A species of HENIPAVIRUS, closely related to HENDRA VIRUS, which emerged in Peninsular Malaysia in 1998. It causes a severe febrile VIRAL ENCEPHALITIS in humans and also encephalitis and RESPIRATORY TRACT INFECTIONS in pigs. Fruit bats (PTEROPUS) are the natural host.
Infections with viruses of the genus HENIPAVIRUS, family PARAMYXOVIRIDAE.
A subfamily of PARAMYXOVIRIDAE. Genera include RUBULAVIRUS; RESPIROVIRUS; MORBILLIVIRUS; HENIPAVIRUS; and AVULAVIRUS.
A species of HENIPAVIRUS first identified in Australia in 1994 in HORSES and transmitted to humans. The natural host appears to be fruit bats (PTEROPUS).
A genus in the subfamily PARAMYXOVIRINAE, family PARAMYXOVIRIDAE. It contains species that infect and cause potentially fatal disease in a number of host species, including humans.
Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.
Order of mammals whose members are adapted for flight. It includes bats, flying foxes, and fruit bats.
A parliamentary democracy with a constitutional monarch in southeast Asia, consisting of 11 states (West Malaysia) on the Malay Peninsula and two states (East Malaysia) on the island of BORNEO. It is also called the Federation of Malaysia. Its capital is Kuala Lumpur. Before 1963 it was the Union of Malaya. It reorganized in 1948 as the Federation of Malaya, becoming independent from British Malaya in 1957 and becoming Malaysia in 1963 as a federation of Malaya, Sabah, Sarawak, and Singapore (which seceded in 1965). The form Malay- probably derives from the Tamil malay, mountain, with reference to its geography. (From Webster's New Geographical Dictionary, 1988, p715 & Room, Brewer's Dictionary of Names, 1992, p329)
Infections with viruses of the family PARAMYXOVIRIDAE. This includes MORBILLIVIRUS INFECTIONS; RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS.
A transmembrane domain containing ephrin that binds with high affinity to EPHB1 RECEPTOR; EPHB3 RECEPTOR; and EPHB4 RECEPTOR. Expression of ephrin-B2 occurs in a variety of adult tissues. During embryogenesis, high levels of ephrin-B2 is seen in the PROSENCEPHALON; RHOMBENCEPHALON; developing SOMITES; LIMB BUD; and bronchial arches.
The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract, and intestinal tract. Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
Inanimate objects that carry pathogenic microorganisms and thus can serve as the source of infection. Microorganisms typically survive on fomites for minutes or hours. Common fomites include CLOTHING, tissue paper, hairbrushes, and COOKING AND EATING UTENSILS.
A transmembrane domain containing ephrin. Although originally found to be specific for the EPHB3 RECEPTOR it has since been shown to bind a variety of EPH FAMILY RECEPTORS. During embryogenesis ephrin-B3 is expressed at high levels in the ventral neural tube. In adult tissues, it is found primarily in the BRAIN and HEART.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
Viruses whose genetic material is RNA.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.
The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.
Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Diseases of non-human animals that may be transmitted to HUMANS or may be transmitted from humans to non-human animals.
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
Proteins found in any species of virus.
Diseases of domestic swine and of the wild boar of the genus Sus.
Process of growing viruses in live animals, plants, or cultured cells.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.
A family of spherical viruses, of the order MONONEGAVIRALES, somewhat larger than the orthomyxoviruses, and containing single-stranded RNA. Subfamilies include PARAMYXOVIRINAE and PNEUMOVIRINAE.
The act or ceremony of putting a corpse into the ground or a vault, or into the sea; or the inurnment of CREMAINS.
A general term for diseases produced by viruses.
Groups set up to advise governmental bodies, societies, or other institutions on policy. (Bioethics Thesaurus)

A golden hamster model for human acute Nipah virus infection. (1/171)

A predominantly pig-to-human zoonotic infection caused by the novel Nipah virus emerged recently to cause severe morbidity and mortality in both animals and man. Human autopsy studies showed the pathogenesis to be related to systemic vasculitis that led to widespread thrombotic occlusion and microinfarction in most major organs especially in the central nervous system. There was also evidence of extravascular parenchymal infection, particularly near damaged vessels (Wong KT, Shieh WJ, Kumar S, Norain K, Abdullah W, Guarner J, Goldsmith CS, Chua KB, Lam SK, Tan CT, Goh KJ, Chong HT, Jusoh R, Rollin PE, Ksiazek TG, Zaki SR, Nipah Virus Pathology Working Group: Nipah virus infection: Pathology and pathogenesis of an emerging paramyxoviral zoonosis. Am J Pathol 2002, 161:2153-2167). We describe here a golden hamster (Mesocricetus auratus) model that appears to reproduce the pathology and pathogenesis of acute human Nipah infection. Hamsters infected by intranasal or intraperitoneal routes died within 9 to 29 days or 5 to 9 days, respectively. Pathological lesions were most severe and extensive in the hamster brain. Vasculitis, thrombosis, and more rarely, multinucleated endothelial syncytia, were found in blood vessels of multiple organs. Viral antigen and RNA were localized in both vascular and extravascular tissues including neurons, lung, kidney, and spleen, as demonstrated by immunohistochemistry and in situ hybridization, respectively. Paramyxoviral-type nucleocapsids were identified in neurons and in vessel walls. At the terminal stage of infection, virus and/or viral RNA could be recovered from most solid organs and urine, but not from serum. The golden hamster is proposed as a suitable model for further studies including pathogenesis studies, anti-viral drug testing, and vaccine development against acute Nipah infection.  (+info)

Nipah virus: vaccination and passive protection studies in a hamster model. (2/171)

Nipah virus, a member of the paramyxovirus family, was first isolated and identified in 1999 when the virus crossed the species barrier from fruit bats to pigs and then infected humans, inducing an encephalitis with up to 40% mortality. At present there is no prophylaxis for Nipah virus. We investigated the possibility of vaccination and passive transfer of antibodies as interventions against this disease. We show that both of the Nipah virus glycoproteins (G and F) when expressed as vaccinia virus recombinants induced an immune response in hamsters which protected against a lethal challenge by Nipah virus. Similarly, passive transfer of antibody induced by either of the glycoproteins protected the animals. In both the active and passive immunization studies, however, the challenge virus was capable of hyperimmunizing the vaccinated animals, suggesting that although the virus replicates under these conditions, the immune system can eventually control the infection.  (+info)

Nipah virus conforms to the rule of six in a minigenome replication assay. (3/171)

To study the replication of Nipah virus (NiV), a minigenome replication assay that does not require the use of infectious virus was developed. The minigenome was constructed to encode a NiV vRNA analogue containing the gene for chloramphenicol acetyltransferase (CAT) under the control of putative NiV transcription motifs and flanked by the NiV genomic termini. CAT protein was detected only when plasmids encoding the NiV minigenome, nucleocapsid protein (N), phosphoprotein (P) and polymerase protein (L) were transfected into CV1 cells. To determine whether NiV conforms to the rule of six, a series of plasmids encoding minigenomes that differed in length by a single nucleotide was tested in the replication assay. CAT production was detected only with the minigenome whose length was an even multiple of six. The replication assay was also used to show that the N, P and L proteins of NiV recognize cis-acting sequences in the genomic termini of Hendra virus (HeV) but not measles virus. While these results suggest that NiV uses a replication strategy that is similar to those of other paramyxoviruses, they also support the inclusion of NiV and HeV in a separate genus within the subfamily Paramyxovirinae.  (+info)

Identification of the nuclear export signal and STAT-binding domains of the Nipah virus V protein reveals mechanisms underlying interferon evasion. (4/171)

The V proteins of Nipah virus and Hendra virus have been demonstrated to bind to cellular STAT1 and STAT2 proteins to form high-molecular-weight complexes that inhibit interferon (IFN)-induced antiviral transcription by preventing STAT nuclear accumulation. Analysis of the Nipah virus V protein has revealed a region between amino acids 174 and 192 that functions as a CRM1-dependent nuclear export signal (NES). This peptide is sufficient to complement an export-defective human immunodeficiency virus Rev protein, and deletion and substitution mutagenesis revealed that this peptide is necessary for both V protein shuttling and cytoplasmic retention of STAT1 and STAT2 proteins. However, the NES is not required for V-dependent IFN signaling inhibition. IFN signaling is blocked primarily by interaction between Nipah virus V residues 100 to 160 and STAT1 residues 509 to 712. Interaction with STAT2 requires a larger Nipah virus V segment between amino acids 100 and 300, but deletion of residues 230 to 237 greatly reduced STAT2 coprecipitation. Further, V protein interactions with cellular STAT1 is a prerequisite for STAT2 binding, and sequential immunoprecipitations demonstrate that V, STAT1, and STAT2 can form a tripartite complex. These findings characterize essential regions for Henipavirus V proteins that represent potential targets for therapeutic intervention.  (+info)

Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively. (5/171)

In previous reports it was demonstrated that the Nipah virus V and W proteins have interferon (IFN) antagonist activity due to their ability to block signaling from the IFN-alpha/beta receptor (J. J. Rodriguez, J. P. Parisien, and C. M. Horvath, J. Virol. 76:11476-11483, 2002; M. S. Park et al., J. Virol. 77:1501-1511, 2003). The V, W, and P proteins are all encoded by the same viral gene and share an identical 407-amino-acid N-terminal region but have distinct C-terminal sequences. We now show that the P protein also has anti-IFN function, confirming that the common N-terminal domain is responsible for the antagonist activity. Truncation of this N-terminal domain revealed that amino acids 50 to 150 retain the ability to block IFN and to bind STAT1, a key component of the IFN signaling pathway. Subcellular localization studies demonstrate that the V and P proteins are predominantly cytoplasmic whereas the W protein is localized to the nucleus. In all cases, STAT1 colocalizes with the corresponding Nipah virus protein. These interactions are sufficient to inhibit STAT1 activation, as demonstrated by the lack of STAT1 phosphorylation on tyrosine 701 in IFN-stimulated cells expressing P, V, or W. Therefore, despite their common STAT1-binding domain, the Nipah virus V and P proteins act by retaining STAT1 in the cytoplasm while the W protein sequesters STAT1 in the nucleus, creating both a cytoplasmic and a nuclear block for STAT1. We also show that the IFN antagonist activity of the P protein is not as strong as that of V or W, perhaps explaining why Nipah virus has evolved to express these two edited products.  (+info)

Influence of N-glycans on processing and biological activity of the nipah virus fusion protein. (6/171)

Nipah virus (NiV), a new member of the Paramyxoviridae, codes for a fusion (F) protein with five potential N-glycosylation sites. Because glycans are known to be important structural components affecting the conformation and function of viral glycoproteins, we analyzed the effect of the deletion of N-linked oligosaccharides on cell surface transport, proteolytic cleavage, and the biological activity of the NiV F protein. Each of the five potential glycosylation sites was removed either individually or in combination, revealing that four sites are actually utilized (g2 and g3 in the F(2) subunit and g4 and g5 in the F(1) subunit). While the removal of g2 and/or g3 had no or little effect on cleavage, surface transport, and fusion activity, the elimination of g4 or g5 reduced the surface expression by more than 80%. Similar to a mutant lacking all N-glycans, g4 deletion mutants in which the potential glycosylation site was destroyed by introducing a glycine residue were neither cleaved nor transported to the cell surface and consequently were not able to mediate cell-to-cell fusion. This finding indicates that in the absence of g4, the amino acid sequence around position 414 is important for folding and transport.  (+info)

Ubiquitous activation of the Nipah virus fusion protein does not require a basic amino acid at the cleavage site. (7/171)

Nipah virus (NiV), a highly pathogenic paramyxovirus, causes a systemic infection in vivo and is able to replicate in cultured cells of many species and organs. Such pantropic paramyxoviruses generally encode fusion (F) proteins with multibasic cleavage sites activated by furin or other ubiquitous intracellular host cell proteases. In contrast, NiV has an F protein with a single arginine (R109) at the cleavage site, as is the case with paramyxoviruses that are activated by trypsin-like proteases only present in specific cells or tissues and therefore only cause localized infections. Unlike these viruses, cleavage of the NiV F protein is ubiquitous and does not require the addition of exogenous proteases in cell culture. To determine the importance of the amino acid sequence at the NiV F protein cleavage site for ubiquitous activation, we generated NiV F proteins with mutations around R109. Surprisingly, neither the exchange of amino acids upstream of R109 nor replacement of the basic residue itself interfered with F cleavage. Thus, R109 is not essential for F cleavage and activation. Our data demonstrate that NiV F-protein activation depends on a novel type of proteolytic cleavage that has not yet been described for any other paramyxovirus F protein. NiV F activation is mediated by a ubiquitous protease that requires neither a monobasic nor a multibasic cleavage site and therefore differs from the furin- or trypsin-like proteases known to activate other ortho- and paramyxovirus fusion proteins.  (+info)

Reactivity of anti-Nipah virus monoclonal antibodies to formalin-fixed, paraffin-embedded lung tissues from experimental Nipah and Hendra virus infections. (8/171)

The immunohistochemical reactivity of seven clones of mouse monoclonal antibodies raised to Nipah virus antigens were investigated using formalin-fixed, paraffin embedded porcine and equine lung tissues from experimental Nipah and Hendra virus infection, respectively. Either microwave irradiation or enzymatic digestion effectively unmasked the viral antigens in formalin-fixed, paraffin-embedded tissue sections. Four clones showed positive reaction to both Nipah virus-infected porcine lung tissue and Hendra virus-infected equine lung tissue. Two clones (11F6 and 13A5) reacted with Nipah virus-infected porcine lung tissue, but not with Hendra virus-infected equine lung tissue. These Nipah virus-specific monoclonal antibodies may therefore be useful for immunohistological diagnosis of Nipah virus infection and for further research on Nipah virus pathogenesis.  (+info)

An encephalitis outbreak was investigated in Faridpur District, Bangladesh, in April-May 2004 to determine the cause of the outbreak and risk factors for disease. Biologic specimens were tested for Nipah virus. Surfaces were evaluated for Nipah virus contamination by using reverse transcription-PCR (RT-PCR). Thirty-six cases of Nipah virus illness were identified; 75% of case-patients died. Multiple peaks of illness occurred, and 33 case-patients had close contact with another Nipah virus patient before their illness. Results from a case-control study showed that contact with 1 patient carried the highest risk for infection (odds ratio 6.7, 95% confidence interval 2.9-16.8, p<0.001). RT-PCR testing of environmental samples confirmed Nipah virus contamination of hospital surfaces. This investigation provides evidence for person-to-person transmission of Nipah virus. Capacity for person-to-person transmission increases the potential for wider spread of this highly lethal pathogen and highlights the
Human Nipah outbreaks recur in a specific region and time of year in Bangladesh. Fruit bats are the reservoir host for Nipah virus. We identified 23 introductions of Nipah virus into human populations in central and northwestern Bangladesh from 2001 through 2007. Ten introductions affected multiple persons (median 10). Illness onset occurred from December through May but not every year. We identified 122 cases of human Nipah infection. The mean age of case-patients was 27 years; 87 (71%) died. In 62 (51%) Nipah virus-infected patients, illness developed 5-15 days after close contact with another Nipah case-patient. Nine (7%) Nipah case-patients transmitted virus to others. Nipah case-patients who had difficulty breathing were more likely than those without respiratory difficulty to transmit Nipah (12% vs. 0%, p = 0.03). Although a small minority of infected patients transmit Nipah virus, more than half of identified cases result from person-to-person transmission. Interventions to prevent virus ...
Looking for Nipah virus encephalitis? Find out information about Nipah virus encephalitis. general term used to describe a diffuse inflammation of the brain and spinal cord, usually of viral origin, often transmitted by mosquitoes, in contrast to... Explanation of Nipah virus encephalitis
TY - JOUR. T1 - Monoclonal antibody-based immunohistochemical diagnosis of Malaysian Nipah virus infection in pigs. AU - Tanimura, N.. AU - Imada, T.. AU - Kashiwazaki, Y.. AU - Shahirudin, S.. AU - Sharifah, S. H.. AU - Aziz, A. J.. N1 - Funding Information: This study was supported by a joint study project of the Japan International Cooperation Agency and the Veterinary Research Institute, Malaysian Ministry of Agriculture, on the epidemiology, pathogenesis and molecular characterization of the Nipah virus. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2004/8. Y1 - 2004/8. N2 - Formalin-fixed, paraffin wax-embedded tissues of three Malaysian farm pigs naturally infected with Nipah virus were used to investigate the value of anti-Nipah virus mouse monoclonal antibodies (Mabs) and rabbit polyclonal antibody for immunohistochemical diagnosis. Mabs 11F6 and 12A5 gave intense immunolabelling in lung tissue that had been fixed in 10% neutral buffered formalin for about 4 years, ...
TY - JOUR. T1 - A Human Lung Xenograft Mouse Model of Nipah Virus Infection. AU - Valbuena, Gustavo. AU - Halliday, Hailey. AU - Borisevich, Viktoriya. AU - Goez, Yenny. AU - Rockx, Barry. PY - 2014/4. Y1 - 2014/4. N2 - Nipah virus (NiV) is a member of the genus Henipavirus (family Paramyxoviridae) that causes severe and often lethal respiratory illness and encephalitis in humans with high mortality rates (up to 92%). NiV can cause Acute Lung Injury (ALI) in humans, and human-to-human transmission has been observed in recent outbreaks of NiV. While the exact route of transmission to humans is not known, we have previously shown that NiV can efficiently infect human respiratory epithelial cells. The molecular mechanisms of NiV-associated ALI in the human respiratory tract are unknown. Thus, there is an urgent need for models of henipavirus infection of the human respiratory tract to study the pathogenesis and understand the host responses. Here, we describe a novel human lung xenograft model in ...
Human infection with Nipah virus is often fatal, and there are no approved therapeutics. Lo et al. tested the nucleotide prodrug remdesivir (GS-5734), which has shown activity against other pathogens such as Ebola virus, in a nonhuman primate model. Animals were administered a lethal dose of Nipah virus, and half were treated daily with remdesivir starting 24 hours later. All control animals had to be euthanized, and although treated animals had some mild symptoms, all survived. These results indicate that efficacy of remdesivir should be tested in human Nipah virus infection. ...
TY - JOUR. T1 - Nipah Virus C and W Proteins Contribute to Respiratory Disease in Ferrets. AU - Satterfield, Benjamin A.. AU - Cross, Robert W.. AU - Fenton, Karla A.. AU - Borisevich, Viktoriya. AU - Agans, Krystle N.. AU - Deer, Daniel J.. AU - Graber, Jessica. AU - Basler, Christopher F.. AU - Geisbert, Thomas W.. AU - Mirea, Chad E.. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Nipah virus (NiV) is a highly lethal paramyxovirus that recently emerged as a causative agent of febrile encephalitis and severerespiratory disease in humans. The ferret model has emerged as the preferred small-animal model with which to study NiV disease,but much is still unknown about the viral determinants of NiV pathogenesis, including the contribution of the C protein inferrets. Additionally, studies have yet to examine the synergistic effects of the various P gene products on pathogenesis in animalmodels. Using recombinant NiVs (rNiVs), we examine the sole contribution of the NiV C protein and the combined contributionsof ...
Nipah virus (NiV) is a highly pathogenic zoonotic agent in the family Paramyxoviridae that is maintained in nature by bats. Outbreaks have occurred in Malaysia, Singapore, India, and Bangladesh and have been associated with 40 to 75% case fatality rates. There are currently no vaccines or postexposure treatments licensed for combating human NiV infection. Four groups of ferrets received a single vaccination with different recombinant vesicular stomatitis virus vectors expressing: Group 1, control with no glycoprotein; Group 2, the NiV fusion protein (F); Group 3, the NiV attachment protein (G); and Group 4, a combination of the NiV F and G proteins. Animals were challenged intranasally with NiV 28 days after vaccination. Control ferrets in Group 1 showed characteristic clinical signs of NiV disease including respiratory distress, neurological disorders, viral load in blood and tissues, and gross lesions and antigen in target tissues; all animals in this group succumbed to infection by day 8. Importantly
FIG. 3: FRUIT BATS ARE THE NATURAL RESERVOIRS OF NIPAH VIRUS. Diagnosis: Laboratory diagnosis of Nipah virus infection is made using reverse transcriptase polymerase chain reaction (RT-PCR) from throat swabs, cerebrospinal fluid, urine and blood analysis during acute and convalescent stages of the disease. IgG and IgM antibody detection can be done after recovery to confirm Nipah virus infection. Immunohisto chemistry on tissues collected during autopsy also confirms the disease 12. Viral RNA can be isolated from the saliva of infected persons.. The disease is very difficult to diagnose based on clinical symptoms alone. However, a definitive diagnosis can be made based on laboratory tests, which are briefly highlighted below:. ELISA: ELISA stands for Enzyme-linked Immunosorbent Assay. It is a very accurate and sensitive immunological test for detecting antigens or antibodies, depending upon the format of the ELISA technique used.. In case for NiV infection, antibodies will be generated ...
We investigated an outbreak of encephalitis in Tangail District, Bangladesh. We defined case-patients as persons from the outbreak area in whom fever developed with new onset of seizures or altered mental status from December 15, 2004, through January 31, 2005. Twelve persons met the definition; 11 (92%) died. Serum specimens were available from 3; 2 had immunoglobulin M antibodies against Nipah virus by capture enzyme immunoassay. We enrolled 11 case-patients and 33 neighborhood controls in a case-control study. The only exposure significantly associated with illness was drinking raw date palm sap (64% among case-patients vs. 18% among controls, odds ratio [OR] 7.9, p = 0.01). Fruit bats (Pteropus giganteus) are a nuisance to date palm sap collectors because the bats drink from the clay pots used to collect the sap at night. This investigation suggests that Nipah virus was transmitted from P. giganteus to persons through drinking fresh date palm sap ...
This activity complements the video Virus Hunter: Monitoring Nipah Virus in Bat Populations. Students explore cases of Nipah virus infection, analyze evidence, and make calculations and predictions based on data.
Nipah virus was first identified in 1999 during an outbreak of illness affecting pig farmers and others living in close contact with pigs. Over 100 human deaths were reported, and over a million pigs were killed to stop the outbreak. No cases of person-to-person spread were reported.. In 2001, there was an outbreak of Nipah virus in people in Bangladesh, and a separate outbreak in a hospital in India. In both countries, person-to-person transmission occurred. Outbreaks in Bangladesh happen nearly every year - with over 300 confirmed cases occurring there from 2001 to 2015.. ...
Anti Niv IgG ELISA Anti Nipah Virus product information; Anti Niv IgG ELISA Anti Nipah Virus is available 3 times from supplier NiV Gen at Gentaur.com shop
LA JOLLA, CA - What began as a summer internship project designed for an undergraduate student evolved into a one-year study of one of the deadliest, but little known viruses. Researchers at The Scripps Research Institute (TSRI) have now solved the structure of a key protein in the Nipah virus, which could pave the way for the development of a much-needed antiviral drug. This structure shows how key pieces of the viruss machinery are oriented and tethered together, said TSRI Professor Erica Ollmann Saphire, senior author of the study. This is part of a larger program to illuminate how these deadly viruses replicate. The Nipah virus is an emerging pathogen found in Southeast Asia, particularly Malaysia, Bangladesh and India. The first outbreak was in 1997, followed by yearly outbreaks since then, with increasing mortality rates. Carried by the flying fruit bat, the virus causes only mild illness in pigs, dogs, cats, horses, goats and sheep, which also spread the disease. But in humans, ...
Nipah virus is an infectious virus with high zoonotic potential and mortality60. Patients suffer with permanent neurological conditions such as encephalopathy, facial paralysis, cerebral atrophy and cervical dystonia post recovery60,61. The mortality rate in recent outbreaks varied between 32-92%60. Many broad-spectrum therapies have been developed and tested in the animal models. The drug Favipiravir shows good recovery rate while other G-protein specific antibodies are also in the pipeline60. However, these therapies cannot undo the existing irreversible neurological damage caused by NiV. In that case, a viral specific vaccine offers a promising solution to stimulate the immune system prior to the actual infection. Many approaches were used to develop a suitable vaccine. A subunit epitope-based vaccine development remains a good alternative as the risk associated with virulence and incomplete attenuation is completely eliminated. Epitope based vaccines for Nipah virus were first derived by ...
TY - JOUR. T1 - Nipah virus transmission in south Asia. T2 - Exploring the mysteries and addressing the problems. AU - Gurley, Emily S.. AU - Luby, Stephen P.. PY - 2011/8/1. Y1 - 2011/8/1. KW - Bangladesh. KW - Nipah virus. KW - emerging infection. KW - zoonoses. UR - http://www.scopus.com/inward/record.url?scp=80051988864&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=80051988864&partnerID=8YFLogxK. U2 - 10.2217/fvl.11.70. DO - 10.2217/fvl.11.70. M3 - Review article. AN - SCOPUS:80051988864. VL - 6. SP - 897. EP - 900. JO - Future Virology. JF - Future Virology. SN - 1746-0794. IS - 8. ER - ...
The Nipah virus infection starts with 3-14 days of fever and headache, followed by drowsiness, disorientation and mental confusion. The acute encephalitis then progresses to coma within 24-48 hours.
Outbreaks of Hendra (HeV) and Nipah (NiV) viruses have been reported starting in 1994 and 1998, respectively. Both viruses are capable of causing fatal disease in humans and effecting great economical loss in the livestock industry. Through screening of hybridomas derived from mice immunized with γ-irradiated Nipah virus, we identified two secreted antibodies; one reactive with the nucleocapsid (N) protein and the other, the phosphoprotein (P) of henipaviruses. Epitope mapping and protein sequence alignments between NiV and HeV suggest the last 14 amino acids of the carboxyl terminus of the N protein is the target of the anti-N antibody. The anti-P antibody recognizes an epitope in the amino-terminal half of P protein. These monoclonal antibodies were used to develop two antigen capture ELISAs, one for virus detection and the other for differentiation between NiV and HeV. The lower limit of detection of the capture assay with both monoclonal antibodies was 400 pfu. The anti-N antibody was used to
A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Nipah virus encephalitis
Nipah virus infection is an emerging disease endemic to Southeast Asia, carried by fruit bats of the genus Pteropus. It can affect humans, pigs and occasionally other domesticated animals.
Measles virus and Nipah virus belong to the only two paramyxovirus genera that use protein-based receptors for entry. Studies with the measles virus envelope have shown that complex modifications to its attachment protein, including disruption of the binding site for its natural receptors and appending scFv or other targeting domains, result in specific retargeting to desired cell populations in vitro and in vivo (9, 51). Some of these modifications have been adapted successfully to make scFv-directed-targeting lentiviral MeVpp (7, 52). However, preexisting neutralizing antibodies due to widespread MeV vaccination may compromise the transduction efficiency of MeVpp administered in vivo, although deletion of immunodominant epitopes on MeV-H and other modifications have reduced the sensitivity of MeVpp to serum neutralization in vitro (53). In contrast, NiV is an emerging and lethal pathogen thus far confined to Southeast Asia (54). Thus, it is unlikely that preexisting antibodies will pose a ...
12/26/18. 12/19/18 Steven Bedard response. Dear Mr. Tuttle,. Thank you so much for your concern, and for reading the bioGraphic story about Nipah virus. I really appreciate it. I assure you that I am a strong proponent of bats and the tremendously important ecological roles they play. I also think that bats are simply amazing creatures in their many forms and functions. (When you have time, please take a look at bioGraphics other bat stories as evidence of that appreciation: Glimmers in the Dark, Battling Disease, Bat Ballet, and Agave Whisperers.). He went on to explain it is never his intention to vilify or advocate killing of bats and hopes he is being clear.. 12/20/18 Merlin response. Dear Steven,. I do not doubt your concern for bats or your good intentions. As Ive commented, most of your article was just fine. My complaint lies in labeling bats to be the most dangerous disease-spreading mammals. Our background experiences are apparently strikingly different. Mine regarding the impact ...
The outbreak in Malaysia began on a large-scale, industrialized pig farm that had fruit trees planted next to the pig enclosures. Giant fruit bats-which carry the virus and occasionally shed it, but are not affected by it-fed on mangoes in trees that overhung the pig pens and dropped bits of fruit contaminated with saliva, and occasionally nipah virus, into the pens where pigs were able to eat them. Farm workers became infected by pigs that developed severe respiratory disease and spread the virus by coughing. The movement of infected pigs throughout the country drove the outbreak until Malaysian health officials were able to stop its spread.. ...
The death toll from an outbreak of the rare Nipah virus in southern India jumped to 10 Tuesday with more than 90 people quarantined to try to stem ...
In 1998-99 an outbreak of a new virus, now called the Nipah virus, killed more than 100 people and thousands of pigs in Malaysia. Our scientists were part of the international task force to tackle the virus and later participated in vaccine evaluation.
UCLA scientists have discovered how the deadly Nipah virus infiltrates human cells to cause encephalitis. Designated as a potential bioterrorism agent by the National Biodefense Research Agenda, the virus exploits a protein essential to embryonic development to enter cells and launch its attack.
A new vaccine developed by a team of researchers may protect people and livestock from the deadly Nipah virus. The virus, upon which the Hollywood blockbuster C
In our newest podcast, we talk about autoimmune diseases linked to the Kissing Disease, concerns over the emerging Nipah Virus, and how fetal immunity may be causing babies to be born early.
The highly lethal Hendra and Nipah viruses have been described for little more than a decade, yet within that time have been aetiologically associated with major livestock and human health impacts, albeit on a limited scale. Do these emerging pathogens pose a broader threat, or are they inconsequential viral chatter. Given their lethality, and the evident multi-generational human-to-human transmission associated with Nipah virus in Bangladesh, it seems prudent to apply the precautionary principle. While much is known of their clinical, pathogenic and epidemiologic features in livestock species and humans, a number of fundamental questions regarding the relationship between the viruses, their natural fruit-bat host and the environment remain unanswered. In this paper, we pose and probe these questions in context, and offer perspectives based primarily on our experience with Hendra virus in Australia, augmented with Nipah virus parallels.. ...
- A member of Paramyxoviridae, genus Henipavirus - Name taken from Sungai Nipah, Seremban (where the virus is first isolated) Epidemiology - Southeast asia - Pig farms (from infected pig) From fruit eating bats (reservoir) -| the pigs eat the partially eaten fruits left over by the infected bats Bat -| pig -| human -|…
Nipah virus (NiV) is a zoonotic emerging pathogen that can cause severe and often fatal respiratory disease in humans. The pathogenesis of NiV infection of the human respiratory tract remains unknown. Reactive oxygen species (ROS) produced by airway epithelial cells in response to viral infections contribute to lung injury by inducing inflammation and oxidative stress; however, the role of ROS in NiV-induced respiratory disease is unknown. To investigate whether NiV induces oxidative stress in human respiratory epithelial cells, we used oxidative stress markers and monitored antioxidant gene expression. We also used ROS scavengers to assess their role in immune response modulation. Oxidative stress was confirmed in infected cells and correlated with the reduction in antioxidant enzyme gene expression. Infected cells treated by ROS scavengers resulted in a significant decrease of the (F2)-8-isoprostane marker, inflammatory responses and virus replication. In conclusion, ROS are induced during NiV
Lini Puthussery, the nurse who attended to Sabith, was one of them. She used neither gloves nor a mask. {Some of us involved in Sustainable Waste Management have found that the Corporation conservancy staff simply do not want to wear masks, gloves and aprons supplied to them, in spite of warning about consequences. Just like opposition to helmet wearing from two-wheel riders. Even most of them with helmets on, ride unstrapped. Whom are they cheating? The other day, I saw a photo of TN health secretary at an H1N1 ward without the mask!} Others, who barely knew Sabith, assisted him too. In the ward, everyone was trying to help each other, says Govindakarnavar. One of them, a fellow patient, attempted to feed Sabith. A family member accompanying another patient cleaned Sabiths vomit. These well-meaning acts became death sentences. In contrast, patients who did not come into physical contact - those too sick to get up from their beds, for instance - did not contract the virus. Even a ward ...
In 2012, cases of lethal pneumonia among Chinese miners prompted the isolation of a rat-borne henipavirus (HNV), Mòjiāng virus (MojV). Although MojV is genetically related to highly pathogenic bat-borne henipaviruses, the absence of a conserved ephrin receptor-binding motif in the MojV attachment glycoprotein (MojV-G) indicates a differing host-cell recognition mechanism. Here we find that MojV-G displays a six-bladed β-propeller fold bearing limited similarity to known paramyxoviral attachment glycoproteins, in particular at host receptor-binding surfaces. We confirm the inability of MojV-G to interact with known paramyxoviral receptors in vitro, indicating an independence from well-characterized ephrinB2/B3, sialic acid and CD150-mediated entry pathways. Furthermore, we find that MojV-G is antigenically distinct, indicating that MojV would less likely be detected in existing large-scale serological screening studies focused on well-established HNVs. Altogether, these data indicate a unique host
This activity complements the video Virus Hunter: Monitoring Nipah Virus in Bat Populations. Students explore cases of Nipah virus infection, analyze evidence, and make calculations and predictions based on data.. ...
Authors: Singh RK, Dhama K, Chakraborty S, Tiwari R, Natesan S, Khandia R, Munjal A, Vora KS, Latheef SK, Karthik K, Singh Malik Y, Singh R, Chaicumpa W, Mourya DT Abstract Nipah (Nee-pa) viral disease is a zoonotic infection caused by Nipah virus (NiV), a paramyxovirus belonging to the genus Henipavirus of the family Paramyxoviridae. It is a biosafety level-4 pathogen, which is transmitted by specific types of fruit bats, mainly Pteropus spp. which are natural reservoir host. The disease was reported for the first time from the Kampung Sungai Nipah village of Malaysia in 1998. Human-to-human transmission also occu ...
Dimiter Dimitrov, Ph.D., senior author of the Cell newsletter and director of Pitts Center for Antibody Therapeutics, was one amongst the first to gape neutralizing antibodies for the licensed SARS coronavirus in 2003. Within the following years, his team came all the plan in which through potent antibodies in opposition to many varied infectious ailments, alongside side these induced by MERS-CoV, dengue, Hendra and Nipah viruses. The antibody in opposition to Hendra and Nipah viruses has been evaluated in humans and authorized for clinical exercise on a compassionate basis in Australia.. Scientific trials are testing convalescent plasma - which contains antibodies from people that already had COVID-19 - as a therapy for these battling the infection, however there isnt sufficient plasma for folks that would maybe well also need it, and it isnt proven to work.. Thats why Dimitrov and his team position out to isolate the gene for one or extra antibodies that block the SARS-CoV-2 virus, which ...
Nipah virus (NiV) is a deadly virus with a high mortality rate that has affected many developing countries in the past. According to the Centers for Disease Control and Prevention (CDC), many economically deprived countries such as Madagascar, Cambodia, and Thailand are also at high risk for future outbreaks. The first case of NiV was reported in 1998 and almost two decades later, little scientific progress has been made in finding a proper treatment and prevention vaccine. As many developing countries are not properly equipped to fight the infection, it is vital to properly educate the health systems. The aim of this review is to provide an epidemiological background as well as to understand the transmission routes, presentation, and the diagnosis and prevention of this deadly virus.
The virus was characterised in 1999 after it has caused an outbreak of infectious encephalitis. Since there are no vaccination programmes against the virus, no neutralising antibodies are expected in the patients. At the same time, no hazards can be expected from the virus itself, since only its envelope proteins are used in a modified form.. For receptor targeting, Buchholz and co-workers developed 27 different variants of envelope proteins of the Nipah virus and addressed eight different cell surface proteins. Gene transfer assays were performed to test whether the respective lentiviral vectors would be able to enter into target receptor-positive cell types, and, if so, how efficiently they were able to do so.. The researchers established that cell entry worked best if the distance of the particles from the cell membrane was less than 100 Å. If this distance was longer, cell entry and thus gene delivery became inefficient or not functional at all. As the researchers interpret these results, ...
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The death toll due to Nipah rose to 13 in Kerala, with one more person succumbing to the deadly virus here on Sunday. Twenty six-year-old Abin, hailing from Palazhi in the district, died at a private hospital after battling for life for one week, official sources said.
<p><span style="font-size: 10pt; font-family: Arial;">Basic preventative methods can help limit the transmission of Nipah virus, say Bangladesh scientists.</span></p>
Our group The group, led by Dr Dalan Bailey, works on a range of RNA viruses including SARS-CoV-2, Nipah virus, respiratory syncytial viruses and the morbilliviruses. Funded by the Medical Research Council (MRC), Biotechnology and Biological Sciences Research Council (BBSRC) and the Department of Health and Social Care (DHSC), the Viral Glycoproteins group investigates viral
Most emerging zoonoses dont affect large numbers of people, but are quite deadly. In the case of SARS the death rate was estimated as high as 10 per cent, but the MERS virus has killed 40 per cent of humans infected. Its not good, but on the optimistic side were not talking thousands or hundreds of thousands of cases says Watson. The animal toll has been much greater. When the Nipah virus broke out in Malaysia in the late 1990s there were relatively few human deaths but five million pigs had to be slaughtered in order to wipe it out.. Watson says its unclear why some viruses mutate into deadly variants and some do not. It is really unpredictable, however many viruses are successful because they do not kill their human hosts and therefore get better transmission from person to person.. He says in spite of the fear factor around the more recently emerging zoonoses, diseases endemic to humans, like measles, and meningococcal disease remain more deadly Certainly each new zoonotic disease ...
Overlaying maps of where the zoonotic (animal-borne) diseases have occurred, with population maps, allowed a pattern of relationships to emerge, said Levy. Understanding these relationships is a first step in prediction and can lead to better surveillance and health care responses.. Emerging diseases-defined as newly identified pathogens, or old ones moving to new regions-have caused devastating outbreaks already. The research shows that disease emergences have roughly quadrupled over the past 50 years. Some 60 percent of the diseases traveled from animals to humans, and the majority of those came from wild creatures. With data corrected for lesser surveillance done in poorer countries, hot spots jump out in areas spanning sub-Saharan Africa, India and China, as well as smaller spots in Europe, and North and South America.. Some pathogens may be picked up by hunting or accidental contact; others, such as Malaysias Nipah virus, go from wildlife to livestock, then to people. Humans have ...
It is an exciting time to study virology! In the last decade, weve seen new viruses-SARS, H1N1 influenza, and Nipah viruses among them-emerging around the world; Ebola Chikungunya, and West Nile viruses have re-emerged; and the AIDS epidemic continues to sweep across sub-Saharan Africa and parts of Asia. New vaccines for HIV, smallpox, avian influenza and genital herpes are sorely needed. New antivirals for Dengue, hepatitis C and HIV viruses are also desperately needed. The role of such viruses as Merkel cell polyoma, papilloma, Kaposis sarcoma and Epstein-Barr virus in human cancer highlight challenges to prevent and treat these diseases. Researchers at Harvard University are working on all these biomedical problems. They conduct basic research defining new molecular structures of viruses and virus-encoded enzymes, new mechanisms within cells for molecular and organelle trafficking and function, and new mechanisms that control cell growth. Harvard researchers are among the world leaders in ...
It is an exciting time to study virology! In the last decade, weve seen new viruses-SARS, H1N1 influenza, and Nipah viruses among them-emerging around the world; Ebola Chikungunya, and West Nile viruses have re-emerged; and the AIDS epidemic continues to sweep across sub-Saharan Africa and parts of Asia. New vaccines for HIV, smallpox, avian influenza and genital herpes are sorely needed. New antivirals for Dengue, hepatitis C and HIV viruses are also desperately needed. The role of such viruses as Merkel cell polyoma, papilloma, Kaposis sarcoma and Epstein-Barr virus in human cancer highlight challenges to prevent and treat these diseases. Researchers at Harvard University are working on all these biomedical problems. They conduct basic research defining new molecular structures of viruses and virus-encoded enzymes, new mechanisms within cells for molecular and organelle trafficking and function, and new mechanisms that control cell growth. Harvard researchers are among the world leaders in ...
The ECDC Communicable Disease Threats Report (CDTR) is a weekly bulletin for epidemiologists and health professionals on active public health threats. This issue covers the period 27 May - 2 June 2018 and includes updates on dengue, ebola virus disease, yellow fever, Cholera, monitoring environmental suitability of Vibrio growth in the Baltic Sea, Nipah virus disease, West Nile virus, Salmonella Agona, Rapid emergence of resistance to new antibiotic. β-lactamase inhibitor combination Ceftazidime-Avibactam. ...
The ECDC Communicable Disease Threats Report (CDTR) is a weekly bulletin for epidemiologists and health professionals on active public health threats. This issue covers the period 27 May - 2 June 2018 and includes updates on dengue, ebola virus disease, yellow fever, Cholera, monitoring environmental suitability of Vibrio growth in the Baltic Sea, Nipah virus disease, West Nile virus, Salmonella Agona, Rapid emergence of resistance to new antibiotic. β-lactamase inhibitor combination Ceftazidime-Avibactam. ...
Background and Objective: In 1998/99, an outbreak of Nipah virus encephalitis occurred in several pig-farming communities in Malaysia. It was associated with a high mortality rate and persistent neurological defi cits among many survivors. This mixed method study aimed to examine the longterm socio-economic consequences of the illness on affected pig farmers and their families in Bukit Pelanduk, Negeri Sembilan. Methods: A quantitative cross sectional survey was conducted in 2008 on 78 former patients or their kin from 61 households (46.2% males, mean age = 48.7 years) in Bukit Pelanduk via face-to-face interviews. This was followed by qualitative in-depth interviews with 20 respondents. Results: The immediate treatment costs were not a major burden to most households. Majority of the patients (92%) required inpatient care and most obtained free care from public hospitals. Households relied mainly on savings and support provided by the public and family members during the outbreak. However, many ...
Nipah and Hendra viruses are emergent paramyxoviruses, causing disease characterized by rapid onset and high mortality rates, resulting in their classification as Biosafety Level 4 pathogens. Their attachment glycoproteins are essential for the recognition of the cell-surface receptors ephrin-B2 (EFNB2) and ephrin-B3 (EFNB3). Here we report crystal structures of both Nipah and Hendra attachment glycoproteins in complex with human EFNB2. In contrast to previously solved paramyxovirus attachment complexes, which are mediated by sialic acid interactions, the Nipah and Hendra complexes are maintained by an extensive protein-protein interface, including a crucial phenylalanine side chain on EFNB2 that fits snugly into a hydrophobic pocket on the viral protein. By analogy with the development of antivirals against sialic acid binding viruses, these results provide a structural template to target antiviral inhibition of protein-protein interactions.
Hendra and Nipah virus, which constitute the genus Henipavirus, are zoonotic paramyxoviruses that have been associated with sporadic outbreaks of severe disease and mortality in humans since their emergence in the late 1990s. Similar to other paramyxoviruses, their ability to evade the host interferon (IFN) response is conferred by the P gene. The henipavirus P gene encodes four proteins; the P, V, W and C proteins, which have all been described to inhibit the antiviral response. Further studies have revealed that these proteins have overlapping but unique properties which enable the virus to block multiple signaling pathways in the IFN response. The best characterized of these is the JAK-STAT signaling pathway which is targeted by the P, V and W proteins via an interaction with the transcription factor STAT1. In addition the V and W proteins can both limit virus-induced induction of IFN but they appear to do this via distinct mechanisms that rely on unique sequences in their C-terminal domains. The
Hendra virus (HeV) was first described in 1994 following the outbreak of a novel disease fatally affecting horses and humans in south-east Queensland. Sporadic outbreaks continue to be identified (in 1999, 2004, 2006 & 2007), with a total of 30 equine known cases (75% CFR) and 4 known human cases (50% CFR) to date.. Bats (flying foxes) have been identified as the natural host of the virus.. A closely related virus (Nipah virus - NiV) was responsible for a major outbreak of disease in pigs and humans in Malaysia in 1998-9, and more recently has been identified as the cause of seasonal clusters of human disease (with a 75% case fatality rate) in Bangladesh. The strains of Nipah virus identified in Bangladesh differ genetically from those identified in Malaysia, and feature direct bat-human and human-human transmission. In Australia, the existence of Hendra virus strain variation became evident in a recent equine case which was initially mis-diagnosed by animal health authorities, but subsequently ...
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The report in which the findings appear is the first from a collaboration formed in 2008 by the Centers for Disease Control and Prevention and several nongovernmental agencies, including Columbias Center for Infection and Immunity (CII), to assess the global public-health risk of illegally shipped wildlife products.. Each year, thousands of wildlife products, including live animals, body parts, and hides, are illegally shipped into the United States. Many originate in countries with endemic plagues such as H5N1 influenza, Nipah virus, and simian retroviruses. In fact, the fictional pandemic in the 2011 Hollywood thriller Contagion was based on actual outbreaks of Nipah virus in Bangladesh and India, where infected bats presumably transmitted the disease to humans by contaminating the local food supply.. The study, Zoonotic Viruses Associated with Illegally Imported Wildlife Products, was published on January 10, 2012, in PloS ONE. The CII-affiliated authors are Simon J. Anthony, DPhil; Tracie ...
These Pathogen Safety Data Sheets, regulated under Workplace Hazardous Materials Information System (WHMIS) legislation, are produced for personnel working in the life sciences as quick safety reference material relating to infectious micro-organisms.
പലകാരണങ്ങള്‍കൊണ്ടും പനി ഉണ്ടാകാമെങ്കിലും മഴക്കാലത്ത് പനി ഉണ്ടാവുമ്പോള്‍ അത് പകര്‍ച്ചപ്പനികളിലേതെങ്കിലും ആണോ എന്ന് ബലമായി സംശയിക്കണം. പനി ഏതായാലും അത്.Dengue Fever. Malaria. Chikungunya. Zika. Zika Virus. Fever. Common Fever. Viral Fever. H1NI Fever. Nipah. Fever. Fever dead. Rain Havoc. Kerala Flood.health.Health News. Malayalam Health News. Health Tips. Manorama Online
Scientists have unmasked a killer responsible for the deaths of at least 95 people in Malaysia in the last 6 months, most of them pig farm workers. The culprit, named the Nipah virus for the small town from whence the strain was first identified, is a previously unknown virus that replicates in pigs and seems to be easily transmitted to humans. It is closely related to another notorious agent, the Hendra virus, which surfaced in Australia in 1994 and killed two people and more than a dozen horses. But the new virus spreads much more rapidly, making it an emerging virus of grave concern, says John Mackenzie, head of the department of microbiology and parasitology at the University of Queensland in Brisbane, Australia.. The countrys health authorities initially assumed they were dealing with an outbreak of Japanese encephalitis (JE), which causes similar symptoms, and some critics have accused the Malaysian government of being slow to consider alternative causes. Indeed, even now authorities ...
Nipah virus (NiV) continues to cause outbreaks of fatal human encephalitis due to spillover from its bat reservoir. We determined that a single dose of replication-defective vesicular stomatitis virus (VSV)-based vaccine vectors expressing either the NiV fusion (F) or attachment (G) glycoproteins protected hamsters from over 1000 times LD50 NiV challenge. This highly effective single-dose protection coupled with an enhanced safety profile makes these candidates ideal for potential use in livestock and humans.CC999999/Intramural CDC HHS/United StatesT32 AI007610/AI/NIAID NIH HHS/United StatesU54 AI057158/AI/NIAID NIH HHS/United StatesU54-AI057158/AI/NIAID NIH HHS/United States2015-01-01T00:00:00Z24184127PMC38748897469vault:2352 ...
Research and development of technologies for outbreaks has received extensive attention. WHOs research and development blueprint is the main source of global guidance, identifying 10 prioritised pathogens, each with roadmaps and target product profiles.37 The Global Research Collaboration for Infectious Disease Preparedness is working to set a research agenda and tackle scientific, legal, ethical, and financial challenges to facilitate a rapid and effective research response during outbreaks.38. Vaccine development has emerged as a clear priority. The Coalition for Epidemic Preparedness Innovations (CEPI) was launched in 2017 and began funding vaccine projects in 2018.39 Although many are enthusiastic about the rapid pace of CEPIs development, concerns persist about sustaining the engagement of major vaccine producers and the appropriateness of its priorities (MERS, Lassa, and Nipah viruses).40 Adequate vaccine stockpiles also remain a challenge, even with the United States September 2017 ...
The order Mononegavirales is the taxonomic home of numerous related viruses. Members of the order that are commonly known are, for instance, Ebola virus, human respiratory syncytial virus, measles virus, mumps virus, Nipah virus, and rabies virus. All of these viruses cause significant disease in humans. Many very important pathogens of nonhuman animals and plants are also members of this order. ...
Early pathogen exposure detection allows better patient care and faster implementation of public health measures (patient isolation, contact tracing). Existing exposure detection most frequently relies on overt clinical symptoms, namely fever, during the infectious prodromal period. We have developed a robust machine learning based method to better detect asymptomatic states during the incubation period using subtle, sub-clinical physiological markers. Starting with highresolution physiological waveform data from non-human primate studies of viral (Ebola, Marburg, Lassa, and Nipah viruses) and bacterial (Y. pestis) exposure, we processed the data to reduce short-term variability and normalize diurnal variations, then provided these to a supervised random forest classification algorithm and post-classifier declaration logic step to reduce false alarms. In most subjects detection is achieved well before the onset of fever; subject cross-validation across exposure studies (varying viruses, exposure ...
https://www.npr.org/sections/goatsandsoda/2017/02/25/515258818/a-taste-for-pork-helped-a-deadly-virus-jump-to-humans. In 1999, in a small town in Malaysia, a scientist named Dr. Kaw Bing Chua made a discovery crucial for the restructuring of the agriculture and farming industry across Malaysia (as well as Singapore, the Philippines, and several other countries). Chua discovered the virus later to known by the name of Nipah. Chua, a grad student studying virology at the time pinpointed this virus as one spreading across the country, yet no one at the time believed it. Over the course of the next year a disease more deadly than Ebola was spreading rapidly throughout the town of Nipah, Malaysia. It eventually caught the attention of the government, and since most common viruses were spread through mosquitoes, the government treated it that way. However, after months of efforts to decrease the rate of spreading, nothing was working. This is when Chua comes back into the story. Chua was adamant that ...
To see how easy it would be for someone to embark on this kind of work (at least somebody in a university setting) I got in contact with one of the gene synthesis companies out there today. I work on a group of RNA viruses known as the paramyxoviruses - they include human pathogens like measles, mumps, RSV, nipah and hendra. Pretty dangerous stuff. If you wanted to get the entire genome synthesized (about 15,000 base pairs) it would cost you only US$16,818.50. Only. Also with a considerable time delay and no guarantee of delivery. Turns out viral genomes are pretty complicated. And even once you received the viral DNA you would then have to go about turning into a virus, which is not a particularly easy affair ...
Summary: Det finns olika berättelser om hur man kommer till världen. Alla berättelser är lika viktiga. Vid en viss ålder börjar barn undra och fråga om hur de blev till och hur de hänger ihop med sin övriga familj. Som vuxna svarar vi på barnets frågor för att skapa förståelse och för att barnet skall få tillgång till sin egen berättelse. Ibland läser vi böcker för barnet för igenkänning och förståelse. En av författarens vänner är mamma med hjälp av donator och den mamman sa vid ett tillfälle att det borde finnas en barnbok om detta. Ann-Katrine Engström sa; Då skall jag skriva den till er! Tanken växte och Ann-Katrine såg att det fanns ett behov av denna bok också hos andra familjer och människor som möter barn från olika familjekonstellationer. Så här är den nu, boken om Mamman och fröet! En bok som på ett lättsamt sätt, med färgglada illustrationer och på barnets nivå förklarar en mammas längtan och hur man kan komma till världen genom en ...
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Flying foxes are also reservoirs of henipaviruses such as Hendra virus and Nipah virus. Hendra virus was first identified in ... A 2014 study of the Indian flying fox and Nipah virus found that while Nipah virus outbreaks are more likely in areas preferred ... Nipah virus was first identified in 1998 in Malaysia. Since 1998, there have been several Nipah outbreaks in Malaysia, ... Henipavirus outbreaks overlaid on flying fox distribution map, with Nipah virus as blue icons and Hendra virus as red icons. ...
Kerala Nipah virus (2018). *Équateur province Ebola (2018). *Kivu Ebola (2018-2020) ... "Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries.", Virol. J., 7 (52). ... "Origin of the Measles Virus: Divergence from Rinderpest Virus Between the 11th and 12th Centuries". Virology. 7: 52-55. doi ...
Malaysia Nipah virus outbreak. 1998-1999. Petronas Twin Towers Grand Opening. 1999. ...
Kerala Nipah virus (2018). *Équateur province Ebola (2018). *Kivu Ebola (2018-2020) ...
Malaysia Nipah virus outbreak. 1998-1999. Petronas Twin Towers Grand Opening. 1999. ...
Kerala Nipah virus (2018). *Équateur province Ebola (2018). *Kivu Ebola (2018-2020) ...
Kerala Nipah virus (2018). *Équateur province Ebola (2018). *Kivu Ebola (2018-2020) ...
Kerala Nipah virus (2018). *Équateur province Ebola (2018). *Kivu Ebola (2018-present) ...
talk , contribs)‎ (→‎Predators, parasites, and diseases: Nipah and Hendra viruses both in Henipavirus, ref) ...
Nipah virus disease. P. *Pandemic. *Pestilence. *Plague of Athens. *Pleurisy. *Pneumonia. *Prion disease ...
Field, H., Young, P., Yob, J. M., Mills, J., Hall, L., Mackenzie, J. The natural history of Hendra and Nipah viruses. Microbes ... Australian encephalitis(英語:Murray Valley encephalitis virus) *MVEV(英語:Murray Valley encephalitis virus) ...
"Experimental Ebola drug 'remdesivir' may help protect against Nipah virus, say scientists". 3 June 2019.. ... It was developed by Gilead Sciences as a treatment for Ebola virus disease and Marburg virus infections, though it has ... Junin virus, Lassa fever virus, and MERS-coronavirus.[1] Remdesivir was rapidly pushed through clinical trials due to the 2013- ... It may also help protect against Nipah and Hendra virus infections.[9][10] ...
Nipah and Hendra viruses,[179][180] and possibly the ebola virus,[181][182] whose natural reservoir is yet unknown.[183][184] ... Scientists do not know where Ebola virus comes from.. *^ Rewar, Suresh; Mirdha, Dashrath (2015). "Transmission of Ebola Virus ... Brüssow, H. (2012). "On Viruses, Bats and Men: A Natural History of Food-Borne Viral Infections". Viruses: Essential Agents of ... "Hendra and Nipah viruses: different and dangerous". Nature Reviews Microbiology. 4 (1): 23-35. doi:10.1038/nrmicro1323. PMC ...
Wabak virus Nipah di Malaysia. 1998-1999. Al-Ma'unah. 2000. Peristiwa Kampung Medan. 2001. ...
Nipah virus infection Nipah virus (NiV) bats, pigs direct contact with infected bats, infected pigs ... Eastern equine encephalitis virus, Venezuelan equine encephalitis virus, Western equine encephalitis virus horses, donkeys, ... Kyasanur Forest disease virus rodents, shrews, bats, monkeys tick bite La Crosse encephalitis La Crosse virus chipmunks, tree ... Barmah Forest virus kangaroos, wallabies, opossums mosquito bite Bird flu Influenza A virus subtype H5N1 wild birds, ...
Field H, Young P, Yob JM, Mills J, Hall L, Mackenzie J (2001). "The natural history of Hendra and Nipah viruses". Microbes and ... Eastern equine encephalitis virus, Venezuelan equine encephalitis virus, Western equine encephalitis virus. horses, donkeys, ... Saint Louis encephalitis virus. birds. mosquito bite. Swine influenza. any strain of the influenza virus endemic in pigs ( ... An example of this is the outbreak of Nipah virus in peninsular Malaysia in 1999, when intensive pig farming began on the ...
"Experimental Ebola drug 'remdesivir' may help protect against Nipah virus, say scientists". Times Now Digital. 3 Haziran 2019. ... İlaç, SARS-CoV-2 ile Nipah ve Hendra virüs enfeksiyonlarında kullanımı için araştırma altındadır.[4][5][6] Diğer koronavirüs ... "Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys". Nature. 531 (7594). Mart 2016. ss. ... Nipah virüsü, Hendra virüsü ve koronavirüslerin de (MERS ve SARS virüsleri dahil) yer aldığı diğer tek sarmallı RNA virüslerine ...
A 2014 study of the Indian flying fox and Nipah virus found that while Nipah virus outbreaks are more likely in areas preferred ... Flying foxes are also reservoirs of henipaviruses such as Hendra virus and Nipah virus. Hendra virus was first identified in ... Nipah virus was first identified in 1998 in Malaysia. Since 1998, there have been several Nipah outbreaks in Malaysia, ... Flying foxes can transmit several non-lethal diseases as well, such as Menangle virus and Nelson Bay virus. These viruses ...
... especially in the discovery of the Nipah virus (1998-1999 Malaysia Nipah virus outbreak). The faculty is widely regarded as the ... "A Taste For Pork Helped A Deadly Virus Jump To Humans". NPR.org. "Nipah virus at 20". www.virology.ws. "QS Ranking". "History ... Chua Kaw Beng - Discovered the Nipah virus Emeritus Professor Dato' Dr. Goh Khean Lee - Recipient of the Merdeka Award, pioneer ... Nipah Virus Encephalitis Investigation Team from the Faculty of Medicine, University of Malaya In 2020, Subashan Vadibeler, a ...
"Hendra and Nipah Virus". Animal Viruses: Molecular Biology. Caister Academic Press. ISBN 978-1-904455-22-6. "Nipah yet to be ... Bonaparte, M; Dimitrov, A; Bossart, K (2005). "Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus". ... As all mononegaviral genomes, Hendra virus and Nipah virus genomes are non-segmented, single-stranded negative-sense RNA. Both ... Hyatt AD, Zaki SR, Goldsmith CS, Wise TG, Hengstberger SG (2001). "Ultrastructure of Hendra virus and Nipah virus within ...
2008). "Hendra and Nipah Virus". Animal Viruses: Molecular Biology. Caister Academic Press. p. 202. ISBN 978-1-904455-22-6. ... The chain of contagion involving bats and pigs is reminiscent of the trail of the Nipah virus (which infects cells in the ... Scientists determine the virus is spread by respiratory droplets and fomites, with an R0 of four when the virus mutates; they ... Ally Hextall determines the virus is a combination of genetic material from pig and bat-borne viruses. Scientists are unable to ...
... human respiratory syncytial virus, measles virus, mumps virus, Nipah virus, and rabies virus. All of these viruses cause ... Virus Taxonomy-Seventh Report of the International Committee on Taxonomy of Viruses, San Diego, USA: Academic Press, pp. 525- ... Virus Taxonomy-Eighth Report of the International Committee on Taxonomy of Viruses, San Diego, USA: Elsevier/Academic Press, pp ... Virus Taxonomy-Ninth Report of the International Committee on Taxonomy of Viruses, London, UK: Elsevier/Academic Press, pp. 653 ...
Nipah virus, and avian influenza). Many residents have also worked to reduce the burden of non-communicable diseases, such as ...
"A resurgence of the Nipah virus?". Health Issues India. Retrieved February 28, 2020. "Deadly Nipah virus outbreak hits southern ... "a bellwether of that potential risk of a Nipah pandemic". He warned of a potential epidemic of nipah virus, and stated at the ... "Nipah Outbreak Death Toll Increases To 16; Researchers Warn Of Potential For Virus's Further Spread". The Henry J. Kaiser ... nipah virus in Bangladesh, MERS in the Middle East and Republic of Korea, Ebola in Western Africa, Zika in Brazil, yellow fever ...
"Nipah virus: Dr Kafeel Khan's offer welcomed". Deccan Chronicle. 23 May 2018. Retrieved 19 July 2020. "Dr Kafeel Khan Walks Out ... In March 2018, Khan volunteered to provide medical assistance during the outbreak of the Nipah virus in Kozkhikode district in ...
Fruit bats in particular serve as the reservoir host for Nipah virus (NiV). Rats are known to be the reservoir hosts for a ... Lyssaviruses (including the Rabies virus), Henipaviruses, Menangle and Tioman viruses, SARS-CoV-Like Viruses, and Ebola viruses ... Viruses of the taxon Ebolavirus, which causes Ebola virus disease, are thought to have a natural reservoir in bats or other ... Luby, Stephen P.; Gurley, Emily S.; Hossain, M. Jahangir (2012). TRANSMISSION OF HUMAN INFECTION WITH NIPAH VIRUS. National ...
Mott, Meghan; NIAAA (2013-05-13). "The Perils of Nipah Virus and Ischemic Stroke". NIH Intramural Research Program. Retrieved ... Here, she focused on the pathogenesis of and countermeasures against Nipah virus, the Middle East Respiratory Syndrome ... for her research on modeling the transmission cycle of the deadly Nipah virus. From 2014 to 2015, de Wit spent 4 months in a ... Her dissertation was titled Molecular determinants of influenza A virus replication and pathogenesis. In 2009, de Wit moved to ...
Nipah virus is a causative agent of outbreaks of encephalitis with pneumonia and has a high case fatality rate. The first ... In a study published in the Scientific Reports, Syrian hamster model for Nipah virus infection was used, which closely mirrors ... In experiments in animals favipiravir has shown activity against West Nile virus, yellow fever virus, foot-and-mouth disease ... "Nipah virus disease: A rare and intractable disease". Intractable & Rare Diseases Research. 8 (1): 1-8. doi:10.5582/irdr. ...
"Nipah virus contained, last two positive cases have recovered: Kerala Health Min". The News Minute. 2018-06-11. Retrieved 2020- ... "Lessons from the Nipah virus outbreak in Malaysia" (PDF). The Malaysian Journal of Pathology. Department of Pathology, ... "Ebola Virus Disease Outbreak Uganda Situation Reports". WHO , Regional Office for Africa. Archived from the original on 20 June ... Vietnam on alert as common virus kills 81 children - Yahoo News Archived 2016-03-05 at the Wayback Machine. News.yahoo.com ( ...
Since it is very sweet, the Nipah virus carrier bats love to drink date sap. So Nipah virus can spread through this raw date ... from Nipah virus) need to need a certain amount of precaution. Some others famous foods from it are Palm sugar, Pitha, Date ...
Genus Henipavirus, mit Species Nipah-Virus, sowie Hendravirus. *Genus Jeilongvirus. *Genus Morbillivirus, mit Species ... Usutu-Virus - en. Usutu virus (USUV), Zika-Virus - en. Zika virus (ZIKV), sowie Gelbfieber-Virus - en. Yellow fever virus (YFV) ... Genus ‚Negevirus', mit Species ‚Blackford virus', ‚Bofa virus', ‚Buckhurst virus', ‚Marsac virus', sowie ‚Muthill virus'[53] ... Sorghum mosaic virus (SrMV), Lily-Mottle-Virus - en. Lily mottle virus (LMoV), sowie Sellerie-Virus Y - en. Apium virus Y (ApVY ...
Talk:2018 Nipah virus outbreak in Kerala. *Talk:3076 virus. *Talk:3099 virus ... Pages in category "Low-importance virus articles". The following 200 pages are in this category, out of approximately 1,493 ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Category:Low-importance_virus_articles&oldid=388350164" ...
2018 Nipah virus outbreak Nipah virus infection 1,743 (as of 21 July 2019[update]) Democratic Republic of the Congo & Uganda ... 2015-16 Zika virus epidemic Zika virus. Hundreds (as of 1 April 2016[update]) Africa 2016 2016 yellow fever outbreak in Angola ... Vietnam on alert as common virus kills 81 children - Yahoo News. News.yahoo.com (2011-08-19). Retrieved on 2014-05-12. ... Influenza A virus subtype H1N1 [117][118][119]. worldwide 2015-present ...
en:Nipah virus infection (19). *en:Nitazoxanide (11). *en:Non-small-cell lung carcinoma (10) ...
Kerala Nipah virus (2018). *Équateur province Ebola (2018). *Kivu Ebola (2018-2020) ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... Further information: Influenza A virus subtype H7N9. Influenza A virus subtype H7N9 is a novel avian influenza virus first ... DNA virus. Human polyomavirus 2 Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis ...
"Death toll from India's Nipah virus outbreak rises to 12 - Xinhua , English.news.cnDeath toll from India's Nipah virus outbreak ... DNA virus: HBV (B). RNA virus: CBV · HAV (A) · HCV (C) · HDV (D) · HEV (E) · HGV (G) ... "Nipah virus outbreaks in the WHO South-East Asia Region"। South-East Asia Regional Office। WHO। সংগ্রহের তারিখ ২৩ মে ২০১৮।. ... "WHO Nipah Virus (NiV) Infection"। www.who.int। ১৮ এপ্রিল ২০১৮ তারিখে মূল থেকে আর্কাইভ করা। সংগ্রহের তারিখ ২১ মে ২০১৮।. ...
Marburg virus disease. *Middle East respiratory syndrome coronavirus. *Nipah virus infection. *Rift Valley fever ... The immunization was called vaccination because it was derived from a virus affecting cows (Latin: vacca 'cow').[5][7] Smallpox ... Liesegang TJ (August 2009). "Varicella zoster virus vaccines: effective, but concerns linger". Canadian Journal of ... is the injection of the variola virus taken from a pustule or scab of a smallpox sufferer into the superficial layers of the ...
Nipah virus infection Nipah virus Norovirus (children and babies) Norovirus (New) Variant Creutzfeldt-Jakob disease (vCJD, ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV Lymphocytic ... Human parainfluenza virus infection Human parainfluenza viruses (HPIV) Hymenolepiasis Hymenolepis nana and Hymenolepis diminuta ...
Since the Nipah virus outbreak in 1999, the Malaysian Health Ministry have put in place processes to be better prepared to ... The 1977 virus was similar to other A/H1N1 viruses that had circulated prior to 1957. The virus was included in the 1978-79 ... Even though such viruses might theoretically develop into pandemic viruses, in Phase 1 no viruses circulating among animals ... Physical characteristics of influenza A viruses. UMN CIDRAP.. *^ "Flu viruses 'can live for decades' on ice". The New Zealand ...
Nipah virus disease is a disease caused by a dangerous virus. This virus belongs to the Paramyxoviridae family and causes ... The symptoms start to appear within 3-14 days of Nipah virus infection. When people first get Nipah virus infection, it looks ... The virus is not known to transmit through air. Detection[change , change source]. Nipah virus can be detected from throat ... Nipah virus is transmitted by fruit eating bats. The bats may transmit the virus to other animals, such as pigs. Humans can be ...
... and nipah virus[73] have emerged. Despite scientists' achievements over the past one hundred years, viruses continue to pose ... The virus was later shown to be a previously unrecognised herpes virus, which is now called Epstein-Barr virus.[55] ... The importance of tobacco mosaic virus in the history of viruses cannot be overstated. It was the first virus to be discovered ... Epstein-Barr virus is important in the history of viruses for being the first virus shown to cause cancer in humans.[57] ...
Her first frontline experience with infectious diseases were when the Nipah virus infected Singapore in 1999. In 2002 Leo was ... She has also been in charge of Singapore's response to several outbreaks, including Nipah, SARS and COVID-19. In 2020, she was ... She has led the country through Middle East respiratory syndrome (MERS), Influenza A virus subtype H7N9 (bird flu) and Dengue ... "A breakout star in battle against virus outbreaks". AsiaOne. Retrieved 2020-12-01. "Why Singapore will overcome Covid-19 even ...
Nipah virus infection can be prevented by avoiding exposure to sick pigs and bats in areas where the virus is present, and not ... Nipah virus (NiV) is a zoonotic virus, meaning that it can spread between animals and people. Fruit bats, also called flying ... Nipah virus is also known to cause illness in pigs and people. Infection with NiV is associated with encephalitis (swelling of ...
Nipah virus (NiV) infection can be diagnosed during illness or after recovery. Different tests are available to diagnose NiV ... NiV should be considered for people with symptoms consistent with NiV infection who have been in areas where Nipah is more ...
... now called Nipah virus, killed more than 100 people and infected thousands of pigs in Malaysia. Our scientists were part of the ... international task force to tackle the virus and have since participated in research to better understand the virus and to help ... In 1998-99 an outbreak of a disease caused by a new virus, ... Fighting Nipah virus. In 1998-99 an outbreak of a disease ... Nipah virus is a paramyxovirus and is very closely related to Hendra virus. It was named after one of the Malaysian villages ...
... now called the Nipah virus, killed more than 100 people and thousands of pigs in Malaysia. Our scientists were part of the ... international task force to tackle the virus and later participated in vaccine evaluation. ... An outbreak of Nipah virus also occurred in India in 2001. In total, more than 250 people have died from Nipah virus infection. ... Nipah virus is a new member of the paramyxovirus family and is closely related to the Hendra virus. It was named after one of ...
Learn about Nipah virus infection (NiV), a zoonotic disease that pigs and fruit bats can transmit to humans. NiV symptoms and ... home/infectious disease health center/infectious disease a-z list/nipah virus infection center /nipah virus infection article ... Nipah virus (NiV) is a member of the family Paramyxoviridae, genus Henipavirus and is related to Hendra virus that infects ... Nipah Virus Infection (NiV) Symptom. Encephalitis. *Encephalitis is a rare condition that is most often caused by viruses. ...
Nipah virus, scientific name Nipah henipavirus, is a bat-borne virus that causes Nipah virus infection in humans and other ... Viruses portal 1998-1999 Malaysia Nipah virus outbreak 2018 Nipah virus outbreak in Kerala Aditi, M. Shariff (2019). "Nipah ... the source of the human case from which Nipah virus was first isolated. Nipah virus is one of several viruses identified by WHO ... Numerous disease outbreaks caused by Nipah virus have occurred in South and Southeast Asia. Nipah virus belongs to the genus ...
As with Hendra virus, Nipah virus induced syncytial cells in vascular tissues and they were primarily vasotropic and/or ... A rapid immune plaque assay for the detection of Hendra and Nipah viruses and anti-virus antibodies. Journal of Virological ... Rapid immune plaque assays have been developed to quantify Nipah virus and detect neutralizing antibodies to the virus. A ... localization of the virus in pigs tended to be in respiratory epithelium rather than in neurons (Hooper, 2001). Nipah virus in ...
Virus stocks were grown in Vero cells, and the virus used was the fifth passage on Vero cells after isolation. The virus titer ... Establishment of a Nipah virus rescue system. Misako Yoneda, Vanessa Guillaume, Fusako Ikeda, Yuki Sakuma, Hiroki Sato, T. ... Establishment of a Nipah virus rescue system. Misako Yoneda, Vanessa Guillaume, Fusako Ikeda, Yuki Sakuma, Hiroki Sato, T. ... and Nipah viruses, belong to the negative and single-stranded nonsegmented RNA viruses, the mechanisms for the severe ...
Virus Hunters: Epidemiology of Nipah Virus. This is a part of Virus Hunter: Monitoring Nipah Virus in Bat Populations ... Virus Hunters: Epidemiology of Nipah Virus In this activity, students will be exploring cases of Nipah virus (NiV) infection as ... Virus Hunter: Monitoring Nipah Virus in Bat Populations In this video we follow scientists working in Bangladesh as they test ... analyzing real data from an outbreak of Nipah virus in Malaysia, attempting to identify the reservoir of the virus and curtail ...
The Nipah virus (NiV) is a type of RNA virus in the genus Henipavirus. The virus normally circulates among specific types of ... A Nipah virus infection is a viral infection caused by the Nipah virus. Symptoms from infection vary from none to fever, cough ... How the Nipah virus spreads Fruit bats are the natural reservoirs of Nipah virus During acute and convalescent stages of the ... Nipah virus outbreaks have been reported in Malaysia, Singapore, Bangladesh and India. The highest mortality due to Nipah virus ...
... called NIPRAB that shows robust immunization against Nipah virus in animal models and may be effective against other viruses in ... PHILADELPHIA -- Nipah virus is a type of RNA virus transmitted from animals to humans. The infection causes severe respiratory ... Those antibodies also react to a virus from the same family as Nipah, the Hendra virus, which causes similar symptoms. ... and incorporated a gene from Nipah virus - creating a viral particle that displays components of both viruses on its surface. ...
... following the confirmation of a Nipah virus case. Many people are under observation. Nipah is a potentially fatal viral disease ... There is no specific treatment and no vaccine for Nipah virus. To prevent illness, avoid contact with sick people, infected ...
Nipah virus has so far claimed 10 lives in Kozhikode and Malappuram districts in north Kerala while the condition of two ... Nipah virus (NiV) infection is a newly emerging zoonosis that causes severe disease in both animals and humans. The natural ... THIRUVANANTHAPURAM: A letter written by a Keralite nurse minutes before she died of the Nipah virus has gone viral in the ... Nipah-affected nurses letter from deathbed goes viral. Twenty eight-year-old Lini working in the Perambra Taluk Hospital in ...
... the disease resurfaced in the state with a 23-year-old student here confirmed to be infected with the potentially deadly virus ... A year after two north Kerala districts were hit by Nipah claiming 17 lives, ... Kerala govt confirms Nipah virus, 311 under observation. Kerala govt confirms Nipah virus, 311 under observation. Source : SIFY ... Nipah virus can be transmitted to humans from animals (such as bats or pigs), or contaminated foods and can also be transmitted ...
Tests point to the Nipah virus, which debuted during a devastating outbreak in Malaysia in 1999. ...
The deadly brain-damaging Nipah virus has resurfaced in Kerala a year after it killed 17 people, state officials said on ... NEW DELHI (Reuters) - The deadly brain-damaging Nipah virus has resurfaced in Kerala a year after it killed 17 people, state ... The virus was first identified in 1999 during an outbreak of illness affecting pig farmers and others in close contact with ... Nipah is on the WHOs research and development "priority pathogen" list alongside Ebola, Zika, MERS, Lassa and Crimean-Congo ...
NIH GARD Information: Nipah virus encephalitis. This information is provided by the National Institutes of Health (NIH) Genetic ... Home / For Patients and Families / Rare Disease Information / NIH GARD Report: Nipah virus encephalitis ...
Adapted from Nipah virus distribution map, Centers for Disease Control and Prevention (www.cdc.gov/vhf/nipah/outbreaks/ ... Nipah Virus Infection. Brenda S. P. Ang, Tchoyoson C. C. Lim, Linfa Wang ... Adapted from WHO data (http://www.searo.who.int/entity/emerging_diseases/links/nipah_virus_outbreaks_sear/en/). ...
Hendra virus and Nipah virus are highly pathogenic paramyxoviruses that have recently emerged from flying foxes to cause ... Hendra virus and Nipah virus are highly pathogenic paramyxoviruses that have recently emerged from flying foxes to cause ... Hendra and Nipah viruses: different and dangerous Nat Rev Microbiol. 2006 Jan;4(1):23-35. doi: 10.1038/nrmicro1323. ...
Occasionally the virus is introduced into human populations and causes severe illness characterized by encephalitis or ... Nipah virus (NiV) is a paramyxovirus whose reservoir host is fruit bats of the genus Pteropus. ... Nipah virus (NiV) is a paramyxovirus whose reservoir host is fruit bats of the genus Pteropus. Occasionally the virus is ... Transmission of human infection with Nipah virus Clin Infect Dis. 2009 Dec 1;49(11):1743-8. doi: 10.1086/647951. ...
The deadly brain-damaging Nipah virus has resurfaced in the southern Indian state of Kerala a year after it killed 17 people, ... NEW DELHI (Reuters) - The deadly brain-damaging Nipah virus has resurfaced in the southern Indian state of Kerala a year after ... who lost his battle against the brain-damaging Nipah virus, during his funeral at a burial ground in Kozhikode, in the southern ... The virus was first identified in 1999 during an outbreak of illness affecting pig farmers and others in close contact with ...
The discovery could allow scientists to develop more effective vaccines and rule out many approaches to fighting these viruses. ... The deadly Nipah virus and others like it assemble themselves in a much more haphazard manner than previously thought, new UBC ... Nipah is an example of an "enveloped" virus, which gets its outer wrapping from the infected host cell, much like the viruses ... The deadly Nipah virus and others like it assemble themselves in a much more haphazard manner than previously thought, new UBC ...
In the wake of deaths of several people in Kerala in the past fortnight due to Nipah virus, the state health department has ... Nipah virus has now hit Kerala. In the wake of deaths of several people in Kerala in the past fortnight due to Nipah virus, ... Nipah virus has now hit Kerala. In the wake of deaths of several people in Kerala in the past fortnight due to Nipah virus, ... Here are the latest developments in Nipah virus infection in India:. • The Nipah virus has so far claimed 11 lives in Kerala, ...
Nipah virus infection gets its name from the village in Malaysia where the person from whom the virus was first isolated ... What is Nipah Virus?. What is Nipah Virus?. Nipah virus infection gets its name from the village in Malaysia where the person ... Nipah virus infection gets its name from the village in Malaysia where the person from whom the virus was first isolated ... The organism which causes Nipah Virus encephalitis is an RNA or Ribonucleic acid virus of the family Paramyxoviridae, genus ...
Ten people there have died after being infected with the Nipah virus, a disease thought to be spread by fruit bats and other ...
Nipah virus, caused by the fruit bats, or the flying foxes has caused widespread panic with the recent report of a 23 -year ... Home » Website » Society » What Is Nipah Virus? Can It Be Cured?. What Is Nipah Virus? Can It Be Cured?. Nipah virus, caused by ... Can Nipah Virus Be Prevented?. Currently, there is no such vaccine yet to prevent the occurrence of Nipah virus. Based on the ... The Nipah virus spreads through fruit bats, also referred to as flying foxes. The virus is mostly present in the bat urine, ...
In this study, we used real time PCR to screen the saliva and urine of P. vampyrus from North Sumatera for Nipah virus genome. ... This is the first report of Nipah virus detection in P. vampyrus in Sumatera, Indonesia. ... Nipah virus causes periodic livestock and human disease with high case fatality rate, and consequent major economic, social and ... Nipah virus Is the Subject Area "Nipah virus" applicable to this article? Yes. No. ...
... brain-damaging virus has killed at least 10 people in southern India, where medical crews are scrambling to manage the spread ... Foreign Media On Nipah Virus That Has Killed 10 In Kerala. The virus has a mortality rate of 75 percent, according to the World ... The Nipah virus was first identified in 1999, after farmers and others who had come in contact with infected pigs in Malaysia ... Nipah Virus Alert In Madhya Pradeshs Guna, Gwalior; Advisories Issued. *Kerala, Goa Following Protocol To Control Spread Of ...
Fruit bats were the source of Nipah virus which created havoc in Keralas Kozhikode in May according to the Indian Council of ... Fruit Bats Identified As Source Of Nipah Virus Outbreak In Kerala. The second set of tests done on 55 fruit bats from Kozhikode ... Fruit bats were the source of Nipah virus which created havoc in Keralas Kozhikode in May according to the Indian Council of ... At least 13 people died and over 2,000 were kept under observation when Nipah virus struck in May. ...
  • These cases were initially diagnosed as Japanese encephalitis (JE), a virus which causes neurological symptoms in humans. (www.csiro.au)
  • Encephalitis (brain inflammation), nerve disorders, and respiratory problems are the major symptoms of Nipah virus infection. (medicinenet.com)
  • Encephalitis is a rare condition that is most often caused by viruses. (medicinenet.com)
  • The leading cause of severe encephalitis is the herpes simplex virus. (medicinenet.com)
  • Encephalitis, inflammation of the brain, is a potentially fatal complication of Nipah virus infection. (wikipedia.org)
  • There is no vaccine for the virus which can cause encephalitis, or inflammation of the brain, according to the World Health Organization (WHO). (reuters.com)
  • Occasionally the virus is introduced into human populations and causes severe illness characterized by encephalitis or respiratory disease. (nih.gov)
  • Nipah virus (NiV) infection is a disease associated with encephalitis, also known as inflammation of the brain. (financialexpress.com)
  • The organism which causes Nipah Virus encephalitis is an RNA or Ribonucleic acid virus of the family Paramyxoviridae, genus Henipavirus, and is closely related to Hendra virus. (indianexpress.com)
  • These viruses cause some of the world's deadliest diseases, such as AIDS, Nipah virus encephalitis, Ebola, hemorrhagic fever and Rift Valley fever. (medindia.net)
  • Belonging to the Henipavirus genus, this virus can cause fever, encephalitis and respiratory disorders. (medworm.com)
  • Nipah manifests with flu-like symptoms and can cause encephalitis - inflammation of the brain - which can lead to brain damage and death. (rt.com)
  • And the Nipah virus, which causes fatal encephalitis in up to 70 percent of human cases, causes seasonal outbreaks in Asia with person-to-person transmission now becoming a primary mode of infection. (medindia.net)
  • There is no vaccination for the virus which induces flu-like symptoms that lead to an agonising encephalitis and coma. (punchng.com)
  • The virus was first discovered after an outbreak of encephalitis in pig farmers in Malaysia and Singapore with subsequent outbreaks in Bangladesh or India occurring almost annually. (medworm.com)
  • Risk Factors for Nipah Virus Encephalitis in Bangladesh1. (cambridge.org)
  • Nipah Virus-associated Encephalitis Outbreak, Siliguri, India. (cambridge.org)
  • It was all part of a new endeavor to get one step ahead of a virus that can kill up to 90% of those infected with a terrifying combination of encephalitis and pneumonia. (flutrackers.com)
  • UCLA scientists have discovered how the deadly Nipah virus infiltrates human cells to cause encephalitis. (bio-medicine.org)
  • In the Nipah virus epidemic, which began in October 1998, 258 people (mostly pig farm workers) developed encephalitis and 104 died. (pighealth.com)
  • India reported two outbreaks of Nipah virus encephalitis in the eastern state of West Bengal, bordering Bangladesh, in 2001 and 2007. (pediatriconcall.com)
  • Nipah virus affects the brain and can cause encephalitis (swelling of the brain) which can present with several days of fever, confusion disorientation and persistent drowsiness. (pediatriconcall.com)
  • Recent Nipah outbreaks have resulted in acute respiratory distress syndrome and encephalitis, person-to-person transmission, and greater than 75 percent case fatality rates among humans. (globenewswire.com)
  • The virus is known to cause respiratory illnesses such as pneumonia and encephalitis. (passporthealthusa.com)
  • Case-Control Study of Risk Factors for Human Infection with a New Zoonotic Paramyxovirus, Nipah Virus, during a 1998-1999 Outbreak of Severe Encephalitis in Malaysia. (biointeractive.org)
  • There is no vaccine for the virus, which is spread through body fluids and can cause encephalitis, or inflammation of the brain, the World Health Organization (WHO) says. (physiciansweekly.com)
  • Henipaviruses are emerging zoonotic viruses and causative agents of encephalitis in humans. (eur.nl)
  • Nipah virus (NiV) is an emerging zoonotic paramyxovirus that causes highly lethal henipavirus encephalitis in humans. (jci.org)
  • Nipah virus (NiV), of the family Paramyxoviridae , was isolated in 1999 in Malaysia from a human fatality in an outbreak of severe human encephalitis, when human infections were linked to transmission of the virus from pigs. (iastate.edu)
  • The 1999 outbreak of Nipah virus encephalitis in humans and pigs in Peninsular Malaysia ended with the evacuation of humans and culling of pigs in the epidemic area. (cdc.gov)
  • The cases were primarily assumed to be Japanese B Encephalitis and four patients were tested positive for the virus. (cureus.com)
  • the cholesterol-tagged peptides cross the blood brain barrier, and effectively prevent and treat in an established animal model what would otherwise be fatal Nipah virus encephalitis. (prolekare.cz)
  • In addition to acute infection, these viruses cause asymptomatic infection in up to 60% of exposed people, and may lead to late-onset disease or relapse of encephalitis years after initial infection [24] , as well as persistent or delayed neurological sequelae. (prolekare.cz)
  • Brain inflammation (encephalitis) due to the Nipah virus that infects pigs and people. (drugster.info)
  • Nipah virus caused a severe outbreak of viral encephalitis in Malaysia in 1998-1999. (drugster.info)
  • The main risk factor for Nipah virus encephalitis is recent contact with pigs. (drugster.info)
  • Nipah virus causes severe illness characterized by inflammation of the brain ( encephalitis ) or respiratory diseases. (drugster.info)
  • equine encephalitis equine encephalitis , infectious disease of horses caused by any of several viruses, four of which-the Eastern, Western, Venezuelan, and St. Louis viruses-can also infect humans. (thefreedictionary.com)
  • Although no specific treatment can destroy the virus once the disease has become established, many types of encephalitis can be prevented by immunization. (thefreedictionary.com)
  • Primary encephalitides include diseases that develop after penetration of the brain by neurotropic viruses (epidemic encephalitis, Russian spring-summer encephalitis, Semliki forest encephalitis, herpes encephalitis, and zoster encephalitis). (thefreedictionary.com)
  • Nipah virus among military personnel involved in pig culling during an outbreak of encephalitis in Malaysia, 1998-1999. (microbiologyresearch.org)
  • Nipah encephalitis, human - Bangladesh (02). (microbiologyresearch.org)
  • The Nipah virus infection was first recognised in a large outbreak of 265 suspected cases and 105 deaths - a fatality rate of 40 per cent - in peninsular Malaysia from September 1998 to April 1999.The virus was first isolated from an outbreak of fatal encephalitis cases in the village of Nipah in the late 90s during investigations for Japanese encephalitis. (echarcha.com)
  • NiV should be considered for people with symptoms consistent with NiV infection who have been in areas where Nipah is more common, such as Bangladesh or India-particularly if they have a known exposure. (cdc.gov)
  • There have been almost annual outbreaks of Nipah virus in Bangladesh since 2001, with neighbouring India reporting outbreaks in 2001, 2007, 2018 and 2019. (www.csiro.au)
  • An outbreak of Nipah virus also occurred in India in 2001. (www.csiro.au)
  • Fruit bats, living in vast areas extending from India to the western Pacific, were identified as the natural reservoir of the virus. (pnas.org)
  • FILE PHOTO: Doctors and relatives wearing protective gear carry the body of a victim, who lost his battle against the brain-damaging Nipah virus, during his funeral at a burial ground in Kozhikode, in the southern Indian state of Kerala, India, May 24, 2018. (reuters.com)
  • In 2018, only two out of 19 people infected by Nipah in India survived an outbreak. (eurekalert.org)
  • A rare, brain-damaging virus has killed at least 10 people in southern India, where medical crews are scrambling to manage the spread of the deadly disease - and to minimize panic. (ndtv.com)
  • The newest virus outbreak struck the tropical coast of Kerala, India this May. (internationalsos.com)
  • Nipah virus has caused disease outbreaks in several parts of the world including Malaysia, Bangladesh, Singapore and India. (wikipedia.org)
  • Presently, an outbreak of Nipah virus is ongoing in Kerala, India. (wikipedia.org)
  • Nipah outbreaks have occurred in Malaysia, Singapore, Bangladesh and India. (medindia.net)
  • The outbreak of Nipah virus, a deadly lung and brain disease currently spreading into rural India through sweet food and domestic animals. (medindia.net)
  • Nipah outbreak is an emerging zoonosis which had resulted in fatal deaths in Kerala, India. (medindia.net)
  • India is currently grappling with news of a new epidemic caused by Nipah virus . (rediff.com)
  • The death toll from an outbreak of the rare Nipah virus in southern India jumped to 10 Tuesday with more than 90 people quarantined to try to stem the spread of the disease, officials said. (punchng.com)
  • Nipah has killed more than 260 people in Malaysia, Bangladesh and India since 1998 and has a mortality rate of nearly 70 percent, according to the World Health Organisation. (punchng.com)
  • Outbreaks of Nipah virus occur almost annually in India and Bangladesh, but Pteropus bats can be found throughout the tropics and subtropics, and henipaviruses have been isolated from them in Central and South America, Asia, Oceania, and East Africa. (cdc.gov)
  • Nipah virus (NiV) which is a newly emerging zoonosis causing severe disease in both animals and humans is the new threat in India. (biospectrumasia.com)
  • While Malaysia has not experienced an outbreak since that first spillover, Nipah virus outbreaks were later recognized in India and Bangladesh beginning in 2001 and cause nearly annual outbreaks in Bangladesh. (ecohealthalliance.org)
  • In Bangladesh, Nipah virus is transmitted directly from bats to people via date palm sap, a sweet drink harvested and consumed across Bangladesh and in parts of India. (ecohealthalliance.org)
  • Nipah virus caused an outbreak in pig and humans in Malaysia and Singapore between 1998 and 1999 and has been the cause of recurrent outbreaks in Bangladesh and West Bengal, India since 2001. (pediatriconcall.com)
  • The U.S Centres for disease control and prevention (CDC) says that Nipah virus outbreaks occur almost yearly in Bangladesh and there have been many such in India. (pediatriconcall.com)
  • The Nipah virus is an emerging pathogen found in Southeast Asia, particularly Malaysia, Bangladesh and India. (healthcanal.com)
  • The current Nipah virus outbreak in India makes the development of a human vaccine an immediate need," said Dr. Joseph Caravalho, President and CEO of HJF. (globenewswire.com)
  • Nipah virus and Hendra virus emerged in the 1990s causing serious disease outbreaks in humans and livestock in Australia, Malaysia, Singapore, Bangladesh and India. (globenewswire.com)
  • There is currently an outbreak of Nipah in India in a new location, where the death toll has risen to 10 in India's southern state of Kerala. (globenewswire.com)
  • During the same timeframe as this Ebola outbreak, India has begun a battle against the Nipah virus. (passporthealthusa.com)
  • First identified in 1999 in Malaysia, Nipah virus is an emerging pathogen found primarily in Bangladesh and India. (medicalxpress.com)
  • Human-to-human transmission has been observed during Nipah virus outbreaks in Bangladesh and India. (sciencemag.org)
  • The recent Nipah virus outbreak in Kerala, India, involving 23 cases and 21 deaths ( 2 ), again stressed the urgent need to develop prophylactic and therapeutic countermeasures against Nipah virus. (sciencemag.org)
  • This apart, in order to control the spread of Nipah Virus , the Government of India is taking several steps while efforts are focused on surveillance and spreading awareness for risk assessment and management of the disease. (halifaxlive.com)
  • Kolkata (West Bengal) [India], Jun 10 (ANI): Union Minister of State for Health, Ashwini Choubey on Saturday said no new case of Nipah virus has been reported from anywhere in the country. (aninews.in)
  • India notified the Nipah virus cases to WHO under the International Health Regulations, IHR (2005). (who.int)
  • You must be aware of Nipah virus infection, the recent endemic in South India. (yashodahospitals.com)
  • Antibodies to Nipah virus have been found in fruit bats in India, Indonesia and Timor-Leste. (yashodahospitals.com)
  • While little is known about the Nipah virus in India, it is spreading fast in the region and has a reported mortality rate of 70 percent. (avivaindia.com)
  • An infectious disease outbreak of Nipah virus (NiV) in Kozhikode and Malappuram districts in Kerala (India) has left at least 17 people dead of 18 cases bringing the world's attention in May 2018. (alliedacademies.org)
  • The first reported outbreak of Nipah in India was in Siliguri in 2001, when 33 persons fell ill after exposure to patients. (echarcha.com)
  • People have also been infected with the virus from drinking palm sap that had attracted thirsty bats in Bangladesh and parts of India. (miragenews.com)
  • International SOS is currently monitoring the situation in Kerala closely, following the confirmation of a Nipah virus case. (internationalsos.com)
  • Nipah virus has so far claimed 10 lives in Kozhikode and Malappuram districts in north Kerala while the condition of two undergoing treatment is said to be critical. (indiatimes.com)
  • A year after two north Kerala districts were hit by Nipah claiming 17 lives, the disease resurfaced in the state with a 23-year-old student here confirmed to be infected with the potentially deadly virus. (sify.com)
  • Earlier, blood samples examined at two virology institutes--Manipal Institute of Virology and Kerala Institute of Virology and Infectious Diseases--had indicated Nipah. (sify.com)
  • NEW DELHI (Reuters) - The deadly brain-damaging Nipah virus has resurfaced in Kerala a year after it killed 17 people, state officials said on Tuesday. (reuters.com)
  • Kerala Health Minister K.K. Shailaja told reporters that four other people had Nipah-like symptoms. (reuters.com)
  • Nipah virus has now hit Kerala. (financialexpress.com)
  • In the wake of deaths of several people in Kerala in the past fortnight due to 'Nipah' virus, the state health department has been put on high alert. (financialexpress.com)
  • In a tweet, Union Health Minister Jagat Prakash Nadda today said, "Reviewed the situation of deaths related to Nipah virus in Kerala with Secretary Health. (financialexpress.com)
  • The Nipah virus has so far claimed 11 lives in Kerala, including three members of a family and eight others who showed similar symptoms in Kozhikode and Malappuram. (financialexpress.com)
  • According to updates from the Office of Chief Minister of Kerala, CM Pinarayi Vijayan has informed that the Government is closely monitoring the spread of the Nipah virus. (financialexpress.com)
  • Nipah virus, caused by the fruit bats, or the 'flying foxes' has caused widespread panic with the recent report of a 23 -year old youth having contracted the disease in Ernakulam district of Kerala. (outlookindia.com)
  • In 2018, Kerala witnessed a deadly outbreak of the nipah virus. (outlookindia.com)
  • A total of 19 Nipah virus (NiV) cases, including 17 deaths, were reported from Kerala State. (outlookindia.com)
  • Two others have tested positive for Nipah and are considered critically ill, and more than three dozen people have been put into quarantine since the outbreak began in Kerala, according to BBC News. (ndtv.com)
  • But the virus's spread - and the rapidly rising death toll - have prompted concern in the outbreak's epicenter, Kozhikode, a coastal city in Kerala, where people have been "swarming" hospitals with fevers and other illnesses to ensure they do not have the virus, a local government official told Reuters. (ndtv.com)
  • Gulf News reported that Kerala "is in a state of panic after many cases of the killer Nipah virus were detected. (ndtv.com)
  • WHO has been informed about Nipah virus cases being reported in a family from a village in Kozhikode district of Kerala," he said. (ndtv.com)
  • Even when the final green signal came from Kerala health authorities that the fear of the spread has been contained, the source of the virus outbreak was yet to be ascertained. (ndtv.com)
  • Health officials in the state of Kerala are on high alert after tests on animals thought to be carriers for the Nipah virus, including bats, cattle, goats and pigs, showed no sign of the disease. (rt.com)
  • With tests from other suspect deaths awaited, authorities in Kerala state have ordered emergency measures to control the virus, which is spread by fruit bats. (punchng.com)
  • Among the dead in the Kerala outbreak was nursing assistant and mother-of-two Lini Puthussery, who had helped to treat one of the original family suffering from Nipah. (punchng.com)
  • According to the reports, ten people have lost their lives to the Nipah virus in northern Kerala districts of Kozhikode and Malappuram. (biospectrumasia.com)
  • With so many number of cases already reported in Kerala, the virus is currently a major threat to human health. (biospectrumasia.com)
  • In view of the rising number of cases and reported deaths due to Nipah Virus in Kozhikode, Kerala, J P Nadda, Union Minister of Health and Family Welfare has assured all support to the Kerala Government and has directed a multi-disciplinary Central team from National Centre for Disease Control to immediately visit the district, and assist the State and closely monitor the situation. (biospectrumasia.com)
  • As per the statement given by KK Shylaja, health minister of Kerala, "10 deaths were due to the nipha virus and that the World Health Organisation (WHO) has been informed about the outbreak of the virus in Kerala. (biospectrumasia.com)
  • Talking about the current situation of the disease in state, Pinarayi Vijayan, Chief Minister of Kerala said, "The state government was taking all steps to control Nipah virus. (biospectrumasia.com)
  • The Union Minister for Health & Family Welfare, J P Nadda is closely monitoring the situation arising out of reported cases and deaths due to Nipah Virus in Kerala. (biospectrumasia.com)
  • The number of deaths from the contagious Nipah virus infection in Kerala may have touched 14 with two more reported on Tuesday even as state and central health agencies stepped up efforts to contain the spread of the deadly virus. (hindustantimes.com)
  • Both patients are from Kerala and one of them had recently met with one of the people infected with Nipah virus in Kerala, according to reports from Mangaluru. (hindustantimes.com)
  • Kerala CM Pinarayi Vijayan on Monday said although Nipah-related deaths have been reported only in Kozhikode, the entire state has been put on alert, and private hospitals have been asked to not deny treatment to any patient with suspected symptoms. (indianexpress.com)
  • Kerala Health Services director Dr R L Saritha said, "So far three cases have been virologically confirmed as caused by Nipah. (indianexpress.com)
  • The fluid samples of a jawan, who died here days after returning from his hometown in Kerala, has tested 'negative' for Nipah virus infection, a defence official said today. (financialexpress.com)
  • Thiruvananthapuram, May 23: Kerala Health Minister K.K. Shailaja on Wednesday said that the outbreak of Nipah virus (NiP), which has claimed 10 lives, has been contained and there was no need to panic. (sentinelassam.com)
  • Kerala Health Minister KK Shailaja who has been leading from the front, the state's fightback against the virus said no new cases have been reported in the state. (indiatimes.com)
  • Union Health Minister Harsh Vardhan who is also monitoring the situation in the state confirmed that no new case of Nipah virus infection has been reported in Kerala. (indiatimes.com)
  • Kerala Health Minister said the state was able to act in such swift manner as they were anticipating the relapse of the deadly virus. (indiatimes.com)
  • Last year, the virus killed 17 people in Kerala. (passporthealthusa.com)
  • DUBAI/MUMBAI (Reuters) - The United Arab Emirates (UAE) has banned imports of fresh vegetables and fruits from the southern Indian state of Kerala where 13 people have died due to an outbreak of the rare brain-damaging Nipah virus, the Gulf state said on Tuesday. (physiciansweekly.com)
  • As many as 16 people lost their lives in Kerala due to the outbreak of the virus in May. (aninews.in)
  • Nipah virus infection is a severe endemic that has recently hit the city, Kochikode, Kerala. (yashodahospitals.com)
  • Though, the disease may not be an immediate threat for states other than Kerala, it is still important for us all to be aware about the ways to prevent and manage Nipah virus infections and its symptoms. (yashodahospitals.com)
  • The current endemic in Kerala is an infectious sequel of similarly serious Nipah outbreaks in several districts of West Bengal from 2001 to 2008. (yashodahospitals.com)
  • The Kerala health department is on a high alert as the deadly Nipah virus has caused a public health scare. (avivaindia.com)
  • Scientists have launched a multi-agency effort to contain the Nipah virus outbreak in Kerala, which has claimed six lives so far, including that of two brothers and a nursing assistant who treated them, officials told The Indian Express. (echarcha.com)
  • Scientists at AAHL are also studying bat ecology and the bat immune system to determine how viruses, such as Nipah or 2019-nCoV (which is causing an ongoing crisis), maintain themselves in bats and how the viruses 'spill over' into other animals and humans. (www.csiro.au)
  • Scientists at AAHL are studying bat ecology and the bat immune system to determine how viruses, such as Nipah, maintain themselves in bats and how they 'spill over' into other animals and humans. (www.csiro.au)
  • Nipah virus infection is a zoonosis transferred by contact with an NiV-infected animal or person or their secretions that has a high fatality rate in infected humans. (medicinenet.com)
  • The risk factors for this infection include having close contact with infected animals such as pigs, bats, and/or humans infected with the virus. (medicinenet.com)
  • Nipah virus, scientific name Nipah henipavirus, is a bat-borne virus that causes Nipah virus infection in humans and other animals, a disease with a high mortality rate. (wikipedia.org)
  • Later outbreaks have caused respiratory illness in humans, increasing the likelihood of human-to-human transmission and indicating the existence of more dangerous strains of the virus. (wikipedia.org)
  • Hendra virus affected 21 horses and two humans in Brisbane, Australia with 14 horses and one human dying as a result ( Hooper et al. (cabi.org)
  • The new virus was named Nipah and was confirmed by molecular characterization to be the agent responsible for the disease in both humans and pigs. (cabi.org)
  • Nipah virus (NiV), a paramyxovirus, was first discovered in Malaysia in 1998 in an outbreak of infection in pigs and humans and incurred a high fatality rate in humans. (pnas.org)
  • In 1998, the virus spread from fruit bats to pigs and then to humans. (pnas.org)
  • this has been used in monkeys to protect against Hendra virus, although its potential for use in humans has not been studied. (wikipedia.org)
  • PHILADELPHIA -- Nipah virus is a type of RNA virus transmitted from animals to humans. (eurekalert.org)
  • In order to reduce the risk of Nipah virus becoming a global danger, it's essential to develope a safe and effective vaccine against the virus for humans and animals. (eurekalert.org)
  • Nipah virus (NiV) infection is a newly emerging zoonosis that causes severe disease in both animals and humans. (indiatimes.com)
  • Nipah virus can be transmitted to humans from animals (such as bats or pigs), or contaminated foods and can also be transmitted directly from human-to-human. (sify.com)
  • According to the WHO, Nipah virus is a newly emerging disease that can be transmitted from its reservoir (natural wildlife host), the flying foxes (fruit bats), to both animals and humans. (sify.com)
  • A 23-year-old student tested positive for the virus, which is transmitted to humans through direct contact with infected bats, pigs or other people. (reuters.com)
  • Hendra virus and Nipah virus are highly pathogenic paramyxoviruses that have recently emerged from flying foxes to cause serious disease outbreaks in humans and livestock in Australia, Malaysia, Singapore and Bangladesh. (nih.gov)
  • Nipah can cause severe diseases and fatal brain swelling in both humans and animals. (eurekalert.org)
  • Nipah virus can be transmitted to humans by coming in close contact with these animals. (financialexpress.com)
  • Nipah Virus, which is a zoonotic disease, was known to affect humans in Malaysia and Singapore after coming in direct contact with the excretions or secretions of infected pigs. (indianexpress.com)
  • Due to the impact of the virus so far, combined with the lack of treatment, there is an apparent risk that further outbreaks will occur in humans, and that new locations may be affected. (internationalsos.com)
  • This virus belongs to the Paramyxoviridae family and causes severe disease in humans, where approximately half of all patients die. (wikipedia.org)
  • As of now, we know 582 cases of humans infected with Nipah virus, out of which approximately half died. (wikipedia.org)
  • Both viruses have a high fatality rate in humans more than 75 percent for Nipah and 60 percent for Hendra. (medindia.net)
  • Five of the 14 species of bats in Malaysia have been identified as carriers, and this virus affects horses, cats, dogs, pigs and humans. (medworm.com)
  • In Bangladesh in 2004, humans were infected with the virus after eating date palm sap that had been contaminated by infected fruit bats. (rt.com)
  • The detailed outbreak investigations carried out over the last decade by our colleagues from the icddr,b and IEDCR in Bangladesh have made it possible to answer key questions about the transmission of the virus between humans », states Simon Cauchemez, co-senior author of the study and head of the Mathematical Modelling of Infectious Diseases Unit at the Institut Pasteur. (eurekalert.org)
  • In 2004, humans became infected with Nipah after eating date palm sap contaminated by fruit bats. (punchng.com)
  • Publication date: Available online 26 February 2019Source: Microbes and InfectionAuthor(s): Nazia Thakur, Dalan BaileyAbstractNipah virus is an emerging zoonotic paramyxovirus that causes severe and often fatal respiratory and neurological disease in humans. (medworm.com)
  • As per the World Health Organisation (WHO), Nipah Virus is a newly emerging zoonosis that causes a severe disease in both animals and humans. (indiatimes.com)
  • The virus can be transferred through infected bats, pigs or humans who have been infected. (indiatimes.com)
  • In 2004, humans who consumed the date palm sap infected by fruit bats, caught the virus as well. (indiatimes.com)
  • RIRDC has been a lead player in successfully coordinating this multi-jurisdiction research program and the outcomes have increased our knowledge on how Hendra virus is spread and the impacts the disease has on both horses and humans," Mr Harvey said. (pearltrees.com)
  • Hendra virus (HeV), a potentially fatal zoonotic disease spread by flying foxes, to date has always infected humans via a spillover event from equine HeV infection. (pearltrees.com)
  • Nipah virus (NiV) is a zoonosis that can affect both humans and animals in severe ways . (organicfacts.net)
  • The virus is usually spread to humans from animals, contaminated food, or direct human-to-human transmission. (news-medical.net)
  • The Nipah surveillance system she helped establish in 2007 has provided scientists with 12 years of data on how the virus jumps from bats to humans and how it infects its hosts. (flutrackers.com)
  • Both viruses are zoonotic pathogens causing disease and death in domestic animals and humans. (pighealth.com)
  • Nipahvirus primarily affects pigs and humans, Hendravirus mainly infects horses and people. (pighealth.com)
  • Nipah Virus Infection (NiV) is a newly emerging infection acquired mainly form fruit bats which causes severe disease in humans and animals. (pediatriconcall.com)
  • When did Nipah virus first affect humans? (pediatriconcall.com)
  • How do humans acquire Nipah virus infection? (pediatriconcall.com)
  • There are no therapeutics for the virus and no vaccines for humans. (healthcanal.com)
  • The virus is carried by animals, typically fruit bats, and spreads to humans through contamination of food and water. (passporthealthusa.com)
  • The invention relates to virus-like particles of bacteriophage MS2 (MS2 VLPs) displaying peptide epitopes or peptide mimics of epitopes of Nipah Virus envelope glycoprotein that elicit an immune response against Nipah Virus upon vaccination of humans or animals. (osti.gov)
  • Recurrent Zoonotic Transmission of Nipah Virus into Humans, Bangladesh, 2001-2007. (biointeractive.org)
  • Nipah virus causes severe and often fatal respiratory and neurological disease in humans ( 1 ). (sciencemag.org)
  • Nipah virus (NiV) (Genus Henipavirus) is a recently emerged zoonotic virus that causes severe disease in humans and has been found in bats of the genus Pteropus. (unimas.my)
  • Nipah virus (NiV) is an emerging zoonotic paramyxovirus that causes severe and often fatal disease in pigs and humans. (sciencemag.org)
  • As per the World Health Organisation, Nipah virus , spread by fruit bats, causes communicable disease and is fatal for both animals and humans. (aninews.in)
  • Nipah virus infection is a newly emerged zoonosis (disease transmitted to humans from animals) affecting the south-east Asia. (yashodahospitals.com)
  • Scientists believe that the Nipah virus spreads to humans from animals (bat and pigs) through infected environmental contaminants such as infected fruits or raw date palm sap tapped directly from trees. (yashodahospitals.com)
  • An investigational subunit vaccine with cross-protective antibodies to Hendra (HENV) and Nipah (NIPV) viruses shows potential protection in humans. (yashodahospitals.com)
  • Though the drug Ribavirin is effective in the treatment of viruses in vitro, its clinical efficacy on humans is still unknown. (avivaindia.com)
  • Nipah virus infection is an example of zoonotic disease, where the disease can be transmitted from animals to humans. (avivaindia.com)
  • NiV and Hendra (HeV) viruses are emerging zoonotic paramyxoviruses [14] that are lethal to humans. (prolekare.cz)
  • Objective: To better understand the potential risks of Nipah virus emergence in Cambodia by studying different components of the interface between humans and bats.Methods: From 2012 to 2016, we conducted a study at two sites in Kandal and Battambang provinces where fruit bats (Pteropus lylei) roost. (cirad.fr)
  • We identified clear potential routes for virus transmission to humans through local practices, including fruit consumed by bats and harvested by humans when Nipah virus is circulating, and palm juice production. (cirad.fr)
  • Differences in agricultural practices among the regions where Nipah virus has emerged may explain the situation in Cambodia and point to actions to limit the risks of virus transmission to humans.Conclusion: Human practices are key to understanding transmission risks associated with emerging infectious diseases. (cirad.fr)
  • Nipah virus (NiV) is a zoonotic emerging pathogen that can cause severe and often fatal respiratory disease in humans. (microbiologyresearch.org)
  • As of May 2018 about 700 human cases of Nipah virus were estimated to have occurred, and 50 to 75 percent of those infected died. (wikipedia.org)
  • On May 19, 2018, Nipah virus disease (NiV) outbreak was reported from Kozhikode. (sify.com)
  • Bethesda, MD, May 24, 2018 (GLOBE NEWSWIRE) -- The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) today announced a license agreement of the vaccine for Nipah virus and Hendra virus from the Joint Technology Transfer Office of the Uniformed Services University (USU) and HJF. (globenewswire.com)
  • Available on http://www.who.int/csr/disease/nipah/en/ Accessed online on 22 May 2018. (yashodahospitals.com)
  • http://www.searo.who.int/entity/emerging_diseases/links/CDS_Nipah_Virus.pdf?ua=1Accessed online on 22 May 2018. (yashodahospitals.com)
  • August 21, 2018) The Killer Virus Called Nipah: A Review. (cureus.com)
  • Nipah virus infection can be prevented by avoiding exposure to sick pigs and bats in areas where the virus is present, and not drinking raw date palm sap which can be contaminated by an infected bat. (cdc.gov)
  • Research to understand more about zoonotic diseases is also being undertaken, with a focus on the interaction of bats and viruses and identifying and characterising new and emerging infectious agents such as 2019-nCoV. (www.csiro.au)
  • the virus often infects animals such as pigs and fruit bats ( Pteropodidae ), but they may be asymptomatic (not show any symptoms). (medicinenet.com)
  • Antibodies to henipaviruses have also been found in fruit bats in Madagascar (Pteropus rufus, Eidolon dupreanum) and Ghana (Eidolon helvum) indicating a wide geographic distribution of the viruses. (wikipedia.org)
  • Based on seroprevalence data and virus isolations, the primary reservoir for Nipah virus was identified as Pteropid fruit bats, including Pteropus vampyrus (large flying fox), and Pteropus hypomelanus (small flying fox), both found in Malaysia. (wikipedia.org)
  • Antibodies to the virus have also been found in fruit bats, horses, cats, and dogs. (cabi.org)
  • The virus normally circulates among specific types of fruit bats. (wikipedia.org)
  • How the Nipah virus spreads Fruit bats are the natural reservoirs of Nipah virus During acute and convalescent stages of the disease, RNA can be detected using reverse transcriptase polymerase chain reaction (RT-PCR) from throat swabs, cerebrospinal fluid, urine and blood analysis. (wikipedia.org)
  • Bats harbour a significantly higher proportion of zoonotic viruses than all other mammalian orders, and are known not to be affected by the many viruses they carry, apparently due to their developing special immune systems to deal with the stress of flying. (wikipedia.org)
  • The natural host of the virus are fruit bats of the Pteropodidae family, Pteropus genus. (indiatimes.com)
  • India's national health and wildlife ministries are working to test and identify bats with the virus, Health Minister Harsh Vardhan said in New Delhi. (reuters.com)
  • Nipah virus (NiV) is a paramyxovirus whose reservoir host is fruit bats of the genus Pteropus. (nih.gov)
  • It is being suspected that the virus is being spread by bats. (financialexpress.com)
  • The disease spreads through fruit bats or 'flying foxes,' of the genus Pteropus, who are natural reservoir hosts of the Nipah and Hendra viruses. (indianexpress.com)
  • Presumably, the first incidence of Nipah virus infection occurred when pigs in Malaysian farms came in contact with the bats who had lost their habitats due to deforestation. (indianexpress.com)
  • Ten people there have died after being infected with the Nipah virus, a disease thought to be spread by fruit bats and other animals. (theepochtimes.com)
  • The virus was first reported in Malaysia in the year 1999, when pigs in farms came in contact with the bats, who had lost their habitat due to deforestation. (outlookindia.com)
  • Nipah Virus: The outbreak is suspected to have been spread by infected fruit bats. (ndtv.com)
  • There is no clear preventive or curative treatment for Nipah, a newly emerging disease spread by bats, pigs and people who have become infected, according to the Centers for Disease Control and Prevention and the World Health Organization. (ndtv.com)
  • The second set of tests done on 55 fruit bats from Kozhikode confirmed that the nocturnal mammals were behind the Nipah spread. (ndtv.com)
  • Fruit bats were the source of Nipah virus which created havoc in Kerala's Kozhikode in May according to the Indian Council of Medical Research (ICMR), an official said on Tuesday. (ndtv.com)
  • Originally attributed to contact with sick pigs, the latest outbreak of the virus is being attributed to the transmittance from bats. (internationalsos.com)
  • The virus is commonly transmitted by fruit eating bats [1] . (wikipedia.org)
  • The bats may transmit the virus to other animals, such as pigs. (wikipedia.org)
  • In Bangladesh, people were affected by the virus when they drank date palm toddy which was contaminated by bats. (wikipedia.org)
  • Nipah Virus (NiV) or Hendra virus is a deadly virus that spreads via contact with the saliva, urine, or excreta of fruit bats or pigs. (medindia.net)
  • In addition to this, the natural reservoirs of this virus have been identified to be fruit bats from the genus Pteropus. (medworm.com)
  • Pigs were thought to be the intermediate host at the time, but the World Health Organization (WHO) found that fruit bats are the most natural host for the virus. (rt.com)
  • The virus, upon which the Hollywood blockbuster Contagion was modeled, is found naturally in several species of fruit bats. (drugs.com)
  • On that occasion, pigs were the virus hosts but they are believed to have caught it from bats. (punchng.com)
  • As quoted by the WHO, the natural host of the virus are fruit bats of the Pteropodidae Family, Pteropus genus. (indiatimes.com)
  • The natural reservoir for Hendra virus is believed to be flying foxes (bats of the genus Pteropus ) found in Australia. (cdc.gov)
  • Nipah virus is a virus that is carried out through fruit bats (family Pteropodidae , genus Pteropus ). (organicfacts.net)
  • First identified during an outbreak of disease that took place in Kampung Sungai Nipah, Malaysia in the year 1998, the natural hosts of the virus are fruit bats of Pteropodidae family. (biospectrumasia.com)
  • According to Dr Mahesh Kumar, the virus spreads by consuming infected fruits like mango and fresh date palm sap contaminated by bats and also by coming in direct contact with an infected patient and sometimes infected pigs. (biospectrumasia.com)
  • Kozhikode: Animal Husbandry department and forest officials collect bats from a well of a house after the outbreak of 'Nipah' virus, near Perambra in Kozhikode on Monday. (indianexpress.com)
  • Dr Saritha said it is suspected that Nipah virus was induced by fruit bats. (indianexpress.com)
  • An outbreak of the Nipah virus in northern Bangladesh has killed 30 people since the start of 2011, prompting national health warnings against the fatal pathogen spread by fruit bats. (goodplanet.info)
  • Giant fruit bats-which carry the virus and occasionally shed it, but are not affected by it-fed on mangoes in trees that overhung the pig pens and dropped bits of fruit contaminated with saliva, and occasionally nipah virus, into the pens where pigs were able to eat them. (ecohealthalliance.org)
  • People become infected when bats shedding Nipah virus contaminate the sap overnight with saliva or other excreta as they drink the sap. (ecohealthalliance.org)
  • As with the outbreak in Malaysia, Nipah makes its way from bats into people or livestock through the contamination of food that is shared by people and bats. (ecohealthalliance.org)
  • One of our research priorities is to study Nipah virus in bats to determine where and when they are most likely to shed virus which could lead to a human outbreak. (ecohealthalliance.org)
  • Natural wildlife hosts of Henipa viruses are Pteropid fruit bats (flying foxes). (pighealth.com)
  • The discovery of antibodies capable of neutralising the Hendra and Nipah viruses in African bats has overturned ideas about how the viruses spread. (australasianscience.com.au)
  • The virus is transmission can occur by direct contact with infected bats, pig or other people infected with the virus. (pediatriconcall.com)
  • The viruses are found naturally in several species of Pteropid fruit bats (flying foxes). (globenewswire.com)
  • Henipaviruses are considered to be bat viruses, found to be associated with bats from the families Pteropididae, Phystolomidae, and Mormoopidae. (dovepress.com)
  • 6 Experimentally or naturally infected bats, however, seroconvert and shed the virus in urine, saliva, and uterine fluid. (dovepress.com)
  • 6 - 10 There is a greater than 40% prevalence of antibodies to HeV in Australian pteropid bats 11 , 12 with viral RNA and infectious virus detected in urine samples collected under the roosting flying foxes, 10 and in free-living colonies of P. alecto (fetus) and P. poliocephalus (fetus and uterine fluid). (dovepress.com)
  • the reservoir status of the bats was confirmed by the detection of viral RNA or by virus isolation. (dovepress.com)
  • The ministry suspects that fruit bats are the source of the virus. (physiciansweekly.com)
  • Indian health officials have not been able to trace the origin of the Nipah outbreak and have begun a fresh round of tests on fruit bats from Perambra, the suspected epicenter of the infection. (physiciansweekly.com)
  • Broadly, the virus may thrive and spread through excretions such as saliva, urine and excreta of the infected bats. (yashodahospitals.com)
  • Infective virus easily spreads through bats and their excreta. (yashodahospitals.com)
  • The disease spreads through fruit bats, also called as Flying Foxes, who are natural reservoir hosts of Nipah virus. (avivaindia.com)
  • The virus has Pteropus bats as natural reservoir and other bat species from countries like Indonesia, Philippines, Thailand, Madagascar, Cambodia, and Ghana. (alliedacademies.org)
  • While WHO reports the risk of geographical spread of Nipah outbreaks to be low, the wide distribution and extensive migration of fruit bats species raise concerns about the pandemic of NiV with devastating zoonotic potential. (alliedacademies.org)
  • and Nipah virus circulation in bat and human populations (virus monitoring in bat urine and anti-Nipah-virus antibody detection in human serum).Findings : Our results confirmed circulation of Nipah virus in fruit bats (28 of 3930 urine samples positive by polymerase chain reaction testing). (cirad.fr)
  • Bats are believed to be the natural host of Nipah virus. (drugster.info)
  • The virus is similar but not identical to Hendra virus, another agent of zoonotic viral disease in which bats are the usual host. (drugster.info)
  • The virus naturally occurs in different species of fruit bats. (echarcha.com)
  • Although no related human diseases have been reported in Africa, henipavirus antibodies have been found there in both people and bats, an indication that the virus is circulating in this continent. (miragenews.com)
  • Flying fox bats are among the carriers of Nipah and Hendra viruses. (miragenews.com)
  • Among the chief carriers of Nipah virus and Hendra virus are large, fruit-eating bats, called flying foxes. (miragenews.com)
  • In Australia, horses have come down with Hendra virus after bats contaminated their food or water. (miragenews.com)
  • Nipah virus has been transmitted from bats to pigs in Malaysia and Singapore, and then from the pigs to farmers. (miragenews.com)
  • It was named after one of the Malaysian villages affected, Sungai Nipah, and was isolated by Dr Chua Kaw Bing from the University of Malaya in March 1999. (www.csiro.au)
  • The name "Nipah" refers to the place, Sungai Nipah in Port Dickson, Negeri Sembilan, the source of the human case from which Nipah virus was first isolated. (wikipedia.org)
  • The disease is named after a village in Malaysia, Sungai Nipah. (wikipedia.org)
  • The virus, named after a village in Malaysia, Sungai Nipah, is the site of the first known outbreak in 1998-99. (internationalsos.com)
  • But the virus, which gets its name from the place where it was first identified -- Kampung Sungai Nipah in Malaysia -- has no vaccine or effective treatment. (rediff.com)
  • NiV was first identified during an outbreak of disease that took place in Kampung Sungai Nipah, Malaysia in 1998. (rediff.com)
  • The causative agent was determined to be closely related to Hendra virus and was later named for the Malaysian village of Kampung Sungai Nipah. (cdc.gov)
  • It gets its name from a village in Malaysia, Kampung Sungai Nipah, where the disease was first identified in 1998. (organicfacts.net)
  • A senior scientist at NIV said, "Confirming a human infection with Nipah virus is a matter of concern but there is no need for panic because timely diagnosis and rapid mobilisation of Central and state health assets on ground should mitigate the spread. (indianexpress.com)
  • Eleven men were found to have acute infection with Nipah virus as indicated by IgM antibodies in their serum. (pighealth.com)
  • How to prevent infection with Nipah virus? (pediatriconcall.com)
  • Human infection with Nipah virus is often fatal, and there are no approved therapeutics. (sciencemag.org)
  • In 1998-99 an outbreak of a disease caused by a new virus, now called Nipah virus, killed more than 100 people and infected thousands of pigs in Malaysia. (www.csiro.au)
  • The first cases of Nipah virus infection were identified in 1998, when an outbreak of neurological and respiratory disease on pig farms in peninsular Malaysia caused 265 human cases, with 105 deaths. (wikipedia.org)
  • Nipah Virus is an emerging infectious disease that broke out in Malaysia and Singapore in 1998 and 1999. (indianexpress.com)
  • The virus emerged in 1998 during a large outbreak of infection and disease among pigs and pig farmers in Southeast Asia. (medindia.net)
  • Nipah first appeared in Malaysia in 1998. (punchng.com)
  • This virus was first identified in Malaysia and Singapore in 1998. (indiatimes.com)
  • Outbreak of Hendra-like virus-Malaysia and Singapore, 1998-1999. (cdc.gov)
  • Scientists have been playing catch-up since they detected the first Nipah virus outbreak in Malaysia in 1998. (flutrackers.com)
  • Since 1998 the Nipah virus has triggered disease outbreaks in Austral. (bio-medicine.org)
  • Since 1998, the Nipah virus has triggered disease outbreaks in Australia, Singapore, Malaysia and Bangladesh. (bio-medicine.org)
  • The first reported outbreak of Nipah virus in Malaysia occurred between 1998 and 1999, sickening 265 people and killing 105. (bio-medicine.org)
  • Experts reported that the Nipah virus epidemic which began in the Malaysian Peninsula in October 1998 was now over and risk of spread to other countries is very low. (pighealth.com)
  • Nipah/Bukit Pelanduk from 1998. (pighealth.com)
  • The infective virus was named after Nipah, a Malaysian village after the virus was first identified in the year 1998. (yashodahospitals.com)
  • The first case of Nipah virus was reported in 1998 in Malaysia. (avivaindia.com)
  • NiV is a zoonotic virus whose natural host is the fruit bat (Pteropus bat species) and its outbreak was first reported in 1998-99 when virus moved to pig farmers from pigs in Malaysia and Singapore, infecting 276 and resulting in 106 deaths. (alliedacademies.org)
  • The first case of Nipah virus (NiV) infection was initially reported in late September 1998 near Ipoh, West Malaysia. (cureus.com)
  • The virus itself was isolated the following year in 1999. (wikipedia.org)
  • The virus was isolated and identified in 1999. (wikipedia.org)
  • Tests point to the Nipah virus, which debuted during a devastating outbreak in Malaysia in 1999. (sciencemag.org)
  • The virus was first identified in 1999 during an outbreak of illness affecting pig farmers and others in close contact with pigs in Malaysia and Singapore. (reuters.com)
  • Based on the experience gained during the outbreak of Nipah involving pig farms in 1999, routine and thorough cleaning and disinfection of pig farms with appropriate detergents may be effective in preventing infection. (outlookindia.com)
  • The Nipah virus was first identified in 1999, after farmers and others who had come in contact with infected pigs in Malaysia and Singapore developed severe respiratory problems and inflammation in the brain in 1999. (ndtv.com)
  • The rare, brain-damaging Nipah virus is a relatively new virus that was first discovered in 1999 during an outbreak in Malaysia. (ndtv.com)
  • Nipah Virus Infection in Dogs, Malaysia, 1999. (cambridge.org)
  • The virus was first isolated in March 1999 and based on its appearance, classified as a Paramyoviridae virus [4] . (cureus.com)
  • Her first frontline experience with infectious diseases were when the Nipah virus infected Singapore in 1999. (wikipedia.org)
  • Infective virus has also been isolated from environmental samples of bat urine and partially eaten fruit in Malaysia. (wikipedia.org)
  • The transmission of Nipah virus from flying foxes to pigs is thought to be due to an increasing overlap between bat habitats and piggeries in peninsular Malaysia. (wikipedia.org)
  • In this activity, students will play the role of epidemiologists, analyzing real data from an outbreak of Nipah virus in Malaysia, attempting to identify the reservoir of the virus and curtail the outbreak. (hhmi.org)
  • In Malaysia and Singapore, Nipah virus infected people with close contact to infected pigs. (wikipedia.org)
  • Nipah virus infection gets its name from the village in Malaysia where the person from whom the virus was first isolated succumbed to the disease. (indianexpress.com)
  • Nipah viruses from Malaysia and Bangladesh: two of a kind? (cambridge.org)
  • Nipah virus outbreak in Malaysia. (cambridge.org)
  • The virus was initially isolated from samples of bat urine and partially eaten fruits in Malaysia. (pediatriconcall.com)
  • There has been only sin-gle open la-bel trial ev-i-dence from Malaysia and it states that Ribavirin works against the virus. (pressreader.com)
  • It is enveloped negative-sense single-stranded RNA virus with a genome size of 18,252 (Bangladesh) and 18,246 (Malaysia) nucleotides. (alliedacademies.org)
  • Nipah is the name of the first village the virus struck near Kuala Lumpur in Malaysia. (drugster.info)
  • Nipah virus electron micrograph Image courtesy of C.S. Goldsmith and P.E. Rollin (CDC), and K.B. Chua (Malaysia). (drugster.info)
  • Nipah virus is also known to cause illness in pigs and people. (cdc.gov)
  • The CSIRO Dangerous Pathogens Team and colleauges at AAHL Geelong have undertaken transmission experiments with pigs to determine how the virus is shed from infected animals. (www.csiro.au)
  • In Geelong, AAHL scientists undertook transmission experiments with pigs to determine how they pass the virus to other pigs and to people. (www.csiro.au)
  • Doctors do not completely understand the contagious period for infection, but it likely begins during the incubation period (proven in pigs) and continues until the patient stops shedding virus. (medicinenet.com)
  • 2000 ).] On a previously infected farm, 95% of the pigs had Nipah virus antibodies. (cabi.org)
  • In contrast, the virus was responsible for a highly infectious respiratory disease with low mortality in pigs. (pnas.org)
  • The virus was first discovered in domestic pigs. (financialexpress.com)
  • While in the past, pigs have been a host of this virus, it can be transmitted from human to human contact as well. (organicfacts.net)
  • Because pigs are particularly susceptible to Nipah infection, public health officials could use these drugs to protect the animals, pig farmers and first-line responders, like paramedics, from a Nipah virus outbreak. (bio-medicine.org)
  • Farm workers became infected by pigs that developed severe respiratory disease and spread the virus by coughing. (ecohealthalliance.org)
  • One million pigs were slaughtered to control the virus. (pighealth.com)
  • The abattoir had imported pigs from a Malaysian farm infected with Nipah virus. (pighealth.com)
  • Other animals such as pigs and domestic animals such as dogs and cats can be intermediate hosts for the virus as well. (pediatriconcall.com)
  • Nipah and Hendra can infect and cause serious and often highly fatal disease in people and also in pigs, horses, cats, dogs, and several other animal species. (hjf.org)
  • Recombinant Nipah Virus Vaccines Protect Pigs against Challenge" by Hana M. Weingartl, Yohannes Berhane et al. (iastate.edu)
  • Canarypox virus-based vaccine vectors carrying the gene for NiV glycoprotein (ALVAC-G) or the fusion protein (ALVAC-F) were used to intramuscularly immunize four pigs per group, either with 10 8 PFU each or in combination. (iastate.edu)
  • Virus was not isolated from the tissues of any of the vaccinated pigs postchallenge, and a real-time reverse transcription (RT)-PCR assay detected only small amounts of viral RNA in several samples. (iastate.edu)
  • In challenge control pigs, virus was isolated from a number of tissues (10 4.4 PFU/g) or detected by real-time RT-PCR. (iastate.edu)
  • No virus shedding was detected in vaccinated animals, in contrast to challenge control pigs, from which virus was isolated from the throat and nose (10 2.9 PFU/ml). (iastate.edu)
  • The virus spreads when pigs or other animals consume the half-eaten fruits left by the fruit bat. (avivaindia.com)
  • Amino acid multiple alignment of the attachment glycoprotein (G) of three Nipah virus (NiV) isolates used in the study. (cdc.gov)
  • The research group developed a vaccine based on a Hendra virus surface protein, the G glycoprotein, a known target for triggering a protective host immune response. (medindia.net)
  • They found that immunizing African green monkeys with a vaccine based on the Hendra virus attachment G glycoprotein completely protected them against Nipah virus infection. (drugs.com)
  • Passive immunisation using a human monoclonal antibody that targets the Nipah G glycoprotein has been evaluated in the ferret model as post-exposure prophylaxis. (rediff.com)
  • Soluble glycoprotein vaccines and virus vector platforms are protective in experimental animals. (pearltrees.com)
  • Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein. (nih.gov)
  • We have previously shown that peptides corresponding to the C-terminal heptad repeat (HR-2) of the fusion envelope glycoprotein of Hendra virus and Nipah virus were potent inhibitors of both Hendra virus and Nipah virus-mediated membrane fusion using recombinant expression systems. (nih.gov)
  • Research scientists at the Uniformed Services University of the Health Sciences (USU), along with collaborators from other institutions, have developed the first treatment for and the first vaccine against the deadly Hendra and Nipah viruses (respectively, a human monoclonal antibody and a recombinant soluble Hendra virus G glycoprotein [sG] vaccine). (federallabs.org)
  • The vaccine component is just a single protein from the virus known as the G glycoprotein which is produced in a soluble form (sG) in cell culture by genetic means and purified to exceedingly high levels. (globenewswire.com)
  • No virus or any infectious agent is involved in the production of the sG glycoprotein vaccine. (globenewswire.com)
  • Affinity selection on Nipah Virus-neutralizing monoclonal antibodies using random sequence peptide libraries on MS2 VLPs selected peptides with sequence similarity to peptide sequences found within the envelope glycoprotein of Nipah itself, thus identifying the epitopes the antibodies recognize. (osti.gov)
  • The selected peptide sequences themselves are not necessarily identical in all respects to a sequence within Nipah Virus glycoprotein, and therefore may be referred to as epitope mimics VLPs displaying these epitope mimics can serve as vaccine. (osti.gov)
  • The Nipah and Hendra virus use the G glycoprotein to attach to and infect cells. (hjf.org)
  • Here we took advantage of the natural tropism of Nipah virus (NiV), whose attachment envelope glycoprotein has picomolar affinity for ephrinB2, a molecule proposed as a molecular marker of 'stemness' (present on embryonic, hematopoietic, and neural stem cells) as well as being implicated in tumorigenesis of specific cancers. (ca.gov)
  • Primary Antibodies-Rabbit anti-Nipah virus (anti-NiV) Glycoprotein antiserum-Alpha Diagnostic International Inc. (4adi.com)
  • Nipah virus has been isolated from Lyle's flying fox (Pteropus lylei) in Cambodia and viral RNA found in urine and saliva from P. lylei and Horsfield's roundleaf bat (Hipposideros larvatus) in Thailand. (wikipedia.org)
  • Other regions may be at risk for infection, as evidence of the virus has been found in the known natural reservoir (Pteropus bat species) and several other bat species in a number of countries, including Cambodia, Ghana, Indonesia, Madagascar, the Philippines, and Thailand. (outlookindia.com)
  • Upon transmission of Nipah virus from its natural reservoir, Pteropus spp. (sciencemag.org)
  • Host del virus murciélagos frugívoros de la familia Pteropodidae, que pertenece al género Pteropus. (gentaur.com)
  • Imphal, May 29: No case of Nipah virus has been detected in the northeast, an official said on Tuesday, denying misleading social media reports about its presence in the region. (sentinelassam.com)
  • There has been no new case of Nipah virus reported from anywhere in the country. (aninews.in)
  • A Nipah virus infection is a viral infection caused by the Nipah virus. (wikipedia.org)
  • Dr. Schnell, together with the first author and graduate student Rohan Keshwara, took advantage of a modified rabies virus vector, and incorporated a gene from Nipah virus - creating a viral particle that displays components of both viruses on its surface. (eurekalert.org)
  • Because the immune system interacts with both viral components, it develops a reaction that is specific and can defend against both viruses. (eurekalert.org)
  • Nipah is a potentially fatal viral disease. (internationalsos.com)
  • THIRUVANANTHAPURAM: A letter written by a Keralite nurse minutes before she died of the 'Nipah' virus has gone viral in the social media, leaving people teary-eyed. (indiatimes.com)
  • Vaccines work by exposing a person to a small amount of modified virus or viral proteins, which rallies the body's natural defense. (eurekalert.org)
  • Chicken pox is an acute and highly contagious viral infection caused by the varicella zoster virus. (medindia.net)
  • To infect a cell viruses must bind to a viral-specific receptor on th. (bio-medicine.org)
  • To infect a cell, viruses must bind to a viral-specific receptor on the cell's surface in order to penetrate it. (bio-medicine.org)
  • Barnett left to attend graduate school at Harvard University and Bruhn and colleagues continued working on the project, focusing on the P protein, a key component of the viral replication complex, which is essential for the virus to replicate its RNA. (healthcanal.com)
  • Even though Ebola and the Nipah virus are from different viral families, this drug has shown promise fighting against both diseases. (passporthealthusa.com)
  • Being aware and prepared for the Nipah viral epidemic can help in controlling the situation. (yashodahospitals.com)
  • Nipah virus is one of the deadliest among viral-borne diseases. (avivaindia.com)
  • Fusion of enveloped viruses with the host cell is a key step in viral infectivity. (prolekare.cz)
  • and HJF, USU, and Profectus will collaborate on the development of a clinical assay for the evaluation of the anti-Nipah virus vaccine response. (globenewswire.com)
  • Anti Nipah Virus cat. (gentaur.com)
  • Twenty eight-year-old Lini working in the Perambra Taluk Hospital in Kozhikode got exposed to the 'deadly' virus while treating affected patients. (indiatimes.com)
  • The deadly Nipah virus and others like it assemble themselves in a much more haphazard manner than previously thought, new UBC research has found. (eurekalert.org)
  • For some of these deadly viruses, the replication process is actually not as complicated as some thought. (eurekalert.org)
  • The deadly Nipah virus has returned to Bangladesh, killing at least eight people since the latest outbreak was confirmed, officials said Sunday. (medindia.net)
  • WEDNESDAY, Aug. 8 -- A new vaccine developed by a team of researchers may protect people and livestock from the deadly Nipah virus. (drugs.com)
  • UCLA scientists have discovered how the deadly Nipah virus infiltrates. (bio-medicine.org)
  • This is part of a larger program to illuminate how these deadly viruses replicate. (healthcanal.com)
  • The team is continuing to work on understanding the virus and why it is so deadly. (healthcanal.com)
  • A possible outbreak of the deadly Nipah virus outbreak, for the second straight year, has been thwarted as there has been no report of suspected cases from anywhere in the state for over a week now. (indiatimes.com)
  • Nipah virus (NiV) is a deadly virus with a high mortality rate that has affected many developing countries in the past. (cureus.com)
  • The aim of this review is to provide an epidemiological background as well as to understand the transmission routes, presentation, and the diagnosis and prevention of this deadly virus. (cureus.com)
  • The results of blood samples of the student, which were tested at the National Institute of Virology in Pune, have confirmed Nipah, state Health minister K K Shailaja said here. (sify.com)
  • National Institute of Virology has confirmed from the studies on blood samples that three out of the four deaths attributed to fever was caused by the virus. (financialexpress.com)
  • The researchers, led by Dr. Heinz Feldmann, chief of the Rocky Mountain Laboratories' Laboratory of Virology, conducted their research on live Nipah virus in a high-security facility in Hamilton, Mont. (drugs.com)
  • As per the National Institute of Virology, Pune, Nipah Virus is the sole cause of these three deaths. (indiatimes.com)
  • Nipah virus (NiV) is a zoonotic virus, meaning that it can spread between animals and people. (cdc.gov)
  • Background Nipah virus (NiV) is a significant emerging zoonotic pathogen given its wide geographic distribution, and the severe morbidity and high mortality that accompanies infection. (pearltrees.com)
  • Hendra and Nipah viruses are two highly pathogenic zoonotic members of the genus Henipavirus , family Paramyxoviridae, requiring work under biosafety level 4 conditions due to a lack of effective therapy and human vaccines. (dovepress.com)
  • All suspected cases of Nipah virus infection should be isolated. (wikipedia.org)
  • All suspected cases of Nipah virus infection should be isolated and given intensive supportive care. (rediff.com)
  • Students explore cases of Nipah virus infection, analyze evidence, and make calculations and predictions based on data. (biointeractive.org)
  • The only way to treat this virus is through intensive supportive care. (rediff.com)
  • With no treatment outside of supportive care, Nipah virus is one of the diseases shortlisted by the World Health Organization as a priority for research and study. (ecohealthalliance.org)
  • Early supportive care and treatment of symptoms improves survival, but there is currently no licensed treatment for Nipah. (who.int)
  • Nipah virus infection is primarily treated with intensive supportive care. (yashodahospitals.com)
  • As there is no particular vaccine for the treatment of Nipah virus, intensive supportive care is the only way to treat the infection. (avivaindia.com)
  • There have been several outbreaks of Nipah virus in Bangladesh since 2001. (www.csiro.au)
  • In Bangladesh, death rates of repeated outbreaks of Nipah virus in the past four years have risen to 70 percent, suggesting that the virus is growing more lethal. (bio-medicine.org)
  • As of 2020[update] there is no specific treatment for Nipah virus infection. (wikipedia.org)
  • There is no specific treatment for Nipah Virus. (indianexpress.com)
  • There is no effective treatment for Nipah virus infection until now. (wikipedia.org)
  • There is no known treatment for Nipah virus and its symptoms move quickly from headache and drowsiness to coma in a matter of days. (ecohealthalliance.org)
  • A therapeutic treatment for Nipah virus disease is urgently needed. (sciencemag.org)
  • In contrast to control animals, which all succumbed to the infection, all remsdesivir-treated animals survived the lethal challenge, indicating that remdesivir represents a promising antiviral treatment for Nipah virus infection. (sciencemag.org)
  • Bangladesh has borne the brunt of the disease in recent years, with more than 100 people dying of Nipah since a first outbreak was reported in 2001. (punchng.com)
  • The Nipah virus has been classified by the Centers for Disease Control and Prevention as a Category C agent. (wikipedia.org)
  • Adapted from Nipah virus distribution map, Centers for Disease Control and Prevention ( www.cdc.gov/vhf/nipah/outbreaks/distribution-map.html ). (asm.org)
  • The U.S. National Institutes of Health and U.S. Centers for Disease Control and Prevention both classify the Nipah virus and the Hendra virus as biothreat agents. (drugs.com)
  • Since the virus is a biosafety level 4 pathogen, TSRI researchers can only look at parts of it but not the entire virus, so the scientists are collaborating with the Centers for Disease Control and Prevention to look at the role of this structure in infection. (healthcanal.com)
  • Gilead Sciences, Inc., is developing remdesivir and, in collaboration with scientists from the Centers for Disease Control and Prevention (CDC), performed initial laboratory studies evaluating the drug against Nipah virus. (medicalxpress.com)
  • 2019 Jun 01;27(2):117-127 Authors: Ochani RK, Batra S, Shaikh A, Asad A Abstract The Nipah virus was discovered twenty years ago, and there is considerable information available regarding the specificities surrounding this virus such as transmission, pathogenesis and genome. (medworm.com)
  • Exposure to viruses can occur through breathing in respiratory droplets from infected people, certain insect bites, and direct skin contact. (medicinenet.com)
  • Nipah patients who have breathing difficulty are more likely than those without respiratory illness to transmit the virus, as are those who are more than 45 years of age. (wikipedia.org)
  • The virus can cause symptoms like respiratory illness during the early part of the infection and may even lead to coma within 24-48 hours. (financialexpress.com)
  • The Nipah and Hendra viruses are members of the genus Henipavirus, a new class of virus in the Paramyxoviridae family, which includes the measles and the human parainfluenza virus (HPIV) that causes pediatric respiratory disease. (medindia.net)
  • The study showed in particular that adult cases with respiratory symptoms transmitted the virus to more individuals than other cases, and might therefore be targeted for interventions when the isolation of all suspected Nipah cases is not possible. (eurekalert.org)
  • Moreover, contacts exposed to body fluids, including respiratory secretions, were more likely to get infected than others- consistent with an important role of respiratory secretions in person-to-person transmission of Nipah virus. (eurekalert.org)
  • The incubation period of the virus is 3 to 14 days and affected patients may have high grade fever, headache and cough which may rapidly progress to breathing difficulty, respiratory failure, seizures, delirium and coma. (biospectrumasia.com)
  • The major biotech company ModernaTX, Inc. has been one of the forerunners in the race to develop an effective and safe vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the coronavirus disease (COVID-19). (news-medical.net)
  • The company wants to explore potential combination vaccines against flu, SARS-CoV-2, the respiratory syncytial virus (RSV), and the human metapneumovirus (hMPV). (news-medical.net)
  • Animals spread the virus to people, where it causes life-threatening respiratory and neurological diseases that kill up to 70 percent of patients ?a danger level equivalent to the Ebola virus. (bio-medicine.org)
  • All the control animals developed severe respiratory complications from the virus. (passporthealthusa.com)
  • it will also provide biologically relevant models for other respiratory viruses. (eur.nl)
  • Many patients also show pulmonary, neurological and respiratory signs after getting infected by the virus. (avivaindia.com)
  • The main tests used are IgM and IgG detection by enzyme-linked immunosorbent assay (ELISA), real-time polymerase chain reaction (RT-PCR) from bodily fluids like respiratory secretion, urine, CSF etc., and virus isolation using Vero cells. (alliedacademies.org)
  • Oxidant tone regulates RANTES gene expression in airway epithelial cells infected with respiratory syncytial virus. (microbiologyresearch.org)
  • Antioxidant treatment ameliorates respiratory syncytial virus-induced disease and lung inflammation. (microbiologyresearch.org)
  • Both Nipah and Hendra can cause severe respiratory illness and brain inflammation. (miragenews.com)
  • Nipah virus and Hendra virus are RNA viruses in the family of paramyxoviruses, making them distant cousins of human pathogens such as measles, mumps, respiratory syncytial, and Newcastle viruses. (miragenews.com)
  • She has led the country through Middle East respiratory syndrome (MERS), Influenza A virus subtype H7N9 (bird flu) and Dengue fever outbreaks. (wikipedia.org)
  • Outlook Web Bureau 2019-06-04T12:30:41+05:30 What Is Nipah Virus? (outlookindia.com)
  • Nipah virus is a paramyxovirus and is very closely related to Hendra virus. (www.csiro.au)
  • Nipah virus is a new member of the paramyxovirus family and is closely related to the Hendra virus. (www.csiro.au)
  • Nipah virus, a bat-borne paramyxovirus found throughout South and South East Asia, has been identified by WHO as an emerging infectious disease that may cause severe epidemics in the near future. (eurekalert.org)
  • Nipah virus is a bat-borne paramyxovirus found throughout South and South East Asia. (eurekalert.org)
  • Nipah virus is a paramyxovirus, an RNA virus belonging to the genus Henipavirus which also includes Hendra virus (measles is a distant cousin). (ecohealthalliance.org)
  • Nipah virus (NiV) is a member of the family Paramyxoviridae , genus Henipavirus and is related to Hendra virus that infects horses. (medicinenet.com)
  • Nipah virus belongs to the genus Henipavirus along with the Hendra virus, which has also caused disease outbreaks. (wikipedia.org)
  • The Nipah virus (NiV) is a type of RNA virus in the genus Henipavirus. (wikipedia.org)
  • Henipavirus, including Hendra virus (HeV) and Nipah virus (NiV), is a newly discovered human pathogen genus. (nih.gov)
  • The 2 viruses were combined into the genus Henipavirus , in the family Paramyxoviridae . (cdc.gov)
  • Both are classified as members of the Henipavirus genus of the virus family Paramyxoviridae of the Order Mononegavirales. (pighealth.com)
  • Serological surveys indicate that a fruit-eating bat of the Pteropid genus is probably a reservoir of the virus (which can also infect dogs, cats, rats and horses). (pighealth.com)
  • Nipah virus (NiV) is a highly lethal member of the family Paramyxoviridae , genus Henipavirus . (asm.org)
  • Nipah virus and Hendra virus is another virus that belongs to Hepina virus genus. (yashodahospitals.com)
  • The organism that causes Nipah virus is an RNA virus (virus that has ribonucleic acid as genetic material) of the family Paramyxoviridae, genus Henipavirus. (avivaindia.com)
  • NiV is a RNA virus that belongs to genus Henipavirus of Paramyxoviridae family. (alliedacademies.org)
  • Nipah virus is one of several viruses identified by WHO as a likely cause of a future epidemic in a new plan developed after the Ebola epidemic for urgent research and development before and during an epidemic toward new diagnostic tests, vaccines and medicines. (wikipedia.org)
  • We also used the same vaccine platform to develop vaccines against several other emerging viruses, including a vaccine against Ebola virus, which is close to entering into its first clinical trial. (eurekalert.org)
  • The discovery could allow scientists to develop more effective vaccines and rule out many approaches to fighting these viruses. (eurekalert.org)
  • There is currently no treatment or preventative vaccine to treat the virus but the World Health Organization has listed Nipah as a 'Blueprint priority disease' for urgent research in February, due to its "potential to cause a public health emergency and the absence of efficacious drugs and/or vaccines" 5 . (internationalsos.com)
  • There are currently no approved vaccines for prevention of infection and disease caused by Nipah and Hendra for use by people or livestock," corresponding author Christopher Broder, a professor of microbiology at the Uniformed Services University in Bethesda, Md., said in a university news release. (drugs.com)
  • With a case fatality of >70% and no available treatment or vaccines, Nipah virus was identified by the World Health Organization as an emerging infectious disease that may cause major epidemics if the pathogen evolves to become more transmissible, leading the organization to prioritize it for research to prevent future health emergencies. (eurekalert.org)
  • In the absence of efficient treatments or vaccines, the only way to control Nipah virus outbreaks are through targeted interventions that limit opportunities of spread. (eurekalert.org)
  • Vaccine Volume 34, Issue 26, 3 June 2016, Status of vaccine research and development of vaccines for Nipah virus. (pearltrees.com)
  • Now, the firm has announced that it is brewing new mRNA-based vaccines against other viruses, including the influenza virus, human immunodeficiency virus (HIV), and the Nipah virus. (news-medical.net)
  • One of the promising new vaccines used as a messenger ribonucleic acid (mRNA) vaccine, which differs from traditional vaccines that use live-attenuated or weakened viruses. (news-medical.net)
  • Specifically, mRNA vaccines against SARS-CoV-2 provide instructions for the cells to produce a harmless piece of the Spike protein (S protein), which is found on the surface of the virus itself and is the mechanism by which the virus latches onto and infiltrates host cells. (news-medical.net)
  • Apart from these vaccines, Moderna has also developed mRNA-based vaccines against the Zika virus, and pandemic influenza or H7N9 vaccine. (news-medical.net)
  • Also, the company is developing vaccines against other infections, such as the cytomegalus virus (CMV), Epstein-Barr virus (EBV), human metapneumovirus (hMPV), and the parainfluenza type 3 (PIV3) vaccine (mRNA-1653), to name a few. (news-medical.net)
  • Now that we understand how the virus operates, we can develop vaccines and drugs to block Nipah from entering the cells. (bio-medicine.org)
  • Despite causing regular outbreaks with high case fatality rates, there are currently no licensed vaccines or therapeutics for Nipah virus (NiV) infection. (pnas.org)
  • The geographical locations of the up to date HeV and NiV outbreaks correspond to the geographical distribution of the natural reservoir species in Australia (Hendra) and Southeast Asia (Nipah), respectively ( Figure 1 ). (dovepress.com)
  • The existence of a natural reservoir of virus (usually rodents and birds), virus transmitters (mosquitoes and ticks), and associated natural focality and seasonality are characteristic of most primary encephalitides. (thefreedictionary.com)
  • Adapted from WHO data ( http://www.searo.who.int/entity/emerging_diseases/links/nipah_virus_outbreaks_sear/en/ ). (asm.org)
  • Organisations need to be prepared to respond to an increasing number of outbreaks - many will already have plans for pandemic flu, which can be adapted to new diseases such as Nipah. (internationalsos.com)
  • When people first get Nipah virus infection, it looks like some other diseases. (wikipedia.org)
  • The WHO has named Nipah as one of the eight priority diseases that could cause a global epidemic, alongside the likes of Ebola and Zika. (punchng.com)
  • The Nipah virus , alongside Ebola and Zika, is listed as one of eight diseases that could cause a global epidemic by the World Health Organization. (passporthealthusa.com)
  • any one of a group of inflammatory diseases of the human and animal brains caused mainly by viruses, bacteria, protozoans, and other pathogenic microorganisms. (thefreedictionary.com)
  • Other causes include enterovirus infections or mosquito-borne viruses. (medicinenet.com)
  • To examine the role played by the different virus proteins in the pathology of NiV infections, it is necessary to be able to manipulate the virus genes within the complete virus genome. (pnas.org)
  • Infections by these viruses target the lungs and brain, and disease outbreaks have occurred regularly in the past decade. (medindia.net)
  • The researchers said they hope that these types of laboratory discoveries will pave the way toward preventing Nipah virus and Hendra virus infections or provide a solution for post-exposure therapy. (miragenews.com)
  • Nipah virus is an RNA virus belonging to Paramyxoviridae family and Henipavirus group. (pediatriconcall.com)
  • Nipah virus is an emerging pathogen in the Paramyxoviridae family. (sciencemag.org)
  • Dr White worked with the Veterinary Research Institute in Ipoh to develop a test to show if animals had antibodies to the virus, indicating previous exposure. (www.csiro.au)
  • Dr. Schnell and colleagues demonstrated that one dose of vaccine elicited a strong antibodies response against Nipah virus and rabies virus. (eurekalert.org)
  • Those antibodies also react to a virus from the same family as Nipah, the Hendra virus, which causes similar symptoms. (eurekalert.org)
  • After this antigen triggers an immune response, the body produces neutralizing antibodies , which become primed and ready to fight off the real virus if it ever enters the body. (news-medical.net)
  • Blood analysis during acute and chronic stage of the disease will show antibodies (IgM and IgG) against the virus and this helps in confirming the diagnosis. (pediatriconcall.com)
  • Intended Use qualitative detection of IgG antibodies to Nipah Virus in in human serum and plasma. (gentaur.com)
  • Other researchers have discovered antibodies that block attachment of Nipah and Hendra viruses to host cells. (miragenews.com)
  • Nipah virus - the rising epidemic: a review. (medworm.com)
  • Epidemic preparedness and the ability to stop transmission efficiently during an outbreak can only be achieved through a detailed understanding of the drivers of Nipah transmission. (eurekalert.org)
  • The license, supported by the Coalition for Epidemic Preparedness Innovations (CEPI), has been awarded to Profectus BioSciences, Inc. and Emergent BioSolutions Inc. (NYSE: EBS) who will collaborate to develop the human vaccine for Nipah and Hendra viruses. (globenewswire.com)
  • Choubey, while interacting with media, said the virus is not epidemic and people should not be scared of it. (aninews.in)
  • Nipah is not epidemic and there is nothing to be scared of," Choubey said. (aninews.in)
  • Nipah is an example of an "enveloped" virus, which gets its outer wrapping from the infected host cell, much like the viruses that cause influenza, rabies, measles and AIDS. (eurekalert.org)
  • This observation has implications for vaccination, not just against Nipah but potentially against influenza, HIV and other enveloped viruses. (eurekalert.org)
  • Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals. (microbiologyresearch.org)
  • The rescued NiV (rNiV), by using the newly developed reverse genetics system, showed properties in vitro that were similar to the parent virus and retained the severe pathogenicity in a previously established animal model by experimental infection. (pnas.org)
  • Recently, reports of a male student been affected by Nipah virus in Kerala's Ernakulam district have caused severe panic in the state. (outlookindia.com)
  • Nipah Virus is usually associated with inflammation of the brain due to which severe days of fever can often lead to a state of confusion, disorientation and even persistent drowsiness. (indiatimes.com)
  • FMD is the most worrying disease because of the severe impact of new strains of the virus on cattle and pig production. (pighealth.com)
  • Remdesivir is the second experimental treatment, after monoclonal antibody m102.4, shown to prevent severe Nipah virus disease in a monkey model when administered after the animals are infected. (medicalxpress.com)
  • Nipah is on the WHO's research and development "priority pathogen" list alongside Ebola, Zika, MERS, Lassa and Crimean-Congo haemorrhagic fever. (reuters.com)
  • Fears of a pandemic have been raised in recent times following serious outbreaks of both the Zika and Ebola viruses on different continents. (rt.com)
  • Earlier this month, the WHO warned that the recent Ebola outbreak in the Democratic Republic of Congo is on an "epidemiological knife's edge" amid concerns that the virus could spread to urban areas. (rt.com)
  • Nipah's human-to-human transmission has been documented, and an initially small outbreak could take the same course as the recent Ebola virus outbreak witnessed in West Africa. (globenewswire.com)
  • While helping in the ongoing Ebola outbreak, this vaccine could also be a needed breakthrough for Nipah. (passporthealthusa.com)
  • Did you know the Ebola and Nipah viruses were so closely related? (passporthealthusa.com)
  • tested the nucleotide prodrug remdesivir (GS-5734), which has shown activity against other pathogens such as Ebola virus, in a nonhuman primate model. (sciencemag.org)
  • this virus was related to, but distinct from, the Hendra virus discovered in Australia in 1994. (cabi.org)
  • The Nipah virus is similar to Hendra virus that was discovered in Australia in 1994. (drugster.info)
  • All nine vaccinated animals survived a lethal Nipah virus challenge given 42 days after the initial vaccination. (medindia.net)
  • A potential new treatment for the Nipah and Hendra viruses, two lethal and emerging viruses for which there is currently no treatment or vaccine available has been identified by scientists. (medindia.net)
  • Both of these symptoms can be lethal and currently Nipah virus has no known vaccine. (passporthealthusa.com)
  • The monkeys were infected with a lethal dose of the virus and then given their first dose of remdesivir 24 hours later. (passporthealthusa.com)
  • The experimental antiviral drug remdesivir completely protected four African green monkeys from a lethal dose of Nipah virus, according to a new study in Science Translational Medicine from National Institutes of Health scientists and colleagues. (medicalxpress.com)
  • Animals infected with a lethal dose of Nipah virus received a first dose of intravenous remdesivir 24 hours after infection and then a daily intravenous dose for a total of 12 consecutive days. (medicalxpress.com)
  • Four untreated animals also received a lethal dose of Nipah virus. (medicalxpress.com)
  • Animals were administered a lethal dose of Nipah virus, and half were treated daily with remdesivir starting 24 hours later. (sciencemag.org)
  • Animals were inoculated with a lethal dose of Nipah virus, and a once-daily intravenous remdesivir treatment was initiated 24 hours later and continued for 12 days. (sciencemag.org)
  • The WHO claims the virus to be highly lethal with an average fatality rate of 75 percent. (avivaindia.com)
  • The in vivo efficacy of cholesterol-tagged peptides, and in particular their ability to penetrate the CNS, suggests that they are promising candidates for the prevention or therapy of infection by Nipah and other lethal paramyxoviruses. (prolekare.cz)
  • The first people infected with Nipah virus are believed to have been pig farm workers living near Ipoh, Malaysia's third biggest city, in January 1997. (www.csiro.au)
  • The spread of the Nipah virus illustrates a problem due to trends in livestock production -- large-scale production and international commerce. (drugster.info)
  • Some infectious agents such as the Nipah virus are associated with intensity of production and concentration of animals in limited spaces. (drugster.info)
  • International commerce in meat and poultry now increases the chance of the worldwide dissemination of exotic infectious agents like the Nipah virus. (drugster.info)
  • The World Health Organization (WHO) therefore lists Nipah virus as a priority pathogen needing urgent action. (eurekalert.org)
  • Mapping the risk of Nipah virus spillover into human populations in South and Southeast Asia. (pearltrees.com)
  • The samples tested positive for Nipah virus. (who.int)
  • B) CD31 positive endothelium of pulmonary vasculature is positive for Nipah virus antigen (40× magnification). (nih.gov)
  • Currently, there is no approved vaccine against Nipah virus available on the market. (eurekalert.org)
  • A vaccine against Nipah virus has been successfully tested in monkeys by scientists. (medindia.net)
  • This work now provides key evidence that a simple and safe recombinant vaccine against Nipah virus is possible," study co-author Thomas Geisbert, professor in the department of microbiology and immunology at the University of Texas Medical Branch and the Galveston National Laboratory, said in the news release. (drugs.com)
  • The monoclonal antibody has been successfully administered (through a compassionate use exception) to three individuals in Australia who had significant exposure to Hendra virus from contact with infected horses. (federallabs.org)
  • In this latest study, scientists isolated from mice, and then humanized, a potent monoclonal antibody that neutralizes both Nipah and Hendra viruses. (miragenews.com)
  • For example, various media outlets stated that the virus is spread by fruit which ultimately led to a massive shut down of fruit shops locally and fruit bans in surrounding countries like the UAE 4 . (internationalsos.com)
  • In particular, the high mortality and person to person transmission associated with the most recent Nipah virus outbreaks, as well as the very recent re-emergence of Hendra virus, has confirmed the importance of developing effective therapeutic interventions. (nih.gov)
  • Approximately one-half of recognized Nipah case patients in Bangladesh developed their disease following person-to-person transmission of the virus. (nih.gov)
  • Furthermore, transmission between farms may be due to fomites - or carrying the virus on clothing, equipment, boots, vehicles. (indianexpress.com)
  • Experts are of the opinion that Nipah Virus is an airborne transmission infection and can affect those who come in direct contact with contaminated bodies. (rediff.com)
  • With no available treatment or vaccine, the control of Nipah virus outbreaks must rely on a detailed understanding of factors that may facilitate inter-human transmission. (eurekalert.org)
  • Further insights on mechanisms of person-to-person transmission of Nipah virus are therefore urgently needed. (eurekalert.org)
  • To unravel the drivers of person-to-person transmission of Nipah virus, researchers from the Institut Pasteur, CNRS, icddr,b, IEDCR, US CDC and Johns Hopkins Bloomberg School of Public Health studied the characteristics of all Nipah cases and over 2000 of their contacts identified during the last 14 years of outbreak investigations in Bangladesh, the country that has reported the largest number of cases. (eurekalert.org)
  • The risk of transmission of Nipah virus depends on the characteristics of the case, like the age or the type of symptoms. (eurekalert.org)
  • Person-to-Person Transmission of Nipah Virus in a Bangladeshi Community. (cambridge.org)
  • Hendra virus ecology and transmission. (pearltrees.com)
  • Nipah Virus is not an airborne transmission infection, and only affects those who come in direct contact with the infected body. (avivaindia.com)
  • ABC 03/06/16 Black and spectacled flying foxes are main Hendra virus carriers, research shows. (pearltrees.com)
  • As explained by Birgit Nikolay, first author of the study, « the results of this study help identify patients that should be targeted for interventions such as isolation measures if resources are insufficient to cover all suspected Nipah cases. (eurekalert.org)
  • A statement from Kerala's Health Minister K K Shylaja said a task force has been constituted and a special intensive care unit and isolation ward have been arranged at Kozhikode medical college to address suspected Nipah cases. (indianexpress.com)
  • Numerous disease outbreaks caused by Nipah virus have occurred in South and Southeast Asia. (wikipedia.org)
  • In our empirical force field-based simulations, characteristic structures and helicities of α-MoREs reveal the co-existence of partially structured and disordered conformations, as in the case of the well characterized cognate measles virus (MeV) α-MoRE. (nih.gov)
  • It was surprising to us that this structure is so similar to those from measles and mumps viruses, even though they are only 5 to 26% identical in sequence," Bruhn said. (healthcanal.com)