A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Drugs used to cause dilation of the blood vessels.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
The application of suitable drug dosage forms to the skin for either local or systemic effects.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Administration of a soluble dosage form by placement under the tongue.
A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.
The veins and arteries of the HEART.
A vasodilator with general properties similar to NITROGLYCERIN but with a more prolonged duration of action. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1025)
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.
A standard and widely accepted diagnostic test used to identify patients who have a vasodepressive and/or cardioinhibitory response as a cause of syncope. (From Braunwald, Heart Disease, 7th ed)
An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Drugs that act principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. (From Smith and Reynard, Textbook of Pharmacology, 1991, p75)
The circulation of blood through the CORONARY VESSELS of the HEART.
Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.
Inorganic salts of the hypothetical acid, H3Fe(CN)6.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
Spasm of the large- or medium-sized coronary arteries.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)
A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
Loss of consciousness due to a reduction in blood pressure that is associated with an increase in vagal tone and peripheral vasodilation.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
That phase of a muscle twitch during which a muscle returns to a resting position.
An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.
A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.
Delivery of drugs into an artery.
The flow of BLOOD through or around an organ or region of the body.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The effects, both local and systemic, caused by the bite of SCORPIONS.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
A painful linear ulcer at the margin of the anus. It appears as a crack or slit in the mucous membrane of the anus and is very painful and difficult to heal. (Dorland, 27th ed & Stedman, 25th ed)
A cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
A direct-acting vasodilator that is used as an antihypertensive agent.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
A group of organic sulfur-containing nitrites, alkyl thionitrites. S-Nitrosothiols include compounds such as S-NITROSO-N-ACETYLPENICILLAMINE and S-NITROSOGLUTATHIONE.
The main trunk of the systemic arteries.
The nonstriated involuntary muscle tissue of blood vessels.

Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation. (1/1442)

BACKGROUND: The cardiovascular complications of Marfan syndrome arise due to alterations in the structural and functional properties of fibrillin, a constituent of vascular connective tissues. Fibrillin-containing microfibrils are closely associated with arterial endothelial cells, indicating a possible functional role for fibrillin in the endothelium. Plasma concentrations of endothelial cell products are elevated in Marfan subjects, which indirectly indicates endothelial dysfunction. This study directly assessed flow- and agonist-mediated endothelium-dependent brachial artery reactivity in Marfan subjects. METHODS AND RESULTS: In 20 Marfan and 20 control subjects, brachial artery diameter, blood flow, and blood pressure were measured by ultrasonic wall tracking, Doppler ultrasound, and photoplethysmography, respectively. Measurements were taken during hand hyperemia (a stimulus for endothelium-derived nitric oxide [NO] release in the upstream brachial artery) and after sublingual administration of the endothelium-independent vasodilator nitroglycerin. In 9 Marfan and 6 control subjects, the above parameters were also assessed during intra-arterial infusions of acetylcholine and bradykinin (agonists that stimulate NO production) and NG-monomethyl-L-arginine (L-NMMA, an inhibitor of NO production). Flow-mediated responses differed markedly between Marfan and control subjects (-1.6+/-3.5% versus 6. 50+/-4.1%, respectively; P<0.0001), whereas nitroglycerin produced similar vasodilation (14.2+/-5.7% versus 15.2+/-7.8%; P=NS). Agonist-induced vasodilation to incremental intra-arterial infusions of acetylcholine and bradykinin were not significantly different between Marfan and control subjects, and intra-arterial L-NMMA produced similar reductions in brachial artery diameter in both groups. CONCLUSIONS: These data demonstrate impaired flow-mediated but preserved agonist-mediated endothelium-dependent vasodilation in Marfan subjects and suggest preservation of basal NO release. Selective loss of flow-mediated dilation suggests a role for fibrillin in endothelial cell mechanotransduction.  (+info)

Coronary vasodilator effects of BNP: mechanisms of action in coronary conductance and resistance arteries. (2/1442)

Brain natriuretic peptide (BNP), a hormone secreted predominantly in ventricular myocytes, may influence coronary vascular tone. We studied the coronary vasodilatory response to BNP under physiological conditions and after preconstriction with endothelin-1 (ET-1) in anesthetized pigs. Average peak-flow velocity (APV) was measured using intracoronary Doppler, and cross-sectional area (CSA) was measured using intravascular ultrasound. Coronary blood flow (CBF) was calculated. Intracoronary BNP induced dose-dependent increases in CSA, APV, and CBF similar in magnitude to those induced by nitroglycerin (NTG). The magnitude of BNP-induced vasodilation was accentuated after preconstriction with ET-1. Pretreatment with either the nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyl ester or the cyclooxygenase inhibitor indomethacin attenuated the coronary vasodilator effect of BNP in resistance arteries without influencing epicardial vasodilation. Pretreatment with the ATP-sensitive potassium-channel blocker glibenclamide enhanced epicardial vasodilation in response to BNP. We conclude that BNP exerts coronary vasodilator effects, predominantly in epicardial conductance vessels. An accentuated vasodilatory response to BNP occurs in ET-1-preconstricted arteries. BNP-induced vasodilation in coronary resistance arteries may be partially mediated via nitric oxide and/or prostaglandin release.  (+info)

Endothelial function is impaired in fit young adults of low birth weight. (3/1442)

OBJECTIVE: Non-insulin-dependent diabetes, hypertension and ischaemic heart disease, with insulin resistance, are associated with low birth weight (the 'Small Baby Syndrome'). Common to these adult clinical conditions is endothelial dysfunction. We tested the hypothesis that endothelial dysfunction could precede their development in those of low birth weight. METHODS: Endothelial function was measured by ultrasonic 'wall-tracking' of flow-related brachial artery dilatation in fit 19-20 year old subjects randomly selected (blind to the investigators throughout the study) from low (< 2.5 kg) and normal (3.0-3.8 kg) birth weight subjects in the 1975-7 cohort of the Cardiff Births Survey and with no known cause for endothelial dysfunction. RESULTS: Flow-related dilatation was impaired in low birth weight relative to normal birth weight subjects (median 0.04 mm [1.5%] [n = 22] cf. 0.11 mm [4.1%] [n = 17], p < 0.05; 0.04 mm [1.5%] [n = 15] cf. 0.12 mm [4.4%] [n = 12], p < 0.05 after exclusion of inadvertently included ever-smokers). CONCLUSION: The findings suggest that endothelial dysfunction is a consequence of foetal malnutrition, consistent with contributing to the clinical features of the 'Small Baby Syndrome' in later adult life.  (+info)

Transdermal nitroglycerine enhances spinal sufentanil postoperative analgesia following orthopedic surgery. (4/1442)

BACKGROUND: Sufentanil is a potent but short-acting spinal analgesic used to manage perioperative pain. This study evaluated the influence of transdermal nitroglycerine on the analgesic action of spinal sufentanil in patients undergoing orthopedic surgery. METHODS: Fifty-six patients were randomized to one of four groups. Patients were premedicated with 0.05-0.1 mg/kg intravenous midazolam and received 15 mg bupivacaine plus 2 ml of the test drug intrathecally (saline or 10 microg sufentanil). Twenty to 30 min after the spinal puncture, a transdermal patch of either 5 mg nitroglycerin or placebo was applied. The control group received spinal saline and transdermal placebo. The sufentanil group received spinal sufentanil and transdermal placebo. The nitroglycerin group received spinal saline and transdermal nitroglycerine patch. Finally, the sufentanil-nitroglycerin group received spinal sufentanil and transdermal nitroglycerine. Pain and adverse effects were evaluated using a 10-cm visual analog scale. RESULTS: The time to first rescue analgesic medication was longer for the sufentanil-nitroglycerin group (785+/-483 min) compared with the other groups (P<0.005). The time to first rescue analgesics was also longer for the sufentanil group compared with the control group (P<0.05). The sufentanil-nitroglycerin group group required less rescue analgesics in 24 h compared with the other groups (P<0.02) and had lesser 24-h pain visual analog scale scores compared with the control group (P<0.005), although these scores were similar to the sufentanil and nitroglycerin groups (P>0.05). The incidence of perioperative adverse effects was similar among groups (P>0.05). CONCLUSIONS: Transdermal nitroglycerine alone (5 mg/day), a nitric oxide generator, did not result in postoperative analgesia itself, but it prolonged the analgesic effect of spinal sufentanil (10 microg) and provided 13 h of effective postoperative analgesia after knee surgery.  (+info)

Effects of nicorandil on aortic input impedance: a comparative study with nitroglycerin. (5/1442)

A study of aortic input impedance was performed to evaluate the effects of nicorandil on the systemic circulation, and the effects were compared with those of nitroglycerin. Sixteen patients with coronary artery disease were divided into 2 age-matched groups. Aortic input impedance was obtained from Fourier analysis of aortic pressure and flow signals at baseline conditions, after intravenous administration of either 4 mg (Group 1) or 8 mg (Group 2) nicorandil, and 20 min after 0.3 mg sublingual nitroglycerin. In Group 1, the first harmonic impedance modulus (Z1, 304+/-140 dyne x s x cm(-5)) and the average of the first to third harmonics (Z1-3, 207+/-99 dyne x s x cm(-5)), indices of wave reflection, significantly decreased (24.4% (p<0.05) and 24.7% (p<0.01), respectively) after nicorandil, and 41.3% (p<0.01) and 33.9% (p<0.01) after nitroglycerin. The effects between the 2 vasodilators were not significantly different. In Group 2, Z1 and Z1-3 (275+/-138 and 196+/-93 dyne x s x cm(-5), respectively) also decreased after administration of nicorandil (28.4% (p<0.01) and 35.9% (p<0.01), respectively), and after administration of nitroglycerin (23.9% (p<0.01) and 28.7% (p<0.01), respectively), without any significant difference between the 2 drugs. Characteristic impedance and total peripheral resistance (R) in both groups remained unchanged except for R after 8 mg nicorandil (from 1830+/-415 to 1433+/-428 dyne x s x cm(-5); p<0.01). Like nitroglycerin, both doses of nicorandil reduced wave reflection. The reduction in R after 8 mg nicorandil is related to decreased tone in the resistance arteries, probably due to potassium channel opener effects.  (+info)

Does coronary artery morphology predict favorable results of intracoronary thrombolysis in patients with unstable angina pectoris? (6/1442)

The efficacy of intracoronary thrombolysis (ICT) for unstable angina pectoris (UAP) has been limited, despite the similar pathogenesis between UAP and acute myocardial infarction. To ascertain the subset of UAP suitable for ICT, the clinical responses to ICT were assessed in patients with UAP. Eighty-2 patients with medically refractory angina were divided into 2 groups according to the coronary artery morphology of the culprit lesion before ICT: (1) lesions with acute cut off and/or filling defects (AC) and (2) lesions with a tapered shape (TA). The TIMI flow grade was determined from coronary angiograms before and immediately after ICT. The diameter stenosis (%DS) and minimal lumen diameter (MLD) of the culprit lesion were determined using quantitative coronary angiographic analysis before and immediately after ICT. In addition, inhospital cardiac event rates including urgent/emergency coronary angioplasty or bypass surgery, nonfatal myocardial infarction or cardiac death were compared between the 2 groups. Multivariate logistic regression analysis was performed using 13 clinical factors contributing to successful ICT. The results showed that all 3 coronary angiographic parameters (TIMI flow, %DS, and MLD) significantly improved in the AC group (p<0.01, p<0.01 and p<0.05, respectively), whereas none of these parameters improved in the TA group. The inhospital cardiac event rate after ICT was significantly higher in the TA group (76%) than in the AC group (48%; p=0.016). Odds ratio predicting successful ICT was 7.09 (p<0.01) for the AC lesion, and 2.54 (p<0.01) for new angina. In conclusion the AC lesions are more commonly associated with coronary thrombosis that responds to ICT than are the TA lesions. Thus, the coronary angiographic morphology may be an important predictor for a successful ICT in patients with medically refractory UAP.  (+info)

Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial lipid degradation and cytochrome C release. (7/1442)

We have previously shown that nitric oxide (NO) stimulates apoptosis in different human neoplastic lymphoid cell lines through activation of caspases not only via CD95/CD95L interaction, but also independently of such death receptors. Here we investigated mitochondria-dependent mechanisms of NO-induced apoptosis in Jurkat leukemic cells. NO donor glycerol trinitrate (at the concentration, which induces apoptotic cell death) caused (1) a significant decrease in the concentration of cardiolipin, a major mitochondrial lipid; (2) a downregulation in respiratory chain complex activities; (3) a release of the mitochondrial protein cytochrome c into the cytosol; and (4) an activation of caspase-9 and caspase-3. These changes were accompanied by an increase in the number of cells with low mitochondrial transmembrane potential and with a high level of reactive oxygen species production. Higher resistance of the CD95-resistant Jurkat subclone (APO-R) cells to NO-mediated apoptosis correlated with the absence of cytochrome c release and with less alterations in other mitochondrial parameters. An inhibitor of lipid peroxidation, trolox, significantly suppressed NO-mediated apoptosis in APO-S Jurkat cells, whereas bongkrekic acid (BA), which blocks mitochondrial permeability transition, provided only a moderate antiapoptotic effect. Transfection of Jurkat cells with bcl-2 led to a complete block of apoptosis due to the prevention of changes in mitochondrial functions. We suggest that the mitochondrial damage (in particular, cardiolipin degradation and cytochrome c release) induced by NO in human leukemia cells plays a crucial role in the subsequent activation of caspase and apoptosis.  (+info)

Comparison of atenolol with propranolol in the treatment of angina pectoris with special reference to once daily administration of atenolol. (8/1442)

Fourteen patients with angina pectoris completed a double blind trial of atenolol 25 mg, 50 mg, and 100 mg twice daily and propranolol 80 mg thrice daily. In comparison with placebo, all active treatments significantly reduced anginal attacks, consumption of glyceryl trinitrate, resting and exercise heart rate, resting and exercise systolic blood pressure, and significantly prolonged exercise time. There was no significant difference between the effects of propranolol and atenolol. Nine patients completed a further trial comparing atenolol given once or twice daily. Both regimens were effective and there was no significant difference between the reductions in anginal attacks, glyceryl trinitrate consumption, systolic blood pressure, or heart rate. Twenty-four-hour ambulatory electrocardiograms showed that atenolol consistently reduced heart rate throughout the 24-hour period whether given once or twice daily. Atenolol is a potent antianginal agent which, in most patients, is likely to be effective once daily.  (+info)

TY - JOUR. T1 - Importance of maintaining systemic blood pressure during nitroglycerin administration for reducing ischemic injury in patients with coronary disease. Effects on coronary blood flow, myocardial energetics and left ventricular function. AU - Miller, Richard R.. AU - Awan, Najam A.. AU - DeMaria, Anthony N.. AU - Amsterdam, Ezra A. AU - Mason, Dean T.. PY - 1977. Y1 - 1977. N2 - Because of the controversy concerning the effects on myocardial ischemia of maintaining systemic pressure concomitant with administration of nitroglycerin, this study was undertaken of the actions of nitroglycerin, with and without simultaneous phenylephrine infusion, on coronary blood flow, myocardial energetics and left ventricular function in 17 patients with multivessel coronary artery disease. Five minutes after sublingual administration of 0.4 mg of nitroglycerin, mean arterial pressure, left ventricular filling pressure, cardiac index and coronary sinus blood flow were reduced (P , 0.05) from control ...
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Appleton, Jason P. and Scutt, Polly and Dixon, Mark and Howard, Harriet and Haywood, Lee and Havard, Diane and Hepburn, Trish and England, Timothy J. and Sprigg, Nikola and Woodhouse, Lisa J. and Wardlaw, Joanna M. and Montgomery, Alan A. and Pocock, Stuart J. and Bath, Philip M.W. (2017) Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053). International Journal of Stroke . ISSN 1747-4949 ...
The major findings of this study were as follows: (1) significant vasospasm occurred in cerebral arteries on day 7, and vasospasm was attenuated after nitroglycerin administration; (2) rCBF on the right side was significantly decreased after SAH, and nitroglycerin significantly improved rCBF on the same side; (3) cGMP levels were significantly decreased in the right MCA and cerebral cortices after SAH, and nitroglycerin did not increase those cGMP levels; (4) nitroglycerin significantly increased cGMP levels in the basilar artery; and (5) cAMP levels were not affected by either SAH or nitroglycerin.. In this study, MABP was significantly decreased by nitroglycerin, but rCBF was increased. In the same primate model, the central conduction time on the clot side has been observed to remain fairly constant in MABPs above 80 mm Hg.13 The change in rCBF was found to be very small in MABPs of 80 to 100 mm Hg.13 Thus, the dosage of nitroglycerin in our study would be safe for the maintenance of rCBF and ...
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Nitroglycerin is how nitroglycerin works how to store nitroglycerin nitroglycerin mechanism nitroglycerin drug in a group of drugs called nitrates . types of nitroglycerin how does nitroglycerin work in the body nitroglycerin mg nitroglycerin under It is used to treat or prevent attacks of chest pain (angina) by relaxing the arteries and veins in the body ...
GISSI-3 is a multicentre randomised clinical trial to assess the efficacy of lisinopril, transdermal glyceryl trinitrate (GTN), and their combination in improving survival and ventricular function after acute myocardial infarction (AMI). Between June, 1991, and July, 1993, 19,394 patients were rando …
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Sublingual glyceryl trinitrate tablets or nitroglycerin spray remain the treatment of choice for rapid relief of acute symptoms and anticipated angina. Sublingual glyceryl trinitrate tablets are absorbed in the sublingual mucosa and take effect within a couple of minutes. The tablet can be discarded with resolution of chest pain to minimise adverse effects such as headache. Glyceryl trinitrate spray is equally effective and, due to its longer shelf-life, is more convenient for those with infrequent symptoms of angina. Isosorbide dinitrate undergoes hepatic conversion to mononitrate, resulting in an onset of action of 3-4 minutes. It can provide an antianginal effect for up to one hour. Less commonly it is used as a chronic antianginal drug but requires multiple dosing, and tolerance limits its usefulness. It is often used up to three times per day with a nitrate-free period of up to 14 hours to minimise tolerance. Long-acting nitrates such as oral isosorbide mononitrate or transdermal patches ...
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The purpose of this study was to investigate the effect of transdermal nitroglycerin on the survival of an ischemic one-vein flow-through venous flap (FTVF) model in the rabbit ear. Fifteen New Zealand white male rabbits were randomly divided into three groups: Group 1 (n = 5, 10 flaps)- no dressing on the operative wound; Group 2 (n = 5, 10 flaps)-occlusive film dressing group [polyurethane semipermeable membrane (Op-Site((R)))]; and Group 3 (n = 5, 10 flaps)- transdermal nitroglycerine pad (Novartis-Nitroderm TT S 5 mg) on the wound. Nitroderm TTS and the occlusive film dressing were changed daily postoperatively for 3 days. The percentage of the surviving area and the mean extent of the surviving area to the axial vein were calculated on the postoperative 14 h day. Necrotic and surviving areas of flaps were consistent with histopathologic findings. Group 3 (83 percent +/-10.46, 17.4 +/- 3.0 mm) had larger flap surviving areas and longer distances to the axial vein than Group 1 (60 percent +/- ...
The effects of the nitric oxide donor nitroglycerin on gastric emptying and antropyloroduodenal motility were evaluated in nine healthy male subjects (ages 19-36 yr). Antropyloroduodenal pressures were recorded with a manometric assembly that had nine side holes spanning the antrum and proximal duodenum and a pyloric sleeve sensor; gastric emptying was quantified scintigraphically. In each subject, the emptying of 300 ml of 25% glucose labeled with 99mTc was assessed on two separate days during intravenous infusion of either nitroglycerin (5 micrograms/min in 5% dextrose) or 5% dextrose (control). Studies were performed with the subject in the supine position; blood pressure and heart rate were monitored. Nitroglycerin had no significant effect on blood pressure or heart rate. Nitroglycerin slowed gastric emptying (P , 0.02), and this was associated with greater retention of the drink in the proximal stomach (P , 0.05). In both nitroglycerin and control studies, ingestion of the drink was ...
The aim of this study was to evaluate the impact of concurrent nitroglycerin administration on the thrombolytic efficacy of recombinant tissue-type plasminogen activator (rTPA) in patients with acute anterior myocardial infarction (AMI). Sixty patients (53 men, 7 women; mean age 54 +/- 7 years) with AMI entered the study. Thirty-three patients were randomized to receive rTPA alone (100 mg in 3 hours) (group A) and 27 to receive rTPA plus nitroglycerin (100 micrograms/min) (group B). Time from the onset of chest pain and delivery of rTPA was similar in the two groups of patients. Patients in group A had signs of reperfusion more often than the patients in group B (25 of 33 or 75.7% vs 15 of 27 or 55.5%, p less than 0.05). Time to reperfusion was also shorter in group A than in group B (19.6 +/- 9.4 minutes vs 37.8 +/- 5.9 minutes, p less than 0.05). Group B had a greater incidence of in-hospital adverse events (9 of 27 vs 5 of 33, p less than 0.05) and a higher incidence of coronary artery ...
Nitroglycerin (TNG) decreases ST-segment elevation accompanying myocardial ischemia, but its effect on morphometrically and enzymatically estimated infarct size (IS) has not been defined. Accordingly, coronary occlusion was produced in 92 conscious dogs; 65 survived for 24 hours. Thirty-three received TNG (200-300 microgram/min i.v. for 8 hours) and the results were compared with those in 32 untreated dogs. Coronary blood flow (CBF) was measured with tracer microspheres (141Ce, 85Sr and 95Nb) 5 minutes after occlusion before TNG, 20 minutes after TNG and again at 8 hours. Mean blood pressure decreased from 103 to 84 mm Hg with TNG, vs 99 to 94 mm Hg in controls (p , 0.02). Nitroglycerin increased CBF in the subendocardium of ischemic areas by 45% (0.09 to 0.13 ml/min/g). The dogs were sacrificed after 24 hours and IS was estimated morphometrically (25 +/- 1% vs 27 +/- 1% of left ventricular weight) and from myocardial CK depletion (23 +/- 1% vs 24 +/- 1%) were similar for the two groups. Thus, ...
Patient Forms nitroglycerin These occasions result in dephosphorylation of myosin gentle chains, which regulate the contractile state in smooth muscle, and result in vasodilatation. Nitroglycerin was mutagenic in Ames tests performed in 2 completely different laboratories. Nevertheless, there was no proof of mutagenicity in an in vivo dominant deadly nitroglycerin assay with male rats handled with doses up to about 363 mg/kg/day, PO, or in ex vivo cytogenetic checks in rat and canine cells. Advise the patient to read the FDA-approved patient labeling . Nitrate therapy could irritate the angina caused by hypertrophic cardiomyopathy. Nitroglycerin free next day shipping. nitroglycerin How do i buy nitroglycerin. Sweden had simply lost a warfare in opposition to Russia, and there was a determined need for army medical doctors.Furthermore, the Institute was torn by inner conflicts, and a few professors at Uppsala University beneficial closing the Institute and concentrating all medical education at ...
Get emergency medical help if you have any of these signs of an allergic reaction nitroglycerin to Allegra: hives; difficulty breathing; swelling of your face, lips, tongue, or throat . Stop taking Allegra and call your doctor if you have fever, chills, body aches, what are the side effects of nitroglycerin nitroglycerin adverse effects nitroglycerin patch side cough, or other flu symptoms ...
Efficacy of intravenous nitroglycerine in attenuation of hemodynamics to laryngoscopy and intubation-IJCA-Print ISSN No:-2394-4781 Online ISSN No:-2394-4994Article DOI No:-10.18231,Indian Journal of Clinical Anaesthesia-IP Innovative Publication Pvt Limited, Medical Journals Publication, Open Access Journals, Print J
Synonyms for nitroglycerine in Free Thesaurus. Antonyms for nitroglycerine. 5 synonyms for nitroglycerine: glyceryl trinitrate, nitroglycerin, Nitrospan, Nitrostat, trinitroglycerin. What are synonyms for nitroglycerine?
Nitroglycerin was shown to induce significant positive inotropic effect in adequate oxygen supply in isolated papillary muscles of the rat heart left ventricle. The effect depended upon inotropic reserve of the myocardium. The decrease in oxygen supply of papillary muscles inhibited their contractile activity. In these conditions, nitroglycerin exerted no positive inotropic influence on papillary muscles. Positive inotropic action of nitroglycerin became weaker after preliminary perfusion of papillary muscles with propranolol. Calcium antagonist verapamil completely abolished the positive inotropic action of nitroglycerin. The data suggest that positive inotropic action of nitroglycerin depends upon transsarcolemmal influx of calcium ions and is partially associated with the stimulation of myocardiac beta-receptors.
Absorption: In six healthy subjects, the average absolute bioavailability of nitroglycerin applied to the anal canal as a 0.2% w/w ointment was approximately 50% of the 0.75 mg nitroglycerin dose. Distribution: The volume of distribution of nitroglycerin following intravenous administration is about 3 L/kg. At plasma concentrations between 50 and 500 ng/mL, the binding of nitroglycerin to plasma proteins is approximately 60%, while that of 1,2- and 1,3-dinitroglycerin is 60% and 30%, respectively. Metabolism: Nitroglycerin is metabolized by a liver reductase enzyme to glycerol di- and mononitrate metabolites and ultimately to glycerol and organic nitrate. Known sites of extrahepatic metabolism include red blood cells and vascular walls. In addition to nitroglycerin, the two major metabolites, 1,2- and 1,3- dinitroglycerols are found in plasma. The contribution of metabolites to the relaxation of the internal anal sphincter is unknown. The dinitrates are further metabolized to nonvasoactive ...
TY - JOUR. T1 - Transdermal bioavailability and first-pass skin metabolism. T2 - A preliminary evaluation with nitroglycerin. AU - Nakashima, Emi. AU - Noonan, Patrick K.. AU - Benet, Leslie Z.. PY - 1987/8. Y1 - 1987/8. N2 - A model comprising six compartments, a systemic and presystemic compartment for nitroglycerin and each of its two dinitrate metabolites is presented to describe the interrelationships between plasma concentrations of the two metabolites and metabolism in skin after intravenous and transdermal ointment administration of nitroglycerin. Using a perfusion-limited pharmacokinetic model, the equation for the calculation of the fraction (F)of the dose of nitroglycerin systemically available from skin was derived independent of nitroglycerin plasma concentrations. Estimated F values (0.68-0.76) are comparable to values reported in Rhesus monkeys (0.80-0.84). Simulated plasma concentration-time profiles were reasonably fitted to the observed concentrations of nitroglycerin and its ...
We have demonstrated for the first time that not only the brachial artery but also retinal and intrarenal hemodynamic responses to an intravenous infusion of l-arginine are impaired in type 2 diabetic patients. Despite no significant difference in the vascular responses of the retinal and brachial arteries after the nitroglycerin administration between the patient and control groups, there were significant differences in the vascular responses of these arteries in both the normoalbuminuric and microalbuminuric patients compared with the control subjects after the l-arginine infusion, suggesting that the endothelium-dependent vascular responses in the retinal and brachial arteries are impaired but that the responsiveness of the smooth muscle to exogenous NO is not impaired in diabetic patients. On the other hand, the reduction in vascular resistance of the interlobar artery after the nitroglycerin administration was significantly lower in the microalbuminuric patients than in the control ...
Treatment of angina with nitroglycerin is more than 100 years old, but recent advances promise to revolutionize its use (1). With intravenous, long-acting transdermal and long-acting transmucosal nitroglycerin recently available, we stand on the threshold of an era of rational, effective nitroglycerin prophylaxis. To provide real benefits to patients, clinicians will have to use nitroglycerin more critically and systematically than in the past.. The basic action of nitroglycerin is relaxation of vascular smooth muscle (2). The molecular mechanism of this action remains unclear. Although calcium flux may be altered, nitroglycerin is not similar in mechanism to nifedipine, verapamil, and diltiazem ...
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Nitroglycerin is also used medically as a vasodilator to treat heart conditions, such as angina and chronic heart failure. It is one of the oldest and most useful drugs for treating heart disease by shortening or even preventing attacks of angina pectoris. Nitroglycerin comes in forms of tablets, sprays or patches. Nitroglycerin may be able to be used to help destroy prostate cancer.. Nitroglycerin is used for the treatment of angina[1], acute myocardial infarction[2], severe hypertension[citation needed], and coronary artery spasms due to cocaine[citation needed].. It is useful in decreasing angina attacks, perhaps more so than reversing angina once started, by supplementing blood concentrations of nitric oxide, also called Endothelium-derived relaxing factor, before the structure of NO as the responsible agent was known. This led to the development of transdermal patches of glyceryl trinitrate, providing 24-hour release[3]. However the effectiveness of glyceryl trinitrate is limited by ...
Nitroglycerin is also used medically as a vasodilator to treat heart conditions, such as angina and chronic heart failure. It is one of the oldest and most useful drugs for treating heart disease by shortening or even preventing attacks of angina pectoris. Nitroglycerin comes in forms of tablets, sprays or patches. Nitroglycerin may be able to be used to help destroy prostate cancer.. Nitroglycerin is used for the treatment of angina[1], acute myocardial infarction[2], severe hypertension[citation needed], and coronary artery spasms due to cocaine[citation needed].. It is useful in decreasing angina attacks, perhaps more so than reversing angina once started, by supplementing blood concentrations of nitric oxide, also called Endothelium-derived relaxing factor, before the structure of NO as the responsible agent was known. This led to the development of transdermal patches of glyceryl trinitrate, providing 24-hour release[3]. However the effectiveness of glyceryl trinitrate is limited by ...
For more than 130 years, doctors have prescribed nitroglycerin for relief of chest pain without a clear knowledge of how it actually worked. Now, not only have researchers from Howard Hughes Medical Institute (HHMI) and Duke University Medical Center solved this age-old riddle, they have also shed light on the second major mystery surrounding nitroglycerin, why patients eventually develop a tolerance to the drugs effects.. Shortly after heart patients take nitroglycerin, the blood vessels supplying the heart muscle relax, allowing oxygen-rich blood to nourish the heart and relieve the pain. While it is known that nitric oxide, a breakdown product of nitroglycerin, plays a critical role regulating blood vessel relaxation, scientists still did not know the mechanism by which nitric oxide is generated from the nitroglycerin molecule, which in fact shows little resemblance to nitric oxide.. The research team led by Jonathan Stamler, M.D., HHMI investigator at Duke, found an enzyme that not only ...
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Introduction: While nitroglycerin (NTG) is often used in the treatment of CHF it is not formally approved for that purpose. Whether addition of low dose NTG is of value in patients already on guideline-based therapy (ACE inhibitors, beta-blockers, diuretics) is not known, nor is it known whether response to NTG added to these medicines varies with severity of left ventricular dysfunction.. Methods: Exercise capacity by six-minute walk test (6MWT), quality of life by the Minnesota Living with Heart Failure Questionnaire (HFQ), and ejection duration (ED) by Sphygmocor© were measured at baseline and after a 4 week course of transdermal NTG, given at 0.2 mg/hr for 12 hours daily. We studied 45 NYHA Class II and III patients (84% male, 53.4 ± 9.1 yrs, 42% with CAD, CHF duration 3 ± 2.6 yrs, LVEF ≤40%) on stable, standard, guideline-based CHF therapy. ED was defined in msec from the foot to the incisura of the applanation tonometry derived radial artery pressure waveform.. Results: Subjects were ...
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General Approach: This study proposes to compare sublingual 0.4 mg doses of nitroglycerin to placebo for initial treatment for acute pain from suspected symptomatic cholelithiasis. Patients with right upper quadrant abdominal pain of less than 24 hour duration between ages 18 and 60 years of age will be offered treatment with sublingual nitroglycerin or placebo. Patients with obstructive hypertrophic cardiomyopathy, pronounced hypovolemia, STEMI or presumed cardiac chest pain, inferior myocardial infarction with right ventricular involvement, raised intracranial pressure, cardiac tamponade, and patients taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), pregnancy, or with a known allergy to nitroglycerin will be excluded from the study.. 2. Methods: A convenience sample of patients presenting to the Emergency Department will be randomized to receive either sublingual 0.4 mg doses of nitroglycerin or placebo. Pain prior to and at two minutes and five minutes after ...
TY - JOUR. T1 - Intracranial pressure during nitroglycerin-induced hypotension. AU - Cottrell, J. E.. AU - Gupta, B.. AU - Rappaport, H.. AU - Turndorf, H.. AU - Ransohoff, J.. AU - Flamm, E. S.. PY - 1980/1/1. Y1 - 1980/1/1. N2 - Nitroglycerin was given intravenously to 5 anesthetized, hyperventilated (PaCO2 25 to 30 torr) patients during craniotomy, to facilitate surgery by creating a relatively bloodless field, and to decrease the potential need for blood transfusion. A subarachnoid screw and an indwelling radial artery catheter were inserted to monitor intracranial pressure (ICP) and mean arterial pressure (MAP). As MAP decreased from 104.4 ± 4.0 (SE) to 69.0 ± 1.8 torr, ICP increased from 14.2 ± 0.7 (SEM) to 30.8 ± 1.1 torr. Cerebral perfusion pressure decreased from 90.2 ± 3.6 (SEM) to 38.2 ± 2.3 torr (p , 0.0005). The authors attribute this nitroglycerin-induced ICP increase to capacitance vessel dilation within the relatively noncompliant cranial cavity, with subsequent cerebral ...
Nitroglycerin is rapidly absorbed following lingual spray administration. In a pharmacokinetic study when a single 1200 mcg dose (three activations of a 400 mcg dose) of NitroMist was administered to healthy volunteers (n=12), all subjects had detectable trinitroglycerin plasma levels (mean Cmax 0.8 ± 0.7 ng/mL and tmax of 8 minutes, range 4 to 15 minutes) beginning at 2 minutes post-dose and higher levels of the 1,2- (mean Cmax 3.7 ± 1 ng/mL and tmax 34 ± 21 minutes, range 15 to 90 minutes) and 1,3-dinitroglycerin metabolites (mean Cmax 1 ± 0.3 ng/mL and mean tmax 41 ± 20 minutes, range 20 to 90 minutes). The volume of distribution of nitroglycerin following intravenous administration is 3.3 L/kg. A liver reductase enzyme is of primary importance in the metabolism of nitroglycerin to glycerol di- and mononitrate metabolites and ultimately to glycerol and organic nitrate. Known sites of extrahepatic metabolism include red blood cells and vascular walls. In addition to nitroglycerin, 2 major ...
The ill effects of nitroglycerin overdose are generally the results of nitroglycerins capacity to induce vasodilatation, venous pooling, reduced cardiac output, and hypotension. These hemodynamic changes may have protean manifestations, including increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; vertigo; palpitations; visual disturbances; nausea and vomiting (possibly with colic and even bloody diarrhea); syncope (especially in the upright posture); air hunger and dyspnea, later followed by reduced ventilatory effort; diaphoresis, with the skin either flushed or cold and clammy; heart block and bradycardia; paralysis; coma; seizures; and death.. Laboratory determinations of serum levels of nitroglycerin and its metabolites are not widely available, and such determinations have, in any event, no established role in the management of nitroglycerin overdose.. No data are available to suggest physiological maneuvers (e.g., maneuvers to ...
Nitrolingual nitroglycerin spray - Please describe the warnings of the use of nitrolingual (nitroglycerin) spray? Nitrolingual (nitroglycerin) spray. The spray form of nitroglycerine has a very rapid onset of action. It is a vasodilator so that low blood volume, fever and vasodilation, low blood pressure and stroke volume all have the potential for serious hypotension to be caused by the use of the agent.
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To study the effects of nitroglycerin on the HIF-1 pathway and P-gp regulation in cancer cells in tumor tissues, we studied the rates of immunoreactive cells regarding HIF-1α, P-gp, and VEGF in the tissues by immunohistochemical assessment in 17 patients with operable lung adenocarcinoma and angina pectoris in study A. First, we compared the rates of immunoreactive cells for HIF-1α, P-gp, and VEGF proteins in tumor tissues between the nitroglycerin and control groups before operation. Furthermore, we studied the relationship between the rate of immunoreactive cells for VEGF protein and that for HIF-1α protein and the relationship between the rate of immunoreactive cells for VEGF protein and that for P-gp protein in cancer tissues. Second, a prospective trial was designed to evaluate the effects of nitroglycerin on the plasma VEGF levels which are regulated by HIF-1 (40), and the relationship between changes in plasma VEGF levels by nitroglycerin treatment for 3 days before chemotherapy and ...
Approach to sexual disinterest personally. So it is important to the apparent disinterest that a dose of paroxetine for men with overt prostatic enlargement, the doctor then compares the information provided at school or volunteered by their awareness of pleasant sensory input. Therefore, our summary of the inducer and facilitator parasympathetic tone to the mpoa, induced signicant increases in orgasmic frequency among those who said they decided to break out of a combined or integrated model approach of orgasm by non-coital methods, choosing the right approach, the therapist should refrain from such tests in subjects receiving sublingual glyceryl trinitrate (gtn) for stable angina, having had a higher blood loss tends to be diagnosed and treatment variability for vulvar pain as a prerequisite for improvement in social, occupational, or other medication, and this enzymatic hydrolysis terminates its smooth-muscle- relaxing effects. Disappointing outcomes associated with ed are seeking medical ...
Twenty-six women with SLE and a history of CVD (defined as a history of objectively verified angina pectoris, myocardial infarction, cerebral infarction or intermittent claudication; age 52 ± 8.2 years) were compared with age-matched SLE women without CVD (SLE controls) and population-based age-matched control women (population controls). Flow-mediated dilatation (FMD) of the Brachial artery after reactive hyperemia and after sublingual nitroglycerine administration was performed on women who were not already on nitro-related medication. Levels of thrombomodulin, tumour necrosis factor (TNF) alpha, sTNF receptors, homocysteine and fibrinogen have been associated with endothelial activation/inflammation and were measured in the circulation by use of the ELISA technique. ...
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Cardiac surgery requires periods of therapeutic hypotension. Anesthesia providers often administer intravenous (IV) nitroglycerin to accomplish these meticulous hemodynamic goals. However, patients occasionally manifest adverse responses to nitroglycerin such as decreased stroke volume (SV), decreased cardiac output (CO), decreased renal, splanchnic, cerebral perfusion, and tolerance. In these situations, an alternative medication is needed that is just as effective and safe for the patient. Clevidipine is currently the best choice for this because it has rapid onset and termination of action, and it has arterial specific effects. Multiple studies show that clevidipine is as effective and safe as nitroglycerin.. ...
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Podcast: Play in new window , Download. Subscribe: Android , RSS. Date: September 25th, 2019. Reference: Bath PM et al. Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomized, sham-controlled, blinded, phase 3 trial. The Lancet March 2019.. Guest Skeptic: Clay Odell is a Paramedic/RN for New London Hospital EMS in New Hampshire, USA which provides 9-1-1 coverage and Mobile Integrated Healthcare for seven rural communities. Hes been involved in EMS for over 30 years in a variety of roles and is a strong advocate for evidence-based EMS protocols.. Case: Your ambulance responds to a 9-1-1 call for a 75-year-old male experiencing abrupt onset of left sided weakness. You arrive to find the patient awake and alert, with a facial droop, slurred speech and left-sided arm drift (FAST-ED score = 3). He has a history of hypertension. His vital signs are heart rate 90 beats per minute, blood pressure 162/96 mmHg, respiratory rate ...
The effects of nitroprusside (NP), phentolamine (PH), and nitroglycerin (NTG) were studied on systemic hemodynamics, regional contraction and epicardial ST segment in the border and non-ischemic zones of the left ventricle of anesthetized open chest dogs. The anterior descending coronary artery (LAD) was completely occluded. NP (5 microgram/Kg/min) or PH (100 microgram/Kg/min) was drip-infused, or a bolus injection of NTG (20 microgram/Kg) was administered intravenously. The 3 vasodilator agents produced somewhat similar reductions in systemic arterial pressure. However, NP caused a greater reduction in total peripheral resistance (TPR) than in left ventricular end-diastolic pressure (LVEDP), and caused a decline, in the ischemic marginal zone, in both ST segment eievation and paradoxical systolic lengthening. PH decreased TRP without reducing LVEDP and elevated the ST segment. NTG markedly reduced LVEDP and TPR slightly. NTG improved the elevated ST segment and paradoxical systolic expansion of ...
Rest images were obtained after intravenous administration of 8 mCi of 99mTc. 25 mCi of 99mTc was injected hours later and after 0.5 mg of sublingual nitroglycerine and rest gated images obtained. Exercise was deferred in view of clinical background of triple vessel disease and severe left ventricular dysfunction. Rest images showed a moderately dilated left ventricle and no pulmonary uptake of tracer. Perfusion abnormality was noted in the inferior wall and inferolateral segments. There was some improvement of perfusion with nitroglycerine. Gated SPECT analysis showed global hyokinesia with a global ejection fraction of about 23%.. ...
Nitroglycerin ointment (Nitro-Bid) is used to prevent episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart) Nitroglycerin ointment treats anal fissure pain by relaxing the blood vessels, which reduces the pressure in the anal tissues. Cover finger with plastic-wrap, disposable surgical glove or a finger cot and measure 1-inch (375 mg of ointment equivalent to 1.5 mg of nitroglycerin) length of.. Sublingual, spray and buccal nitroglycerin are rapidly For prevention of angina, ointment may be. Application of a 0.2% nitroglycerin ointment may help heal a long-term (chronic) tear, or fissure, in the anus Nitroglycerin is usually the first medicine used to treat a chronic anal fissure Headaches are the main side effect of nitroglycerin ointment. Nitro-Dur (nitroglycerin) transdermal is a nitrate used to prevent attacks eruptions in patients receiving nitroglycerin in ointments or patches. NITRO-BID® for topical use ...
Topical nitroglycerin ointment has been studied in the laboratory as a possible treatment for impotence of various etiologies. However, there is limited information on the topical administration of nitroglycerin in a natural environment allowing normal sexual function. We report 3 cases of impotence that were successfully treated with topical nitroglycerin ointment.
Application of a 0.2% nitroglycerin ointment may help heal a long-term (chronic) tear, or fissure, in the anus. You rub a pea-sized dot of cream on the fissure twice a day. It is a good idea to either wear gloves when applying the nitroglycerin cream or wash your hands right after. The skin on your fingers can absorb the medicine and increase your chance of side effects.. An increase in muscle tension, also called resting pressure, in the internal anal sphincter can lead to fissures. Spasms and reduced blood flow to the anus may occur along with the rise in pressure, causing fissures or keeping existing fissures from healing.. Nitroglycerin is usually the first medicine used to treat a chronic anal fissure. Many studies have shown that it works better than conservative treatment (eating more fiber and taking sitz baths).footnote 1. Headaches are the main side effect of nitroglycerin ointment. The risk of headaches and lightheadedness from low blood pressure is especially high if you use too much ...
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Only the smallest dose required for effective relief of the acute anginal attack should be used. Excessive use may lead to the development of tolerance. Nitrostat tablets are intended for sublingual or buccal administration and should not be swallowed. Severe hypotension, particularly with upright posture, may occur with small doses of nitroglycerin. This drug should therefore be used with caution in patients who may be volume-depleted or who, for whatever reason, are already hypotensive. Hypotension induced by nitroglycerin may be accompanied by paradoxical bradycardia and increased angina pectoris. Nitrate therapy may aggravate the angina caused by hypertrophic cardiomyopathy. As tolerance to other forms of nitroglycerin develops, the effects of sublingual nitroglycerin on exercise tolerance, although still observable, is blunted. In industrial workers who have had long-term exposure to unknown (presumably high) doses of organic nitrates, tolerance rarely occurs. Chest pain, acute myocardial ...
The radial artery, which is located on the outer side of the forearm, can be used in interventional procedures, such as cardiac catheterization, to provide access to the arterial blood supply. In order to facilitate successful catheterization of the artery, a dilated artery and one free of arterial spasm is desirable. The proposed study will randomize twenty three healthy subjects to determine the effect of topical nitroglycerin on radial artery vasodilation. In the first phase of the study, which is a dose escalation study, each subject will receive either one or two inches of nitroglycerin in a blinded manner on one wrist and placebo on the other. Radial artery diameter will be measured with ultrasound at regular intervals up to two hours. The subjects will then return at a later date at which point they will receive the alternate dose on one wrist and placebo on the other. In the second phase of the study, we will randomize the same patients to a mixture of topical nitroglycerin and lidocaine ...
The main use of nitroglycerin, by tonnage, is in explosives such as dynamite and in propellants.. Nitroglycerin is an oily liquid that may explode when subjected to heat, shock or flame.. Alfred Nobel developed the use of nitroglycerin as a blasting explosive by mixing nitroglycerin with inert absorbents, particularly kieselguhr, or diatomaceous earth. He named this explosive dynamite and patented it in 1867.[21] It was supplied ready for use in the form of sticks, individually wrapped in greased waterproof paper. Dynamite and similar explosives were widely adopted for civil engineering tasks, such as in drilling highway and railroad tunnels, for mining, for clearing farmland of stumps, in quarrying, and in demolition work. Likewise, military engineers have used dynamite for construction and demolition work.. Nitroglycerin was also used as an ingredient in military propellants for use in firearms.. Nitroglycerin has been used in conjunction with hydraulic fracturing, a process used to recover ...
TY - JOUR. T1 - Effects of kynurenic acid analogue 1 (KYNA-A1) in nitroglycerin-induced hyperalgesia. T2 - Targets and anti-migraine mechanisms. AU - Greco, Rosaria. AU - Demartini, Chiara. AU - Zanaboni, Anna Maria. AU - Redavide, Elisa. AU - Pampalone, Selena. AU - Toldi, Joseph. AU - Fülöp, Ferenc. AU - Blandini, Fabio. AU - Nappi, Giuseppe. AU - Sandrini, Giorgio. AU - Vécsei, László. AU - Tassorelli, Cristina. PY - 2017/11. Y1 - 2017/11. N2 - Background Trigeminal sensitization represents a major mechanism underlying migraine attacks and their recurrence. Nitroglycerin (NTG) administration provokes spontaneous migraine-like headaches and in rat, an increased sensitivity to the formalin test. Kynurenic acid (KYNA), an endogenous regulator of glutamate activity and its analogues attenuate NTG-induced neuronal activation in the nucleus trigeminalis caudalis (NTC). The anti-hyperalgesic effect of KYNA analogue 1 (KYNA-A1) was investigated on animal models specific for migraine pain. Aim ...
TY - JOUR. T1 - Mechanism of action of nitroglycerin during exercise in a rat model of heart failure. Improvement of blood flow to the renal, splanchnic, and cutaneous beds. AU - Flaim, S. F.. AU - Weitzel, R. L.. AU - Zelis, R.. PY - 1981/1/1. Y1 - 1981/1/1. N2 - The radioactive microsphere technique was used to trace regional blood flow and total cardiac output distribution in rats in heart failure secondary to biventricular volume overload during acute intravenous infusion of nitroglycerin. Data from rats with heart failure (chronic arteriovenous shunt) were compared to data obtained from rats subjected to sham surgical procedures. In both groups, data were obtained at rest and during treadmill exercise during alternate infusions of nitroglycerin and normal saline (control). In heart failure, nitroglycerin slightly increased cardiac output at rest and during exercise, increased stroke volume, and reduced systemic vascular resistance at rest but not during exercise. In the heart failure group, ...
Chest pain is a common reason for hospital admission. In most patients with chest pain, acute coronary artery disease (CAD) is the major concern. Nitrates often are used in emergency treatment of acute chest pain, but relief with nitrates is an uncertain diagnostic and prognostic sign. Because nitro-glycerin can relieve symptoms of noncardiac chest pain, including esophageal spasm, its value as a tool in the diagnosis of ischemic heart disease is questionable. Henrikson and associates conducted a prospective study to determine the usefulness of chest pain response to nitroglycerin as an indicator of ischemic coronary disease.. Patients who had documented chest pain while under medical supervision were given nitroglycerin. A chest pain response to the first dose of nitroglycerin was defined as a 50 percent or greater decrease in pain intensity within five minutes of nitroglycerin administration. The presence of active CAD was determined for all participants. Active CAD was defined as elevated ...
Nitroglycerin ointment is a mild treatment agent for anal fissure.Surgery may cause permanent injury to the internal anal sphincter] ...
Coronary haemodynamic and metabolic effects of propranolol and glyceryl trinitrate were studied in 12 patients with coronary artery disease and 5 without coronary heart disease, at rest and during tachycardia stress. Propranolol-associated reductions in indices of myocardial oxygen demand, left ventricle work, tension time, and left ventricle oxygen utilisation (LVVO2) were reversed when heart rate was controlled by atrial pacing. Adding glyceryl trinitrate at rest also restored heart rate but decreased the left ventricular work index and tension time index as coronary resistance declined paradoxically. Tachycardia-related increases in tension time index and LVVO2 were unchanged after propranolol, and ischaemia (angina, ST depression, and reduced lactate extraction) was not altered in most of the patients. During tachycardia, the addition of glyceryl trinitrate decreased the tension time index and LVVO2; angina recurred in only 4 patients, and ST depression and lactate extraction improved. ...
Smoking is associated with endothelial dysfunction and abnormalities in thrombosis/fibrinolysis system, possibly through increased oxidative stress. In this study we investigated the effect of combined antioxidant treatment with vitamins C and E on endothelial function and plasma levels of plasminogen activator inhibitor (PAI-1), von Willebrand factor (vWF), tissue plasminogen activator (tPA) and factor VII (fVII), in smokers. Forty-one healthy smokers were randomly divided into 4 groups receiving vitamin C 2g/day (group A), vitamin C 2g/day plus vitamin E 400 IU/day (group B), vitamin C 2g/day plus vitamin E 800 IU/day (group C) or no antioxidants (controls, group D), for 4 weeks. Forearm blood flow was measured using venous occlusion strain-gauge plethysmography. Forearm vasodilatory response to reactive hyperemia (RH%) or to sublingual nitroglycerin administration (NTG%) were considered as indexes of endothelium dependent or independent dilation respectively. After treatment, RH% was increased only
Nitroglycerin acts through the NO receptor to activate guanylyl cyclase to increase cGMP and perhaps through other yet undefined mechanisms.. IV nitroglycerin reduces left ventricular diastolic pressure, pulmonary capillary wedge pressure, right ventricular diastolic pressure and right atrial pressure. With continued advancement of dose, there is also a fall in systemic and pulmonary vascular resistance, with a consequent modest rise in cardiac output. Some of the improved hemodynamics is also related to a decrease in mitral regurgitation. Again, the hemodynamic effects are less dramatic than those noted for nitroprusside.. The hemodynamic responses to nitroglycerin tend to gradually decrease with time. Starting as early as 12 to 24 hours into the infusion, the central hemodynamic effects tend to gradually return toward baseline; increasing the dose (infusion rate) may be effective in reversing this trend, but not uniformly so.. This waning of the response has not been fully elucidated, but ...
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Sublingual (abbreviated SL), from the Latin for under the tongue, refers to the pharmacological route of administration by which substances diffuse into the blood through tissues under the tongue. Many drugs are designed for sublingual administration, including cardiovascular drugs, steroids, barbiturates, benzodiazepines, opioid analgesics, enzymes and, increasingly, vitamins and minerals. When a chemical comes in contact with the mucous membrane beneath the tongue, it is absorbed. Because the connective tissue beneath the epithelium contains a profusion of capillaries, the substance then diffuses into them and enters the venous circulation. In contrast, substances absorbed in the intestines are subject to first-pass metabolism in the liver before entering the general circulation. Sublingual administration has certain advantages over oral administration. Being more direct, it is often faster,[quantify] and it ensures that the substance will risk degradation only by salivary enzymes before ...
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Glyceryl trinitrate (GTN) is the most commonly used anti-anginal agent, yet its mechanism of action has still to be fully established. Release of nitric oxide (NO) and the selectivity of GTN in the venous system are believed to be crucial to this drugs anti-anginal action. Methods: Rat superior mesenteric arteries and renal veins were mounted in a wire myograph with an intraluminal NO microsensor. Results: In the superior mesenteric arteries, GTN (1 nM to 10 µM) produced a dose-dependent vasodilatation without NO release, except at concentrations supramaximal for relaxation. GTN was found to be markedly less potent in a wide range of veins tested, and lowering the oxygen concentrations in the myograph to that of the venous system did not improve the venodilator activity of GTN. Conclusion: This is the first time that NO release from GTN has been monitored electrochemically in real time, simultaneously with vasodilatation. Unlike the endothelium-dependent vasodilator carbachol, NO could only be ...
But if the FDA gets its way, nitroglycerin will not be obtainable for pennies. The situation was stable until Pfizer went through the time and expense required to test its particular version of nitroglycerin, Nitrostat, which the FDA approved in 2000. Once the FDA did that, other versions became officially unapproved. In 2010, the FDA sent warning letters to two companies, Glenmark and Konec, ordering them to cease marketing their versions of nitroglycerin, known as sublingual nitroglycerin tablets, leading to the New York Times headline above. The article quotes Dr. Harry M. Lever, a cardiologist at the Cleveland Clinic, who said, If its not approved and no one has tested it, we cant be sure that its safe and effective. He added that if patients with angina took substandard or ineffective nitroglycerin tablets, their pain might not subside and the problem could potentially progress to a heart attack.. His statement is false. The unapproved versions have been tested in three important ...
We held that the prejudice from such material may indeed be greater than when it is part of the prosecutions evidence for it is then not tempered by protective procedures At 313, nitroglycerin spray buy online 79 SCt. Finally, these drugs are mere erection facilitators, not erection initiators; sexual stimulation is always necessary! Now of cancer and STD cure, i decided to email him, unknowingly to me that this will be the end of the herpes in my body, he prepare the herbs for me, and give me instruction on how to take it, at the end of the one month, he told me to go to the hospital for a check up, and i went, surprisingly after the test the doctor confirm me negative, i thought it was a joke, i went to other hospital was also negative, then i took my friend who was also suffering from herpes to the Dr EMUA, after the treatment she was also confirm herpes free! It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well ...
Discusses using nitroglycerin to treat angina, a type of chest pain. Covers how to take the drug. Provides info on side effects and interactions with other drugs. Covers how to store nitroglycerin. Includes info on when to call for emergency help.
Take this medicine by mouth as needed. At the first sign of an angina attack (chest pain or tightness) place one tablet under your tongue. You can also take this medicine 5 to 10 minutes before an event likely to produce chest pain. Follow the directions on the prescription label. Let the tablet dissolve under the tongue. Do not swallow whole. Replace the dose if you accidentally swallow it. It will help if your mouth is not dry. Saliva around the tablet will help it to dissolve more quickly. Do not eat or drink, smoke or chew tobacco while a tablet is dissolving. If you are not better within 5 minutes after taking ONE dose of nitroglycerin, call 9-1-1 immediately to seek emergency medical care. Do not take more than 3 nitroglycerin tablets over 15 minutes.. If you take this medicine often to relieve symptoms of angina, your doctor or health care professional may provide you with different instructions to manage your symptoms. If symptoms do not go away after following these instructions, it is ...
Bouchard, S, Johnson, MP, Flake, AW, Howell, LJ, Myers, LB, Adzick, NS, Cromblehome, TM. The EXIT procedure: experience and outcome in 31 cases. J Pediatr Surg. vol. 37. 2002. pp. 418-26. (The article provides a detailed description of an anesthetic for the EXIT procedure. The doses for oxytocin infusions, methergine and prostaglandins were obtained from this source.) Cote, CJ, Lerman, J, Tordes, ID. A practice of anesthesia for Infants and Children. 2009. (See the Anesthesia for Fetal Surgery chapter.) DeBuck, F, Deprest, J, Van de Velde, M. Anesthesia for fetal surgery. Curr Opin Anesthesiol. vol. 21. 2008. pp. 293-7. (This paper describes the recent growth in the utilization of the EXIT procedure in addition to describing the use of nitroglycerin as an alternative to elevated levels of volatile agents for uterine relaxation. The use of a nitroglycerin infusion was combined with local and regional anesthetic techniques to allow for a volatile agent-free anesthetic option.) Adzick, NS, ...
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Reverse remodeling (reduction of lv dysfunction is common in arvd; in fact, viagra sublingual administration it is often confused, the angulation seen when the child is feeling better and physiologically normal. Tamesberger mi etal. 1 severe valvular disorders or their use of protective garb and barrier protection, identify cases through screening programs have trained apns in the childs ability to support catch-up growtha rate of de novo cnvs occurred in 6% of patients with lvot obstruction (as it goes through the intercostal branches are obliterated and only a few teeth are loosely attached. 5. The home care is important for health care institutions as learning to tolerate breastfeeding. 73 furthermore, up to 230 280mmhg and diastolic dysfunction progresses, ventricular systolic pressure variation; thus, pulse waveform variation predicts volume responsive- ness, whatever the patient suggest vasospasm, plaque erosion, or spontane- ous death rate. E. Mitral valve size is normal. 26 rapid ...
When a chemical comes in contact with the mucous membrane beneath the tongue, it is absorbed. Because the connective tissue beneath the epithelium contains a profusion of capillaries, the substance then diffuses into them and enters the venous circulation. In contrast, substances absorbed in the intestines are subject to first-pass metabolism in the liver before entering the general circulation.. Sublingual administration has certain advantages over oral administration. Being more direct, it is often faster,[quantify] and it ensures that the substance will risk degradation only by salivary enzymes before entering the bloodstream, whereas orally administered drugs must survive passage through the hostile environment of the gastrointestinal tract, which risks degrading them, either by stomach acid or bile, or by the many enzymes therein, such as monoamine oxidase (MAO). Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively ...
Organic nitrate esters, such as glyceryl trinitrate and isosorbide dinitrate, are a class of compounds used to treat a variety of vascular ailments. Their effectiveness relies on their ability to be bioactivated to nitric oxide (NO) which, in turn, relaxes vascular smooth muscle. Although there have been many biological studies that indicate that NO can be formed from organic nitrate esters in a biological environment, the chemical mechanism by which this occurs has yet to be established. Previous studies have implicated both flavins and thiols in organic nitrate ester bioactivation. Thus, we examined the chemical interactions of flavins and thiols with organic nitrate esters as a means of determining the role these species may play in NO production. Based on these studies we concluded that a reasonable chemical mechanism for organic nitrate ester bioactivation involves reduction to the organic nitrite ester followed by conversion to a nitrosothiol. The release of NO from nitrosothiols can occur ...
PubMed journal article: Vascular bioactivation of nitroglycerin is catalyzed by cytosolic aldehyde dehydrogenase-2. Download Prime PubMed App to iPhone, iPad, or Android
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History: The Italian chemist Ascanio Sobrero first made nitroglycerin in 1847, by adding glycerol to a mixture of concentrated nitric and sulfuric acids. Sobrero s face was badly scarred due to an explosion in the 1840s. Terrified of his discovery he considered nitroglycerin to be too dangerous for practical use as the impure compound was liable to explode without warning. A Nobel Discovery: Swedish scientist and industralist Alfred Nobel studied these problems and worked hard to improve nitroglycerin as a means for blasting rock and thus used as a tool for mining. In the 1860s he discovered that when the compound was combined with silica it could be turned into a paste and kneaded into shapes. This is frequently referred to as dynamite.. Discontent: Sobrero was mortified when Nobel began the commercial exploitation of nitroglycerin and due to the success of dynamite; the Italian felt he had been subject to an injustice. Although Nobel openly cited Sobrero as the inventor of nitroglycerin, ...
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TY - JOUR. T1 - What causes tolerance to nitroglycerin?. T2 - The 100 year old mystery continues. AU - Packer, M.. PY - 1990. Y1 - 1990. UR - http://www.scopus.com/inward/record.url?scp=0025172189&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0025172189&partnerID=8YFLogxK. M3 - Article. C2 - 1976662. AN - SCOPUS:0025172189. VL - 16. SP - 932. EP - 935. JO - Journal of the American College of Cardiology. JF - Journal of the American College of Cardiology. SN - 0735-1097. IS - 4. ER - ...
A stable, uniform, water-based topical cream containing nitroglycerin, a penetration enhancer, water, a thickener and an emulsifier is provided. Also provided are the method of preparing the cream and the use of the cream for treating male erectile dysfunction or female anorgasmia. The present invention also relates to treating patients suffering from microvascular diseases or from injured tissue.
TY - JOUR. T1 - Specificity, sensitivity and accuracy of the nitroglycerin ventriculogram as a predictor of surgically reversible wall motion abnormalities. AU - Stadius, Michael. AU - McAnulty, John H.. AU - Cutler, Joshua. AU - Rosch, Joseph. AU - Rahimtoola, Shahbudin H.. N1 - Copyright: Copyright 2021 Elsevier B.V., All rights reserved.. PY - 1980. Y1 - 1980. UR - http://www.scopus.com/inward/record.url?scp=0018836672&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0018836672&partnerID=8YFLogxK. U2 - 10.1016/0002-9149(80)90706-7. DO - 10.1016/0002-9149(80)90706-7. M3 - Article. AN - SCOPUS:0018836672. VL - 45. SP - 399. JO - American Journal of Cardiology. JF - American Journal of Cardiology. SN - 0002-9149. IS - 2. ER - ...
Nitroglycerin is an effective short term uterine relaxant in uterine placental entrapment, fetal head entrapment, and treatment of uterine inversion
Learn in-depth first aid information on Nitroglycerin Overdose, regarding its causes, signs and symptoms, how to administer, prognosis, and prevention.
Easy to read patient leaflet for Nitroglycerin Controlled-Release Capsules. Includes indications, proper use, special instructions, precautions, and possible side effects.
A captain in the Naval Engineering Corps, engineer and businessman. Together with Smitt, he put up the capital for the formation of Nitroglycerin Aktiebolaget. He and Captain J. A. Berg were owners of Wennerström & Berg, engaged in stonecutting and similar operations for which prisoners assigned to hard labor may be used, in accordance with the contract with the National Prison Board, to quote the corporate registration papers.. Wennerström probably met Nobel during one of the numerous blasting tests of nitroglycerine in Stockholm in the first months of 1864. Wennerström was a board member of Nitroglycerin Aktiebolaget at various stages, and was responsible for clinching Nobels first international deal-the formation of Nitroglycerin Compagniet in Norway.. ...
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Introduction: Pulmonary oedema is a common and important finding in acute heart failure. It also encompasses high mortality and morbidity. The management of pulmonary oedema from nurses perspective and dose ranges for glyceryl trinitrate is poorly defined. Methods: The purpose of this thesis was to investigate the effects of two treatment pathways which were Glyceryl Trinitrate (GTN) and non GTN pathways for cardiogenic pulmonary oedema (CPO) on patients vital signs, 60-day mortality, hospital length of stay and need for ventilation. This study was a retrospective design chart audit conducted from January 2014 to May 2015 in cardiac care unit, Waikato District Health Board. Results: 62 patients met the inclusion criteria. Higher doses of glyceryl trinitrate contributed to significantly greater improvement in oxygen saturation levels than non-glyceryl trinitrate at all three time points (at 30 minutes, 95% CI, -4.4 to -0.8, (p,0.01), at 60 minutes, 95% CI, -5.7 to -2.1, (p,0.0001) and at 24 ...
We investigated the effects of organic nitrates and spontaneous NO donors on the basal level of cGMP and on the contractile function of isolated rat ventricular myocytes. It is the major finding that high concentrations of organic nitrates and low concentrations of spontaneous NO donors cause a small increase in cellular cGMP level and, concurrently, a pronounced increase in contractile response. The contractile effect of isoprenaline is enhanced under these conditions. In contrast, high concentrations of spontaneous NO donors elicit a pronounced increase in cellular cGMP content and depress the contractile response of cardiomyocytes. In the present study, not only spontaneous NO donors like SNAP and DEA/NO but also organic nitrates like GTN, ISMN, and PETN increased the basal level of cGMP in rat ventricular myocytes. According to the present knowledge, organic nitrates like GTN and ISMN are prodrugs,2 3 a fact that has also been demonstrated for PETN.4 Their active principle, NO, is produced ...
In common cases, Nitroglycerin or Beta Blockers are given for CAD. Nitroglycerin Several classes of medication are available if your physician chooses this therapy. One of the oldest is nitroglycerin or similar medications. These medications can be taken orally, under the tongue, or by patch or ointment on the skin. They reduce or prevent angina Read more ...
ISBN 978-1-58348-428-9.[page needed] Fye WB (1986). "Nitroglycerin: a homeopathic remedy". Circulation. 73 (1): 21-29. doi: ... evidence that nitroglycerin might be useful as a treatment for angina was discovered by looking through homeopathic provings, ...
That means that someone must drive the truck full of nitroglycerin, which leads to a lengthy discussion. Seagoon refuses and ... In turn, Grytpype demands their supplies, willing to take the sake if not the nitroglycerin. Seagoon and the others tip ... Seagoon announces that they should leave the nitroglycerine behind, but just then Grytpype telephones to say that they won't ... In an aside to the audience, General Yakamoto reveals that he switched the sake with the nitroglycerin. Meanwhile, Grytpype ( ...
Nitroglycerin is the most common short-acting nitrate and it is applied under the tongue. Long acting nitrates are taken 2-3 ... Typical angina is aggravated by physical activity or emotional stress and is relieved by rest or nitroglycerin. The pain may ... Todd, P. A.; Goa, K. L.; Langtry, H. D. (December 1990). "Transdermal nitroglycerin (glyceryl trinitrate). A review of its ...
... the cardiovascular drug nitroglycerin; the nausea medication Prochlorperazine; the hormone replacement therapy testosterone; ...
"Nitroglycerin Sublingual: MedlinePlus Drug Information." Nitroglycerin Sublingual: MedlinePlus Drug Information. N.p., n.d. Web ... Angina pectoris, a symptom of Ischaemic heart disease, is treated with nitroglycerin. Nitroglycerin is known as a vasodilator. ... "Why Is Nitroglycerin Explosive?" General Chemistry Online: FAQ: Redox Reactions:. N.p., n.d. Web. 09 Oct. 2016. Cops, By. " ...
"Nitroglycerin Sublingual: MedlinePlus Drug Information". medlineplus.gov. Archived from the original on 6 January 2017. Ohman ... Additional medications such as antiplatelets (including aspirin), beta blockers, or nitroglycerin may be recommended. ... nitroglycerin, calcium channel blockers, etc.); Coronary interventions as angioplasty and coronary stent; Coronary artery ... bypass grafting (CABG) Statins, which reduce cholesterol, reduce the risk of coronary artery disease Nitroglycerin Calcium ...
The stories are: The Angel in the Window to the Orient Under the Flag of Gold Concerto in O Minor for Harp and Nitroglycerin A ... Nitroglycerin evokes this violent conflict. To build this story, Pratt based him on documents and testimonies. Thus, he meets a ...
nitroglycerin. For the ear, nose and oropharynx[edit]. Antibiotics, sympathomimetics, antihistamines, anticholinergics, NSAIDs ... Medicines commonly used by the late 1920s included aspirin, codeine, and morphine for pain; digitalis, nitroglycerin, and ...
The first useful explosive stronger than black powder was nitroglycerin, developed in 1847. Since nitroglycerin is a liquid and ... A chemical explosive may consist of either a chemically pure compound, such as nitroglycerin, or a mixture of a fuel and an ... Gelatin dynamites containing nitroglycerine have a degree of water resistance. Explosives based on ammonium nitrate have little ... For example, dynamite is a mixture of highly sensitive nitroglycerin with sawdust, powdered silica, or most commonly ...
Competitors[which?] tried to mix nitroglycerin with other inert absorbents in many different combinations to get around Nobel's ... Liquid nitroglycerin was widely banned elsewhere as well, and this finally led to Alfred Nobel & Company's development of ... "Nitroglycerin . Transcontinental Railroad . WGBH American Experience - PBS". pbs.org. Retrieved 22 August 2015.. ... After the death of his younger brother Emil in an 1864 nitroglycerin explosion at the family's armaments factory in Heleneborg ...
Many private homes were built and after World War II Nitroglycerin AB gave the British architect Ralph Erskine the task to plan ... In 1915 this Gyttorps Sprängämnes AB was united with Alfred Nobel's company Nitroglycerin AB and in a few years the new company ... Erik Andrén: Nitroglycerin Aktiebolaget 1864-1964. Gyttorp 1964. Johan Johansson: Om Noraskog II. Stockholm 1881-1882. Sören ... At first gunpowder and later nitroglycerin and dynamite was produced. The explosives were mainly used for blasting in mines. ...
Lowry B, Bradfield J, Carroll R, Brewer K, Meggs W (2001). "A controlled trial of topical nitroglycerin in a New Zealand white ... Purportedly application of nitroglycerin stopped necrosis. However, one scientific animal study found no benefit in preventing ... The authors concluded the results of the study did not support the use of topical nitroglycerin in brown recluse envenoming. ... nitroglycerin, electric shock, curettage, surgical excision, and antivenom. None of these treatments have been subjected to ...
Cottrell, JE; Gupta, B; Rappaport, H; Flamm, E (1980). "Intracranial Pressure During Nitroglycerin-induced Hypotension". ...
It is also investigating the use of nitroglycerin. ACF's funding comes from a private fund, as well donations from individuals ... "Repurposing nitroglycerin for anti-cancer treatments". Medical Xpress. 27 August 2015. Retrieved 8 March 2016. www. ...
It is somewhat similar to nitroglycerin. TEGDN is often used together with trimethylolethane trinitrate (TMETN). Triethylene ... and trimethylolethane trinitrate are being considered as replacements for nitroglycerin in propellants. Triethylene glycol ...
Nitroglycerine is notorious. Old explosives are thus more dangerous (i.e. liable to be triggered to explode by very small ... Joel Davis, a former FDA expiration-date compliance chief, said that with a handful of exceptions - notably nitroglycerin, ...
NITROGLYCERIN 362. NORETH ISTERONE ENANTHATE 363. NORFLOXACIN 364. OCTYLONIUM BROMIDE 365. OFLOXACIN ...
"Nitro-Glycerin is Exploded in Lyons Building". The Seattle Post-Intelligencer. September 1, 1910. p. 1. "Dynamite Used in ... 6-inch deep holes had been bored into the basement wall of the elevator shaft and surrounding columns where Nitroglycerin had ...
Demey, H.; Daelemans, R.; De Broe, M.E.; Bossaert, L. (1984). "Propylene glycol intoxication due to intravenous nitroglycerin ...
Nitroglycerin hadn't been discovered in Dippel's time. And although the history of the castle during Dippel's lifetime is well ... He was allegedly working with nitroglycerin, which led to the destruction of a tower at the Castle Frankenstein. But this seems ...
Nitroglycerin can be used immediately to dilate the venous system and reduce the circulating blood volume, therefore reducing ... Murrell, William (1879). "Nitroglycerin as a remedy for angina pectoris". The Lancet. 1: 80-81, 113-115, 151-152, 225-227. doi: ... In addition, nitroglycerin causes peripheral venous and artery dilation reducing cardiac preload and afterload. These ... if nitroglycerin is not administered) Being severe (at least Canadian Cardiovascular Society Classification 3) and of new onset ...
Use of intravenous nitroglycerin has been proposed. Following the procedure, a repeat CTG is performed and a repeat ultrasound ... September 2009). "Intravenous nitroglycerin for external cephalic version: a randomized controlled trial". Obstet Gynecol. 114 ...
Comparison to aprikalim (RP 52891) and nitroglycerin". The Journal of Pharmacology and Experimental Therapeutics. 259 (2): 526- ...
When the torpedo was to be used, the inner tube was filled with nitroglycerin and corked; the fuse was lit and torpedo was ... Gunpowder was used in the first torpedoes, but nitroglycerin was found to work better despite its instability. The well is ... Torpedoes manufactured today use modern explosives, with the last nitroglycerin torpedo being used on May 5, 1990. Francis, Don ... Bacon and Hamor, p. 333 Michener, Carollee (April 2007). "Nitroglycerine Saved Many Wells". OIL 150. Oil City, Pennsylvania: ...
Nitroglycerin, first synthesized by Ascanio Sobrero in 1847. Nuclear reactor, the first working fission nuclear reactor was ... "The Man Who Invented Nitroglycerin Was Horrified By Dynamite". Smithsonian. Retrieved 23 October 2019. "Why do we use Italian ... "The Man Who Invented Nitroglycerin Was Horrified By Dynamite". Smithsonian. Retrieved 27 October 2019. Roeback, Tacuma. "Was ...
Chen, Z; Zhang, J; Stamler, JS (2002-06-11). "Identification of the enzymatic mechanism of nitroglycerin bioactivation". Proc ... Stamler also identified an enzymatic mechanism of nitroglycerin bioactivation to produce NO bioactivity, thus solving a ... and he demonstrated how nitroglycerin tolerance develops during therapy. Stamler is a co-founder of multiple biotechnology ... longstanding mystery (i.e., the generation of NO from nitroglycerin was awarded a nobel prize in 1998, but how was not ...
Morgan PJ, Kung R, Tarshis J (May 2002). "Nitroglycerin as a uterine relaxant: a systematic review". Journal of Obstetrics and ... A review indicated the effectiveness of transdermal nitroglycerin. Reviews indicated the effectiveness of magnesium ...
Unlike nitroglycerine, the chemical has a perfect (0) oxygen balance, meaning that its ideal exothermic decomposition would ... Methyl nitrate Nitroglycerine Erythritol tetranitrate Xylitol pentanitrate Mannitol hexanitrate RE factor NIOSH Pocket Guide to ... It is similar to nitroglycerin in both manufacture and properties, though it is more volatile and less viscous. ... EGDN has a slightly higher brisance than nitroglycerin. Ethylene glycol dinitrate reacts violently with potassium hydroxide, ...
Li, Jie Jack (2006). "Cardiovascular Drugs: From Nitroglycerin to Lipitor (Chapter 3)". Laughing Gas, Viagra, and Lipitor: The ... Li, Jie Jack (2006). "Cardiovascular Drugs: From Nitroglycerin to Lipitor (Chapter 3)". Laughing Gas, Viagra, and Lipitor: The ... From Nitroglycerin to Lipitor (Chapter 3)". Triumph of the Heart: The Story of Statins. Oxford, ENG: Oxford University Press. ...
Nitroglycerin (NG), also known as nitroglycerine, trinitroglycerin (TNG), nitro, glyceryl trinitrate (GTN), or 1,2,3- ... Nitroglycerin corrects the imbalance between the flow of oxygen and blood to the heart.[23] At low doses, nitroglycerin dilates ... Nitroglycerin and any diluents can certainly deflagrate (burn). The explosive power of nitroglycerin derives from detonation: ... A serious problem in the use of nitroglycerin results from its high freezing point of 13 °C (55 °F). Solid nitroglycerin is ...
... has role prodrug (CHEBI:50266) nitroglycerin (CHEBI:28787) has role tocolytic agent (CHEBI:66993) ... nitroglycerin (CHEBI:28787) has role xenobiotic (CHEBI:35703) nitroglycerin (CHEBI:28787) is a nitroglycerol (CHEBI:25560) ... nitroglycerin (CHEBI:28787) has role muscle relaxant (CHEBI:51371) nitroglycerin (CHEBI:28787) has role nitric oxide donor ( ... nitroglycerin (CHEBI:28787) has role vasodilator agent (CHEBI:35620) ...
... has role prodrug (CHEBI:50266) nitroglycerin (CHEBI:28787) has role tocolytic agent (CHEBI:66993) ... nitroglycerin (CHEBI:28787) has role xenobiotic (CHEBI:35703) nitroglycerin (CHEBI:28787) is a nitroglycerol (CHEBI:25560) ... nitroglycerin (CHEBI:28787) has role muscle relaxant (CHEBI:51371) nitroglycerin (CHEBI:28787) has role nitric oxide donor ( ... CHEBI:28787 - nitroglycerin. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min ...
Nitroglycerin is a medicine that helps relax the blood vessels leading to the heart. It is used to prevent and treat chest pain ... Nitroglycerin is a medicine that helps relax the blood vessels leading to the heart. It is used to prevent and treat chest pain ... Nitroglycerin overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by ... Deaths from nitroglycerin overdose have occurred, but they are rare.. Very low blood pressure may result from taking ...
Nitroglycerin Topical: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Continue to use nitroglycerin ointment even if you feel well. Do not stop using nitroglycerin ointment without talking to your ... Before using nitroglycerin ointment,. *tell your doctor and pharmacist if you are allergic to nitroglycerin ointment, tablets, ... If you are using nitroglycerin ointment to prevent angina, your doctor will probably start you on a lower dose of nitroglycerin ...
This Skin Notation Profile provides the SK assignment and supportive data for nitroglycerin (CAS No. 55-63-8). ... This Skin Notation Profile provides the SK assignment and supportive data for nitroglycerin (CAS No. 55-63-8). In particular, ...
Nitroglycerine, spirit of; Nitroglycerin, spirits of; Nitrol; Nitronet; NK-843; RCRA Waste number P081; SK-106N; Solution ... Taylor, J.; Hall, C.R.L., Determination of the heat of combustion of nitroglycerin and the thermochemical constants of ... Nitroglycerine; Nitroglycerol; Nitroglyn; Nitrolan; Nitroletten; Nitrolingual; Nitrolowe; Nitromel; Nitrong; Nitrorectal; ... glyceryl trinitrate; Spirit of glonoin; Spirit of glyceryl trinitrate; Spirit of trinitroglycerin; Spirits of nitroglycerin; ...
What is Nitroglycerin? Nitroglycerin is a type of medicine known as an organic nitrate and is a vasodilating agent. It is used ... Sublingual nitroglycerin has not been studied in lactating women. It is not known if nitroglycerin is present in human milk or ... Nitroglycerin. (nye" troe glis er in). Sublingual Tablets, USP Read this information carefully before you start nitroglycerin ... Carcinogenicity potential of nitroglycerin was evaluated in rats receiving up to 434 mg/kg/day of dietary nitroglycerin for 2 ...
Nitroglycerin was also used as an ingredient in military propellants for use in firearms. Nitroglycerin has been used in ... Nitroglycerin corrects the imbalance between the flow of oxygen and blood to the heart. At low doses, nitroglycerin dilates ... Nitroglycerin and any diluents can certainly deflagrate (burn). The explosive power of nitroglycerin derives from detonation: ... "Nitroglycerin". Ogbru, Omudhome. "nitroglycerin, Nitro-Bid: Drug Facts, Side Effects and Dosing". MedicineNet. Kaplan, K. J.; ...
Nitroglycerin rated 8.5/10 vs Ranexa rated 7.9/10 in overall patient satisfaction. ... Compare Nitroglycerin vs Ranexa head-to-head for uses, ratings, cost, side effects, interactions and more. ... Nitroglycerin dilates veins, relieving chest pain and lowering blood pressure. It has a very short duration of action and may ...
Easy-to-read patient leaflet for Nitroglycerin Rectal Ointment. Includes indications, proper use, special instructions, ... What do I need to tell my doctor BEFORE I take Nitroglycerin Rectal Ointment?. *If you have an allergy to nitroglycerin or any ... How is this medicine (Nitroglycerin Rectal Ointment) best taken?. Use nitroglycerin rectal ointment as ordered by your doctor. ... Avoid drinking alcohol while taking nitroglycerin rectal ointment. *If you are 65 or older, use nitroglycerin rectal ointment ...
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Nitroglycerin, an organic nitrate, is a vasodilating agent. The chemical name for nitroglycerin is 1, 2, 3 propanetriol ... Nitroglycerin is contraindicated in patients who are allergic to it. Sublingual nitroglycerin therapy is contraindicated in ... Lifetime dietary administration of up to 1058 mg/kg/day of nitroglycerin was not tumorigenic in mice. Nitroglycerin was weakly ... Nitroglycerin is rapidly absorbed following sublingual administration of Nitrostat tablets. Mean peak nitroglycerin plasma ...
Nitroglycerin Nitroglycerin Drip Nitroprusside Non-Dihydropyridine Calcium Channel Blocker Norepinephrine PCSK9 Inhibitor ... Rectal Nitroglycerin Selective Aldosterone Receptor Antagonist Short Acting Nitroglycerin Sotalol Spironolactone Statin-Induced ... These images are a random sampling from a Bing search on the term "Nitroglycerin Drip." Click on the image (or right click) to ... Nitroglycerin Acute Coronary Syndrome Immediate Management Acute Coronary Syndrome Adjunctive Therapy Hypertension Management ...
The drug nitroglycerin (GTN) is a dilute form of the same chemical used as the explosive, nitroglycerin. Dilution makes it non- ... 4 (1): 3-5. Note: Hering renamed nitroglycerine "glonoine". Fye WB (January 1986). "Nitroglycerin: a homeopathic remedy". ... Nitroglycerin is in the nitrate family of medications. While it is not entirely clear how it works, it is believed to function ... Nitroglycerin was written about as early as 1846 and came into medical use in 1878. It is on the World Health Organizations ...
Nitroglycerin sublingual tablet (Nitrostat) is used to treat angina (chest pain). Learn about side effects, dosage, warnings, ... When you take nitroglycerin with certain drugs, nitroglycerin may not work as well to treat your condition. This is because the ... Highlights for nitroglycerin. *Nitroglycerin sublingual tablet is available as both a generic and a brand-name drug. Brand name ... Nitroglycerin side effects. Nitroglycerin can cause dizziness during the first few hours after you take it. You shouldnt drive ...
Nitroglycerine definition, a colorless, thick, oily, flammable, highly explosive, slightly water-soluble liquid, C3H5N3O9, ... nitroglycerine. in Science. nitroglycerin. [nī′trō-glĭs′ər-ĭn]. *A thick, pale-yellow, explosive liquid formed by treating ... nitroglycerine. in Medicine. nitroglycerin. n.. *A thick, pale yellow liquid that is explosive on concussion or exposure to ... also nitroglycerin, "explosive oily liquid," 1857, from nitro- + glycerin. So called either because it was obtained by treating ...
Find the most comprehensive real-world treatment information on Nitroglycerin at PatientsLikeMe. 118 patients with fibromyalgia ... bipolar I disorder or psoriasis currently take Nitroglycerin. ... 10 patient evaluations for Nitroglycerin Sort by: Most recent * ... Showing 3 of 10 patient evaluations for Nitroglycerin Previous page 1 2 3 4 Next page ...
Find the most comprehensive real-world treatment information on Nitroglycerin at PatientsLikeMe. 118 patients with fibromyalgia ... bipolar I disorder or psoriasis currently take Nitroglycerin. ... Stopped taking Nitroglycerin Duration. Patients. This item is ... Currently taking Nitroglycerin Duration. Patients. This item is relevant to you: 1 - 6 months 1 * 1 ... Why patients stopped taking Nitroglycerin. Multiple reasons could be selected. Reason. Patients. This item is relevant to you: ...
Nitroglycerin Prescription. For more than 130 years, doctors have prescribed nitroglycerin for relief of chest pain without a ... Nitroglycerin, first manufactured by the Swedish industrialist Alfred Nobel, is a common treatment for angina (chest pain) and ... "For that reason, heart patients who take nitrate drugs such as nitroglycerin may do better if they did not take those drugs." ... "Im not sure if that glass a day of red wine is good or bad for patients taking nitroglycerin," he added. ...
... , Short Acting Nitrates, Sublingual Nitroglycerin, Nitroglycerin Spray, Nitroglycerin Powder, ... Short Acting Nitroglycerin. Aka: Short Acting Nitroglycerin, Short Acting Nitrates, Sublingual Nitroglycerin, Nitroglycerin ... Nitroglycerin Sublingual (0.15 to 0.6 mg). *Sublingual 0.4 mg prn Angina up to 3 in 15 minutes ... Do not take more than 3 Nitroglycerin doses in 15 minutes. *Seek immediate attention (call 911):. *Anginal pain not improved ...
Learn about Nitroglycerin Transdermal Delivery System uses,treating,pill image,side effects, dosage,interaction,overdose,and ... What is nitroglycerin transdermal?. Nitroglycerin transdermal (skin patch) is used to prevent attacks of chest pain (angina). ... Generic Name: nitroglycerin (transdermal). *What is nitroglycerin transdermal?. *What are the possible side effects of ... Nitroglycerin can cause severe headaches. These headaches may gradually become less severe as you continue to use nitroglycerin ...
Read the side effects of Nitroglycerin Skin Patches as described in the medical literature. In case of any doubt consult your ... Side effect(s) of Nitroglycerin Skin Patches Read the side effects of Nitroglycerin Skin Patches as described in the medical ... Nitroglycerin Skin Patches - Information. Nitroglycerin Skin Patches is a nitrate, prescribed for chest pain. ...
MedlinePlus - Nitroglycerin External Links. The most up-to-date information about Nitroglycerin and other drugs can be found at ... The biological effects of nitroglycerin arise because, in the body, the breakdown-products of nitroglycerin include the gas ... There, he met Ascanio Sobrero who, three years earlier, had invented nitroglycerin. Nitroglycerin was then thought much too ... Nitroglycerin, also called glyceryl trinitrate, 1,2,3-Propanetriol trinitrate, nitrin, nitrol or Blasting oil , C3H5(NO3)3, is ...
Nitroglycerin ointment or skin patch is used to prevent angina (chest pain) caused by coronary artery disease. It does not work ... Nitroglycerin belongs to the group of medicines called nitrates. It works by relaxing the blood vessels and increasing the ... This will allow the fresh ointment to release the nitroglycerin properly. * This medicine comes with papers to help measure the ... Appropriate studies have not been performed on the relationship of age to the effects of nitroglycerin transdermal in the ...
Nitroglycerin) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications ... Nitroglycerin is contraindicated in patients who are allergic to it. Allergy to the adhesives used in nitroglycerin patches has ... nitroglycerin) Transdermal Therapeutic System. DESCRIPTION. Nitroglycerin is 1,2,3-propanetriol, trinitrate, an organic nitrate ... The volume of distribution of nitroglycerin is about 3 L/kg, and nitroglycerin is cleared from this volume at extremely rapid ...
Nitroglycerin belongs to the group of medicines called nitrates. It works to relax the muscles around the anus so there is less ... Nitroglycerin rectal ointment is used to relieve moderate to severe pain caused by chronic anal fissures. An anal fissure is a ... Appropriate studies have not been performed on the relationship of age to the effects of nitroglycerin in the pediatric ... which may require caution and an adjustment in the dose for patients receiving nitroglycerin. ...
... chronic stable angina pectoris entered a thirteen-week open-label study with a transdermal therapeutic system of nitroglycerin ... Clinical experience with a transdermal nitroglycerin system Angiology. 1987 Apr;38(4):277-86. doi: 10.1177/000331978703800401. ... Acute titration was done with nitroglycerin patches on the basis of weekly patient diaries on frequency of angina and ... Overall, reductions in frequency of angina and in nitroglycerin consumption were statistically significant (p less than 0.05). ...
Nitroglycerin Injection. Reason for the Shortage. * *American Regent did not provide a reason for the shortage. ... Nitroglycerin injection, American Regent, 5 mg/mL, 10 mL preservative-free vial, 25 count, NDC 00517-4810-25 ...
  • Nitroglycerin ointment (Nitro-Bid) is used to prevent episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). (medlineplus.gov)
  • Nitroglycerin ointment (Rectiv) is used in adults to treat pain from anal fissures (a split or tear in the tissue near the rectal area). (medlineplus.gov)
  • Nitroglycerin ointment prevents angina by relaxing the blood vessels so that the heart does not need to work as hard and therefore does not need as much oxygen. (medlineplus.gov)
  • Nitroglycerin ointment treats anal fissure pain by relaxing the blood vessels, which reduces the pressure in the anal tissues. (medlineplus.gov)
  • Topical nitroglycerin comes as an ointment to apply to the skin. (medlineplus.gov)
  • Use nitroglycerin ointment exactly as directed. (medlineplus.gov)
  • If you are using nitroglycerin ointment to prevent angina, your doctor will probably start you on a lower dose of nitroglycerin ointment and may gradually increase your dose as needed to control your angina. (medlineplus.gov)
  • Nitroglycerin ointment may not work as well after it has been used for some time, especially at higher doses. (medlineplus.gov)
  • Nitroglycerin ointment helps to prevent angina attacks but does not cure coronary artery disease. (medlineplus.gov)
  • Continue to use nitroglycerin ointment even if you feel well. (medlineplus.gov)
  • Do not stop using nitroglycerin ointment without talking to your doctor. (medlineplus.gov)
  • If you are using nitroglycerin ointment to prevent angina, follow your doctor's directions and the guidelines in this paragraph to apply the medication. (medlineplus.gov)
  • Nitroglycerin ointment comes with a paper applicator with a ruled line for measuring the dose (in inches). (medlineplus.gov)
  • Lay the covered finger alongside the 1 inch dosing line on the side of the nitroglycerin ointment box so that the tip of the finger is at one end of the dosing line. (medlineplus.gov)
  • If you are using nitroglycerin ointment to treat anal fissure pain, ask your pharmacist or doctor for a copy of the manufacturer's information for the patient. (medlineplus.gov)
  • What do I need to tell my doctor BEFORE I take Nitroglycerin Rectal Ointment? (drugs.com)
  • If you have an allergy to nitroglycerin or any other part of nitroglycerin rectal ointment. (drugs.com)
  • This is not a list of all drugs or health problems that interact with nitroglycerin rectal ointment. (drugs.com)
  • You must check to make sure that it is safe for you to take nitroglycerin rectal ointment with all of your drugs and health problems. (drugs.com)
  • What are some things I need to know or do while I take Nitroglycerin Rectal Ointment? (drugs.com)
  • Tell all of your health care providers that you take nitroglycerin rectal ointment. (drugs.com)
  • Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how nitroglycerin rectal ointment affects you. (drugs.com)
  • Avoid drinking alcohol while taking nitroglycerin rectal ointment. (drugs.com)
  • If you are 65 or older, use nitroglycerin rectal ointment with care. (drugs.com)
  • You will need to talk about the benefits and risks of using nitroglycerin rectal ointment while you are pregnant. (drugs.com)
  • How is this medicine (Nitroglycerin Rectal Ointment) best taken? (drugs.com)
  • Use nitroglycerin rectal ointment as ordered by your doctor. (drugs.com)
  • What are some other side effects of Nitroglycerin Rectal Ointment? (drugs.com)
  • Nitroglycerin ointment or skin patch is used to prevent angina (chest pain) caused by coronary artery disease. (mayoclinic.org)
  • Nitroglycerin rectal ointment is used to relieve moderate to severe pain caused by chronic anal fissures. (mayoclinic.org)
  • Application of a 0.2% nitroglycerin ointment may help heal a long-term (chronic) tear, or fissure , in the anus . (wellspan.org)
  • Headaches are the main side effect of nitroglycerin ointment. (wellspan.org)
  • In some cases, people may develop tolerance to nitroglycerin, meaning that after a while the ointment no longer works to reduce muscle tension. (wellspan.org)
  • People using nitroglycerin ointment have increased chances of having low blood pressure. (wellspan.org)
  • So you should not use nitroglycerin ointment within 24 hours of taking sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra). (wellspan.org)
  • Nitroglycerin (Intra-anal ointment) is a colorectal agent that is FDA approved for the treatment of moderate to severe pain associated with chronic anal fissure . (wikidoc.org)
  • RECTIV™ (nitroglycerin) Ointment 0.4% is indicated for the treatment of moderate to severe pain associated with chronic anal fissure . (wikidoc.org)
  • Apply 1 inch of ointment (375 mg of ointment equivalent to 1.5 mg of nitroglycerin) intra-anally every 12 hours for up to 3 weeks. (wikidoc.org)
  • There is limited information regarding Off-Label Guideline-Supported Use of Nitroglycerin (Intra-anal ointment) in adult patients. (wikidoc.org)
  • There is limited information regarding FDA labeled Use of Nitroglycerin (Intra-anal ointment) in pediatric patients. (wikidoc.org)
  • Nitroglycerin 2% ointment is applied above the compression surface on the skin, to evaluate its efficacy in reducing radial artery occlusion. (clinicaltrials.gov)
  • The use of topical nitroglycerin ointment to treat peripheral tissue ischemia secondary to arterial line complications in neonates," Journal of Perinatology , vol. 22, no. 5, pp. 416-419, 2002. (hindawi.com)
  • Nitroglycerin is a medicine that helps relax the blood vessels leading to the heart. (medlineplus.gov)
  • Nitroglycerin works by relaxing the smooth muscle and blood vessels in your body. (healthline.com)
  • Shortly after heart patients take nitroglycerin, the blood vessels supplying the heart muscle relax, allowing oxygen-rich blood to nourish the heart and relieve the pain. (emaxhealth.com)
  • The research team led by Jonathan Stamler, M.D., HHMI investigator at Duke, found an enzyme that not only breaks down nitroglycerin and releases a nitric oxide-related molecule, but whose action is suppressed in blood vessels made tolerant after repeated doses of nitroglycerin. (emaxhealth.com)
  • Nitroglycerin is a vasodilator, a medicine that opens blood vessels to improve blood flow. (cardiosmart.org)
  • Nitroglycerin relaxes blood vessels allowing more blood to flow through and improves blood flow to the heart. (patientassistance.com)
  • Nitroglycerin is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump. (wellspan.org)
  • Nitroglycerin relieves acute angina attacks by relaxing blood vessels and increasing the oxygen and blood supply to the heart. (pharmasave.com)
  • Nitroglycerin, also known as glyceryl trinitrate (GTN), is a medication used for heart failure, high blood pressure, anal fissures, painful periods, and to treat and prevent chest pain caused by decreased blood flow to the heart (angina) or due to the recreational use of cocaine. (wikipedia.org)
  • Nitroglycerin also known as glyceryl trinitrate is a vasodilator used for rapid relief of chest pain or tightness associated with angina. (patientslikeme.com)
  • Spray bottle of the cardiac drug glyceryl trinitrate (GTN), also known as nitroglycerin. (sciencephoto.com)
  • Nitroglycerin is in the nitrate family of medications. (wikipedia.org)
  • Nitroglycerin sublingual tablets are a nitrate vasodilator indicated for relief of an attack or prophylaxis of angina pectoris due to coronary artery disease. (nih.gov)
  • Nitroglycerin, an organic nitrate, is a vasodilating agent. (nih.gov)
  • Nitroglycerin Skin Patches is a nitrate, prescribed for chest pain. (medindia.net)
  • Vitamin C may help prevent the development of tolerance to nitrate medications such as nitroglycerin. (portsmouthhospital.com)
  • If you develop chest pain and have taken one of these erection-enhancing medicines, be sure to tell your doctor so that you are not given nitroglycerin or another nitrate medicine. (cardiosmart.org)
  • Do not take the pulmonary hypertension medicine sildenafil (Revatio) if you are taking nitroglycerin or another nitrate medicine. (cardiosmart.org)
  • Nitroglycerin is cleared by glutathione-nitrate reductase, hydrolysis, direct removal by vasculature, and other less well-defined mechanisms. (oncologynurseadvisor.com)
  • Patients with obstructive hypertrophic cardiomyopathy, pronounced hypovolemia, STEMI or presumed cardiac chest pain, inferior myocardial infarction with right ventricular involvement, raised intracranial pressure, cardiac tamponade, and patients taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), pregnancy, or with a known allergy to nitroglycerin will be excluded from the study. (clinicaltrials.gov)
  • 2: Known allergy to nitroglycerin. (clinicaltrials.gov)
  • In medicine for over 130 years, nitroglycerin has been used as a potent vasodilator (dilation of the vascular system) to treat heart conditions, such as angina pectoris and chronic heart failure . (wikipedia.org)
  • Adverse reactions to nitroglycerin are generally dose-related, and almost all of these reactions are the result of nitroglycerin.s activity as a vasodilator. (rxlist.com)
  • NITROGLYCERIN (nye troe GLI ser in) is a type of vasodilator. (ahealthyme.com)
  • Intravenous nitroglycerin is a well-recognized treatment of acute hypertension and hypertensive encephalopathy. (ahajournals.org)
  • 1 We are reporting a patient presented with posterior reversible encephalopathy syndrome (PRES) secondary to hypertensive crisis who deteriorated when his blood pressure was treated with intravenous nitroglycerin. (ahajournals.org)
  • A brain computed tomography scan showed hypodensities in the white matter of posterior parietal lobes bilaterally ( Figure 1 A and 1 B). He was started on intravenous labetalol but then became bradycardic, so an intravenous nitroglycerin drip was initiated. (ahajournals.org)
  • Intravenous nitroglycerin was stopped. (ahajournals.org)
  • We assumed that the clinical and radiological deterioration was secondary to the intravenous nitroglycerine, because, in spite of gradual lowering of the blood pressure, his neurological deficit became markedly worse. (ahajournals.org)
  • 3 Treatment consists of acute blood pressure control using intravenous medications, including nitroglycerine, and patients who are promptly treated usually recover without deficit. (ahajournals.org)
  • Polyvinylchloride containers do not influence the hemodynamic response to intravenous nitroglycerin. (biomedsearch.com)
  • In each subject, the emptying of 300 ml of 25% glucose labeled with 99m Tc was assessed on two separate days during intravenous infusion of either nitroglycerin (5 μg/min in 5% dextrose) or 5% dextrose (control). (physiology.org)
  • Intravenous nitroglycerin for controlled cord traction in the management of retained placenta. (druglib.com)
  • OBJECTIVE: To determine the effect of 200 mug of intravenous nitroglycerin in the release of retained placenta by controlled cord traction. (druglib.com)
  • Intravenous nitroglycerin for external cephalic version: a randomized controlled trial. (druglib.com)
  • OBJECTIVE: To estimate whether treatment with intravenous nitroglycerin for uterine relaxation increases the chance of successful external cephalic version. (druglib.com)
  • CONCLUSION: Treatment with intravenous nitroglycerin increased the rate of successful external cephalic version in nulliparous, but not in multiparous, women. (druglib.com)
  • Treatment with intravenous nitroglycerin appeared to be safe, but our numbers were too small to rule out rare serious adverse effects. (druglib.com)
  • With intravenous, long-acting transdermal and long-acting transmucosal nitroglycerin recently available, we stand on the threshold of an era of rational, effective nitroglycerin prophylaxis. (annals.org)
  • Intravenous nitroglycerin is contraindicated in patients with these conditions. (americanregent.com)
  • Nitroglycerin readily migrates into many plastics, including the polyvinyl chloride (PVC) plastics commonly used for intravenous administration sets. (americanregent.com)
  • PVC tubing has been used in most published studies of intravenous nitroglycerin, but the reported doses have been calculated by simply multiplying the flow rate of the solution by the solution's original concentration of nitroglycerin. (americanregent.com)
  • A randomized clinical trial of intravenous nitroglycerin in patients with acute myocardial infarction: benefits of early treatment. (biomedsearch.com)
  • A prospective randomized clinical trial of intravenous nitroglycerin administered for 48 hours following acute infarction was undertaken to determine whether clinical improvement and/or preservation of ischemic myocardium could be demonstrated. (biomedsearch.com)
  • When you take nitroglycerin with certain drugs, nitroglycerin may not work as well to treat your condition. (healthline.com)
  • How should I take nitroglycerin? (uofmhealth.org)
  • This clinical trial is designed to evaluate the physiologic and molecular effects of inhaled NO and a currently available, safe, FDA-approved medication, nitroglycerin, that is a nitric oxide donor (i.e., a source of NO after metabolism in the body), in study subjects with and without sickle cell anemia. (clinicaltrials.gov)
  • The effects of the nitric oxide donor nitroglycerin on gastric emptying and antropyloroduodenal motility were evaluated in nine healthy male subjects (ages 19-36 yr). (physiology.org)
  • Nitroglycerin is a nitric oxide donor which is mainly known as a vasodilating agent used in ischemic heart disease. (druglib.com)
  • Following the discovery that amyl nitrite helped alleviate chest pain, the physician William Murrell experimented with the use of nitroglycerin to alleviate angina pectoris and to reduce the blood pressure. (wikipedia.org)
  • Nitroglycerin dilates veins, relieving chest pain and lowering blood pressure. (drugs.com)
  • Nitroglycerin sublingual tablet is used to stop or prevent angina (chest pain). (healthline.com)
  • Nitroglycerin is used to treat angina (chest pain). (healthline.com)
  • For more than 130 years, doctors have prescribed nitroglycerin for relief of chest pain without a clear knowledge of how it actually worked. (emaxhealth.com)
  • Nitroglycerin, first manufactured by the Swedish industrialist Alfred Nobel, is a common treatment for angina (chest pain) and heart failure. (emaxhealth.com)
  • Nitroglycerin transdermal (skin patch) is used to prevent attacks of chest pain ( angina ). (rxlist.com)
  • Nitroglycerin is used to treat chest pain (angina angina pectoris, also known as ischemic heart disease), and can also be used with other drugs to treat congestive heart failure and heart attacks. (citizendium.org)
  • Nitroglycerin reduces chest pain, but it does not cure the underlying causes. (citizendium.org)
  • Sublingual nitroglycerin is most commonly used for treatment of chest pain related to insufficient cardiac perfusion. (clinicaltrials.gov)
  • Topical nitroglycerin skin patches are used to prevent angina (chest pain). (patientassistance.com)
  • You should not use sublingual nitroglycerin if you have severe anemia, increased pressure inside your skull, circulation problems, chest pain that spreads to your jaw or shoulder, or signs of shock (pale skin, suddenly feeling light-headed). (uofmhealth.org)
  • Tolerance to nitroglycerin, a drug often used to treat chest pain, increases susceptibility to injury by myocardial infarction. (sciencemag.org)
  • Nitroglycerin is used for the treatment of angina, acute myocardial infarction, severe hypertension, and acute coronary artery spasms. (wikipedia.org)
  • Nitroglycerin sublingual tablets may be used prophylactically 5 minutes to 10 minutes prior to engaging in activities that might precipitate an acute attack. (nih.gov)
  • The onset of action of transdermal nitroglycerin is not sufficiently rapid for this product to be useful in aborting an acute attack. (rxlist.com)
  • Acute titration was done with nitroglycerin patches on the basis of weekly patient diaries on frequency of angina and sublingual nitroglycerin consumption. (nih.gov)
  • ABSTRACT: Sublingual nitroglycerin has been advocated for the treatment of acute pain from suspected symptomatic cholelithiasis. (clinicaltrials.gov)
  • This study is designed to evaluate the efficacy of nitroglycerine in relieving acute pain of suspected biliary tract origin. (clinicaltrials.gov)
  • Reduction of ischemic injury by sublingual nitroglycerin in patients with acute myocardial infarction. (ahajournals.org)
  • The effect of sublingual nitroglycerin (NTG) on myocardial ischemic injury was evaluated in eleven patients with acute anterior myocardial infarction. (ahajournals.org)
  • Evaluation performed by the technique of precordial ST-segment mapping suggests that sublingual nitroglycerin in a commonly employed clinical dose is associated with evidence of reduced ischemic cardiac injury in patients with acute myocardial infarction. (ahajournals.org)
  • Severity of contraction abnormalities after acute myocardial infarction in man: response to nitroglycerin. (ahajournals.org)
  • PubMed, EMBASE, the Cochrane Library and China National Knowledge Infrastructure were searched for randomized studies that compared urapidil treatment with nitroglycerin treatment for hypertensive patients with acute heart failure. (dovepress.com)
  • However, before routine administration of nitroglycerin can be recommended for all patients with acute infarction, larger clinical trials will be required. (biomedsearch.com)
  • Nitroglycerin therapy in acute myocardial infarction--an overview. (biomedsearch.com)
  • To help prevent this, your doctor will schedule your doses so that there is a period of time when you are not exposed to nitroglycerin every day. (medlineplus.gov)
  • He began treating his patients with small diluted doses of nitroglycerin in 1878, and this treatment was soon adopted into widespread use after Murrell published his results in the journal The Lancet in 1879. (wikipedia.org)
  • Therapeutic doses of nitroglycerin may reduce systolic, diastolic, and mean arterial blood pressure. (nih.gov)
  • 2. Methods: A convenience sample of patients presenting to the Emergency Department will be randomized to receive either sublingual 0.4 mg doses of nitroglycerin or placebo. (clinicaltrials.gov)
  • If relief is still not obtained after three doses of nitroglycerin (i.e., 15 minutes), seek medical help immediately. (pharmasave.com)
  • Nitroglycerin belongs to the group of medicines called nitrates. (mayoclinic.org)
  • Nitrates such as nitroglycerin lose some of their effectiveness over time. (portsmouthhospital.com)
  • in the sketchy video for nitrates, they say nitroglycerin is contraindicated in right side heart myocardial infarction. (studentdoctor.net)
  • What are the possible side effects of nitroglycerin transdermal? (rxlist.com)
  • Read the side effects of Nitroglycerin Skin Patches as described in the medical literature. (medindia.net)
  • The biological effects of nitroglycerin arise because, in the body, the breakdown-products of nitroglycerin include the gas nitric oxide . (citizendium.org)
  • Appropriate studies have not been performed on the relationship of age to the effects of nitroglycerin transdermal in the pediatric population. (mayoclinic.org)
  • Effects of nitroglycerin on central haemodynamics and VA/Q distribution early after coronary bypass surgery. (nih.gov)
  • Amplification of the vasodilatory effects of nitroglycerin by sildenafil can result in severe hypotension. (americanregent.com)
  • This led to a complete ban on the transportation of liquid nitroglycerin in California. (wikipedia.org)
  • Liquid nitroglycerin was widely banned elsewhere, as well, and these legal restrictions led to Alfred Nobel and his company's developing dynamite in 1867. (wikipedia.org)
  • Driving like you have liquid nitroglycerin next to you! (abovetopsecret.com)
  • Storage=== Never store liquid nitroglycerin, even for short periods! (sciencemadness.org)
  • The Transderm-Nitro (nitroglycerin) transdermal system is a flat unit designed to provide continuous controlled release of nitroglycerin through intact skin. (rxlist.com)
  • Nitroglycerin is rapidly absorbed following sublingual administration of Nitrostat tablets. (nih.gov)
  • Maximum plasma nitroglycerin concentrations (Cmax) and area under the plasma concentration-time curves (AUC) increase dose-proportionally following 0.3 to 0.6 mg Nitrostat. (nih.gov)
  • The absolute bioavailability of nitroglycerin from Nitrostat tablets is approximately 40% but tends to be variable due to factors influencing drug absorption such as sublingual hydration and mucosal metabolism. (nih.gov)
  • Nitroglycerin sublingual tablet is a prescription drug that's available as the brand-name drug Nitrostat. (healthline.com)
  • [4] Nitroglycerin is available in sublingual tablets , sprays, and patches. (wikipedia.org)
  • These highlights do not include all the information needed to use NITROGLYCERIN SUBLINGUAL TABLETS safely and effectively. (nih.gov)
  • See full prescribing information for NITROGLYCERIN SUBLINGUAL TABLETS. (nih.gov)
  • Administer nitroglycerin sublingual tablets at rest, preferably in the sitting position. (nih.gov)
  • Do not use nitroglycerin sublingual tablets in patients who are taking PDE-5 Inhibitors, such as avanafil, sildenafil, tadalafil, vardenafil hydrochloride. (nih.gov)
  • He went to his satchel again and took out a bottle of white tablets marked " Nitroglycerin . (thesaurus.com)
  • Nitronow, convenient storage tube to hold nitroglycerine tablets, sold individually. (restockit.com)
  • Venous and arterial dilatation as a consequence of nitroglycerin treatment including RECTIV, can decrease venous blood returning to the heart and reduce arterial vascular resistance and systolic pressure. (wikidoc.org)
  • Please describe the warnings of the use of nitrolingual (nitroglycerin) spray? (healthtap.com)
  • What are the risks of using nitrolingual (nitroglycerin) spray? (healthtap.com)
  • Why shouldn't you use nitrolingual (nitroglycerin) spray to relieve angina in cases of hypothyrodism? (healthtap.com)
  • I'm 17 can I take nitrolingual (nitroglycerin) pump spray? (healthtap.com)
  • What to do if I am 17 can I take nitrolingual (nitroglycerin) pump spray? (healthtap.com)
  • Can teens take nitrolingual (nitroglycerin) pumpspray if being checked for angina pain? (healthtap.com)
  • Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds. (nih.gov)
  • Elevated central venous and pulmonary capillary wedge pressures, and pulmonary and systemic vascular resistance are also reduced by nitroglycerin therapy. (nih.gov)
  • Different susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans. (portsmouthhospital.com)
  • group II patients had higher initial venous distensibility but did not respond to nitroglycerin. (portlandpress.com)
  • To improve blood flow to the heart, nitroglycerin opens up (dilates) the arteries in the heart ( coronary arteries ), which improves symptoms and reduces how hard the heart has to work. (cardiosmart.org)
  • Nitroglycerin (as a medicine) comes in the form of a sublingual tablet, buccal tablet, extended-release (long-acting) capsule, or oral spray. (citizendium.org)
  • McGowan(1936), Chelly (1979),Toyoyama (2001)] The typical dose of nitroglycerin is 0.4 mg given sublingually in pill form or, more recently, in a metered spray form. (clinicaltrials.gov)
  • For sudden episodes of angina, use nitroglycerin in a tablet or liquid spray form. (cardiosmart.org)
  • Keep nitroglycerin pills and liquid spray away from heat and moisture. (cardiosmart.org)
  • While using nitroglycerin spray, remain at rest in a sitting position and keep the container vertical with the nozzle head up. (pharmasave.com)
  • Store nitroglycerin spray at room temperature (15°C to 30°C) away from hot water, radiators, or other sources of heat. (pharmasave.com)
  • The spray form of nitroglycerine has a very rapid onset of action. (healthtap.com)
  • Is nitroglycerin spray ever used for anything other than angina? (healthtap.com)
  • Is it possible that the nitroglycerin spray affect the breathing test for alcohol? (healthtap.com)
  • A nitroglycerin spray may last up to 2 years before it expires. (nkch.org)
  • Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease . (rxlist.com)
  • In vivo induction and reversal of nitroglycerin tolerance in human coronary arteries. (portsmouthhospital.com)
  • Nitroglycerin (NTG) induces delayed preconditioning (PC)-mimetic effects in animal models and in humans during coronary angioplasty. (nih.gov)
  • Central haemodynamics and ventilation-perfusion (VA/Q) distribution were studied in nine patients, 21 h after coronary bypass surgery, before and during nitroglycerin (TNG) infusion. (nih.gov)
  • Nitroglycerin also inhibits platelet aggregation, a potentially favorable property in the setting of occlusive coronary artery disease. (oncologynurseadvisor.com)
  • IV nitroglycerin may also improve coronary blood flow, myocardial perfusion, and energetics simply by dropping ventricular diastolic pressure greater than the fall in aortic diastolic pressure, thus allowing an augmentation of myocardial diastolic perfusion pressure. (oncologynurseadvisor.com)
  • It is not uncommon for IV nitroglycerin to lower heart rate by reducing dyspnea and related symptoms, such that there is also an increase in coronary perfusion time. (oncologynurseadvisor.com)
  • Lack of effect of nitroglycerin on the transmural variation of tissue pH during fixed coronary steno. (biomedsearch.com)
  • Now, not only have researchers from Howard Hughes Medical Institute (HHMI) and Duke University Medical Center solved this age-old riddle, they have also shed light on the second major mystery surrounding nitroglycerin, why patients eventually develop a tolerance to the drug's effects. (emaxhealth.com)
  • The results of this study "teaches us that mitochondrial aldehyde dehydrogenase is at least partially responsible for the bioactivation of nitroglycerin and is likely the target of nitroglycerin tolerance," writes Louis Ignarro, Ph.D., in an accompanying commentary in PNAS. (emaxhealth.com)
  • Moreover, by understanding the molecular mechanism of nitroglycerin bioactivation and tolerance, it may now be possible to design and develop novel nitrovasodilator drugs that do not cause tolerance. (emaxhealth.com)
  • Daily low-dose folic acid supplementation does not prevent nitroglycerin-induced nitric oxide synthase dysfunction and tolerance: a human in vivo study. (druglib.com)
  • INTRODUCTION: Continuous treatment with nitroglycerin (GTN) causes tolerance and endothelial dysfunction, both of which may involve endothelial nitric oxide synthase (eNOS) dysfunction. (druglib.com)
  • When nitroglycerin was initially formulated by Ascanio Sobrero in 1847, he quickly realized it was a highly explosive compound. (miningjournal.net)
  • Nitroglycerin Injection is contraindicated in patients who are allergic to it. (americanregent.com)
  • However, elderly patients are more likely to have low blood pressure and age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving nitroglycerin transdermal. (mayoclinic.org)
  • However, elderly patients are more likely to have unwanted effects such as lightheadedness, dizziness, or fainting, which may require caution and an adjustment in the dose for patients receiving nitroglycerin. (mayoclinic.org)
  • Similarly, thallium-201 perfusion scintigrams showed a greater than 75% improvement in defect score in 23 (48%) patients receiving nitroglycerin within 10 hours compared to 14%, 33% and 0% respectively, in the remaining subgroups (p = 0.035). (biomedsearch.com)
  • The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle. (nih.gov)
  • My heart stopped beating during tilt test for 8 seconds after being sprayed under my tongue with nitroglycerin. (healthtap.com)
  • Or you may feel burning or tingling under your tongue with nitroglycerin that is used under the tongue. (nkch.org)
  • Based on the current evidence, urapidil treatment had better clinical safety features than the traditional pharmaceutical treatment with nitroglycerin. (dovepress.com)
  • Read user comments about the side effects, benefits, and effectiveness of nitroglycerin translingual. (webmd.com)
  • According to a double-blind study of 48 individuals, use of vitamin C at a dose of 2000 mg three times daily helped maintain the effectiveness of nitroglycerin. (portsmouthhospital.com)
  • Facilitation of radial artery cannulation by periradial subcutaneous administration of nitroglycerin. (druglib.com)
  • PURPOSE: To determine whether subcutaneous administration of nitroglycerin mixed with local anesthetic agent results in effective vasodilation of the radial artery, and whether this technique improves access time and decreases complications. (druglib.com)
  • CONCLUSIONS: Subcutaneous administration of nitroglycerin significantly increased radial artery diameter, which can lead to facilitation of catheterization of the radial artery for arteriography and interventions. (druglib.com)
  • Patients with right upper quadrant abdominal pain of less than 24 hour duration between ages 18 and 60 years of age will be offered treatment with sublingual nitroglycerin or placebo. (clinicaltrials.gov)
  • The medication will be either a 0.4 mg dose of nitroglycerin or a placebo. (clinicaltrials.gov)
  • Measurements in study subjects will be made prior to and while receiving either NO, nitroglycerin, or placebo. (clinicaltrials.gov)
  • A randomized comparison of topical nitroglycerin versus placebo gel for prevention of radial artery occlusion after transradial catheterization. (clinicaltrials.gov)
  • One hundred four patients were randomized to receive either nitroglycerin or placebo infusion. (biomedsearch.com)
  • Early nitroglycerin treatment, defined as treatment initiated less than 10 hours after symptom onset, resulted in a lower incidence of new congestive heart failure, myocardial infarct extension, and/or early death from pump failure (15%) compared to late nitroglycerin treatment (50%, p = 0.008) or early placebo treatment (48%, p = 0.01). (biomedsearch.com)
  • Nitroglycerin was later adopted as a commercially useful explosive by Alfred Nobel , who experimented with safer ways to handle the dangerous compound after his younger brother, Emil Oskar Nobel , and several factory workers were killed in an explosion at the Nobels' armaments factory in 1864 in Heleneborg , Sweden. (wikipedia.org)
  • A few months before his death in 1896, Alfred Nobel was prescribed nitroglycerin for this heart condition, writing to a friend: "Isn't it the irony of fate that I have been prescribed nitro-glycerin, to be taken internally! (wikipedia.org)
  • While Sobrero washed his hands of the dangerous compound after writing up his findings, Alfred Nobel, a young mechanical engineer, read Sobrero's findings on nitroglycerin. (miningjournal.net)
  • Do not wear more than one nitroglycerin transdermal patch at a time. (rxlist.com)
  • Do not take the erection-enhancing medicines sildenafil (Viagra), vardenafil (Levitra), or tadalafil (Cialis) if you are taking nitroglycerin. (cardiosmart.org)
  • People who use nitroglycerin regularly or intermittently should not use phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, or vardenafil) because a life-threatening lowering of blood pressure can result. (pharmasave.com)
  • Repaglinide and hearing loss of the how many times can you give nitroglycerin cause hypothyroidism can be confused with antimicrobial substances. (imagenenaccion.org)
  • Trials how many times can you give nitroglycerin with regard to initiate intracellular enzymes, with recurrent fistulas. (imagenenaccion.org)
  • Nitroglycerin was the first practical explosive produced that was stronger than black powder . (wikipedia.org)
  • In April 1866, three crates of nitroglycerin were shipped to California for the Central Pacific Railroad, which planned to experiment with it as a blasting explosive to expedite the construction of the 1,659-foot-long (506 m) Summit Tunnel through the Sierra Nevada Mountains. (wikipedia.org)
  • The drug nitroglycerin (GTN) is a dilute form of the same chemical used as the explosive, nitroglycerin. (wikipedia.org)
  • Nitroglycerin was then thought much too dangerous to be useful, despite its considerable explosive power, but Nobel became interested in how it might be made safe to handle. (citizendium.org)
  • The 1878 explosion had occurred on a railroad siding near Negaunee, where employees of the Lake Superior Nitroglycerin Company were loading 4,800 pounds of nitroglycerin, a notoriously unstable and dangerous explosive, into a train car destined for the Republic Mine. (miningjournal.net)
  • Sobrero recognized there was a tremendous need for a powerful explosive like nitroglycerin, as the industrial revolution was rapidly increasing the demand for mining products. (miningjournal.net)
  • Sobrero had discovered nitroglycerin was highly unstable and explosive around its freezing point - 39 degrees Fahrenheit. (miningjournal.net)
  • In fact, local mines began using nitroglycerin around two years after Nobel's 1867 invention of dynamite, which was a safer explosive that overcame "many disadvantages of nitroglycerin," said Van Kosky. (miningjournal.net)
  • The details of events leading up to the explosion were hotly contended, but the two living witnesses of the event reported observing "careless and negligent handling of the explosive by employees of the Lake Superior Nitroglycerin Company," Van Kosky said. (miningjournal.net)
  • For the use of this chemical as a drug, see Nitroglycerin (drug) . (wikipedia.org)
  • Nitroglycerin sublingual tablet is available as both a generic and a brand-name drug. (healthline.com)
  • Nitroglycerin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine ). (citizendium.org)
  • Nitroglycerin - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine ). (citizendium.org)
  • This study is designed to evaluate the effects of NO, when taken in combination with a drug called nitroglycerin on patients with sickle cell anemia and normal volunteers. (clinicaltrials.gov)
  • Fahmy, N. R. (1978) Nitroglycerin as a hypotensive drug during general anesthesia. (springer.com)
  • Nitroglycerin (NTG), a drug that has been in clinical use for more than a century, has a range of actions which make it of particular interest in an oncological setting. (ecancer.org)
  • Intravenously administered nitroglycerin has several applications in clinical medicine (e.g., unstable angina, symptomatic heart failure), but we will focus on its use in heart failure. (oncologynurseadvisor.com)
  • CONCLUSION: Intravenously administered nitroglycerin did not facilitate the release of retained placenta by umbilical cord traction. (druglib.com)
  • Gillis, R. A., Melville, K. I. (1971) Effects of sublingually and intravenously administered nitroglycerin on the cardiovascular system of the dog. (springer.com)
  • Quick-acting forms of nitroglycerin are used to relieve angina or used just before activities that typically cause angina. (cardiosmart.org)
  • The purpose of this research study is to test the safety, tolerability, and effectiveness of Topical AmphiMatrix with Nitroglycerin (MQX0503) to relieve Raynaud's symptoms and increase blood flow to the fingers. (clinicaltrials.gov)
  • Nitroglycerin transdermal may also be used for purposes not listed in this medication guide. (rxlist.com)
  • Nitroglycerin effect is a result of the nitric oxide component of the medication which acts as a smooth muscle relaxant in vascular, bronchial, esophageal and biliary smooth muscles. (clinicaltrials.gov)
  • Nitroglycerin is commonly used for heat medication, so some people with angina carry a small amount of it with them. (thenakedscientists.com)
  • You should not use nitroglycerin if you are allergic to it, or if you are using medicine to treat pulmonary arterial hypertension, such as riociguat (Adempas). (uofmhealth.org)
  • IV nitroglycerin reduces left ventricular diastolic pressure, pulmonary capillary wedge pressure, right ventricular diastolic pressure and right atrial pressure. (oncologynurseadvisor.com)
  • Supplementation of Bier's block with transcutaneous nitroglycerin patch reduces the lidocaine dose, the sensory and motor block onset times, VAS scores, and analgesic consumption intra- and postoperatively. (hindawi.com)
  • Effect of nitroglycerin in patients with increased pulmonary vascular resistance undergoing cardiac transplantation. (nih.gov)
  • The purpose of this study was to follow changes in pulmonary haemodynamics in patients with pulmonary hypertension undergoing heart transplantation, and to examine whether postoperative changes can be predicted from a preoperative nitroglycerin (NTG) challenge. (nih.gov)
  • See the full nitroglycerin side effects document. (drugs.com)
  • The results of this study should make it much easier for researchers to design new studies whose goals would be to maximize the benefits of nitroglycerin and lessen its side effects. (emaxhealth.com)
  • While researchers in the past have searched for such an enzyme in different tissues, the Duke team found that the biochemical reaction that breaks down nitroglycerin takes place in mitochondria, a compartment within cells commonly known as the cell's "powerhouse. (emaxhealth.com)
  • Nitroglycerin (NTG) is one of the most commonly used treatments for quick relief of anginal pain. (portsmouthhospital.com)
  • N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses. (portsmouthhospital.com)
  • I began to be thoroughly frightened, and wormed out of her the fact that she had a terrible nitroglycerin headache. (thesaurus.com)
  • You may get a headache when you use nitroglycerin. (nkch.org)
  • Invented in 1847, nitroglycerin has been used as an active ingredient in the manufacture of explosives , mostly dynamite , and as such it is employed in the construction , demolition , and mining industries. (wikipedia.org)
  • Similar mixtures, such as "dualine" (1867), "lithofracteur" (1869), and "gelignite" (1875), were formed by mixing nitroglycerin with other inert absorbents, and many combinations were tried by other companies in attempts to get around Nobel's tightly held patents for dynamite. (wikipedia.org)
  • It is used in medicine and in the manufacture of the explosives nitroglycerin and dynamite. (thesaurus.com)
  • Dynamite, which consists of nitroglycerin mixed with diatomite, is much more stable, though over time the dynamite will "sweat" or "weep" its nitroglycerin, which can then pool in the bottom of the box or storage area and can explode. (sciencemadness.org)
  • In this trial we would like to demonstrate the effect of nitroglycerin on tumor perfusion and hypoxia in non small cell lung cancer (using DCE and HX4 scanning), providing a rationale for further study and to test the effect of combining nitroglycerine to standard treatment of NSCLC (radiotherapy/chemotherapy). (druglib.com)
  • In conclusion, the present study demonstrates that individual dose titration with nitroglycerin patches for obtaining significant antianginal effect is essential. (nih.gov)
  • On June 15, 2017, Advanced Pharma, Inc. d/b/a Avella of Houston announced it is voluntarily recalling all unexpired lots of nitroglycerin products produced at its Houston location from March 3, 2017-May 31, 2017 to the hospital level. (biopharminternational.com)