A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Drugs used to cause dilation of the blood vessels.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
The application of suitable drug dosage forms to the skin for either local or systemic effects.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Administration of a soluble dosage form by placement under the tongue.
A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.
The veins and arteries of the HEART.
A vasodilator with general properties similar to NITROGLYCERIN but with a more prolonged duration of action. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1025)
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC
A standard and widely accepted diagnostic test used to identify patients who have a vasodepressive and/or cardioinhibitory response as a cause of syncope. (From Braunwald, Heart Disease, 7th ed)
An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Drugs that act principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. (From Smith and Reynard, Textbook of Pharmacology, 1991, p75)
The circulation of blood through the CORONARY VESSELS of the HEART.
Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.
Inorganic salts of the hypothetical acid, H3Fe(CN)6.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
Spasm of the large- or medium-sized coronary arteries.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)
A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
Loss of consciousness due to a reduction in blood pressure that is associated with an increase in vagal tone and peripheral vasodilation.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
That phase of a muscle twitch during which a muscle returns to a resting position.
An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC
A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.
Delivery of drugs into an artery.
The flow of BLOOD through or around an organ or region of the body.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The effects, both local and systemic, caused by the bite of SCORPIONS.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
A painful linear ulcer at the margin of the anus. It appears as a crack or slit in the mucous membrane of the anus and is very painful and difficult to heal. (Dorland, 27th ed & Stedman, 25th ed)
A cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
A direct-acting vasodilator that is used as an antihypertensive agent.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
A group of organic sulfur-containing nitrites, alkyl thionitrites. S-Nitrosothiols include compounds such as S-NITROSO-N-ACETYLPENICILLAMINE and S-NITROSOGLUTATHIONE.
The main trunk of the systemic arteries.
The nonstriated involuntary muscle tissue of blood vessels.

Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation. (1/1442)

BACKGROUND: The cardiovascular complications of Marfan syndrome arise due to alterations in the structural and functional properties of fibrillin, a constituent of vascular connective tissues. Fibrillin-containing microfibrils are closely associated with arterial endothelial cells, indicating a possible functional role for fibrillin in the endothelium. Plasma concentrations of endothelial cell products are elevated in Marfan subjects, which indirectly indicates endothelial dysfunction. This study directly assessed flow- and agonist-mediated endothelium-dependent brachial artery reactivity in Marfan subjects. METHODS AND RESULTS: In 20 Marfan and 20 control subjects, brachial artery diameter, blood flow, and blood pressure were measured by ultrasonic wall tracking, Doppler ultrasound, and photoplethysmography, respectively. Measurements were taken during hand hyperemia (a stimulus for endothelium-derived nitric oxide [NO] release in the upstream brachial artery) and after sublingual administration of the endothelium-independent vasodilator nitroglycerin. In 9 Marfan and 6 control subjects, the above parameters were also assessed during intra-arterial infusions of acetylcholine and bradykinin (agonists that stimulate NO production) and NG-monomethyl-L-arginine (L-NMMA, an inhibitor of NO production). Flow-mediated responses differed markedly between Marfan and control subjects (-1.6+/-3.5% versus 6. 50+/-4.1%, respectively; P<0.0001), whereas nitroglycerin produced similar vasodilation (14.2+/-5.7% versus 15.2+/-7.8%; P=NS). Agonist-induced vasodilation to incremental intra-arterial infusions of acetylcholine and bradykinin were not significantly different between Marfan and control subjects, and intra-arterial L-NMMA produced similar reductions in brachial artery diameter in both groups. CONCLUSIONS: These data demonstrate impaired flow-mediated but preserved agonist-mediated endothelium-dependent vasodilation in Marfan subjects and suggest preservation of basal NO release. Selective loss of flow-mediated dilation suggests a role for fibrillin in endothelial cell mechanotransduction.  (+info)

Coronary vasodilator effects of BNP: mechanisms of action in coronary conductance and resistance arteries. (2/1442)

Brain natriuretic peptide (BNP), a hormone secreted predominantly in ventricular myocytes, may influence coronary vascular tone. We studied the coronary vasodilatory response to BNP under physiological conditions and after preconstriction with endothelin-1 (ET-1) in anesthetized pigs. Average peak-flow velocity (APV) was measured using intracoronary Doppler, and cross-sectional area (CSA) was measured using intravascular ultrasound. Coronary blood flow (CBF) was calculated. Intracoronary BNP induced dose-dependent increases in CSA, APV, and CBF similar in magnitude to those induced by nitroglycerin (NTG). The magnitude of BNP-induced vasodilation was accentuated after preconstriction with ET-1. Pretreatment with either the nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyl ester or the cyclooxygenase inhibitor indomethacin attenuated the coronary vasodilator effect of BNP in resistance arteries without influencing epicardial vasodilation. Pretreatment with the ATP-sensitive potassium-channel blocker glibenclamide enhanced epicardial vasodilation in response to BNP. We conclude that BNP exerts coronary vasodilator effects, predominantly in epicardial conductance vessels. An accentuated vasodilatory response to BNP occurs in ET-1-preconstricted arteries. BNP-induced vasodilation in coronary resistance arteries may be partially mediated via nitric oxide and/or prostaglandin release.  (+info)

Endothelial function is impaired in fit young adults of low birth weight. (3/1442)

OBJECTIVE: Non-insulin-dependent diabetes, hypertension and ischaemic heart disease, with insulin resistance, are associated with low birth weight (the 'Small Baby Syndrome'). Common to these adult clinical conditions is endothelial dysfunction. We tested the hypothesis that endothelial dysfunction could precede their development in those of low birth weight. METHODS: Endothelial function was measured by ultrasonic 'wall-tracking' of flow-related brachial artery dilatation in fit 19-20 year old subjects randomly selected (blind to the investigators throughout the study) from low (< 2.5 kg) and normal (3.0-3.8 kg) birth weight subjects in the 1975-7 cohort of the Cardiff Births Survey and with no known cause for endothelial dysfunction. RESULTS: Flow-related dilatation was impaired in low birth weight relative to normal birth weight subjects (median 0.04 mm [1.5%] [n = 22] cf. 0.11 mm [4.1%] [n = 17], p < 0.05; 0.04 mm [1.5%] [n = 15] cf. 0.12 mm [4.4%] [n = 12], p < 0.05 after exclusion of inadvertently included ever-smokers). CONCLUSION: The findings suggest that endothelial dysfunction is a consequence of foetal malnutrition, consistent with contributing to the clinical features of the 'Small Baby Syndrome' in later adult life.  (+info)

Transdermal nitroglycerine enhances spinal sufentanil postoperative analgesia following orthopedic surgery. (4/1442)

BACKGROUND: Sufentanil is a potent but short-acting spinal analgesic used to manage perioperative pain. This study evaluated the influence of transdermal nitroglycerine on the analgesic action of spinal sufentanil in patients undergoing orthopedic surgery. METHODS: Fifty-six patients were randomized to one of four groups. Patients were premedicated with 0.05-0.1 mg/kg intravenous midazolam and received 15 mg bupivacaine plus 2 ml of the test drug intrathecally (saline or 10 microg sufentanil). Twenty to 30 min after the spinal puncture, a transdermal patch of either 5 mg nitroglycerin or placebo was applied. The control group received spinal saline and transdermal placebo. The sufentanil group received spinal sufentanil and transdermal placebo. The nitroglycerin group received spinal saline and transdermal nitroglycerine patch. Finally, the sufentanil-nitroglycerin group received spinal sufentanil and transdermal nitroglycerine. Pain and adverse effects were evaluated using a 10-cm visual analog scale. RESULTS: The time to first rescue analgesic medication was longer for the sufentanil-nitroglycerin group (785+/-483 min) compared with the other groups (P<0.005). The time to first rescue analgesics was also longer for the sufentanil group compared with the control group (P<0.05). The sufentanil-nitroglycerin group group required less rescue analgesics in 24 h compared with the other groups (P<0.02) and had lesser 24-h pain visual analog scale scores compared with the control group (P<0.005), although these scores were similar to the sufentanil and nitroglycerin groups (P>0.05). The incidence of perioperative adverse effects was similar among groups (P>0.05). CONCLUSIONS: Transdermal nitroglycerine alone (5 mg/day), a nitric oxide generator, did not result in postoperative analgesia itself, but it prolonged the analgesic effect of spinal sufentanil (10 microg) and provided 13 h of effective postoperative analgesia after knee surgery.  (+info)

Effects of nicorandil on aortic input impedance: a comparative study with nitroglycerin. (5/1442)

A study of aortic input impedance was performed to evaluate the effects of nicorandil on the systemic circulation, and the effects were compared with those of nitroglycerin. Sixteen patients with coronary artery disease were divided into 2 age-matched groups. Aortic input impedance was obtained from Fourier analysis of aortic pressure and flow signals at baseline conditions, after intravenous administration of either 4 mg (Group 1) or 8 mg (Group 2) nicorandil, and 20 min after 0.3 mg sublingual nitroglycerin. In Group 1, the first harmonic impedance modulus (Z1, 304+/-140 dyne x s x cm(-5)) and the average of the first to third harmonics (Z1-3, 207+/-99 dyne x s x cm(-5)), indices of wave reflection, significantly decreased (24.4% (p<0.05) and 24.7% (p<0.01), respectively) after nicorandil, and 41.3% (p<0.01) and 33.9% (p<0.01) after nitroglycerin. The effects between the 2 vasodilators were not significantly different. In Group 2, Z1 and Z1-3 (275+/-138 and 196+/-93 dyne x s x cm(-5), respectively) also decreased after administration of nicorandil (28.4% (p<0.01) and 35.9% (p<0.01), respectively), and after administration of nitroglycerin (23.9% (p<0.01) and 28.7% (p<0.01), respectively), without any significant difference between the 2 drugs. Characteristic impedance and total peripheral resistance (R) in both groups remained unchanged except for R after 8 mg nicorandil (from 1830+/-415 to 1433+/-428 dyne x s x cm(-5); p<0.01). Like nitroglycerin, both doses of nicorandil reduced wave reflection. The reduction in R after 8 mg nicorandil is related to decreased tone in the resistance arteries, probably due to potassium channel opener effects.  (+info)

Does coronary artery morphology predict favorable results of intracoronary thrombolysis in patients with unstable angina pectoris? (6/1442)

The efficacy of intracoronary thrombolysis (ICT) for unstable angina pectoris (UAP) has been limited, despite the similar pathogenesis between UAP and acute myocardial infarction. To ascertain the subset of UAP suitable for ICT, the clinical responses to ICT were assessed in patients with UAP. Eighty-2 patients with medically refractory angina were divided into 2 groups according to the coronary artery morphology of the culprit lesion before ICT: (1) lesions with acute cut off and/or filling defects (AC) and (2) lesions with a tapered shape (TA). The TIMI flow grade was determined from coronary angiograms before and immediately after ICT. The diameter stenosis (%DS) and minimal lumen diameter (MLD) of the culprit lesion were determined using quantitative coronary angiographic analysis before and immediately after ICT. In addition, inhospital cardiac event rates including urgent/emergency coronary angioplasty or bypass surgery, nonfatal myocardial infarction or cardiac death were compared between the 2 groups. Multivariate logistic regression analysis was performed using 13 clinical factors contributing to successful ICT. The results showed that all 3 coronary angiographic parameters (TIMI flow, %DS, and MLD) significantly improved in the AC group (p<0.01, p<0.01 and p<0.05, respectively), whereas none of these parameters improved in the TA group. The inhospital cardiac event rate after ICT was significantly higher in the TA group (76%) than in the AC group (48%; p=0.016). Odds ratio predicting successful ICT was 7.09 (p<0.01) for the AC lesion, and 2.54 (p<0.01) for new angina. In conclusion the AC lesions are more commonly associated with coronary thrombosis that responds to ICT than are the TA lesions. Thus, the coronary angiographic morphology may be an important predictor for a successful ICT in patients with medically refractory UAP.  (+info)

Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial lipid degradation and cytochrome C release. (7/1442)

We have previously shown that nitric oxide (NO) stimulates apoptosis in different human neoplastic lymphoid cell lines through activation of caspases not only via CD95/CD95L interaction, but also independently of such death receptors. Here we investigated mitochondria-dependent mechanisms of NO-induced apoptosis in Jurkat leukemic cells. NO donor glycerol trinitrate (at the concentration, which induces apoptotic cell death) caused (1) a significant decrease in the concentration of cardiolipin, a major mitochondrial lipid; (2) a downregulation in respiratory chain complex activities; (3) a release of the mitochondrial protein cytochrome c into the cytosol; and (4) an activation of caspase-9 and caspase-3. These changes were accompanied by an increase in the number of cells with low mitochondrial transmembrane potential and with a high level of reactive oxygen species production. Higher resistance of the CD95-resistant Jurkat subclone (APO-R) cells to NO-mediated apoptosis correlated with the absence of cytochrome c release and with less alterations in other mitochondrial parameters. An inhibitor of lipid peroxidation, trolox, significantly suppressed NO-mediated apoptosis in APO-S Jurkat cells, whereas bongkrekic acid (BA), which blocks mitochondrial permeability transition, provided only a moderate antiapoptotic effect. Transfection of Jurkat cells with bcl-2 led to a complete block of apoptosis due to the prevention of changes in mitochondrial functions. We suggest that the mitochondrial damage (in particular, cardiolipin degradation and cytochrome c release) induced by NO in human leukemia cells plays a crucial role in the subsequent activation of caspase and apoptosis.  (+info)

Comparison of atenolol with propranolol in the treatment of angina pectoris with special reference to once daily administration of atenolol. (8/1442)

Fourteen patients with angina pectoris completed a double blind trial of atenolol 25 mg, 50 mg, and 100 mg twice daily and propranolol 80 mg thrice daily. In comparison with placebo, all active treatments significantly reduced anginal attacks, consumption of glyceryl trinitrate, resting and exercise heart rate, resting and exercise systolic blood pressure, and significantly prolonged exercise time. There was no significant difference between the effects of propranolol and atenolol. Nine patients completed a further trial comparing atenolol given once or twice daily. Both regimens were effective and there was no significant difference between the reductions in anginal attacks, glyceryl trinitrate consumption, systolic blood pressure, or heart rate. Twenty-four-hour ambulatory electrocardiograms showed that atenolol consistently reduced heart rate throughout the 24-hour period whether given once or twice daily. Atenolol is a potent antianginal agent which, in most patients, is likely to be effective once daily.  (+info)

Example sentences:

1. The patient experienced a spasm in their leg while running, causing them to stumble and fall.
2. The doctor diagnosed the patient with muscle spasms caused by dehydration and recommended increased fluids and stretching exercises.
3. The athlete suffered from frequent leg spasms during their training, which affected their performance and required regular massage therapy to relieve the discomfort.

Angina pectoris is a medical condition that is characterized by recurring chest pain or discomfort due to reduced blood flow and oxygen supply to the heart muscle, specifically the myocardium. It is also known as stable angina or effort angina. The symptoms of angina pectoris typically occur during physical activity or emotional stress and are relieved by rest.

The term "angina" comes from the Latin word for "strangulation," which refers to the feeling of tightness or constriction in the chest that is associated with the condition. Angina pectoris can be caused by atherosclerosis, or the buildup of plaque in the coronary arteries, which supply blood to the heart muscle. This buildup can lead to the formation of atherosclerotic plaques that can narrow the coronary arteries and reduce blood flow to the heart muscle, causing chest pain.

There are several types of angina pectoris, including:

1. Stable angina: This is the most common type of angina and is characterized by predictable and reproducible symptoms that occur during specific situations or activities, such as exercise or emotional stress.
2. Unstable angina: This type of angina is characterized by unpredictable and changing symptoms that can occur at rest or with minimal exertion. It is often a sign of a more severe underlying condition, such as a heart attack.
3. Variant angina: This type of angina occurs during physical activity, but the symptoms are not relieved by rest.
4. Prinzmetal's angina: This is a rare type of angina that occurs at rest and is characterized by a feeling of tightness or constriction in the chest.

The diagnosis of angina pectoris is typically made based on a combination of physical examination, medical history, and diagnostic tests such as electrocardiogram (ECG), stress test, and imaging studies. Treatment for angina pectoris usually involves lifestyle modifications, such as regular exercise, a healthy diet, and stress management, as well as medications to relieve symptoms and reduce the risk of complications. In some cases, surgery or other procedures may be necessary to treat the underlying condition causing the angina.

Word Origin: From coronary (pertaining to the crown) + vasospasm (a spasmodic constriction of a blood vessel).

The exact cause of vasovagal syncope is not fully understood, but it is thought to be related to an imbalance in the autonomic nervous system (which controls involuntary functions such as heart rate and blood pressure). It can be triggered by a variety of factors, including:

* Strong emotions such as fear or anxiety
* Pain or discomfort
* Intense physical activity
* Dehydration or low blood sugar
* Certain medications

During a vasovagal syncope episode, the person may experience symptoms such as:

* Dizziness or lightheadedness
* Blurred vision
* Nausea or vomiting
* Sweating
* Feeling of impending doom or loss of control
* Eventually, fainting or falling to the ground

Diagnosis of vasovagal syncope is typically made based on a combination of symptoms and physical examination findings. Tests such as an electrocardiogram (ECG) or blood tests may be ordered to rule out other conditions that may be causing the symptoms. Treatment for vasovagal syncope usually involves addressing any underlying triggers, such as managing stress or avoiding certain stimuli that may cause the episodes. In some cases, medications such as beta blockers or antidepressants may be prescribed to help regulate the heart rate and blood pressure.

Medical Definition of Scorpion Stings:

Scorpion stings are defined as the injury caused by the venomous sting of a scorpion. The venom contains a variety of compounds, including peptides, proteins, and enzymes, which can cause necrosis, inflammation, and pain. Scorpion stings can affect various parts of the body, including the skin, muscles, and organs.

Causes of Scorpion Stings:

Scorpion stings are caused by the venomous spines on the scorpion's tail. When the scorpion stings, it uses its tail to pierce the skin and inject the venom into the body. The venom can cause a range of symptoms, depending on the type of scorpion and the severity of the sting. Some common causes of scorpion stings include:

1. Scorpion bites: When a scorpion bites, it injects its venom into the body through its fangs.
2. Accidental contact: Scorpions may sting when they are disturbed or threatened, such as when someone accidentally steps on them or touches them.
3. Medical procedures: In some cases, scorpion stings may be intentionally administered as part of medical procedures, such as in the treatment of certain respiratory conditions.

Symptoms of Scorpion Stings:

The symptoms of scorpion stings can vary depending on the type of scorpion and the severity of the sting. Some common symptoms include:

1. Pain: Scorpion stings can cause severe pain, which may be felt locally at the site of the sting or more generally throughout the body.
2. Swelling: The area around the sting may become swollen and inflamed.
3. Redness: The skin around the sting may turn red and warm to the touch.
4. Itching: Some people may experience itching or a burning sensation at the site of the sting.
5. Blisters: Scorpion venom can cause blisters to form on the skin.
6. Numbness: In some cases, scorpion venom may cause numbness or tingling sensations in the face, arms, or legs.
7. Breathing difficulties: Scorpion venom can cause breathing difficulties, especially in children and people with pre-existing respiratory conditions.
8. Cardiac problems: In severe cases, scorpion venom can cause cardiac problems, such as abnormal heart rhythms or even heart failure.
9. Neurological symptoms: Some scorpion venoms can cause neurological symptoms, such as headaches, dizziness, and confusion.
10. Seizures: In rare cases, scorpion stings may cause seizures.

Treatment of Scorpion Sting

If you suspect that you or someone else has been stung by a scorpion, seek medical attention immediately. Here are some general treatment guidelines:

1. Remain calm: Try to remain as calm as possible and do not panic.
2. Remove the stinger: Gently remove the stinger from the skin using tweezers or a credit card. Avoid squeezing the stinger, as this can release more venom.
3. Clean the wound: Wash the wound with soap and water to prevent infection.
4. Apply ice: Apply an ice pack or cold compress to reduce swelling and pain.
5. Elevate the affected area: Elevate the limb or area where the sting occurred to reduce swelling.
6. Take antihistamines: Antihistamines, such as Benadryl, can help reduce itching and inflammation.
7. Use pain relief medication: Over-the-counter pain relief medication, such as acetaminophen or ibuprofen, can help relieve pain and discomfort.
8. Monitor for signs of infection: Monitor the wound for signs of infection, such as redness, swelling, increased pain, or pus. If you notice any of these symptoms, seek medical attention immediately.
9. Seek medical attention: If you experience any of the following symptoms, seek medical attention immediately:
* Difficulty breathing
* Rapid heartbeat
* Nausea and vomiting
* Abdominal pain
* Fever
* Confusion or disorientation

It is important to note that some scorpion stings can cause severe reactions, and in rare cases, can be fatal. If you suspect that you or someone else has been stung by a dangerous scorpion, do not hesitate to seek medical attention immediately.

Coronary disease is often caused by a combination of genetic and lifestyle factors, such as high blood pressure, high cholesterol levels, smoking, obesity, and a lack of physical activity. It can also be triggered by other medical conditions, such as diabetes and kidney disease.

The symptoms of coronary disease can vary depending on the severity of the condition, but may include:

* Chest pain or discomfort (angina)
* Shortness of breath
* Fatigue
* Swelling of the legs and feet
* Pain in the arms and back

Coronary disease is typically diagnosed through a combination of physical examination, medical history, and diagnostic tests such as electrocardiograms (ECGs), stress tests, and cardiac imaging. Treatment for coronary disease may include lifestyle changes, medications to control symptoms, and surgical procedures such as angioplasty or bypass surgery to improve blood flow to the heart.

Preventative measures for coronary disease include:

* Maintaining a healthy diet and exercise routine
* Quitting smoking and limiting alcohol consumption
* Managing high blood pressure, high cholesterol levels, and other underlying medical conditions
* Reducing stress through relaxation techniques or therapy.

* Pain during bowel movements
* Bleeding during bowel movements
* Itching or burning sensation around the anus
* Discharge of pus from the anus
* Redness and swelling around the anus

Fissure in ano can be caused by straining during bowel movements, constipation, diarrhea, or any other condition that puts pressure on the anal skin. Treatment for fissure in ano includes:

* Increasing fiber intake to soften stools and reduce constipation
* Drinking plenty of water to keep the stools soft
* Avoiding straining during bowel movements
* Using stool softeners or laxatives if necessary
* Applying a topical cream or ointment to reduce pain and promote healing
* In some cases, prescription medications may be used to treat fissure in ano.

It is important to seek medical attention if you experience any symptoms of fissure in ano, as it can lead to complications such as infection or narrowing of the anus if left untreated. A healthcare professional can diagnose fissure in ano by examining the anus and performing a physical rectal examination.

In addition to medical treatment, there are some self-care measures that can help manage symptoms of fissure in ano, such as:

* Soaking in a warm bath for 10-15 minutes several times a day to reduce pain and promote healing
* Applying a cold compress or ice pack to the affected area to reduce pain and swelling
* Avoiding spicy or irritating foods and drinks
* Using stool softeners or laxatives as directed by a healthcare professional.

It is important to note that fissure in ano can be a recurring condition, so it is important to take steps to prevent recurrence, such as maintaining a high fiber diet and drinking plenty of fluids.

Some forms of nitroglycerin last much longer in the body than others. Nitroglycerin as well as the onset and duration of action ... Nitroglycerin was also used as an ingredient in military propellants for use in firearms. Nitroglycerin has been used in ... Nitroglycerin and any diluents can deflagrate (burn). The explosive power of nitroglycerin derives from detonation: energy from ... "Nitroglycerin". Ogbru, Omudhome. "nitroglycerin, Nitro-Bid: Drug Facts, Side Effects and Dosing". MedicineNet. Kaplan, K. J.; ...
The drug nitroglycerin (GTN) is a dilute form of the same chemical used as the explosive, nitroglycerin. Dilution makes it non- ... 4 (1): 3-5. Note: Hering renamed nitroglycerine "glonoine". Fye WB (January 1986). "Nitroglycerin: a homeopathic remedy". ... Nitroglycerin is in the nitrate family of medications. While it is not entirely clear how it works, it is believed to function ... Nitroglycerin was written about as early as 1846 and came into medical use in 1878. It is on the World Health Organization's ...
... leading to a complete ban on the transport of liquid nitroglycerin in California. Liquid nitroglycerin was widely banned ... He was successful in mixing nitroglycerine with Kieselgur which made it less sensitive to shocks. In October 1867, Nobel filed ... After the death of his younger brother Emil in an 1864 nitroglycerin explosion at the family's armaments factory in Heleneborg ... "Nitroglycerin . Transcontinental Railroad . WGBH American Experience - PBS". pbs.org. Retrieved 22 August 2015. "Alfred Nobel ...
ISBN 978-1-58348-428-9.[page needed] Fye WB (1986). "Nitroglycerin: a homeopathic remedy". Circulation. 73 (1): 21-29. doi: ... evidence that nitroglycerin might be useful as a treatment for angina was discovered by looking through homeopathic provings, ...
That means that someone must drive the truck full of nitroglycerin, which leads to a lengthy discussion. Seagoon refuses and ... In turn, Grytpype demands their supplies, willing to take the sake if not the nitroglycerin. Seagoon and the others tip ... Seagoon announces that they should leave the nitroglycerine behind, but just then Grytpype telephones to say that they won't ... In an aside to the audience, General Yakamoto reveals that he switched the sake with the nitroglycerin. Meanwhile, Grytpype ( ...
Nitroglycerin is the most common short-acting nitrate and it is applied under the tongue. Long acting nitrates are taken 2-3 ... Typical angina is aggravated by physical activity or emotional stress and is relieved by rest or nitroglycerin. The pain may ... Todd PA, Goa KL, Langtry HD (December 1990). "Transdermal nitroglycerin (glyceryl trinitrate). A review of its pharmacology and ...
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"Nitroglycerin Sublingual: MedlinePlus Drug Information." Nitroglycerin Sublingual: MedlinePlus Drug Information. N.p., n.d. Web ... Angina pectoris, a symptom of Ischaemic heart disease, is treated with nitroglycerin. Nitroglycerin is known as a vasodilator. ... "Why Is Nitroglycerin Explosive?" General Chemistry Online: FAQ: Redox Reactions:. N.p., n.d. Web. 09 Oct. 2016. Cops, By. " ...
The stories are: The Angel in the Window to the Orient Under the Flag of Gold Concerto in O Minor for Harp and Nitroglycerin A ... Nitroglycerin evokes this violent conflict. To build this story, Pratt relied on documents and testimonies. He met Pat ...
Many private homes were built and after World War II Nitroglycerin AB gave the British architect Ralph Erskine the task to plan ... In 1915 this Gyttorps Sprängämnes AB was united with Alfred Nobel's company Nitroglycerin AB and in a few years the new company ... Erik Andrén: Nitroglycerin Aktiebolaget 1864-1964. Gyttorp 1964. Johan Johansson: Om Noraskog II. Stockholm 1881-1882. Sören ... At first gunpowder and later nitroglycerin and dynamite was produced. The explosives were mainly used for blasting in mines. ...
Lowry B, Bradfield J, Carroll R, Brewer K, Meggs W (2001). "A controlled trial of topical nitroglycerin in a New Zealand white ... Purportedly application of nitroglycerin stopped necrosis. However, one scientific animal study found no benefit in preventing ... The authors concluded the results of the study did not support the use of topical nitroglycerin in brown recluse envenoming. ... nitroglycerin, electric shock, curettage, surgical excision, and antivenom. In almost all cases, bites are self-limited and ...
Sublingual nitroglycerine is most commonly used to provide rapid relief for acute angina attacks and as a complement to anti- ... When nitroglycerine enters the bloodstream, it forms free radical nitric oxide, or NO, which activates guanylate cyclase and in ... In minor to moderate cases, nitroglycerine may be used to alleviate acute symptoms of stable angina or may be used immediately ... MedlinePlus Encyclopedia: Nitroglycerin Sublingual Ohman EM (March 2016). "CLINICAL PRACTICE. Chronic Stable Angina". The New ...
Cottrell, JE; Gupta, B; Rappaport, H; Flamm, E (1980). "Intracranial Pressure During Nitroglycerin-induced Hypotension". ...
It is also investigating the use of nitroglycerin. ACF's funding comes from a private fund, as well donations from individuals ... "Repurposing nitroglycerin for anti-cancer treatments". Medical Xpress. 27 August 2015. Retrieved 8 March 2016. www. ...
It is somewhat similar to nitroglycerin. TEGDN is often used together with trimethylolethane trinitrate (TMETN). Triethylene ... and trimethylolethane trinitrate are being considered as replacements for nitroglycerin in propellants. Triethylene glycol ...
Nitroglycerine is notorious. Old explosives are thus more dangerous (i.e. liable to be triggered to explode by very small ... Joel Davis, a former FDA expiration-date compliance chief, said that with a handful of exceptions - notably nitroglycerin, ...
"Nitro-Glycerin is Exploded in Lyons Building". The Seattle Post-Intelligencer. September 1, 1910. p. 1. "Dynamite Used in ... 6-inch deep holes had been bored into the basement wall of the elevator shaft and surrounding columns where Nitroglycerin had ...
In one case, intravenous administration of propylene glycol-suspended nitroglycerin to an elderly man may have induced coma and ... Demey, H.; Daelemans, R.; De Broe, M.E.; Bossaert, L. (1984). "Propylene glycol intoxication due to intravenous nitroglycerin ...
Nitroglycerin hadn't been discovered in Dippel's time. And although the history of the castle during Dippel's lifetime is well ... He was allegedly working with nitroglycerin, which led to the destruction of a tower at the Castle Frankenstein. But this seems ...
Nitroglycerin can be used immediately to dilate the venous system and reduce the circulating blood volume, therefore reducing ... Murrell, William (1879). "Nitroglycerin as a remedy for angina pectoris". The Lancet. 1: 80-81, 113-115, 151-152, 225-227. doi: ... In addition, nitroglycerin causes peripheral venous and artery dilation reducing cardiac preload and afterload. These ... if nitroglycerin is not administered) Being severe (at least Canadian Cardiovascular Society Classification 3) and of new onset ...
Use of intravenous nitroglycerin has been proposed. Following the procedure, a repeat CTG is performed and a repeat ultrasound ... September 2009). "Intravenous nitroglycerin for external cephalic version: a randomized controlled trial". Obstet Gynecol. 114 ...
Comparison to aprikalim (RP 52891) and nitroglycerin". The Journal of Pharmacology and Experimental Therapeutics. 259 (2): 526- ...
"KILLED BY NITRO-GLYCERINE". The New York Times. 8 September 1897. Retrieved 9 April 2022. "Awful Accident in Ohio". cdnc.ucr. ... A nitroglycerin explosion occurred in Cygnet on September 7, 1897, killing at least 6 and causing significant damage to the ...
When the torpedo was to be used, the inner tube was filled with nitroglycerin and corked; the fuse was lit and torpedo was ... Gunpowder was used in the first torpedoes, but nitroglycerin was found to work better despite its instability. The well is ... Torpedoes manufactured today use modern explosives, with the last nitroglycerin torpedo being used on May 5, 1990. Francis, Don ... Bacon and Hamor, p. 333 Michener, Carollee (April 2007). "Nitroglycerine Saved Many Wells". OIL 150. Oil City, Pennsylvania: ...
Nitroglycerin, first synthesized by Ascanio Sobrero in 1847. Nuclear reactor, the first working fission nuclear reactor was ... "The Man Who Invented Nitroglycerin Was Horrified By Dynamite". Smithsonian. Retrieved 23 October 2019. "Why do we use Italian ... "The Man Who Invented Nitroglycerin Was Horrified By Dynamite". Smithsonian. Retrieved 27 October 2019. Roeback, Tacuma. "Was ...
Chen, Z; Zhang, J; Stamler, JS (2002-06-11). "Identification of the enzymatic mechanism of nitroglycerin bioactivation". Proc ... Stamler also identified the enzymatic mechanism of nitroglycerin bioactivation and tolerance, thus solving a longstanding ... mystery (i.e., the generation of NO from nitroglycerin was awarded a Nobel Prize in 1998, but how was not understood). Stamler ...
Morgan PJ, Kung R, Tarshis J (May 2002). "Nitroglycerin as a uterine relaxant: a systematic review". Journal of Obstetrics and ... A review indicated the effectiveness of transdermal nitroglycerin. Reviews indicated magnesium supplementation seemed to be ...
Unlike Nitroglycerine, the chemical has a perfect (0) Oxygen balance, meaning that its ideal exothermic decomposition would ... It is similar to Nitroglycerin in both manufacture and properties, though it is more volatile and less viscous. ... EGDN has a slightly higher brisance than nitroglycerin. Ethylene glycol dinitrate reacts violently with potassium hydroxide, ... 2 KNO3 EGDN was used in manufacturing explosives to lower the freezing point of nitroglycerin, in order to produce dynamite for ...
Li, Jie Jack (2006). "Cardiovascular Drugs: From Nitroglycerin to Lipitor (Chapter 3)". Laughing Gas, Viagra, and Lipitor: The ... Li, Jie Jack (2006). "Cardiovascular Drugs: From Nitroglycerin to Lipitor (Chapter 3)". Laughing Gas, Viagra, and Lipitor: The ... From Nitroglycerin to Lipitor (Chapter 3)". Triumph of the Heart: The Story of Statins. Oxford, ENG: Oxford University Press. ...
Clinical Center successes include pioneering the cure of cancerous solid tumors with chemotherapy; the use of nitroglycerin to ...
The diagnostic and prognostic role of nitroglycerin-induced dilation (NID) combined with ergonovine provocation test in ... C) After IC nitroglycerine injection, the previous significant narrowing in the mid LAD is resolved. The white arrow indicates ... Comparison of coronary response to ergonovine and nitroglycerin between VSA and non-VSA groups. Bars indicate mean, and lines ... Abbreviations: MACE major adverse clinical events, VSA vasospastic angina, NID nitroglycerin induced vasodilation. ...
... - nitroglycerin capsule Carilion Materials Management. Disclaimer: This drug has not been found by FDA to be safe ... Pharmacokinetics: The volume of distribution of nitroglycerin is about 3 L/kg, and nitroglycerin is cleared from this volume at ... Hemodynamic Effects: The ill effects of nitroglycerin overdose are generally the result of nitroglycerins capacity to induce ... As tolerance to other forms of nitroglycerin develops, the effect of sublingual nitroglycerin on exercise tolerance, although ...
Nitroglycerin sublingual tablet (Nitrostat) is used to treat angina (chest pain). Learn about side effects, dosage, warnings, ... When you take nitroglycerin with certain drugs, nitroglycerin may not work as well to treat your condition. This is because the ... Highlights for nitroglycerin. *Nitroglycerin sublingual tablet is available as both a generic and a brand-name drug. Brand name ... Nitroglycerin side effects. Nitroglycerin can cause dizziness during the first few hours after you take it. You shouldnt drive ...
... and suggestions of a positive and negative effect of nitroglycerin further complicate the interpretation. ... "Clearly nitroglycerin is not a drug to go forward with after RIGHT-2, except for this intriguing finding that stroke mimic ... Cite this: RIGHT-2: Prehospital Nitroglycerin Patch Fails to Boost Stroke Outcomes - Medscape - Feb 07, 2019. ... "might be related to the specific mechanism of action of nitroglycerin and not to its blood-pressure-lowering, but this is a ...
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Nitroglycerin is a medicine that helps relax the blood vessels leading to the heart. It is used to prevent and treat chest pain ... Nitroglycerin is a medicine that helps relax the blood vessels leading to the heart. It is used to prevent and treat chest pain ... Nitroglycerin overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by ... Deaths from nitroglycerin overdose have occurred, but they are rare.. Very low blood pressure may result from taking ...
Nitroglycerin overdose Nitroglycerin is a medicine that helps relax the blood vessels leading to the heart. It is used ... as ... Nitroglycerin Topical Nitroglycerin ointment (Nitro-Bid) is used to prevent episodes of angina (chest pain) in people who have ... Nitroglycerin Spray Nitroglycerin spray is used to treat episodes of angina (chest pain) in people who have coronary artery ... Nitroglycerin Sublingual Nitroglycerin sublingual tablets are used to treat episodes of angina (chest pain) in people who have ...
Nitroglycerin (Glyceroltrinitrate) was synthetized by Ascanio Sobrero 1846 and was studied by B … ... Nitroglycerin (Glyceroltrinitrate) was synthetized by Ascanio Sobrero 1846 and was studied by Brunton, Tate, and Murrel who ... Sir William Osler was the first who suggested the use of nitroglycerin in patients with congestive heart failure "when the ... long acting nitrates isosorbide dinitrate and isosorbide 5-mononitrate now share all the beneficial effects of nitroglycerin in ...
Nitroglycerin belongs to a class of drugs known as nitrates. Angina occurs when the heart muscle is not getting enough blood. ...
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Nitroglycerine Ni tro*glyc er*ine(n[imac] tr[ o]*gl[i^]s [ e]r*[i^]n), n. [Nitro + glycerin.] (Chem.) A liquid appearing like a ... Nitroglycerin. Nitroglycerin Ni`tro*glyc"er*in, Nitroglycerine Ni`tro*glyc"er*ine(n[imac]`tr[-o]*gl[i^]s"[~e]r*[i^]n), n. [ ... nitroglycerin - [[t]na͟ɪtroʊglɪ̱sərɪn[/t]] also nitroglycerine N UNCOUNT Nitroglycerin is a liquid that is used to make ... nitroglycerin - nitroglycerine UK / US or nitroglycerin UK [ˌnaɪtrəʊˈɡlɪsərɪn] / US [ˌnaɪtroʊˈɡlɪsərɪn] noun [uncountable] ...
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Here we are some 12 years on and only a small number of people world wide are aware that Nitric Oxide, NO, is a short-lived, endogenously produced gas that acts as a signaling molecule in the body. Signal transmission by a gas, produced by one cell, which penetrates membranes and regulates the function of other cells is an entirely new principle for signaling in the human organism.. Read More ...
Nitroglycerin belongs to a class of drugs known as nitrates. Angina occurs when the heart muscle is not getting enough blood. ...
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  • Controlled trials of single oral doses of nitroglycerin have demonstrated that nitroglycerin capsules can effectively reduce exercise-related angina for up to 5 hours. (nih.gov)
  • Therapeutic doses of nitroglycerin may reduce systolic, diastolic, and mean arterial blood pressure. (nih.gov)
  • Your health care provider may have prescribed nitroglycerin tablets or spray for severe attacks. (nih.gov)
  • Canada is experiencing a shortage of nitroglycerin tablets due to an increase in demand caused by the nitroglycerin spray shortage. (canada.ca)
  • Nitroglycerin tablets are placed under the tongue and are used to treat pain during episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). (canada.ca)
  • Nitroglycerin is rapidly absorbed following sublingual administration of nitroglycerin sublingual tablets. (nih.gov)
  • The absolute bioavailability of nitroglycerin from nitroglycerin sublingual tablets is approximately 40% but tends to be variable due to factors influencing drug absorption, such as sublingual hydration and mucosal metabolism. (nih.gov)
  • 2. Nitroglycerin can be given in many routes 👍 It is available in sublingual tablets , sprays, ointments, injections, and patches. (combatmedicine101.com)
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  • In one well-controlled clinical trial, subjects receiving nitroglycerin appeared to exhibit a rebound or withdrawal effect, so that their exercise tolerance at the end of the daily drug-free interval was less than that exhibited by the parallel group receiving placebo. (nih.gov)
  • Nitroglycerin sublingual tablet is available as both a generic and a brand-name drug. (healthline.com)
  • Nitroglycerin sublingual tablet is used to stop or prevent angina (chest pain). (healthline.com)
  • Nitroglycerin sublingual tablet is a prescription drug that's available as the brand-name drug Nitrostat. (healthline.com)
  • Nitroglycerin sublingual tablet can interact with other medications, vitamins, or herbs you may be taking. (healthline.com)
  • Although nitroglycerin has historically been administered as a sublingual tablet and/or spray, it is often given intravenously in the emergency department as this enables titration to effect with predictable pharmacokinetics . (bvsalud.org)
  • How should patients take their nitroglycerin sublingual tablet? (ptceprep.com)
  • Reliable assay techniques for plasma nitroglycerin levels have only recently become available, and studies using these techniques to define the pharmacokinetics of oral nitroglycerin preparations have not been reported. (nih.gov)
  • Maximum plasma nitroglycerin concentrations (C max ) and area under the plasma concentration-time curves (AUC) increase dose-proportionally following 0.3 to 0.6 mg nitroglycerin. (nih.gov)
  • The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle and consequent dilation of peripheral arteries and veins, especially the latter. (nih.gov)
  • The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle. (nih.gov)
  • Generic nitroglycerin is used to treat angina in people with coronary artery disease. (completeonlinepharmacy.com)
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  • Nitroglycerin is used to treat angina (chest pain). (healthline.com)
  • Nitroglycerin , a fast-acting vasodilator , is commonly used as a first-line agent for angina in the emergency department and to manage chest pain due to acute coronary syndromes . (bvsalud.org)
  • Nitroglycerin also treats chest pain. (nih.gov)
  • The first products in the metabolism of nitroglycerin are inorganic nitrate, and the 1,2- and 1,3-dinitroglycerols. (nih.gov)
  • Presumably, the studied 1-week and 2-week regimens of oral nitroglycerin therapy achieved adequate nitrate-free intervals by non-uniformity of dosing interval, with longer intervals overnight. (nih.gov)
  • Nitroglycerin, an organic nitrate, is a vasodilating agent. (nih.gov)
  • Nitroglycerin, or nitrates, can make it easier for your heart to pump blood and to improve blood flow through your coronary arteries. (nih.gov)
  • The long acting nitrates isosorbide dinitrate and isosorbide 5-mononitrate now share all the beneficial effects of nitroglycerin in patients with stable and unstable angina and in selected patients with heart failure. (nih.gov)
  • Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds. (nih.gov)
  • 1. It was used as an explosive first 💣Invented in 1847, nitroglycerin has been used as an active ingredient in the manufacture of explosives , mostly dynamite , and as such it is employed in the construction , demolition , and mining industries. (combatmedicine101.com)
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  • In this review article, we outline the indications, mechanism of action, contraindications , and adverse effects of nitroglycerin as well as review relevant literature and make general recommendations regarding the use of nitroglycerin in the emergency department . (bvsalud.org)
  • Nitroglycerin forms free radical nitric oxide (NO) which activates guanylate cyclase, resulting in an increase of guanosine 3'5' monophosphate (cyclic GMP) in smooth muscle and other tissues. (nih.gov)
  • Nitroglycerin is converted to nitric oxide , a potent vasodilator , in the body, leading to venodilation at lower dosages and arteriodilation at higher dosages that results in both preload and afterload reduction, respectively. (bvsalud.org)
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  • Nitroglycerin spray is a fast-acting medication, used as needed and is typically used in addition to other medication to treat angina. (canada.ca)
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  • Nitroglycerin (Glyceroltrinitrate) was synthetized by Ascanio Sobrero 1846 and was studied by Brunton, Tate, and Murrel who published his paper on the treatment of angina pectoris in 1879. (nih.gov)
  • As noted above, careful studies with other formulations of nitroglycerin have shown that maintenance of continuous 24-hour plasma levels of nitroglycerin results in insurmountable tolerance. (nih.gov)
  • however, humans develop a tolerance to and dependence on nitroglycerin after long-term exposure. (combatmedicine101.com)
  • Sir William Osler was the first who suggested the use of nitroglycerin in patients with congestive heart failure "when the pulse is hard and firm", in his "Principles and Practice of Medicine" 1892. (nih.gov)
  • Patients have received either dexmedetomidine , magnesium sulfate or nitroglycerine. (bvsalud.org)
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  • Nitroglycerin belongs to a class of drugs called vasodilators. (healthline.com)
  • Examples of drugs that can cause interactions with nitroglycerin are listed below. (healthline.com)
  • Taking any of these drugs with nitroglycerin can cause very low blood pressure. (healthline.com)
  • Very low blood pressure may result from taking nitroglycerin with other medicines whose action also lowers blood pressure, such as drugs used to treat erectile dysfunction. (medlineplus.gov)
  • may get heparin (or another blood thinner) and nitroglycerin (under the tongue or through an IV). (nih.gov)
  • Elevated central venous and pulmonary capillary wedge pressures, and pulmonary and systemic vascular resistance are also reduced by nitroglycerin therapy. (nih.gov)
  • Nitroglycerin is a medicine that helps relax the blood vessels leading to the heart. (medlineplus.gov)
  • 4. The man who created it as an explosive, was given it for his heart 💕 a A few months before his death in 1896, Alfred Nobel (the founder of nitroglycerin as a commercially useful explosive) was prescribed nitroglycerin for this heart condition, writing to a friend: "Isn't it the irony of fate that I have been prescribed nitro-glycerin, to be taken internally! (combatmedicine101.com)
  • The aim of the current study was to compare magnesium sulphate and dexmedetomidine with nitroglycerin as regard hypotensive effect as primary outcome, volume of blood loss, blood substitution and pattern of recovery as secondary outcome during lumbar spine surgery . (bvsalud.org)
  • 0.000) with duration of surgery between different study groups with duration of surgery shortest in dexmedetomidine group followed by magnesium sulfate group and then nitroglycerine group. (bvsalud.org)
  • There were highly significant differences between different study groups with fluid maintenance with higher volume in nitroglycerine group then magnesium sulfate group and then dexmedetomidine group. (bvsalud.org)
  • 0.000) with systolic blood pressure between study groups at A1 and hypotensive agent discontinuation with lowest systolic blood pressure in dexmedetomidine group followed by magnesium sulfate group and then nitroglycerine group. (bvsalud.org)
  • Medicines with other names may also contain nitroglycerin. (medlineplus.gov)
  • An overnight hospital stay may be needed if a long-acting nitroglycerine drug preparation caused the overdose. (medlineplus.gov)
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  • Nitroglycerin - This article is about the chemical properties of nitroglycerin and its use as an explosive. (en-academic.com)
  • Nitroglycerin can cause dizziness during the first few hours after you take it. (healthline.com)
  • Mean peak nitroglycerin plasma concentrations occur at a mean time of approximately 6 to 7 minutes postdose (Table 1). (nih.gov)
  • Below are symptoms of a nitroglycerin overdose in different parts of the body. (medlineplus.gov)
  • The volume of distribution of nitroglycerin is about 3 L/kg, and nitroglycerin is cleared from this volume at extremely rapid rates, with a resulting serum half-life of about 3 minutes. (nih.gov)
  • Nitroglycerin overdose occurs when someone takes more than the normal or recommended amount of this medicine. (medlineplus.gov)
  • Canada is experiencing a shortage of nitroglycerin 0.4 MG/ACT sprays due to supply issues with the raw materials used to make the sprays as well as an increase in demand. (canada.ca)
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  • Nitroglycerin is in a class of medications called vasodilators. (nih.gov)
  • Includes nitroglycerin retail price, life-threatening side effects on women for you solve your reservation. (kidspressmagazine.com)
  • with rest or within 3 minutes of taking nitroglycerin , call for emergency medical help. (nih.gov)