browser is a central genome database, which offers information free online. (otago.ac.nz)
  • Pain, sedation, tumor metastasis, vascular tone, and gut motility are all examples of disease-relevant phenotypes that are observable in zebrafish yet inaccessible by modeling in cultured cells. (genengnews.com)
  • Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish," Mayssa H. Mokalled, Chinmoy Patra, Amy L. Dickson, Toyokazu Endo, Didier Y. R. Stainier, Kenneth D. Poss. (wingsforlife.com)