The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Transference of an organ between individuals of the same species or between individuals of different species.
A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
The measurement of an organ in volume, mass, or heaviness.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
The spiral EPITHELIUM containing sensory AUDITORY HAIR CELLS and supporting cells in the cochlea. Organ of Corti, situated on the BASILAR MEMBRANE and overlaid by a gelatinous TECTORIAL MEMBRANE, converts sound-induced mechanical waves to neural impulses to the brain.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An accessory chemoreceptor organ that is separated from the main OLFACTORY MUCOSA. It is situated at the base of nasal septum close to the VOMER and NASAL BONES. It forwards chemical signals (such as PHEROMONES) to the CENTRAL NERVOUS SYSTEM, thus influencing reproductive and social behavior. In humans, most of its structures except the vomeronasal duct undergo regression after birth.
A structure, situated close to the intraventricular foramen, which induces DRINKING BEHAVIOR after stimulation with ANGIOTENSIN II.
Abnormal descent of a pelvic organ resulting in the protrusion of the organ beyond its normal anatomical confines. Symptoms often include vaginal discomfort, DYSPAREUNIA; URINARY STRESS INCONTINENCE; and FECAL INCONTINENCE.
Elements of limited time intervals, contributing to particular results or situations.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
The relationships of groups of organisms as reflected by their genetic makeup.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Epithelial cells surrounding the dental papilla and differentiated into three layers: the inner enamel epithelium, consisting of ameloblasts which eventually form the enamel, and the enamel pulp and external enamel epithelium, both of which atrophy and disappear before and upon eruption of the tooth, respectively.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
An encapsulated lymphatic organ through which venous blood filters.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Organs and other anatomical structures of non-human vertebrate and invertebrate animals.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Ependymal derivative located at the junction of the THIRD VENTRICLE and the CEREBRAL AQUEDUCT; and the SOMATOSTATIN SECRETING CELLS.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Organs which might be damaged during exposure to a toxin or to some form of therapy. It most frequently refers to healthy organs located in the radiation field during radiation therapy.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
An institutional policy of granting authority to health personnel to perform procedures on patients or to remove organs from cadavers for transplantation unless an objection is registered by family members or by the patient prior to death. This also includes emergency care of minors without prior parental consent.
Formation of differentiated cells and complicated tissue organization to provide specialized functions.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
Established cell cultures that have the potential to propagate indefinitely.
Artificial organs that are composites of biomaterials and cells. The biomaterial can act as a membrane (container) as in BIOARTIFICIAL LIVER or a scaffold as in bioartificial skin.
Any of the large interior organs in any one of the three great cavities of the body, especially in the abdomen.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
The functional hereditary units of PLANTS.
The rate dynamics in chemical or physical systems.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Time period from 1901 through 2000 of the common era.
Genotypic differences observed among individuals in a population.
The transference of a part of or an entire liver from one human or animal to another.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
The period of history from the year 500 through 1450 of the common era.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The male reproductive organs. They are divided into the external organs (PENIS; SCROTUM;and URETHRA) and the internal organs (TESTIS; EPIDIDYMIS; VAS DEFERENS; SEMINAL VESICLES; EJACULATORY DUCTS; PROSTATE; and BULBOURETHRAL GLANDS).
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.
The transference of a kidney from one human or animal to another.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Time period from 1601 through 1700 of the common era.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)
A dead body, usually a human body.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Time period from 1501 through 1600 of the common era.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Proteins prepared by recombinant DNA technology.
Antibodies produced by a single clone of cells.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.
Refers to animals in the period of time just after birth.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
The transference of a heart from one human or animal to another.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.
An infant during the first month after birth.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
The parts of plants, including SEEDS.
Proteins found in any species of bacterium.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Time period from 1801 through 1900 of the common era.
Time period from 1401 through 1500 of the common era.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
The giving of drugs, chemicals, or other substances by mouth.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
The hollow, muscular organ that maintains the circulation of the blood.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Computer-based representation of physical systems and phenomena such as chemical processes.
A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
Downward displacement of the UTERUS. It is classified in various degrees: in the first degree the UTERINE CERVIX is within the vaginal orifice; in the second degree the cervix is outside the orifice; in the third degree the entire uterus is outside the orifice.
Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
Measurement of radioactivity in the entire human body.
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.
The total process by which organisms produce offspring. (Stedman, 25th ed)
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
A species of fruit fly much used in genetics because of the large size of its chromosomes.
Prospective patient listings for appointments or treatments.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
The period of history before 500 of the common era.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Disease having a short and relatively severe course.
The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.
Any method used for determining the location of and relative distances between genes on a chromosome.
A cell line derived from cultured tumor cells.
The systematic study of the complete DNA sequences (GENOME) of organisms.
Transport proteins that carry specific substances in the blood or across cell membranes.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
Notable organ scholars[edit]. *Heathcote Dicken Statham (1908-1911). Burials[edit]. *John Caius ... List of organ scholars. References[edit]. *^ a b "College History - Caius College Cambridge". Gonville & Caius College. ... Notable members[edit]. Nobel Prize laureates[edit]. *1932 Charles Scott Sherrington - neurophysiologist (student and fellow). ... Notable fellows and masters[edit]. See also List of Masters of Gonville and Caius College, Cambridge and Category:Fellows of ...
Cecilia is depicted in the window above the pipe organ. The 3-manual, 2900-pipe organ was installed by Tellers-Kent in 1921. At ... CS1 maint: discouraged parameter (link) "Sanctuary Windows Notable". Idaho Statesman. Boise, Idaho. May 29, 1921. p. 2. "Fine ... Cathedral Organ". Idaho Statesman. Boise, Idaho. May 29, 1921. p. 3. Cathedral Website Diocese of Boise Website. ...
Notable presidents in the second half of the twentieth century were David Tribe and Barbara Smoker, who did much to increase ... organ donation; and equality issues. It co-sponsored the launch of the Council of Ex-Muslims of Britain and a conference for ... Most notable have been interventions at the Council of Europe and the European Parliament. At a Council of Europe conference in ...
The church has a pipe organ by Rushworth and Dreaper dating from 1922. A specification of the organ can be found on the ... A notable achievement". Birmingham Daily Post. Birmingham. 24 July 1917. Retrieved 2 March 2015. "NPOR D02633". National Pipe ... Organ Register. British Institute of Organ Studies. Retrieved 2 March 2015.. ... National Pipe Organ Register. The Buildings of England. Warwickshire, Nikolaus Pevsner. p.165 "Foundation Stone Laying. ...
Pancreas an abdominal organ with multiple functions. It is a ducted organ which produces chemicals used in the intestines for ... The most notable of these latter is insulin. Pancreas transplant A surgical procedure that involves replacing the pancreas of a ... Kidneys organs which produce urine by excreting blood plasma and then resorbing important chemicals. Glucose and proteins are ... In another, there is a wider reaction, involving the blood or other organs. This is called a systemic allergy. The result can ...
2 Organ by Nicholson & Co Ltd of Worcester, 1878. Later organs (electronic), 1975, 1988, by Makin Organs Notable people in ... Architect: Troyte Griffith Organ: Nicholson & Co Ltd. Bells: One, in a small turret. Notable people in cemetery: Parish:Malvern ... 1354 Organ: 1882 by William Hill & Sons, London. Refurbished 2018-19 by Nicholson & Co Ltd Windows: Stained glass, 1480 Notable ... Architecture: Bells: Organ: 1841 by John Nicholson. Refurbished/restored 1974, 1981, 2017 Notable people in cemetery: Edward ...
Spreckels Organ Pavilion in San Diego's Balboa Park, housing the largest outdoor pipe organ in the world, was also built by ... CS1 maint: discouraged parameter (link) Press Reference Library (Southwest Edition): Notables of the Southwest. Los Angeles ... "The Spreckels Organ Pavilion in Balboa Park". San Diego Historical Society. Archived from the original on December 31, 2007. ... Furthermore, John commissioned Spreckels Organ in the Palace of the Legion of Honor in tribute to Adolph, who died before it ...
Notable attendees during Dr. Codman´s ministry tenure included John Adams and Daniel Webster. Paul Revere & Sons cast the bell ... The church also houses a pipe organ. The church was originally Congregational but became a Church of the Nazarene in 1991. ...
Istorijski glasnik: organ Društva istoričara SR Srbije. Društvo. 1969. p. 136. М. Пантић је показао да је текстове на ... Mavro Orbini (1563-1614) was a Ragusan chronicler, notable for his work The Realm of the Slavs (1601) which influenced Slavic ... Zarcalo dvhovno... (Spiritual Mirror...), 1606 (published later in 1621 in Venice and in 1703) List of notable Ragusans ...
Red Organ Serpent Sound (2008) ??? - Therapy? (2008) ??? - The Walls (2008) Below is a list of notable singles released by ... The show was notable for being amongst the victims of heavy weather that hit Ireland that weekend which also saw a number of ... Below is a list of notable albums & EPs released by Irish artists in Ireland in 2008. This list of songs or music-related items ...
Barry Waterlow performed two Radio Canada radio broadcasts of Poirier's organ music on the historic Louis Mitchell organ of ... His notable pupils included Eugène Lapierre and Alfred Tardif. Pourier was organist at a number of churches in Montreal, ... His pipe organ study began when he was 13. He studied at the francophone University of St. Joseph's College, Memramcook, New ... He created a number of compositions for organ and piano. Poirier was born Benjamin Perry in Tignish, Prince Edward Island. ...
He was also active as an organ teacher. Among his notable students were Christoph Albrecht, Karl Richter, Hanns-Martin Schneidt ... Notable among them is his much admired (although severely abridged) 1941 version of Bach's St Matthew Passion, including as ... He was the organist at the 1936 Nuremberg rally, playing on a specially constructed organ, the largest in Germany at the time. ...
The original pipe organ was mounted in the tower of the 1480 church. It was replaced by the present organ that is located to ... Notable monuments are 31 Commonwealth war grave memorials Alfred Wilcox VC (north of the church) The Ansell family vault, ( ... Notable Monuments The church has many high quality monuments dating from 1360 to 2018. These include 3 chest tombs ... The memorial was manufactured by Jones and Willis a notable Aston firm specialising in church furnishings. There are some ...
The Organ is from the studio of Montesanti. A canvas in the apse depicting the Madonna in Glory between St Dominic and Pius V ... The interior has notable artworks. In the altar belonging to the Gonzaga family is an Ecce Homo (1575) painted by Bernardino ...
Organ: Aivars Kalejs in Riga Cathedral - Release December 17. 2008 "LA GALANTE THE SOUL OF RIGA" (2 CD's) Inessa Galante. Organ ... She is described as one of the most notable followers of the legendary singer. Her concerts are recorded by Classic FM and BBC ... Mendelssohn, Three motets for female voice and organ. Woman's Folk Сhorus "Amber" (Sieviešu tautas koris "Dzintars") Conductor ... organ), Dita Krenberga (flute), cond. Kaspars Putniņš - 1997 "La Traviata" - Verdi. (2 CD's Live recorded. Latvian National ...
His most notable symphonic composition was The Tide. Ole Windingstad was born in Sandefjord, Norway. At age 14, he studied at ... the Music Conservatory in Oslo, Norway and three years later in Leipzig Germany . There he studied piano, organ, composition ... After a notable performance The New York Times reported on March 26, 1916: Under the auspices of the American-Scandinavian ...
Since 1991 the organ has been in the care of David Wells of Liverpool. See Gallery below Chester suffered badly at the hands of ... Notable organists include the composers Robert White and John Sanders, conductor George Guest and the recording artist Roger ... The organ was rebuilt and enlarged by Whiteley Bros of Chester in 1876, to include harmonic flutes and reeds by Cavaillé-Coll. ... There are lunchtime organ recitals weekly on Thursday. The monthly program of music is available on the cathedral's website. ...
In the electronic organ era, Gulbransen pioneered several innovations in the production of home electronic organs that became ... In the history of musical instruments, Gulbransen is notable for several innovations. In its early years, Gulbransen made the ... "The Gulbransen Organ". May 2006. Includes 1957 brochures of "Gulbransen Model B organ". "Rare Early Seeburg ... Electronic organ Drum machine Seeburg Corporation James Grebe (2011). "The Gulbransen Piano Company". Yesterday Once More ...
The organ also shipped with a volume pedal and offered three settings--organ, organ with bass keys and single-finger chords. ... Notable users include Nick Power of The Coral and Teenage Fanclub's Norman Blake. The Philicorda also features on 19 by Adele. ... The Philicorda was an electronic organ first produced in the 1960s by Philips. It was Philips' first entry into musical ... Chris Montez's 1962 Top 5 hit single "Let's Dance" features the Philicorda.. In recent years, the organ has undergone a revival ...
The organ was made by Frobenius' organ manufactury and has been located in the church since 1970. Its old organ is now located ... Notable burials include painter Mads Henriksen (1853-1940) and film director and producer Finn Henriksen (1933-2008). Lundtofte ...
Apart from singing, Murphy played piano and church organ. Following graduation, he moved to London to pursue a singing career ... During the series, Murphy sang with notable performers, including Italian opera singer Benamino Gigli and Robert Helpmann. In ...
In 1447, the organ at Ripon Cathedral was played by a priest, Thomas Litster. Notable organists have included composers Charles ... A specification of the organ can be found on the National Pipe Organ Register. The organ last underwent a major refurbishment ... The cathedral is notable architecturally for its gothic west front in the Early English style, considered one of the best of ... The cathedral has a fine organ by Harrison and Harrison, which is a rebuild of the original Lewis instrument dating from 1878. ...
The band's most notable performance, with Phil Ryan instead of Eric Burdon on lead vocals, was a 1992 performance in Moscow's ... Described as "Swirling organ and brass orchestrations with subtle pop psych elements. The sweeping album opener 'The Man Who ... Another notable standout is 'Heavy Load', which employs a catchy emotive chorus and more infectious orchestration moves. 'The ... Music Shop' and 'Landscape' have excellent organ work. 'Eight Is The Colour' works an aggressive brass arrangement...". ...
Choir Stalls Notable for the finely carved foliage and figures of kneeling angels. Reredos This was given by the Revd. W. H. ... Organ A two-manual instrument by Vowles of Bristol. Built in 1873, it now has electro-pneumatic action with 21 speaking stops. ...
A new 3 manual Lammermuir pipe organ was installed. The rebuilt sanctuary has notable, modern stained glass windows. Past ... Stained Glass, Sherbrooke St Gilbert's Church (archived version, 2004) Church ...
Notable residents[edit]. Up to 1700[edit]. *James Bell (1524-1584), Catholic priest and martyr,[53] born in Warrington. ... Thomas Dallam (c1570 - 1614), Organ builder [54] and Elizabethan trade envoy to Constantinople. His family came from Dallam ... Gareth Jones (born 1954 in Warrington) British music producer and engineer notable for working with Depeche Mode ... Parr Hall, home to one of the few remaining Cavaillé-Coll organs. ...
... he wrote an extended solo for organ with Haven in mind. As released, the jazz adaptation marks a notable departure from the ... They were 'Organ Show', 'Images' and 'Collector's Item'. Local musicians, including Eric Delaney, organised a big band night ... His early work was performed on a Lowrey organ. When Barry decided to adapt his own Oscar-winning theme from the 1968 medieval ...
Principles of General Surgery Liver Transplant Kidney Transplant Ethics of Organ Transplants Ehtuish's most notable positions ... Ehtuish developed Organ transplant in 2003 when he established the National Transplant Program and served as Director from 2003 ... He has performed over 650 organ transplants. The program has a high rate of success with 95% of those receiving transplants ... Billiary Surgery and organ transplant in Libya. Ehtuish served as The Director of Tripoli Central Hospital then chairman of the ...
Barth was a notable music theorist and was one of the first independent writers in this field in his region. His works were ... Barth played violin, horn, cello and organ. He was appointed to the Royal Life Guards from 1834 to 1838. In 1852, Barth was the ...
There is notable decreased expression of c14orf119 in the following tissues, pancreas, bone marrow, brain, salivary glands, and ... C14orf119 is expressed in 203 organs. The c14orf119 gene is expressed in a number of tissues and has the highest expression ... Additionally, there is notable increased expression of c14orf119 in the adrenal gland, kidney, lung, prostate, thymus, white ...
Notable people with type 1 diabetes. Retrieved from " ...
Furthermore, most tissues (with the notable exception of liver and kidneys) cannot remove the phosphate added by hexokinase. ... This is very useful in showing detailed views of moving organs or structures with higher anatomical variation, which is more ... Brain images obtained with an ordinary (non-PET) nuclear scanner demonstrated the concentration of FDG in that organ. Later, ...
According to current archaeological and genetic models, there were at least two notable expansion events subsequent to peopling ... plant underground storage organs) may have been eaten in high amounts by pre-agricultural humans.[109][110][111][112] It is ... Paleolithic humans consumed animal organ meats, including the livers, kidneys, and brains. Upper Paleolithic cultures appear to ... "Savanna chimpanzees use tools to harvest the underground storage organs of plants" (PDF). Proc Natl Acad Sci U S A. 104 (49): ...
World Health Organ. 91 (4): 277-282. doi:10.2471/BLT.12.110015. PMC 3629451. PMID 23599551.. ... Notable Islamic medical pioneers include the Persian polymath, Avicenna, who, along with Imhotep and Hippocrates, has also been ... From Germany and Austria, doctors Rudolf Virchow, Wilhelm Conrad Röntgen, Karl Landsteiner and Otto Loewi made notable ... These include trauma centers, burn treatment centers, advanced neonatology unit services, organ transplants, high-risk ...
Notable historic Lenape people[edit]. This includes only Lenape documented in history. Contemporary notable Lenape people are ... and use compound containing root bark as a tonic for the female generative organs. [36] ... root bark of Viburnum prunifolium with leaves of other plants of other plants and use it to strengthen female generative organs ...
A tenor soloist appears as Saint Nicolas, with a mixed choir, boys singers, strings, piano duet, organ and percussion.[114] ... who knew all the notable bishops of the period,[52] nor is he mentioned by the historian Eusebius, who was also present at the ... percussion and organ". Britten-Pears Foundation. 1948. Archived from the original on 4 March 2016. Retrieved 5 December 2018.. ...
A notable reagent is Schlosser's base, a mixture of n-butyllithium and potassium tert-butoxide. This reagent reacts with ... organ changes and tissue accumulation". Journal of Environmental Science and Health, Part A. 16 (5): 549-567. doi:10.1080/ ...
In organ transplantion[edit]. A1::DQ2 was at the forefront of histocompatibility science, A1 was the first numerical antigen HL ... Two recombinants A24-Cw7~DQ2, A1::B8-DR1-DQ5 are notable. Thus, A1::DQ2 haplotype is both long and shows greater deficiency of ...
List of notable brain tumor patients. *Pituitary adenomas ("pituitary tumours") are sometimes incorrectly referred to as a ... Secondary tumors of the brain are metastatic and have invaded the brain from cancers originating in other organs. This means ... However, they create specific issues that follow closely to the properties of the organ they are in.[26] ... Primary brain tumors rarely metastasize to other organs; some forms of primary brain tumors can metastasize but will not spread ...
Notable publications[edit]. *1810: Indice d'ittiologia siciliana ossia catalogo metodico dei nomi latini, italiani, e siciliani ... Deviations in essential organs may thus gradually become new genera.[33]. In the third edition of On the Origin of Species ... All sites in Kentucky that were included by E. G. Squier and Davis in their notable Ancient Monuments of the Mississippi Valley ... Rafinesque made a notable contribution to North American prehistory with his studies of ancient earthworks of the Adena and ...
The rebuilding was performed by Mander Organs[18] and it is now the second largest pipe organ in the British Isles with 9,997 ... Other notable films shot at the Hall include Major Barbara, Love Story, The Seventh Veil, The Ipcress File, A Touch of Class, ... "The Grand Organ, Royal Albert Hall". Mander Organs. Retrieved 17 June 2011.. ... One notable event was a Pink Floyd concert held 26 June 1969, the night they were banned from ever playing at the Hall again ...
Notable guest stars over the years included Louis Gossett Jr., Sterling Holloway, Virginia Mayo, Chips Rafferty and Paul ... According to the record liner notes, Manne and fellow percussionists play ankle and wrist jingles, Thai mouth organs, angklungs ...
Famous and notable contributors[edit]. Over the centuries, many important scientific discoveries have been published in the ... In fact, the first English newspaper, The London Gazette (which was an official organ of government and therefore seen as ... By the mid-eighteenth century, the most notable editors, besides Oldenburg, were Hans Sloane, James Jurin and Cromwell Mortimer ... many readers saw the journal as an official organ of the Society.[1] It has been argued that Oldenburg benefitted from this ...
Notable libertarian Marxist tendencies[edit]. First English edition of Lenin's "Left-Wing" Communism: An Infantile Disorder, ... It was to take advantage of the aura of workplace power that the word became used by Lenin for various political organs. Indeed ... Notable theorists of libertarian Marxism have included Anton Pannekoek, Raya Dunayevskaya, CLR James, E. P. Thompson, Rosa ...
... exhibited notable sexual dimorphism with males markedly bigger than females. However, relative female body mass is unknown in ... relied primarily on underground storage organs (such as tubers) and food sharing, which facilitated social bonding among both ...
There is a notable decline in the total number of phagocytes in aged hosts, coupled with an intrinsic reduction of their ... After birth, the decline of T-cell function begins with the progressive involution of the thymus, which is the organ essential ...
... notable footballers are Didier Drogba, Yaya Touré and Kolo Touré, Eric Bailly, Gervinho, Nicolas Pépé, and Wilfried ...
Other notable writers from Antiquity through to the Renaissance include Aristotle, Xenophon, Chanakya (also known as Kautilya ... organ donations, unhealthy foods, mortgage deductions, taxing internet sales, Wal-Mart, casinos, ethanol subsidies, and ...
Notable awards and positions[edit]. 1950-51, Fulbright scholarship, The Zoological Station, Naples, Italy ... Bullock discovered the pit organ in pit vipers and electroreceptors in weakly electric fish, as well as other electrosensory ...
... s do not have vocal cords, so sound is accomplished by expelling air across the mouth of the trachea in the organ called ... with some notable exceptions, the most striking being the eclectus parrot.[21]:202-207 However it has been shown that some ... Touch receptors occur along the inner edges of the keratinised bill, which are collectively known as the "bill tip organ", ... Seed-eating parrots have a strong tongue (containing similar touch receptors to those in the bill tip organ), which helps to ...
Mutations in maize promoters affect the expression of the promoter genes in a plant-organ-specific manner.[29] A duplication of ... there are others that have detected notable differences between archaeal and eukaryotic TBP. The archaea protein exhibits a ... "The TATA box promoter region of maize Adh1 affects its organ-specific expression". The EMBO Journal. 11 (1): 157-66. doi ...
"The Organ Donor's March". They raised $17,000 USD on Kickstarter from over 400 backers in April 2011.[54] ... Notable work. Shell Game (2013), Week in Hell (2012), Drawing Blood (2015), Brothers of the Gun (2018). ...
... then organs and ultimately systems.[12] The G phases along with the S phase - DNA replication, damage and repair - are ... Notable cell biologistsEdit. *Jean Baptiste Carnoy. *Peter Agre. *Günter Blobel. *Robert Brown ...
Their research argues that sexual organs bathe the embryo with hormones in the womb, resulting in the birth of an individual ... notable especially for its call to empower femininity:[131][132] .mw-parser-output .templatequote{overflow:hidden;margin:1em 0; ...
Two of its most famous sons are the authors Laurie Lee, whose most notable creation Cider with Rosie is set in the nearby Slad ... A reference to a 1798 Poem mocking Stroud residents for opening a church organ "before it could speak".[14] "Gotham" was a ... Notable peopleEdit. ActivistsEdit. *Polly Higgins, barrister, author, and environmental lobbyist lived near Stroud for the last ...
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism ... Notable people. *Edna B. Foa. *Stanley Rachman. *Adam S. Radomsky. *Jeffrey M. Schwartz ...
Heinonen I, Kalliokoski KK, Hannukainen JC, Duncker DJ, Nuutila P, Knuuti J (November 2014). "Organ-specific physiological ... Notable people. *Edna B. Foa. *Stanley Rachman. *Adam S. Radomsky. *Jeffrey M. Schwartz ...
... north organ chamber, and vestry. It is built of red brick with slate roofs.[4] ... Places listed are articles notable as settlements, arranged by post town. Retrieved from " ...
Stuart Organ, Actor. *Colonel Mike Osborn DSO OBE MC, British military officer and former commander of the 22nd Special Air ... Notable Old Cranbrookians[edit]. See also: Category:People educated at Cranbrook School, Kent ...
"Notable Signers". Humanism and Its Aspirations. American Humanist Association. Archived from the original on October 5, 2012. ... the Golgi tendon organ and the Golgi tendon reflex. He is recognized as the greatest neuroscientist and biologist of his time.[ ... I present here two examples of notable atheists. The first is Lev Landau, the most brilliant Soviet physicist of the twentieth ... Their atheism must be relevant to their notable activities or public life in order to be included on this list. ...
Notable organ scholars[edit]. *Heathcote Dicken Statham (1908-1911). Burials[edit]. *John Caius ... List of organ scholars. References[edit]. *^ a b "College History - Caius College Cambridge". Gonville & Caius College. ... Notable members[edit]. Nobel Prize laureates[edit]. *1932 Charles Scott Sherrington - neurophysiologist (student and fellow). ... Notable fellows and masters[edit]. See also List of Masters of Gonville and Caius College, Cambridge and Category:Fellows of ...
Notable cases. Paediatric lobar lung transplantation: addressing the paucity of donor organs. ...
List of notable pipe organs "Your Questions... Answered: How many pipes does the Midmer-Losh organ have?". Atlantic City ... In 2013, the organ once again began to be restored, with 15-20% of the organ operational. The organ was played in September ... The organ is built around the Main Auditorium of the Boardwalk Hall. The organs divisions are divided across 8 organ chambers ... The organs wind supply is the most powerful ever used in a pipe organ. The DC motors for the original eight blowers had a ...
This is a list of notable pipe organ builders. William Anderson (1832-1921) Australian Pipe Organs Pty Ltd Robert Cecil Clifton ... New York City Organ Supply Industries, Erie, Pennsylvania Page Organ Company, Lima, Ohio Parkey Organs, Atlanta, GA Pasi Organ ... Pipe Organ Database Abbott and Sieker Æolian Company (see also Æolian-Skinner Organ Company) Æolian-Skinner Organ Company (1932 ... Levsen Organ Company (from 1954) around Buffalo, Iowa Link Piano and Organ Company Los Angeles Art Organ Company, The M.P. ...
notable works. *"Study of Organ Inferiority and Its Psychical Compensation". subjects of study. *instinct ... Study of Organ Inferiority and Its Psychical Compensation), in which he suggested that persons try to compensate ...
... and to the building of more complex tissues and solid organs," Atala told Quartz. "When printing human tissues and organs, of ... New 3D printer said to produce organs, tissues, bones. Researchers found 3D-printed ears, muscle tissue, and part of a jawbone ... We will be using similar strategies to print solid organs." RELATED Cancer database goes 3D to help drug design ... "Future development of the integrated tissue-organ printer is being directed to the production of tissues for human applications ...
For the organ development annotation, the over-representation was insignificant (P , 0.074) but notable. The x axis represents ... 1996) Isolation, characterization and organ-specific expression of two novel human zinc finger genes related to the Drosophila ... Further classification of the developmental genes revealed over-representation of genes associated with organ development, ... GAHM-H3K27 and Sall4 also had notable roles in development (P , 0.07; Fig. 4B). This reveals a system in which regulation of ...
Notable residents[edit]. Up to 1700[edit]. *James Bell (1524-1584), Catholic priest and martyr,[53] born in Warrington. ... Thomas Dallam (c1570 - 1614), Organ builder [54] and Elizabethan trade envoy to Constantinople. His family came from Dallam ... Gareth Jones (born 1954 in Warrington) British music producer and engineer notable for working with Depeche Mode ... Parr Hall, home to one of the few remaining Cavaillé-Coll organs. ...
To best understand the organ procurement process, reviewing the history of transplantation is helpful. ... Organ procurement is intimately tied to the history of organ transplantation and organ donation. ... To best understand the organ procurement process, reviewing the history of transplantation is helpful. Notable events have ... The number of organs can range from only the kidneys to all organs, including the intestine. After these organs are deemed ...
Can Attack Organs, by Matt Richtel and 20,000 other business, leadership and nonfiction books on getAbstract. ... 6 - Notable. A helpful and/or enlightening book that stands out by at least one aspect, e.g. is particularly well structured. 7 ... Summary of Immune System, Unleashed by Cancer Therapies, Can Attack Organs Matt Richtel ...
According to data from the United Network for Organ Sharing (UNOS), more than 400,000 renal transplantations have been ... Notable problems are associated with this approach. For instance, the packing density of cells in an organ can approach 80%, ... Techniques of Organ Preservation. Because most transplanted organs are from deceased donors, the organ must inevitably be ... encoded search term (Organ Preservation) and Organ Preservation What to Read Next on Medscape. Related Conditions and Diseases ...
Cancer that begins in either organ is generally known as colorectal cancer. ... Notable Progress Against Colorectal Cancer Shown in 10-Year National Study. By Elizabeth Fernandez on June 01, 2014 ... Home > UCSF News Center > Notable Progress Against Colorectal Cancer Shown in 10-Year National Study ...
Forty eight DEGs were shared by both organs, with gene ontology (GO) annotations corresponding to transcription regulation, RNA ... Forty eight DEGs were shared by both organs, with gene ontology (GO) annotations corresponding to transcription regulation, RNA ... the set of genes that underlie the molecular mechanisms of genetic control of tissue and organ growth and body size, as ... the set of genes that underlie the molecular mechanisms of genetic control of tissue and organ growth and body size, as ...
Thus, organ-specific functions are not necessarily lost in cell cultures, but might be merely suppressed in FBS. The effect of ... Finally, organ-specific functions are restored, including xenobiotics degradation and secretion of bile, VLDL and albumin. ... The most notable changes involved Xenobiotics biodegradation and metabolism. Three pathways in this cluster were ... Thus, organ-specific functions are not necessarily lost in cell cultures, but might be merely suppressed in FBS. The effect of ...
The human body has a few organs and parts we no longer need. Charles Darwin pointed to these vestigial parts as evidence for ... Here are five of the most notable vestigial organs in humans:. The Appendix: This small pouch attached to your large intestine ... Eventually, by noting how the vestigial organs in one species were similar to functioning organs in other species, biologists ... We no longer rely on these organs or structures for any serious function, or they have atrophied or degenerated to the point ...
Notable equipment: Clean benches; Incubators; Fluorescence Microscopes; RT-PCR; Spectrophotometers.. Human Tissues and Organs ... Notable equipment: Peptide Synthesizer; Microspotter; HPLC. In vitro Tissue Production: the in vitro production of macroscopic ... Notable Equipment: AFM; dynamometer; solid state NMR; XPS; Gi-SAXS; FT-IR and Raman spectrometer; Ellipsometer; Tensiometer; CD ... Notable Equipment: STED and Multiphoton Confocal Microscopes; AFM; cryo-TEM; SEM; microCT scanner; Ultra High Pressure Freezer. ...
Tissues and Organs - 1st Edition. Print Book & E-Book. ISBN 9780128136652, 9780128136669 ... He also serves as editor or guest editor for several notable journals. Dr. Grumezescu has published 150 peer-reviewed papers, ... Nanostructures for the Engineering of Cells, Tissues and Organs 1st Edition. From Design to Applications. Write a review ... organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using ...
... and Other Organs), By End User (Hospitals, Organ Transplant Centers, Specialty Clinics, and Others), By Distribution Channel ( ... Other Notable Players 15. Conclusion. 16. Glossary. Associated Visiongain Reports. Visiongain Report Sales Order Form. Appendix ... 6.1.5. Other Organs. Other Organs market size and forecast, 2021-2031 (USD Million). 7. Global Organ Preservation ... Organ Preservation Solutions Market Forecast By Organ Type 2021-2031 (US$Mn, AGR %, CAGR %) (Before COVID). Table 78. Organ ...
Notable toxicities were cryptococcal. pneumonia (one patient); unexplained focal seizures 30 days after the. fourth ... pulmonary toxicity (one patient); and secondary organ failure of. uncertain etiology leading to death (one patient). ...
Most notable Euplokamis-specific features are the following: (a) Comb nerves with giant axons. These nerves directly coordinate ... Beroe; Ctenophora; F-actin; Mnemiopsis; Pleurobrachia; Stereocilia; apical organ; cell atlas; cilia; development; evolution; ... the rapid escape response bypassing the central integrative structure known as the aboral sensory organ. (b) Neural processes ...
Clive Callender and his colleagues sat down to took a look at African-American organ donation numbers, and they were grim. ... In 1982, nationally there were eight organ donors per million African-Americans. But by 2002, there were 41 organ donors per ... But I was well accustomed to adversity, to reaching for unreachable stars and impossible dreams. (Read more on notable black ... This was terrible news for African-Americans in need of an organ, who were much more likely to make a genetic match with ...
This article contains information about the Pipeorgan [Care and Maintenance of a Pipe organ:Craftsmanship in maintenance] ... There can be a notable change in the sound when cleaning is performed. ... Musical Instrument Guide : Pipe Organ Contents. Origins. *The birth of the pipe organ ... A clean organ produces the best sound. It is said that if the top of the soundboard is cleaned when a piano is tuned, its sound ...
There was a notable album in 1948 with a sister, singer Texas Gladden.) He worked as a farmer and a painter and a butcher. At ... Hed come up buck-dancing, learning to play the pump organ before he could reach the seat. Square-dance gigs gradually gave way ... organ, accordion. Still, the range of recordings is wide. Smith himself seemed downright perplexed that his recall of even the ...
3000 biographies of notable scientific figures MORE THAN 17,000 downloadable images and animations illustrating key topics ...
Not all of the organs in your body are essential. Some people can live quite happily without their spleen, colon or even ... When you look inside the spleen, it has two notable colours. A dark red colour and small pockets of white. These link to the ... Here are some of the "non-vital organs".. Spleen. This organ sits on the left side of the abdomen, towards the back under the ... Reproductive organs. The primary reproductive organs in the male and female are the testes and ovaries, respectively. These ...
However, there are notable differences between Crouzon syndrome and Apert syndrome. Most striking is the consistent finding of ... other organs and tissues including the brain are affected in craniosynostosis conditions. In addition to the premature closure ...
... efforts to grow kidneys have long been frustrated by the inability to create the vasculature necessary for a functional organ. ... Until now, scientists had not known that the kidney was a blood-generating organ. Blood generation occurs within the kidney in ... fish, but this is a notable discovery in mammals.. Obstacles to Growing Kidneys ... Researchers have long been able to grow kidney tissue in a lab dish, successfully forming various components of the organ. But ...
Newspapers have played an important historical role as the organs of revolutionary propaganda. The most notable of such ... Two rival political organs were Alexander Hamiltons Gazette of the United States and Thomas Jeffersons National Gazette, ... Serious reporting during Watergate was notable, as was the courage of the New York Times, the Washington Post, and the St. ... The most notable paper was the National Economist with more than 100,000 readers at its peak. However, more than one thousand ...
In the case of the spleen, there was also notable organ enlargement. The details of this have yet to be investigated. Next, ... Organs were harvested, and BrdU+ cells were detected with an horseradish peroxidase-labeled antibody and light microscopy. ... BrdU was administered for 100 minutes (thymus) or 24 hours (other organs). The proportion of BrdU+ cells per 2000 to 5000 total ... The most frequent pathology before the onset of malignancy was aggregates of nonmalignant lymphocytes in at least one organ. ...
The liver is an enormously important organ that has many functions. The most notable abnormalities that result from a shunt are ...
  • Organ procurement is intimately tied to the history of organ transplantation and organ donation. (
  • To best understand the organ procurement process, reviewing the history of transplantation is helpful. (
  • Organ procurement was started as a local endeavor when facilities performing kidney transplantation recovered organs from donors in the same facility. (
  • As the organization and the field of transplantation grew, organ sharing became a nationwide responsibility. (
  • In the early 1980s, the development of cyclosporine made the transplantation of all organs more feasible than before. (
  • According to data from the United Network for Organ Sharing (UNOS), more than 400,000 renal transplantations have been performed since the first successful renal transplantation in the 1950s. (
  • As a result, the list of indications for solid-organ transplantation has expanded considerably, placing increasing pressure on an already limited supply of donor organs. (
  • The removal, storage, and transplantation of a solid organ from a donor profoundly alters the homeostasis of the interior milieu of the organ. (
  • These effects manifest in the degree to which the return of normal organ function is delayed or prevented after transplantation is completed. (
  • The injury an organ sustains during recovery, preservation, and transplantation occurs primarily as a result of ischemia and hypothermia. (
  • Damage to organs during transplantation occurs in 2 phases. (
  • The second, the cold ischemic phase, occurs when the organ is preserved in a hypothermic state prior to transplantation into the recipient. (
  • Calling Callender a 'pioneer,' Joel Newman, a spokesman for the United Network for Organ Sharing, said Callender's work 'has helped identify and address many misconceptions the public has about organ donation and transplantation. (
  • xeno- from the Greek meaning foreign) is the transplantation of living cells, tissues or organs from one species to another such as from pigs to humans (see Medical grafting). (
  • Routine screening of organ donors for human immunodeficiency virus (HIV) infection has made transmission of HIV through organ transplantation rare in the United States. (
  • However, despite routine screening, transmission of HIV can be an uncommon complication of organ transplantation and is a public health concern. (
  • This report summarizes the results of the subsequent public health investigation, which confirmed HIV transmission through transplantation of an organ from a living donor. (
  • To reduce the risk for transmission of HIV through living-donor organ transplantation, transplant centers should screen living donors for HIV as close to the time of organ recovery and transplantation as possible, using sensitive tests for both chronic and acute infections, namely, serology and nucleic acid testing (NAT). (
  • In terms of regional platform, North America region captured the largest market of organ on a chip in terms of revenue owing to increasing utilization of organ on a chip in organ transplantation coupled with rising number of organ transplantation. (
  • Shortage of organs for transplantation - is more research on human-animal chimeras the right approach? (
  • There is currently a dire shortage of organs for transplantation in the United States, leading to approximately 22 deaths per day among patients waiting for organs. (
  • Whole organ transplantation: the first program in New England to establish a high rate of success and safety of simultaneous kidney/pancreas transplantation. (
  • It's a discovery of critical importance, as efforts to grow kidneys have long been frustrated by the inability to create the vasculature necessary for a functional organ. (
  • In bone marrow, even more so than for solid organs such as kidneys and livers, it's important to find a donor of the same ethnic group. (
  • Each year, there is a severe shortage of kidneys for organ transplant. (
  • Add your kidneys to the list of organs that may thank you for going gluten-free. (
  • When printing human tissues and organs, of course, we need to make sure the cells survive, and function is the final test. (
  • Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. (
  • The interactions range from individual biomolecules, cells up to tissues and organs and might occur in a broad range of timescales. (
  • Within this context, the research activities are organized according to specific platforms, namely Cell Instructive Materials, Tissues and Organs-on-Chip, Theranostic Nanoshuttles and Molecular Sensing Materials. (
  • micronscale mimics of organs and tissues are assembled in miniaturized fluidic devices in order recapitulate the systemic interactions between different tissues and organs. (
  • Systemic lupus erythematosus (also called lupus or SLE) is a disease in which a person's immune system attacks and injures the body's own organs and tissues. (
  • This however will result in the receiver of organs to take immunosuppressive drugs to prevent their body's antibodies causing transplant rejection , destroying the new organ. (
  • Many of the body's major organs rely on the rib cage to protect them from harm. (
  • You can even lose large chunks of vital organs and live. (
  • Free radical damage, oxidative stress and inflammation wreak havoc on these vital organs and tissues. (
  • But there are other seemingly vital organs that aren't all that vital at all. (
  • Although there have been some successful uses of 3D-printed body parts -- a cancer patient received ribs printed using titanium -- progress has been made on methods of printing whole organs , and scientists in England have created scaffolds that allow for the regrowth of bones . (
  • Such scaffolds may be produced through the decellularization of whole organs. (
  • Sometimes, a deceased-donor organ (specifically the liver) may be divided between two recipients, especially an adult and a child.But it is not usually preferred, because the transplantations of whole organs are more useful. (
  • As the need for organs increased and as the specialty expanded to include other solid organs (eg, heart, lung, liver, pancreas, small intestine), the need for improved sharing agreements and organ distribution was recognized. (
  • This article discusses the pathophysiology, techniques, and principles of organ preservation, and idescribes various preservation solutions currently used for kidney , liver , pancreas , small-bowel , lung , and heart transplantations. (
  • The liver is an enormously important organ that has many functions. (
  • A notable exception is the liver. (
  • These exceptions include issues related to the use of surrogate organs for calculation of organ doses from external sources, for example the use of the urinary bladder for the prostate gland and the use of the stomach for the liver, gall bladder, and spleen. (
  • The global organ on a chip market is segmented into organ such as heart-on-chip, human-on-chip, intestine-on-chip, kidney-on-chip, liver-on-chip and lung-on-chip. (
  • On the other hand, as vertebrates, ZF possess organs and tissues, such as heart, kidney, liver, pancreas, intestinal tract, and brain that display analogous structures and functions to those found in humans [ 7 ]. (
  • spleen, liver, lymph nodes) and to end organs. (
  • With success in these early sharing agreements, SEROPP was awarded a contract to develop an organ procurement and sharing network among 9 medical centers in a 4-state area extending from Baltimore, Maryland, to Atlanta, Georgia. (
  • The country was divided into 9 geographic regions designed to include previous organ sharing patterns among transplant centers. (
  • [ 1 ] With such constraints, preservation of organs for transport between centers becomes crucial. (
  • When you look inside the spleen, it has two notable colours. (
  • Two of the most notable organs behind the left side of the rib cage are the left lung and the spleen. (
  • The spleen is an internal organ that can be found beneath the ribs on the left side of the abdomen. (
  • The primary reproductive organs in the male and female are the testes and ovaries, respectively. (
  • Pelvic inflammatory disease (PID) is an infection of your reproductive organs. (
  • 1983: The US Food and Drug Administration (FDA) approved the use of cyclosporine in solid-organ transplantations. (
  • Most solid-organ transplantations are now performed as the therapeutic option of choice. (
  • Unlike other vertebrates, adult mammals have limited organ regeneration capabilities. (
  • Cephalopods such as octopus have complex chromatophore organs controlled by muscles to achieve this, while vertebrates such as chameleons generate a similar effect by cell signaling . (
  • ATG has been used predominately in solid organ transplant immunosuppressive regimens. (
  • The pancreas is a retroperitoneal organ that serves two functions: exocrine - it produces pancreatic juice containing digestive enzymes endocrine - it produces several important hormones Anatomy The pancreas is a retroperitoneal organ located posterior to the stomach on the posterior abdominal wall. (
  • Your pancreas is an organ. (
  • Among these segments, lung-on-chip segment captured the largest market in overall organ on a chip market in 2016 and it is expected to continue its dominance during the forecast period. (
  • Although ZF have been shown to be a beneficial complementary model to rodent in many research fields, they lack some of the typical mammalian organs such as lung, prostate, skin, and mammary glands. (
  • However, vascular leakage was significantly increased in multiple organs, and after subjection to normobaric hypoxia (8% O 2 ), Cd73 −/− mice manifested fulminant vascular leakage, particularly prevalent in the lung. (
  • Sarcoidosis is a disease believed to be due to immune cells, cells which normally protect the body, but are now attacking lungs, heart, nerves, or other organs or systems within the body. (
  • Dr. Cheng said this is notable because massive inflammation in the lungs and potentially other organs may be fatal in the illness. (
  • While blacks represented about 12 percent of the U.S. population, they represented only about 3 percent of organ donors. (
  • Some blacks worried that by becoming organ donors they might unwillingly become a part of another medical experiment, or that white doctors would prematurely declare them dead in order to harvest their organs. (
  • In 1982, nationally there were eight organ donors per million African-Americans. (
  • But by 2002, there were 41 organ donors per million African-Americans, according to the National Minority Organ Tissue Transplant Education Program. (
  • But this dramatic increase in African-American organ donors has not happened for bone marrow, where there's a different system for obtaining donors. (
  • Organ donors can be living or deceased (previously referred to as cadaveric). (
  • Furthermore, clinicians should inform transplant candidates of the potential risks for disease transmission and advise donors during evaluation of their obligation to avoid behaviors that would put them at risk for acquiring HIV before organ donation. (
  • The first, the warm ischemic phase, includes the time from the interruption of circulation to the donor organ to the time the organ is flushed with hypothermic preservation solution. (
  • According to the statistics suggested by the National Kidney Foundation, 2016 around 121,678 people were waiting for lifesaving organ transplants in the in the United States. (
  • It is also reported that in 2014, 17,107 kidney transplants took place in the U.S. The incidences of organ failure are found to be more common in the aging population, as it is more vulnerable towards health issues such as ophthalmic diseases, gastrointestinal problems, orthopedic diseases, cancer, and others. (
  • Most human tissue and organ transplants are allografts. (
  • CNN) -- In 1982, transplant surgeon Dr. Clive Callender and his colleagues sat down to took a look at African-American organ donation numbers, and they were grim. (
  • Instead, they went into African-American communities in their city to find out why the organ donation rates were so low. (
  • Dr. Clive Callender has worked for decades to change African-American attitudes about organ and marrow donation. (
  • Organ donation is the removal of specific tissues of the human body from a person who has recently died, or from a living donor, for the purpose of transplanting them into other persons. (
  • What he fails to examine is whether the creation of humanised animal models is the best way to address this pressing matter, and he fails to acknowledge the existence of viable alternatives, such as opt-out policies to increase organ donation from human to human. (
  • If the box is not checked on the license, the organs are donated to the 50,000 people dying each year waiting for organ donation. (
  • The Supremacy has proposed such presumptive donation, and the use of the Kelo decision to take organs when suitable. (
  • As of 2002, notable progress has been made in narrowing the location of these genes. (
  • present) - Istanbul Balfour-Rowley Ltd. Organ Builders (2016-present) - Worksop Bishop & Sons (1795-present ) - London and Ipswich W & A Boggis (1932-present) - Roydon, South Norfolk F. Booth & Son Ltd. (1951-present) - Stanningley, West Yorkshire Bower & Company (1972-present) - Wroxham, Norfolk F. H. Browne & Sons (1870-present) - Canterbury, Kent. (
  • 1972: The Uniform Anatomical Gift Act established the Uniform Organ Donor Card as a legal document in all 50 states, making it possible for all persons aged 18 years or older to legally donate their organs. (
  • In a fashion not totally unlike that of pipe organs, reed organs generate sound by forcing air over a set of reeds by means of a bellows, usually operated by constantly pumping a set of pedals. (
  • It signals organs to generate a response essential for survival. (
  • BUD - organ or shoot containing an embryonic branch, leaf or flower. (
  • Construction of the organ took place between May 1929 and December 1932. (
  • Plant organogenesis is a postembryonic event, and the aboveground organs typically originate at the periphery of the shoot apical meristem, located at the apex of the main shoot ( 2 ). (
  • Inspiration for the tonal design can be found in small French "Choir Organs" that were typically found in the chancel of cathedrals, separate from the main organ and designed primarily for accompanimental purposes. (
  • Cancer that begins in either organ is generally known as colorectal cancer. (
  • This selection is determined largely by the cancer diagnosis and is fairly straightforward for solid tumors, with a few notable exceptions. (
  • The calculation of the probability that a claimant's cancer was caused by occupational exposure to radiation is based on the relevant organ dose and type of cancer, and this calculation informs the compensation decision made by the Department of Labor. (
  • These attributes further extended the use of ZF to include the fields of metabolic organ diseases, including cancer [ 4 , 12 - 14 ]. (
  • His most notable contributions concern the link between advancing age and increasing risk of cancer. (
  • The Integrated Tissue and Organ Printing System, developed during the last decade at Wake Forest's Institute for Regenerative Medicine, uses plastic-like materials to shape the tissues and water-based gels to deliver living cells to the tissues, according to a press release. (
  • But by identifying the stem cells that develop into the vessels, UVA's Maria Luisa S. Sequeira-Lopez, MD, and her team have given scientists a target to manipulate so that one day they may be able to grow complete organs. (
  • Ideally, the resulting extracellular matrices would retain the organ-specific architecture and chemical composition to guide implanted cells into functional structures and eventually working organs. (
  • Examining the ability of these cells to proliferate and differentiate in a whole kidney extracellular matrix scaffold would serve as a valuable baseline for future studies in producing a functioning organ. (
  • When these white blood cells infiltrate certain tissues, the result could be inflammation and organ damage. (
  • An electric organ , also known as electronic organ , is an electronic keyboard instrument which was derived from the harmonium , pipe organ and theatre organ . (
  • The immediate predecessor of the electronic organ was the harmonium , or reed organ , an instrument that was very popular in homes and small churches in the late 19th and early 20th centuries. (
  • The company produces organ-models, living 3D cell cultures and scaffolds. (
  • And inflammation starts in the cell, spreading to tissues, organs and entire systems. (
  • Since it has been demonstrated that TNBS-induced acute colitis results in endoxemia and neural inflammation, due to a breakdown of the intestinal barrier and increased permeability of the colon ( 6 - 9 ), the contribution of ECS to organ-protection in TNBS-induced colitis was investigated in the study. (
  • Macrophage entry into tissues is notable in areas of active HIV-1 replication and sites of inflammation. (
  • Eventually, by noting how the vestigial organs in one species were similar to functioning organs in other species, biologists concluded two otherwise dissimilar creatures must have shared a common ancestor. (
  • An allograft is a transplanted organ or tissue from a genetically non-identical member of the same species . (
  • A transplant of organs or tissue from one species to another. (
  • In 1969, Dr David Hume of the Medical College of Virginia, in cooperation with Dr Bernard Amos of Duke University, organized the South-Eastern Regional Organ Procurement Program (SEROPP) after determining that tissue typing provided increased graft survival for kidney recipients. (
  • Until now, scientists had not known that the kidney was a blood-generating organ. (
  • Blood generation occurs within the kidney in fish, but this is a notable discovery in mammals. (
  • Researchers have long been able to grow kidney tissue in a lab dish, successfully forming various components of the organ. (
  • Hu noted how surprising this discovery was: "Rarely do researchers find this phenomenon in organs, and for the first time we identify this phenomenon in the developing kidney," she said. (
  • We tested the hypothesis that differential expression might be concentrated at the growth control gene core (GCGC), i.e., the set of genes that underlie the molecular mechanisms of genetic control of tissue and organ growth and body size, as demonstrated in model organisms. (
  • That there are areas where the complicated mechanisms of individual organs vary can make this difficult. (
  • The Tseng lab works to identify mechanisms of organ regeneration using the Xenopus (African clawed frog) model. (
  • Zebrafish (ZF, Danio rerio ) exhibit a high degree of resemblance in their genetic profile (69% of the their genes have at least one human ortholog [ 1 ]), molecular mechanisms, cell development, and organ physiology to humans [ 2 ]. (
  • It was the builder's desire that the organ through its scaling, voicing and tonal finishing would hopefully project a warm "joyful" sound to the listener. (
  • Electrically powered reed organs appeared during the first decades of electricity, but their tonal qualities remained much the same as the older, foot-pumped models. (
  • However by 120 hpf most structures in the rapamycin-treated embryos ultimately developed, with the notable exception of the digestive organs. (
  • Prior to 72 hpf, the size of the organs are concordant with the developmental stage, which is known to be delayed as seen in panels A and B. Embryos treated with rapamycin show a marked deceleration of digestive system growth after 72 hpf. (
  • We no longer rely on these organs or structures for any serious function, or they have atrophied or degenerated to the point that they don't serve the function they used to. (
  • One could also propose harvesting viable organs, in which case the execution could place professionally by a surgeon, in an OR. (
  • Consequently, the organ runs on much higher wind pressures than most organs in order to achieve a volume loud enough to fill the hall. (
  • Additionally, compliant vessels can maintain adequate perfusion pressures to provide proper blood supply to organs so that they can function and perform properly. (
  • The organ has four entries in Guinness World Records, including "Largest pipe organ ever constructed", "Largest musical instrument ever constructed" and "Loudest musical instrument ever constructed", and holds several records in the organ world. (
  • The church's first pipe organ was a two-manual Hook and Hastings instrument dedicated on February 26, 1888, in the new Methodist Block three-story brick building located at the corner of 4th and Broadway in downtown San Diego. (
  • The Global Medical Bionic Implant & Artificial Organs Market is growing continuously and expected to grow at a CAGR of 7.0% from 2018 to 2023. (
  • The global medical bionic implant/artificial organs market is expected to gain prominence over the forecast period (2018-2023). (
  • In this case, the assumption is that the research has the noble aim of solving the shortage of human organs and, as long as precautionary measures are taken to ensure safety and respect for the welfare the animals, then research should be allowed to go ahead. (
  • They suppress the immune system so that the body does not identify the new organ as foreign and reject it. (
  • Transplant rejection occurs when the immune system of the recipient of a transplant attacks the transplanted organ or tissue. (
  • Read more on notable black scientists. (
  • Despite this, the new organ is not rejected, as scientists from the Helmholtz Zentrum München and the Technische Universität München (TUM) have now discovered. (
  • At the same time he introduced the art of organ improvisation to the country as a coast-to-coast recitalist. (
  • Most notable Euplokamis-specific features are the following: (a) Comb nerves with giant axons. (
  • These nerves directly coordinate the rapid escape response bypassing the central integrative structure known as the aboral sensory organ. (
  • Future development of the integrated tissue-organ printer is being directed to the production of tissues for human applications, and to the building of more complex tissues and solid organs," Atala told Quartz . (
  • We will be using similar strategies to print solid organs. (
  • Various types of electronic organs have been brought to market over the years, with some establishing solid reputations in their own niche markets. (
  • Several organ-preservation solutions are available, and these are being constantly modified to provide improved organ storage and outcomes. (
  • Therefore, organ-preservation solutions are hypertonic to minimize these alterations. (
  • Where the Organ Preservation Solutions is market heading? (
  • Much opportunity remains in this growing Organ Preservation Solutions Market. (
  • The report also includes profiles and for some of the leading companies in the Organ Preservation Solutions Market, with a focus on this segment of these companies' operations. (
  • Overall world revenue for Organ Preservation Solutions Market will surpass $xx million in 2021, our work calculates. (
  • Revenue forecasts to 2031 for 5 regional and 16 key national markets - See forecasts for the Organ Preservation Solutions market in North America, Europe, Asia-Pacific and Rest of the World. (
  • Youthful vigor can be maintained when various organs and systems are working properly. (
  • His findings suggest there may be a "point of return" in which medicines might help severely aged organs to recover a youthful state. (
  • Some organs, such as the urinary bladder, have been eliminated. (
  • Suprapubic pain happens in your lower abdomen near where your hips and many important organs, such as your intestines, bladder, and genitals, are located. (
  • Their most notable advantage is the presence of a swim bladder. (
  • Some adaptations snakes have made to having a long, limbless body are internal organs that are arranged very differently than those of other animals. (
  • A key component of the equipment to create the synthetic organ was made by researchers at Harvard Bioscience in Holliston, Massachusetts. (
  • Fortunately, XoVitality™ Heart & Brain delivers a comprehensive and powerful blend of ingredients that protect the heart and brain, revitalizing these key organs and systems, and allowing you to enjoy a new vitality for years to come. (
  • As a result, her other organs gradually began to fail, said her doctor, Mitchell Saltzberg, medical director of the heart failure and transplant program at Froedtert & the Medical College of Wisconsin. (
  • In that study, 1000 mg/kg/day was considered to be well tolerated with no effects recorded on clinical observations, body weight or food consumption profiles, organ weights or macroscopic investigations and therefore a suitable high dose level for this 13 Week Toxicity study. (
  • An organ transplant is the moving of a whole or partial organ from one body to another (or from a donor site on the patient's own body), for the purpose of replacing the recipient's damaged or failing organ with a working one from the donor site. (
  • or other symptoms depending on the organ or body system involved. (
  • What Organs Are on the Left Side of the Body? (
  • Human SALL4 mutations are associated with the Duane-radial ray syndrome (Okihiro syndrome), a human autosomal-dominant disease involving multiple organ defects ( 3 , 5 , 6 ). (
  • Bionic implants are artificially engineered devices that are implanted into a human to replace a natural organ. (
  • Although it does not state it explicitly, the NIH announcement seems to have been triggered by Harvard professor George Church 's research on growing humanised organ models in non-human animals, namely pigs . (
  • Without that, there's no hope of creating a functional organ. (
  • A functional amino acid may be loosely defined as an amino acid with notable and significant physiological effects. (
  • Cahill's techniques were later used by Laurens Hammond in his organ design, and the 200-ton Telharmonium served as the world's first demonstration of electrically produced music on a grand scale. (
  • Built in Belleville, Ontario, the Robb Wave Organ predates its much more successful competitor Hammond by patent and manufacture, but shut down its operations in 1938 due to lack of funding. (
  • A typical tonewheel organ, Hammond B3 . (
  • [8] The Hammond organ quickly became the successor of the reed organ, displacing it almost completely. (
  • and secondary organ failure of uncertain etiology leading to death (one patient). (
  • Tissue markers, history of RCC, and characteristic histological appearances often aid in the appropriate classification and distinction between primary and secondary organ disease [1]. (
  • He will give an insight into his work on the development of bioprinted mini-organs in the field of state-of-the-art tissue engineering. (
  • Members of the ER family of RLKs collectively promote cell proliferation and organ development ( 15 ). (
  • The development of other symptoms in SLE varies depending on the organs affected. (
  • Rapid development of healthcare industry in many nations across the globe is anticipated to positively impact the growth of the organ on a chip market. (
  • In addition to this, increasing spending on the development of healthcare infrastructure is envisioned to bolster the growth of organ on a chip market. (
  • Similarly, substantial funding for the development of organ on chip is expected to fuel the growth of the organ on a chip market. (
  • This concept played an important role in the development of the electric organ. (
  • At the time, some manufacturers thought that emulation of the pipe organ was the most promising route to take in the development of an electronic organ. (
  • Perfusion pressure is the pressure that pushes blood into an organ. (
  • When healthy, it is a small organ approximately 4 inches long. (
  • Techniques for organ preservation serve to minimize this damage to promote optimal graft survival and function. (
  • Adequate blood supply to an organ improves the chances of providing adequate supply of oxygen and nutrients to the organ so that it can perform properly. (
  • Acute increases in vascular leakage to macromolecules closely coincide with tissue injury of many etiologies, and can result in fluid loss, edema, and organ dysfunction ( 1 - 3 ). (