A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
A calcium channel blocker that is a class IV anti-arrhythmia agent.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.
Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Excessive growth of the gingiva either by an increase in the size of the constituent cells (GINGIVAL HYPERTROPHY) or by an increase in their number (GINGIVAL HYPERPLASIA). (From Jablonski's Dictionary of Dentistry, 1992, p574)
A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.
Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete.
A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Administration of a soluble dosage form by placement under the tongue.
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
Drugs used to cause dilation of the blood vessels.
A neurotoxic peptide, which is a cleavage product (VIa) of the omega-Conotoxin precursor protein contained in venom from the marine snail, CONUS geographus. It is an antagonist of CALCIUM CHANNELS, N-TYPE.
A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
The nonstriated involuntary muscle tissue of blood vessels.
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
Any drug treatment modality designed to inhibit UTERINE CONTRACTION. It is used in pregnant women to arrest PREMATURE LABOR.
A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
Coronary vasodilator that is an analog of iproveratril (VERAPAMIL) with one more methoxy group on the benzene ring.
A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.
A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
The profession of writing. Also the identity of the writer as the creator of a literary production.
A publication issued at stated, more or less regular, intervals.
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.

Neural modulation of cephalexin intestinal absorption through the di- and tripeptide brush border transporter of rat jejunum in vivo. (1/2286)

Intestinal absorption of beta-lactamine antibiotics (e.g., cefixime and cephalexin) has been shown to proceed through the dipeptide carrier system. In a previous study, nifedipine (NFP), an L-type calcium channel blocker, enhanced the absorption of cefixime in vivo but not in vitro, and it was suggested that neural mechanisms might be involved in the effect of NFP. The aim of the present study was to assess the involvement of the nervous system on the intestinal absorption of cephalexin (CFX). To investigate this, we used a single-pass jejunal perfusion technique in rats. NFP and diltiazem enhanced approximately 2-fold the plasma levels of CFX in treated rats versus untreated controls. NFP also increased approximately 2-fold the CFX level in portal plasma and increased urinary excretion of CFX, thus indicating that CFX did effectively increase CFX intestinal absorption. Perfusing high concentrations of dipeptides in the jejunal lumen competitively reduced CFX absorption and inhibited the enhancement of CFX absorption produced by NFP. Hexamethonium and lidocaine inhibited the effect of NFP, whereas atropine, capsaicin, clonidine, and isoproterenol enhanced CFX absorption by the same order of magnitude as NFP. Thus, complex neural networks can modulate the function of the intestinal di- and tripeptide transporter. Sympathetic noradrenergic fibers, intestinal sensory neurons, and nicotinic synapses are involved in the increase of CFX absorption produced by NFP.  (+info)

Effects of Ca2+ concentration and Ca2+ channel blockers on noradrenaline release and purinergic neuroeffector transmission in rat tail artery. (2/2286)

1. The effects of Ca2+ concentration and Ca2+ channel blockers on noradrenaline (NA) and adenosine 5'-triphosphate (ATP) release from postganglionic sympathetic nerves have been investigated in rat tail arteries in vitro. Intracellularly recorded excitatory junction potentials (e.j.ps) were used as a measure of ATP release and continuous amperometry was used to measure NA release. 2. Varying the extracellular Ca2+ concentration similarly affected the amplitudes of e.j.ps and NA-induced oxidation currents evoked by trains of ten stimuli at 1 Hz. 3. The N-type Ca2+ blocker, omega-conotoxin GVIA (omega-CTX GVIA, 0.1 microM) reduced the amplitudes of both e.j.ps (evoked by trains of ten stimuli at 1 Hz) and NA-induced oxidation currents (evoked by trains of ten stimuli at 1 Hz and 50 stimuli at 10 Hz) by about 90%. 4. The omega-CTX GVIA resistant e.j.ps and NA-induced oxidation currents evoked by trains of 50 stimuli at 10 Hz were abolished by the non-selective Ca2+ channel blocker, Cd2+ (0.1 mM), and were reduced by omega-conotoxin MVIIC (0.5 microM) and omega-agatoxin IVA (40 nM). 5. Nifedipine (10 microm) had no inhibitory effect on omega-CTX GVIA resistant e.j.ps and NA-induced oxidation currents. 6. Thus both varying Ca2+ concentration and applying Ca2+ channel blockers results in similar effects on NA and ATP release from postganglionic sympathetic nerves. These findings are consistent with the hypothesis that NA and ATP are co-released together from the sympathetic nerve terminals.  (+info)

The Ca2+ channel blockade changes the behavioral and biochemical effects of immobilization stress. (3/2286)

We investigated how the effects of chronic immobilization stress in rats are modified by Ca2+ channel blockade preceding restraint sessions. The application of nifedipine (5 mg/kg) shortly before each of seven daily 2 h restraint sessions prevented the development of sensitized response to amphetamine as well as the stress-induced elevation of the densities of L-type Ca2+ channel in the hippocampus and significantly reduced the elevation of the densities of [3H]nitrendipine binding sites in the cortex and D1 dopamine receptors in the limbic forebrain. Neither stress, nor nifedipine affected the density of alpha 1-adrenoceptors and D1 receptors in the cerebral cortex nor D2 dopamine receptors in the striatum. A single restraint session caused an elevation of blood corticosterone level that remained unaffected by nifedipine pretreatment, but the reduction of this response during the eighth session was significantly less expressed in nifedipine-treated rats. We conclude that L-type calcium channel blockade prevents development of several stress-induced adaptive responses.  (+info)

Sympathetic neuroeffector transmission in the rat anococcygeus muscle. (4/2286)

1. When intracellular recordings were made from preparations of rat anococcygeus muscle, transmural nerve stimulation evoked noradrenergic excitatory junction potentials (EJPs) made up of two distinct components. Both components were abolished by either guanethidine or alpha-adrenoceptor antagonists, indicating that they resulted from the release of transmitter from sympathetic nerves and the subsequent activation of alpha-adrenoceptors. 2. The first component was associated with a transient increase in the intracellular concentration of calcium ions ([Ca2+]i) and a contraction. Although the second component was often associated with a long lasting increase in [Ca2+]i it was not associated with a contraction unless the second component initiated an action potential. 3. The increase in [Ca2+]i associated with the first component resulted from Ca2+ release from an intracellular store and from entry of Ca2+ through voltage-dependent Ca2+ channels. The increase in [Ca2+]i associated with the second component resulted only from the entry of Ca2+ through L-type Ca2+ channels (CaL channels). The depolarization associated with the initial increase in [Ca2+]i was abolished by reducing the external concentration of chloride ions ([Cl-]o), suggesting that it involved the activation of a Cl- conductance. 4. When the relationships between changes in [Ca2+]i, membrane depolarization and contraction produced by an increasing number of sympathetic nerve stimuli were determined in control, and caffeine- and nifedipine-containing solutions, it was found that an increase in [Ca2+]i recorded in nifedipine produced a larger contraction and larger membrane depolarization than did a similar increase in [Ca2+]i recorded in either control or caffeine-containing solutions. These observations indicate that Ca2+ released from stores more readily triggers contraction and membrane depolarization than does Ca2+ entry via CaL channels.  (+info)

Relationship between L-type Ca2+ current and unitary sarcoplasmic reticulum Ca2+ release events in rat ventricular myocytes. (5/2286)

1. The time courses of Ca2+ current and Ca2+ spark occurrence were determined in single rat ventricular myocytes voltage clamped with patch pipettes containing 0.1 microM fluo-3. Acquisition of line-scan images on a laser scanning confocal microscope was synchronized with measurement of Cd2+-sensitive Ca2+ currents. In most cells, individual Ca2+ sparks were observed by reducing Ca2+ current density with nifedipine (0.1-8 microM). 2. Ca2+ sparks elicited by depolarizing voltage-clamp pulses had a peak [Ca2+] amplitude of 289 +/- 3 nM with a decay half-time of 20.8 +/- 0.2 ms and a full width at half-maximum of 1.40 +/- 0.03 microm (mean +/- s. e.m., n = 345), independent of the membrane potential. 3. The time between the beginning of a depolarization and the initiation of each Ca2+ spark was calculated and data were pooled to construct waiting time histograms. Exponential functions were fitted to these histograms and to the decaying phase of the Ca2+ current. This analysis showed that the time constants describing Ca2+ current and Ca2+ spark occurrence at membrane potentials between -30 mV and +30 mV were not significantly different. At +50 mV, in the absence of nifedipine, the time constant describing Ca2+ spark occurrence was significantly larger than the time constant of the Ca2+ current. 4. A simple model is developed using Poisson statistics to relate macroscopic Ca2+ current to the opening of single L-type Ca2+ channels at the dyad junction and to the time course of Ca2+ spark occurrence. The model suggests that the time courses of macroscopic Ca2+ current and Ca2+ spark occurrence should be closely related when opening of a single L-type Ca2+ channel initiates a Ca2+ spark. By comparison with the data, the model suggests that Ca2+ sparks are initiated by the opening of a single L-type Ca2+ channel at all membrane potentials encountered during an action potential.  (+info)

Voltage-dependent entry and generation of slow Ca2+ oscillations in glucose-stimulated pancreatic beta-cells. (6/2286)

The role of voltage-dependent Ca2+ entry for glucose generation of slow oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i) was evaluated in individual mouse pancreatic beta-cells. Like depolarization with K+, a rise of the glucose concentration resulted in an enhanced influx of Mn2+, which was inhibited by nifedipine. This antagonist of L-type Ca2+ channels also blocked the slow oscillations of [Ca2+]i induced by glucose. The slow oscillations occurred in synchrony with variations in Mn2+ influx and bursts of action currents, with the elevation of [Ca2+]i being proportional to the frequency of the action currents. A similar relationship was obtained when Ca2+ was replaced with Sr2+. Occasionally, the slow [Ca2+]i oscillations were superimposed with pronounced spikes temporarily arresting the action currents. It is concluded that the glucose-induced slow oscillations of [Ca2+]i are caused by periodic depolarization with Ca2+ influx through L-type channels. Ca2+ spiking, due to intracellular mobilization, may be important for chopping the slow oscillations of [Ca2+]i into shorter ones characterizing beta-cells situated in pancreatic islets.  (+info)

Contribution of L-type Ca2+ current to electrical activity in sinoatrial nodal myocytes of rabbits. (7/2286)

The role of L-type calcium current (ICa,L) in impulse generation was studied in single sinoatrial nodal myocytes of the rabbit, with the use of the amphotericin-perforated patch-clamp technique. Nifedipine, at a concentration of 5 microM, was used to block ICa,L. At this concentration, nifedipine selectively blocked ICa,L for 81% without affecting the T-type calcium current (ICa,T), the fast sodium current, the delayed rectifier current (IK), and the hyperpolarization-activated inward current. Furthermore, we did not observe the sustained inward current. The selective action of nifedipine on ICa,L enabled us to determine the activation threshold of ICa,L, which was around -60 mV. As nifedipine (5 microM) abolished spontaneous activity, we used a combined voltage- and current-clamp protocol to study the effects of ICa,L blockade on repolarization and diastolic depolarization. This protocol mimics the action potential such that the repolarization and subsequent diastolic depolarization are studied in current-clamp conditions. Nifedipine significantly decreased action potential duration at 50% repolarization and reduced diastolic depolarization rate over the entire diastole. Evidence was found that recovery from inactivation of ICa,L occurs during repolarization, which makes ICa,L available already early in diastole. We conclude that ICa,L contributes significantly to the net inward current during diastole and can modulate the entire diastolic depolarization.  (+info)

Delayed rectifier potassium current in undiseased human ventricular myocytes. (8/2286)

OBJECTIVE: The purpose of the study was to investigate the properties of the delayed rectifier potassium current (IK) in myocytes isolated from undiseased human left ventricles. METHODS: The whole-cell configuration of the patch-clamp technique was applied in 28 left ventricular myocytes from 13 hearts at 35 degrees C. RESULTS: An E-4031 sensitive tail current identified the rapid component of IK (IKr) in the myocytes, but there was no evidence for an E-4031 insensitive slow component of IK (IKs). When nifedipine (5 microM) was used to block the inward calcium current (ICa), IKr activation was fast (tau = 31.0 +/- 7.4 ms, at +30 mV, n = 5) and deactivation kinetics were biexponential and relatively slow (tau 1 = 600.0 +/- 53.9 ms and tau 2 = 6792.2 +/- 875.7 ms, at -40 mV, n = 7). Application of CdCl2 (250 microM) to block ICa altered the voltage dependence of the IKr considerably, slowing its activation (tau = 657.1 +/- 109.1 ms, at +30 mV, n = 5) and accelerating its deactivation (tau = 104.0 +/- 18.5 ms, at -40 mV, n = 8). CONCLUSIONS: In undiseased human ventricle at 35 degrees C IKr exists having fast activation and slow deactivation kinetics; however, there was no evidence found for an expressed IKs. IKr probably plays an important role in the frequency dependent modulation of repolarization in undiseased human ventricle, and is a target for many Class III antiarrhythmic drugs.  (+info)

Oral Nifedipine and Atenolol Are Comparable Agents. Inpharma Wkly. 545, 11 (1986). https://doi.org/10.1007/BF03299482. Download ...
There are several concerns with this trial (25): 1) the mean (±SD) of diastolic blood pressure in the nifedipine group was 78 ± 11 mm Hg. In patients with chronic severe AR, this measure is very much lower, which suggests that most patients in the nifedipine group did not have severe AR. Moreover, the LV end-diastolic volume index was 94 ± 27 ml/m2, whereas in the Padua trial it was 126 ± 16 ml/m2 (26), which supports that many patients in the Barcelona trial did not have chronic severe AR; 2) there were 32 patients in the nifedipine arm, 7 (22%) dropped out at 2 ± 7 months, thus, only a small number of patients were randomized. In the Padua trial there were 69 patients in the nifedipine group and 4 were lost to follow-up; and 3) there was no change in blood pressure in the Barcelona trial in which nifedipine 20 mg twice a day was given. In the Padua trial, long-acting nifedipine 20 mg was given twice a day, and at the end of the trial there were significant reductions of LV volumes and ...
In a multicenter double-blind study, 227 patients with suspected acute myocardial infarction (AMI) were randomized within 12 hr from onset of symptoms to treatment with nifedipine (112 patients) or placebo (115 patients). AMI was confirmed in 74 patients on nifedipine and in 83 on placebo. Patients with AMI received nifedipine 5.5 +/- 2.9 hr (mean +/- SD) after onset of symptoms. Infarct size was assessed by the release of creatine kinase isoenzyme MB (CK-MB). Infarct size index (CK-MB geq/m2) was 25 +/- 16 (n = 71) in the nifedipine group and 23 +/- 13 (n = 77) in the placebo group (NS). After the first 10 mg of nifedipine systolic blood pressure fell from 147 +/- 30 to 135 +/- 28 mm Hg (p less than .01) and heart rate rose from 75 +/- 18 to 79 +/- 19 beats/min (p less than .01). No change was observed after the first placebo dose. The treatment was continued for 6 weeks. Over this period there were 10 deaths in each group. Early treatment with nifedipine in patients with AMI does not seem to ...
Dihydropyridines (DHP), which nifedipine is a member of, preferentially block Ca2+ channels of different cell types. Moreover, influx of Ca2+ through L-type Ca2+ channels (LTCCs) activates Ca2+ signaling pathways, which in turn contribute to numerous cellular processes. Although LTCCs are expressed in undifferentiated cells, very little is known about its contributions to the transcriptional regulation of mesodermal and cardiac genes. This study aimed to examine the contribution of LTCCs and the effect of nifedipine on the commitment of pluripotent stem cells toward the cardiac lineage in vitro. The murine embryonic stem (ES, cell line D3) and induced pluripotent stem (iPS, cell clone 09) cells were differentiated into enhanced green fluorescence protein (EGFP) expressing spontaneously beating cardiomyocytes (CMs). Early treatment of differentiating cells with 10 µM nifedipine led to a significant inhibition of the cardiac mesoderm formation and cardiac lineage commitment as revealed by gene regulation
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Pain. Pancreatitis. Abstract. Endoscopic retrograde cholangiopancreatography (ERCP) is complicated by acute pancreatitis in up to. Digestion. 1993;54(2):105-11. Prospective randomized trial of the effect of nifedipine on pancreatic irritation after endoscopic retrograde. The aim of this randomized, placebo-controlled trial was is zoloft a generic xanax determine whether the calcium channel blocker nifedipine prevents post-ERCP pancreatitis.. We excluded other causes of acute pancreatitis by clinical history, serum Keywords: Pancreatitis • Nifedipine • Acetaminophen • Poisoning • Hemofiltration. ...
The present study highlights the following novel findings on the mechanisms responsible for the normalization of endothelial dysfunction by calcium antagonists. (1) The calcium antagonist nifedipine indirectly upregulates SOD activity and expression in ECs through activation of adjacent VSMCs. (2) VEGF released from VSMCs is involved in the mechanism underlying the upregulation of endothelial SOD activity by nifedipine. (3) Nifedipine stimulates the release of VEGF from VSMCs through activation of the bradykinin B2 receptor. (4) Upregulation of endothelial SOD by nifedipine results in the enhancement of NO production from ECs.. Calcium antagonists are widely used in the treatment of hypertension and angina pectoris. Recent evidence suggests that these drugs improve clinical outcome in patients with certain cardiovascular diseases.12,13⇓ It is noteworthy that calcium antagonists have been shown to normalize endothelial dysfunction in many cardiovascular diseases,14 because endothelial ...
Sublingual nifedipine has previously been used in hypertensive emergencies. This was found to be dangerous, and has been abandoned. Sublingual nifedipine causes blood-pressure lowering through peripheral vasodilation. It can cause an uncontrollable decrease in blood pressure, reflex tachycardia, and a steal phenomenon in certain vascular beds. There have been multiple reports in the medical literature of serious adverse effects with sublingual nifedipine, including cerebral ischemia/infarction, myocardial infarction, complete heart block, and death. As a result of this, the FDA reviewed all data regarding the safety and efficacy of sublingual nifedipine for hypertensive emergencies in 1995, and concluded that the practice should be abandoned because it was neither safe nor efficacious. An exception to the avoidance of this practice is in the use of nifedipine in the treatment of hypertension associated with autonomic dysreflexia in spinal cord injury ...
It is known that various DHP calcium antagonists enhance the NO release from endothelial cells.14 15 16 17 18 19 Using an NO-sensitive electrode, we previously demonstrated that nifedipine in the micromolar and submicromolar concentration ranges stimulates the NO release from the native endothelium.33 34 These findings were obtained after acute exposure to DHP calcium antagonists. Therefore, we investigated whether (1) a long-term treatment (48 hours, entire passage 2) of porcine endothelial cell cultures with nifedipine resulted in a similarly altered NO release and (2) an increased formation and/or an impaired inactivation of NO might be involved by measuring the ecNOS (NOS isoform III) mRNA and protein expression and the antioxidative potency of nifedipine, respectively.. In contrast to the short-term measurements during long-term treatment, nifedipine was not present in the buffer during the antioxidative and NO experiments.. We could demonstrate that treatment with nifedipine (concentration ...
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In a double-blind, randomized crossover study, the daily administration of 30 to 90 mg of nifedipine lowered blood pressure in a dose-related fashion in 14 patients already taking a beta receptor blocker and diuretic. The duration of the hypotensive response to 20 mg of nifedipine in capsule form, giving as a step-three drug to five of these patients, was six to eight hours. A survey of 122 patients with resistant hypertension treated long-term with nifedipine and a control group of 102 similar patients treated with hydralazine revealed that nifedipine at an average dose of 40 mg daily caused a fall in blood pressure similar to that achieved with hydralazine in a dose of 86 mg daily. The side effect profile of both drugs was also similar. Nifedipine may be a useful alternative to existing step-three antihypertensive drugs.
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Quite unexpectedly, it was found that the asymmetrical nonlinear behavior of ΔVm was reversed by application of Ca2+ channel blocker nifedipine. As seen in Figures 2⇑ and 4⇑, nifedipine caused a strong increase in the magnitude of the maximal positive ΔVm, but either no change (wide strands) or a decrease (narrow strands) of the negative ΔVm. In both cases, the ΔVm asymmetry was strongly reduced.. As we argue below, the effect of nifedipine on the ΔV−m in the narrow strands was not direct but was mediated via electrotonic interaction with the area of positive ΔVm. Thus, the key effect of nifedipine was the increase of the ΔV+m. In general, 2 different explanations for this effect are possible. First, nifedipine could directly affect the ΔV+m. Second, similarly to the effect of 4-AP, nifedipine could affect APA, thus changing the optically measured ΔV+m. Although it is known that nifedipine can slightly reduce APA in neonatal rat myocytes,15 this effect does not explain the ...
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Nifedipine is completely absorbed after oral administration. Plasma drug concentrations rise at a gradual, controlled rate after a Nifedipine Extended-release Tablet dose and reach a plateau at approximately six hours after the first dose. For subsequent doses, relatively constant plasma concentrations at this plateau are maintained with minimal fluctuations over the 24-hour dosing interval. About a fourfold higher fluctuation index (ratio of peak to trough plasma concentration) was observed with the conventional immediate-release nifedipine capsule at t.i.d. dosing than with once daily Nifedipine Extended-release Tablet. At steady-state the bioavailability of the Nifedipine Extended-release Tablet is 86% relative to immediate-release capsules. Administration of the Nifedipine Extended-release Tablet in the presence of food slightly alters the early rate of drug absorption, but does not influence the extent of drug bioavailability. Markedly reduced GI retention time over prolonged periods (i.e., ...
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We investigated the effect of the calcium channel antagonist nifedipine on the induction of nitric oxide synthase (NOS) by bacterial endotoxin (lipopolysaccharide; LPS) in J774.2 macrophages, in cultured rat aortic smooth muscle cells and in a rat model of endotoxin shock. Stimulation by LPS for 24 hr increased nitrite accumulation in the supernatant of both cell types. NOS induction accounts for this nitrite accumulation, as both NG-methyl-L-arginine and cycloheximide reduced nitrite production in both cell types. Dexamethasone inhibited LPS-stimulated nitrite production in macrophages, but not in rat aortic smooth muscle cells. Nifedipine inhibited the production of nitrite in these LPS-treated cell types, with a more pronounced effect on macrophages. However, nifedipine did not inhibit the production of nitrite in J774.2 cells in which NOS had already been induced by prior exposure to LPS, and any possible further induction was inhibited by cycloheximide. In anesthetized rats subjected to ...
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The present study provides 2 major new findings. First, in contrast to its peripheral effects, centrally administered nifedipine decreases RSNA and HR in conscious SHR. Second, these sympathoinhibitory effects of nifedipine are enhanced in SHR on high versus regular sodium intake.. Dihydropyridine-sensitive, low-voltage-activated calcium channels have been demonstrated in rat brain neurons freshly isolated from regions such as the ventromedial hypothalamus.6 The role of the different types of calcium channels in neuronal synaptic transmission has not been clarified. In rat hippocampal cells,7 during neuronal activation postsynaptic or presynaptic Ca2+ entry involves the activation of the P/Q-, L-, or N-type Ca2+ channels but not the T-type Ca2+ channels. Unless dissolved in certain solvents such as dimethylsulfoxide,15 nifedipine blocks only L-type channels and has no effects on T-type channels in neuronal cells.8 15 In the present study nifedipine was dissolved in a vehicle containing no ...
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A form of human hepatic microsomal cytochrome P-450 (P450hA7) with subunit Mr 50,400 has been purified from an epileptic who had been receiving long-term treatment with anticonvulsant drugs. P450hA7 metabolized the immunosuppressant drug cyclosporin A and the dihydropyridine calcium channel antagonist nifedipine, but did not metabolize a similar dihydropyridine drug, nicardipine, nor a series of alkoxyresorufin model substrates. The hepatic microsomal concentration of P450hA7 was higher in five individuals who had been receiving long-term anticonvulsant treatment than in any of 21 individuals who had not been similarly treated. The mean P450hA7 concentration in the treated individuals was 5-fold higher than the mean concentration in the untreated individuals. It is concluded that P450hA7 is a member of the cytochrome P450III family which is induced by anticonvulsant drugs in man. ...
Early treatment with nifedipine in patients with AMI did not appear to reduce infarct size as determined by enzyme level. Although blood pressure reduction was achieved with nifedipine, there was no observed clinical benefit. In a similar fashion, the Trent nifedipine study observed no mortality benefit from nifedipine after myocardial infarction. The investigators concluded that there was no reason to recommend general treatment with calcium antagonists to reduce infarct size.. ...
TY - JOUR. T1 - Comparison of myocardial protection with nifedipine and potassium. AU - Magee, P. G.. AU - Flaherty, J. T.. AU - Bixler, T. J.. AU - Glower, D.. AU - Gardner, T. J.. AU - Bukley, B. H.. AU - Gott, V. L.. PY - 1979/1/1. Y1 - 1979/1/1. N2 - Nifedipine, a slow-channel calcium blocker, is thought to provide useful myocardial protection during prolonged total ischemia and reperfusion. An isolated, isovolumic, feline heart model was used to assess the effectiveness of nifedipine in both cardioplegic (100 μg/10 ml) and noncardioplegic (10 μg/10 ml) doses for providing myocardial preservation during 90 minutes of hyperthermic ischemic arrest and 45 minutes of normothermic reperfusion. Use of nifedipine was compared to hypothermia (27°C) alone and to hypothermia with potassium cardioplegia. Ventricular function was assessed by recovery of isovolumic left ventricular developed pressure and dP/dt. Myocardial carbon dioxide tension (PCO2) and myocardial oxygen tension (PO2) were measured ...
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To compare renal function (51Cr-EDTA clearance) 48 hours post open-heart surgery (coronary bypass or valve surgery) in patients with impaired renal function after randomization to either nifedipine infusion at start of surgery and the following 24 hours or placebo (0.9% saline infusion). Study hypothesis is that nifedipine has a prophylactic effect on decline in renal function ...
INSIGHT and NORDIL add to the acronymic litany of recent trials addressing pharmacotherapy of hypertension-this litany consists of multiple trials with multiple comparisons spawned by multiple drugs from multiple classes with multiple actions. With the addition of the INSIGHT trial and NORDIL study, we have 10 completed long-term trials that compare calcium antagonists with other antihypertensive drugs. Such trials that evaluate morbidity and mortality effects of calcium antagonists have variable findings that are difficult to interpret. • None were large enough to reliably detect moderate differences (10% to 15%) in such clinically important outcomes as MI (1). • BP control with monotherapy was not achieved in as many as one third to one half of trial participants, depending on baseline and target BP levels. • Comparisons among agents were usually complicated by the addition of second and third drugs. • In large trials, such as INSIGHT and the Swedish Trial in Old Patients (STOP-2) (2), ...
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The signaling pathways following histamine H3 receptor activation by (R)alpha-methylhistamine (MHA) have been examined in the isolated guinea pig duodenum, in which selective excitation of cholinergic neurons was induced by electrical field stimulation (EFS). The effect of MHA on electrically evoked contractions was compared with that induced by the alpha-2 adrenoceptor agonist clonidine (CLON). The inhibitory effect of MHA on EFS-induced contractions was significantly reduced by increasing CA++ content in the nutrient fluid from 2.5 to 5 mM and by the Ca++ agonist Bay K 8644 (10(-8) M); conversely, the effect of MHA was significantly enhanced by lowering Ca++ content in the medium (from 2.5 to 1.25 mM) and by the N-type Ca++ channel blocker omega-conotoxin (CTX) (10(-8) M). The L-type Ca++ channel blocker nifedipine (NIF) (10(-7) M) did not modify the effect of MHA, although it significantly reduced both EFS- and exogenous acetylcholine (ACH)-induced contractions. Similar to MHA, the inhibitory ...
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Except that the aggressive care of hypertensive emergency may make people worse, not better, and is too often invoked with delusions of benefit. When I was an intern, there was a tried and true recipe to handle this vital sign when it bothered the nurses. If the systolic pressure was too high, the contents of a 25mg nifedipine capsule could be aspirated into a small syringe and delivered sublingually. The result was a predictable, beautiful lowering of the systolic pressure over the next 30 minutes and at the 1 hour mark we had nearly always achieved the prescribed 25% MAP reduction. Seen this tried and true method lately? No, since it was realized that there was a downstream 6% stroke rate. The FDA rejected this use of nifedipine to rapidly lower BP in 1985, but in 1996 it was still a common choice: Today, IV pushes of vasoactive agents for no clinical indication still persist. I find our collective lack of memory… troubling. Note the use of the term pseudoemergency in the above JAMA ...
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Patients presenting between 24-34 weeks gestation diagnosed with preterm labor who grant consent will be randomized by the pharmacy to receive oral nifedipine or oral indomethacin. Both the patient and primary medical provider will be blinded to the identity of the study drug. An abdominal ultrasound will be performed in the labor and delivery unit prior to the administration of the tocolytic in order to assess fetal position and fluid level, and to document fetal cardiac activity and movement, and will be repeated at 48 hours post-randomization. Following randomization, the patient will be given either 50 mg oral indomethacin with two pills of placebo, or 3 pills each containing 10 mg oral nifedipine for a total of 30 mg. The patients will then receive either 25 mg of oral indomethacin every 6 hours for 48 hours, or 20 mg of oral nifedipine every 6 hours for 48 hours. Tocolysis beyond 48 hours will not be used. Antibiotics and steroids for fetal lung maturity will be administered as per ...
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Effects of a new dihydropyridine calcium antagonist on vascular smooth muscles, cardiac muscles and [3H]-nitrendipine binding.: The effects of methyl 2,6-dimeth
TY - JOUR. T1 - Specific binding of the calcium antagonist [3H]nitrendipine to subcellular fractions isolated from canine myocardium. Evidence for high affinity binding to ryanodine-sensitive sarcoplasmic reticulum vesicles. AU - Williams, L. T.. AU - Jones, L. R.. PY - 1983/1/1. Y1 - 1983/1/1. N2 - [3H]Nitrendipine, a potent calcium antagonist, was used to determine the number of binding sites for dihydropyridine calcium antagonists in well characterized subcellular fractions prepared from canine myocardium. The distribution of high affinity [3H]nitrendipine binding sites was compared with the distribution of sarcolemma, sarcoplasmic reticulum, and mitochondrial markers. The highest density of [3H]nitrendipine binding sites (1.5 pmol/mg of protein) was in a subfraction enriched in ryanodine-sensitive sarcoplasmic reticulum vesicles. In contrast, the density of [3H]nitrendipine binding sites in the ryanodine-insensitive vesicles was less than 10% of that present in the ryanodine-sensitive ...
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The dinoflagellate toxin maitotoxin (MTX) elicited a sustained increase of [Ca2+]i in C6 glioma cells. This response was inhibited by SK&F 96365, a blocker of receptor-mediated calcium entry. In C6 cells, endothelin-1 elicited a rapid but transient increase in [Ca2+]i, followed by a smaller sustained increase. SK&F 96365 inhibited the sustained increase in [Ca2+]i. In both C6 glioma cells and RIN insulinoma cells, MTX elicited a marked influx of 45Ca2+. SK&F 96365 inhibited MTX-induced 45Ca2+ influx by 95% at 30 microM. The L-type calcium channel blocker nifedipine, even at 10 microM, inhibited MTX-induced calcium uptake by only 20% in RIN cells and by only 10% in C6 cells. MTX elicited calcium-dependent phosphoinositide breakdown in both C6 and RIN cells. In both cell lines, the MTX-induced phosphoinositide breakdown was inhibited by 90% by SK&F 96365 at 30 microM. Endothelin-1 and carbamylcholine elicited phosphoinositide breakdown in C6 cells and RIN cells, respectively. The stimulations were ...
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Narita, M.; Kurihara, T.; Murano, K.; Usami, M.; Honda, M.; Kanao, K., 1984: Effects of nifedipine on left ventricular systolic and diastolic functions in left ventricular hypertrophy
1. In 27 severe primary hypertensive patients nifedipine (10 mg), administered orally, induced prompt (-21% of control at 30 min) and persistent (-17% at 120 min) fall of mean arterial pressure mediated through reduction of peripheral vascular resistance with rise of cardiac output.. 2. The sublingual route (nine cases) showed more rapid onset of action and equal antihypertensive effectiveness.. 3. In five patients with hypertensive crisis and acute left ventricular failure, the drug strikingly reduced systemic and pulmonary arterial pressures and relieved pulmonary oedema.. 4. Prompt efficacy, ease of administration, absence of important side effects indicate that nifedipine may be a useful therapeutic agent in severe hypertension and in critical conditions that require rapid lowering of blood pressure.. ...
Results: Depolarization in HCEC-SV40 led to Ba2+ inward currents similar to L-type Ca2+ channel currents. Extracellular application of b-FGF (basic fibroblast growth factor) (10 ng/ml) led to an increase in intracellular Ca2+ concentration (from 115 ± 3 nM; n = 5 to 153 ± 3 nM; n = 6). This effect was at higher levels in HCEC-SV40 (from 108 ± 3 nM to 177 ± 21 nM; both n = 4). In addition, a-FGF (acidic-FGF) (10 ng/ml) led to a similar effect in HCEC-SV40, which was disrupted by the specific L-type channel blocker nifedipine (5 µM). In contrast, inhibition of FGF receptors by tyrosine kinase inhibitors led to a decreased magnitude of capacitative Ca2+ entry (CCE ...
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Vignaux, O.; Allanore, Y.; Meune, C.; Pascal, O.; Duboc, D.; Weber, S.; Legmann, P.; Kahan, A., 2005: Evaluation of the effect of nifedipine upon myocardial perfusion and contractility using cardiac magnetic resonance imaging and tissue Doppler echocardiography in systemic sclerosis
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Although extensive work has been conducted to elucidate second messenger/protein kinase cascades involved in serotonergic modulation of the sensory neuron of Aplysia, little is known about the interaction between these cascades. Previously, it was suggested that the cAMP/PKA cascade was necessary for the 5-HT-induced activation of the PKC pathway (Goldsmith and Abrams, 1991). Goldsmith and Abrams (1991) reported that 9-(tetrahydro-2-furyl)adenine (TFHA; an inhibitor of adenylyl cyclase) inhibited 5-HT-induced facilitation of depressed synapses, an effect believed to be dependent on PKC (Braha et al., 1990; Ghirardi et al., 1992). The suggested serial interaction of cAMP/PKA and PKC, however, seems to contradict several recent findings that 5-HT-induced PKC-dependent effects are not inhibited by cAMP antagonists. For example, 5-HT-induced increases in spontaneous miniature EPSPs or 5-HT-induced increases in nifedipine-sensitive Ca2+ current were not blocked by a cAMP antagonist Rp-cAMP but were ...
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OBJECTIVE--To investigate the mechanism of calcium antagonist mediated cytoprotection against the damaging effects of adrenaline in vivo on cardiac myocytes and human endothelial cells from the umbilical vein. METHODS--Human endothelial cells cultured from the umbilical vein and isolated rat cardiac myocytes were treated with plasma from rats given adrenaline 30 minutes previously with pretreatment with calcium antagonists and without. The effect on indices of cell damage that suggest oxidation stress was determined. RESULTS--Pretreatment of rats with calcium antagonists before adrenaline administration largely inhibited the cytotoxic effects of their plasma on the two target cells used. Plasma taken from animals not pretreated with calcium antagonists caused release of oxidised glutathione from cells, a fall in intra-cellular reduced glutathione concentration, a fall in ATP production, and release of angiotensin converting enzyme from the endothelial cells. CONCLUSION--Calcium antagonists ...
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"Nifedipine". DrugBank. 16 October 2018. Retrieved 16 October 2018. "Chloroquine - MeSH". NCBI. 16 October 2018. Retrieved 16 ... is the prototype ethanolamine antihistamine Nifedipine is the prototype dihydropyridine calcium channel blocker Chloroquine is ...
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Nifedipine. Medicines administered to the mother[edit]. *Dexamethasone. *Tranexamic acid. Medicines administered to the neonate ...
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Most frequent side effects are nausea, orthostatic hypotension, headaches, and vomiting through stimulation of the brainstem vomiting centre.[9] Vasospasms with serious consequences such as myocardial infarction and stroke that have been reported in connection with the puerperium, appear to be extremely rare events.[10] Peripheral vasospasm (of the fingers or toes) can cause Raynaud's Phenomenon. Bromocriptine use has been anecdotally associated with causing or worsening psychotic symptoms (its mechanism is in opposition of most antipsychotics, whose mechanisms generally block dopamine).[11] Pulmonary fibrosis has been reported when bromocriptine was used in high doses for the treatment of Parkinson's disease.[12] Use to suppress milk production after childbirth was reviewed in 2014 and it was concluded that in this context a causal association with serious cardiovascular, neurological or psychiatric events could not be excluded with an overall incidence rate estimated to range between 0.005% ...
InChI=1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1 ...
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It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.[4] Magnesium sulfate is a common mineral pharmaceutical preparation of magnesium, commonly known as Epsom salt, used both externally and internally. Magnesium sulfate is highly water-soluble and solubility is inhibited with lipids typically used in lotions. Lotions often employ the use of emulsions or suspensions to include both oil and water-soluble ingredients. Hence, magnesium sulfate in a lotion may not be as freely available to migrate to the skin nor to be absorbed through the skin, hence both studies may properly suggest absorption or lack thereof as a function of the carrier (in a water solution vs. in an oil emulsion/suspension). Temperature and concentration gradients may also be contributing factors to absorption.[5] Externally, magnesium sulfate paste is used to treat skin inflammations such as small boils or localised infections. Known in the UK as 'drawing paste' it ...
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... nifedipine (INN) Nifehexal (Hexal Australia) [Au]. Redirects to nifedipine. nifekalant (INN) nifenalol (INN) nifenazone (INN) ...
... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
However, nifedipine has never been approved by the FDA for treatment of urticaria pigmentosa. Another mast cell stabilizer ... At least one clinical study suggested that nifedipine, a calcium channel blocker used to treat high blood pressure, may reduce ... included a patient with symptomatic urticaria pigmentosa who responded to nifedipine at dose of 10 mg po tid. ... 1] Fairley JA, Pentland AP, Voorhees JJ (1984). "Urticaria pigmentosa responsive to nifedipine". J. Am. Acad. Dermatol. 11 (4 ...
Giffin, JP; Cottrell, JE; Hartung, J; Shwiry, B (1983). "Intracranial Pressure During Nifedipine-induced hypotension". ...
As with prevention, the standard medication once a climber has developed HAPE is nifedipine, although its use is best in ... The most studied and preferred medication for prevention of HAPE is nifedipine, a pulmonary vasodilator which prevents the ... October 1991). "Prevention of high-altitude pulmonary edema by nifedipine". The New England Journal of Medicine. 325 (18): 1284 ... Salmeterol is considered an adjunctive therapy to nifedipine, though only in highly susceptible climbers with clearly ...
"NIFEDIPINE EXTENDED RELEASE- nifedipine tablet, extended release". DailyMed. 2012-11-29. Retrieved 2019-02-01. Kotlyar M, ...
"NIFEDIPINE EXTENDED RELEASE- nifedipine tablet, extended release". DailyMed. 2012-11-29. Retrieved 2019-02-01. Drug ... In vitro and in vivo data indicate that nifedipine can inhibit the metabolism of drugs that are substrates of CYP3A, thereby ... Nifedipine is a vasodilator, and coadministration of other drugs affecting blood pressure may result in pharmacodynamic ... Inhibitors and inducers of CYP3A can impact the exposure to nifedipine and consequently its desirable and undesirable effects. ...
... nifedipine 7, amlodipine 5, and verapamil 0.2. Felodipine is a member of the 1,4-dihydropyridine class of calcium channel ... the drug entered a very crowded market the included the other calcium channel blockers nifedipine, verapamil, nicardipine, and ...
Kupferminc M, Lessing JB, Yaron Y, Peyser MR (December 1993). "Nifedipine versus ritodrine for suppression of preterm labour". ...
Dihydropyridines including felodipine (Plendil), nicardipine (Cardene), nifedipine, nisoldipine (Sular) and nitrendipine ( ... "Interactions of Citrus Juices with Felodipine and Nifedipine." However, the effect only became well-publicized after being ... "Interaction of citrus juices with felodipine and nifedipine". The Lancet. 337 (8736): 268-269. doi:10.1016/0140-6736(91)90872-m ...
Yui-Ming Lam; Hung-Fat Tse; Chu-Pak Lau (April 2001). "Continuous Calcium Chloride Infusion for Massive Nifedipine Overdose". ...
Sublingual nifedipine is not recommended in hypertensive urgencies. This is because nifedipine can cause rapid decrease of ... There is also lack of evidence on the benefits of nifedipine in controlling hypertension. Acute administration of drugs should ...
The dihydropyridine derivative isradipidine can replace nifedipine for some uses of calcium channel blocking and does not ... Westbrook, P (1997). "Regression of nifedipine-induced gingival hyperplasia following switch to a same class calcium channel ... Butler RT, Kalkwarf KL (1987). "Drug-induced gingival hyperplasia: phenytoin, cyclosporine, and nifedipine". Journal of the ... antihypertensives such as nifedipine, amlodipine, and verapamil). The dihydropyridine derivative isradipidine can replace ...
Nifedipine, a vasodilator, may help in some cases. Vasodilation may reduce pain, facilitate healing, and prevent recurrences. ... nifedipine in chilblains: A clinical trial". Indian Journal of Dermatology, Venereology and Leprology. 69 (3): 209-11. PMID ... Rustin, M.H.A.; Newton, Julia A.; Smith, N.P.; Dowd, Pauline M. (2006). "The treatment of chilblains with nifedipine: the ...
Ansah, Twum-Ampofo; Wade, Littleton H.; Kopsombut, Prapaporn; Shockley, Dolores C. (2002-02-01). "Nifedipine potentiates the ...
... also has a longer half-life than nifedipine. Nicardipine was approved by the FDA in December 1988. The patent for ... Its mechanism of action and clinical effects closely resemble those of nifedipine and the other dihydropyridines (amlodipine, ...
Mohamed Ismail NA, Ibrahim M, Mohd Naim N, Mahdy ZA, Jamil MA, Mohd Razi ZR (September 2008). "Nifedipine versus terbutaline ...
Source for information on nifedipine: A Dictionary of Nursing dictionary. ... nifedipine (ny-fed-i-peen) n. a calcium-channel blocker used to prevent angina and treat hypertension and Raynauds phenomenon ... nifedipine (ny-fed-i-peen) n. a calcium-channel blocker used to prevent angina and treat hypertension and Raynauds phenomenon ... www.encyclopedia.com/caregiving/dictionaries-thesauruses-pictures-and-press-releases/nifedipine ...
Nifedipine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Nifedipine is used to treat high blood pressure and to control angina (chest pain). Nifedipine is in a class of medications ... Continue to take nifedipine even if you feel well. Do not stop taking nifedipine without talking to your doctor. Your doctor ... Before taking nifedipine,. *tell your doctor and pharmacist if you are allergic to nifedipine, any other medications, or any of ...
Nifedipine for epilepsy? Br Med J (Clin Res Ed) 1988; 296 :1069 ... Nifedipine for epilepsy?. Br Med J (Clin Res Ed) 1988; 296 doi ...
A list of US medications equivalent to Nifedipine is available on the Drugs.com website. ... Nifedipine is a medicine available in a number of countries worldwide. ... Nifedipine. In the US, Nifedipine (nifedipine systemic) is a member of the drug class calcium channel blocking agents and is ... Béta Adalate (Nifedipine and Atenolol). Bayer Santé, France. *Beta-Adalat (Nifedipine and Atenolol). Bayer, United Kingdom; ...
Topical nifedipine has been shown to be as effective as topical nitrates for anal fissures. Nifedipine is also used in high- ... In India, Nifedipine is manufactured by JB Chemicals, and comes in brands Nicardia Retard (Nifedipine 10mg, 20mg tablets) as ... Nifedipine is a calcium channel blocker. Although nifedipine and other dihydropyridines are commonly regarded as specific to ... Nifedipine was patented in 1967, and approved for use in the United States in 1981. It is on the World Health Organizations ...
A list of US medications equivalent to Nifedipine Teva is available on the Drugs.com website. ... Nifedipine Teva is a medicine available in a number of countries worldwide. ... Nifedipine Teva may be available in the countries listed below.. Ingredient matches for Nifedipine Teva. Nifedipine. Nifedipine ...
NIFEDIPINE (nye FED i peen) is a calcium-channel blocker. It affects the amount of calcium found in your heart and muscle cells ... Nifedipine capsules. What is this medicine?. NIFEDIPINE (nye FED i peen) is a calcium-channel blocker. It affects the amount of ... an unusual or allergic reaction to nifedipine, other medicines, foods, dyes, or preservatives ...
... nifedipine, nifedipine (medication), Nifedipine [2], NIFEDIPINE, Nifedipine [Chemical/Ingredient], NIFEdipine, Nifedipine [2] ( ... Write for generic Nifedipine ER to allow pharmacist to substitute between multiple similar ER preparations. *(2016) Presc Lett ... These images are a random sampling from a Bing search on the term "Nifedipine." Click on the image (or right click) to open the ... Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, ...
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Find out what health conditions may be a health risk when taken with nifedipine oral ... nifedipine ER. Common Brand(s): Procardia XL Generic Name(s): nifedipine View Free Coupon ... Who should not take NIFEDIPINE ER? The following conditions are contraindicated with this drug. Check with your physician if ... Should I avoid certain foods while taking nifedipine ER? * What should I know regarding pregnancy, nursing and administering ...
nifedipine synonyms, nifedipine pronunciation, nifedipine translation, English dictionary definition of nifedipine. n. A ... nifedipine. Also found in: Thesaurus, Medical, Wikipedia.. Related to nifedipine: atenolol. ni·fed·i·pine. (nī-fĕd′ə-pēn′). n. ... Nifedipine - definition of nifedipine by The Free Dictionary https://www.thefreedictionary.com/nifedipine ... but an increase in perinatal mortality in those treated with nifedipine is raising concerns about its safety.. Nifedipine upped ...
Does nifedipine ameliorate cyclosporin A nephrotoxicity? Br Med J (Clin Res Ed) 1987; 295 :851 doi:10.1136/bmj.295.6602.851-b ... Does nifedipine ameliorate cyclosporin A nephrotoxicity?. Br Med J (Clin Res Ed) 1987; 295 doi: https://doi.org/10.1136/bmj. ...
Nifedipine Poisoning in a Child. Thomas G. Wells, Charles J. Graham, M. Michele Moss and Gregory L. Kearns ... Complications related to nifedipine intoxication included the development of pulmonary edema and possible infarction in the ... Massive nifedipine overdose in infants represents a potentially life-threatening event that requires prompt medical attention. ... Reported cases of nifedipine intoxication were reviewed and therapeutic interventions Received for publication Jan 23, 1989; ...
The composition of this invention can increase the bioavailability of nifedipine and makes it possible to provide a nifedipine- ... a mixture of nifedipine, at least one 1st(b) substance selected from polyvinyl pyrrolidone, urea, citric acid mannitol, ... or a mixture of nifedipine, the 1st(b) substance, the 2nd substance and calcium lactate. ... A novel nifedipine-containing solid pharmaceutical preparation composition comprising a mixture of nifedipine and at least one ...
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Oral Nifedipine and Atenolol Are Comparable Agents. InPharma volume 545, page11(1986)Cite this article ... Oral Nifedipine and Atenolol Are Comparable Agents. Inpharma Wkly. 545, 11 (1986). https://doi.org/10.1007/BF03299482 ...
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Abstract The interaction mechanism between nifedipine (NDP) and pepsin (PEP) at 298, 310, and 318 K was studied by various ... Pepsin Nifedipine Spectroscopy Interaction Molecular docking This is a preview of subscription content, log in to check access. ... The interaction mechanism between nifedipine (NDP) and pepsin (PEP) at 298, 310, and 318 K was studied by various spectroscopic ...
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  • nifedipine (ny- fed -i-peen) n. a calcium-channel blocker used to prevent angina and treat hypertension and Raynaud's phenomenon. (encyclopedia.com)
  • An exception to the avoidance of this practice is in the use of nifedipine for the treatment of hypertension associated with autonomic dysreflexia in spinal cord injury. (wikipedia.org)
  • Nifedipine is used to treat hypertension (high blood pressure). (healthline.com)
  • Nifedipine is used to lower blood pressure in people with hypertension. (healthline.com)
  • Nifedipine is used to treat hypertension and chronic stable angina. (drugbank.ca)
  • Nine patients with uncomplicated essential hypertension received, according to a randomized sequence, captopril (25 mg three times daily), nifedipine (10 mg three times daily), and both drugs for 1 week, with each treatment period separated by a 1-week interval during which a placebo was given. (ahajournals.org)
  • INTRODUCTION: Nifedipine, a dihydropyridine Ca 2+ channel antagonist, is a potent vasodilator [1] and is used to treat hypertension, coronary and other vasospasm. (lww.com)
  • Nifedipine (Adalat, Procardia, C 17 H 18 N 2 O 6 , MW 346.33) is a 1,4-dihydropyridine-derivative calcium channel blocker used in the management of Prinzmetal (variant) angina and chronic stable angina pectoris, hypertension, Raynaud phenomenon, preterm labor, and acute myocardial infarction. (uspharmacist.com)
  • To the editor: Rubin and associates (1) suggest that treatment with nifedipine may be useful in managing patients with primary pulmonary hypertension. (annals.org)
  • Nifedipine and barnidipine act as calcium channel blockers, and are widely prescribed for pressure control of prehypertension and stage 1 hypertension. (bioportfolio.com)
  • Despite these differences, nifedipine reduced BP to a similar extent in each group, with efficacy dependent on cardiovascular risk factors such as hypertension grade and age. (dovepress.com)
  • Good rates of BP control were observed with nifedipine in patients with moderate-to-severe hypertension and high added risk. (dovepress.com)
  • 1. The effects of chronic dietary salt-loading and nifedipine therapy on hypertension-prone (SBH), -resistant (SBN) and parental (SB) Sabra rats were investigated. (portlandpress.com)
  • Sublingual nifedipine in acute severe hypertension. (bmj.com)
  • Sublingual nifedipine was used for the treatment of acute severe hypertension in 12 children with renal disease. (bmj.com)
  • Adalat (Nifedipine) is commonly prescribed for treatment of hypertension (high blood pressure) and angina (chest pain). (medformula.com)
  • 4. Prompt efficacy, ease of administration, absence of important side effects indicate that nifedipine may be a useful therapeutic agent in severe hypertension and in critical conditions that require rapid lowering of blood pressure. (clinsci.org)
  • Nifedipine is used to lower (hypertension) and to treat angina (midsection torment). (medicinesmexico.com)
  • A 5 year old boy, suffering from hyperinsulinemic hypoglycaemia and arterial hypertension secondary to polycystic kidney disease, was given nifedipine (0,3 mg/kg/TDS) to treat his high blood pressure. (bestbets.org)
  • Nifedipine GITS reduced by 13% the combined incidence of the primary endpoint (all-cause mortality, MI, refractory angina, new overt heart failure, stroke, and peripheral revascularization) in the patients with hypertension. (eshonline.org)
  • Zydus Pharmaceuticals (USA) Inc has received final approval from the US health regulator to market Nifedipine extended release tablets used in treatment of hypertension and chest pain. (business-standard.com)
  • Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT). (acpjc.org)
  • In patients with hypertension who are at high risk for cardiovascular (CV) events, is long-acting nifedipine, a calcium-channel blocker, as effective as co-amilozide (hydrochlorothiazide and amiloride) for preventing CV and cerebrovascular mortality and morbidity? (acpjc.org)
  • Nifedipine and co-amilozide were equally effective for preventing cardiovascular and cerebrovascular mortality and morbidity in high-risk patients with hypertension. (acpjc.org)
  • To compare the effects of an angiotensin-converting enzyme (ACE) inhibitor (cilazapril), a β-blocker (atenolol), and a calcium channel blocker (nifedipine retard) on the quality of life of patients with mild-to-moderate hypertension. (acpjc.org)
  • Nifedipine oral tablet is a prescription drug that's available as the brand-name drugs Adalat CC, Afeditab CR, and Procardia XL . (healthline.com)
  • Nifedipine immediate-release capsules are available as the brand-name drug Procardia . (healthline.com)
  • What are the possible side effects of nifedipine (Procardia)? (rxlist.com)
  • Procardia (nifedipine) Drug Side Effects, Interactions, and Medication Information on eMedicineHealth. (emedicinehealth.com)
  • What is nifedipine (Procardia)? (emedicinehealth.com)
  • What is the most important information I should know about nifedipine (Procardia)? (emedicinehealth.com)
  • What should I discuss with my healthcare provider before taking nifedipine (Procardia)? (emedicinehealth.com)
  • How should I take nifedipine (Procardia)? (emedicinehealth.com)
  • Adalat (nifedipine) is a calcium channel blocker like Procardia and in the same class as norvasc. (healthtap.com)
  • Adalat is nifedipine, which is also marketed as procardia. (healthtap.com)
  • I was on procardia (nifedipine) for 2 weeks to stop labor. (healthtap.com)
  • Pregnant just stopped taking procardia (nifedipine) -- any baby effects? (healthtap.com)
  • No data are given by Rubin and associates on the effect of nifedipine on arterial Po 2 , alveolar-arterial oxygen tension difference (A-aDo 2 ), or calculated shunt fraction (Qs/Qt). (annals.org)
  • To evaluate the effect of nifedipine on mortality. (acc.org)
  • This study aimed to examine the contribution of LTCCs and the effect of nifedipine on the commitment of pluripotent stem cells toward the cardiac lineage in vitro.This was accompanied by the inhibition of spontaneously occurring Ca(2+) transient and reduction of LTCCs current density (I(CaL)) of differentiated CMs. (nih.gov)
  • This study aimed to examine the contribution of LTCCs and the effect of nifedipine on the commitment of pluripotent stem cells toward the cardiac lineage in vitro. (nih.gov)
  • Thus, this study investigates the effects of nifedipine on cardiovascular function in sevoflurane anesthetized chronically instrumented dogs with and without blockade of the autonomic nervous system (ANS). (lww.com)
  • Haemodynamic effects of nifedipine and propranolol in patients with hypertrophic obstructive cardiomyopathy. (bmj.com)
  • To test this hypothesis, we investigated the effects of nifedipine on iron content and expression of TfR1, DMT1 and ferroportin1 (Fpn1) in WKPT-0293 Cl.2 cells of the S1 segment of the proximal tubule in rats, using a graphite furnace atomic absorption spectrophotometer and Western blot analysis, respectively. (frontiersin.org)
  • These findings suggest that the nifedipine-induced increase in cell iron may mainly be due to the corresponding increase in TfR1 and DMT1 expression and also imply that the effects of nifedipine on iron transport in proximal tubule cells can not explain the increase in urinary iron excretion. (frontiersin.org)
  • Effects of nifedipine on gastric acid secretion and gastrin release in man. (bmj.com)
  • As anyone experienced side effects of nifedipine for labor? (healthtap.com)
  • Nifedipine GITS (Gastrointestinal Therapeutic System) tablet is formulated as a once-a-day controlled-release tablet for oral administration designed to deliver 30, 60, or 90 mg of nifedipine. (nih.gov)
  • Client Care Access · Pharmacists & Medical Professionals adalat oros 30 nifedipine gits . (spiritofbaraka.com)
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  • Costco Pharmacy.php on line 3 adalat oros 30 nifedipine gits . (spiritofbaraka.com)
  • In the past, several attempts have been made to develop nifedipine formulations with pharmacokinetic characteristics similar to the unique characteristics of nifedipine GITS. (bioportfolio.com)
  • The functional principle of this nifedipine tablet seems to be quite similar to the one of the GITS system. (bioportfolio.com)
  • To determine whether the combination of nifedipine GITS and valsartan is more effective in reducing central blood pressure than nifedipine GITS or valsartan alone, and to determine whether. (bioportfolio.com)
  • Nifedipine extended release (GITS) is a calcium-channel antagonist known to be metabolically neutral, to mildly slow the development of atherosclerosis in hypertensive subjects and to significantly decrease cardiovascular risk in diabetic patients. (ovid.com)
  • The TALENT study was aimed to determine whether combining low-dose nifedipine GITS at and telmisartan reduced ambulatory and clinic blood pressure more than the two components in monotherapy in hypertensive patients at high cardiovascular risk. (ovid.com)
  • The study shows that combination treatment with nifedipine GITS and telmisartan provides a greater and earlier blood pressure reduction than the combination components in monotherapy. (ovid.com)
  • Nifedipine GITS reduced by a significant 30% the incidence of stroke or TIA in hypertensives and normotensives. (eshonline.org)
  • ACTION compared a long-acting calcium antagonist, nifedipine GITS, to placebo. (eshonline.org)
  • In this patient population, long-acting nifedipine GITS is safe. (eshonline.org)
  • There is a clinically important reduction in stroke, heart failure, hospitalization for angina, revascularization procedures, and importantly coronary artery bypass surgery with nifedipine GITS. (eshonline.org)
  • 3157 patients were analyzed in the long-acting nifedipine group (30 mg/d), and 3164 were in the co-amilozide group (hydrochlorothiazide, 25 mg/d, and amiloride, 2.5 mg/d). (acpjc.org)
  • Sublingual administration of nifedipine promotes a hypotensive effect via peripheral vasodilation. (wikipedia.org)
  • Co-administration of nifedipine with grapefruit juice is to be avoided (See CLINICAL PHARMACOLOGY and PRECAUTIONS ). (rxlist.com)
  • The results are comparable to the Norwegian Nifedipine trial, where administration of nifedipine was not associated with a change in infarct size. (acc.org)
  • Therefore we conducted an experimental study in order to investigate the effect of intravenous administration of nifedipine on the patency of microvascular anastomosis of the femoral artery in rats. (prolekare.cz)
  • To help you remember to take nifedipine, take it at around the same time(s) every day. (medlineplus.gov)
  • Take nifedipine exactly as directed. (medlineplus.gov)
  • Continue to take nifedipine even if you feel well. (medlineplus.gov)
  • Who should not take NIFEDIPINE ER? (webmd.com)
  • Take Nifedipine exactly as directed by your doctor or according to the instructions on the label. (mims.com)
  • Do not take Nifedipine with medicines used to treat TB (infection known as tuberculosis), such as rifampicin. (mims.com)
  • There have been multiple reports in the medical literature of serious adverse effects with sublingual nifedipine, including cerebral ischemia/infarction, myocardial infarction, complete heart block, and death. (wikipedia.org)
  • As a result of this, in 1985 the FDA reviewed all data regarding the safety and effectiveness of sublingual nifedipine for the management of hypertensive emergencies, and concluded that the practice should be abandoned because it was neither safe nor effective. (wikipedia.org)
  • A patient on chronic mao inhibitor's given sublingual nifedipine for hypertensive emergencies (never used in medicine! (healthtap.com)
  • Adalat® CC is an extended release tablet dosage form of the calcium channel blocker nifedipine. (rxlist.com)
  • Nifedipine comes as a capsule and an extended-release (long-acting) tablet to take by mouth. (medlineplus.gov)
  • 1. Nifedipine was administered to eight volunteers (seven Caucasian, one East Asian of Chinese origin) as a single 10 mg capsule orally and as 2.5 mg intravenously. (nih.gov)
  • Nifedipine is available as a tablet or a capsule (in immediate-release form, and extended-release, prolonged-release, sustained-release, or retard form). (mims.com)
  • With the extended-release or other long-acting forms of Nifedipine, you may see a small tablet or capsule-shaped casing in your stool. (mims.com)
  • Nifedipine comes in an immediate release capsule form and is taken 3 or 4 times a day, with or without food. (rxwiki.com)
  • Combination therapy with diltiazem and nifedipine in patients with effort angina pectoris. (ahajournals.org)
  • The antianginal effects of diltiazem and nifedipine alone and in combination were evaluated in a double-blind, randomized, placebo-controlled trial in 11 patients (nine men and two women, 57 +/- 8 years old) with stable effort angina. (ahajournals.org)
  • Each patient received placebo, 30 mg of diltiazem, 10 mg of nifedipine, and 30 mg of diltiazem plus 10 mg of nifedipine four times daily for 1 week each. (ahajournals.org)
  • The exercise tolerance time was significantly prolonged from 235.1 +/- 52 (placebo period) to 342.2 +/- 101 sec by diltiazem (p less than .01) and to 325.6 +/- 73 sec by nifedipine (p less than .01). (ahajournals.org)
  • The drug combination further prolonged exercise time to 451.1 +/- 103 sec, which was significantly longer than the interval attained with either diltiazem (p less than .01) or nifedipine (p less than .01) alone. (ahajournals.org)
  • The plasma concentration of diltiazem was unaffected by the addition of nifedipine, whereas the plasma nifedipine concentration was significantly increased from 34.8 +/- 11 to 106.4 +/- 37 ng/ml (p less than .001) by the concomitant administration of diltiazem. (ahajournals.org)
  • These data suggest that exercise tolerance in patients with effort angina is increased by the concomitant administration of diltiazem and nifedipine associated with an increase in the nifedipine plasma concentration. (ahajournals.org)
  • The objective of this study was to determine release profiles of extemporaneously compounded nifedipine and diltiazem in commonly used bases in pharmacy practice. (ijpc.com)
  • Release of nifedipine 0.2%, 2%, and 10% (w/w) from Glaxal Base, K-Y Jelly, and Aquaphor Healing Ointment, and of diltiazem 2% (w/w) from GlaxalBase, hydroxyethyl cellulose-based gel, and white petrolatum was quantified using the Franz-cell diffusion system. (ijpc.com)
  • Nifedipine and diltiazem release both followed Higuchi's mathematical model with the highest coefficient of determination (R2) for all formulations. (ijpc.com)
  • Thus, cultured endothelial cells were incubated either with nifedipine, diltiazem, or verapamil for 24 h at 10 −5 to 10 −7 M concentrations. (aspetjournals.org)
  • Adalat CC tablets contain either: 30, 60, or 90 mg of nifedipine for once-a-day oral administration. (rxlist.com)
  • Non particular Name: nifedipine (nye FEH dih peen) Brand Names: Adalat What is Adalat CC (nifedipine)? (medicinesmexico.com)
  • Nifedipine oral tablet is available as both a generic drug and brand-name ride. (healthline.com)
  • Nifedipine oral tablet doesn't cause drowsiness. (healthline.com)
  • Nifedipine oral tablet can interact with other medications, vitamins, or herbs you may be taking. (healthline.com)
  • Nifedipine extended-release tablets are similar in appearance to a conventional tablet. (nih.gov)
  • The nifedipine extended-release tablet may contain lactose. (healthbanks.com)
  • Nifedipine: Three 10 mg tablets of Nifedipine followed by one 20 mg tablet every 6 hrs for 48 hrs. (clinicaltrials.gov)
  • A new extended release nifedipine tablet based on an osmotically active system for once a day administration has been registered under the trade name Gen-nifedipine extended release, (previously referred to as Gen-Nifedipine XL (Genpharm ULC, Canada)) in Canada. (bioportfolio.com)
  • Nifedipine is one of the main choices for the treatment of Prinzmetal angina due to its vasodilating effects on the coronary arteries. (wikipedia.org)
  • Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. (fpnotebook.com)
  • Nifedipine is a known material which possesses a coronary dilator activity and is useful for the treatment of so-called angina pectoris attack. (google.com)
  • Nifedipine dilates the main coronary arteries and coronary arterioles, both in normal and ischemic regions, and is a potent inhibitor of coronary artery spasm, whether spontaneous or ergonovine-induced. (nih.gov)
  • This property increases myocardial oxygen delivery in patients with coronary artery spasm, and is responsible for the effectiveness of nifedipine in vasospastic (Prinzmetal's or variant) angina. (nih.gov)
  • You should not use nifedipine if you have severe coronary artery disease, or if you have had a heart attack within the past 2 weeks. (healthbanks.com)
  • Regarding to the underlying mechanism, we examined whether (1) nifedipine changed the mRNA and protein levels of the constitutive endothelial NO synthase (NOS) in endothelial cell cultures or (2) nifedipine exerts an NO protective effect via its antioxidative properties, as revealed in a cell culture model and with native endothelium from porcine coronary arteries. (ahajournals.org)
  • Before taking nifedipine, tell your doctor if you have kidney or liver disease, a blockage in your digestive tract (stomach or intestines), a history of stomach surgery, coronary artery disease, underactive thyroid , diabetes , or congestive heart failure . (emedicinehealth.com)
  • Use of nifedipine may lead to an increased number or severity of heart attacks, particularly in those with coronary artery disease (when blood vessels to the heart become hardened and narrowed). (rxwiki.com)
  • Pregnancy outcomes and successful rate of nifedipine therapeutic protocol implementation in a hospital of San Juan. (curehunter.com)
  • Nifedipine rapidly lowers blood pressure, and patients are commonly warned they may feel dizzy or faint after taking the first few doses. (wikipedia.org)
  • medical citation needed] Extended release formulations of nifedipine should be taken on an empty stomach, and patients are warned not to consume anything containing grapefruit or grapefruit juice, as they raise blood nifedipine levels. (wikipedia.org)
  • By analyzing data from 260 672 insured patients, they were able to document for the first time that doctors continue to prescribe immediate-release nifedipine to elderly patients. (medindia.net)
  • Thus, in 2009, about 1% of the group of elderly patients, who are especially vulnerable to adverse drug reactions, received nifedipine and were therefore exposed to higher risks. (medindia.net)
  • Patients diagnosed with preterm labor who grant consent will be randomized by the pharmacy to receive oral nifedipine or oral indomethacin. (clinicaltrials.gov)
  • The patients will then receive either 25 mg of oral indomethacin every 6 hours for 48 hours, or 20 mg of oral nifedipine every 6 hours for 48 hours. (clinicaltrials.gov)
  • The incidence of adverse events during treatment with nifedipine extended-release tablets in doses up to 90 mg daily were derived from multi-center placebo-controlled clinical trials in 370 hypertensive patients. (rxlist.com)
  • Atenolol 50 mg once daily was used concomitantly in 187 of the 370 patients on nifedipine extended-release tablets and in 64 of the 126 patients on placebo. (rxlist.com)
  • Because patients usually take calcium antagonists for a longer period of time, we investigated whether long-term treatment of endothelial cell cultures with nifedipine may alter the basal endothelial NO release as well as the expression of the constitutive endothelial NO synthase (ecNOS) mRNA and protein. (ahajournals.org)
  • Beta blockers were used prior to enrollment in 13% of patients assigned nifedipine and 21% of patients assigned placebo. (acc.org)
  • Of the 227 patients who were randomly assigned treatment, 112 received nifedipine and 115 placebo. (acc.org)
  • Early treatment with nifedipine in patients with AMI did not appear to reduce infarct size as determined by enzyme level. (acc.org)
  • Those patients having history of cardiac arrythmias, cardiac failure, wheezy chest, and hypersensitivity to either nifedipine or hydralazine were excluded from the study. (thefreelibrary.com)
  • We conclude that in these patients, there was a tendency for mild bronchodilation before exercise with both 150 mg of PY 108-068 and nifedipine, but only the 150-mg dose provided significant protection against exercise-induced asthma two hours after the drug. (biomedsearch.com)
  • Most of the deaths occurred in patients with an in hospital diagnosis of myocardial infarction, and their one month fatality rates were 9.3% for the placebo group and 10.2% for the nifedipine group. (acc.org)
  • Subgroup analysis also did not suggest any particular group of patients with suspected acute myocardial infarction who might benefit from early nifedipine treatment in the dose studied. (acc.org)
  • The use of short-acting nifedipine did not improve mortality when administered to patients with suspected myocardial infarction. (acc.org)
  • 1. In 27 severe primary hypertensive patients nifedipine (10 mg), administered orally, induced prompt (-21% of control at 30 min) and persistent (-17% at 120 min) fall of mean arterial pressure mediated through reduction of peripheral vascular resistance with rise of cardiac output. (clinsci.org)
  • In an open label study, two fixed doses of nifedipine (30 mg and 60 mg daily) were added to the usual antipsychotic drug treatments of 10 patients suffering from chronic schizophrenia. (ovid.com)
  • After the addition of nifedipine, four of the 10 patients showed large increases in plasma neuroleptic activity (radioreceptor assay) that decreased to baseline levels within two weeks. (ovid.com)
  • In the subgroup analysis, new overt heart failure in the hypertensive patients, versus the normotensives, favored nifedipine, with only 47 events versus 76 with placebo. (eshonline.org)
  • The use of Nifedipine therapy in patients with preterm labor between 24-34 weeks of gestational age can be effective in the postponement of labor for 48 hours so that the patient can receive corticosteroid fetal lung maturation therapy. (curehunter.com)
  • Fewer patients, however, tolerated nifedipine. (acpjc.org)
  • The groups did not differ in mean change from baseline in DBP (cilazapril -14.7, atenolol -15.5, nifedipine -14.7 mm Hg), but more patients in the cilazapril group (36%) than in the atenolol group (25%) or the nifedipine group (24%) required HCTZ ( P = 0.01). (acpjc.org)
  • Side effects were the most common reason for withdrawal with nifedipine recipeints having a greater withdrawal rate than atenolol or cilazapril recipients (17%, 8%, and 5% of patients, respectively, P = 0.001). (acpjc.org)
  • Nifedipine tablets are an extended-release form of the drug. (healthline.com)
  • Both the nifedipine immediate-release capsules and extended-release tablets are also available as generic drugs. (healthline.com)
  • Nifedipine extended-release tablets are designed to provide nifedipine at an approximately constant rate over 24 hours. (nih.gov)
  • Nifedipine extended-release tablets depend for its action on the existence of an osmotic gradient between the contents of the bi-layer core and fluid in the gastrointestinal tract. (nih.gov)
  • It is recommended that nifedipine extended-release tablets be administered orally once daily on an empty stomach. (rxlist.com)
  • All adverse events reported during nifedipine extended-release tablets therapy were tabulated independently of their causal relationship to medication. (rxlist.com)
  • The most common adverse event reported with nifedipine extended-release tablets was peripheral edema. (rxlist.com)
  • This was dose related and the frequency was 18% on nifedipine extended-release tablets 30 mg daily, 22% on nifedipine extended-release tablets 60 mg daily and 29% on nifedipine extended-release tablets 90 mg daily versus 10% on placebo. (rxlist.com)
  • Where the frequency of adverse events with nifedipine extended-release tablets and placebo is similar, causal relationship cannot be established. (rxlist.com)
  • The purpose of this study is to measure the amount of study drug present in blood after being administered a generic version of nifedipine extended-release tablets, 60 mg (Valeant Pharmace. (bioportfolio.com)
  • The extended release form of nifedipine, is a prescription medication used to treat chest pain and high blood pressure. (rxwiki.com)
  • In the US, Nifedipine (nifedipine systemic) is a member of the drug class calcium channel blocking agents and is used to treat Angina Pectoris Prophylaxis , Heart Failure , High Blood Pressure , Hypertensive Emergency , Hypertrophic Cardiomyopathy , Migraine Prevention , Premature Labor and Raynaud's Syndrome . (drugs.com)
  • Nifedipine is a drug belonging to a class of pharmacological agents known as the calcium channel blockers. (nih.gov)
  • Researchers have issued a warning that doctors still continue to prescribe the blood pressure drug, nifedipine, despite the fact that the drug increases the risk of heart attacks and death. (medindia.net)
  • Immediate-release nifedipine is classified as a potentially dangerous drug in the PRISCUS list published in 2010. (medindia.net)
  • Recently, increasing evidence suggests that the antihypertensive drug nifedipine acts as a protective agent for endothelial cells, and that the activity is unrelated to its calcium channel blocking. (nii.ac.jp)
  • This study will compare the efficacy and adverse outcomes of oral nifedipine versus oral indomethacin for preterm labor tocolysis in an effort to identify which drug is most effective. (clinicaltrials.gov)
  • Few adverse drug reactions occurred and nifedipine was well-tolerated in both populations. (dovepress.com)
  • This is not a complete list of nifedipine drug interactions. (rxwiki.com)
  • Click Nifedipine Warnings and Precautions to learn more, including information on who should not take the drug. (emedtv.com)
  • Drug release from nifedipine microspheres was studied in a medium, which simulated the change in pH of the pathway of the microspheres from stomach to intestine. (sid.ir)
  • Nifedipine is a drug of calcium-channel blocking group. (prolekare.cz)
  • Cilazapril, atenolol, and nifedipine were equally effective in controlling blood pressure but nifedipine was associated with more frequent adverse-effect-related drug discontinuation than was atenolol or cilazapril. (acpjc.org)
  • Nifedipine is in a class of medications called calcium-channel blockers. (medlineplus.gov)
  • Nifedipine, sold under the brand name Adalat among others, is a calcium channel blocker medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor. (wikipedia.org)
  • As calcium channel blocker, nifedipine has a risk of causing gingival hyperplasia A number of persons have developed toxicity due to acute overdosage with nifedipine, either accidentally or intentionally, and via either oral or parenteral administration. (wikipedia.org)
  • 6,7) Long-acting nitrates such as isosorbide, calcium channel blockers such as nifedipine , and phosphodiesterase-5 (PDE5) inhibitors such as sildenafil reduce lower esophageal sphincter tone and pressure. (thefreedictionary.com)
  • Nifedipine is the only calcium channel blocker that has resulted in improved outcomes. (thefreedictionary.com)
  • Nifedipine belongs to a class of drugs called calcium channel blockers. (healthline.com)
  • Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. (drugbank.ca)
  • Nifedipine, the prototype of the dihydropyridine class of calcium channel blockers (CCBs), is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. (drugbank.ca)
  • Nifedipine is in a group of drugs called calcium channel blockers. (healthbanks.com)
  • Currently, nifedipine, which directly blocks the calcium channel, would be in fact the first choice tocolytic agent to postpone delivery [ 2 , 19 ]. (hindawi.com)
  • Nifedipine belongs to the class of calcium channel antagonist drugs and finds a wide use as an antihypertensive and an antianginal agent. (sigmaaldrich.com)
  • In the APOSTEL III trial we aimed to compare the effectiveness and safety of the calcium-channel blocker nifedipine and the oxytocin inhibitor atosiban in women with threatened preterm birth. (unboundmedicine.com)
  • The calcium channel blocker nifedipine was administered to pregnant sheep by a four-level iv infusion at rates of 1-10 micrograms/kg/min. (aspetjournals.org)
  • Adalat (Nifedipine) is a calcium channel blocker used to treat high blood pressure. (medformula.com)
  • Adalat (nifedipine) is a calcium channel blocker. (medformula.com)
  • age 0-18 years) one practice guideline (1), six case reports or patient series of PHHI treated with nifedipine (7-12), one report on the safety of calcium channel blockers in children (2). (bestbets.org)
  • This is a brand name for Nifedipine which is a calcium channel blocker. (healthtap.com)
  • However, nifedipine (both short- and long-term treatment) significantly reduced the basal and glucose (20 and 30 mmol/L)-stimulated formation of reactive oxygen species (lucigenin assay) of endothelial cell cultures and native cells. (ahajournals.org)
  • We conclude that the calcium antagonist nifedipine enhances the bioavailability of endothelial NO without significantly altering the NOS (type III) mRNA and protein expression, possibly via an antioxidative protection. (ahajournals.org)
  • We demonstrated for the first time that nifedipine significantly enhanced iron content as well as TfR1 and DMT1 expression and had no effect on Fpn1 levels in the cells. (frontiersin.org)
  • 3. Plasma renin activity rose slightly in nifedipine treated SB and SBN rats, but decreased significantly in treated SBH rats. (portlandpress.com)
  • In the main study, a blood pressure below 140/90 mm Hg significantly favored nifedipine versus placebo for the primary endpoint (p=0.02). (eshonline.org)
  • Nifedipine is used to treat high blood pressure and to control angina (chest pain). (medlineplus.gov)
  • If taken regularly, nifedipine controls chest pain, but it does not stop chest pain once it starts. (medlineplus.gov)
  • Nifedipine controls high blood pressure and chest pain (angina) but does not cure them. (medlineplus.gov)
  • If you get any chest pain after taking a dose of nifedipine you should not take a further dose until you have consulted your doctor. (netdoctor.co.uk)
  • Nifedipine treat high blood pressure and controls chest pain. (rxwiki.com)
  • Nifedipine is a prescription medication used to treat chest pain. (rxwiki.com)
  • Do not stop taking nifedipine without talking to your doctor. (medlineplus.gov)
  • Do not stop taking nifedipine without first talking to your doctor, even if you feel fine. (emedicinehealth.com)
  • Your doctor will probably start you on a low dose of nifedipine and gradually increase your dose, generally once every 7 to 14 days. (medlineplus.gov)
  • Our data indicate that nifedipine blocks the determined path of pluripotent stem cells to cardiomyogenesis by inhibition of mesodermal commitment at early stages of differentiation, thus the proper upkeep Ca(2+) concentration and pathways are essentially required for cardiac gene expression, differentiation and function. (nih.gov)
  • The composition of this invention can increase the bioavailability of nifedipine and makes it possible to provide a nifedipine-containing pharmaceutical preparation which has small bulk and can be easily administered. (google.com)
  • Hemodynamic and humoral interactions between captopril and nifedipine. (ahajournals.org)
  • Nifedipine regularly reduces arterial pressure at rest and at a given level of exercise by dilating peripheral arterioles and reducing the total peripheral vascular resistance (afterload) against which the heart works. (nih.gov)
  • In anesthetized rats subjected to LPS, pretreatment with nifedipine or dexamethasone ameliorated the fall in mean arterial blood pressure and the vascular hyporeactivity to norepinephrine at 180 min after LPS injection. (aspetjournals.org)
  • SAN DIEGO -- Nifedipine and atosiban for tocolysis in women with threatened preterm delivery had similar rates of adverse perinatal outcomes in a randomized clinical trial, but an increase in perinatal mortality in those treated with nifedipine is raising concerns about its safety. (thefreedictionary.com)
  • In women with threatened preterm birth, 48 h of tocolysis with nifedipine or atosiban results in similar perinatal outcomes. (unboundmedicine.com)
  • To investigate whether early intervention with nifedipine in acute myocardial infarction might reduce infarct size, as determined by creatine kinase MB isoenzymes. (acc.org)
  • In a similar fashion, the Trent nifedipine study observed no mortality benefit from nifedipine after myocardial infarction. (acc.org)
  • Earlier studies demonstrated that, in comparison to other antihypertensive drugs, nifedipine increases patient risk for mortality and heart attacks. (medindia.net)
  • NO-NIF has no antihypertensive effect, and it has been recognized as a contaminant of nifedipine. (nii.ac.jp)
  • Quality of life with three antihypertensive treatments: cilazapril, atenolol, nifedipine. (acpjc.org)
  • Grapefruit juice can increase the amount of nifedipine in your blood and so increase the risk of you getting side effects. (netdoctor.co.uk)
  • What side effects should I look out for while taking nifedipine? (netdoctor.co.uk)
  • What side effects can Adalat (Nifedipine) cause? (medformula.com)
  • Serious side effects have been reported with nifedipine. (rxwiki.com)
  • This is not a complete list of nifedipine side effects. (rxwiki.com)
  • Other than documenting more side effects with nifedipine, how do results such as these help us? (acpjc.org)
  • Avoid drinking grapefruit juice or eating a lot of grapefruit while you are taking nifedipine. (netdoctor.co.uk)
  • Do not drink grapefruit juice or eat grapefruit 3 days before and while taking nifedipine. (rxwiki.com)
  • Nifedipine given as sublingual administration has previously been used in hypertensive emergencies. (wikipedia.org)
  • Objective: To compare oral nifedipine with intravenous hydralazine in their rapidity to control hypertensive emergencies of pregnancy. (thefreelibrary.com)
  • Data obtained from 42 women, of which 19 were randomized to the ritodrine group and 23 to the nifedipine group, were analyzed. (biomedsearch.com)
  • Infarct size index (CK-MB geq/m 2 ) was 25 +/- 16 (n = 71) in the nifedipine group and 23 +/- 13 (n = 77) in the placebo group (NS). (acc.org)
  • 0.05) following oral nifedipine. (nih.gov)
  • Though both 150 mg of PY 108-068 and nifedipine were associated with mild bronchodilation before exercise, only the latter was significant (p less than 0.05). (biomedsearch.com)
  • The nifedipine group had a greater increase in complaints score (most commonly edema, flushing, and headache) than the atenolol group ( P = 0.02) or the cilazapril group ( P = 0.05). (acpjc.org)
  • Objective: To find out the effectiveness of oral nifedipine as a tocolytic agent in external cephalic version. (thefreedictionary.com)
  • Nifedipine is also available in immediate-release oral capsules. (healthline.com)
  • Following randomization, the patient will be given either 50 mg oral indomethacin with two pills of placebo, or 3 pills each containing 10 mg oral nifedipine for a total of 30 mg. (clinicaltrials.gov)
  • Afeditab® CR tablets contain either 30 mg or 60 mg of nifedipine for once-a-day oral administration. (rxlist.com)
  • The purpose of our research was to compare I/V hydralazine with oral nifedipine in regard to efficacy and safety in controlling the blood pressure. (thefreelibrary.com)
  • Women with threatened preterm birth (gestational age 25-34 weeks) were randomly assigned (1:1) to either oral nifedipine or intravenous atosiban for 48 h. (unboundmedicine.com)
  • it does conclude that most included studies used low doses of nifedipine. (wikipedia.org)
  • In 12 asthmatic adults with relatively severe exercise-induced asthma, we compared the effect of a new calcium antagonist, PY 108-068, in doses of 75 mg and 150 mg with nifedipine (30 mg) and placebo on resting flow rates and flow rates after exercise. (biomedsearch.com)
  • Generic Adalat (Nifedipine) is a medication made to regulate high blood pressure. (oostrov.ru)
  • The maternal and fetal plasma nifedipine concentrations were measured along with maternal and fetal heart rate, blood pressure, pH, and blood gases. (aspetjournals.org)
  • Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. (nih.gov)
  • Nifedipine is practically insoluble in water and soluble in alcohol. (uspharmacist.com)
  • Nifedipine is taken by mouth and comes in fast- and slow-release formulations. (wikipedia.org)
  • Nifedipine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by spectrophotometry and chromatography techniques. (sigmaaldrich.com)
  • The cumulative drop-out rate was higher for the nifedipine group (21%) than for the atenolol group (13%) or the cilazapril group (14%) ( P = 0.04). (acpjc.org)
  • Nifedipine was administered intravenous (2 mg/kg) to ensure the same dose for all the animals. (prolekare.cz)
  • Anticonvulsants barbiturates benzodiazepines drugs this can be as simple as eating a the peanuts will provide conceptualized on the ideology can be nifedipine er 30 mg tablets into glands in check). (libero.it)
  • Many drugs can interact with nifedipine. (emedicinehealth.com)
  • Fatigue score was improved (less fatigue) on nifedipine compared with the 2 other drugs ( P = 0.04). (acpjc.org)
  • Nifedipine 10mg sublingually, then 10mg po qid for 6 weeks, or placebo. (acc.org)
  • Headache, which occurred in six subjects after nifedipine, five after 150 mg of PY 108-068, one after 75 mg of PY 108-068, and none after placebo, was subjectively more severe after nifedipine. (biomedsearch.com)
  • Nifedipine vs. placebo for mortality in acute MI. (acc.org)
  • Nifedipine, 10mg four times daily, vs placebo. (acc.org)
  • The overall one month mortality rates were 6.3% in the placebo treated group and 6.7% in the nifedipine treated group. (acc.org)
  • A randomized prospective study was performed to compare the efficacy of nifedipine to ritodrine in the suppression of preterm labor. (biomedsearch.com)
  • tell your doctor and pharmacist if you are allergic to nifedipine, any other medications, or any of the ingredients in nifedipine. (medlineplus.gov)
  • Indomethacin and Nifedipine are commonly used medications for treatment of pre term labor. (clinicaltrials.gov)
  • Nifedipine is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle. (nih.gov)
  • Nifedipine selectively inhibits calcium ion influx across the cell membrane of cardiac muscle and vascular smooth muscle without altering serum calcium concentrations. (nih.gov)
  • Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide. (aspetjournals.org)
  • Thus, nifedipine inhibits the induction of NOS in response to LPS in cultured cells in vitro and in the anesthetized rat. (aspetjournals.org)
  • A study in animals (2) has suggested that nifedipine decreases the pulmonary pressor response to hypoxia. (annals.org)
  • Nifedipine loosens up (widens) your (veins and supply courses), which makes it less requesting for the heart to pump and decreases its workload. (medicinesmexico.com)
  • In addition, nifedipine decreases platelet aggregation and reduces the extent of cell injury of marginally viable cells by blocking the influx of intracellular calcium (10). (prolekare.cz)