AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Nitric Oxide Synthase Type IINitric Oxide SynthaseFatty Acid Synthase, Type IINitric OxideNitric Oxide Synthase Type INitric Oxide Synthase Type IIIAmino Acid OxidoreductasesNG-Nitroarginine Methyl EsterNitric Oxide DonorsArginineEnzyme InhibitorsNitritesomega-N-MethylarginineEndothelium, VascularNitratesNitroarginineRats, Sprague-DawleyEnzyme InductionCyclic GMPNADPH DehydrogenaseVasodilationCells, CulturedRNA, MessengerIndazolesRats, WistarLipopolysaccharidesNitroprussideCitrullineS-Nitroso-N-AcetylpenicillamineBiopterinIsothiuroniumPenicillamineGuanidinesDose-Response Relationship, DrugMice, Inbred C57BLVasodilator AgentsNitrogen OxidesCitrate (si)-SynthaseMice, KnockoutGene Expression Regulation, EnzymologicImmunohistochemistryMacrophagesBlotting, WesternGuanylate CyclaseAortaSuperoxidesIsoenzymesAmidinesArginasePeroxynitrous AcidDisease Models, AnimalMolsidomineBlood PressureCyclooxygenase 2Time FactorsEndothelial CellsAcetylcholineProstaglandin-Endoperoxide SynthasesMolecular Sequence DataOxidative StressEnzyme ActivationSignal TransductionInterferon-gammaTumor Necrosis Factor-alphaGlycogen SynthaseGlycogen Synthase Kinase 3Cell LineOxidesVasoconstrictionS-NitrosoglutathioneInterleukin-1Thymidylate SynthaseCollagen Type IIMuscle, Smooth, VascularCattlePenisLungNF-kappa BReverse Transcriptase Polymerase Chain ReactionRegional Blood FlowOxadiazolesCyclooxygenase InhibitorsS-NitrosothiolsReactive Oxygen SpeciesNitrosationGTP CyclohydrolaseThioureaFree Radical ScavengersGene ExpressionAorta, ThoracicPhosphorylationIndomethacinReactive Nitrogen SpeciesMyocardium
Nitric Oxide Synthase Type II
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
Nitric Oxide Synthase
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Fatty Acid Synthase, Type II
The form of fatty acid synthase complex found in BACTERIA; FUNGI; and PLANTS. Catalytic steps are like the animal form but the protein structure is different with dissociated enzymes encoded by separate genes. It is a target of some ANTI-INFECTIVE AGENTS which result in disruption of the CELL MEMBRANE and CELL WALL.
Nitric Oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Nitric Oxide Synthase Type I
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE TISSUE.
Nitric Oxide Synthase Type III
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
Amino Acid Oxidoreductases
A class of enzymes that catalyze oxidation-reduction reactions of amino acids.
NG-Nitroarginine Methyl Ester
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
Nitric Oxide Donors
A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)
Arginine
An essential amino acid that is physiologically active in the L-form.
Enzyme Inhibitors
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Nitrites
Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
omega-N-Methylarginine
A competitive inhibitor of nitric oxide synthetase.
Endothelium, Vascular
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Nitrates
Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Nitroarginine
An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)
Rats, Sprague-Dawley
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Enzyme Induction
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
Cyclic GMP
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
NADPH Dehydrogenase
A flavoprotein that reversibly oxidizes NADPH to NADP and a reduced acceptor. EC 1.6.99.1.
Vasodilation
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Indazoles
Rats, Wistar
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Lipopolysaccharides
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Nitroprusside
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
Citrulline
S-Nitroso-N-Acetylpenicillamine
A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.
Biopterin
A natural product that has been considered as a growth factor for some insects.
Isothiuronium
An undecenyl THIOUREA which may have topical anti-inflammatory activity.
Penicillamine
3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
Guanidines
A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Mice, Inbred C57BL
Vasodilator Agents
Drugs used to cause dilation of the blood vessels.
Nitrogen Oxides
Inorganic oxides that contain nitrogen.
Citrate (si)-Synthase
Enzyme that catalyzes the first step of the tricarboxylic acid cycle (CITRIC ACID CYCLE). It catalyzes the reaction of oxaloacetate and acetyl CoA to form citrate and coenzyme A. This enzyme was formerly listed as EC 4.1.3.7.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Gene Expression Regulation, Enzymologic
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
Immunohistochemistry
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Blotting, Western
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Guanylate Cyclase
An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.
Aorta
The main trunk of the systemic arteries.
Superoxides
Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.
Isoenzymes
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
Amidines
Arginase
A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes HYPERARGININEMIA. EC 3.5.3.1.
Peroxynitrous Acid
A potent oxidant synthesized by the cell during its normal metabolism. Peroxynitrite is formed from the reaction of two free radicals, NITRIC OXIDE and the superoxide anion (SUPEROXIDES).
Disease Models, Animal
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Molsidomine
A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
Blood Pressure
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Cyclooxygenase 2
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Endothelial Cells
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Acetylcholine
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Prostaglandin-Endoperoxide Synthases
Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Oxidative Stress
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Enzyme Activation
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Glycogen Synthase
An enzyme that catalyzes the transfer of D-glucose from UDPglucose into 1,4-alpha-D-glucosyl chains. EC 2.4.1.11.
Glycogen Synthase Kinase 3
A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Oxides
Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.
Vasoconstriction
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
S-Nitrosoglutathione
A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.
Interleukin-1
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
Thymidylate Synthase
An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.
Collagen Type II
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
Muscle, Smooth, Vascular
The nonstriated involuntary muscle tissue of blood vessels.
Cattle
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Penis
The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.
Lung
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
NF-kappa B
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
Reverse Transcriptase Polymerase Chain Reaction
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Regional Blood Flow
The flow of BLOOD through or around an organ or region of the body.
Oxadiazoles
Cyclooxygenase Inhibitors
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
S-Nitrosothiols
A group of organic sulfur-containing nitrites, alkyl thionitrites. S-Nitrosothiols include compounds such as S-NITROSO-N-ACETYLPENICILLAMINE and S-NITROSOGLUTATHIONE.
Reactive Oxygen Species
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Nitrosation
Conversion into nitroso compounds. An example is the reaction of nitrites with amino compounds to form carcinogenic N-nitrosamines.
GTP Cyclohydrolase
(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
Thiourea
A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.
Free Radical Scavengers
Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.
Gene Expression
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Aorta, Thoracic
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
Phosphorylation
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Indomethacin
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
Reactive Nitrogen Species
Nitrogenous products of NITRIC OXIDE synthases, ranging from NITRIC OXIDE to NITRATES. These reactive nitrogen intermediates also include the inorganic PEROXYNITROUS ACID and the organic S-NITROSOTHIOLS.
Myocardium
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.

Inducible NO synthase: role in cellular signalling. (1/5912)

The discovery of endothelium-derived relaxing factor and its identification as nitric oxide (NO) was one of the most exciting discoveries of biomedical research in the 1980s. Besides its potent vasodilatory effects, NO was found under certain circumstances to be responsible for the killing of microorganisms and tumour cells by activated macrophages and to act as a novel, unconventional type of neurotransmitter. In 1992, Science picked NO as the 'Molecule of the Year', and over the past years NO has become established as a universal intercellular messenger that acutely affects important signalling pathways and, on a more long-term scale, modulates gene expression in target cells. These actions will form the focus of the present review.  (+info)

Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. (2/5912)

The two genetically established antimicrobial mechanisms of macrophages are production of reactive oxygen intermediates by phagocyte oxidase (phox) and reactive nitrogen intermediates by inducible nitric oxide synthase (NOS2). Mice doubly deficient in both enzymes (gp91(phox-/-)/NOS2(-/-)) formed massive abscesses containing commensal organisms, mostly enteric bacteria, even when reared under specific pathogen-free conditions with antibiotics. Neither parental strain showed such infections. Thus, phox and NOS2 appear to compensate for each other's deficiency in providing resistance to indigenous bacteria, and no other pathway does so fully. Macrophages from gp91(phox-/-)/NOS2(-/-) mice could not kill virulent Listeria. Their killing of S. typhimurium, E. coli, and attenuated Listeria was markedly diminished but demonstrable, establishing the existence of a mechanism of macrophage antibacterial activity independent of phox and NOS2.  (+info)

Role of nitric oxide in lipopolysaccharide-induced hepatic injury in D-galactosamine-sensitized mice as an experimental endotoxic shock model. (3/5912)

The role of nitric oxide (NO) in lipopolysaccharide (LPS)-induced hepatic injury was studied in D-galactosamine (D-GalN)-sensitized mice. The inducible isoform of NO synthase (iNOS) was immunohistochemically detected on hepatocytes around blood vessels in livers of mice injected with D-GalN and LPS not on hepatocytes in mice injected with D-GalN or LPS alone, although mRNA for iNOS was found in those mice. Nitrotyrosine (NT) was also found in livers of mice injected with D-GalN and LPS. The localization of NT was consistent with that of iNOS, and the time courses of NT and iNOS expression were almost the same. Expression of iNOS and NT was detected exclusively in the hepatic lesions of mice injected with D-GalN and LPS. Anti-tumor necrosis factor alpha neutralizing antibody inhibited iNOS and NT expression and hepatic injury. The results suggested that NO from iNOS may play a role in LPS-induced hepatic injury on D-GalN-sensitized mice as an experimental endotoxic shock model.  (+info)

Gamma interferon stimulates rat alveolar macrophages to kill Pneumocystis carinii by L-arginine- and tumor necrosis factor-dependent mechanisms. (4/5912)

Pneumocystis carinii pneumonia remains a serious complication for immunocompromised patients. In the present study, P. carinii organisms interacted with gamma interferon (IFN-gamma)-stimulated alveolar macrophages (AMs) to activate the L-arginine-dependent cytocidal pathway involving reactive nitrogen intermediates (RNI) that were assayed as nitrite (NO2-). Unstimulated cultures of AMs produced negligible quantities of RNI. Addition of P. carinii organisms to IFN-gamma-primed AMs resulted in greatly enhanced production of RNI. NO2- levels increased from 0.8 +/- 0.4 to 11.1 +/- 3.8 microM as early as 6 h after P. carinii organisms were incubated with IFN-gamma-stimulated AMs and to 35.1 +/- 8.9 microM after a 24-h incubation, a near-maximum level. High levels of NO2- were produced by AMs primed with as little as 10 U of IFN-gamma per ml in the presence of P. carinii, and a 20-fold increase in IFN-gamma concentration resulted in only a further 65% increase in NO2- production. RNI-dependent killing of P. carinii was demonstrated by both a 51Cr release assay and a [35S]methionine pulse immunoprecipitation assay. Addition of either monoclonal tumor necrosis factor alpha (TNF-alpha) neutralizing antibody or 200 microM NG-monomethyl-L-arginine (L-NGMMA), a competitive inhibitor of the L-arginine-dependent pathway, significantly decreased NO2- production and reduced P. carinii killing. TNF-alpha alone had no effect on P. carinii viability. These results suggest that (i) the specific interaction of P. carinii organisms with IFN-gamma-primed AMs triggers the production of RNI, (ii) RNI are toxic to P. carinii, and (iii) TNF-alpha likely plays a central role in mediating P. carinii killing by IFN-gamma-stimulated AMs.  (+info)

Effect of transforming growth factor beta on experimental Salmonella typhimurium infection in mice. (5/5912)

We have investigated the effect of the in vivo administration of recombinant transforming growth factor beta (rTGF-beta) on the pathogenic mechanisms involved in Salmonella typhimurium experimental infection in mice. The protective response elicited by macrophages was induced by rTGF-beta1 by 2 days after experimental infection, as demonstrated by an increased NO production, while the humoral protective effect began with cytokine mRNA expression 2 days after the challenge and continued after 5 days with cytokine release and lymphocyte activation. We demonstrated that all mice who received rTGF-beta1 survived 7 days after infection. The number of bacteria recovered in the spleens and in the livers of rTGF-beta1-treated mice 2 and 5 days after infection was significantly smaller than that found in the same organs after phosphate-buffered saline (PBS) inoculation. Furthermore, 2 and 5 days after infection, splenic macrophages from rTGF-beta1-treated mice showed a greater NO production than did those from PBS-treated mice. The effect of rTGF-beta1 on S. typhimurium infection in mice was correlated with the expression of cell costimulatory CD28 molecules. Five days after S. typhimurium infection, the percentage of CD28(+)-expressing T cells in splenic lymphocytes from rTGF-beta1-treated mice increased with respect to that from control mice. Gamma interferon (IFN-gamma) mRNA was present in a greater amount in spleen cells from rTGF-beta1-treated mice after 2 days, although the intensity of the band decreased 5 days after the challenge. A similar pattern was obtained with the mRNAs for interleukin-1alpha (IL-1alpha), IL-6, TGF-beta, and inducible nitric oxide synthase, which showed greater expression in cells obtained from rTGF-beta1-treated and S. typhimurium-infected mice 2 days after challenge. The treatment with rTGF-beta1 induced an increase in IL-1alpha and IFN-gamma release in the supernatant of splenocyte cultures 5 days after the experimental infection with S. typhimurium. Moreover, we demonstrated that 5 days after infection, the IFN-gamma titer was significantly greater in the sera of rTGF-beta-treated mice than in those of PBS-treated mice. Also, hsp60 showed greater expression 2 days after the challenge in splenocytes from rTGF-beta1-treated mice. The role played by proinflammatory and immunoregulatory cytokines and by CD28 is discussed.  (+info)

Nitric oxide in the endometrium. (6/5912)

Nitric oxide (NO) is an important mediator of paracrine interactions, especially within the vascular system. It is a powerful inhibitor of platelet aggregation and a potent vasodilator. NO is also a neurotransmitter and it plays a role in cell-mediated cytotoxicity. NO-generating enzymes (nitric oxide synthases, NOS) have been described in the endometrium of a number of species, suggesting that NO might be involved in endometrial function. In human endometrium, endothelial NOS and inducible NOS have been localized to glandular epithelium in the non-pregnant uterus. Weak inducible NOS immunoreactivity has been observed in decidualized stromal cells. NO might participate in the initiation and control of menstrual bleeding. Furthermore, it may play a part in the inhibition of platelet aggregation within the endometrium, where menstrual haemostasis is thought to occur primarily by vasoconstriction rather than clot organization. Endometrially derived NO could also suppress myometrial contractility. Recent attention has focused on the part that NO might play in maintaining myometrial quiescence during pregnancy. NO also appears to relax the non-pregnant myometrium, an action which could be exploited for the medical treatment of primary dysmenorrhoea.  (+info)

The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice. (7/5912)

Nitric oxide has multiple physiologic roles in the CNS. Inhibiting nitric oxide synthesis might therefore alter functional activity within the brain. We used [14C]-2-deoxyglucose in vivo autoradiography to measure local CMRglc in "knockout" mice lacking the genes for either the endothelial (eNOS) or neuronal (nNOS) isoforms of nitric oxide synthase, and in the progenitor strains (SV129, C57B1/6). Glucose utilization levels did not significantly differ between nNOS and eNOS knockout mice and C57B1/6 mice in any of the 48 brain regions examined, but were relatively lower in some subcortical regions in SV129 mice.  (+info)

Impairment of neocortical long-term potentiation in mice deficient of endothelial nitric oxide synthase. (8/5912)

The role of the possible retrograde messenger nitric oxide (NO) in the induction of long-term potentiation (LTP) was studied in supragranular layers of somatosensory cortical slices obtained from adult mice. High-frequency stimulation produced a slowly rising, long-lasting (50 min) and significant (P < 0.001) increase in the extracellular synaptic response by 23%. The induction of LTP was independent from activation of N-methyl-D-aspartate (NMDA) receptors, but prevented by bath application of NG-nitro-L-arginine methyl ester (L-NAME), indicating that one or several of the different NO synthases (NOS) produced NO within the postsynaptic neuron. No LTP could be induced in knockout mice lacking the endothelial NOS (eNOS) isoform. These data suggest that eNOS is involved in an NMDA receptor-independent form of LTP in the rodent cerebral cortex.  (+info)

AID 92143 - Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme. - PubChemAID 92143 - Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme. - PubChem
BioAssay record AID 92143 submitted by ChEMBL: Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme..
https://pubchem.ncbi.nlm.nih.gov/bioassay/92143
Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice<...Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice<...
TY - JOUR. T1 - Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice. AU - Micci, Maria Adelaide. AU - Kahrig, Kristen M.. AU - Simmons, Rochelle S.. AU - Sarna, Sushil K.. AU - Espejo-Navarro, M. Rosario. AU - Pasricha, Pankaj Jay. PY - 2005/12. Y1 - 2005/12. N2 - Background & Aims: Nitric oxide is a major inhibitory neurotransmitter in the enteric nervous system. Loss or dysfunction of nitrinergic neurons is associated with serious disruptions of motility, intractable symptoms, and long-term suffering. The aim of this study was to evaluate the effect of intrapyloric transplantation of neural stem cells (NSCs) on gastric emptying and pyloric function in nNOS-/- mice, a well-established genetic model of gastroparesis. Methods: NSCs were isolated from embryonic mice transgenically engineered to express green fluorescent protein and transplanted into the pylorus of nNOS-/- mice. Grafted cells were visualized in pyloric sections ...
https://researchexperts.utmb.edu/en/publications/neural-stem-cell-transplantation-in-the-stomach-rescues-gastric-f
A bi-allelic tetranucleotide repeat in the promoter of the human inducible nitric oxide synthase gene - Wellcome Centre for...
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https://www.well.ox.ac.uk/publications/36117
Inducible Nitric Oxide Synthase Expression and Luteal Cell DNA Fragmentation of Porcine Cyclic Corpora Lutea | Korea ScienceInducible Nitric Oxide Synthase Expression and Luteal Cell DNA Fragmentation of Porcine Cyclic Corpora Lutea | Korea Science
Inducible Nitric Oxide Synthase Expression and Luteal Cell DNA Fragmentation of Porcine Cyclic Corpora Lutea - Nitric Oxide Synthase;Corpora Lutea;Apoptosis;Estrous Cycle;
http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=E1DMBP_2005_v18n5_626
Thrombin induces inducible nitric oxide synthase expression via Ras, Raf-1, ERK, and NF-B signaling pathways in NR8383 lung...
TY - CONF. T1 - Thrombin induces inducible nitric oxide synthase expression via Ras, Raf-1, ERK, and NF-B signaling pathways in NR8383 lung macrophages. AU - Chen, Bing-Chang. AU - Chi, C.Y.. AU - Lin, Chien-Huang. PY - 2010/6/26. Y1 - 2010/6/26. M3 - Poster. Y2 - 26 June 2010 through 1 July 2010. ER - ...
https://tmu.pure.elsevier.com/zh/publications/thrombin-induces-inducible-nitric-oxide-synthase-expression-via-r
Impaired Wound Healing In Corneal Stroma Of A Nitric Oxide Synthase Type II -deficient Mouse | IOVS | ARVO JournalsImpaired Wound Healing In Corneal Stroma Of A Nitric Oxide Synthase Type II -deficient Mouse | IOVS | ARVO Journals
Purpose: To investigate the effects of loss of nitric oxide synthase type II (NOS2) in the healing of an injured corneal stroma in mice. Cell culture experiments were also conducted to clarify the effects of lacking NOS2 on ocular fibroblast gene expression.. Methods: The effect of lacking NOS2 on corneal stroma wound healing following an incision injury was evaluated by using NOS2-null (KO) mice. Histological, immunohistochemical and mRNA expression analyses were performed. Ocular fibroblasts from wild type (WT) and KO mice were used to study the role of NOS2 on fibrogenic gene expression.. Results: Healing of an incision injury in corneal stroma was delayed with less invasion of macrophages and reduction in expression of aSMA and fibronectin in a KO mouse as compared with a WT mouse. In vitro experiments showed that the loss of NOS2 suppressed mRNA expression of TGFb1 and collagen Ia1, but not MCP-1, in ocular fibroblasts. Being inconsistent with the in vivo finding, lacking NOS2 upregulated ...
http://iovs.arvojournals.org/article.aspx?articleid=2148694
High nitric oxide production, secondary to inducible nitric oxide synthase expression, is essential for regulation of the...High nitric oxide production, secondary to inducible nitric oxide synthase expression, is essential for regulation of the...
Chronic inflammation is a leading cause of neoplastic transformation in many human cancers and especially in colon cancer (CC), in part due to tumour promotion by nitric oxide (NO) generated at inflammatory sites. It has also been suggested that high NO synthesis, secondary to inducible NO synthase (iNOS) expression, is a distinctive feature of cancer stem cells (CSCs), a small subset of tumour cells with self-renewal capacity. In this study we explored the contribution of NO to the development of colon CSC features and evaluated potential strategies to treat CC by modulating NO production. Our data show an integral role for endogenous NO and iNOS activity in the biology of colon CSCs. Indeed, colon CSCs with high endogenous NO production (NO(high)) displayed higher tumourigenic abilities than NO(low) fractions. The blockade of endogenous NO availability, using either a specific iNOS inhibitor or a genetic knock-down of iNOS, resulted in a significant reduction of colon CSC tumourigenic ...
https://publicatt.unicatt.it/handle/10807/78271
Rapamycin inhibits lipopolysaccharide induction of granulocyte-colony stimulating factor and inducible nitric oxide synthase...
TY - JOUR. T1 - Rapamycin inhibits lipopolysaccharide induction of granulocyte-colony stimulating factor and inducible nitric oxide synthase expression in macrophages by reducing the levels of octamer-binding factor-2. AU - Chou, Yuan Yi. AU - Gao, Jhen I.. AU - Chang, Shwu Fen. AU - Chang, Po Yuan. AU - Lu, Shao Chun. PY - 2011/1. Y1 - 2011/1. N2 - This article reports an inhibitory effect of rapamycin on the lipopolysaccharide (LPS)-induced expression of both inducible nitric oxide synthase (iNOS) and granulocyte-colony stimulating factor (G-CSF) in macrophages and its underlying mechanism. The study arose from an observation that rapamycin inhibited the LPS-induced increase in octamer-binding factor-2 (Oct-2) protein levels through a mammalian target of rapamycin (mTOR)-dependent pathway in mouse RAW264.7 macrophages. As both iNOS and G-CSF are potential Oct-2 target genes, we tested the effect of rapamycin on their expression and found that it reduced the LPS-induced increase in iNOS and ...
https://tmu.pure.elsevier.com/zh/publications/rapamycin-inhibits-lipopolysaccharide-induction-of-granulocyte-co
Characteristics of nitric oxide synthase type I of rat cerebellar astrocytes, Glia | 10.1002/(SICI)1098-1136(199611)18:3|224:...Characteristics of nitric oxide synthase type I of rat cerebellar astrocytes, Glia | 10.1002/(SICI)1098-1136(199611)18:3|224:...
Read Characteristics of nitric oxide synthase type I of rat cerebellar astrocytes, Glia on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.deepdyve.com/lp/wiley/characteristics-of-nitric-oxide-synthase-type-i-of-rat-cerebellar-Up0znarAhb?impressionId=5efe0fea114b8&i_medium=docview&i_campaign=references&i_source=references
Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and...Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and...
TY - JOUR. T1 - Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and calmodulin binding. AU - Panda, Satya Prakash. AU - Polusani, Srikanth R.. AU - Kellogg, Dean L.. AU - Venkatakrishnan, Priya. AU - Roman, Madeline G.. AU - Demeler, Borries. AU - Masters, Bettie Sue S.. AU - Roman, Linda J.. N1 - Funding Information: The authors wish to thank Dr. Jung-Ja Kim, Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI-53226 for her critical reading of the manuscript and suggestions. Supported by NIH GM052419 to BSSM and LJR. BSSM is the Robert A. Welch Distinguished Professor in Chemistry (AQ-0012). The development of the UltraScan software is supported by the National Institutes of Health through grant RR022200 (to BD). Supercomputer time allocations were provided through National Science Foundation grant TG-MCB070038 (to BD). We acknowledge the support of the San Antonio Cancer Institute grant P30 CA054174 ...
https://scholars.uthscsa.edu/en/publications/intra-and-inter-molecular-effects-of-a-conserved-arginine-residue
Autoregulation of Inducible Nitric Oxide Synthase Expression by RNA Interference Provides Neuroprotection in Neonatal RatsAutoregulation of Inducible Nitric Oxide Synthase Expression by RNA Interference Provides Neuroprotection in Neonatal Rats
1. Agrawal N, Dasaradhi PV, Mohmmed A, Malhotra P, Bhatnagar RK, Mukherjee SK. RNA interference: biology, mechanism, and applications. Microbiol Mol Biol Rev. 2003;67:657-85 2. Xia XG, Zhou H, Xu Z. Promises and challenges in developing RNAi as a research tool and therapy for neurodegenerative diseases. Neurodegener Dis. 2005;2:220-31 3. Grimm D, Streetz KL, Jopling CL, Storm TA, Pandey K, Davis CR, Marion P, Salazar F, Kay MA. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature. 2006;441:537-41 4. Xia XG, Zhou H, Xu Z. Multiple shRNAs expressed by an inducible pol II promoter can knock down the expression of multiple target genes. Biotechniques. 2006;41:64-8 5. Lipton P. Ischemic cell death in brain neurons. Physiol Rev. 1999;79:1431-568 6. Zhao X, Ross ME, Iadecola C. L-Arginine increases ischemic injury in wild-type mice but not in iNOS-deficient mice. Brain Res. 2003;966:308-11 7. Garcia-Bonilla L, Moore JM, Racchumi G, Zhou P, Butler JM, Iadecola ...
https://www.thno.org/v05p0504.htm
Adjuvant Immunotherapy Is Dependent on Inducible Nitric Oxide Synthase | Journal of Experimental Medicine | Rockefeller...Adjuvant Immunotherapy Is Dependent on Inducible Nitric Oxide Synthase | Journal of Experimental Medicine | Rockefeller...
These studies support the hypothesis that the protective effects of CFA preimmunization require functional NOS2. CFA-preimmunized NOS2 knockout mice fail to be protected from the development of EAE. Wild-type mice protected by CFA demonstrate several alterations in their immune response to MOG that may be relevant to the mechanism of protection. The augmentation of anti-MOG IgG1 titers is likely an epiphenomenon rather than responsible for disease protection, as antibodies are not major effector mechanisms of disease in the MOG peptide model of EAE 26. It is interesting that NOD mice treated with CFA demonstrate an augmented IgG1 response to GAD67, consistent with our observation 27. The NO-dependent inhibition of IL-6 production with CFA treatment is highly significant. IL-6-deficient mice are entirely resistant to MOG-induced EAE 28,29,30. Furthermore, the mice that have been genetically modified to overexpress IL-6 in the CNS develop EAE spontaneously 31. The mechanism by which NO inhibits ...
https://rupress.org/jem/article/193/11/1261/25836/Adjuvant-Immunotherapy-Is-Dependent-on-Inducible
Adjuvant Immunotherapy Is Dependent on Inducible Nitric Oxide Synthase | JEMAdjuvant Immunotherapy Is Dependent on Inducible Nitric Oxide Synthase | JEM
Exposure to CFA can impair the subsequent expression of autoimmune disease in small rodents. This observation, also referred to as adjuvant immunotherapy, was first described over 40 years ago and found to be dependent on the presence of Mycobacterium tuberculosis within the adjuvant (1). This immunoprotective effect of CFA has been subsequently demonstrated in multiple autoimmune disease models, both spontaneous and induced, and in multiple species, including rats (2)(3)(4)(5), mice (6), and guinea pigs (1)(7)(8). In each case, preimmunization with CFA alone 21-40 d before attempted disease induction by immunization resulted in a decreased incidence and severity of disease (1)(2)(3)(7)(8).. Much of our current understanding of the CFA effect is derived from rodent models of spontaneous autoimmune diabetes mellitus. A single injection of CFA into nonobese diabetic (NOD) mice between the ages of 4 and 12 wk prevents the development of clinical diabetes indefinitely and extends NOD life span ...
http://jem.rupress.org/content/193/11/1261
Exogenous and endogenous nitric oxide but not iNOS inhibition improves function and survival of ischemically injured livers<...
TY - JOUR. T1 - Exogenous and endogenous nitric oxide but not iNOS inhibition improves function and survival of ischemically injured livers. AU - Rivera-Chavez, F. A.. AU - Toledo-Pereyra, L. H.. AU - Dean, R. E.. AU - Crouch, L.. AU - Ward, P. A.. PY - 2001/11/20. Y1 - 2001/11/20. N2 - The role of nitric oxide (NO) in liver ischemia/reperfusion (I/R) injury remains controversial and few works have shed more information regarding the effect of exogenous (EX) and/or endogenous NO (EN) under conditions of I/R of the liver. We investigated the role of exogenous and endogenous NO and inducible nitric oxide synthase (iNOS) inhibition in liver function, neutrophil infiltration, and animal survival after liver I/R. Sprague-Dawley rats were subjected to total hepatic ischemia for 90 min using an extracorporeal porto-systemic shunt. The animals were divided into five groups, including the sham porto-systemic shunt with no ischemia, the control ischemic group, the L-arginine-treated group, the sodium ...
https://nebraska.pure.elsevier.com/en/publications/exogenous-and-endogenous-nitric-oxide-but-not-inos-inhibition-imp
Regulation of cytokine-induced iNOS expression by a hairpin oligonucleotide in murine cerebral endothelial cells. - PubMed -...Regulation of cytokine-induced iNOS expression by a hairpin oligonucleotide in murine cerebral endothelial cells. - PubMed -...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/9199204?dopt=Abstract
Periadventitial Inducible Nitric Oxide Synthase Expression and Intimal Thickening | Arteriosclerosis, Thrombosis, and Vascular...Periadventitial Inducible Nitric Oxide Synthase Expression and Intimal Thickening | Arteriosclerosis, Thrombosis, and Vascular...
Annoying problems with the specificity of iNOS immunostains have recently been reported.22 The main conclusion was that it is essential to include appropriate controls for the species studied, and if possible, to confirm the immunostaining by another technique such as RT-PCR. Hence, we carefully controlled our iNOS immunostains by using appropriate negative (naïve rabbit carotid artery and omission of the primary antibody) and positive controls as well as RT-PCR.. Previously, the presence of iNOS in the intimal thickening induced by a periarterial collar in the rabbit carotid artery had been reported.13 In that study, a rabbit polyclonal iNOS antiserum (primary antibody) and a donkey anti-rabbit IgG-peroxidase (secondary antibody) were used. However, we found that omitting the primary antibody yielded an identical result. Inthe absence of the primary antibody, the immunoreactivity in the intima can be explained by reaction of the secondary antibody with IgG that has infiltrated into the intima ...
http://atvb.ahajournals.org/content/20/8/1896
Cholecystokinin Inhibits Inducible Nitric Oxide Synthase Expression by Lipopolysaccharide-Stimulated Peritoneal MacrophagesCholecystokinin Inhibits Inducible Nitric Oxide Synthase Expression by Lipopolysaccharide-Stimulated Peritoneal Macrophages
Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.
https://www.hindawi.com/journals/mi/2014/896029/cta/
Microbiology Society Journals | Mice lacking inducible nitric-oxide synthase are more susceptible to herpes simplex virus...Microbiology Society Journals | Mice lacking inducible nitric-oxide synthase are more susceptible to herpes simplex virus...
Mice deficient in the inducible nitric-oxide synthase (iNOS), constructed by gene-targeting, were significantly more susceptible to herpes simplex virus (HSV)-1 infection, displayed a delayed clearance of virus from the dorsal root ganglia (DRG) and exhibited an increase in the frequency of virus reactivation in DRG compared with similarly infected heterozygous mice. The infected iNOS-deficient mice developed enhanced Th1-type immune responses and their spleen cells produced higher concentrations of IL-12 than similarly infected heterozygous mice. This finding suggests that iNOS plays an important role in resistance against HSV-1 infection. Furthermore, nitric oxide (NO) may block the development of Th1 cells via inhibition of IL-12 synthesis and thereby play a role in immune regulation.
http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-79-4-825
Nitric Oxide Synthase Type I | The Chopra LibraryNitric Oxide Synthase Type I | The Chopra Library
BACKGROUND: Duchenne muscular dystrophy (DMD) is the most common, lethal disease of childhood. One of 3500 new-born males suffers from this universally-lethal disease. Other than the use of corticosteroids, little is available to affect the relentless progress of the disease, leading many families to use dietary supplements in hopes of reducing the progression or severity of muscle wasting. Arginine is commonly used as a dietary supplement and its use has been reported to have beneficial effects following short-term administration to mdx mice, a genetic model of DMD ...
http://isharonline.org/tags/nitric-oxide-synthase-type-i
1400W, iNOS inhibitor (CAS 214358-33-5) (ab120165) | Abcam1400W, iNOS inhibitor (CAS 214358-33-5) (ab120165) | Abcam
MW 250.17, Purity | 97%. Selective iNOS inhibitor, 5000-fold selective over eNOS (Kd values are ≤7 nM, 2 μM and 50 μM at human iNOS, nNOS and eNOS, respectively).
https://www.abcam.com/1400w-inos-inhibitor-ab120165.html
Synthases/Synthetases - EnzymesSynthases/Synthetases - Enzymes
AR-C 102222 is an inducible nitric oxide synthase (iNOS) inhibitor; selective for iNOS over eNOS (IC50 values are 0.037 and ,100 μM for iNOS and eNOS respectively) and exhibits antinociceptive and anti-inflammatory activity in rodent pain models. Learn More ...
https://www.emmx.com/synthases-synthetases.html
Prevention of nitric oxide synthase induction in vascular smooth muscle cells by microtubule depolymerizing agents<...Prevention of nitric oxide synthase induction in vascular smooth muscle cells by microtubule depolymerizing agents<...
TY - JOUR. T1 - Prevention of nitric oxide synthase induction in vascular smooth muscle cells by microtubule depolymerizing agents. AU - Marczin, Nándor. AU - Papapetropoulos, Andreas. AU - Jilling, Tamás. AU - Catravas, John D.. PY - 1993/1/1. Y1 - 1993/1/1. N2 - We investigated the role of microtubules in the induction of nitric oxide synthase in cultured vascular smooth muscle cells. We found that like interleukin‐1α, lipopolysaccharide elicited a time and concentration‐dependent accumulation of cyclic GMP via induction of nitric oxide synthase. Nocodazole and colchicine, two chemically distinct microtubule depolymerizing agents, completely prevented lipopolysaccharide‐ and interleukin‐induced (and nitric oxide‐mediated) cyclic GMP generation. In contrast to lipopolysaccharide and interleukin‐1α, cyclic GMP accumulation in response to sodium nitroprusside, an exogenous nitrovasodilator, was not altered by either nocodazole or colchicine. Our findings demonstrate that ...
https://researchexperts.utmb.edu/en/publications/prevention-of-nitric-oxide-synthase-induction-in-vascular-smooth-
IJMS | Free Full-Text | Pu-erh Tea Reduces Nitric Oxide Levels in Rats by Inhibiting Inducible Nitric Oxide Synthase Expression...IJMS | Free Full-Text | Pu-erh Tea Reduces Nitric Oxide Levels in Rats by Inhibiting Inducible Nitric Oxide Synthase Expression...
Pu-erh tea undergoes a unique fermentation process and contains theabrownins, polysaccharides and caffeine; although it is unclear about which component is associated with the down regulation of nitric oxide levels or how this process is mediated. To address this question we examined the effects of pu-erh tea on nitric oxide synthase (NOS) genes. Cohorts of rats were separately given four-week treatments of water as control, pu-erh tea, or the tea components: theabrownins, caffeine or polysaccharides. Five experimental groups were injected with lipopolysaccharides (LPS) to induce nitric oxide (NO) production, while the corresponding five control groups were injected with saline as a negative control. The serum and liver NO concentrations were examined and the NOS expression of both mRNA and protein was measured in liver. The results showed that the rats which were fed pu-erh tea or polysaccharides had lower levels of NO which corresponded with the down-regulation of inducible nitric oxide synthase (iNOS
http://www.mdpi.com/1422-0067/13/6/7174
The Effects of Inducible Nitric Oxide Synthase Inhibitor L-N6-(1-Iminoethyl) Lysine in Gentamicin-Induced Acute Tubular...The Effects of Inducible Nitric Oxide Synthase Inhibitor L-N6-(1-Iminoethyl) Lysine in Gentamicin-Induced Acute Tubular...
The aim of this study was to investigate the role of inducible nitric oxide synthase (iNOS) in gentamicin-induced acute tubular necrosis in rats using the iNOS inhibitor L-N6-(1-iminoethyl) lysine (L-NIL). Wistar rats, both sexes (n=18), were equally divided into three groups. Gentamicin group received intraperitoneally (i.p.) gentamicin in 0,9 % NaCl at a dose of 80 mg/kg/day for five consecutive days. L-NIL+gentamicin group received L-NIL at a dose of 3mg/kg i.p. 36, 24 and 12 h before first dose of gentamicin. Control group received 0,9 % NaCl i.p. for five consecutive days at the equal volume as gentamicin group. Griess reaction was used for determination plasma level of NO. Semiquantitative histological analysis was used for the evaluation of kidney damage level. The plasma NO level and the level of kidney damage were statistically higher in gentamicin group in comparison to the control group (p=0,046). Application of L-NIL prior to gentamicin led to certain decrease in the plasma level of ...
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3025
The Oct DNA motif participates in the alcohol inhibition of the inducible nitric oxide synthase gene promoter in rat C6 glioma...The Oct DNA motif participates in the alcohol inhibition of the inducible nitric oxide synthase gene promoter in rat C6 glioma...
TY - JOUR. T1 - The Oct DNA motif participates in the alcohol inhibition of the inducible nitric oxide synthase gene promoter in rat C6 glioma cells. AU - Sanchez, Alma C.. AU - Davis, Randall L.. AU - Syapin, Peter J.. PY - 2007/11/7. Y1 - 2007/11/7. N2 - Induction of nitric oxide synthase-2 (iNOS) by cytokines and bacterial products is associated with protein binding at the proximal promoter and in an upstream enhancer region of the Nos2 gene. To clarify how ethanol suppresses rat iNOS activity, we constructed several deletion mutants of the Nos2 promoter fused to the luciferase gene and transfected the constructs into C6 glial cells. Acute ethanol exposure of stably transfected cells for 24 h inhibits induced activity of Nos2 promoter constructs containing deletions in the 5′ flanking region, including a 94 bp promoter that lacks any known NF-κB site but which carries a C/EBPβ and overlapping γ-IRE, GAS and Oct motifs. Ethanol failed to inhibit the endogenous activity of a smaller, 78 bp ...
https://scholars.okstate.edu/en/publications/the-oct-dna-motif-participates-in-the-alcohol-inhibition-of-the-i
Chamomile: An anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activityChamomile: An anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity
Chamomile has long been used in traditional medicine for the treatment of inflammation-related disorders. In this study we investigated the inhibitory effects of chamomile on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression, and explored its potential anti-inflammatory mechanisms using RAW 264.7 macrophages. Chamomile treatment inhibited LPS-induced NO production and significantly blocked IL-1β, IL-6 and TNFα-induced NO levels in RAW 264.7 macrophages. Chamomile caused reduction in LPS-induced iNOS mRNA and protein expression. In RAW 264.7 macrophages, LPS-induced DNA binding activity of RelA/p65 was significantly inhibited by chamomile, an effect that was mediated through the inhibition of IKKβ, the upstream kinase regulating NF-κB/Rel activity, and degradation of inhibitory factor-κB. These results demonstrate that chamomile inhibits NO production and iNOS gene expression by inhibiting RelA/p65 activation and supports the utilization of chamomile as an ...
https://www.spandidos-publications.com/ijmm/26/6/935
Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback...
TY - JOUR. T1 - Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition. AU - Galijasevic, Semira. AU - Saed, Ghassan M.. AU - Diamond, Michael P.. AU - Abu-Soud, Husam M.. PY - 2003/12/9. Y1 - 2003/12/9. N2 - Kinetic and structure analysis of inducible nitric oxide synthase (iNOS) revealed that, in addition to the increase of iNOS expression in inflamed areas, the major pathway causing overproduction of NO is destabilization of the iNOS-nitrosyl complex(es) that form during steady-state catalysis. Formation of such a complex allows iNOS to operate at only a fraction (20-30%) of its maximum activity. Thus, bioavailability of NO scavengers at sites of inflammation may play an essential role in up-regulation of the catalytic activity of iNOS, by preventing the catalytic activity inhibition that is attributed to nitrosyl complex formation. Myeloperoxidase (MPO), a major NO scavenger, is a pivotal enzyme involved in ...
https://augusta.pure.elsevier.com/en/publications/myeloperoxidase-up-regulates-the-catalytic-activity-of-inducible-
Lirias: Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitusLirias: Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitus
PURPOSE: Inducible nitric oxide synthase has been implicated in the pathogenesis of cerebral ischemic damage, in the angiogenic process and in diabetic vascular damage. This study was undertaken to determine whether inducible nitric oxide synthase is present in the retinas from human subjects with diabetes mellitus. METHODS: This was an experimental immunohistochemical prospective study. Ten postmortem eyes from five subjects with diabetes mellitus, 10 eyes from five subjects without diabetes and without known ocular disease, and two eyes from one subject with unilateral ocular ischemic syndrome secondary to severe carotid artery obstruction were examined. We used immunohistochemical techniques and antibodies directed against inducible nitric oxide synthase, glial fibrillary acidic protein, and vimentin. The main outcome measure was immunoreactivity for these antibodies. RESULTS: Immunoreactivity for inducible nitric oxide synthase was not observed in retinas from all subjects without diabetes ...
https://lirias.kuleuven.be/handle/123456789/28018
Interferon-γ-Induced Nitric Oxide Synthase-2 Contributes to Blood/Brain Barrier Dysfunction and Acute Mortality in Experimental...Interferon-γ-Induced Nitric Oxide Synthase-2 Contributes to Blood/Brain Barrier Dysfunction and Acute Mortality in Experimental...
J Interferon Cytokine Res. 2015 Sep 29. [Epub ahead of print]. Interferon-γ-Induced Nitric Oxide Synthase-2 Contributes to Blood/Brain Barrier Dysfunction and Acute Mortality in Experimental Streptococcus pneumoniaeMeningitis.. Yau B1, Mitchell AJ1,2, Too LK1, Ball HJ1, Hunt NH1.. Author information. Abstract. The proinflammatory cytokine interferon-gamma (IFNγ) recently was shown to play a crucial role in experimental pneumococcal meningitis (PM) pathogenesis, and we aimed in this study to investigate IFNγ-driven nitric oxide synthase-2 (NOS2)-mediated pathogenesis of murine PM. We demonstrate that costimulation of toll-like receptors and IFNγ receptors was synergistic for NOS2 expression in cultured murine microglia. Using an experimental PM model, wild-type mice treated with anti-IFNγ antibody, as well as IFNγ and NOS2 gene knockout (GKO) mice, were inoculated intracerebroventricularly with 103 colony-forming units of Streptococcus pneumoniae (WU2 strain). Mice were monitored daily ...
http://www.vanopijnenlab.com/news/2015/10/2/interferon-induced-nitric-oxide-synthase-2-contributes-to-bloodbrain-barrier-dysfunction-and-acute-mortality-in-experimental-streptococcus-pneumoniaemeningitis
The role of inducible nitric oxide synthase in macrophage activation following acute lung injuryThe role of inducible nitric oxide synthase in macrophage activation following acute lung injury
DescriptionMacrophage origin and activity is complex in response to acute lung injury. Inducible nitric oxide synthase (iNOS) has a divergent role in the stages following intratracheal bleomycin mediated lung injury (ITB). We hypothesize iNOS is necessary for macrophage activation during the inflammatory and resolution phases that follow ITB. Further, recruited macrophages classically activate during inflammation and resident macrophages alternatively activate during resolution. To test these hypotheses, iNOS was manipulated via scavenge of products, systemic selective iNOS inhibition and chimeric mice in which particular populations were NOS2-/-. C57/BL6 mice were intratracheally instilled with bleomycin and samples collected 8 and 15 days following instillation. This work identified oxidants to promote inflammation during the early stages following ITB. Systemic iNOS inhibition reduced classical activation of recruited macrophages during inflammation and alternative activation of recruited ...
https://rucore.libraries.rutgers.edu/rutgers-lib/51297/
High inducible nitric oxide synthase in prostate tumor epithelium is associated with lethal prostate cancerHigh inducible nitric oxide synthase in prostate tumor epithelium is associated with lethal prostate cancer
OBJECTIVE: The aim of this study was to investigate the role of inducible nitric oxide synthase (iNOS) in lethal prostate cancer (PCa) by studying the iNOS immunoreactivity in tumor tissue from men diagnosed with localized PCa.. MATERIALS AND METHODS: This study is nested within a cohort of men diagnosed with incidental PCa undergoing transurethral resection of the prostate (the Swedish Watchful Waiting Cohort). To investigate molecular determinants of lethal PCa, men who died from PCa (n = 132) were selected as cases; controls (n = 168) comprised men with PCa who survived for at least 10 years without dying from PCa during follow-up. The immunoreactivity of iNOS in prostate tumor epithelial cells and in cells of the surrounding stroma was scored as low/negative, moderate or high. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for lethal PCa according to iNOS category.. RESULTS: There was no association between iNOS immunoreactivity in stroma ...
http://oru.diva-portal.org/smash/record.jsf?pid=diva2%3A1173599&c=21&searchType=RESEARCH&language=en&query=&af=%5B%5D&aq=%5B%5B%7B%22personId%22%3A%22authority-person%3A37426%22%7D%5D%5D&aq2=%5B%5B%5D%5D&aqe=%5B%5D&noOfRows=50&sortOrder=author_sort_asc&sortOrder2=title_sort_asc&onlyFullText=false&sf=all
IJMS | Free Full-Text | Elevation of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in the Mouse Brain after...IJMS | Free Full-Text | Elevation of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in the Mouse Brain after...
The present study was performed to investigate the effects of chronic administration of nonylphenol (NP) on the expression of inflammation-related genes in the brains of mice. NP was given orally by gavages at 0, 50, 100, and 200 mg/kg/d. The expression of inflammatory enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), was evaluated by immunohistochemistry and immunoblotting assays. The nitric oxide (NO) level and nitric oxide synthase (NOS) activity were also measured by biochemical analyses. The results showed that NP at a high dose (200 mg/kg/d) significantly increased the expression of iNOS and COX-2 in both the hippocampus and cortex. In parallel with the increase in iNOS expression, the NO level was significantly greater at the dose of 200 mg/kg/d, compared to the control. The activity of NOS was also increased in the brain of mice at the dose of 100 and 200 mg/kg/d. These findings demonstrate that NP may have the potential to induce the chronic inflammation or cause
http://www.mdpi.com/1422-0067/9/10/1977/notes
Effect of 17-? Estradiol on the Expression of Inducible Nitric oxide Synthase in Parent and Tamoxifen Resistant T47D Breast...Effect of 17-? Estradiol on the Expression of Inducible Nitric oxide Synthase in Parent and Tamoxifen Resistant T47D Breast...
Indirect evidence suggests that estrogen is involved in the etiology of breast cancer. Estrogen is also thought to modulate nitric oxide (NO) in human breast tumor tissue via regulation of inducible nitric oxide synthase (iNOS). Objectives of this study were to determine whether estradiol (E2) affects iNOS expression level in breast cancer cells and to study the effect of various concentrations of E2 on cell proliferation. Immunocytochemical technique was employed to assess iNOS expression level. Proliferation of parent and 10-6 M tamoxifen resistant cells (T47D/TAMR-6) were assessed by MTT assay in the presence of E2. Addition of E2 (10-12 to 10-8 M) increases the expression of iNOS in parent cells, but not T47D/TAMR-6, Further increase in concentrations of E2 (10-8 to 10-4 M) again decreases the expression of iNOS in parent cells, but increase that of the T47D/TAMR-6 cells. Expression of iNOS in parent cells in a medium containing 1% serum (low serum) is less than the cells grown in a medium
http://ijpr.sbmu.ac.ir/article_800.html
Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric oxide synthase and gastric mucosal...Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric oxide synthase and gastric mucosal...
Infection with Helicobacter pylori is recognized as a primary factor in the etiology of gastric disease and its early pathogenic effects are manifested by up-regulation in proinflammatory cytokine release, enhancement in nitric oxide generation, and amplification of apoptotic events. We applied the animal model of H. pylori -induced gastritis to study the effect of a specific inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), SB 203580, on the mucosal apoptotic processes, and the expression of inducible nitric oxide synthase (NOS-2) activity and soluble tumor necrosis factor-α (TNF-α). Groups of rats were pretreated intragastrically with SB 203580 (5, 10, and 20 mg/kg) or vehicle, followed 60 min later by intragastric application of H. pylori lipopolysaccharide at 50 μg/animal, and after 2 and 4 additional days on the twice daily regimen of SB 203580 or vehicle, the animals were killed and their gastric mucosal tissue subjected to histologic and biochemical assessment. In the absence of SB
http://booksandjournals.brillonline.com/content/journals/10.1163/156856000750264438
Expression of Inducible Nitric Oxide Synthase and Nitrotyrosin...Expression of Inducible Nitric Oxide Synthase and Nitrotyrosin...
Expression of Inducible Nitric Oxide Synthase and Nitrotyrosine in Multiple Sclerosis Lesions: Nitric oxide generated by the inducible form of nitric oxide synt
https://www.mysciencework.com/publication/show/expression-of-inducible-nitric-oxide-synthase-and-nitrotyrosine-in-multiple-sclerosis-lesions
Triggering of Peritoneal Macrophages with IFN-α/β Attenuates the Expression of Inducible Nitric Oxide Synthase Through a...Triggering of Peritoneal Macrophages with IFN-α/β Attenuates the Expression of Inducible Nitric Oxide Synthase Through a...
In this work, we have analyzed the effect of IFN-α/β on the expression of iNOS in macrophages activated with suboptimal concentrations of LPS and IFN-γ, a model in which cooperation between these two factors is well known (2, 3, 4, 5, 6). However, the data regarding the effect of type I IFNs on iNOS transcription are rather controversial: IFN-α/β is induced and secreted by macrophages after triggering with IFN-γ, LPS, or combinations of both, and the kinetics of the process are well known (15, 27, 28). Challenge of the murine macrophage cell line J774 with LPS induces the synthesis of IFN-α/β after 3 h of treatment (27), a time at which we have observed that the addition of IFN-α/β has minimal effects on the expression of iNOS. Moreover, if the culture medium is depleted of IFN-α/β with a neutralizing Ab, the synthesis of NO markedly decreases, indicating that type I IFNs might participate in an autocrine loop intended to maintain iNOS levels in LPS-activated J774 cells. However, ...
https://www.jimmunol.org/content/160/6/2889
AID 735304 - Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess...AID 735304 - Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess...
BioAssay record AID 735304 submitted by ChEMBL: Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reaction analysis.
https://pubchem.ncbi.nlm.nih.gov/bioassay/735304
Population dynamics of inducible nitric oxide synthase production by LPS- and LPS/IFNgamma-stimulated mouse macrophages<...
TY - JOUR. T1 - Population dynamics of inducible nitric oxide synthase production by LPS- and LPS/IFNgamma-stimulated mouse macrophages. AU - Pace, J. L.. AU - Lowenstein, C. J.. AU - Phillips, T. A.. AU - Chen, L. C.. AU - Morrison, D. C.. AU - Hunt, J. S.. AU - Russell, S. W.. PY - 1994. Y1 - 1994. UR - http://www.scopus.com/inward/record.url?scp=0028189509&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0028189509&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0028189509. VL - 1. SP - 227. EP - 233. JO - Innate Immunity. JF - Innate Immunity. SN - 1753-4259. IS - 4. ER - ...
https://jhu.pure.elsevier.com/en/publications/population-dynamics-of-inducible-nitric-oxide-synthase-production-3
eCite - Inducible nitric oxide synthase in response to bacterial challenge in nasal tissues of wild type, CX3CR1+/GFP and CX3...eCite - Inducible nitric oxide synthase in response to bacterial challenge in nasal tissues of wild type, CX3CR1+/GFP and CX3...
Inducible nitric oxide synthase in response to bacterial challenge in nasal tissues of wild type, CX3CR1|sup|+/GFP|/sup| and CX3 CR1|sup|GFP/GFP|/sup| mice
http://ecite.utas.edu.au/92641
Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS...Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS...
Increased expression of inducible nitric oxide synthase (iNOS) resulting in nitric oxide elevation represents an important component of inflammatory responses. We assess the effects of methylprednisolone (MPL) on these processes during endotoxin-induced acute inflammation and provide a mechanism-based model to
https://www.certara.com/citations/pharmacokineticpharmacodynamic-modeling-of-methylprednisolone-effects-on-inos-mrna-expression-and-nitric-oxide-during-lps-induced-inflammation-in-rats/
Cardioprotection Afforded by Inducible Nitric Oxide Synthase Gene Therapy Is Mediated by Cyclooxygenase-2 via a Nuclear Factor...Cardioprotection Afforded by Inducible Nitric Oxide Synthase Gene Therapy Is Mediated by Cyclooxygenase-2 via a Nuclear Factor...
NF-κB is a ubiquitous dimeric transcription factor that exists in the cytosol complexed to an inhibitory κB (IκB) monomer. NF-κB complexes consist most commonly of p50/p65 dimers.26,27 Various stimuli activate NF-κB, leading to its translocation to the nucleus, where it binds to specific DNA binding sites, called κB, present within the promoter region of various genes including COX-2.27 Activation of NF-κB is controlled by site-specific phosphorylation and ubiquitination of IκB proteins.26 Among the known IκB proteins, IκBα and IκBβ have been studied most extensively and are thought to be the key regulators of NF-κB nuclear translocation. Phosphorylation of serine residues at positions 32 and 36 is critical for the ubiquitination and degradation of IκBα.16,28,29. Pharmacological studies have implicated NF-κB as a necessary transcription factor in the development of late PC.1,3,12,30 Unequivocal assessment of the functional contribution of NF-κB to this process, however, has ...
http://circ.ahajournals.org/content/116/14/1577
The inducible nitric oxide synthase gene, Nos2, maps to mouse chromos by I C. Gerling, A E. Karlsen et al.The inducible nitric oxide synthase gene, Nos2, maps to mouse chromos by I C. Gerling, A E. Karlsen et al.
Animal, Base-Sequence, Chromosome-Mapping, Crosses-Genetic, Enzyme-Induction, Genes-Structural, Human, Hybridization, Mice: ge, Mice-Inbred-C57BL, Mice-Inbred-NOD: ge, Molecular-Sequence-Data, Muridae: ge, Rats, Rats-Wistar, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S. ...
https://mouseion.jax.org/stfb1990_1999/549/
Cytokines and innate immunity of fish<...Cytokines and innate immunity of fish<...
TY - JOUR. T1 - Cytokines and innate immunity of fish. AU - Secombes, C J. AU - Wang, T. AU - Hong, S. AU - Peddie, S. AU - Crampe, M. AU - Laing, K J. AU - Cunningham, C. AU - Zou, J. AU - Wang, Tiehui. PY - 2001/10. Y1 - 2001/10. KW - interleukin-1 beta. KW - tumor necrosis factor alpha. KW - chemokines. KW - cyclooxygenase. KW - nitric oxide synthase. KW - trout oncorhynchus-mykiss. KW - nitric-oxide synthase. KW - molecular-cloning. KW - chemokine receptors. KW - Japanese flounder. KW - expression. KW - interleukin-1-beta. KW - gene. KW - homolog. KW - organization. KW - Animals, Chemokines, Cytokines, Fishes, Humans, Interleukin-1, Nitric Oxide Synthase, Nitric Oxide Synthase Type II, Phylogeny, Prostaglandin-Endoperoxide Synthases, Tumor Necrosis Factor-alpha. U2 - 10.1016/S0145-305X(01)00032-5. DO - 10.1016/S0145-305X(01)00032-5. M3 - Article. C2 - 11602192. VL - 25. SP - 713. EP - 723. JO - Developmental and Comparative Immunology. JF - Developmental and Comparative Immunology. SN - ...
https://abdn.pure.elsevier.com/en/publications/cytokines-and-innate-immunity-of-fish
Plus itPlus it
Here we demonstrated that aging increased iNOS expression, leading to insulin resistance in the skeletal muscle through the S-nitrosation mechanism. Genetic, pharmacological, and physiological iNOS inhibition reduced IRβ, IRS-1, and Akt S-nitrosation and increased insulin signaling in old mice. Our results reinforce the idea that iNOS plays a crucial role in inducing insulin resistance, as previously shown in different animal models such as diet-, lipopolysaccharide-, and lipid-induced skeletal muscle insulin resistance (3,13,15,16).. In contrast to our data, Cha et al. (17) reported that iNOS deficiency does not prevent age-associated insulin resistance. In contrast to the previous study, we did not observe an increase in TNF-α expression in the skeletal muscle of aged iNOS-null mice compared with the aged wild-type group; these data were confirmed by analyzing IKKβ phosphorylation. In accordance with our data, a previous study showed iNOS knockout mice were protected from insulin resistance ...
http://diabetes.diabetesjournals.org/content/62/2/466
Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation | Circulation ResearchTransdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation | Circulation Research
Rationale: We have previously shown that innate immunity is necessary for transdifferentiation of fibroblasts to endothelial cells. A major signaling molecule involved in innate immunity is inducible nitric oxide synthase (iNOS). Accordingly, we hypothesized that iNOS-generated nitric oxide (NO) might enhance transdifferentiation. Objective: To elucidate the role of NO in epigenetic plasticity during transdifferentiation. Methods and Results: We exposed the BJ fibroblasts to transdifferentiation formulation that included endothelial growth factors and innate immune activator polyinosinic:polycytidylic acid (PIC) to induce endothelial cells (iECs). Generation of iECs was associated with iNOS expression and NO elaboration. In absence of PIC, or in presence of antagonists of NFκB or iNOS activity, NO synthesis and iEC generation was reduced. Furthermore, genetic knockout (in MEFs) or siRNA knockdown (in BJ fibroblasts) of iNOS nearly abolished transdifferentiation, an effect which could be ...
http://circres.ahajournals.org/content/early/2016/09/13/CIRCRESAHA.116.308263
A novel role of interleukin-1-converting enzyme in cytokine-me...A novel role of interleukin-1-converting enzyme in cytokine-me...
A novel role of interleukin-1-converting enzyme in cytokine-mediated inducible nitric oxide synthase gene expression: Implications for neuroinflammatory disease
https://www.mysciencework.com/publication/show/novel-role-interleukin-1-converting-enzyme-cytokine-mediated-inducible-nitric-oxide-synthase-gene-expression-implicatio-b7664926
MEDICA
Neuroglia;Astrocytes;Microglia;Inflammation;AMP-Activated Protein Kinases;AICA ribonucleotide;NF-kappa B;Cytokines;Macrophages, Peritoneal;Cells, Cultured;Rats, Sprague-Dawley;Models, Animal;Nitric Oxide Synthase;Nitric Oxide Synthase Type ...
http://digital.library.musc.edu/cdm/search/searchterm/kinase/mode/all/order/title
MEDICA
Neuroglia;Astrocytes;Microglia;Inflammation;AMP-Activated Protein Kinases;AICA ribonucleotide;NF-kappa B;Cytokines;Macrophages, Peritoneal;Cells, Cultured;Rats, Sprague-Dawley;Models, Animal;Nitric Oxide Synthase;Nitric Oxide Synthase Type ...
http://digital.library.musc.edu/cdm/search/searchterm/interleukin-6
Modulation of In Vivo Cardiac Function by Myocyte-Specific Nitric Oxide Synthase-3 | Circulation ResearchModulation of In Vivo Cardiac Function by Myocyte-Specific Nitric Oxide Synthase-3 | Circulation Research
Thank you for your interest in spreading the word on Circulation Research.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
http://circres.ahajournals.org/content/early/2004/01/29/01.RES.0000119323.79644.20
Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive...
Essential hypertension is a proinflammatory, proconstrictor disease coinciding with endothelial dysfunction and inward vessel remodeling. Using the skin circulation, our aim was to determine whether inducible NO synthase (iNOS) upregulation attenuate
http://www.biomedsearch.com/nih/Upregulation-Inducible-Nitric-Oxide-Synthase/21931069.html
αβ T Cell Receptor-positive Cells and Interferon-γ, but not Inducible Nitric Oxide Synthase, Are Critical for Granuloma...αβ T Cell Receptor-positive Cells and Interferon-γ, but not Inducible Nitric Oxide Synthase, Are Critical for Granuloma...
M. avium TMC724 (originally obtained from the Trudeau Institute) was passaged in C57BL/6 mice and cultured in Middlebrook 7H9 (Difco) medium supplemented with oleic acid, albumin, dextrose, and catalase (Becton Dickinson) to a late logarithmic phase. Aliquots were frozen at -70°C until needed. An inoculum of bacteria was prepared by thawing several aliquots, washing them by centrifugation at 16,000 g for 15 min, and pooling the pellets in distilled water. Aerogenic infection was performed in a Glas-Col aerosol infection device (Glas-Col). Mice were exposed for 40 min to an aerosol generated by nebulizing ∼5.5 ml of a suspension containing 109 CFU/ml M. avium TMC724. Inoculum size (∼105 CFU/lung) was checked 24 h after infection by determining the bacterial load in the lungs of infected mice. Mice were scored as moribund and killed when weight loss was in excess of 30% compared with age-matched uninfected controls. Groups of 4-6 mice were anaesthetized and killed at indicated time points to ...
https://rupress.org/jem/article/194/12/1847/39413/%CE%B1%CE%B2-T-Cell-Receptorpositive-Cells-and-Interferon%CE%B3
Delayed preconditioning against infarction may involve inducible nitric oxide synthase - UCL DiscoveryDelayed preconditioning against infarction may involve inducible nitric oxide synthase - UCL Discovery
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
http://discovery.ucl.ac.uk/74966/
Dinauer, C.
Nitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents. Journal of Endocrinological Investigation. 2002 ...
http://vivo.med.cornell.edu/display/person855743
给患者设定饮食处方时必须做到:准确、快速、易懂、实用。传统的食物交换份法(将食物按照来源、性质分成几大类。同类食物在一定重量内所含 | 生物志
目的研究人工合成的植物雌激素-依普拉芬对去卵巢大鼠骨密度及生物力学的影响;同时与雌激素对照,探讨其骨保护效果及NO调控作用机制。方法60只6月龄SD雌性大鼠,随机分成6组:假手术组和手术切除大鼠双侧卵巢组,后者分为阴性对照组、依普拉芬低、中Selleck、高剂量组和雌激素对照组,分别给予基础饲料和不同剂量受试物,12周后进行骨密度、血清NO及NOS浓度测定;免疫组化方法检测股骨NOS表达。结果与假手术组相比,去卵巢大鼠阴性对照组股骨密度、生物力学指标和血清NO、eNOS浓度以及股骨eNOS表达明显降低,血清iNOS浓度以及股骨iNOS表达增加,依普拉芬组骨密度、生物力学指标血清NO、eNOS浓度以及股骨eNOS表达均高于阴性对照组,与假手术组差异无显著意义。同时低于雌激素组。. ...
https://thrombin-signal.com/?p=7092
Fenbutatin Oxide CAS 13356-08-6 Bendex | MOSINTERFenbutatin Oxide CAS 13356-08-6 Bendex | MOSINTER
Good quality Fenbutatin Oxide CAS 13356-08-6 Bendex, find complete details about Fenbutatin Oxide CAS 13356-08-6 Bendex from MOSINTER.
https://www.mosinterchem.com/Fenbutatin-Oxide-CAS-13356-08-6-Bendex-pd49915885.html
FABORY Tap Bolt,7/16-14x2,Gr 8,Black Oxide,PK25 - 21C394|U04110.043.0200 - GraingerFABORY Tap Bolt,7/16-14x2,Gr 8,Black Oxide,PK25 - 21C394|U04110.043.0200 - Grainger
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tetraarsenic oxide | Semantic Scholartetraarsenic oxide | Semantic Scholar
In the present study, we investigated the effect of tetraarsenic oxide (As4O6, 2,4,6,8,9,10-Hexaoxa-1,3,5,7-tetraarsatricyclo[3.3… Expand ...
https://www.semanticscholar.org/topic/tetraarsenic-oxide/688157
ഫലകം:Oxides - വിക്കിപീഡിയഫലകം:Oxides - വിക്കിപീഡിയ
വിവരങ്ങൾ ക്രിയേറ്റീവ് കോമൺസ് ആട്രിബ്യൂഷൻ-ഷെയർഎലൈക്ക് അനുമതിപത്ര പ്രകാരം ലഭ്യമാണ്; മേൽ നിബന്ധനകൾ ഉണ്ടായേക്കാം. കൂടുതൽ വിവരങ്ങൾക്ക് ഉപയോഗനിബന്ധനകൾ കാണുക ...
https://ml.wikipedia.org/wiki/%E0%B4%AB%E0%B4%B2%E0%B4%95%E0%B4%82:Oxides
Nitric oxide synthase 2 (inducible)Nitric oxide synthase 2 (inducible)
"Role of Nitric Oxide Synthase Type 2 in Acute Infection with Murine Cytomegalovirus". The Journal of Immunology. 166 (5): 3533- ... Alternative splicing of this gene results in two transcript variants encoding different isoforms. Nitric oxide synthase is ... Nitric oxide synthase, inducible is an enzyme which is encoded by the NOS2 gene in humans and mice. Three related pseudogenes ... "Entrez Gene: NOS2A nitric oxide synthase 2A (inducible, hepatocytes)". Nathan, C. (2006-06-30). "Role of iNOS in Human Host ...
https://en.wikipedia.org/wiki/Nitric_oxide_synthase_2_(inducible)
Anne La FlammeAnne La Flamme
"Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology ... La Flamme, Anne C. (1997). Trypanosoma cruzi-infected macrophages are defective in class II antigen presentation. Thesis (Ph. D ... Trypanosoma cruzi-infected macrophages are defective in class II antigen presentation,' both from the University of Washington ... She has a MSc entitled 'Interleukin-2 production by transgenic Trypanosoma cruzi : molecular and biochemical characterization' ...
https://en.wikipedia.org/wiki/Anne_La_Flamme
Angiotensin II receptor type 2Angiotensin II receptor type 2
This receptor functions to mediate signaling in lung fibrosis and regulate nitric oxide synthase expression in pulmonary ... Angiotensin II receptor type 2, also known as the AT2 receptor is a protein that in humans is encoded by the AGTR2 gene. ... Angiotensin II receptor type 2 (AGTR2) gene is a protein coding gene responsible for encoding AGTR2, the integral membrane ... It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G protein-coupled receptors ...
https://en.wikipedia.org/wiki/Angiotensin_II_receptor_type_2
Endothelial NOSEndothelial NOS
Jia Z, Zhang X, Kang S, Wu Y (2013). "Association of endothelial nitric oxide synthase gene polymorphisms with type 2 diabetes ... eNOS is a dimer containing two identical monomers of 134 kD constituted by a reductase domain, which displays binding sites for ... "The polymorphism for endothelial nitric oxide synthase gene, the level of nitric oxide and the risk for pre-eclampsia: a meta- ... "Endothelial nitric oxide synthase gene polymorphisms and the risk of diabetic nephropathy in type 2 diabetes mellitus". Genetic ...
https://en.wikipedia.org/wiki/Endothelial_NOS
CGMP-specific phosphodiesterase type 5CGMP-specific phosphodiesterase type 5
"Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by ... The kinetics of inhibitor binding and inhibition of catalysis imply the existence of two PDE5 conformers, and results of native ... of PDE5 in these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of nitric oxide ... Discovered by Pfizer, sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is ...
https://en.wikipedia.org/wiki/CGMP-specific_phosphodiesterase_type_5
Type IIIType III
... a risk factor for cardiovascular disease Nitric oxide synthase 3, an enzyme Type III intermediate filaments, structural ... any of several proposed extensions to the concept of Type I and type II errors in statistics Type-III Civilization on the ... Type III or Type 3 may refer to: Type 3 Chi-Nu, a Japanese medium tank Type 3 mine, a Japanese land mine 8 cm/40 3rd Year Type ... a way to classify civilizations British Railways Type 3 Diesel locomotives The Volkswagen Type 3 Peugeot Type 3 The IBM Type- ...
https://en.wikipedia.org/wiki/Type_III
StriatumStriatum
... nitric oxide synthase and neuropeptide-y. Recently, two types of neuropeptide-y expressing GABAergic interneurons have been ... Medium spiny neurons have two characteristic types: D1-type MSNs and D2-type MSNs. A subpopulation of MSNs contain both D1-type ... Two others comprise the output to the thalamus, forming two separate channels: one through the internal segment of the globus ... Types of cells in the striatum include: Medium spiny neurons (MSNs), which are the principal neurons of the striatum. They are ...
https://en.wikipedia.org/wiki/Striatum
Angiotensin (1-7)Angiotensin (1-7)
... augmenting production of nitric oxide. Ang (1-7) contributes to the beneficial effects of ACE inhibitors and angiotensin II ... of spontaneously hypertensive rats by increasing the expression of endothelial and neuronal nitric oxide synthase enzymes, ... receptor type 1 antagonists. Santos RA, Brosnihan KB, Chappell MC, Pesquero J, Chernicky CL, Greene LJ, and Ferrario CM (1988 ... angiotensin II (Ang II). The polypeptide Ang I can be converted into Ang (1-7) by the actions of neprilysin (NEP) and thimet ...
https://en.wikipedia.org/wiki/Angiotensin_(1-7)
Caveolin 1Caveolin 1
... nitric oxide synthase 2A, epidermal growth factor receptor, endothelin receptor type B, PDGFRB, PDGFRA, PTGS2, TRAF2, estrogen ... By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single ... García-Cardeña G, Fan R, Stern DF, Liu J, Sessa WC (November 1996). "Endothelial nitric oxide synthase is regulated by tyrosine ... "Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells". ...
https://en.wikipedia.org/wiki/Caveolin_1
Argininosuccinate synthaseArgininosuccinate synthase
The enzyme endothelial nitric oxide synthase produces nitric oxide from arginine in endothelial cells. Argininosuccinate ... defects that cause incorrect localization of argininosuccinate synthetase to the outer mitochondrial membrane cause type II ... a byproduct of nitric oxide production, into arginine. Since nitric oxide is an important signaling molecule, this role of ASS ... a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase ...
https://en.wikipedia.org/wiki/Argininosuccinate_synthase
Intracranial aneurysmIntracranial aneurysm
... collagen type 1 A2, endothelial nitric oxide synthase, endothelin receptor A and cyclin dependent kinase inhibitor. Recently, ... hereditary hemorrhagic telangiectasia and Ehlers-Danlos syndrome types II and IV. Specific genes have also had reported ... Generally, about two-thirds of patients have a poor outcome, death, or permanent disability. Increased availability and greater ... Generally patients with Hunt and Hess grade I and II hemorrhage on admission to the emergency room and patients who are younger ...
https://en.wikipedia.org/wiki/Intracranial_aneurysm
David S. BredtDavid S. Bredt
Localization of nitric oxide synthase indicating a neural role for nitric oxide Nature 347, 768 - 770 (25 October 1990). Nitric ... 8, 1995 Auxiliary subunits assist AMPA-type glutamate receptors Science March, 3, 2006 Nicotinic acetylcholine receptor redux: ... PLOS ONE retracted five papers from Cassava's scientific key advisor including two papers co-authored by Cassava's vice ... Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy Cell ...
https://en.wikipedia.org/wiki/David_S._Bredt
PKIAPKIA
2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain ... 1999). "PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I". J. ... 1994). "Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms ... 99 (2): 145-149. doi:10.1016/S0169-328X(02)00104-3. PMID 11978406. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). " ...
https://en.wikipedia.org/wiki/PKIA
Tension headacheTension headache
"Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial". Lancet. 353 ( ... This classification system separates tension-type headache (TTH) into two main groups: episodic (ETTH) and chronic (CTTH). CTTH ... Briefly, the enzyme nitric oxide synthase (NOS) forms NO which ultimately results in vasodilatation and activation of central ... Tension headache, also known as stress headache, or tension-type headache (TTH), is the most common type of primary headache. ...
https://en.wikipedia.org/wiki/Tension_headache
Complications of diabetesComplications of diabetes
Montezano, A. C., & Touyz, R. M. (2012). Reactive oxygen species and endothelial function - role of nitric oxide synthase ... 2002). "Impaired NO-dependent vasodilation in patients with type II (non-insulin-dependent) by acute administration diabetes ... 2017). "Association of type 1 diabetes vs type 2 diabetes diagnosed during childhood and adolescence with complications during ... Ketoacidosis is much more common in type 1 diabetes than type 2. Nonketotic hyperosmolar coma (HNS) is an acute complication ...
https://en.wikipedia.org/wiki/Complications_of_diabetes
Nitric oxide synthaseNitric oxide synthase
The rate-limiting step for the production of nitric oxide may well be the availability of L-arginine in some cell types. This ... These two eNOS populations are distinct, but are both necessary for proper NO production and cell health. eNOS localization to ... Biological functions of nitric oxide Nitric-oxide synthase (NAD(P)H-dependent) Nitric oxide synthase 2 (inducible) PDB: 3N5P​; ... Nitric oxide synthases (EC 1.14.13.39) (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L- ...
https://en.wikipedia.org/wiki/Nitric_oxide_synthase
Testicular immunologyTesticular immunology
Other immune factors found in the testis include the enzyme inducible nitric oxide synthase (iNOS), and its product nitric ... Bauché F, Stéphan JP, Touzalin AM, Jégou B (1995). "In vitro regulation of an inducible-type NO synthase in the rat ... There are two lines of evidence that restriction of mast cell activation in the testis could be beneficial during treatment of ... O'Bryan MK, Schlatt S, Gerdprasert O, Phillips DJ, de Kretser DM, Hedger MP (2000). "Inducible nitric oxide synthase in the rat ...
https://en.wikipedia.org/wiki/Testicular_immunology
Pseudo-nitzschiaPseudo-nitzschia
P. multistriata was found to uniquely encode nitric oxide synthase. Recently, transcriptome analysis of P. multiseries was used ... Upon mixing two strains of compatible mating type and of appropriate cell size for sexualization, cells align side by side and ... sequencing of three Pseudo-nitzschia species reveals comparable gene sets and the presence of Nitric Oxide Synthase genes in ... suggesting that vegetative division is inhibited when the two strains of opposite mating type come in contact. Pseudo-nitzschia ...
https://en.wikipedia.org/wiki/Pseudo-nitzschia
Julio LicinioJulio Licinio
... type I (IL1R1), also known as CD121a (Cluster of Differentiation 121a), and inducible nitric oxide synthase (iNOS) in mammalian ... "SUNY honors two with Distinguished Faculty rank". SUNY Upstate Medical University. Archived from the original on 8 May 2019. ... "Inducible nitric oxide synthase gene expression in the brain during systemic inflammation". Nature Medicine. 2 (5): 581-584. ... Licinio, J.; Wong, M.-L. (March 1994). "Localization of interleukin 1 type I receptor mRNA in rat brain". Neuroimmunomodulation ...
https://en.wikipedia.org/wiki/Julio_Licinio
Exhaled nitric oxideExhaled nitric oxide
In humans, nitric oxide is produced from L-arginine by three enzymes called nitric oxide synthases (NOS): inducible (iNOS), ... Nitric oxide (NO) is a gaseous molecule produced by certain cell types in an inflammatory response. The fraction of exhaled NO ... endothelial (eNOS), and neuronal (nNOS). The latter two are constantly active in endothelial cells and neurons respectively, ... September 2004). "Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in ...
https://en.wikipedia.org/wiki/Exhaled_nitric_oxide
T helper cellT helper cell
In addition, IFN-γ can activate iNOS (inducible nitric oxide synthase) to produce nitric oxide free radicals to directly kill ... Type 4 hypersensitivity, also known as delayed type hypersensitivity, are caused via the over-stimulation of immune cells, ... and MHC Class II. Once at the lymph nodes, the APCs begin to present antigen peptides that are bound to Class II MHC, allowing ... Hypersensitivity reactions can be divided into four types: Type 1 hypersensitivity includes common immune disorders such as ...
https://en.wikipedia.org/wiki/T_helper_cell
TRIP13TRIP13
Schepens J, Cuppen E, Wieringa B, Hendriks W (June 1997). "The neuronal nitric oxide synthase PDZ motif binds to -G(D,E)XV* ... Yasugi T, Vidal M, Sakai H, Howley PM, Benson JD (August 1997). "Two classes of human papillomavirus type 16 E1 mutants suggest ... which has two forms (open O-Mad2 and closed C-Mad2) (2). When kinetochores are unattached, O-Mad2 converts to C-Mad2, which is ... two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase". ...
https://en.wikipedia.org/wiki/TRIP13
AviptadilAviptadil
... in the mucosa and submucosa are non-cholinergic secretomotor neurons and well colocalized with neuronal nitric oxide synthase ( ... VIP is highly localised in lungs and binds with alveolar type II (AT II) cells via VPAC1 receptor. AT II cells constitute only ... VIP is highly localised in lungs (70%) and binds with alveolar type II (AT II) cells via VPAC1. The biological (vasodilator) ... AT II cells produces surfactant and plays an important role in the maintenance of type 1epithelial cells. SARS-CoV-2 enters ...
https://en.wikipedia.org/wiki/Aviptadil
Long-term impact of alcohol on the brainLong-term impact of alcohol on the brain
These transcription factors cause the upregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) ... and intermediate types, while not affecting early neuronal type cells; suggesting ethanol treatment alters the precursor cell ... One of the proposed mechanisms for alcohol's neurotoxicity is the production of nitric oxide (NO), yet other studies have found ... Blanco Am, V. S. S.; Vallés, S. L.; Pascual, M.; Guerri, C. (2005). "Involvement of TLR4/type I IL-1 receptor signaling in the ...
https://en.wikipedia.org/wiki/Long-term_impact_of_alcohol_on_the_brain
Neuronal calcium sensor-1Neuronal calcium sensor-1
A type (Kv4.3; Shal-related subfamily, member 3) voltage-gated potassium channels Nitric oxide synthase TRPC5 channel Ric8a Frq ... NCS-1 also contains at least two known protein binding domains, and a large surface exposed hydrophobic crevice containing EF- ... The designation 'NCS-1' came from the assumption that the protein was expressed only in neuronal cell types, which is not the ... type III phosphatidylinositol 4-kinase β) IP3 receptor (this activity is inhibited by lithium - a drug used for the treatment ...
https://en.wikipedia.org/wiki/Neuronal_calcium_sensor-1
Granule cellGranule cell
Nitric oxide Granule neurons have high levels of the neuronal isoform of nitric oxide synthase. This enzyme is dependent on the ... There are two types of excitatory inputs received by GABAergic granule cells; those activated by an AMPA receptor and those ... Each granule cell is receiving an input from two different mossy fiber inputs. The input is thus coming from two different ... The principal cell type of the dentate gyrus is the granule cell. The dentate gyrus granule cell has an elliptical cell body ...
https://en.wikipedia.org/wiki/Granule_cell
ARG2ARG2
... arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line". FEBS Letters. ... it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from ... At least two isoforms of mammalian arginase exists (types I and II, this enzyme) which differ in their tissue distribution, ... Arginase, type II is an arginase protein that in humans is encoded by the ARG2 gene. Arginase catalyzes the hydrolysis of ...
https://en.wikipedia.org/wiki/ARG2
DYNLL1DYNLL1
Yu J, Yu L, Chen Z, Zheng L, Chen X, Wang X, Ren D, Zhao S (Mar 2002). "Protein inhibitor of neuronal nitric oxide synthase ... They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal ... "Entrez Gene: DYNLL1 dynein, light chain, LC8-type 1". Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, Huang DC ... Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it ...
https://en.wikipedia.org/wiki/DYNLL1
Protein detoxificationProtein detoxification
Asymmetrically methylated arginine forms (AMAF) inhibit nitric oxide synthase and the formation of nitric oxide (NO), also ... Two types of PMRTs have been characterised. Type 1 PRMTs are found mainly in endothelial and smooth muscle cells and produce ... Endogenous production of nitric oxide synthase inhibitors Vascular Medicine 2005; 10: S3-9 Palm, F. Dimethylarginine ... Indeed, by protecting the vessel against vasoconstriction nitric oxide has been referred to as the fountain of youth. It also ...
https://en.wikipedia.org/wiki/Protein_detoxification
Plasma membrane Ca2+ ATPasePlasma membrane Ca2+ ATPase
Isoform PMCA4b interacts with nitric oxide synthase and reduces synthesis of nitric oxide by that enzyme. PMCA isoform 4 has a ... Thus the activities of the two types of pump complement each other. The PMCA functions in a similar manner to other p-type ion ... a major regulator of nitric oxide synthase I". J. Cell Biol. 155 (2): 201-205. doi:10.1083/jcb.200104131. PMC 2198825. PMID ... PMCA types 1, 2, and 4 have been found in glial cells called astrocytes in mammals, though it was previously thought that only ...
https://en.wikipedia.org/wiki/Plasma_membrane_Ca2 _ATPase
Acute tubular necrosisAcute tubular necrosis
"Coexpressed nitric oxide synthase and apical beta(1) integrins influence tubule cell adhesion after cytokine-induced injury". ... Diagnosis is made by a FENa (fractional excretion of sodium) > 3% and presence of muddy casts (a type of granular cast) in ... Molecular nephrology: types of acute tubular injury. Nat Rev Nephrol 15, 599-612 (2019). https://doi.org/10.1038/s41581-019- ... doi:10.1016/S0272-6386(03)00214-2. PMID 12778436. (Wikipedia articles needing page number citations from September 2010, ...
https://en.wikipedia.org/wiki/Acute_tubular_necrosis
Enzyme inhibitorEnzyme inhibitor
... application to nitric oxide synthase". AAPS PharmSci. 2 (1): 68-77. doi:10.1208/ps020108. PMC 2751003. PMID 11741224. Loo JA, ... 97 Mixed-type inhibitors bind to both E and ES, but their affinities for these two forms of the enzyme are different (Ki ≠ Ki ... Cleland WW (February 1963). "The kinetics of enzyme-catalysed reactions with two or more substrates or products. II. Inhibition ... 381-382 Although it is possible for mixed-type inhibitors to bind in the active site, this type of inhibition generally results ...
https://en.wikipedia.org/wiki/Enzyme_inhibitor
HSPA8HSPA8
Kiang JG (Dec 2004). "Inducible heat shock protein 70 kD and inducible nitric oxide synthase in hemorrhage/resuscitation- ... The ATP binding domain consists of four subdomains split into two lobes by a central ATP/ADP binding pocket. The two terminal ... Furlini G, Vignoli M, Re MC, Gibellini D, Ramazzotti E, Zauli G, La Placa M (Jan 1994). "Human immunodeficiency virus type 1 ... The substrate-binding domain consists of two subdomains, a two-layered β-sandwich subdomain (SBDβ) and an α-helical subdomain ( ...
https://en.wikipedia.org/wiki/HSPA8
HemeHeme
Alderton, W.K. (2001). "Nitric oxide synthases: structure, function and inhibition". Biochem. J. 357 (3): 593-615. doi:10.1042/ ... Thus cytochrome oxidase, which has two A hemes (heme a and heme a3) in its structure, contains two moles of heme A per mole ... There are several biologically important kinds of heme: The most common type is heme B; other important types include heme A ... and endothelial nitric oxide synthase. The word haem is derived from Greek αἷμα haima meaning "blood". Hemoproteins have ...
https://en.wikipedia.org/wiki/Heme
Lipid signalingLipid signaling
Specifically in blood vessels, the increase in Ca2+ concentration from IP3 releases nitric oxide, which then diffuses into the ... Treatment of HL60 cells (a type of leukemia cell line) by a plant-derived organic compound called phorbol ester increased Sph ... C1P carry ionic charge at neutral pH and contain two hydrophobic chains making it relatively insoluble in aqueous environment. ... 1995). "Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals". Cell ...
https://en.wikipedia.org/wiki/Lipid_signaling
PimagedinePimagedine
... functions as an inhibitor of diamine oxidase and nitric oxide synthase. It acts to reduce levels of advanced ... type II) diabetes patients with overt nephropathy, after the trial's external safety monitoring committee found an increased ... With formic acid, a cyclization takes place to give 3-amino-1,2,4-triazole. The compound reacts with nitrous acid in acidic ... cease development of pimagedine as a treatment for end stage renal disease but might consider continuing development in type 1 ...
https://en.wikipedia.org/wiki/Pimagedine
ATG9BATG9B
"Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non ... Ban HJ, Heo JY, Oh KS, Park KJ (2010). "Identification of type 2 diabetes-associated combination of SNPs using support vector ... "Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in ... gene also functions as an antisense transcript in the post-transcriptional regulation of the endothelial nitric oxide synthase ...
https://en.wikipedia.org/wiki/ATG9B
Vascular remodelling in the embryoVascular remodelling in the embryo
Endothelial nitric oxide synthase (eNOS), promotes unidirectional flow at the onset of heart beats and is upregulated by shear ... This type of vessel breakage may even be indirectly responsible for the development of some organ systems and the evolution of ... At locations inside the vessel where two tube split off from one, one arm of the split is likely to close, detach, and migrate ... Shear stress is proportional to the speed inside the vessel as well as the pressure drop between two fixed points on the vessel ...
https://en.wikipedia.org/wiki/Vascular_remodelling_in_the_embryo
P450-containing systemsP450-containing systems
Allene oxide synthase (CYP74A; EC 4.2.1.92), fatty acid hydroperoxide lyase (CYP74B), prostacyclin synthase (CYP8; EC 5.3.99.4 ... This enzyme does not have monooxygenase activity but is able to reduce nitric oxide (NO·) to form nitrous oxide (N2O) directly ... of FMN-binding domain and C-terminal plant-type ferredoxin domain. Similar systems have been identified in the heavy-metal- ... The general scheme of electron flow in this system appears to be: Nitric oxide reductase (P450nor) is a P450 enzyme involved in ...
https://en.wikipedia.org/wiki/P450-containing_systems
Low-density lipoprotein receptor-related protein 8Low-density lipoprotein receptor-related protein 8
Sacre SM, Stannard AK, Owen JS (2003). "Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in ... Upon reelin binding, Dab1 is phosphorylated by two tyrosine kinases, Fyn and Src. The phosphorylated Dab1 then causes further ... There is also speculation that the antibody/β2GPI complexes sensitize other cell types through various LDL family receptors to ... PI3K activation leads to inhibitory phosphorylation of the tau kinase glycogen synthase kinase 3 beta (GSK3B), which alters the ...
https://en.wikipedia.org/wiki/Low-density_lipoprotein_receptor-related_protein_8
Syed Ziaur RahmanSyed Ziaur Rahman
"Nitric oxide synthase activity and the level of nitrates/nitrites in brain regions during spontaneous morphine withdrawal in ... "A novel lupene-type triterpenic glucoside from the leaves of Clerodendrum inerme". Natural Product Research. 24 (2): 167-176. ... "Nitric oxide synthase activity and the level of nitrates/nitrites in brain regions during spontaneous morphine withdrawal in ... "Effects of morphine withdrawal on the indices of free radical homeostasis and nitric oxide system in rat liver and thymus". ...
https://en.wikipedia.org/wiki/Syed_Ziaur_Rahman
Valina L. DawsonValina L. Dawson
1996). "Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice". J. Neurosci. 16 ( ... 1993). "Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures". ... "Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease". Nature ... 1991). "Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures". Proc Natl Acad Sci U S A. 88 (14): 6368- ...
https://en.wikipedia.org/wiki/Valina_L._Dawson
Cystathionine beta synthaseCystathionine beta synthase
The Fe2+ form of the enzyme is inhibited upon binding CO or nitric oxide, whereas enzyme activity is doubled when the Fe2+ is ... 1995). "Two novel missense mutations in the cystathionine beta-synthase gene in homocystinuric patients". Hum. Genet. 96 (2): ... Homocystinuria due to CBS deficiency is a special type of hyperhomocysteinemia. It is a rare, hereditary recessive autosomal ... "Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations ...
https://en.wikipedia.org/wiki/Cystathionine_beta_synthase
Endocannabinoid transporterEndocannabinoid transporter
Activation of CB1 enhances AMT activity through increased nitric oxide synthase (NOS) activity and subsequent increase of NO ... dependent modulation of type 1 cannabinoid receptors in nerve cells". Journal of Neuroscience Research. 81 (2): 275-283. doi: ... 134 (2): 131-139. doi:10.1016/j.chemphyslip.2004.12.010. PMID 15784231. Di Pasquale, E.; Chahinian, H.; Sanchez, P.; Fantini, J ... The endocannabinoids (anandamide, AEA, and 2-arachidonoylglycerol, 2-AG) on the other hand, are non-charged lipids that readily ...
https://en.wikipedia.org/wiki/Endocannabinoid_transporter
Coronary vasospasmCoronary vasospasm
... these agents work by enhancing the production of nitric oxide from endothelial nitric oxide synthase. Normally, nitric oxide ... described a type of chest pain resulting from coronary vasospasm, referring to it as a variant form of classical angina ... Vasodilatory agents with mechanisms dependent on a functional endothelial nitric oxide synthase can cause vasoconstriction ... Endothelial dysfunction wherein there is a deficiency in the production of nitric oxide has been found to be associated with ...
https://en.wikipedia.org/wiki/Coronary_vasospasm
Integrated stress responseIntegrated stress response
Lu, Wei; László, Csaba F.; Miao, Zhixin; Chen, Hao; Wu, Shiyong (4 September 2009). "The Role of Nitric-oxide Synthase in the ... This complex contains a PP1 catalytic subunit as well as two regulatory subunits. This complex is negatively regulated by two ... thus creating specific responses to different types of stressors. When a cell is undergoing the stress of hypoxia, ATF4 will ... HRI has two domains that heme may bind to, including one on the N-terminus and one on the kinase insertion domain. The presence ...
https://en.wikipedia.org/wiki/Integrated_stress_response
Retrograde signalingRetrograde signaling
... nitric oxide (NO) is a soluble gas that can readily diffuse through various cell membranes. Nitric oxide synthase is the enzyme ... O'Dell TJ, Hawkins RD, Kandel ER, Arancio O (December 1991). "Tests of the roles of two diffusible substances in long-term ... In cell biology, this type of signaling typically occurs between the mitochondria or chloroplast and the nucleus. Signaling ... and nitric oxide. Nitric oxide has received a great deal of attention in the past, but has recently been superseded by adhesion ...
https://en.wikipedia.org/wiki/Retrograde_signaling
SGCBSGCB
2002). "Localization of sarcoglycan, neuronal nitric oxide synthase, beta-dystroglycan, and dystrophin molecules in normal ... 2000). "Disruption of the beta-sarcoglycan gene reveals pathogenetic complexity of limb-girdle muscular dystrophy type 2E" (PDF ... missense mutations may cause severe limb-girdle muscular dystrophy type 2E (LGMD 2E)". Hum Mol Genet. 5 (12): 1953-61. doi: ... 48 (2): 145-56. doi:10.1006/geno.1997.5160. PMID 9521867. Duclos F, Broux O, Bourg N, et al. (1998). "Beta-sarcoglycan: genomic ...
https://en.wikipedia.org/wiki/SGCB
GRIN3BGRIN3B
... evidence for involvement of NMDA receptors and nitric oxide synthase". Virology. 226 (2): 362-73. doi:10.1006/viro.1996.0664. ... 1999). "Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a ... Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome ... human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and ...
https://en.wikipedia.org/wiki/GRIN3B
Murine respirovirusMurine respirovirus
... such as type I and type II IFN signaling, as well as cytokine signaling. Among the ten most virus-induced mRNAs are IFNα8, IFN ... Morita N, Tanaka Y, Odkhuu E, Naiki Y, Komatsu T, Koide N (February 2020). "Sendai virus V protein decreases nitric oxide ... Xu W, Kozak CA, Desnick RJ (April 1995). "Uroporphyrinogen-III synthase: molecular cloning, nucleotide sequence, expression of ... such as type I and type II IFN signaling, as well as cytokine signaling. Among the ten most virus-induced mRNAs are IFNα8, IFN ...
https://en.wikipedia.org/wiki/Murine_respirovirus
HydroxocobalaminHydroxocobalamin
Medicine portal Methylcobalamin Cyanocobalamin Adenosylcobalamin Vitamin B12 Cobalamin biosynthesis Nitric oxide " ... Commercially it is made using one of a number of types of bacteria. Standard therapy for treatment of vitamin B12 deficiency ... Hydroxocobalamin has a higher affinity to the TC II transport protein than cyanocobalamin, or 5-deoxyadenosylcobalamin. From a ... In the other enzymatic reaction, methylcobalamin supports the methionine synthase reaction, which is essential for normal ...
https://en.wikipedia.org/wiki/Hydroxocobalamin
NMDA receptorNMDA receptor
As well as preventing methamphetamine-induced neurotoxicity via inhibition of nitric oxide synthase (nNOS) expression and ... The NMDA receptor is one of three types of ionotropic glutamate receptors, the other two being AMPA and kainate receptors. ... NMDA receptors are heterotetramers with two GluN1 subunits and two variable subunits. Two of these variable subunits, GluN2A ... Functional NMDA receptors are heterotetramers composed of two GluN1 and typically two GluN2 subunits. There is one GluN1, four ...
https://en.wikipedia.org/wiki/NMDA_receptor
Interleukin 13Interleukin 13
... production of inducible nitric oxide synthase by airway epithelial cells, activation of macrophages, permeability of the ... IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, ... Once, in the nucleus, STAT6 heterodimer molecule regulates gene expression of cell types critical to the balance between host ... IL-13 has been shown to induce a potent fibrogenic program during the course of diverse diseases marked by elevated Type 2 ...
https://en.wikipedia.org/wiki/Interleukin_13
ADCY10ADCY10
Marjanovic JA, Li Z, Stojanovic A, Du X (2006). "Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet ... 1998). "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in ... 3.0.CO;2-M. PMID 10737962. S2CID 34539645. Chen Y, Cann MJ, Litvin TN, et al. (2000). "Soluble adenylyl cyclase as an ...
https://en.wikipedia.org/wiki/ADCY10
CannabidiolCannabidiol
"Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa". FEBS Letters. 581 (16): 2929- ... Nitric Oxide. 111-112: 45-63. doi:10.1016/j.niox.2021.04.001. PMID 33838343. S2CID 233205099. Russo EB (February 2008). " ... It was approved in 2018, by the US Food and Drug Administration (FDA) for treatment of two rare forms of childhood epilepsy, ... where CBDA synthase performs catalysis instead of THCA synthase. In the typical operating temperature range of e-cigarettes ( ...
https://en.wikipedia.org/wiki/Cannabidiol
Secondary hypertensionSecondary hypertension
"Nitric oxide and cardiovascular effects: new insights in the role of nitric oxide for the management of osteoarthritis". ... August 2008). "Further evidence for linkage of familial hyperaldosteronism type II at chromosome 7p22 in Italian as well as ... the Gene mutated will result in an aldosterone synthase that is ACTH-sensitive, which is normally not. GRA appears to be the ... It seems that inhibition of nitric oxide synthesis may also play a role in cortisol induced hypertension. Yet another related ...
https://en.wikipedia.org/wiki/Secondary_hypertension
Nitric Oxide Synthase Type II | Profiles RNS
"Nitric Oxide Synthase Type II" by people in this website by year, and whether "Nitric Oxide Synthase Type II" was a major or ... "Nitric Oxide Synthase Type II" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Nitric Oxide Synthase Type II" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Nitric Oxide Synthase Type II". ...
https://profiles.musc.edu/display/103839/
IMSEAR at SEARO: Endothelial nitric oxide synthase (eNOS) VNTR as a probable marker in type 2 diabetes mellitus.
Endothelial nitric oxide synthase (eNOS) VNTR as a probable marker in type 2 diabetes mellitus. International Archives of ... Endothelial nitric oxide synthase. eNOS. Type 2 diabetes mellitus. 27 bp VNTR polymorphism. north Indian population. ... Endothelial nitric oxide synthase (eNOS) VNTR as a probable marker in type 2 diabetes mellitus. ... Generally, in diabetes there are numerous genes involved, each being a small contributor in type 2 diabetes mellitus (T2DM) ...
https://imsear.searo.who.int/handle/123456789/164604
Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior...Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior...
Nitric Oxide / metabolism * Nitric Oxide / urine * Nitric Oxide Synthase Type II / metabolism ... Methods: Time courses for development of gut hyperpermeability, nitric oxide production, oxidative injury to the gut, ... Results: Liver fat and serum transaminase increased after 2 weeks, but evidence of liver cell injury and inflammation (ASH) ... Gut leakiness, intestinal oxidative injury, and endotoxemia occurred in weeks 2-4 and progressed thereafter. ...
https://pubmed.ncbi.nlm.nih.gov/19155080/?dopt=Abstract
Inducible nitric oxide synthase expression inhibition by adenovirus E1A<...
Nitric Oxide Synthase Type II Medicine & Life Sciences 100% * Adenoviridae Medicine & Life Sciences 92% ... title = "Inducible nitric oxide synthase expression inhibition by adenovirus E1A",. abstract = "Nitric oxide (NO) is an ... Inducible nitric oxide synthase expression inhibition by adenovirus E1A. Proceedings of the National Academy of Sciences of the ... Inducible nitric oxide synthase expression inhibition by adenovirus E1A. / Cao, Wangsen; Bao, Clare; Lowenstein, Charles J. ...
https://jhu.pure.elsevier.com/en/publications/inducible-nitric-oxide-synthase-expression-inhibition-by-adenovir-4
NIOSHTIC-2 Search Results - Full View
Nitric oxide synthase type II; Occupational exposure; Parkinsonian disorders; Welding ... Inducible nitric oxide synthase, coded by NOS2, is involved in inflammation, and particulate exposure increases the genes ... Inducible nitric oxide synthase gene methylation and parkinsonism in manganese-exposed welders. ... Inflammation mediated by inducible nitric oxide synthase may possibly contribute to the association between welding fume and ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=manganese&f1=%2A&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=14&RecNo=135&View=f&
Leptin in the interplay of inflammation, metabolism and immune system disorders | Nature Reviews RheumatologyLeptin in the interplay of inflammation, metabolism and immune system disorders | Nature Reviews Rheumatology
Otero, M., Gomez Reino, J. J. & Gualillo, O. Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin ... Otero, M., Lago, R., Lago, F., Reino, J. J. G. & Gualillo, O. Signalling pathway involved in nitric oxide synthase type II ... Type 1 T helper cells. (TH1 cells). Subset of helper-inducer T-lymphocytes that synthesize and secrete IL-2, IFNγ and IL-12. ... Owing to their ability to kill antigen-presenting cells, TH1 cells are associated with vigorous delayed-type hypersensitivity ...
https://www.nature.com/articles/nrrheum.2016.209?error=cookies_not_supported&code=22e9b86f-650f-429a-a7ef-b50edcb66362
Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury.<...Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury.<...
Nitric Oxide Synthase Type II Medicine & Life Sciences 72% * Reperfusion Injury Medicine & Life Sciences 66% ... Nitric oxide (NO), produced via inducible nitric oxide synthase (iNOS), is implicated in the pathophysiology of renal ischemia/ ... Nitric oxide (NO), produced via inducible nitric oxide synthase (iNOS), is implicated in the pathophysiology of renal ischemia/ ... Nitric oxide (NO), produced via inducible nitric oxide synthase (iNOS), is implicated in the pathophysiology of renal ischemia/ ...
https://abdn.pure.elsevier.com/en/publications/inhibition-of-inducible-nitric-oxide-synthase-reduces-renal-ische
Prophylactic gene therapy with human tissue kallikrein ameliorates limb ischemia recovery in type 1 diabetic mice<...Prophylactic gene therapy with human tissue kallikrein ameliorates limb ischemia recovery in type 1 diabetic mice<...
Nitric Oxide Synthase, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III, Reference Values, Time Factors, Tissue ... KW - Nitric Oxide Synthase. KW - Nitric Oxide Synthase Type II. KW - Nitric Oxide Synthase Type III ... Nitric Oxide Synthase. *Nitric Oxide Synthase Type II. *Nitric Oxide Synthase Type III ... and upregulated endothelial nitric oxide synthase expression. Ultimately, correction of diabetic endotheliopathy by Ad.hTK ...
https://research-information.bris.ac.uk/en/publications/prophylactic-gene-therapy-with-human-tissue-kallikrein-ameliorate
Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute...Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute...
Nitric Oxide Synthase Type II Medicine & Life Sciences 87% * Nitric Oxide Synthase Medicine & Life Sciences 71% ... N2 - The inducible isoform of nitric oxide synthase (iNOS) is expressed in various organs, including the lung, during systemic ... AB - The inducible isoform of nitric oxide synthase (iNOS) is expressed in various organs, including the lung, during systemic ... The inducible isoform of nitric oxide synthase (iNOS) is expressed in various organs, including the lung, during systemic ...
https://researchexperts.utmb.edu/en/publications/selective-inhibition-of-the-inducible-isoform-of-nitric-oxide-syn
RePub, Erasmus University Repository: Genetic variation in the NOS1AP gene is associated with the incidence of diabetes...RePub, Erasmus University Repository: Genetic variation in the NOS1AP gene is associated with the incidence of diabetes...
Nitric oxide synthase, Pharmacogenetics Persistent URL doi.org/10.1007/s00125-008-1143-4, hdl.handle.net/1765/29099 ... Calcium channel blocker, Diabetes mellitus type 2, ...
https://repub.eur.nl/pub/29099
Fernand Pierre Gendron - Spécialistes - Recherche - Université de Sherbrooke - Université de SherbrookeFernand Pierre Gendron - Spécialistes - Recherche - Université de Sherbrooke - Université de Sherbrooke
2003). P2X7 nucleotide receptor activation enhances IFN gamma-induced type II nitric oxide synthase activity in BV-2 microglial ... 1999). Identification and immunolocalization of two isoforms of ATP-diphosphohydrolase (ATPDase) in the pig immune system. ... Étude sur le diabète de type 2 : exposition au froid ou activité physique? ... PLoS One 10 (2), e0117238. (Published). * *Vinette V, *Placet M, Arguin G, Gendron FP. (2015). Multidrug resistance-associated ...
https://www.usherbrooke.ca/recherche/specialistes/details/fernand-pierre.gendron
Rochester, MN - Research output - Mayo Clinic
Nitric Oxide Synthase Type II 52% * Animal Disease Models 32% * Kupffer Cells 29% ... Nitric oxide: What role does it play in inflammation and tissue destruction. Evans, C. H., 1995, In: Agents and Actions ... Topoisomerase II as a target for anticancer chemotherapy.. Kaufmann, S. H. & Hancock, R., 1995, In: Acta biochimica Polonica. ... Meyer, F. B., Morita, A., Puumala, M. R. & Nichols, D. A., 1995, In: Mayo Clinic proceedings. 70, 2, p. 153-172 20 p.. Research ...
https://mayoclinic.pure.elsevier.com/en/organisations/rochester-mn/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Fsystematicreview&ordering=publicationYearThenTitle&descending=true&page=267
Osteoartritis, obesidad e inflamación
A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in ...
https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=50776
Severity of Osteoarthritis Is Associated with Increased Arterial StiffnessSeverity of Osteoarthritis Is Associated with Increased Arterial Stiffness
M. Otero, J. J. Gomez Reino, and O. Gualillo, "Synergistic induction of nitric oxide synthase type II: in vitro effect of ... The Mann-Whitney U test was used for comparing means between two groups. Continuous variables are presented as mean ± SD. Since ... General characteristics of the two study groups are presented in Table 1. The level of BMI and the W/H-ratio were significantly ... The radiographs were evaluated independently by two raters blinded to the clinical data and a consensus score was produced. ...
https://www.hindawi.com/journals/ijr/2016/6402963/
Catalytic intermediates of inducible nitric-oxide synthase stabilized by the W188H mutation<...Catalytic intermediates of inducible nitric-oxide synthase stabilized by the W188H mutation<...
Nitric Oxide Synthase Type II Medicine & Life Sciences 95% * Mutation Chemical Compounds 76% ... N2 - Nitric-oxide synthase (NOS) catalyzes nitric oxide (NO) synthesis via a two-step process: L-arginine (L-Arg) → N-hydroxy- ... AB - Nitric-oxide synthase (NOS) catalyzes nitric oxide (NO) synthesis via a two-step process: L-arginine (L-Arg) → N-hydroxy- ... Nitric-oxide synthase (NOS) catalyzes nitric oxide (NO) synthesis via a two-step process: L-arginine (L-Arg) → N-hydroxy- ...
https://einstein.pure.elsevier.com/en/publications/catalytic-intermediates-of-inducible-nitric-oxide-synthase-stabil-2
Department of Anesthesiology - Research output - Taipei Medical University
Nitric Oxide Synthase Type II 93% * Tristetraprolin 26% * Enzyme Stability 23% * Enzyme Induction 20% ... Cirrhosis patients stroke risks and adverse outcomes: Two nationwide studies. Wu, H. Y., Lin, C. S., Yeh, C. C., Hu, C. J., ... Clonidine enhances type-2 cationic amino acid transporter transcription in endotoxin-activated murine macrophages. Lai, Y. C., ... Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in terms of major ...
https://tmu.pure.elsevier.com/en/organisations/department-of-anesthesiology-2/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=type&descending=true&page=2
US Patent for 1,2,4-oxa diazolino and 1,24-oxa diazolidion heterocycles as useful nitric oxide synthase inhibitors Patent ...US Patent for 1,2,4-oxa diazolino and 1,24-oxa diazolidion heterocycles as useful nitric oxide synthase inhibitors Patent ...
4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors. ... Type: Grant Filed: Jan 14, 1999. Date of Patent: Sep 28, 1999. Assignee: G.D. Searle & Co. (Chicago, IL) Inventors: Donald W. ... nitric oxide synthesis produced by inducible NO synthase over nitric oxide produced by the constitutive forms of NO synthase in ... 24-oxa diazolidion heterocycles as useful nitric oxide synthase inhibitors Patent (Patent # 5,958,958) 1,2,4-oxa diazolino and ...
https://patents.justia.com/patent/5958958
轉譯醫學博士學位學程 - 研究成果 - 臺
Nitric Oxide Synthase Type II 67% * Blood Vessels 50% 38 引文 斯高帕斯（Scopus） ... Outcomes of adjuvant oral versus intravenous fluoropyrimidines for high-risk stage II or stage III colon adenocarcinoma: A ... 許明暉(Min-Huei H, 李友專(Yu-Chuan L, 邱文達(Wen-Ta C & 顏如娟, 2005, 於: 北市醫學雜誌. 2, 3, p. 272-277 6 p.. 研究成果: 雜誌貢獻 › 文章 › 同行評審 ... Wang, Y. J., Lee, C. C., Chang, W. C., Liou, H. B. & Ho, Y. S., 6月 20 2001, 於: Toxicology Letters. 122,
https://tmu.pure.elsevier.com/zh/organisations/the-phd-program-for-translational-medicine-2/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=title&descending=false&page=24
Withaferin A Inhibits Nuclear Factor- B-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes<...
Nitric Oxide Synthase Type II Medicine & Life Sciences 41% * Cyclooxygenase 2 Medicine & Life Sciences 41% ... and inducible nitric oxide synthase (iNOS). Since the steroid lactone Withaferin A was described to inhibit NF-B activity in ... and inducible nitric oxide synthase (iNOS). Since the steroid lactone Withaferin A was described to inhibit NF-B activity in ... and inducible nitric oxide synthase (iNOS). Since the steroid lactone Withaferin A was described to inhibit NF-B activity in ...
https://moh-it.pure.elsevier.com/en/publications/withaferin-a-inhibits-nuclear-factor-b-dependent-pro-inflammatory
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory...
Nitric Oxide Synthase Type II Medicine & Life Sciences 36% * NAD Medicine & Life Sciences 23% ... of inducible nitric oxide synthase (iNOS) and of cyclooxygenase 2 in mouse macrophages. Here, we show that these analogues are ... of inducible nitric oxide synthase (iNOS) and of cyclooxygenase 2 in mouse macrophages. Here, we show that these analogues are ... of inducible nitric oxide synthase (iNOS) and of cyclooxygenase 2 in mouse macrophages. Here, we show that these analogues are ...
https://discovery.dundee.ac.uk/en/publications/extremely-potent-triterpenoid-inducers-of-the-phase-2-response-co
Choosing Among Type II Diabetes Mouse ModelsChoosing Among Type II Diabetes Mouse Models
BKS-db/db mice that carry a targeted mutation in nitric oxide synthase 3, eNOS (BKS.Cg-Leprdb Nos3tm1Unc/RhrsJ (008340)) ... Choosing Among Type II Diabetes Mouse Models. By Jim Yeadon, Ph.D. ... JAX has been distributing mouse models for type II diabetes (Non-insulin Dependent Diabetes; NIDD; T2D) since the 1960s, and ... Phase II: Fasting hyperglycemia and significant beta cell atrophy.. • Phase III (end stage): Beta cells can no longer release ...
https://www.jax.org/news-and-insights/jax-blog/2015/July/choosing-among-type-ii-diabetes-mouse-models
Novel role of the nitrite transporter NirC in Salmonella pathogenesis: SPI2-dependent suppression of inducible nitric oxide...
Nitric Oxide Synthase Type II Medicine & Life Sciences 96% * Salmonella Medicine & Life Sciences 95% ... T2 - SPI2-dependent suppression of inducible nitric oxide synthase in activated macrophages ... SPI2-dependent suppression of inducible nitric oxide synthase in activated macrophages. Microbiology (United Kingdom), 155(8), ... SPI2-dependent suppression of inducible nitric oxide synthase in activated macrophages, Microbiology (United Kingdom), vol. ...
https://scholars.mssm.edu/en/publications/novel-role-of-the-nitrite-transporter-nirc-in-salmonella-pathogen-2
Office of Research - Research output - Research Nebraska
Nitric Oxide Synthase Type II 96% * Permeability 78% * Lipopolysaccharides 78% 65 Scopus citations ... VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/cGMP-dependent pathway. Mayhan, W. G., 1999 ... Role of inducible nitric oxide synthase. Mayhan, W. G., May 11 1998, In: Brain Research. 792, 2, p. 353-357 5 p.. Research ... Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: Role of GABA. Zhang, K. & Patel ...
https://experts.nebraska.edu/en/organisations/office-of-research/publications/?page=247
Sonja Klebe - Research output - Research @ Flinders
Nitric Oxide Synthase Type II 100% * Iris 74% * Uveitis 45% * Cross Reactions 16% ... Molecular and clinical spectrum of type I plasminogen deficiency: a series of 50 patients. Tefs, K., Gueorguieva, M., Klammt, J ... Klebe, S., Mead, K., Brennan, J., Skinner, J., Sykes, P. & Allen, P., 2006, In: Pathology. 38, 4, p. 382-383 2 p.. Research ... Roberts, A., Rees, M., Klebe, S., Fletcher, J. & Byers, S., 2007, In: Molecular Genetics and Metabolism. 92, 1-2, p. 115-121 7 ...
https://researchnow.flinders.edu.au/en/persons/sonja-klebe-2/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&page=2&ordering=publicationYearThenTitle&descending=true
Ralph A Defronzo - Research output - Scholars @ UT Health San AntonioRalph A Defronzo - Research output - Scholars @ UT Health San Antonio
Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects. ... In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension. Bonora, E., Bonadonna, R. C., ... Insulin-induced hexokinase II expression is reduced in obesity and NIDDM. Pendergrass, M., Koval, J., Vogt, C., Yki-Jarvinen, H ... Insulin reduces plasma arginase activity in type 2 diabetic patients. Kashyap, S. R., Lara, A., Zhang, R., Young, M. P. & ...
https://scholars.uthscsa.edu/en/persons/ralph-a-defronzo/publications/?ordering=type&descending=false&page=7
DeCSDeCS
Inducible Nitric Oxide Synthase NOS II NOS-II Nitric Oxide Synthase II Nitric Oxide Synthase, Type II ... Inducible Nitric Oxide Synthase. NOS II. NOS-II. Nitric Oxide Synthase II. Nitric Oxide Synthase, Type II. ... 2006; INDUCIBLE NITRIC OXIDE SYNTHASE was indexed under NITRIC-OXIDE SYNTHASE 1998-2005; NITRIC OXIDE SYNTHASE II was indexed ... Nitric Oxide Synthase Type II - Preferred Concept UI. M0284733. Scope note. A CALCIUM-independent subtype of nitric oxide ...
https://decs.bvsalud.org/en/ths/resource/?id=50642
Nitric Oxide Synthase Type III - Endothelial Nitric Oxide Synthase Summary | CureHunter MobileNitric Oxide Synthase Type III - Endothelial Nitric Oxide Synthase Summary | CureHunter Mobile
Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase) * Messenger RNA (mRNA) ... Endothelial Nitric Oxide Synthase; ECNOS Enzyme; ENOS Enzyme; Endothelial Constitutive Nitric Oxide Synthase; Nitric Oxide ... Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase) Summary Description: A CALCIUM-dependent, constitutively- ... Drugs Related to Nitric Oxide Synthase Type III. * Nitric Oxide (Nitrogen Monoxide) ...
https://curehunter.com/m/keywordSummaryD052250.do
AJOU Open Repository: Browsing DSpaceAJOU Open Repository: Browsing DSpace
Nitric Oxide Synthase Type II. All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
http://repository.ajou.ac.kr/handle/201003/14365/browse?type=subject&order=ASC&rpp=60&value=Nitric+Oxide+Synthase+Type+II
NIOSHTIC-2 Search Results - Basic View
Diesel exhaust particle-induced oxidant injury and cellular responses in wild type and inducible nitric oxide synthase- ... An epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide ... Hydrogen peroxide mediates the apoptotic effect of cisplatin by downregulating bcl-2 through ubiquitin-proteasomal degradation. ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=hydrogen+peroxide&f1=%2A&Adv=0&terms=1&PageNo=66&RecNo=66&View=b&
Dietary phytosterols and phytostanols decrease cholesterol levels but increase blood pressure in WKY inbred rats in the absence...Dietary phytosterols and phytostanols decrease cholesterol levels but increase blood pressure in WKY inbred rats in the absence...
... angiotensin II receptor type 1a (Agtr1a), nitric oxide synthase 1, 3 (Nos1, Nos3), cyclooxygenase 2, Spondin 1 and THUMP domain ... angiotensin II receptor 1a (Agtr1a), nitric oxide synthases (Nos) 1, Nos3, Cyclooxygenase 2, Spondin 1 and Thump domain 1 (P , ... The renin-angiotensin-aldosterone system, prostanoids system, nitric oxide system, Spondin 1 and THUMP domain containing 1 do ... nitric oxide, and cyclooxygenase-derived prostanoid pathways were investigated (Table 5). Spondin 1 and THUMP domain containing ...
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-7-11
InhibitionMacrophagesMiceENOSInflammationNOS2Endothelial cellsGenePulmonaryInhibitorsDeficiencyReactive oxygenMetabolismEnzymeMediatesSignaling pathwayExpressionSprague-DawleyVascularSerumApoptosisSuppressionMethylationAcuteProteinsProductionCellsRatsMediatorsEndotoxemiaNitriteDiabeticSynthesisDiabetes mellitusProteinInfectionCatalyticConclusionsRoleTetrahydrobiopterinInhibitorPathwaysStabilityAminoMeSHInterferonInnate
Inhibition4
  • Cao, W, Bao, C & Lowenstein, CJ 2003, ' Inducible nitric oxide synthase expression inhibition by adenovirus E1A ', Proceedings of the National Academy of Sciences of the United States of America , vol. 100, no. 13, pp. 7773-7778. (elsevier.com)
  • Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury. (elsevier.com)
  • We report here the inhibition of IFN-γ-induced NO production in RAW264.7 macrophages infected with wild-type Salmonella. (mssm.edu)
  • Chen H, Birnbaum Y , Ye R, Yang HC, Bajaj M , Ye Y. SGLT2 Inhibition by Dapagliflozin Attenuates Diabetic Ketoacidosis in Mice with Type-1 Diabetes. (viictr.org)
Macrophages6
  • of inducible nitric oxide synthase (iNOS) and of cyclooxygenase 2 in mouse macrophages. (dundee.ac.uk)
  • The high potency of TP analogues in inducing the phase 2 response and blocking inflammation depends on the presence of activated Michael reaction (enone) functions at critical positions in rings A and C. The most potent TP doubles NAD(P)H-quinone oxidoreductase in murine hepatoma cells at 0.28 nM and has an IC50 for suppression of iNOS induction in primary mouse macrophages of 0.0035 nM. (dundee.ac.uk)
  • Activation of macrophages by interferon gamma (IFN-γ) and the subsequent production of nitric oxide (NO) are critical for the host defence against Salmonella enterica serovar Typhimurium infection. (mssm.edu)
  • We previously showed that DHA inhibits activation of the gene for inducible nitric oxide synthase (iNOS) in murine macrophages stimulated in vitro with interferon γ (IFNγ) plus lipopolysaccharide (LPS). (elsevier.com)
  • An assay system was developed which separated the stimulation of macrophages by IFNγ plus LPS, and the actual production of nitric oxide (NO). It was found that macrophages do not produce NO until they have been stimulated by IFNγ plus LPS for a period of 10 h. (elsevier.com)
  • Data are presented indicating that in vitro or in vivo exposure to selected occupational dusts, i.e., crystalline silica, organic dust contaminated with endotoxin, or asbestos , results in upregulation of inducible ntric oxide synthase (iNOS) and the production of NO by alveolar macrophages and pulmonary epitelial cells. (cdc.gov)
Mice9
  • Vehicle (saline) or an adenovirus carrying the gene for either hTK (Ad.hTK) or luciferase (Ad.Luc) was injected into left adductor muscles of streptozotocin-induced type 1 diabetic mice 2 weeks before operative occlusion of the ipsilateral femoral artery. (bris.ac.uk)
  • We found that limb perfusion recovery of saline-injected type 1 diabetic mice is delayed because of insufficient reparative neovascularization and excessive activation of endothelial cell apoptosis. (bris.ac.uk)
  • Both ob/ob and db/db mice model phase I and phase II diabetes, but only on the C57BLKS/J background, do they progress to phase III. (jax.org)
  • NONcNZO10/LtJ mice are a recombinant congenic line that was bred by JAX Professor Dr. Ed Leiter to specifically combine six diabetes susceptibility alleles derived from the obesity and diabetes-prone strain NZO/LtJ with two from diabetes-resistant and normally non-obese NON/ShiLtJ. (jax.org)
  • In iNOS knockout mice, the organ load of the nirC knockout strain was similar to that of the wild-type strain, indicating that the mutant is exclusively sensitive to the host nitrosative stress. (mssm.edu)
  • Diesel exhaust particle-induced oxidant injury and cellular responses in wild type and inducible nitric oxide synthase-deficient (iNOS KO) mice: roles of particle core and adsorbed organics. (cdc.gov)
  • Methods: Male inbred C57BL6/J mice 8-week to 12-week-old as wild type and iNOS gene knock out (iNOS-/-), weighing 20 g to 35 g, were used. (fujita-hu.ac.jp)
  • Inflammation up-regulates P2Y 2 as well as P2Y 6 receptor expression in the mucosa of the colon of colitic mice. (aai.org)
  • Background Prokineticin 2 (PK2) manifestation is upregulated in mice with collagen-induced joint disease (CIA), an pet model of arthritis rheumatoid. (exposed-skin-care.net)
ENOS7
  • IMSEAR at SEARO: Endothelial nitric oxide synthase (eNOS) VNTR as a probable marker in type 2 diabetes mellitus. (who.int)
  • Umbilical vessels lack innervations, thus endothelial cells must play a role in the control of blood flow.The aim of this study was to investigate in human umbilical cord the expression of five peptides that could beinvolved in the regulation of vascular tone: Orphanin FQ, Oxytocin, Atrial Natriuretic Peptide (ANP), endothelialNitric Oxide Synthase (eNOS) and inducible Nitric Oxide Synthase (iNOS). (unipa.it)
  • Cell Biology - Signal Transduction: Gandhi T. K. Boopathy, Madhura Kulkarni, Sze Yuan Ho, Adrian Boey, Edmond Wei Min Chua, Veluchamy A. Barathi, Tom J. Carney, Xiaomeng Wang, and Wanjin Hong Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis J. Biol. (a-star.edu.sg)
  • Interestingly, we also found that Cavin-2 regulates the production of nitric oxide (NO) in endothelial cells by controlling the stability and activity of the endothelial nitric-oxide synthase (eNOS) and that Cavin-2 knockdown cells produce much less NO than WT cells. (a-star.edu.sg)
  • Taken together, our results indicate that in addition to its function in caveolae biogenesis, Cavin-2 plays a critical role in endothelial cell maintenance and function by regulating eNOS activity. (a-star.edu.sg)
  • The main substrate for NO synthesis is the amino acid L-arginine, which is processed by NO synthases (NOS) from three subtypes for its production: neuronal (nNOS), endothelial (eNOS) and inducible (iNOS). (bvsalud.org)
  • After 48 h, the expression levels of endothelial nitric oxide synthase (eNOS) and phosphorylated eNOS (p-eNOS) were detected by Western blot ( n =3). (magtech.com.cn)
Inflammation7
  • Liver fat and serum transaminase increased after 2 weeks, but evidence of liver cell injury and inflammation (ASH) occurred after 8 weeks. (nih.gov)
  • Inducible nitric oxide synthase, coded by NOS2, is involved in inflammation, and particulate exposure increases the gene's expression through methylation of CpG sites in the 5' region. (cdc.gov)
  • Conclusions: Inflammation mediated by inducible nitric oxide synthase may possibly contribute to the association between welding fume and parkinsonism, but requires verification in a longitudinal study. (cdc.gov)
  • Thus, in addition to blocking inflammation and promoting differentiation, these TP exhibit another very important protective property: the induction of the phase 2 response. (dundee.ac.uk)
  • We show for the first time that P2Y 6 , as well as P2Y 2 , expression is increased by the stress associated with intestinal inflammation. (aai.org)
  • Nitric oxide production is assocated temporarilly and anatomically with pulmonary damange, inflammation, and disease progression in response to occupational dusts. (cdc.gov)
  • [2] Other side effects may include anaphylaxis , stomach inflammation , and hyperactivity. (mdwiki.org)
NOS22
  • We show that the adenovirus E1A protein inhibits NO production by decreasing expression of the inducible NO synthase (NOS2). (elsevier.com)
  • Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes. (cdc.gov)
Endothelial cells2
  • Using endothelial cells, we show that Cavin-2 is required for in vitro angiogenesis and also for endothelial cell proliferation, migration, and invasion. (a-star.edu.sg)
  • This study aimed to investigate the inhibitory effect of blueberry anthocyanin (BBA) on Angiotensin II (Ang II)-induced apoptosis of human umbilical vein endothelial cells (HUVECs), and its regulation mechanisms involving Bax and Caspase 3. (medscimonit.com)
Gene3
  • Inducible nitric oxide synthase gene methylation and parkinsonism in manganese -exposed welders. (cdc.gov)
  • Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with hypertension, alcohol intake, and cigarette smoking. (cocites.com)
  • Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use. (cocites.com)
Pulmonary2
  • Bacterial lipopolysaccharide (LPS) (15 mg/kg intraperitoneally [IP]) significantly increased pulmonary iNOS activity and serum levels of nitrite/nitrate (NO 2 /NO 3 ). (utmb.edu)
  • Enhancement of nitric oxide production by pulmonary cells following silica exposure. (cdc.gov)
Inhibitors1
  • 2004 Dec 6;14(23):5907-11.Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. (idrblab.net)
Deficiency4
  • One of the main causes for erectile dysfunction (ED) is related to nitric oxide (NO) deficiency in human body. (bvsalud.org)
  • Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling intetrahydrobiopterin deficiency. (medscape.com)
  • Sapropterin is used in tetrahydrobiopterin deficiency caused by GTP cyclohydrolase I (GTPCH) deficiency, or 6-pyruvoyltetrahydropterin synthase (PTPS) deficiency. (mdwiki.org)
  • [4] A dose of 2 to 5 mg/kg per day may be used in tetrahydrobiopterin deficiency. (mdwiki.org)
Reactive oxygen2
  • An epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide and reactive oxygen species in mitochondria with an ancillary missive concerning the origins of apoptosis. (cdc.gov)
  • One of the major sources of reactive oxygen species (ROS) in neurodegeneration is NADPH oxidase, a multimeric enzyme that generates both superoxide O 2 − (O 2 and H 2 O 2 [ 8 ]. (springer.com)
Metabolism1
  • 2. Wolf , G.: Metabolism of excitatory amino acid transmitters and pathogenetic implica-tions. (geraldwolfmd.de)
Enzyme2
  • 2-5 Scientists have been familiar with this enzyme for some time due to its role in occurrence of arthritis, asthma and Crohn's disease, which is why the pharmaceutical industry aims to develop a safe drug to alleviate the effect of 5-lipoxygenase. (our-arthritis.com)
  • 1, 2, 3 The performance of the reverse transcription (RT) response may be suffering from the enzyme, primers, nucleotides, and RNA secondary framework. (irjs.info)
Mediates2
  • Hydrogen peroxide mediates the apoptotic effect of cisplatin by downregulating bcl-2 through ubiquitin-proteasomal degradation. (cdc.gov)
  • Tion and epidemiology of ed may be made available some of you after the sexually a loss of endothelial nitric-oxide synthase mediates penile erection. (psm.edu)
Signaling pathway1
  • Moreover, like previously identified phase 2 inducers, the TP analogues use the antioxidant response element-Nrf2-Keap1 signaling pathway. (dundee.ac.uk)
Expression8
  • By contrast, prophylactic Ad.hTK renewed the ability to mount an appropriate neovascularization response to ischemia, suppressed apoptosis, and upregulated endothelial nitric oxide synthase expression. (bris.ac.uk)
  • This enhanced SPI2 repression in the nirC knockout led to a higher level of STAT-1 phosphorylation and inducible nitric oxide synthase (iNOS) expression than seen with the wild-type strain. (mssm.edu)
  • We noted a high level of Cavin-2 expression in the neovascular tufts in the mouse model of oxygen-induced retinopathy, suggesting a role for Cavin-2 in pathogenic angiogenesis. (a-star.edu.sg)
  • Western blot analysis was performed to detect the expression of Bax and Caspase 3 in these 2 groups. (medscimonit.com)
  • Analysis of Mononuclear Cell Nitric Oxide Synthase Type 2 Antigen Expression / Jocelyn R. Saunders, Mary A. Misukonis, J. Brice Weinberg -- Pt. (who.int)
  • We have confirmed the increased expression of P2Y 6 by challenging intestinal epithelial cell-6 and Caco-2/15 cells with TNF-α and IFN-γ and showing that stimulation of epithelial cells by UDP results in an increased expression and release of CXCL8 by an ERK1/2-dependent mechanism. (aai.org)
  • To fulfill those expectations, ESCs have to be directed at high efficiency to disease relevant cell types, either by the application of extracellular signals or direct programming by forced expression of transcription factors. (nyu.edu)
  • HDFA expression profiles of two subclones differing in the integration status of HPV INCB018424 biological activity (integrated or mixed episomal/integrated) as a model system to test our validation approach. (irjs.info)
Sprague-Dawley1
  • Neuropathic pain was induced by intraperitoneal injection of paclitaxel (2 mg/kg) on four alternate days (days 0, 2, 4, and 6) in male Sprague-Dawley rats. (asahq.org)
Vascular2
  • Overproduction of nitric oxide (NO) by iNOS contributes significantly to the vascular failure and end-organ damage in endotoxemia. (utmb.edu)
  • later, vascular injury was noted during the Each sample was divided into 2 × 5 mL por- annual medical examination. (who.int)
Serum4
  • All three treatments significantly prevented the increase in both lung iNOS activity and serum NO 2 /NO 3 associated with endotoxemia. (utmb.edu)
  • Our findings suggest that susceptibility to recurrent lymphocytic meningitis might be caused by low serum IgG subclass 2 immunodeficiency. (cdc.gov)
  • Previous research has reported an association of low serum IgG subclass 1 (IgG1) and IgG subclass 3 (IgG3) levels with increased frequency of RBLM ( 2 ). (cdc.gov)
  • We report an unusual case of serum IgG subclass 2 immunodeficiency in a patient with 8 lifetime episodes of RBLM. (cdc.gov)
Apoptosis3
  • We investigated how hypertonic saline resuscitation affected the induction of CD4CD25 regulatory T cells and γδT cells, and their apoptosis after hemorrhagic shock and resuscitation, and its relationship to inducible nitric oxide synthase (iNOS) (nitric oxide production). (fujita-hu.ac.jp)
  • Then, HUVECs were randomly divided into the Ang II group (10-6 mol/L Ang II) and Ang II + BBA group (10-6 mol/L Ang II and 20 μg/ml BBA), and the apoptosis rate was detected by flow cytometry. (medscimonit.com)
  • BBA increased cell viability and reduced apoptosis rate of HUVECs induced by Ang II through Bax- and Caspase 3-dependent pathways. (medscimonit.com)
Suppression2
  • Female rats express heroin-induced and -conditioned suppression of peripheral nitric oxide production in response to endotoxin challenge. (musc.edu)
  • Thus, induction of the phase 2 response and suppression of the iNOS induction was abrogated in nrf2? (dundee.ac.uk)
Methylation1
  • One common type of modification is methylation of lysine or arginine residues. (blogspot.com)
Acute1
  • The patients treated (E)-2-Decenoic acid IC50 in our department had acute complications that had the potential for significant morbidity. (healthcarecoremeasures.com)
Proteins1
  • Adjustments in the manifestation of transcription elements like Zinc finger E-box-binding homeobox 1/2 (ZEB1/2), Zinc finger proteins SNAIL1 (SNAIL), Twist-related proteins 1 (TWIST) or vimentin (VIM) might become prognostic factors along the way of carcinogenesis [16]. (cancerhugs.com)
Production4
  • Time courses for development of gut hyperpermeability, nitric oxide production, oxidative injury to the gut, endotoxemia, and liver injury were assessed in rats during 10 weeks of daily alcohol gavage. (nih.gov)
  • We provide evidence that both pre-treating and post-treating the cells with Withaferin A attenuate astrocytic NF-B activity as well as the consequent production of TNFα, COX-2, and iNOS induced by stimulation of the LPS/TLR4 pathway. (elsevier.com)
  • Decreased nitric oxide production in primary open-angle glaucoma. (cocites.com)
  • It is a cofactor of the three aromatic amino acid hydroxylase enzymes, [17] used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin , dopamine , norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide syntheses. (mdwiki.org)
Cells18
  • Here, we show that these analogues are also extremely potent inducers of the phase 2 response [e.g., elevation of NAD(P)H-quinone oxidoreductase and heme oxygenase 1], which is a major protector of cells against oxidative and electrophile stress. (dundee.ac.uk)
  • Full-term human umbilical cord contains three blood vessels: two arteries coiled around a vein andsurrounded by Wharton's jelly, a mucous tissue with few mesenchymal stromal cells and abundant extracellularmatrix. (unipa.it)
  • Conclusion: γδ T cells increased earlier at 24 hours, whereas CD4CD25 regulatory T cells increased later at 48 hours in spleen of wild type. (fujita-hu.ac.jp)
  • CD4CD25 regulatory T cells at 48 hours without iNOS decreased compared with those of wild type. (fujita-hu.ac.jp)
  • Type I interferons produced by dendritic cells promote their phenotypic and functional activation , Blood , vol. 99 , issue. (archives-ouvertes.fr)
  • Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon , Nature Immunology , vol. 4 , issue. (archives-ouvertes.fr)
  • P. Marrack, J. Kappler, and T. Mitchell , Type I Interferons Keep Activated T Cells Alive , The Journal of Experimental Medicine , vol. 29 , issue. (archives-ouvertes.fr)
  • Cutting Edge: CD8 T Cells Specific for Lymphocytic Choriomeningitis Virus Require Type I IFN Receptor for Clonal Expansion , The Journal of Immunology , vol. 176 , issue. (archives-ouvertes.fr)
  • G. Kolumam, S. Thomas, L. Thompson, J. Sprent, and K. Murali-krishna , Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection , The Journal of Experimental Medicine , vol. 4 , issue. (archives-ouvertes.fr)
  • Early type?I interferon-mediated signals on B cells specifically enhance antiviral humoral responses , European Journal of Immunology , vol. 183 , issue. (archives-ouvertes.fr)
  • Shear stress-triggered nitric oxide release from Schlemm's canal cells. (cocites.com)
  • In vitro, we demonstrated that UDP could be released by Caco-2/15 cells. (aai.org)
  • These results demonstrate a primary role for B cells and/or (auto)antibodies in initiating several types of autoimmune-mediated tissue destruction. (silverchair.com)
  • This technique is based on Melcher's 10 (1970) observation that the type of tissue formed in a given area depends on the type of cells populating that area. (bvsalud.org)
  • Today's study evaluates the result of ZEA within the cell migration and invasiveness from the prostate adenocarcinoma cell series Computer3, at two doses thought to possess a stimulatory influence on PCa cells. (cancerhugs.com)
  • buy 96829-58-2 buy 96829-58-2 Our present results show that while both concentrations triggered a rise in cell invasion, a larger degree was noticed for cells treated with 0.001 nM ZEA than control cells (*** 0.001) and nonsignificant for 0.1 nM ZEA ( 0.05) (Figure 1B,C). Open up in another window Open up in another window Number 1 ZEA induces Personal computer3 cell invasion reliant on ER. (cancerhugs.com)
  • Materials and Methods Cell Culture and RNA Extraction Two subclones of W12 cervical epithelial cells with HPV16 in differing physical states were a gift from Dr. Paul Lambert (University of Wisconsin, Madison, WI). (irjs.info)
  • In contrast, STAT3 was not required for GM-CSF induced DC differentiation as both wild type and STAT3 null bone marrow cells gave rise to comparable number of DCs. (researchreportone.com)
Rats1
  • 2. Rats were treated with bosentan or vehicle (5% gum arabic) for 7 days by gavage. (shengsci.com)
Mediators1
  • Here we demonstrate that the activation of astrocytic TLR4 by bacterial lipopolysaccharide (LPS) challenge can promote nuclear factor B (NF-B)-dependent induction of pro-inflammatory and stress response mediators, particularly Tumor Necrosis Factor α (TNFα), cyclooxygenase 2 (COX-2), and inducible nitric oxide synthase (iNOS). (elsevier.com)
Endotoxemia2
  • Gut leakiness, intestinal oxidative injury, and endotoxemia occurred in weeks 2-4 and progressed thereafter. (nih.gov)
  • The inducible isoform of nitric oxide synthase (iNOS) is expressed in various organs, including the lung, during systemic endotoxemia. (utmb.edu)
Nitrite2
  • Under acidified nitrite stress, a twofold more pronounced NO-mediated repression of SPI2 was observed in the nirC knockout strain compared to the wild-type. (mssm.edu)
  • Levels of nitrite (NO 2 − ), a metabolite of nitric oxide ( · NO and inducible nitric oxide synthase (iNOS) are higher in the central nervous system of human PD cases and in animal models of PD [ 6 ]. (springer.com)
Diabetic2
  • Two diabetic strains whose diabetes and obesity develop from combinations of diabetes-susceptibility alleles are now available, and are becoming more widely used: NONcNZO10/LtJ ( 004456 ) and TALLYHO/JngJ ( 005314 ). (jax.org)
  • Nitric oxide: ocular blood flow, glaucoma, and diabetic retinopathy. (cocites.com)
Synthesis1
  • Nitric-oxide synthase (NOS) catalyzes nitric oxide (NO) synthesis via a two-step process: L-arginine (L-Arg) → N-hydroxy-Larginine → citrulline + NO. In the active site the heme is coordinated by a thiolate ligand, which accepts a H-bond from a nearby tryptophan residue, Trp-188. (elsevier.com)
Diabetes mellitus4
  • Generally, in diabetes there are numerous genes involved, each being a small contributor in type 2 diabetes mellitus (T2DM) manifestation. (who.int)
  • Metformin, an insulin-sensitizer, may correct several physiologic abnormalities owing to insulin resistance in patients with type 2 diabetes mellitus (DM). (biomedcentral.com)
  • Insulin resistance contributes greatly to development of cardiovascular disease in patient with metabolic syndrome and type 2 diabetes mellitus (DM). (biomedcentral.com)
  • Utilizing a nationwide database, we conducted this nonrandomized, pair-matched cohort study to investigate the relationship between metformin therapy and the subsequent development of deep venous thrombosis among patients with type 2 diabetes mellitus. (biomedcentral.com)
Protein3
  • Here, focusing on potential candidate genes for angiogenesis, we performed a morpholino-based genetic screen in zebrafish and identified Cavin-2, a membrane-bound phosphatidylserine-binding protein and critical organizer of caveolae (small microdomains in the plasma membrane), as a regulator of angiogenesis. (a-star.edu.sg)
  • Neuroinflammatory markers, such as ionized calcium binding adaptor molecule 1 (Iba-1), glial fibrillary acidic protein (GFAP), gp91phox and inducible nitric oxide synthase (iNOS), were measured in the nigrostriatal system. (springer.com)
  • But the researchers noticed that, according to the docking results, fragments such as compound 4 could assume two different binding modes: in one, the carboxylate and phenol interacted with the iron atom, while in the other the carboxylate interacted with lysine and tyrosine residues in the protein. (blogspot.com)
Infection4
  • Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling , Science , vol. 69 , issue. (archives-ouvertes.fr)
  • Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection , Science , vol. 22 , issue. (archives-ouvertes.fr)
  • I Assessing Risk of Infection and Severity of Disease -- Ch.1 Vector Incrimination and Entomological -- Ch.2 Epidemiological Measures of Risk of Malaria / J. Kevin Baird, Michael J. Bangs, Jason D. Maguire 13 Pt. (who.int)
  • Despite our growing understanding of the and 500 000 dengue haemorrhagic fever (DHF) various facets of dengue virus infection, the cases occurring annually[1,2]. (who.int)
Catalytic1
  • At Scripps, Crane studied metalloenzymes and applied structural biology techniques to trying to understand the catalytic mechanisms of two types of redox enzymes, sulfite reductases and nitric oxide synthases. (sbgrid.org)
Conclusions1
Role6
  • A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. (musc.edu)
  • Role of nitric oxide in the control of ocular blood flow. (cocites.com)
  • Nitric oxide: a review of its role in retinal function and disease. (cocites.com)
  • Role of nitric oxide in murine conventional outflow physiology. (cocites.com)
  • Role of nitric oxide in the progression of pneumoconiosis. (cdc.gov)
  • It is possible to find different techniques using physical barriers 2-7 and the characteristics of the biomaterial and the design of the membrane used in guided tissue regeneration play an important role in obtaining good results 8 . (bvsalud.org)
Tetrahydrobiopterin1
  • Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase. (medscape.com)
Inhibitor1
  • Asymmetric Dimethylarginine (ADMA) acts as an endogenous inhibitor of the three subtypes of NOS and is metabolized by enzymes dimethylarginine dimethylaminohydrolase types 1 and 2 (DDAH1 and DDAH2). (bvsalud.org)
Pathways1
  • Nitric oxide/guanylate cyclase pathways and flow in anterior segment perfusion. (cocites.com)
Stability1
  • The capacity and stability of nickel cobalt oxide (NCO) cathode are unsatisfactory because of its semiconductor character. (bvsalud.org)
Amino1
  • GLU and its biochemical "cousin," aspartic acid or aspartate (ASP), are the two most plentiful amino acids in the brain (5). (antiaging-nutrition.com)
MeSH2
  • Nitric Oxide Synthase Type II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
  • Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. (viictr.org)
Interferon3
  • L. Platanias , Mechanisms of type-I- and type-II-interferon-mediated signalling , Nature Reviews Immunology , vol. 132 , issue. (archives-ouvertes.fr)
  • G. Trinchieri , Type I interferon: friend or foe? (archives-ouvertes.fr)
  • L. Ivashkiv and L. Donlin , Regulation of type I interferon responses , Nature Reviews Immunology , vol. 7 , issue. (archives-ouvertes.fr)
Innate2
  • Nitric oxide (NO) is an antiviral effector of the innate immune system. (elsevier.com)
  • Figure 2: Leptin effects on innate and adaptive immunity. (nature.com)
Leptin in the interplay of inflammation, metabolism and immune system disorders | Nature Reviews Rheumatology
Leptin in the interplay of inflammation, metabolism and immune system disorders | Nature Reviews Rheumatology (nature.com)
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Increased nitric oxide levels and iNOS over-expression in oral squamous cell carcinoma - Fingerprint - NYU Scholars
Increased nitric oxide levels and iNOS over-expression in oral squamous cell carcinoma - Fingerprint - NYU Scholars (nyuscholars.nyu.edu)
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MeSH Browser
MeSH Browser (meshb.nlm.nih.gov)
IJMS | Free Full-Text | Protective Effects of Melatonin on the Skin: Future Perspectives
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