A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Inorganic salts of the hypothetical acid, H3Fe(CN)6.
Drugs used to cause dilation of the blood vessels.
A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Men and women working in the provision of health services, whether as individual practitioners or employees of health institutions and programs, whether or not professionally trained, and whether or not subject to public regulation. (From A Discursive Dictionary of Health Care, 1976)
Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.
Hydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
The total amount of a chemical, metal or radioactive substance present at any time after absorption in the body of man or animal.
The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.
The smallest divisions of the arteries located between the muscular arteries and the capillaries.
The minute vessels that collect blood from the capillary plexuses and join together to form veins.
Situations or conditions requiring immediate intervention to avoid serious adverse results.
Drugs that cannot be sold legally without a prescription.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
Insurance providing for payment of services rendered by the pharmacist. Services include the preparation and distribution of medical products.
Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.
Directions written for the obtaining and use of DRUGS.
A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.
Compound isolated from Cannabis sativa extract.
Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.
Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)
The plant genus in the Cannabaceae plant family, Urticales order, Hamamelidae subclass. The flowering tops are called many slang terms including pot, marijuana, hashish, bhang, and ganja. The stem is an important source of hemp fiber.
A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound.
A physiologically inactive constituent of Cannabis sativa L.
A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
Contraceptive devices placed high in the uterine fundus.
Prevention of CONCEPTION by blocking fertility temporarily, or permanently (STERILIZATION, REPRODUCTIVE). Common means of reversible contraception include NATURAL FAMILY PLANNING METHODS; CONTRACEPTIVE AGENTS; or CONTRACEPTIVE DEVICES.
Intrauterine contraceptive devices that depend on the release of metallic copper.
Chemical substances or agents with contraceptive activity in females. Use for female contraceptive agents in general or for which there is no specific heading.
Spontaneous loss of INTRAUTERINE DEVICES from the UTERUS.
An abnormal direct communication between an artery and a vein without passing through the CAPILLARIES. An A-V fistula usually leads to the formation of a dilated sac-like connection, arteriovenous aneurysm. The locations and size of the shunts determine the degree of effects on the cardiovascular functions such as BLOOD PRESSURE and HEART RATE.
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.

Phospholamban is present in endothelial cells and modulates endothelium-dependent relaxation. Evidence from phospholamban gene-ablated mice. (1/3024)

Vascular endothelial cells regulate vascular smooth muscle tone through Ca2+-dependent production and release of vasoactive molecules. Phospholamban (PLB) is a 24- to 27-kDa phosphoprotein that modulates activity of the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA). Expression of PLB is reportedly limited to cardiac, slow-twitch skeletal and smooth muscle in which PLB is an important regulator of [Ca2+]i and contractility in these muscles. In the present study, we report the existence of PLB in the vascular endothelium, a nonmuscle tissue, and provide functional data on PLB regulation of vascular contractility through its actions in the endothelium. Endothelium-dependent relaxation to acetylcholine was attenuated in aorta of PLB-deficient (PLB-KO) mice compared with wild-type (WT) controls. This effect was not due to actions of nitric oxide on the smooth muscle, because sodium nitroprusside-mediated relaxation in either denuded or endothelium-intact aortas was unaffected by PLB ablation. Relative to denuded vessels, relaxation to forskolin was enhanced in WT endothelium-intact aortas. The endothelium-dependent component of this relaxation was attenuated in PLB-KO aortas. To investigate whether these changes were due to PLB, WT mouse aorta endothelial cells were isolated. Both reverse transcriptase-polymerase chain reaction and Western blot analyses revealed the presence of PLB in endothelial cells, which were shown to be >98% pure by diI-acetylated LDL uptake and nuclear counterstaining. These data indicate that PLB is present and modulates vascular function as a result of its actions in endothelial cells. The presence of PLB in endothelial cells opens new fields for investigation of Ca2+ regulatory pathways in nonmuscle cells and for modulation of endothelial-vascular interactions.  (+info)

Endogenous endothelin-1 depresses left ventricular systolic and diastolic performance in congestive heart failure. (2/3024)

Endothelin-1 (ET-1) is a positive inotrope in normal hearts; however, the direct cardiac effects of endogenous ET-1 in congestive heart failure (CHF) are unknown. We evaluated the cardiac responses to endogenous ET-1 using an ETA and ETB receptor blocker (L-754,142) in seven conscious dogs before and after pacing-induced CHF. Before CHF, when the plasma ET-1 was 7.3 +/- 1.7 fmol/ml, L-754,142 caused no significant alterations in heart rate, left ventricular (LV) end-systolic pressure, total systemic resistance, and the time constant of LV relaxation (tau). LV contractile performance, measured by the slopes of LV pressure (P)-volume (V) relation (EES), dP/dtmax-end-diastolic V relation (dE/dtmax), and stroke work-end-diastolic V relation, was also unaffected. After CHF, when the plasma ET-1 was significantly increased to 14.1 +/- 3.0 fmol/ml (p <.05), L-754,142 produced a significant decreases in LV end-systolic pressure (101 +/- 11 versus 93 +/- 8 mm Hg) and total systemic resistance (0.084 +/- 0.022 versus 0.065 +/- 0.15 mm Hg/ml/min). The tau (42 +/- 12 versus 38 +/- 10 ms), mean left atrial P (22 +/- 5 versus 18 +/- 4 mm Hg) (p <.05), and minimum LVP were also significantly decreased. After CHF, the slopes of P-V relations, EES (3.4 +/- 0.4 versus 4.8 +/- 0.8 mm Hg/ml), dE/dtmax (42.4 +/- 7.8 versus 50.0 +/- 7.8 mm Hg/s/ml), and stroke work-end-diastolic V relation (58.1 +/- 3.3 versus 72.4 +/- 5.2 mm Hg) (p <.05) all increased after L-754,142, indicating enhanced contractility. Before CHF, low levels of endogenous ET-1 have little cardiac effect. However, after CHF, elevated endogenous ET-1 produces arterial vasoconstriction, slows LV relaxation, and depresses LV contractile performance. Thus, elevated endogenous ET-1 may contribute to the functional impairment in CHF in this canine model.  (+info)

Studies of the role of endothelium-dependent nitric oxide release in the sustained vasodilator effects of corticotrophin releasing factor and sauvagine. (3/3024)

1. The mechanisms of the sustained vasodilator actions of corticotrophin-releasing factor (CRF) and sauvagine (SVG) were studied using rings of endothelium de-nuded rat thoracic aorta (RTA) and the isolated perfused rat superior mesenteric arterial vasculature (SMA). 2. SVG was approximately 50 fold more potent than CRF on RTA (EC40: 0.9 +/- 0.2 and 44 +/- 9 nM respectively, P < 0.05), and approximately 10 fold more active in the perfused SMA (ED40: 0.05 +/- 0.02 and 0.6 +/- 0.1 nmol respectively, P < 0.05). Single bolus injections of CRF (100 pmol) or SVG (15 pmol) in the perfused SMA caused reductions in perfusion pressure of 23 +/- 1 and 24 +/- 2% that lasted more than 20 min. 3. Removal of the endothelium in the perfused SMA with deoxycholic acid attenuated the vasodilatation and revealed two phases to the response; a short lasting direct action, and a sustained phase which was fully inhibited. 4. Inhibition of nitric oxide synthase with L-NAME (100 microM) L-NMMA (100 microM) or 2-ethyl-2-thiopseudourea (ETPU, 100 microM) had similar effects on the vasodilator responses to CRF as removal of the endothelium, suggesting a pivotal role for nitric oxide. However the selective guanylate cyclase inhibitor 1H-[l,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ, 10 microM) did not affect the response to CRF. 5. High potassium (60 mM) completely inhibited the vasodilator response to CRF in the perfused SMA, indicating a role for K channels in this response. 6. Compared to other vasodilator agents acting via the release of NO, the actions of CRF and SVG are strikingly long-lasting, suggesting a novel mechanism of prolonged activation of nitric oxide synthase.  (+info)

Growth-inhibitory effect of cyclic GMP- and cyclic AMP-dependent vasodilators on rat vascular smooth muscle cells: effect on cell cycle and cyclin expression. (4/3024)

1. The possibility that the antiproliferative effect of cyclic GMP- and cyclic AMP-dependent vasodilators involves an impaired progression of vascular smooth muscle cells (VSMC) through the cell cycle and expression of cyclins, which in association with the cyclin-dependent kinases control the transition between the distinct phases of the cell cycle, was examined. 2. FCS (10%) stimulated the transition of quiescent VSMC from the G0/G1 to the S phase (maximum within 18-24 h and then to the G2/M phase (maximum within 22-28 h). Sodium nitroprusside and 8-Br-cyclic GMP, as well as forskolin and 8-Br-cyclic AMP markedly reduced the percentage of cells in the S phase after FCS stimulation. 3. FCS stimulated the low basal protein expression of cyclin D1 (maximum within 8-24 h) and E (maximum within 8-38 h) and of cyclin A (maximum within 14-30 h). The stimulatory effect of FCS on cyclin D1 and A expression was inhibited, but that of cyclin E was only minimally affected by the vasodilators. 4. FCS increased the low basal level of cyclin D1 mRNA after a lag phase of 2 h and that of cyclin A after 12 h. The vasodilators significantly reduced the FCS-stimulated expression of cyclin D1 and A mRNA. 5. These findings indicate that cyclic GMP- and cyclic AMP-dependent vasodilators inhibit the proliferation of VSMC by preventing the progression of the cell cycle from the G0/G1 into the S phase, an effect which can be attributed to the impaired expression of cyclin D1 and A.  (+info)

Maintenance of normal agonist-induced endothelium-dependent relaxation in uraemic and hypertensive resistance vessels. (5/3024)

BACKGROUND: The nitric oxide system has been implicated in several diseases with vascular complications including diabetes mellitus and hypertension. Despite the high prevalence of hypertension and cardiovascular complications in renal failure few studies have examined vascular and endothelial function in uraemia. We therefore chose to study possible abnormalities of the nitric oxide vasodilator system in an animal model of chronic renal failure. METHODS: Adult spontaneous hypertensive rats and Wistar Kyoto rats were subjected to a 5/6 nephrectomy with control animals having sham operations. After 4 weeks blood pressure was recorded and the animals were sacrificed. Branches of the mesenteric arteries were isolated and mounted on a Mulvany myograph. All experiments were performed in the presence of indomethacin (10(-5) M). The vessels were first preconstricted with noradrenaline, exposed to increasing concentrations of acetylcholine (10(-8) to 10(-4) M) and subsequently to sodium nitroprusside (10(-5) M). RESULTS: There was no difference in the relaxation of the four groups of vessels to any of the concentrations of acetylcholine used nor was there any significant difference in the EC50s (control Wistar Kyoto 6.1+/-1.4 x 10(-8) M; uraemic Wistar Kyoto 5.4+/-0.8 x 10(-8) M; control spontaneous hypertensive rats 4.5+/-0.6 x 10(-8) M; uraemic spontaneous hypertensive rats 6+/-0.7 x 10(-8) M). Vasodilatation in response to sodium nitroprusside was unchanged in uraemic vessels. In addition the vascular responses to both acetylcholine and sodium nitroprusside were unaltered in spontaneous hypertensive rats. CONCLUSIONS: We conclude that normal agonist-induced endothelium-dependent relaxation is maintained in experimental uraemia and hypertension.  (+info)

Regulation of sympathetic nerve activity in heart failure: a role for nitric oxide and angiotensin II. (6/3024)

The mechanisms by which sympathetic function is augmented in chronic heart failure (CHF) are not well understood. A previous study from this laboratory (Circ Res. 1998;82:496-502) indicated that blockade of nitric oxide (NO) synthesis resulted in only an increase in renal sympathetic nerve activity (RSNA) when plasma angiotensin II (Ang II) levels were elevated. The present study was undertaken to determine if NO reduces RSNA in rabbits with CHF when Ang II receptors are blocked. Twenty-four New Zealand White rabbits were instrumented with cardiac dimension crystals, a left ventricular pacing lead, and a pacemaker. After pacing at 360 to 380 bpm for approximately 3 weeks, a renal sympathetic nerve electrode and arterial and venous catheters were implanted. Studies were carried out in the conscious state 3 to 7 days after electrode implantation. The effects of a 1-hour infusion of sodium nitroprusside (SNP; 3 microgram . kg-1. min-1) on RSNA and mean arterial pressure (MAP) were determined before and after Ang II blockade with losartan (5 mg/kg) in normal and CHF rabbits. Changes in MAP were readjusted to normal with phenylephrine. Before losartan, SNP evoked a decrease in MAP and an increase in RSNA in both groups that was baroreflex-mediated, because both MAP and RSNA returned to control when phenylephrine was administered. In the normal group, losartan plus SNP caused a reduction in MAP and an increase in RSNA that was 152.6+/-9.8% of control. Phenylephrine returned both MAP and RSNA back to the control levels. However, in the CHF group, losartan plus SNP evoked a smaller change in RSNA for equivalent changes in MAP (117.1+/-4.1% of control). On returning MAP to the control level with phenylephrine, RSNA was reduced to 65.2+/-2.9% of control (P<0. 0001). These data suggest that endogenous Ang II contributes to the sympathoexcitation in the CHF state and that blockade of Ang II receptors plus providing an exogenous source of NO reduces RSNA below the elevated baseline levels. We conclude that both a loss of NO and an increase in Ang II are necessary for sustained increases in sympathetic nerve activity in the CHF state.  (+info)

Heat shock protein expression in umbilical artery smooth muscle. (7/3024)

Postpartum vasospasm in the umbilical arteries may be due to impaired vasorelaxation secondary to alterations in the expression of heat shock proteins. The contractile responses of pre- and full-term bovine umbilical artery smooth muscles were determined in a muscle bath. Heat shock protein expression was determined in bovine and human arterial tissues using western blotting with specific antisera. Full-term bovine and human umbilical artery smooth muscle was refractory to relaxation induced by the nitric oxide donor, sodium nitroprusside. This impaired vasorelaxation was associated with the expression of the inducible form of the heat shock protein, HSP70i, and increases in the expression of the small heat shock protein, HSP27. Small heat shock proteins have been implicated in modulating contraction and relaxation responses in vascular smooth muscles. Thus, alterations in heat shock protein expression may play a role in umbilical artery vasospasm.  (+info)

Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats. (8/3024)

AIM: To study the effect of intrahippocampal infusion of interleukin-6 (IL-6) on active avoidance in rats and the possible involvement of nitric oxide (NO). METHODS: Using a shuttle-box model, the effects of bilaterally intrahippocampal infusion of IL-6 3.2, 16, and 80 ng as well as sodium nitroprusside (SNP) 400 ng on active avoidance were studied on d 8 after administration. The levels of nitrite as an index of NO in the hippocampus were detected using a fluorometric assay 24 h after infusion of IL-6 3.2 or 80 ng. RESULTS: IL-6 16 and 80 ng impaired the acquisition performance of active avoidance by prolonging the latency of avoidance in training, but not the retention performance in testing. IL-680 ng and SNP 400 ng also resulted in a marked impairment in acquisition performances by decreasing the rate of avoidance, but not in retention performances. IL-680 ng markedly elevated the nitrite levels from 10.6 +/- 0.7 in control rats to 13.6 +/- 2.0 (nmol/g wet wt) (P < 0.01). IL-6 3.2 ng had no effect on active avoidance nor on nitrite levels. CONCLUSION: Intrahippocampal infusion of IL-6 impaired learning acquisition of active avoidance in rats.  (+info)

TY - JOUR. T1 - Sodium nitroprusside exacerbates myocardial ischemia-reperfusion injury. AU - Cope, Jeffrey T.. AU - Banks, David. AU - Laubach, Victor E.. AU - Binns, Oliver A.R.. AU - King, R. Christopher. AU - Richardson, R. Mark. AU - Shockey, Kimberly S.. AU - Tribble, Curtis G.. AU - Kron, Irving L.. PY - 1997/12/1. Y1 - 1997/12/1. N2 - Background. The role of nitric oxide in myocardial ischemia-reperfusion is controversial. Although many studies claim that nitric oxide ameliorates reperfusion injury, others suggest that it exacerbates such injury, possibly through peroxynitrite production. These discordant results may be attributable to a dose-dependent phenomenon. Methods. Isolated rabbit hearts sustained sequential periods of blood perfusion (20 minutes), warm ischemia (30 minutes), and reperfusion (20 minutes). During reperfusion, four groups underwent intracoronary infusion of saline solution (n = 6), or the nitric oxide donor sodium nitroprusside (100 nm/min [SNP100, n = 6], 1 nmol ...
Efficient gene transfer by vectors that can be easily delivered to target organs is desirable in clinical gene therapy. We tested the hypothesis that intracoronary infusion of the nitric oxide donor nitroprusside would increase the efficiency of adenovirus vector-mediated gene transfer to the heart. Intracoronary delivery of an adenovirus encoding murine adenylyl cyclase type VI (Ad.AC(VI)) was performed in adult pigs with and without simultaneous intracoronary infusion of nitroprusside. Animals were killed 12-14 days after Ad.AC(VI) delivery and myocardial adenylyl cyclase activity was measured. Addition of nitroprusside during intracoronary infusion of Ad.AC(VI) was associated with a 4-fold increase in cAMP-generating capacity in the left ventricle. Transgene expression was confirmed by immunoblotting. Intracoronary nitroprusside produced mild dose-dependent changes in blood pressure and heart rate during infusion. Intracoronary nitroprusside infusion is a safe and effective means to increase ...
Nitroprusside - Get up-to-date information on Nitroprusside side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Nitroprusside
Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency. [Wikipedia]
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Sodium nitroprusside or SNP is a chemical compound, often encountered as dihydrate. It is sold under the brand name Nitropress among others as a medication used to lower blood pressure. ...
Nitroprusside is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries.
Learn about the potential side effects of nitroprusside. Includes common and rare side effects information for consumers and healthcare professionals.
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Recent studies have shown that nitric oxide (NO) may be involved in diverse plant developmental processes as an important signal molecule. However, the effects of NO on vegetative and reproductive growth of intact plants are not fully understood. In our study, the NO donor sodium nitroprusside (SNP) at 3,000, 6,000 and 9,000 μM was used to characterize the roles of NO in vegetative and reproductiv ...
1 The aim of this study was to examine whether sodium nitroprusside (SNP)-induced relaxation of rat fundus longitudinal smooth muscle involves ryanodine-sensitive Ca2+ release. 2 SNP (300 nM-30 microM) elicited concentration-dependent relaxation of precontracted (1 microM carbachol) rat fundus, an effect almost abolished by the selective guanylyl cyclase inhibitor, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one (ODQ, 10 microM). 3 SNP-mediated relaxations were almost abolished by 10 microM ryanodine. 4 SNP-mediated relaxations were also reduced by either 1 microM apamin (a selective small conductance Ca(2+)-sensitive K+ channel, SKCa, inhibitor) or the selective L-type Ca2+ channel inhibitor, nicardipine (3 microM). 5 SNP-induced relaxations were insensitive to 1 mM tetraethylammonium chloride (an inhibitor of large-conductance Ca(2+)-sensitive K+ channels) and 1 microM glibenclamide (an ATP-sensitive K+ channel inhibitor). 6 These data suggest that SNP-mediated fundus relaxation occurs via a ...
Since the mechanism of salt impairing NO-induced vascular relaxation is not fully clear, this study was designed to investigate the role of potassium (K+) channels in the vasodilatory effects of NO donor in salt loaded rats. Isolated thoracic aortic rings of adult male albino rats fed 8% NaCl containing diet for six weeks were used for isometric tension recording using PowerLab tissue bath system. The recorded data revealed that high salt diet (HS) did not change the relaxation responses to sodium nitroprusside (SNP, an NO donor) in rats thoracic aortic rings. SNP-induced relaxation in salt loaded rats was significantly lower in rings contracted by high K+ than phenylephrine (PE, a selective α1-adrenergic receptor agonist). On the other hand, incubation of aortic rings from salt loaded rats with inward-rectifier K+ (KIR) channel blockers either individually or simultaneously with other K+ channel blockers significantly inhibited SNP-induced relaxation in PE-contracted rings; however incubation ...
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In an open-label study, we compared the efficacy and safety of intravenous infusion of fenoldopam mesylate with that of sodium nitroprusside in patients with severe hypertension or in hypertensive crisis. Both antihypertensive medications were infused at a maximal dose increment of 0.2 microgram/kg/min (fenoldopam) and 1 microgram/kg/min (nitroprusside), with a maximal infusion rate of 1.5 micrograms/kg/min fenoldopam mesylate or 8 micrograms/kg/min sodium nitroprusside. Once the desired reduction in diastolic blood pressure was achieved (less than 110 mm Hg if initial diastolic blood pressure was 120-149 mm Hg, or by at least 40 mm Hg if initial diastolic blood pressure was 150-190 mm Hg), the maximal infusion rate used was maintained for at least 1 hour, and then, the infusion was slowed gradually over 2 hours. After the infusion treatment, patients remained in the hospital for 2 days of follow-up. Both antihypertensive agents successfully controlled the blood pressure in all the patients by ...
TY - JOUR. T1 - Apoptotic insults to human chondrocytes induced by sodium nitroprusside are involved in sequential events, including cytoskeletal remodeling, phosphorylation of mitogen-activated protein kinase kinase kinase-1/c-jun N-terminal kinase, and baxmitochondria-mediated caspase activation. AU - Cherng, Yih Giun. AU - Chang, Huai Chia. AU - Lin, Yi Ling. AU - Kuo, Ming Liang. AU - Chiu, Wen Ta. AU - Chen, Ruei Ming. PY - 2008/7. Y1 - 2008/7. N2 - Nitric oxide (NO) can regulate chondrocyte activities. This study was aimed to evaluate the molecular mechanisms of NO donor sodium nitroprusside (SNP)-induced insults to human chondrocytes. Exposure of human chondrocytes to SNP increased cellular NO levels but decreased cell viability in concentration- and time-dependent manners. SNP time dependently induced DNA fragmentation and cell apoptosis. Treatment with 2-phenyl-4,4,5,5-tetramethyl-imidazoline-l-oxyl 3-oxide, an NO scavenger, significantly lowered SNP-induced cell injuries. ...
TY - JOUR. T1 - Nitroprusside in decompensated heart failure. T2 - What should a clinician really know?. AU - Opasich, Cristina. AU - Cioffi, Giovanni. AU - Gualco, Alessandra. PY - 2009. Y1 - 2009. N2 - Sodium nitroprusside is an older intravenous vasodilator appropriate for acute hospital treatment of patients with congestive heart failure. It is a balanced arterial and venous vasodilator with a very short half-life, facilitating rapid titration. In general, it improves hemodynamic and clinical status by reducing systemic vascular resistance, left ventricular filling pressure, and increasing cardiac output. This review summarizes recently published literature and recent data regarding the use of this intravenous vasodilator in decompensated heart failure patients.. AB - Sodium nitroprusside is an older intravenous vasodilator appropriate for acute hospital treatment of patients with congestive heart failure. It is a balanced arterial and venous vasodilator with a very short half-life, ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
Pulmonary arterial hypertension (PAH) is a rare blood vessel disorder of the lung in which the pressure in the pulmonary artery (PA) rises above normal levels and may become life threatening. PAH is frequently misdiagnosed and has often progressed to late stage by the time it is accurately diagnosed. PAH has been historically chronic and incurable with a poor survival rate. However, new treatments are available which have significantly improved prognosis. Right-heart catheterization (RHC) is the most accurate and useful test for PAH, and the only test that directly measures the pressure inside the PA. It is performed in all patients at least once, to get a definitive diagnosis of PAH.. The most commonly used medication for this purpose is intravenous nitroprusside, however this medication in about 25-30% of patients is not well tolerated as it cause fast heart rates, which is not well tolerated by patients with pulmonary hypertension and/or heart failure. The CARVE study assesses the effect of ...
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Frog sciatic nerves were isolated into Groups: -Control Group-incubation in Ringers solution; SNP Group- incubation in 10-² M sodium nitroprusside solution; SNP+DEX Group-incubation in 10-² M sodium nitroprusside solution followed by incubation in 10-³ M dexamethasone solution; DEX group- incubation in 10-³ M dexamethasone solution. ...
In the most extreme cases of UFOV restriction, individuals are sensitive to distraction and are unable to divide their atten- tion effectively between central and peripheral viewing tasks. 2913 Sodium nitroprusside .
TY - JOUR. T1 - Synergistic interaction between the Ligusticum chuanxiong constituent butylidenephthalide and the nitric oxide donor sodium nitroprusside in relaxing rat isolated aorta. AU - Chan, S.S.. AU - Jones, R.. AU - Lin, G.. PY - 2009. Y1 - 2009. N2 - Ligusticum chuanxiong Hort. (Umbelliferae), a traditional Chinese medicinal herb, is often prescribed together with nitric oxide donors for treating coronary heart diseases such as angina in China; however, studies concerning their pharmacological interaction are scarce. The objective of the present study was to examine the interaction between the Ligusticum chuanxiong major active constituent butylidenephthalide (BDPH) and the nitric oxide donor sodium nitroprusside (SNP) in vasorelaxation. Vasorelaxation was examined in rat isolated aorta using an organ bath system. BDPH and SNP interacted synergistically under 9,11-dideoxy-9α,11α-methanoepoxyprostaglandin H2 (U-46619)-induced tone. This synergism became greater with increasing U-46619 ...
The aim of this study is to evaluate the effect of pre PCI administration of intracoronary nitroprusside on post procedural myonecrosis. Myonecrosis is a prognostically important complication of PCI. Nitric oxide is a potent vasodilator in the resistance arteriolar circulation, and plays a significant role in the control of coronary blood flow through the microcirculation. nitroprussideis a direct donor of nitric oxide. A total of 62 patients were randomized into the NTP (n= 31) or control (n= 31) group. Patients who were scheduled for non-urgent PCI in de novo native coronary arteries were eligible. All patients were pretreated with statin, aspirin and clopidogrel. Myonecrosis was measured by CK-MB elevation 24 h after PCI. The NTP group received intracoronary NTP befor PCI, whereas the control group did not. All patients in NPT group received NTP for prevention of myonecrosis at a dose of at least 50 μg given intrcoronary through guiding catheter. 22 patients received 50μg,7 patients ...
Nitric oxide (NO) as well as its donors has been shown to generate mutation and DNA damage in in vitro assays. The objective of this study was to identify that DNA single-strand breaks (SSBs) could be elicited by NO, not only in vitro but also in vivo. The alkaline single-cell gel electrophoresis (SCGE) was performed to examine the DNA damage in g12 cells and the cells isolated from the organs of mice exposed to sodium nitroprusside (SNP). A modified method, in which neither collagenase nor trypsin was necessary, was used to prepare the single-cell suspension isolated from organs of mice. Results showed that the exposure of g12 cells to 0.13-0.5 mu mol/ml SNP with S9 for 1 h induced a concentration-dependent increase in DNA SSBs in g12 cells. The significant increase in DNA migration and comet frequency has appeared in the cells isolated from the spleen, thymus, and peritoneal macrophages of mice after injecting i.p. SNP in the dosage range of 0.67-6.0 mg/kg b.wt for 1 h. However, no obvious ...
Nitric oxide (Zero) is certainly essential in the regulations of bone fragments remodeling, whereas high concentration of Zero promotes cell death of osteoblast. in dosage- and time-dependent way. SNP elevated phrase amounts of g62, ATG7, LC3-II and Beclin-1, as regular autophagic indicators and increased acidic autophagolysosomal vacuoles, discovered by acridine tangerine discoloration. Nevertheless, pretreatment with 3-methyladenine (3MA), the particular inhibitor for autophagy, reduced cell viability, whereas elevated the cleavage of PARP and caspase-3 in the SNP-treated MC3Testosterone levels3-Age1 cells. AMP-activated proteins kinase (AMPK), a main autophagy regulatory kinase, was turned on in SNP-treated MC3Testosterone levels3-Age1 cells. In addition, pretreatment with substance C, an inhibitor of AMPK, reduced cell viability, whereas elevated the accurate amount of apoptotic cells, cleaved PARP and caspase-3 amounts likened to those of SNP-treated MC3Testosterone levels3-Age1 cells. Used ...
Cannabidiol acts in pathways associated with psychotic symptoms and may be important in the management of psychotic states and psychosis.
1. The contraction and relaxation responses to the polyoxyethylated vehicles currently used for the intravenous and oral administration of cyclosporin A in allograft recipients were studied in isolated rat aorta. The results were compared with those obtained with commercially available cyclosporin A for intravenous administration.. 2. None of these compounds affected resting tension, noradrenaline-induced contraction or endothelium-independent relaxation produced by sodium nitroprusside or bumetanide. However, they all reversed the relaxation induced by acetylcholine, carbamylcholine or adenosine 5′-triphosphate, by a factor of approximately 66%.. 3. This reversal of relaxation was unaffected by indomethacin and did not require the presence of cyclosporin A in the vehicles, and was completely abolished by l-arginine (3 × 10−-5 mol/l).. 4. It is concluded that vehicles used for commercial preparations of cyclosporin A interfere with the synthesis of endothelium-derived relaxing factor at an ...
DE Newby, S Masumori, NA Boon, DJ Webb; Angiotensin II Does Not Contribute to Basal Forearm Vascular Tone in Healthy Man. Clin Sci (Lond) 1 July 1996; 91 (s35): 8P-9P. doi: https://doi.org/10.1042/cs091008Pc. Download citation file:. ...
Control of physiological states such as mean arterial pressure (MAP) has been successfully achieved using single drug by different control algorithms. Multi-drug delivery demonstrates a significantly challenging task as compared to control with a single-drug. Also the patients sensitivity to the drugs varies from patient to patient. Therefore, the implementation of adaptive controller is very essential to improve the patient care in order to reduce the workload of healthcare staff and costs. This paper presents the design and implementation of the model reference adaptive controller (MRAC) to regulate mean arterial pressure and cardiac output by administering vasoactive and inotropic drugs that are sodium nitroprusside (SNP) and dopamine (DPM) respectively. The proposed adaptive control model has been implemented, tested and verified to demonstrate its merits and capabilities as compared to the existing research work.. ...
In the reaction of [Fe(CN)5NO]3- with O2 (4:1 stoichiometry), the nitroprusside ion [Fe(CN)5NO]2- (NP) was quantitatively produced. The rate law was -1/4d[Fe(CN)5NO3-]/dt = k2[Fe(CN)5NO3-][O2], with k2 = (3.5 ± 0.2) × 105 M-1 s-1 at 25.0 C. The rate was insensitive to pH (range 9-11) and ionic strength (I = 0.1-1 M). Excess cyanide was used for minimizing the production of [Fe(CN)4NO]2-, which appeared to be much less reactive. Addition of O2 to the NO group is proposed to generate peroxynitrite bound to Fe(III), which reacts rapidly with [Fe(CN)5NO]3- to yield [Fe(CN)5NO2]3-. Reaction between the latter radical ions leads to the final product, NP. Comparison with the autoxidation rates for other NO complexes reveals that the rate constants decrease with an increase in ENO+/NO, the redox potentials of the bound NO+/NO couples. Six-coordination appears to be necessary for attaining reasonable electrophilic rates for the NO ligand, as with other heme and non-heme complexes ...
TY - JOUR. T1 - Reduction of S-T segment elevation with infusion of nitroprusside in patients with acute myocardial infarction. AU - Awan, Najam A.. AU - Miller, Richard R.. AU - Vera, Zakauddin. AU - DeMaria, Anthony N.. AU - Amsterdam, Ezra A. AU - Mason, Dean T.. PY - 1976. Y1 - 1976. N2 - The effect of infusion of sodium nitroprusside on S-T segment elevation was evaluated in 12 patlents with acute anterior myocardial infarction. Precordial 35 lead S-T segment maps were obtained in each patient immediately before and 10 minutes after infusion of 53 μ/min (range 20 to 100 μg/min) of nitroprusside. The following measurements were made from each S-T map: ∑ST (total S-T elevation in all leads), NST (number of leads with S-T elevation greater than 1 mm) and ST (average S-T elevation in leads with more than 1 mm elevation). After administration of nitroprusside, evidence of myocardial ischemic injury as assessed by S-T mapping decreased in association with reduction of the myocardial oxygen ...
Migraine is a prevalent neurological disease that is characterized by unpredictable episodic attacks of intense head pain. The underlying pathology involves sensitization and activation of the trigeminal system. Although non-invasive vagus nerve stimulation (nVNS) is recommended for the treatment of migraine, the abortive mechanism of action is not well-understood. The goal of this study was to compare the ability of nVNS and sumatriptan to inhibit trigeminal activation in two animal models of episodic migraine and to investigate the receptor mechanism of action of nVNS. Nocifensive head withdrawal response was investigated in adult male Sprague Dawley rats using von Frey filaments. To induce trigeminal nociceptor sensitization, complete Freunds adjuvant was injected in the trapezius muscle and trigeminal neurons were activated by exposure to a pungent odor or injection of the nitric oxide donor sodium nitroprusside. Some animals received nVNS or sumatriptan as treatment. Some animals were injected
To compare the hemodynamic effects of a calcium-channel blocker with those of a conventional vasodilator in the awake preinstrumented dog, diltiazem and nitroprusside were administered in equihypotensive infusions before (decrease in mean aortic pressure by 10%; p less than .001, n = 6) and after (decrease in mean aortic pressure by 12%; p less than .001) chronic volume overload (CVO) produced by an infrarenal aortocaval fistula. Diltiazem had no effect on preload either before or after CVO. The maximal rate of change in left ventricular pressure (dP/dtmax) was unaffected by diltiazem before the aortocaval fistula (decrease in dP/dtmax by 6%; p = NS) but was significantly reduced by calcium-channel blockade after CVO (decrease in dP/dtmax by 22%; p less than .001). By contrast, at matched aortic pressures nitroprusside significantly reduced left ventricular end-diastolic dimension (LVEDD) and pressure (LVEDP) in the same animals before (decrease in LVEDD by 10%, p less than .05; decrease in ...
BACKGROUND AND OBJECTIVE To determine whether magnesium sulphate could induce controlled hypotension, reduce choroidal blood flow, provide a dry operative field and could be compared with sodium nitroprusside in the recently raised issue of the use of hypotensive anaesthesia in eye surgery, i.e. for choroidal tumour surgery as the choroid is the most fragile and vascular structure in the eye. METHODS Forty adult patients undergoing choroidal melanoma resection and anaesthetized with 2.5 mg kg(-1) propofol, followed by a constant infusion of 120 microg kg(-1) min(-1), and remifentanil 1 microg kg(-1), followed by a continuous infusion of 0.25 microg kg(-1) min(-1), were randomly assigned to two groups to receive either magnesium sulphate or sodium nitroprusside. RESULTS Controlled hypotension was achieved at the target systolic pressure of 80 mmHg within 107 +/- 16 and 69 +/- 4.4 s for magnesium sulphate and sodium nitroprusside, respectively. Choroidal blood flow decreased by 24 +/- 0.3% and 22 +/
TY - JOUR. T1 - Ergotamine-induced upper extremity ischemia. T2 - A case report. AU - Man, Deuk Kim. AU - Lee, Gun. AU - Sung, Wook Shin. PY - 2005. Y1 - 2005. N2 - Ergotamine-induced limb ischemia is an extremely rare case. We present a case of a 64-year-old man, who developed ischemia on the right upper extremity due to long-term use of Ergot for migraine headache. Angiography revealed diffused, smooth, and tapered narrowing of the brachial artery. The patient was successfully treated with intravenous nitroprusside.. AB - Ergotamine-induced limb ischemia is an extremely rare case. We present a case of a 64-year-old man, who developed ischemia on the right upper extremity due to long-term use of Ergot for migraine headache. Angiography revealed diffused, smooth, and tapered narrowing of the brachial artery. The patient was successfully treated with intravenous nitroprusside.. UR - http://www.scopus.com/inward/record.url?scp=21244491560&partnerID=8YFLogxK. UR - ...
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BACKGROUND: Some studies have demonstrated beneficial effects of L-arginine as a substrate for nitric oxide synthesis, and diclofenac as an inhibitor of cyclooxygenase (COX)-derived vasoconstrictive agents on vascular responses in humans during several pathological conditions. The aim of the present study was to investigate the acute effects of L-arginine and diclofenac on endothelium-dependent vasodilatation (EDV) and endothelium-independent vasodilatation (EIDV) in patients with chronic renal failure (CRF).. METHODS: Effects of L-arginine and diclofenac on EDV and EIDV were measured in 15 patients with CRF and in 15 healthy controls by means of forearm blood flow measurements with venous occlusion plethysmography during local intra-arterial infusions of methacholine (2 and 4 micro g/min evaluating EDV) and sodium nitroprusside (5 and 10 micro g/min evaluating EIDV).. RESULTS: L-Arginine infusion increased methacholine-induced vasodilatation both in patients with CRF and healthy controls. ...
The present study was designed to test the effect of acute endogenous estrogen deprivation on endothelium-dependent vasodilation in women in reproductive age. Therefore, in a group of female patients who underwent bilateral ovariectomy for uterine leiomyoma, we evaluated the forearm vascular response to acetylcholine and sodium nitroprusside, an endothelium-dependent and -independent vasodilator, respectively. As control subjects we selected healthy women well matched with the study group population for demographic and clinical parameters. Particular attention was paid to risk factors impairing endothelial function such as age, blood pressure, phase of the menstrual cycle, lipid and glucose profile, and smoking history. In the two study populations, the response to acetylcholine and sodium nitroprusside was similar, indicating preserved endothelium-dependent vasodilation in patients with leiomyoma. In contrast, after bilateral ovariectomy, the response to acetylcholine was found to be reduced ...
Adult, Blood Pressure/drug effects, Brachial Artery/physiology, Endothelium; Vascular/*drug effects/physiology, Female, Forearm/*blood supply, Heart Rate/drug effects, Humans, Magnesium/*administration & dosage/blood, Male, Methacholine Chloride/administration & dosage, Nitric Oxide/metabolism, Nitroprusside/administration & dosage, Parasympathomimetics/administration & dosage, Plethysmography, Regional Blood Flow/drug effects, Research Support; Non-U.S. Govt, Vasodilation/*drug effects, Vasodilator Agents/administration & dosage ...
Older adults are at risk for this client to ask patients about these receptors pills name generic for generic cialis modulate the activity to develop some unrealistic solutions. 63 mental health actions/interventions establish a cause for concern, but if you are unable to probably be referred to a current situation and initiate cellular repolarization (phase 5) is called scoliosis. 7 zaleplon sonata 19 1. 3 barbiturates amobarbital aprobarbitala butabarbital barbitala mephobarbital protein binding increases adenyl cyclase increases through activation of peripheral benzodiazepine receptors. Encourage the patient who has experienced a similar sequence to botulinum toxin. The diagnosis of headaches in children. Certain drugs, such as a reservoir, toxicity may be apanied by a continuous sodium nitroprusside infusion of glucagon include dose-dependent nausea, vomiting, confusion, seizures, ora. Gov). If the victim continues to be a result of minor damage to the biologic clock will also be aware that ...
It is unknown whether and to what extent changes in various endothelial functions and adrenergic responsiveness are related to the development of microvascular complications in type 1 diabetes. Therefore, endothelium-dependent and endothelium-independent vasodilatation, endothelium-dependent hemostatic factors, and one and two adrenergic vasoconstrictor responses were determined in type 1 patients with and without microvascular complications. A total of 34 patients with type 1 diabetes were studied under euglycemic conditions on two occasions (11 without microangiopathy, 10 with proliferative and preproliferative retinopathy previously treated by laser coagulation, 13 with microalbuminuria, and 12 healthy volunteers also were studied). Forearm vascular responses to brachial artery infusions of N(G)-monomethyl-L-arginine (L-NMMA), sodium nitroprusside, acetylcholine (ACh), clonidine, and phenylephrine were determined. The ACh infusions were repeated during coinfusion of L-arginine. Furthermore, ...
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In the present study, the role of reactive oxygen species and the contribution of antioxidant defence in the time course of changes in acetylcholine-stimulated endothelium-dependent and sodium nitroprusside-stimulated endothelium-independent relaxation were investigated in aortic rings isolated from 6-month streptozotocin-diabetic and age-matched control rats. Although there were no significant differences in the degree of the peak relaxations produced by a single administration of acetylcholine (1 μM) or sodium nitroprusside (0.01 μM) between control and diabetic rings, the endothelium-dependent and -independent relaxant responses were more transient and the time required to reach a peak relaxation after addition of acetylcholine was shorter in diabetic vessels. Pretreatment of diabetic vessels with superoxide dismutase (100 U/ml) normalized the recovery phases of endothelium-dependent and -independent relaxations, but had no effect on the peak responses to acetylcholine and sodium ...
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The non-opioid pain patch market features a moderate degree of competition, says Transparency Market Research (TMR) in a new research report. The non-opioid pain patch market is a niche market in the overall pain relief market with a few key market players. Due to their strong brand names, these players have greater market penetration and operate globally.. Get Report Sample @ https://www.transparencymarketresearch.com/sample/sample.php?flag=S&rep_id=26168. North America to Account for Massive Market Share. The segment of lidocaine patches led the non-opioid pain patch market in 2015; however, due to entry of generic lidocaine patches the market share of lidocaine patches is expected to decline over the forecast period.. In 2015, North America led the non-opioid pain patch market and the region is expected to account for a massive 51.5% of the overall market by 2024. As per statistics of Global Burden of Disease, in 2014, back pain was ranked among the top ten diseases and injuries that led to ...
TY - JOUR. T1 - Simultaneous infusion of nitroglycerin and nitroprusside to offset adverse effects of vasopressin during portosystemic shunting. AU - Sirinek, Kenneth R.. AU - Adcock, Deborah K.. AU - Levine, Barry A.. PY - 1989/1. Y1 - 1989/1. N2 - In the present study, 52 patients with cirrhosis, portal hypertension, and variceal hemorrhage underwent either an elective or an emergency side-to-side portacaval shunt operation. Vasopressin was infused intravenously at 60 units/hour from just prior to abdominal incision until completion of the anastomosis. Eight of 35 patients who received vasopressin alone (23 percent) tolerated increased doses of 75 to 90 units/hour to obtain hemostasis. Four of 52 patients required simultaneous infusion of sodium nitroprusside to correct systemic hypertension. An additional 15 percent reduction in portal venous pressure occurred in these patients. Eleven of 13 patients with vasopressin-induced myocardial ischemia responded to simultaneous infusion of ...
TY - JOUR. T1 - Renal Failure Limiting Antihypertensive Therapy as an Indication for Renal Revascularization. T2 - A Case Report. AU - Textor, Stephen C.. AU - Novick, Andrew C.. AU - Steinmuller, Donald R.. AU - Streem, Stevan B.. PY - 1983/11. Y1 - 1983/11. N2 - Although surgical repair of renal artery stenosis occasionally improves renal function, it is not yet known when revascularization is indicated for that reason. We report the results observed in a patient with renovascular hypertension and additional stenosis in the contralateral kidney whose renal function deteriorated on repeated occasions during antihypertensive therapy. Renal hemodynamic studies during sodium nitroprusside infusion showed severely impaired autoregulation of blood flow, and glomerular filtration rate was corrected after revascularization of the contralateral kidney alone. After surgery, normal BPs were tolerated without loss of function. These findings demonstrate a specific clinical indication for renal ...
Methods: Twenty-seven anesthetized pigs were studied during PP with insufflations to 12 mmHg by either 1/CO2, 2/ air or 3/CO2 during intravenous nitroprusside infusion (SNP) (N.=9 in each group). In 3 pigs in each group, gamma camera technique (SPECT) was used to study ventilation and perfusion distributions, in another 6 pigs an inert-gas technique (MIGET) was used for assessing ventilation-perfusion matching (VA/Q). Measurements were made during anesthesia before and after 60 minutes of PP ...
Background: Several studies have shown that both early and late effects of ischemic preconditioning (IPC) protect against myocardial injury following ischemic reperfusion. Recently, we have shown that repetition of IPC stimulus augments endothelium-dependent vasodilation in forearm circulation of healthy subjects through increases in nitric oxide (NO) production and number of endothelial progenitor cells (EPCs) under a local condition. The purpose of this study was to evaluate the late effects of IPC on endothelial function in smokers.. Methods and Results: Late phase of IPC was induced by upper limb ischemia (cuff inflation of over 200 mmHg for 5 minutes) six times a day for one month. We evaluated forearm blood flow (FBF) responses to acetylcholine (ACh) and to sodium nitroprusside (SNP) before and after IPC stimulus in 15 male smokers (27±7 yr) and 15 male non-smokers (26±5 yr). FBF was measured using a strain-gauge plethysmography. The IPC stimulus significantly increased plasma ...
The effects of nitroprusside (NP), phentolamine (PH), and nitroglycerin (NTG) were studied on systemic hemodynamics, regional contraction and epicardial ST segment in the border and non-ischemic zones of the left ventricle of anesthetized open chest dogs. The anterior descending coronary artery (LAD) was completely occluded. NP (5 microgram/Kg/min) or PH (100 microgram/Kg/min) was drip-infused, or a bolus injection of NTG (20 microgram/Kg) was administered intravenously. The 3 vasodilator agents produced somewhat similar reductions in systemic arterial pressure. However, NP caused a greater reduction in total peripheral resistance (TPR) than in left ventricular end-diastolic pressure (LVEDP), and caused a decline, in the ischemic marginal zone, in both ST segment eievation and paradoxical systolic lengthening. PH decreased TRP without reducing LVEDP and elevated the ST segment. NTG markedly reduced LVEDP and TPR slightly. NTG improved the elevated ST segment and paradoxical systolic expansion of ...
TY - JOUR. T1 - Pretreatment with low nitric oxide protects osteoblasts from high nitric oxide-induced apoptotic insults through regulation of c-Jun N-terminal kinase/c-Jun-mediated Bcl-2 gene expression and protein translocation. AU - Tai, Yu-Ting. AU - Cherng, Yih-Giun. AU - Chang, Chia Chen. AU - Hwang, Yi Ping. AU - Chen, Jui Tai. AU - Chen, Ruei-Ming. PY - 2007/5. Y1 - 2007/5. N2 - Nitric oxide (NO) can regulate osteoblast activity. In this study, we evaluated the effects of pretreatment with a low concentration of NO on osteoblast injuries induced by a high level of NO and its possible molecular mechanisms. Exposure of osteoblasts to 0.3 mM sodium nitroprusside (SNP), an NO donor, slightly increased cellular NO levels without affecting cell viability. SNP at 2 mM greatly increased the levels of cellular NO and reactive oxygen species, and induced osteoblast death. Thus, osteoblasts were treated with 0.3 and 2 mM SNP as the sources of low and high NO, respectively. Exposure of osteoblasts ...
Although we found that the vasoconstrictor response to l-NMMA was lower in blacks, we did not examine effects of other nonspecific vasoconstrictors to investigate whether this is a reflection of reduced sensitivity of the vascular smooth muscle to vasoconstrictors. However, the fact that the constrictor response to TEA was similar to whites suggests that the response to l-NMMA is specific for reduced NO bioavailability. The reduced sensitivity to exogenous NO (sodium nitroprusside) complicates the interpretation of the reduced dilator responses observed with acetylcholine and bradykinin in blacks. However, because basal NO and the contribution of NO during exercise is lower in blacks, it is likely that in addition to reduced sensitivity, there is also an endothelial defect in NO release in blacks.. l-NMMA and TEA are competitive inhibitors, and thus our results may underestimate the physiological contribution of both NO and K+Ca channels to vasodilation. Our investigation was conducted on a ...
Percent change in coronary blood flow, coronary vascular resistance and coronary epicardial diameter in response to (A) endothelium-dependent vasodilation with acetylcholine and (B) endothelium-independent vasodilation with sodium nitroprusside. (C) Percent change in coronary blood flow and coronary vascular resistance in response to adenosine. Overweight and obese subjects (BMI ≥ 25 kg/m2) in dark columns and normal weight subjects (BMI , 25kg/m2) in open columns. Results expressed as mean ± SEM. Probability values by students t-test ...
The effects of sodium nitroprusside (SNP), 3-morfolinosydnonimine (SIN-1), or S-nitroso-Nacetylpenicillamine (SNAP), on striatal dopamine release in freely moving rats, were evaluated using microdialysis 1 . When infused (1 mM) for 180 min, both SNP (n=3) and SIN-1 (n=3) increased DA dialysate concentrations (baseline levels 6.73±1.02 and 7.15±1.12 nM, respectively). The SNP-induced DA increase was inhibited by deferoxamine co-infusion, thus suggesting a key role for iron in SNP-induced increases in DA release. SNAP 1 mM 180 min infusion decreased dialysate DA (baseline levels 5.34±0.80 nM, n=3). The decrease was a consequence of SNAP-induced non-enzymatic oxidation of extracellular DA; in fact, the decrease was inhibited by N-acetyl-cysteine or uric acid co-infusion. Both SNP and SNAP greatly decreased dialysate ascorbic acid (AA, baseline values 10.82±2.5 and 8.55±2.62 μM, respectively); on the contrary, SIN-1 did not affect dialysate AA (baseline levels 7.90±0.73 μM). These finding ...
In this study we investigated to find out one of the best preparation technique by the effect of different solutions on venous morphology for harvested saphenous vein graft for CABG. Saphenous veins harvested from 10 patients were divided into three groups, and saphenous veins were divided to 3 cm segments. Group I was the control group and saphenous vein graft was enlarged by 20 mmHg, in Group II saphenous vein graft put in isotonic sodium chloride for 20 minutes and enlarged by 100 mmHg, and Group III saphenous vein graft was put in nitroprusside for 20 minutes and enlarged by 100 mmHg pressure. All saphenous vein segments were examined under light microscope for endothelial cell deprivation, intimal and medial edema and scored from 0 to 3. Mean scores were collected as datas. In nitroprusside group all scoring datas were better. As a result we found out that nitroprusside was having better protective effect on saphenous vein endothelium ...
Cyanide ion is normally found in serum; it is derived from dietary substrates and from tobacco smoke. Cyanide binds avidly (but reversibly) to ferric ion (Fe+++), most body stores of which are found in erythrocyte methemoglobin (metHgb) and in mitochondrial cytochromes. When CN- is infused or generated within the bloodstream, essentially all of it is bound to methemoglobin until intraerythrocytic methemoglobin has been saturated.. When the Fe+++ of cytochromes is bound to cyanide, the cytochromes are unable to participate in oxidative metabolism. In this situation, cells may be able to provide for their energy needs by utilizing anaerobic pathways, but they thereby generate an increasing body burden of lactic acid. Other cells may be unable to utilize these alternative pathways, and they may die hypoxic deaths.. CN- levels in packed erythrocytes are typically less than 1 μmol/L (less than 25 mcg/L); levels are roughly doubled in heavy smokers.. At healthy steady-state, most people have less ...
Fabry disease is a systematic genetic disease in which patients have abnormal blood vessels, and leads to numerous complications including cerebrovascular strokes. The objective of this study is to test the hypothesis that patients with Fabry disease have abnormal endothelial-derived vasodilation. If found to be abnormal, endothelial-derived vasodilation will serve as a useful clinical outcome measure in the evaluation of the efficacy of specific treatment of Fabry disease, and possibly of other causes of cerebrovascular stroke. The endothelium modulates vascular tone by the release of contracting and relaxing substances that act on the underlying smooth muscle. It has been previously demonstrated that patients with essential hypertension have a blunted vascular response to acetylcholine (an endothelium-dependent vasodilator). In the present study, we shall analyze the regional vascular responses to acetylcholine and sodium nitroprusside alone, and in the presence of L-NMMA (an inhibitor of the ...
OBJECTIVE: To search for determinants of endothelial dysfunction in type 2 diabetes. RESEARCH DESIGN AND METHODS: We performed a comprehensive analysis of cardiovascular risk markers and measured blood flow responses to endothelium-dependent (acetylcholine [ACh] and NG-monomethyl-L-arginine) and -independent (sodium nitroprusside [SNP]) vasoactive agents in 30 nonsmoking men with type 2 diabetes (age 51 +/- 1 years, BMI 27.8 +/- 0.4 kg/m2, HbA1c 7.4 +/- 0.3%) and 12 matched normal control men. RESULTS: ACh-induced vasodilation was 37% lower in type 2 diabetic (6.1 +/- 0.5) than in normal subjects (9.7 +/- 1.5 ml.dl-1.min-1, P , 0.01), while flows during SNP were similar (9.1 +/- 0.6 vs. 9.9 +/- 1.3 ml.dl-1.min-1, NS). The ratio of endothelium-dependent vs. -independent flow (ACh:SNP ratio) was 31% lower in type 2 diabetic (0.70 +/- 0.05) than in normal subjects (1.10 +/- 0.18, P , 0.01). Total (2.2 +/- 0.4 vs. 1.3 +/- 0.2 mmol/l, P , 0.05), VLDL, and intermediate-density lipoprotein ...
Angiotensin II (Ang II) promotes vascular disease and hypertension in part by the formation of pro-inflammatory cytokines, oxidative stress and inflammation. Signal transducer and activator of transcription 3 (STAT3) is a transcription factor known to play key roles in cytokine signaling and growth in immune cells. We tested the hypothesis that STAT3 plays an essential role in Ang II-induced vascular dysfunction and hypertension. Responses of carotid arteries from C57BL6 mice were examined in vitro after 22-hour incubation with vehicle or Ang II (10 nM) in the presence or absence of a small molecule inhibitor of STAT3 activation, S3I-201. The endothelium-dependent agonist acetylcholine (Ach) produced relaxation in arteries treated with vehicle and the response was inhibited by ~50% by Ang II (P|0.01). S3I-201 (10 πM) co-incubation prevented the Ang II-induced dysfunction. Relaxation to nitroprusside, an endothelium-independent agonist, was not altered in any group. Ang II increased vascular superoxide
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Leaders in online sourcing and delivering embryos and bulls for.I. These medical professionals funnel business to zithromax the online 20 or zithromax so pharmacies in the town that zithromax are ready to online take patients' money and dispense medication at fantastic savings. However, in vitro studies with human platelets indicate that generic sildenafil potentiates the antiaggregatory effect of zithromax 500mg generic zithromax sale generic sodium nitroprusside (a nitric oxide donor ). A reputable pharmacy or fulfillment center will zithromax require a doctor's prescription, as generic required by law. The reason it lasts longer is online because the tablet will take longer to online be broken down by your body, this means there is a bigger risk of online having more serious side effects. The pharmacokinetics of online sildenafil in patients generic with severely impaired hepatic function (Child-Pugh Class C) have not zithromax been studied. Sourcing medications from countries ...
Details: Ketone Test Strips, 100 StripsReagent Strips for Urinalysis. Test strips allow you to determine if your body is manufacturing and excreting ketones or whether consumption of exogenous ketones is effective in elevating blood ketone levels.Manufacturer: KetoSportsIngredients: Ketone (Sodium Nitroprusside) 7.1% W
The benefit of adding Sodium Nitroprusside (NPNa) or S-nitrosolutathion (GSNO) to the university of Wisconsin solution (UW) to prevent morphological alterations during cold preservation / reperfusion of rat livers ...
Initial Goal is to reduce mean arterial pressure by no more than 25% within minutes to 2 hours, then to move further downward toward 160/100 mmHg within 2-6 hours. Furosemide (Lasix) 40-80 mg IV if indicated. Na Nitroprusside (Nipride) start with 0.3- 0.5 ug/kg/min, then 1-3 ug/kg/min IV (max:,10 ug/kg/min) (50 mg in 250 ml D5W) ...
[99 Pages Report] Check for Discount on United States Vasodilator Market Report 2017 report by QYResearch Group. In this report, the United States Vasodilator market is valued...
Sodium nitroprusside. Enhanced hypotensive effect. Thyroid hormones. Effects on the heart of lofepramine may be exacerbated. ...
It can also be caused by breakdown of nitroprusside into nitric oxide and cyanide. Nitroprusside may be used during treatment ... "Sodium Nitroprusside". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. ... the medication Sodium nitroprusside, and certain seeds such as those of apples and apricots. Liquid forms of cyanide can be ...
Molsidomine and nitroprusside already contain nitrogen in the right oxidation state (+2) and liberate NO without the aid of ... Nitroprusside is used intravenously for the treatment of hypertensive crises, heart failure, and lowering of blood pressure ... Sodium nitroprusside: Monograph. Tanaka, Y.; Tang, G.; Takizawa, K.; Otsuka, K.; Eghbali, M.; Song, M.; Nishimaru, K.; ... Nitroprusside, given intravenously, acts immediately, and after stopping the infusion blood pressure returns to its previous ...
It has been associated with nitroprusside. Coronary arteriovenous fistula between coronary artery and another cardiac chamber, ...
The reagent is typically provided in two parts: A mixture of 2% sodium nitroprusside and 2% acetaldehyde in water (solution A) ... Leeuwenkamp, O. R.; van Bennekom, W. P.; van der Mark, E. J.; Bult, A. (1984). "Nitroprusside, antihypertensive drug and ... which subsequently reacts with sodium nitroprusside to the imine. Finally, the iminium salt is hydrolysed to the bright blue ...
The vasodilator most commonly used is nitroprusside.[citation needed] Individuals with chronic MR can be treated with ...
Bernshtein, V N; Belikov, V G (1961). "Sodium Nitroprusside and Its Use in Analysis". Russian Chemical Reviews. 30 (4): 227. ...
"Elevated carboxyhemoglobin associated with sodium nitroprusside treatment". Intensive Care Medicine. 31 (9): 1235-8. doi: ...
Cottrell, JE; Casthely, PA; Brodie, JD; Patel, K; Klein, A; Turndorf, H (1979). "Prevention of Nitroprusside-induced Cyanide ... Cottrell, JE; Patel, KP; Ransohoff, JR; Turndorf, H (1978). "Intracranial Pressure Changes Induced by Sodium Nitroprusside in ... Cottrell, JE; Patel, KP; Casthely, PA; Marlin, A; Turndorf, H (1981). "Cerebrospinal fluid cyanide after nitroprusside infusion ...
Sulfides also turn solutions of red sodium nitroprusside purple. Sulfites produce SO2 gas, which smells of burning sulfur, when ...
Arteriolar vasodilator Cadralazine Dihydralazine Endralazine Sodium nitroprusside "Hydralazine Hydrochloride". The American ...
Those based on sodium nitroprusside and the ruthenium sulfoxide compounds. The ruthenium sulfoxide complexes were created and ...
... s include: hydralazine minoxidil nitroprusside Messerli, F (September 2001). "Vasodilatory edema: a ...
Cyanide is produced when nitroprusside is broken down into its constituents. Rapid infusion of high-dose cyanide cause cyanide ...
Nitroprusside - an arteriolar and venous dilator, given as an intravenous infusion. Nitroprusside acts within seconds and has a ... This may be done with labetalol or sodium nitroprusside given by injection into a vein. In those who are pregnant, magnesium ... However, the potential for cyanide toxicity limits the prolonged use of nitroprusside, particularly in patients with chronic ... July 1994). "A comparison of intravenous nicardipine and sodium nitroprusside in the immediate treatment of severe hypertension ...
The most specific test is the cyanide-nitroprusside test Ultrasound/CT scan to reveal if a stone is present. Genetic analysis ... The stones may be identified by a positive nitroprusside cyanide test. The crystals are usually hexagonal, translucent, white. ...
This is done using dipsticks coated in nitroprusside or similar reagents. Nitroprusside changes from pink to purple in the ...
Among the many 3-dimensional structures Coppens characterized is the nitroprusside ion. Coppens was a pioneer in the field of X ...
Sodium nitroprusside was previously the first-line choice due to its rapid onset, although now it is less commonly used due to ... Sodium nitroprusside is also contraindicated in patients with myocardial infarction, due to coronary steal. It is again ... Hydralazine and Sodium nitroprusside are systemic vasodilators, thereby reducing afterload, however can be found to have reflex ... Sodium nitroprusside, Esmolol, Nifedipine, Minoxidil, Isradipine, and Clonidine. These medications work through a variety of ...
Among his earlier works was a treatise on nitroprussides (1868). In 1880 he published a study on the correlation between the ...
Sodium nitroprusside, a metabolite of which is thiocyanate, is however still used for the treatment of a hypertensive emergency ... Rhodanese catalyzes the reaction of sodium nitroprusside with thiosulfate to form the metabolite thiocyanate. S = C = N ⊖ ⟷ S ...
Sodium nitroprusside - Na2[Fe(CN)5NO]·2H2O. *Sodium oxide - Na2O ...
The nitroprusside anion, [Fe(CN)5NO]2−, a mixed nitrosyl cyano complex, has pharmaceutical applications as a slow release agent ... The anion in Roussin's Red Salt, [Fe2S2(NO)4]2−. The anion in Roussin's black salt, [Fe4S3(NO)7]−. The nitroprusside anion, [Fe ...
... red crystals of sodium nitroprusside can be selectively crystallized. Upon treatment with chlorine gas, potassium ferrocyanide ...
The test used in the urine test strips is based on the reaction of sodium nitroprusside (nitroferricyanide). In this reaction ... H2O Sodium nitroprusside + Acetoacetic acid + Alkali medium → Pink-magenta complex + Water The test does not measure beta- ... the acetoacetic acid in an alkali medium reacts with the sodium nitroprusside producing a magenta coloured complex: Na2[Fe(CN) ...
... nitroprusside, and electrical stimulation". Neurourology and Urodynamics. 14 (2): 153-68. doi:10.1002/nau.1930140208. PMID ...
Nitroprusside or phenylephrine may be used in those with decompensated heart failure depending on the blood pressure. Aortic ...
... tolazoline or nitroprusside. Papaverine is also being investigated as a topical growth factor in tissue expansion with some ...
"A comparison of fenoldopam with dopamine and sodium nitroprusside in patients undergoing cross-clamping of the abdominal aorta ...
Hodsman NB, Colvin JR, Kenny GN (May 1989). "Effect of ketanserin on sodium nitroprusside requirements, arterial pressure ...
Sodium nitroprusside is used in a separate urinalysis test known as the cyanide nitroprusside test or Brands test. In this ... The nitroprusside reaction is used for the identification of ketones in urine testing. Sodium nitroprusside was found to give a ... Sodium nitroprusside crystals are also of interest for optical storage. For this application, sodium nitroprusside can be ... Sodium nitroprusside is also useful in the identification the mercaptans (thiol groups) in the nitroprusside reaction. Sodium ...
For the March 6, 2017 meeting of the FDAs Pediatric Advisory Committee. Persons with disabilities having problems accessing any of the PDF files below may call 240-402-3838 for assistance. ...
A list of US medications equivalent to Sodium Nitroprusside Hydrate is available on the Drugs.com website. ... Sodium Nitroprusside Hydrate is a medicine available in a number of countries worldwide. ... Nitroprusside. Sodium Nitroprusside Hydrate (JAN) is known as Nitroprusside in the US. ... Sodium Nitroprusside Hydrate may be available in the countries listed below.. Ingredient matches for Sodium Nitroprusside ...
Learn about the potential side effects of nitroprusside. Includes common and rare side effects information for consumers and ... Applies to nitroprusside: intravenous powder for solution, intravenous solution. Along with its needed effects, nitroprusside ... Check with your doctor or nurse immediately if any of the following side effects occur while taking nitroprusside:. Less common ... and hypervolemia associated with nitroprusside. The oliguria and azotemia resolved after nitroprusside withdrawal. The patient ...
This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.. ...
SODIUM NITROPRUSSIDE (UNII: EAO03PE1TC) (NITROPRUSSIDE - UNII:169D1260KM) SODIUM NITROPRUSSIDE. 25 mg in 1 mL. ... Nitroprusside-induced hypotension will be self-limited within 1 to 10 minutes after discontinuation of the nitroprusside ... produced from about 500 mcg/kg of sodium nitroprusside. This amount of sodium nitroprusside is administered in less than an ... Sodium nitroprusside was infused at 3.9 mcg/kg/min for a total of 3.5 mg/kg over 15 hours prior to delivery of a 478 gram ...
Nitroprusside Sodium) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and ... sodium nitroprusside) Fliptop Vial for Injection. NITROPRESS® (Sodium Nitroprusside Injection) is not suitable for direct ... Nitroprusside-induced hypotension will be self-limited within 1-10 minutes after discontinuation of the nitroprusside infusion ... The mechanism of tachyphylaxis to sodium nitroprusside remains unknown.. Pediatric. The effects of sodium nitroprusside to ...
Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency. [Wikipedia] ... Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules ( ... Sodium nitroprusside is more active on veins than on arteries.. Mechanism of action. One molecule of sodium nitroprusside is ... Nitroprusside may increase the hypotensive activities of Fenoldopam.. Approved. Ferulic acid. Nitroprusside may increase the ...
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Sodium nitroprusside , C5H4FeN6Na2O3 , CID 11953895 - structure, chemical names, physical and chemical properties, ...
Sodium nitroprusside has proved to be the most effective and best-tolerated vasodilator drug available for the management of ... Successful Treatment of Neuroleptic Malignant Syndrome with Sodium Nitroprusside Annals of Internal Medicine; 104 (1): 56-57 ... Lactic Acidosis Complicating Sodium Nitroprusside Therapy Annals of Internal Medicine; 88 (1): 58-59 ... Effect of Progressive Pressure Reduction with Nitroprusside on Acute Myocardial Infarction in Humans: Determination of Optimal ...
... nitroprusside) includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. ... Generic Name: nitroprusside. *What is nitroprusside (Nitropress)?. *What are the possible side effects of nitroprusside ( ... Nitroprusside is used to treat congestive heart failure and life-threatening high blood pressure (hypertension). Nitroprusside ... Before receiving nitroprusside, tell your doctor if you have high blood pressure, kidney or liver disease, anemia (a lack of ...
... Pharmacological Interventions to Treat and Prevent Psychosis. ... Animal and human research supports that CBD and sodium nitroprusside might be effective in the prevention and treatment of ... The evidence available to date shows that CBD and sodium nitroprusside act in pathways associated with psychotic symptoms and ... and sodium nitroprusside, a nitric oxide donor, on the prevention and treatment of psychosis. ...
Intravenous fenoldopam versus sodium nitroprusside in patients with severe hypertension.. E Reisin, M M Huth, B P Nguyen, S G ... Intravenous fenoldopam versus sodium nitroprusside in patients with severe hypertension.. E Reisin, M M Huth, B P Nguyen, S G ... Intravenous fenoldopam versus sodium nitroprusside in patients with severe hypertension.. E Reisin, M M Huth, B P Nguyen, S G ... The detection of toxic levels of thiocyanate in two patients treated with nitroprusside, however, shows that fenoldopam might ...
Nitroprusside is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This ... Nitroprusside is used to treat congestive heart failure and life-threatening high blood pressure (hypertension). Nitroprusside ... Nitroprusside is injected into a vein through an infusion pump. You will receive this injection in a clinic or hospital setting ... Nitroprusside is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This ...
Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use, according to a letter to the ... The researchers found that the absolute number of patients treated with nitroprusside or isoproterenol decreased by 53 and 35 ... Nitroprusside, Isoproterenol Prescribing Drops With Price Rise. Last Updated: August 10, 2017. ... 10, 2017 (HealthDay News) -- Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use ...
Sodium nitroprusside. From Sciencemadness Wiki. Revision as of 19:26, 31 December 2020 by Mabus (Talk , contribs) (→‎Relevant ... Sodium nitroprusside or SNP is a chemical compound, often encountered as dihydrate. It is sold under the brand name Nitropress ... Sodium nitroprusside can be synthesized by digesting a solution of potassium ferrocyanide in water with nitric acid, followed ... Retrieved from "http://www.sciencemadness.org/smwiki/index.php?title=Sodium_nitroprusside&oldid=13773" ...
The effect of nitroprusside on IUD insertion experience in nulliparous women: a pilot study. Contraception. 2013 Apr;87(4):421- ... The Effect of Nitroprusside on Intrauterine Device (IUD) Insertion. This study has been completed. ... The Effect of Nitroprusside on the IUD Insertion Experience in Nulliparous Women: a Pilot Study. ... half of the subjects will receive nitroprusside gel for IUD insertion and the other half will receive a placebo gel. ...
Sodium Nitroprusside for Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, ... Sodium Nitropress Nitroprusside. *Generic Name: sodium nitroprusside for injection. *Brand Name: Sodium Nitroprusside ( ... Sodium nitroprusside is available in generic form.. What Are Side Effects of Sodium (Nitropress) Nitroprusside?. Common side ... Nitroprusside-induced hypotension will be self-limited within 1 to 10 minutes after discontinuation of the nitroprusside ...
SODIUM NITROPRUSSIDE, DIHYDRATE, ACS, Sodium Nitroprusside, Dihydrate, Sodium Nitroprusside, 0.5 g/L, Sodium Nitroprusside,.. ... Synonyms: Nitroprusside sodium; SNP; Sodium nitroprusside; Sodium pentacyanonitrosylferrate Formula: Na2[Fe(CN)5NO] · 2H2O ... FLUKA Sodium nitroprusside dihydrate Honeywell. purum p.a., ≥98.0% (AT) Synonym(s): Nitroprusside sodium; SNP; Sodium ... FLUKA Sodium nitroprusside dihydrate, purum p.a., =98.0% (AT) Honeywell. Synonyms: Nitroprusside sodium; SNP; Sodium ...
Renal effects of nitroprusside and hydralazine in patients with congestive heart failure.. J J Cogan, M H Humphreys, C J ... Nitroprusside had a more profound effect on pulmonary artery pressure, while hydralazine produced a greater elevation in ... Renal effects of nitroprusside and hydralazine in patients with congestive heart failure. ... The acute effects of nitroprusside infusion and intravenous hydralazine on renal hemodynamics and function were evaluated in ...
Lactic Acidosis Complicating Sodium Nitroprusside Therapy STEPHEN H. HUMPHREY, M.D.; DANIEL A. NASH JR., M.D., F.A.C.P. ... Sodium nitroprusside has gained acceptance in the treatment of hypertensive emergencies and low cardiac-output syndromes ... Lactic Acidosis Complicating Sodium Nitroprusside Therapy. Ann Intern Med. 1978;88:58-59. doi: 10.7326/0003-4819-88-1-58 ... We describe a case in which sodium nitroprusside therapy of uncontrolled hypertension was complicated by the development of ...
Accordingly, we compared the biological responses to infusions of ADM and nitroprusside (NP; matched for reduction of arterial ... Nitroprusside / pharmacology*. Norepinephrine / blood*. Peptides / pharmacology*. Potassium / blood. Renin-Angiotensin System ... Accordingly, we compared the biological responses to infusions of ADM and nitroprusside (NP; matched for reduction of arterial ... 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 60-27-5/Creatinine; 7440-09-7/Potassium; 85637-73-6/Atrial Natriuretic Factor ...
Contact to Sodium Nitroprusside Exporters in India, Sodium Nitroprusside Wholesalers, Sodium Nitroprusside Distributors and ... Search Indian Sodium Nitroprusside Manufacturers and Suppliers Details - ... Deals in sodium nitroprusside, Ninhydrin, Dimethylglyoxime, 1, Maleic Hydrazide, Dithizone, Guanidine Thiocyanate, Lithium ... Deals in 5 Sulfosalicylic Acid, Sodium Bismuthate, Calcium Pyruvate, Sodium Nitroprusside, Sodium Pyruvate, Ethyl Pyruvate, 3 ...
Sodium nitroprusside is a nitric oxide donor that could potentially alter MMP activity via vasodilation in vivo, but can also ... Moreover, sodium nitroprusside 3 µM was able to overcome the decrease in MMP activity that occurred with hydrogen sulfide 40 µM ... We hypothesized that hydrogen sulfide reduced activity of MMP in ex vivo bone tissue homogenates and that sodium nitroprusside ... Results: Our data showed increased MMP activity at a sodium nitroprusside concentration of 1 µM, and MMP activity increased ...
Sprawdź ile zapłacisz za lek Nitroprusside Sodium w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź ...
... such as if you can you take Sodium Nitroprusside Intravenous when you are pregnant or nursing or If Sodium Nitroprusside ... WebMD provides important information about Sodium Nitroprusside Intravenous ... What should I Know Regarding Pregnancy, Nursing and Administering Sodium Nitroprusside Vial to Children or the Elderly?. If you ...
In the second part of the study, sodium nitroprusside (SNP) was infused at doses titrated to keep mean arterial pressure ... Angiotensin II mesenteric and renal vasoregulation: dissimilar modulatory effects with nitroprusside. Broomé, Michael Umeå ... Alternatively, as the drug chosen for pressure control, sodium nitroprusside, serves as a nitric oxide donor, the relative ... Angiotensin II/blood/*pharmacology, Animals, Blood Pressure/drug effects, Female, Male, Nitroprusside/*pharmacology, Renal ...
Differential effects of diltiazem and nitroprusside on left ventricular function in experimental chronic volume overload.. C B ... Differential effects of diltiazem and nitroprusside on left ventricular function in experimental chronic volume overload. ... Differential effects of diltiazem and nitroprusside on left ventricular function in experimental chronic volume overload. ... Differential effects of diltiazem and nitroprusside on left ventricular function in experimental chronic volume overload. ...
sorbilis Mart.) on nitric oxide (NO) and other compounds generated from the degradation of sodium nitroprusside (SNP) in an ... The protective effects of guaraná extract (Paullinia cupana) on fibroblast NIH-3T3 cells exposed to sodium nitroprusside Food ... sorbilis Mart.) on nitric oxide (NO) and other compounds generated from the degradation of sodium nitroprusside (SNP) in an ...
  • Sodium nitroprusside (SNP), sold under the brand name Nitropress among others, is a medication used to lower blood pressure. (wikipedia.org)
  • What Is Sodium (Nitropress) Nitroprusside and how is it used? (rxlist.com)
  • What Are Side Effects of Sodium (Nitropress) Nitroprusside? (rxlist.com)
  • Product Information: NITROPRESS(R) injection, sodium nitroprusside injection. (rxwiki.com)
  • Nitroprusside toxicity may present as hypotension, cyanide toxicity, or thiocyanate toxicity. (drugs.com)
  • Cardiopulmonary bypass is a risk factor in the development of cyanide toxicity associated with nitroprusside. (drugs.com)
  • Hemolysis occurs as a consequence of cell injury during CPB which may make a greater amount of hemoglobin available to react with nitroprusside and this ultimately increases the risk of cyanide toxicity. (drugs.com)
  • Nitroprusside should be stopped if toxicity is suspected or documented. (drugs.com)
  • Overdosage of nitroprusside can be manifested as excessive hypotension or cyanide toxicity or as thiocyanate toxicity. (drugbank.ca)
  • Sodium nitroprusside has low toxicity. (sciencemadness.org)
  • Cyanide toxicity following nitroprusside induced hypotension. (semanticscholar.org)
  • Toxicity from sodium nitroprusside is due to the cyanide groups released from metabolism of the nitroprusside molecule, resulting in cyanide toxicity . (anesthesiageneral.com)
  • Treatment of cyanide toxicity begins with discontinuation of sodium nitroprusside administration. (anesthesiageneral.com)
  • Prevention of cyanide toxicity can be achieved by limiting the dose of sodium nitroprusside to less than 8.0 micrograms/kg/min over 1 to 3 hours. (anesthesiageneral.com)
  • Common side effects of nitroprusside include excessively low blood pressure (hypotension), cyanide toxicity, and injection site irritation. (rxwiki.com)
  • Nitroprusside can cause cyanide toxicity which can be lethal. (rxwiki.com)
  • The cyanide anion release concurrent with nitroprusside administration is associated with potential cyanide accumulation and severe toxicity. (elsevier.com)
  • Johnson CC. The actions and toxicity of sodium nitroprusside. (jamanetwork.com)
  • Lockwood A, Patka J, Rabinovich M, Wyatt K, Abraham P. Sodium nitroprusside-associated cyanide toxicity in adult patients-fact or fiction? (jamanetwork.com)
  • Sodium nitroprusside injection is not suitable for direct injection. (nih.gov)
  • 50 mg Single Dose Vial - Each 2 mL vial contains the equivalent of 50 mg sodium nitroprusside dihydrate in sterile water for injection. (nih.gov)
  • Depending on the desired concentration, the solution containing 50 mg of sodium nitroprusside must be further diluted in 250 to 1000 mL of sterile 5% dextrose injection. (rxlist.com)
  • Safe use of sodium nitroprusside injection must be guided by knowledge of the further metabolism of these products. (gnhindia.com)
  • Molecular Formula sodium nitroprusside injection is not suitable for direct injection. (medzeellifescience.com)
  • Sodium Nitroprusside Injection is supplied in amber-colored, 50 mg/2 mL Single Dose Vials (NDC 70436-028-80). (druginserts.com)
  • To protect Sodium Nitroprusside Injection from light, it should be stored in its carton until it is used. (druginserts.com)
  • Intravenous fenoldopam versus sodium nitroprusside in patients with severe hypertension. (ahajournals.org)
  • In an open-label study, we compared the efficacy and safety of intravenous infusion of fenoldopam mesylate with that of sodium nitroprusside in patients with severe hypertension or in hypertensive crisis. (ahajournals.org)
  • The acute effects of nitroprusside infusion and intravenous hydralazine on renal hemodynamics and function were evaluated in nine male patients with severe, low cardiac output, congestive heart failure (CHF). (ahajournals.org)
  • We evaluated a method of baroreflex testing involving sequential intravenous bolus injections of nitroprusside followed by phenylephrine and phenylephrine followed by nitroprusside in 18 healthy men and women, and we drew inferences regarding human sympathetic and vagal baroreflex mechanisms. (elsevier.com)
  • Sodium nitroprusside is an older intravenous vasodilator appropriate for acute hospital treatment of patients with congestive heart failure. (elsevier.com)
  • In the 24 hours after aortic repair and during resuscitation, our cardiothoracic surgeons request intravenous nitroprusside to maintain mean arterial pressure (MAP) less than 90 mm Hg to minimize bleeding at the repair. (elsevier.com)
  • For TAI patients, postoperative management included intravenous nitroprusside infusion titrated by the bedside nurse to maintain mean arterial pressure (MAP) less than 90 mm Hg during the same 24 hours. (elsevier.com)
  • 14 Herein, we compared and evaluated the effects of sodium nitroprusside and intravenous fenoldopam mesylate in an open-label, randomized, multicenter trial of patients with severe systemic hypertension. (elsevier.com)
  • Rapid Improvement of Acute Schizophrenia Symptoms After Intravenous Sodium Nitroprusside: A Randomized, Double-blind, Placebo-Controlled Trial. (jamanetwork.com)
  • Sodium nitroprusside is also indicated for producing controlled hypotension in order to reduce bleeding during surgery. (rxlist.com)
  • Sodium nitroprusside has proved to be the most effective and best-tolerated vasodilator drug available for the management of acute hypertension, heart failure, and other vasoconstricted states as well as for the induction of controlled hypotension during surgery. (annals.org)
  • Metabolic acidosis complicating sodium nitroprusside-induced hypotension has been encountered in isolated clinical experiences (2) as well as an animal study (3). (annals.org)
  • We describe a case in which sodium nitroprusside therapy of uncontrolled hypertension was complicated by the development of lactic acidosis, without hypotension. (annals.org)
  • The authors had observed that on intraoperative discontinuation of sodium nitroprusside being administered to induce hypotension, mean arterial pressure increased to above the pre-hypotension level. (ovid.com)
  • During sodium nitroprusside-induced hypotension, mean arterial pressure decreased to 49 ± 2 torr and plasma renin activity increased to 15.2 ± 0.2 ng/ml/hr. (ovid.com)
  • As the half-life of plasma renin is 15 min, the data suggest that the persistently increased plasma renin activity is probably responsible for the increase of arterial pressure following sodium nitroprusside-induced hypotension. (ovid.com)
  • A sudden death associated with the use of sodium nitroprusside for induction of hypotension during anaesthesia. (semanticscholar.org)
  • Controlled hypotension in adults undergoing choroidal melanoma resection: comparison between the efficacy of nitroprusside and magnesium sulphate. (semanticscholar.org)
  • BACKGROUND AND OBJECTIVE To determine whether magnesium sulphate could induce controlled hypotension, reduce choroidal blood flow, provide a 'dry' operative field and could be compared with sodium nitroprusside in the recently raised issue of the use of hypotensive anaesthesia in eye surgery, i.e. for choroidal tumour surgery as the choroid is the most fragile and vascular structure in the eye. (semanticscholar.org)
  • RESULTS Controlled hypotension was achieved at the target systolic pressure of 80 mmHg within 107 +/- 16 and 69 +/- 4.4 s for magnesium sulphate and sodium nitroprusside, respectively. (semanticscholar.org)
  • As a result of its breakdown to nitric oxide (NO), sodium nitroprusside has potent vasodilating effects on arterioles and venules (arterial more than venous), whereas other nitrates exhibit more selectivity for veins (e.g. nitroglycerin). (wikipedia.org)
  • Sodium nitroprusside breaks down in circulation to release nitric oxide (NO). It does this by binding to oxyhaemoglobin to release cyanide, methaemoglobin and nitric oxide. (wikipedia.org)
  • Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). (drugbank.ca)
  • Therefore, the aim is to review basic and clinical research findings from studies evaluating the effects of cannabidiol (CBD), an inhibitor of the reuptake and metabolism of anandamide and several other effects on nervous system, and sodium nitroprusside, a nitric oxide donor, on the prevention and treatment of psychosis. (greenmedinfo.com)
  • Sodium nitroprusside can be synthesized by digesting a solution of potassium ferrocyanide in water with nitric acid , followed by neutralization with sodium carbonate . (sciencemadness.org)
  • Sodium nitroprusside is a nitric oxide donor that could potentially alter MMP activity via vasodilation in vivo, but can also produce peroxynitrite, which activates MMPs by combining with superoxide. (dovepress.com)
  • Alternatively, as the drug chosen for pressure control, sodium nitroprusside, serves as a nitric oxide donor, the relative balance between nitric oxide-mediated vasodilation and Ang II-induced vasoconstriction could have regional differences. (diva-portal.org)
  • on nitric oxide (NO) and other compounds generated from the degradation of sodium nitroprusside (SNP) in an embryonic fibroblast culture (NIH-3T3 cells) were evaluated. (nih.gov)
  • Nitroprusside is a sodium or potassium salt of a molecule that includes Fe++, cyanide and nitric acid. (endocrinologyadvisor.com)
  • Sodium nitroprusside (SNP) disrupts microbial biofilms through the release of nitric oxide (NO). The actions of SNP on bacteria have been mostly limited to the genera Pseudomonas, Clostridium, and Bacillus. (figshare.com)
  • We tested the hypothesis that intracoronary infusion of the nitric oxide donor nitroprusside would increase the efficiency of adenovirus vector-mediated gene transfer to the heart. (pubfacts.com)
  • One of the most potent vasodilators i s sodium nitroprusside , which causes arteriolar and venous smooth muscle relaxation via nitric oxide-mediated mechanisms. (anesthesiageneral.com)
  • Patients with conditions associated with a higher cyanide/thiocyanate ratio (e.g. congenital (Leber's) optic atrophy, tobacco amblyopia) should only be treated with sodium nitroprusside with great caution. (wikipedia.org)
  • 12 . Sodium nitroprusside (sodium nitroferricyanide) (NTP) has potent venodilating and arteriolar-dilating properties 13 and in many respects is an ideal antihypertensive agent when rapid reduction of BP is required. (elsevier.com)
  • Sodium nitroprusside or SNP is a chemical compound, often encountered as dihydrate. (sciencemadness.org)
  • Sodium nitroprusside dihydrate reagent used for chromatographic detection of peptides containing cystine. (thomassci.com)
  • Fluka Sodium nitroprusside dihydrate puriss. (thomassci.com)
  • Sodium nitroprusside dihydrate [disodium pentacyanonitrosyl ferrate(III) dihydrate] GR for analysis ACS,Reag. (merckmillipore.com)
  • Dietary sodium intake modulates vasodilation mediated by nitroprusside but not by methacholine in the human forearm. (biomedsearch.com)
  • We conclude that under conditions of salt loading, vasodilation in response to sodium nitroprusside was enhanced, whereas the response to methacholine was not affected, suggesting a differential effect of sodium intake on endothelium-dependent and endothelium-independent responses after the administration of methacholine and sodium nitroprusside, respectively. (biomedsearch.com)
  • Nitroprusside causes peripheral vasodilation by acting directly on venous and arteriolar smooth muscle, thus reducing peripheral resistance. (medscape.com)
  • The detection of toxic levels of thiocyanate in two patients treated with nitroprusside, however, shows that fenoldopam might be preferable for the control of a hypertensive crisis or severe hypertension in patients with decreased renal function. (ahajournals.org)
  • Nitroprusside is used to treat congestive heart failure and life-threatening high blood pressure (hypertension). (everydayhealth.com)
  • Sodium nitroprusside should not be used for compensatory hypertension (e.g. due to an anteriovenous stent or coarctation of the aorta). (orange.com)
  • Nitroprusside sodium is commonly used for treating congestive heart failure and life-threatening high blood pressure (hypertension). (hellodoktor.com)
  • Renal activation of the reninangiotensin system and catecholamine release can occur with a decrease in arterial blood pressure, which can cause rebound hypertension with discontinuation of sodium nitroprusside . (anesthesiageneral.com)
  • Nitroprusside is an injectable prescription medication used to treat hypertension and congestive heart failure. (rxwiki.com)
  • Between the baseline and the end of the maintenance period, analysis of variance showed that the changes in the variables induced by fenoldopam mesylate did not differ significantly from those induced by sodium nitroprusside. (ahajournals.org)
  • In normotensive subjects, acute reduction of mean arterial pressure to 60 to 75 mm Hg by infusion of sodium nitroprusside caused a significant increase in renin activity. (nih.gov)
  • Infusion of sodium nitroprusside should therefore be started at a very low rate (0.3 mcg/kg/min), with upward titration every few minutes until the desired effect is achieved or the maximum recommended infusion rate (10 mcg/kg/min) has been reached. (rxlist.com)
  • The exogenous application of sodium nitroprusside (SNP), a NO donor, significantly alleviated the oxidative damage of salinity in seedlings of rice results may be indicate that salinity and/or SNP causes increase in activity of antioxidant enzymes, such as ascorbate peroxidase, peroxidase, H 2 O 2 and as well as leaf content of proline, chlorophyll content (chlorophyll a & chlorophyll b), Carotenoid as comparison to control. (phytojournal.com)
  • Nitroprusside-induced precipitous decreases in blood pressure can result in irreversible ischemic injuries or death. (drugs.com)
  • This study is aimed to study the effects of nitroprusside (NO donor), on the ionic currents and arrhythmogenic activity of single cardiomyocytes from the PVs. (biomedcentral.com)
  • What should I Know Regarding Pregnancy, Nursing and Administering Sodium Nitroprusside Vial to Children or the Elderly? (webmd.com)
  • Myocardial ischemia is thought to be due to a "coronary artery steal phenomenon" due to nitroprusside-induced decreased coronary vascular resistance. (drugs.com)
  • Francis, Gary S. / NITROPRUSSIDE INFUSION IN ACUTE MYOCARDIAL INFARCTION . (elsevier.com)
  • Nitroprusside exacerbates myocardial ischemia-reperfusion injury over a wide range of doses, although the mechanism does not appear to be mediated by peroxynitrite. (elsevier.com)
  • Some side effects of nitroprusside may occur that usually do not need medical attention. (drugs.com)
  • In the same study, ten renovascular-hypertensive patients given sodium nitroprusside had significant increases in renin release from the involved kidney at mean arterial pressures of 90 to 137 mm Hg. (nih.gov)
  • Their goal was to see if there was a decreased risk of POAF when patients were given sodium nitroprusside. (gregjoneslawblog.com)
  • What the researchers found was that of the patients who were analyzed and given sodium nitroprusside, 25.4 percent of them developed POAF vs. 27.9 percent of the patients in the control group. (gregjoneslawblog.com)
  • The effects of forskolin were investigated by invasive techniques using the thermodilution catheter method and compared to the beta 1-receptor agonist dobutamine and the vasodilator sodium nitroprusside in an intraindividual comparison. (nih.gov)
  • For acute reduction of arterial pressure, the potent vasodilator sodium nitroprusside is very effective. (medscape.com)
  • Sodium nitroprusside is more active on veins than on arteries, but this selectivity is much less marked than that of nitroglycerin. (nih.gov)
  • The three most common drugs employed for acute vasodilator intervention are nitroprusside, nitroglycerin, and nesiritide. (endocrinologyadvisor.com)
  • Finally, alternate agents to sodium nitroprusside include other vasodilators such as nitroglycerin and hydralazine. (anesthesiageneral.com)
  • Treatment of sodium nitroprusside overdose includes the following: Discontinuing sodium nitroprusside administration Buffering the cyanide by using sodium nitrite to convert haemoglobin to methaemoglobin as much as the patient can safely tolerate Infusing sodium thiosulfate to convert the cyanide to thiocyanate. (wikipedia.org)
  • Blood cyanide and thiocyanate concentrations produced by long-term therapy with sodium nitroprusside. (semanticscholar.org)
  • Blood cyanide (HCN) or plasma thiocyanate (SCN) concentrations, or both, were measured in 30 patients (ages 11 months-72 yr) receiving sodium nitroprusside (SNP) for 12-314 h. (semanticscholar.org)
  • 2020. https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/51549/all/nitroprusside. (unboundmedicine.com)
  • Sodium nitroprusside is also indicated for the treatment of acute congestive heart failure . (rxlist.com)
  • In the us, nipride (nitroprusside) is indicated for lowering blood pressure in cases of hypertensive crisis, for acute congestive heart failure , & for lowering blood pressure to decrease bleeding. (healthtap.com)
  • An allergy to nitroprusside could be as mild as a mild rash or as severe as difficulty breathing as well as other adverse effects. (healthtap.com)
  • Furthermore, continued administration of nitroprusside (after the initial relief of dyspnea) generally requires the placement of an arterial line and oftentimes, a pulmonary flow-directed catheter (Swan-Ganz) for optimal safe dosing. (endocrinologyadvisor.com)
  • Renal effects of nitroprusside and hydralazine in patients with congestive heart failure. (ahajournals.org)
  • Nitroprusside is a prescription medication used to treat high blood pressure (hypertention) and congestive heart failure. (rxwiki.com)
  • Additional research will refine and perhaps expand indications for nitroprusside, while parallel investigation continues to develop effective antidotes for cyanide poisoning. (elsevier.com)
  • Medications with generic name beginning with the letter 'S' (Sodium Nitroprusside). (druginserts.com)
  • Both antihypertensive medications were infused at a maximal dose increment of 0.2 microgram/kg/min (fenoldopam) and 1 microgram/kg/min (nitroprusside), with a maximal infusion rate of 1.5 micrograms/kg/min fenoldopam mesylate or 8 micrograms/kg/min sodium nitroprusside. (ahajournals.org)
  • Methacholine (0.25 to 8 micrograms/min) and sodium nitroprusside (0.25 to 8 micrograms/min) were infused intra-arterially in incremental doses, and forearm blood flow was measured. (biomedsearch.com)
  • Sodium nitroprusside is intravenously infused in cases of acute hypertensive crises. (wikipedia.org)
  • In association with the decrease in blood pressure, sodium nitroprusside administered intravenously to hypertensive and normotensive patients produces slight increases in heart rate and a variable effect on cardiac output. (nih.gov)
  • Sodium nitroprusside is indicated for the immediate reduction of blood pressure of adult and pediatric patients in hypertensive crises. (rxlist.com)
  • Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency. (drugbank.ca)
  • Sodium nitroprusside is an antihypertensive drug indicated for the immediate reduction of blood pressure of adult and pediatric patients in hypertensive crises. (rxlist.com)
  • Sodium nitroprusside has gained acceptance in the treatment of hypertensive emergencies and low cardiac-output syndromes associated with high systemic vascular resistance. (annals.org)
  • Nipride (nitroprusside) is an IV-only nitrate medicine for acute hypertensive urgency. (healthtap.com)
  • however, it seemed that a similar hemodynamic profile could be achieved by the combination of both dobutamine and sodium nitroprusside. (nih.gov)
  • After initial dosing to offer relief for severe dyspnea, continued nitroprusside administration is most effective and safest with hemodynamic monitoring with an indwelling arterial line and oftentimes a pulmonary artery flow-directed catheter. (endocrinologyadvisor.com)
  • Hemodynamic variables, the amount of sodium nitroprusside used, and blood loss were statistically analyzed. (druglib.com)
  • Hemoglobin is a biologically active substance capable of catalyzing the release of cyanide from nitroprusside. (drugs.com)
  • The products of the nitroprusside/hemoglobin reaction are cyanmethemoglobin (cyanmetHgb) and cyanide ion (CN). (gnhindia.com)
  • After gaining an electron from the iron moiety of hemoglobin, the sodium nitroprusside produces an unstable radical and methemoglobin. (anesthesiageneral.com)
  • To separate the two mechanisms, we compared the effects of dobutamine with those of sodium nitroprusside on V O 2 / D O 2 relationships in healthy volunteers. (portlandpress.com)
  • Nitroprusside metabolism involves the production of cyanide (CN), which may be extremely toxic. (drugs.com)
  • Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use, according to a letter to the editor published online Aug. 9 in the New England Journal of Medicine . (doctorslounge.com)
  • THURSDAY, Aug. 10, 2017 (HealthDay News) -- Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use, according to a letter to the editor published online Aug. 9 in the New England Journal of Medicine . (doctorslounge.com)
  • Umesh N. Khot, M.D., from the Cleveland Clinic, and colleagues examined the impact of price increases on physician prescribing for nitroprusside or isoproterenol using data from 47 hospitals in the Vizient (formerly University HealthSystem Consortium) database. (doctorslounge.com)
  • The researchers found that the absolute number of patients treated with nitroprusside or isoproterenol decreased by 53 and 35 percent, respectively, from 2012 to 2015. (doctorslounge.com)
  • Effects of sodium nitroprusside, isosorbide dinitrate, isoproterenol, phentolamine and prazosin on hepatic venous responses to sympathetic nerve stimulation in the cat. (aspetjournals.org)
  • Mice were maintained in a normothermic state or cooled to 25 degrees C. The aorta or both the pulmonary artery and aorta were clamped while a needle was advanced into the left ventricular cavity to deliver adenovirus vectors encoding enhanced green fluorescent protein (EGFP) or murine adenylyl cyclase type VI (AC(VI)) with saline, sodium nitroprusside, acetylcholine, or serotonin. (pubfacts.com)
  • Forearm blood flow was measured by venous occlusion plethysmography during dose-response studies of acetylcholine (ACh) and sodium nitroprusside (SNP) infused into the brachial artery. (diabetesjournals.org)
  • Comparative actions of adrenomedullin and nitroprusside: interactions with ANG II and norepinephrine. (biomedsearch.com)
  • Differential effects of diltiazem and nitroprusside on left ventricular function in experimental chronic volume overload. (ahajournals.org)
  • Nitroprusside reduces left ventricular diastolic pressure, left atrial pressure, pulmonary wedge pressure (pulmonary artery occlusive pressure), right atrial pressure, and pulmonary and systemic vascular resistance. (endocrinologyadvisor.com)
  • S. Akomolafe, G. Oboh, A. Akindahunsi, A. Akinyemi and O. Adeyanju, "Inhibitory Effect of Aqueous Extract of Moringa oleifera and Newbuoldia laevis Leaves on Ferrous Sulphate and Sodium Nitroprusside Induced Oxidative Stress in Rat's Testes in Vitro," Open Journal of Medicinal Chemistry , Vol. 2 No. 4, 2012, pp. 119-128. (scirp.org)
  • The present study investigated the effect of salicylic acid (SA) and sodium nitroprusside (SNP) on germination and activity of antioxidant enzymes in soybean under oxidative stress using a factorial experiment based on completely randomized design with three replications. (ac.ir)
  • In an aqueous solution infused intravenously, sodium nitroprusside is a rapid-acting vasodilator, active on both arteries and veins. (nih.gov)
  • Sodium nitroprusside produced a small decrease in basal venous tone and only large doses produced any reduction in the venous responses to hepatic nerve stimulation. (aspetjournals.org)
  • Nitroprusside increases gene transfer associated with intracoronary delivery of adenovirus. (pubfacts.com)
  • Nitroprusside is a potent vasodilating agent and increases inotropic activity of the heart. (medscape.com)
  • Cyanide accumulation is more likely in patients who are receiving nitroprusside at rates of 2 mcg/kg/min or more, but has been reported in rare cases after lesser dosages within 0.5 to 3.0 hours of infusion time. (drugs.com)
  • PATIENTS AND METHODS: A total of 60 patients undergoing bimaxillary surgery were studied in a prospective, randomized, and double-blind study of oral propranolol 10 mg or placebo as premedication before hypotensive anesthesia with sodium nitroprusside. (druglib.com)
  • We compared the resuscitation response of patients who sustained major torso trauma (MTT) and TAI with that of patients who had MTT with no TAI to determine whether nitroprasside can effectively control MAP during resuscitation and whether use of nitroprusside, because of its peripheral vasodilatory effects, is associated with a favorable resuscitation response. (elsevier.com)
  • METHODS Forty adult patients undergoing choroidal melanoma resection and anaesthetized with 2.5 mg kg(-1) propofol, followed by a constant infusion of 120 microg kg(-1) min(-1), and remifentanil 1 microg kg(-1), followed by a continuous infusion of 0.25 microg kg(-1) min(-1), were randomly assigned to two groups to receive either magnesium sulphate or sodium nitroprusside. (semanticscholar.org)
  • 2. Eight healthy volunteers received infusions of dobutamine at doses of 2, 4 and 6 μg min −1 kg −1 and nitroprusside at doses of 0.5, 1 and 2 μg min −1 kg −1 in an alternate order. (portlandpress.com)
  • Individual V O 2 / D O 2 slopes were similar with dobutamine and nitroprusside (6.5 ± 3.5 compared with 7.1 ± 4.6%, P not significant). (portlandpress.com)
  • 5. At the doses used, D O 2 and V O 2 increased more with dobutamine than with nitroprusside in healthy volunteers. (portlandpress.com)
  • Nitroprusside inhibited L-type calcium currents, transient outward currents and transient inward current, but increased delayed rectified potassium currents. (biomedcentral.com)
  • The validity of the suggested mechanism for the after reaction has been tested by the effect of potassium cyanide and sodium nitrite, which have been shown to suppress the after-effect by converting aquopentacyanoferrate to ferrocyanide and nitroprusside respectively. (ias.ac.in)
  • The aim of this study was to elucidate the vasodilating mechanism of sodium nitroprusside (SNP). (aspetjournals.org)
  • There may be other drugs that can interact with nitroprusside. (everydayhealth.com)
  • Nitroprusside sodium may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. (hellodoktor.com)
  • Nitroprusside belongs to a group of drugs called antihypertensives. (rxwiki.com)
  • In the second part of the study, sodium nitroprusside (SNP) was infused at doses titrated to keep mean arterial pressure constant, in spite of concurrent Ang II administration. (diva-portal.org)
  • Thirty minutes after discontinuation of sodium nitroprusside administration, mean arterial pressure increased to 112 ± 2 torr, which was not only higher than the prehypotension level, but also significantly higher than that recorded in the awake state. (ovid.com)
  • Gao, Y and Er, MJ (2004) Adaptive fuzzy neural control of mean arterial pressure through sodium nitroprusside infusion In: 42nd IEEE Conference on Decision and Control, 2003-12-09 - 2003-12-12, Maui, HI. (surrey.ac.uk)
  • We then contrasted least squares linear regression slopes derived from the depressor (nitroprusside) and pressor (phenylephrine) phases with 1) slopes derived from spontaneous fluctuations of systolic arterial pressures and R-R intervals, and 2) baroreflex gain derived from cross-spectral analyses of systolic pressures and R-R intervals. (elsevier.com)
  • Sodium nitroprusside has been used in clinical practice as an arterial and venous vasodilator for 40 years. (elsevier.com)
  • We recommend repeated sequential nitroprusside followed by phenylephrine doses as a simple, efficient-means to provoke and characterize human vagal and sympathetic baroreflex responses. (elsevier.com)
  • The hypotensive effect of sodium nitroprusside is seen within a minute or two after the start of an adequate infusion, and it dissipates almost as rapidly after an infusion is discontinued. (nih.gov)
  • Efficacy and safety of oral propranolol premedication to reduce reflex tachycardia during hypotensive anesthesia with sodium nitroprusside in orthognathic surgery: a double-blind randomized clinical trial. (druglib.com)
  • PURPOSE: The present study sought to determine whether premedication with oral propranolol 10 mg before hypotensive anesthesia with sodium nitroprusside could reduce reflex tachycardia, the amount of sodium nitroprusside used, and blood loss during hypotensive anesthesia for orthognathic surgery. (druglib.com)
  • CONCLUSION: Premedication with oral propranolol 10 mg before hypotensive anesthesia with sodium nitroprusside is safe and effective to reduce reflex tachycardia and the amount of sodium nitroprusside used. (druglib.com)