The most well known avian paramyxovirus in the genus AVULAVIRUS and the cause of a highly infectious pneumoencephalitis in fowl. It is also reported to cause CONJUNCTIVITIS in humans. Transmission is by droplet inhalation or ingestion of contaminated water or food.
An acute febrile, contagious, viral disease of birds caused by an AVULAVIRUS called NEWCASTLE DISEASE VIRUS. It is characterized by respiratory and nervous symptoms in fowl and is transmissible to man causing a severe, but transient conjunctivitis.
Glycoprotein from Sendai, para-influenza, Newcastle Disease, and other viruses that participates in binding the virus to cell-surface receptors. The HN protein possesses both hemagglutinin and neuraminidase activity.
Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.
The type species of APHTHOVIRUS, causing FOOT-AND-MOUTH DISEASE in cloven-hoofed animals. Several different serotypes exist.
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
A species in the genus Bornavirus, family BORNAVIRIDAE, causing a rare and usually fatal encephalitic disease in horses and other domestic animals and possibly deer. Its name derives from the city in Saxony where the condition was first described in 1894, but the disease occurs in Europe, N. Africa, and the Near East.
Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
A species of AVIBIRNAVIRUS causing severe inflammation of the bursa of Fabricius in chickens and other fowl. Transmission is thought to be through contaminated feed or water. Vaccines have been used with varying degrees of success.
A phenomenon manifested by an agent or substance adhering to or being adsorbed on the surface of a red blood cell, as tuberculin can be adsorbed on red blood cells under certain conditions. (Stedman, 25th ed)
Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.
A genus of the family PICORNAVIRIDAE infecting mainly cloven-hoofed animals. They cause vesicular lesions and upper respiratory tract infections. FOOT AND MOUTH DISEASE VIRUS is the type species.
Process of growing viruses in live animals, plants, or cultured cells.
An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
Agglutination of ERYTHROCYTES by a virus.
Proteins found in any species of virus.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
A family of spherical viruses, of the order MONONEGAVIRALES, somewhat larger than the orthomyxoviruses, and containing single-stranded RNA. Subfamilies include PARAMYXOVIRINAE and PNEUMOVIRINAE.
Specific hemagglutinin subtypes encoded by VIRUSES.
A dilated cavity extended caudally from the hindgut. In adult birds, reptiles, amphibians, and many fishes but few mammals, cloaca is a common chamber into which the digestive, urinary and reproductive tracts discharge their contents. In most mammals, cloaca gives rise to LARGE INTESTINE; URINARY BLADDER; and GENITALIA.
Ribonucleic acid that makes up the genetic material of viruses.
An order of flightless birds comprising the ostriches, which naturally inhabit open, low rainfall areas of Africa.
A species of RESPIROVIRUS also called hemadsorption virus 2 (HA2), which causes laryngotracheitis in humans, especially children.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.
A species in the genus LAGOVIRUS which causes hemorrhagic disease, including hemorrhagic septicemia, in rabbits.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Viruses whose genetic material is RNA.
Established cell cultures that have the potential to propagate indefinitely.
Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons.
Serological tests that measure anti-hemadsorption agents such as antiviral ANTIBODIES that block VIRAL HEMAGGLUNININS from adhering to the surface of red blood cells.
A genus in the subfamily PARAMYXOVIRINAE, family PARAMYXOVIRIDAE, causing disease in domestic fowl. There are many species, the most well-known being avian paramyxovirus 1 (NEWCASTLE DISEASE VIRUS).
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
The use of techniques that produce a functional MUTATION or an effect on GENE EXPRESSION of a specific gene of interest in order to identify the role or activity of the gene product of that gene.
The type species of VESICULOVIRUS causing a disease symptomatically similar to FOOT-AND-MOUTH DISEASE in cattle, horses, and pigs. It may be transmitted to other species including humans, where it causes influenza-like symptoms.
An encephalomyelitis of horses, sheep and cattle caused by BORNA DISEASE VIRUS.
A cultured line of C3H mouse FIBROBLASTS that do not adhere to one another and do not express CADHERINS.
Diseases of birds not considered poultry, therefore usually found in zoos, parks, and the wild. The concept is differentiated from POULTRY DISEASES which is for birds raised as a source of meat or eggs for human consumption, and usually found in barnyards, hatcheries, etc.
Methods of maintaining or growing biological materials in controlled laboratory conditions. These include the cultures of CELLS; TISSUES; organs; or embryo in vitro. Both animal and plant tissues may be cultured by a variety of methods. Cultures may derive from normal or abnormal tissues, and consist of a single cell type or mixed cell types.
A transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. There is lymphoid cell infiltration or lymphomatous tumor formation in the peripheral nerves and gonads, but may also involve visceral organs, skin, muscle, and the eye.
Infections with viruses of the genus AVULAVIRUS, family PARAMYXOVIRIDAE. This includes NEWCASTLE DISEASE and other infections of domestic fowl.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract, and intestinal tract. Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
Warm-blooded VERTEBRATES possessing FEATHERS and belonging to the class Aves.
The relationships of groups of organisms as reflected by their genetic makeup.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
Substances elaborated by viruses that have antigenic activity.
Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)
Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.
The type species of RUBULAVIRUS that causes an acute infectious disease in humans, affecting mainly children. Transmission occurs by droplet infection.
A genus of the family PARAMYXOVIRIDAE (subfamily PARAMYXOVIRINAE) where all the virions have both HEMAGGLUTININ and NEURAMINIDASE activities and encode a non-structural C protein. SENDAI VIRUS is the type species.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A species of PESTIVIRUS causing a congenital sheep disease characterized by an abnormally hairy birth-coat, tremors, and poor growth.
Virus diseases caused by the BIRNAVIRIDAE.
The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.
A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 1. The H5N1 subtype, frequently referred to as the bird flu virus, is endemic in wild birds and very contagious among both domestic (POULTRY) and wild birds. It does not usually infect humans, but some cases have been reported.
The functional hereditary units of VIRUSES.
Use of attenuated VIRUSES as ANTINEOPLASTIC AGENTS to selectively kill CANCER cells.
The type species of the genus AVIPOXVIRUS. It is the etiologic agent of FOWLPOX.
A subfamily of PARAMYXOVIRIDAE. Genera include RUBULAVIRUS; RESPIROVIRUS; MORBILLIVIRUS; HENIPAVIRUS; and AVULAVIRUS.
The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
A species of PARVOVIRUS that causes a disease in mink, mainly those homozygous for the recessive Aleutian gene which determines a desirable coat color.
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
A genus in the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, associated with malignancy in birds.
Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
A family of RNA viruses causing INFLUENZA and other diseases. There are five recognized genera: INFLUENZAVIRUS A; INFLUENZAVIRUS B; INFLUENZAVIRUS C; ISAVIRUS; and THOGOTOVIRUS.
Interferon inducer consisting of a synthetic, mismatched double-stranded RNA. The polymer is made of one strand each of polyinosinic acid and polycytidylic acid.
An order of large, long-necked, long-legged, flightless birds, found in South America. Known as rheas, they are sometimes called American ostriches, though they are in a separate order from true OSTRICHES.
Infection of domestic and wild fowl and other BIRDS with INFLUENZA A VIRUS. Avian influenza usually does not sicken birds, but can be highly pathogenic and fatal in domestic POULTRY.
Viruses whose taxonomic relationships have not been established.
Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).
The type species of MORBILLIVIRUS and the cause of the highly infectious human disease MEASLES, which affects mostly children.
A phenomenon in which infection by a first virus results in resistance of cells or tissues to infection by a second, unrelated virus.
A poxvirus infection of poultry and other birds characterized by the formation of wart-like nodules on the skin and diphtheritic necrotic masses (cankers) in the upper digestive and respiratory tracts.
A republic in western Africa, lying between GHANA on its west and BENIN on its east. Its capital is Lome.
A species of ORBIVIRUS causing a fatal disease in deer. It is transmitted by flies of the genus Culicoides.
Animals or humans raised in the absence of a particular disease-causing virus or other microorganism. Less frequently plants are cultivated pathogen-free.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A general term for diseases produced by viruses.
Proteins conjugated with nucleic acids.
A species of RESPIROVIRUS frequently isolated from small children with pharyngitis, bronchitis, and pneumonia.
Large woodland game BIRDS in the subfamily Meleagridinae, family Phasianidae, order GALLIFORMES. Formerly they were considered a distinct family, Melegrididae.
Family in the order COLUMBIFORMES, comprised of pigeons or doves. They are BIRDS with short legs, stout bodies, small heads, and slender bills. Some sources call the smaller species doves and the larger pigeons, but the names are interchangeable.
A species of CORONAVIRUS causing infections in chickens and possibly pheasants. Chicks up to four weeks old are the most severely affected.
Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.
A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 2. The H5N2 subtype has been found to be highly pathogenic in chickens.
Deoxyribonucleic acid that makes up the genetic material of viruses.
The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.
The type species of RESPIROVIRUS in the subfamily PARAMYXOVIRINAE. It is the murine version of HUMAN PARAINFLUENZA VIRUS 1, distinguished by host range.
The degree of similarity between sequences. Studies of AMINO ACID SEQUENCE HOMOLOGY and NUCLEIC ACID SEQUENCE HOMOLOGY provide useful information about the genetic relatedness of genes, gene products, and species.

Amino acid substitutions in a conserved region in the stalk of the Newcastle disease virus HN glycoprotein spike impair its neuraminidase activity in the globular domain. (1/926)

The ectodomain of the paramyxovirus haemagglutinin-neuraminidase (HN) glycoprotein spike can be divided into two regions: a membrane-proximal, stalk-like structure and a terminal globular domain. The latter contains all the antibody recognition sites of the protein, as well as its receptor recognition and neuraminidase (NA) active sites. These two activities of the protein can be separated by monoclonal antibody functional inhibition studies and mutations in the globular domain. Herein, we show that mutation of several conserved residues in the stalk of the Newcastle disease virus HN protein markedly decrease its NA activity without a significant effect on receptor recognition. Thus, mutations in the stalk, distant from the NA active site in the globular domain, can also separate attachment and NA. These results add to an increasing body of evidence that the NA activity of this protein is dependent on an intact stalk structure.  (+info)

Pathogenesis of Newcastle disease in chickens experimentally infected with viruses of different virulence. (2/926)

Groups of 4-week-old White Rock chickens were inoculated intraconjunctivally with nine isolates of Newcastle disease virus representing all pathotypes. Birds were monitored clinically and euthanatized sequentially, with collection of tissues for histopathologic examination and in situ hybridization using an anti-sense digoxigenin-labeled riboprobe corresponding to the sequence of the gene coding for the matrix protein. Disease was most severe with velogenic viscerotropic pathotypes and was characterized by acute systemic illness with extensive necrosis of lymphoid areas in the spleen and intestine. Viral nucleic acid was detected in multiple tissues but most prominently in macrophages associated with lymphoid tissue. Velogenic neurotropic isolates caused central nervous system disease despite minimal amounts of viral nucleic acid detected in neural tissue. Mesogenic and lentogenic pathotypes caused no overt disease; however, viral nucleic acid was present in myocardium and air sac epithelium following infection with these isolates. Compromise of air sac and myocardium may predispose mesogen- and lentogen-infected chickens to secondary infection and/or decreased meat and egg production.  (+info)

Isolation and characterization of monoclonal antibodies directed against murine FRP-1/CD98/4F2 heavy chain: murine FRP-1 is an alloantigen and amino acid change at 129 (P<-->R) is related to the alloantigenicity. (3/926)

Nineteen mAb directed against murine fusion regulatory protein-1 (mFRP-1)/4F2/CD98 were isolated and their biological properties were analysed. Intriguingly, mFRP-1 was found to be an alloantigen, namely, FRP-1.1 (DBA/2 and CBA mice type) and FRP-1.2 (BALB/c, C57BL/6 and C3H/He mice type). The nucleotide sequences of FRP-1.1 and FRP-1.2 were determined, demonstrating that amino acid change at 129 (P<-->R) is related to the alloantigenicity. mFRP-1 is expressed on thymocytes, on spleen cells, on peripheral lymphocytes and on blood monocytes, suggesting that the physiological role in vivo of murine FRP-1 is different from that of human FRP-1. The biological activities of antimFRP-1 mAbs showed by the present study are: (i) enhancement of Newcastle disease virus-induced cell fusion; (ii) suppression of HIVgp160-mediated cell fusion; and (iii) induction of aggregation and multinucleated giant cells of monocytes/macrophages.  (+info)

Mutational analysis of heptad repeats in the membrane-proximal region of Newcastle disease virus HN protein. (4/926)

For most paramyxoviruses, syncytium formation requires the expression of both surface glycoproteins (HN and F) in the same cell, and evidence suggests that fusion involves a specific interaction between the HN and F proteins (X. Hu et al., J. Virol. 66:1528-1534, 1992). The stalk region of the Newcastle disease virus (NDV) HN protein has been implicated in both fusion promotion and virus specificity of that activity. The NDV F protein contains two heptad repeat motifs which have been shown by site-directed mutagenesis to be critical for fusion (R. Buckland et al., J. Gen. Virol. 73:1703-1707, 1992; T. Sergel-Germano et al., J. Virol. 68:7654-7658, 1994; J. Reitter et al., J. Virol. 69:5995-6004, 1995). Heptad repeat motifs mediate protein-protein interactions by enabling the formation of coiled coils. Upon analysis of the stalk region of the NDV HN protein, we identified two heptad repeats. Secondary structure analysis of these repeats suggested the potential for these regions to form alpha helices. To investigate the importance of this sequence motif for fusion promotion, we mutated the hydrophobic a-position amino acids of each heptad repeat to alanine or methionine. In addition, hydrophobic amino acids in other positions were also changed to alanine. Every mutant protein retained levels of attachment activity that was greater than or equal to the wild-type protein activity and bound to conformation-specific monoclonal as well as polyclonal antisera. Neuraminidase activity was variably affected. Every mutation, however, showed a dramatic decrease in fusion promotion activity. The phenotypes of these mutant proteins indicate that individual amino acids within the heptad repeat region of the stalk domain of the HN protein are important for the fusion promotion activity of the protein. These data are consistent with the idea that the HN protein associates with the F protein via specific interactions between the heptad repeat regions of both proteins.  (+info)

Rescue of Newcastle disease virus from cloned cDNA: evidence that cleavability of the fusion protein is a major determinant for virulence. (5/926)

A full-length cDNA clone of Newcastle disease virus (NDV) vaccine strain LaSota was assembled from subgenomic overlapping cDNA fragments and cloned in a transcription plasmid between the T7 RNA polymerase promoter and the autocatalytic hepatitis delta virus ribozyme. Transfection of this plasmid into cells that were infected with a recombinant fowlpoxvirus that expressed T7 RNA polymerase, resulted in the synthesis of antigenomic NDV RNA. This RNA was replicated and transcribed by the viral NP, P, and L proteins, which were expressed from cotransfected plasmids. After inoculation of the transfection supernatant into embryonated specific-pathogen-free eggs, infectious virus derived from the cloned cDNA was recovered. By introducing three nucleotide changes in the cDNA, we generated a genetically tagged derivative of the LaSota strain in which the amino acid sequence of the protease cleavage site (GGRQGR downward arrowL) of the fusion protein F0 was changed to the consensus cleavage site of virulent NDV strains (GRRQRR downward arrowF). Pathogenicity tests in day-old chickens showed that the strain derived from the unmodified cDNA was completely nonvirulent (intracerebral pathogenicity index [ICPI] = 0.00). However, the strain derived from the cDNA in which the protease cleavage site was modified showed a dramatic increase in virulence (ICPI = 1.28 out of a possible maximum of 2.0). Pulse-chase labeling of cells infected with the different strains followed by radioimmunoprecipitation of the F protein showed that the efficiency of cleavage of the F0 protein was greatly enhanced by the amino acid replacements. These results demonstrate that genetically modified NDV can be recovered from cloned cDNA and confirm the supposition that cleavage of the F0 protein is a key determinant in virulence of NDV.  (+info)

Local immunity in the respiratory tract of the chicken. I. Transudation of circulating antibody in normal and virus-infected birds. (6/926)

Three-week-old chickens were given sheep erythrocytes or bovine serum albumin intravenously. Seven days later their tears and saliva possessed low levels of antibody to those antigens. Concurrent infection with lentogenic Newcastle disease virus (NDV) caused a significant increase in transuded antibody in those fluids. In chickens with circulating antibody to NDV, induced by parenterally administered inactivated vaccine, respiratory infection with heterologous infectious bronchitis virus resulted in limited transudation of anti-NDV. In contrast, the tears, saliva and tracheal fluid of non-vaccinated chickens undergoing primary infection with NDV acquired considerable levels of specific anti-NDV. The difference between the two groups is attributed to locally synthesized antibody.  (+info)

Purification of two components of mouse L cell interferon: electrophoretic demonstration of interferon proteins. (7/926)

Mouse L cell interferon induced by Newcastle disease virus was purified by the procedure described previously (Yamamoto et al. 1974) followed by gel filtration. The two fractions obtained containing interferon species S (36000 daltons) and F (24000 daltons), respectively, were analysed electrophoretically at pH 4-3, or in the presence of sodium dodecyl sulphate (SDS) at pH 7-2. In both fractions, interferon activity was invariably associated with distinct protein bands. In the F-containing fraction there were essentially no other proteins, and in the S-containing fraction, impurity proteins were well separated from the interferon activity. The apparent mol. wt. determined by SDS-gel electrophoresis showed little or no dependence on gel concentration, suggesting that the interferons had low carbohydrate contents, and did not change after reduction with thiol reagents in SDS and urea.  (+info)

The production and action of interferon in Chinese hamster cells. (8/926)

The interferon system has been investigated in primary cell cultures established from Chinese hamster embryos and new born pups. Interferon synthesis was induced with Sindbis virus, ultraviolet inrradiated Newcastle disease virus (u.v.-NDV) and with polyriboinosine acid-polyribocytidylic acid complex [poly (rI). poly (rC)]. Only u.v.-NDV induced significant production of interferon, maximum amounts being produced in 'aged' cells. Its apparent mol. wt. was 25000. CHO-KI cells, an established line of Chinese hamster cells, did not synthesize interferon in response to viruses, but were sensitive to its action.  (+info)

Newcastle disease virus (NDV) is a naturally oncolytic virus that has been shown to be safe and effective for cancer therapy. Tumor virotherapy using NDV emerged in the 1950s and has advanced more recently by the increased availability of reverse genetics technology. In this study, we constructed a reverse genetics system based on the virulent and oncolytic NDV Italien strain, and generated two recombinant NDVs carrying a gene encoding either enhanced green fluorescent protein or firefly luciferase. We evaluated the replication and antitumor characteristics of these viruses in vitro and in vivo. Our data showed that the insertion of exogenous reporter genes did not affect NDV replication and sensitivity to type I interferon. The recombinant NDVs kept the property of tumor-selective replication both in vitro and in vivo and strongly induced syncytium formation leading to cell death. Moreover, the recombinant NDVs significantly prolonged the survival of tumor-bearing athymic mice (p=0.017) and ...
Newcastle disease (ND) is regarded as a highly contagious and economically important disease in poultry and has a worldwide distribution. Viral determinants for Newcastle disease virus (NDV) virulence are not completely understood and viruses of different pathotypes can be found at live-bird markets in different geographical areas. The prevalence of Newcastle disease in village poultry in Mozambique is not well documented and strains of NDV involved in yearly outbreaks are unknown. The fusion (F) protein is an important determinant of pathogenicity of the virus and is used commonly for phylogenetic analysis. Newcastle disease viruses from various geographical regions of Mozambique were sequenced and compared genetically to published sequences obtained from GenBank. Samples were collected in three different areas of Mozambique and NDV was isolated by infection of embryonated chicken eggs. Sequence analysis of the F-protein encoding gene was used to classify 28 isolates from Mozambique into ...
The appearance of very aggressive outbreaks of Newcastle disease is caused by velogenic strains with genotypes different from those present in the classic vaccines currently being used, resulting in doubts about the efficacy of classical live attenuated vaccines. Newcastle disease (ND) is caused by virulent forms of avian Paramyxovirus serotype 1 (APMV-1). Newcastle Disease virus (NDV) is classified into different classes and genotypes based on its genetic characteristics. Epidemiological control of Newcastle disease in broilers is possible (amongst other tools) thanks to the intensive use of prophylactic vaccination. In general, the most common vaccines in the world against this disease are based on two main genotypes of live lentogenic NDV (genotype I and II), characterised by low pathogenicity or apathogenicity. The genetic divergence between the genotypes of the vaccines and the circulating viruses raises questions about their efficacy.. An independent study by Jeon et al. demonstrated the ...
Nutritional Enhancement of Soybean - Wendy Peer. The Peer Lab - Wendy Peer. Composting effective at reducing estrogens in broiler litter - Lance Yonkos and Gary Felton. Turning Poultry Litter to Energy with Enhanced Nutrient Recovery: Overview of Anaerobic Digestion, Gasification and Fluidized Bed Combustion Projects - Stephanie Lansing, Gary Felton, Freddy Witarsa, Amro Hassanein, Rohan Tikekar and Jonathan Moyle. Optimizing phosphorus digestibility through calcium management. The importance of digestible calcium - Roselina Angel. Metabolic and hormonal effects of heat stress in broiler chickens - Tom Porter. The importance of UV light for broiler well-being - Rachel Lynn Dennis. A recombinant Newcastle disease virus (NDV) expressing S gene of infectious bronchitis virus (IBV) protects chickens against virulent IBV and NDV challenges - Edris Shirvani, Anandan Paldurai, Vinoth Manoharan, Berin Parambethu Varghese and Siba K. Samal. A recombinant Newcastle disease virus (NDV) expressing gD gene ...
Newcastle disease virus infection in 38 weeks old layer brown chicken, mild respiratory signs, normal daily mortality rate, drop of egg production, change color egg, abnormal shape. Velogenic Newcastle disease virus is the deadliest virus for poultry. So many people assume, if this virus infects a chicken flock, then they […]. ...
Read Existence of two forms of L protein of Newcastle disease virus isolates due to a compensatory mutation in Domain V, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Pullets about to enter a laying flock were revaccinated by intramuscular injection of live Mukteswar strain Newcastle disease virus, a procedure commonly used in Pakistan. Chicks hatched from eggs produced 24 weeks later were assessed for passively acquired immunity. Levels of haemagglutination-inhibition (HI) antibody and resistance to challenge with velogenic Newcastle disease virus were determined on groups of 50 chicks at 1, 4, 7, 10, 13, 16, 19, 22 and 25 days of age. Levels of maternally derived antibody declined from a geometric mean titre of 40 (25.3) on the day of hatching to less than two (20.3) at 25 days of age, with a decline of 1log2 in about 5 days. Mortalities after challenge varied from 18% at 1 day of age to 90% at 25 days of age. Survival was significantly related to the level of antibody at the time of challenge. None of 111 chickens with an antibody titre of 40 (25.3) or more succumbed to challenge. Mortality rates varied from 78.6% in chicks with no detectable antibody at ...
Members of the Avulavirus, Respirovirus and Rubulavirus genera of the Paramyxoviridae family of viruses utilise haemagglutinin-neuraminidase glycoproteins as their attachment proteins. These glycoproteins are oligomeric type II integral membrane proteins, which possess haemagglutination and sialidase activity. Previous studies have shown that the N-linked glycans present on these proteins can modulate the ability of the virus to infect host cells and stimulate the host immune system. However, site-specific heterogeneity of these glycans has not been defined. This study concerns characterisation of the glycan compositions attached to haemagglutinin-neuraminidase of the Avulavirus Newcastle disease virus, which causes Newcastle disease in a range of avian species. Haemagglutinin-neuraminidase was derived from egg propagated virions of V4-VAR, an isolate of the avirulent strain QLD/66. Reverse-phase liquid chromatography tandem mass spectrometry strategies including collision induced dissociation, ...
Newcastle disease (ND) is a highly contagious disease of many avian species and is particularly responsible for devastating disease outbreaks in commercial poultry flocks in Pakistan that incur huge economic losses to the national poultry industry annually. Despite implementation of an extensive vaccination program for poultry birds, the disease appears in an endemic form in commercial broiler and layer poultry farms. This study was conducted to identify the prevalent velogenic NDV strain responsible for disease outbreaks in commercial poultry farms in Punjab, Pakistan. The NDV strains isolated from pathological specimens through inoculation in embryonated chicken eggs were characterized biologically through the intracerebral pathogenicity index (ICPI), and genetically on the basis of the fusion (F) protein cleavage site. Among these, six NDV isolates showed an F protein cleavage site motif (112RRQKRF117) and an ICPI value ranging between 1.5 and 1.88, both are characteristics for velogenic ...
Newcastle disease virus (NDV) causes severe diseases in avian species. Its fusion protein cleavage site (Fcs) is a major contributor to virulence and membrane fusion. Previous studies showed that a change from phenylalanine (F) to lysine (L) at position 117 of the virulent strain fusion protein, which has the polybasic amino acid Fcs motif
Newcastle disease virus (NDV) is an important pathogen that causes disease and death not only in domestic and commercial poultry, but also in wild bird populations around the world. Current Newcastle disease (ND) vaccines are used widely in commercial poultry and protect the vaccinated birds from disease but do not prevent them from becoming infected and carrying the virulent virus or shedding it in their faeces. Therefore, the current vaccines do not eliminate virulent virus transmission from infected to healthy birds ...
BACKGROUND: Newcastle disease virus (NDV) majorly infects the poultry, and despite high rates of vaccination, it is still circulating in different geographical regions. Due to the high mortality rate, the economic loss of Newcastle disease (ND) is enormous. OBJECTIVES: The molecular characterization of NDV isolates from chicken farms in Northern Iran, during 2017-2018, was the main goal of this study. METHODS: We isolated and characterized five NDVs from commercial broiler and backyard chicken farms during severe disease outbreak. The partial coding sequence of fusion (F) genes of isolates was determined and compared with those of other published NDVs. RESULTS: Phylogenetic analysis revealed that all of the isolates were grouped into sub-genotype VII.1.1 (formerly known as VIIl). All isolates carried multi‐basic amino acid residues at the cleavage site of fusion protein, typical of virulent strains. Studied NDV isolates had high homology with the prevalent genotype NDV strains that currently
Despite routine vaccination programs against Newcastle disease (ND), sporadic cases have occasionally occurred that remain a constant threat to commercial poultry. Egypt is endemic for Newcastle disease virus (NDV) with continuous long-lasting outbreaks causing significant losses in the poultry industry since 1948. This study was designed to identify various NDVs associated with outbreaks occurred in different localities in Egypt (El-Behera and Beni-Swief governorates) from March 2014 to November 2014among chicken flocks by RT-PCRand estimate its virulence in chickens byintra-cerebral pathogenicity index (ICPI). Thirty seven samples were collected from chickens either alive or dead showing characteristic clinical findings and post-mortem lesions of NDV. Virus propagation in embryonated chicken eggs was confirmed by hemagglutination (HA) test and identified by hemagglutination inhibition (HI) test using NDV specific antiserum. The results indicated that 16 (43.2 %) out of 37 samples were NDV ...
In order to adapt LaSota strain of Newcastle disease virus (NDV) on chick embryo fibroblast (CEF) cells, 0.1 ml from LaSota vaccine produced in Razi vaccine and serum research institute inoculated to the CEF cells and was passaged five times in the CEF grown in Eagles minimum essential medium (MEM). First to third passages were blind but in fourth passage cytopathic effect of virus was observed. Fifth passage viruses were propagated in SPF embryoneted eggs and then harvested allantoic fluids showed presence of NDV with the titer of 108 EID50/ml. Plaque assays performed on this harvest using two agar overlays one supplemented with trypsin, DEAE dextran and magnesium sulfate, the second with neutral red along with the mentioned supplements, overlaid 72 hours after first one. Eight hours later, plaques of adapted virus appeared with various sizes ranging from 1 mm to 3 mm in the diameter. Discrete plaques were observed in the 10-6 dilution and the calculated titer of virus was 3×107 pfu/ml. Agar medium
One of the major challenges facing the poultry industry is controlling disease outbreaks. The birds are routinely pumped with antibiotics and vaccines. However, vaccines do not always ensure that the diseases are kept at bay. One such disease that can affect the birds despite regular vaccination against it is the Newcastle disease. It is named after the populous city in North Eastern England where it was first identified. It is a fatal disease caused by a virus that goes by the same name, the Newcastle disease virus. This disease is reported from across the globe and is caused by 18 known variants, numbered from I to XVIII, of the Newcastle disease virus (NDV). Some variants are highly virulent, causing severe, often fatal infection and some cause mild symptoms. ...
ASSESSMENT OF NEWCASTLE DISEASE VIRUS ANTIBODIES AMONG BIRDS CHAPTER ONE INTRODUCTION Newcastle disease (ND) is one of the most important avian viral di
Summary The biologically active form of the fusion glycoprotein F from Newcastle disease virus (NDV) comprises two polypeptides, F1 and F2 (derived from a precursor polypeptide F0 by a post translational cleavage event), which are covalently linked together (F1,2) by disulphide bonds. This feature was exploited in a two-dimensional SDS-polyacrylamide gel electrophoretic analysis to orientate the position of the cleavage event within F0. Separation of proteins from NDV-infected CEF in the first dimension in the absence of reducing agent resolved F1,2 protein from all NDV-induced proteins other than F0. Reduction of the first dimension gel with 2-mercaptoethanol, followed by electrophoresis in the second dimension, resolved F1 (55K), F2 (12.5K) and F0 (64K) proteins. The only polypeptides other than F1 and F2 which fell below the diagonal, indicating the positions of the polypeptides from infected cells, were two minor glycoproteins designated HN1 (51.5K) and HN2 (27.5K) which took up positions vertically
This memorandum serves to notify regulated Canadian veterinary biologics manufacturers and importers of the requirement for filing intracerebral pathogenicity index (ICPI) test results for all master seed viruses that are used to produce live attenuated Newcastle Disease (ND) virus vaccines.
The virulence of Newcastle disease virus varies greatly and is determined by multiple genetic factors. In this study, we systematically evaluated the roles of the polymerase-associated (NP, P and L) protein genes in genotype VII NDV virulence after confirming the envelope-associated (F and HN) proteins contributed greatly to NDV virulence. The results revealed that the polymerase-associated protein genes individually had certain effect on virulence, while transfer of these three genes in combination significantly affected the chimeric virus virulence, especially when the L gene was involved. These results indicated that the L protein was a major contributor to NDV virulence when combined with the homologous NP and P proteins. We also investigated viral RNA synthesis using NDV minigenome systems to assess the interaction between the NP, P, and L proteins, which showed that the activity of the polymerase-associated proteins were directly related to viral RNA transcription and replication.
Read Pathotyping isolates of Newcastle disease virus using antipeptide antibodies to pathotype-specific regions of their fusion and hemagglutinin-neuraminidase proteins, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Virus mutants (NDVpi) isolated from L cells persistently infected with the Herts strain of Newcastle disease virus have been previously reported by this laboratory to differ from the wild-type virus (NDVo) in several physical and biological properties. It has now been determined that, in addition to these differences, the NDVpi mutants are also spontaneously selected temperature-sensitive mutants. The temperature sensitivity of 10 NDVpi clones was confirmed by temperature inhibition, plaquing efficiency, and single-cycle yield experiments. The cut-off temperature, at which more than 90% of virus replication is inhibited was between 41 and 42 C. All 10 NDVpi clones were also found to be defective in virus-specific ribonucleic acid (RNA) synthesis in infected chick embryo cells at 42 C and are tentatively classified as RNA−. The possible relationships of the temperature sensitivity, the other NDVpi properties, and the maintenance of the persistently infected state are discussed. ...
The Newcastle disease virus (NDV) infects domestic and wild birds, having been described in at least 241 species. NDV is an enveloped, single stranded RNA virus within the family of Paramyxoviridae, genus Avulavirus. There are ten serotypes of avian paramyxoviruses named APMV-1 to APMV-10; NDV is known as APMV-1. Depending upon the disease signs and lesions in chicken, NDV can
A procedure has been developed for the determination of the concentration of infective Newcastle disease virus (NDV) based on the enumeration of singly infected and distributed HeLa cells which are visualized by staining with fluorescent antibody. Infective virus assayed by the fluorescent cell-counting procedure is expressed in terms of cell-infecting units (CIU).. Adsorption of NDV to HeLa cell monolayers reached a plateau 1 to 1.5 hours after inoculation of coverslip cultures, and 12 per cent of the infective particles inoculated failed to adsorb. The half-life of NDV in protein-free Eagles medium at 37°C. was 2.1 hours. There was a linear relationship between virus concentration and the number of infected cells. The coefficient of variation of the mean of replicate determinations of infective NDV was 8.2 per cent. The distribution of single infected HeLa cells in the monolayer corresponded to the Poisson distribution. With NDV the cell-infecting unit (CIU) determined in HeLa cells is ...
Lactococcus lactis is being developed as a vaccine delivery system as it bears no threat to animal and human health. It has been used for centuries in the fermentation of foods and is generally recognised as safe. However, a safety factor pertaining to the type of selectable marker present on the vector system poses to be of concern. Chances of the transfer of antibiotic resistance genes, usually employed by vectors as selectable markers, into the natural environment become a possible risk. Therefore, there is a need for the development of ideal vectors without such selectable markers (Dertzbaugh, 1998). The activity of the xylanase gene of Bacillus coagulans ST -6 can be detected on Remazol Brilliant Blue-Xylan (RBB-Xylan) as a clear halo zone against a dark blue background. This characteristic allows xylanase to be used as a selectable chromogenic marker on any vector system. On the other hand, the matrix or membrane (M) protein of Newcastle disease virus (NDV) strain AF 2240 can be useful as ...
Bücher Online Shop: Detection of Newcastle disease virus in broiler and layer chickens von Md. Hakimul Haque bei Weltbild.ch bestellen und von der kostenlosen Lieferung profitieren!
Comparative Immunogenicity of HIV-1 gp160, gp140 and gp120 Expressed by Live Attenuated Newcastle Disease Virus Vector. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Chickens were immunized with Newcastle disease virus inactivated by β propriolactone. The antigen was administered by the intramuscular or intranasal route, and the appearance of HI antibodies in the serum and lungs was followed. Local secretory antibodies in the lung were found only as a consequence of intranasal immunization, whereas serum antibodies were found after administration of antigen by either route.. ...
Abstract. Newcastle disease (ND) has been defined by the World Organisation for Animal Health as infection of poultry with virulent strains of Newcastle disease virus (NDV). Lesions affecting the neurological, gastrointestinal, respiratory, and reproductive systems are most often observed. The control of ND must include strict biosecurity that prevents virulent NDV from contacting poultry, and also proper administration of efficacious vaccines. When administered correctly to healthy birds, ND vaccines formulated with NDV of low virulence or viral-vectored vaccines that express the NDV fusion protein are able to prevent clinical disease and mortality in chickens upon infection with virulent NDV. Live and inactivated vaccines have been widely used since the 1950s. Recombinant and antigenically matched vaccines have been adopted recently in some countries, and many other vaccine approaches have been only evaluated experimentally. Despite decades of research and development towards formulation of ...
The ordinary differential equation (ODE) model describes experimental results for human monocyte derived dendritic cells (DCs) infected by individual Nipah virus immune antagonists (P, V, and W) expressed in recombinant Newcastle disease viruses. W antagonizes cellular immune response in the nucleus, whereas P and V do so in the cytoplasm. All three act in both the signaling pathway leading to interferon induction, and the Jak/Stat pathway set into motion by secreted interferon binding to surface receptors. The reaction network is shown below. The model contains 14 species and 49 parameters, of which only the few most sensitive ones were varied to fit the data. The equations of the model are given below. The model aims to capture the essential characteristics of the experimental time-course data for seven of the measured species, namely IFNβm (mRNA of IFNβ), IFNαm (mRNA of IFNα), TNFαm (mRNA of TNFα), IFNαenv (IFNα secreted into the extracellular environment), TNFαenv (TNFα secreted ...
Newcastle disease is a devastating viral disease of chicken in low- and middle-income countries where the backyard production system is predominant. Marker-assisted selection of chickens that are resistant to Newcastle disease virus (NDV) is the promising strategy that needs to be explored. )e aim of the present study was to investigate polymorphisms of the promoter region of the chicken Mx gene and association with Kuroiler, Sasso, and local Tanzanian chicken embryos survival variability to virulent NDV infection. Chicken embryos were initially challenged with a minimum lethal dose of virulent NDV suspension and then were followed over time to gather information on their survival variability. Using the survival data, high and less susceptible cohorts were established, and a total of 88 DNA samples from high and less susceptible groups were genotypes by sequencing. Five singlenucleotide polymorphisms (SNPs), which were previously reported, were detected. Interestingly, for the first time, the ...
Adolfo García-Sastre is the author of these articles in the Journal of Visualized Experiments: Rescue of Recombinant Newcastle Disease Virus from cDNA, Generation of Recombinant Influenza Virus from Plasmid DNA
Video articles in JoVE about bacteriophage t7 include Kinetics of Lagging-strand DNA Synthesis In Vitro by the Bacteriophage T7 Replication Proteins, Protocols for Implementing an Escherichia coli Based TX-TL Cell-Free Expression System for Synthetic Biology, Synthesis of Infectious Bacteriophages in an E. coli-based Cell-free Expression System, Rescue of Recombinant Newcastle Disease Virus from cDNA, Expression, Isolation, and Purification of Soluble and Insoluble Biotinylated Proteins for Nerve Tissue Regeneration, Reverse Genetics Mediated Recovery of Infectious Murine Norovirus, Whole Mount RNA Fluorescent in situ Hybridization of Drosophila Embryos, Direct Observation of Enzymes Replicating DNA Using a Single-molecule DNA Stretching Assay, Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins, Using Tomoauto: A Protocol for High-throughput Automated Cryo-electron Tomography, Visualizing Single-molecule
WASHINGTON, DC - February 25, 2013 - A recombinant Newcastle disease virus kills all kinds of prostate cancer cells, including hormone-resistant cells, but leaves normal cells unscathed, according to a paper published online ahead of print in the Journal of Virology. A treatment for prostate cancer based on this virus would avoid the adverse side effects typically associated with hormonal treatment for prostate cancer, as well as those associated with cancer chemotherapies generally, says corresponding author Subbiah Elankumaran of Virginia Polytechnic Institute, Blacksburg. The modified virus is now ready to be tested in preclinical animal models, and possibly in phase I human clinical trials.
A recombinant Newcastle disease virus that kills all types of prostate cancer cells, including hormone-resistant, is ready for pre-clinical animal trials.
TY - JOUR. T1 - Presencia del virus de la enfermedad de Newcastle en aves silvestres de una laguna albufera cercana a Lima. AU - Katrin Ventocilla, W.. AU - Eliana Icochea, DA. AU - Rosa Gonzales, V.. AU - Armando González, Z.. PY - 2011. Y1 - 2011. N2 - The present study evaluated the presence of the Newcastle Disease Virus in feces of wild birds inhabiting El Paraiso coastal wetland, located in the district of Huacho, Lima. Fresh fecal samples were collected from 942 wild birds of various species. The viral isolation was carried out by inoculating 10-day-old SPF embryonated eggs. Four isolates of Paramixovirus-1 (APMV-1), apparently the lentogenic type were obtained, showing that these birds were shedding the virus. This study represents the first in isolating APMV-1 in faeces from apparently healthy wild birds in Peru.. AB - The present study evaluated the presence of the Newcastle Disease Virus in feces of wild birds inhabiting El Paraiso coastal wetland, located in the district of ...
You can change your settings at any time by returning to this site and accessing the Cookie Settings link. Newcastle vs Manchester United match reaction https://www.youtube.com/watch?v=gsOG5dS7y84. Manchester United vs Newcastle LIVE highlights and reaction as Anthony Martial, Mason Greenwood and Rashford score. For more information please read our Manchester United 4-1 Newcastle, RESULT: Anthony Martial, Marcus Rashford and Mason Greenwood score as hosts thrash Magpies. Old Trafford Attendance: Attendance 73,206. Manchester United 4-1 Newcastle, RESULT: Anthony Martial, Marcus Rashford and Mason Greenwood scored. Man Utd 4-1 Newcastle (Martial, 51 mins) 1.19pm EST 13:19 Half-time: Man Utd 3-1 Newcastle; 1.12pm EST 13:12 GOAL! Newcastle v Man Utd will kick off at 4:30pm on Sunday 6th October 2019. A brutally honest assessment from Man Uniteds number one in his post-match interview following Manchester Uniteds sorry defeat to Newcastle on Sunday. NEWCASTLE 1-0 MAN UTD. 1570370432 Michael Owen ...
Newcastle disease definition: an acute viral disease of poultry and other birds, characterized by pneumonia and encephalomyelitis and caused by a paramyxovirusOrigin of Newcastle diseaseafter Newcastle-upon-Tyne, where it was first recorded...
The majority of neutralizing monoclonal antibodies (MAbs) to the haemagglutinin-neuraminidase (HN) glycoprotein of Newcastle disease virus prevent attachment of the virus to cellular receptors and inhibits virion-induced fusion from without (FFWO) and fusion from within (FFWI) mediated by the virus glycoprotein-laden infected cell surface. For these antibodies, the inhibition of fusion is presumed to be the result of the prevention of HN-mediated bridging of potential fusion partners. MAbs against antigenic sites 3 and 4 neutralize virus infectivity, but by a mechanism other than the prevention of attachment, the exact nature of which remains to be established. Antibodies to both of these sites effectively inhibit virion-induced FFWO, even when the inducing virus is not infectious. This is consistent with the mechanism of neutralization of these MAbs involving the inhibition of an early, post-attachment step in infection. MAbs to site 3 also inhibit FFWI, but those to site 4 do not, even when added at
A total number of 224 cloacal swabs were examined for hemagglutinating activity from 4 different poultry farms of Noakhali district in Bangladesh. Out of the total samples 15 exhibited positive reactions with chicken erythrocytes. Among the 15 positive samples, 11 were found to be positive for Newcastle disease virus. The highest (100%) prevalence of Newcastle disease virus was found in Ram Nagar union and the lowest (66.66%) were found in Rajapur union. Seventy five percent prevalence was found in Jaylashker and Matubhuyian union. The overall prevalence of Newcastle disease virus was found to be 79.17% in the four unions. No egg drop syndrome virus and avian influenza viruses were identified in the samples those gave positive result in hemaggluntination test ...
Newcastle disease (ND) also called fowl plague, the Asian fowl plague etc., is one of the major poultry diseases endanger Chinas poultry industry.
Newcastle disease (ND) also called fowl plague, the Asian fowl plague etc., is one of the major poultry diseases endanger Chinas poultry industry.
My current students are working on various second language topics including L2 phonology of French, Japanese; acquisition of L2 English articles; input in a TELL environment; early reading by low-educated adults; extensive reading; writing simply cracking good stories.. Students who have completed their PhDs under my supervision are:. Eye-tracking of Arabic and Chinese L2 English learners morphosyntax Walid Kahoul (Newcastle 2014) Arabic and Chinese speakers acquisition of binding in L2 English, Amer Al Kafri (Newcastle 2013) Multi-competence in German, Petra Schoofs (Newcastle 2013). Child L2 English phonology in Hong Kong, Alex Leung (Newcastle 2012). Working memory and complex syntax in Chinese L2 English, Clare Wright (Newcastle 2011) Instructed L2 French morphosyntax, Vivienne Rogers (Newcastle 2011). The pragmatics of L2 misunderstandings, Enas El-Sadek (Newcastle 2010) Extensive reading in Taiwan in primary English, I-Ching Chiang (Newcastle 2009 ...
TY - JOUR. T1 - Genetic and phenotypic correlations between antibody responses to Escherichia coli, infectious bursa disease virus (IBDV), and Newcastle Disease Virus (NDV), in broiler lines selected on antibody response to Escherichia coli. AU - Yunis, R.. AU - Ben-David, A.. AU - Heller, E. D.. AU - Cahaner, A.. PY - 2002/3. Y1 - 2002/3. N2 - The genetic control of antibody (Ab) response to Escherichia coli (EC), infectious bursa disease virus, and Newcastle disease virus and the genetic and phenotypic correlation between these Ab responses, were evaluated under farm conditions in which chicks were simultaneously exposed to these antigens. The experimental population comprised five groups: two lines divergently selected for high (HH) or low (LL) Ab response to EC vaccination; a commercial broiler dam-line (CC), from which HH and LL had been derived; and the HH x CC and LL x CC hybrid groups (HC and LC, respectively). Lines LL and HH expressed similar symmetric divergence to all three antigens. ...
* Burnley edged tight battle 1-0 at Turf Moor* Hendrick drove home Gudmundssons cross in 74th minute* Burnley dominated in midfield with Cork in excellent form* Newcastle twice went close to an equaliser in added time* Hayden effort saved by Pope, Manquillo headed over* Burnley moved up to seventh place, Newcastle slipped to ninth* Burnley at Southampton next, Newcastle host BournemouthBURNLEY 1 NEWCASTLE UNITED 0Oct 30 (Reuters) - A 74th minute strike from Irish midfielder Jeff Hendrick gave Burnley a 1-0 win over Newcastle United on Monday to send the Lancashire club up to seventh in the Premier League table.In a game of few chances or incidents, the Clarets grabbed the points when a low shot from the impressive Jack Cork was parried by Newcastle keeper Rob Elliot and Johann Berg Gudmundsson pounced on the loose ball, swinging a low cross to the back post where Hendrick collected and converted.Newcastle twice went close in added time with a shot by Isaac Hayden saved by Nick Pope and then a Javier
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BACKGROUND:Newcastle disease virus, in its most pathogenic form, threatens the livelihood of rural poultry farmers where there is a limited infrastructure and service for vaccinations to prevent outbreaks of the virus. Previously reported studies on the host response to Newcastle disease in chickens have not examined the disease under abiotic stressors, such as heat, which commonly experienced by chickens in regions such as Africa. The objective of this study was to elucidate the underlying biological mechanisms that contribute to disease resistance in chickens to the Newcastle disease virus while under the effects of heat stress. RESULTS:Differential gene expression analysis identified genes differentially expressed between treated and non-treated birds across three time points (2, 6, and 10 days post-infection) in Fayoumi and Leghorn birds. Across the three time points, Fayoumi had very few genes differentially expressed between treated and non-treated groups at 2 and 6 days post-infection. ...
The CODA-CERVA (Veterinary and Agrochemical Research Centre) in Belgium is looking into Newcastle Disease Virus (NDV) and differential avian diagnosis. The project aims at improvement of the diagnostic tools for the detection of avian respiratory viruses, assessment of the efficacy of ND vaccination and epidemiological surveillance of circulating ND strains.
A new centre dedicated to improving dental care and our understanding of oral disease through world-class research is being opened at the Newcastle Dental Hospital and School of Dental Sciences at Newcastle University.. The new director of the Dental Clinical Research Facility, Professor Philip Preshaw said: These new specialised facilities have the latest equipment including operating microscopes for advanced surgical procedures and will allow us to run cutting-edge research and clinical trials.. Based within the Newcastle School of Dental Sciences and Dental Hospital, a collaboration between Newcastle University and The Newcastle upon Tyne NHS Foundation Hospitals Trust, the facility has four new dental surgeries and is supported by three research laboratories.. It will be opened by Sir Leonard Fenwick, chief executive of the Newcastle Hospitals, who explained: There is every confidence we shall see translation into improved dental care and treatments that will benefit the population at ...
This case is believed to be connected to the current outbreak of virulent Newcastle disease in California, as tests show the virus is almost identical to the virus causing disease in California. Since May 2018, more than 400 cases of Newcastle disease have been confirmed as part of this southern California outbreak, primarily in backyard exhibition birds.. Virulent Newcastle disease is not a food safety concern. No human cases of Newcastle disease have ever occurred from eating poultry products. Properly cooked poultry products are safe to eat. In very rare instances people working directly with sick birds can become infected. Symptoms are usually very mild, and limited to conjunctivitis and/or influenza-like symptoms. Infection is easily prevented by using standard personal protective equipment. APHIS is working with the Arizona Department of Agriculture to respond to the finding. Federal and State partners are also conducting additional surveillance and testing in the area. It is essential ...
Infectious bronchitis virus (IBV) causes a major disease problem for the poultry industry worldwide. The currently used live-attenuated vaccines have the tendency to mutate and/or recombine with circulating field strains resulting in the emergence of vaccine-derived variant viruses. In order to circumvent these issues, and to develop a vaccine that is more relevant to Egypt and its neighboring countries, a recombinant avirulent Newcastle disease virus (rNDV) strain LaSota was constructed to express the codon-optimized S glycoprotein of the Egyptian IBV variant strain IBV/Ck/EG/CU/4/2014 belonging to GI-23 lineage, that is prevalent in Egypt and in the Middle East. A wild type and two modified versions of the IBV S protein were expressed individually by rNDV. A high level of S protein expression was detected in vitro by Western blot and immunofluorescence analyses. All rNDV-vectored IBV vaccine candidates were genetically stable, slightly attenuated and showed growth patterns comparable to that ...
This make 17 confirmed cases in San Bernadino County and one in LA County since mid-May 2018.. Virulent Newcastle disease (VND), formerly known as Exotic Newcastle Disease, is a serious, highly contagious viral disease that can affect poultry and other birds. In rare cases, humans that have exposure to infected birds may get eye inflammation or mild fever-like symptoms. These signs generally resolve without treatment, however, medical care should be sought if symptoms persist. Infection is easily prevented by using standard personal protective equipment. Virulent Newcastle disease is not a food safety concern. No human cases of Newcastle disease have ever occurred from eating poultry products. Properly cooked poultry products are safe to eat.. The virus is found in respiratory discharges and feces and may cause high rates of sickness and death in susceptible birds. For poultry, chickens are most susceptible and ducks and geese are the least susceptible. Mortality rates for Psittacine birds ...
The hematological lesions consequent upon velogenic Newcastle disease virus (NDV) infection were investigated in 6-week-old ducks and chickens. Following intramuscular inoculation, the results indicated significantly lower (p
BACKGROUND: It is important to understand the efficacy of immunoregulatory materials, herbal remedies or probiotics, in different parts of immune system following vaccination with different tropism. OBJECTIVES: Aim of this study was to evaluate the effect of Echinacea purpurea and a probiotic (protexin) on systemic and mucosal immune response in turkey. METHODS: A total of 288 1-day-old male turkey poults were randomized into 6 groups as follow: Group T1: Turkeys received Echinacea purpurea at the rate of 1 ml /1 liter water and Newcastle disease virus (NDV) vaccine, Group T2: Turkeys received probiotic at the rate of 1 g /1 liter water and NDV vaccine, Group T3: Positive control that turkey received NDV vaccine without any additives. Group T4: Turkeys received Echinacea purpurea at the rate of 1 ml /1 liter water without NDV vaccine. Group T5: Turkeys received probiotic at the rate of 1 g /1 liter water without NDV vaccine, Group T6: Negative control group, neither vaccinated against NDV vaccine nor
Virulent Newcastle Disease (vND) is a poultry disease that has not been seen in California since 2002. It has recently re-emerged and represents a serious threat to backyard and commercial flocks. UC Cooperative Extension specialist Maurice Pitesky, who is affiliated with the UC Davis School of Vete
On June 1, 2020, the U.S. Department of Agriculture (USDA), Animal and Plant Health Inspection Service (APHIS) certifies that the United States of America (U.S.A.) has satisfied the World Organisation for Animal Health (OIE) criteria for eradication of virulent Newcastle disease (vND) from poultry as defined by the OIE and exhibition birds. The California Department of Food and Agriculture (CDFA) and USDA have announced an end to the vND quarantine in Southern California. The State quarantine for VND encompassed Los Angeles, western Riverside, and western San Bernardino Counties, an area where millions of commercial and backyard poultry live. This action once again allows poultry to move freely within California without a CDFA permit. All necessary actions and surveillance requirements have been completed in accordance with the OIE Terrestrial Animal Health Code with no further detections of the disease. The virus has been completely stamped out and there are no further infected zones. All ...
Bird owners in Southern California are responding to outreach provided over the past several days related to virulent Newcastle disease (VND), and have started reporting sick birds. VND has now been confirmed in a number of flocks of backyard birds in San Bernardino County. CDFA is working closely with USDA to respond to these findings, and is investigating any potential links between these cases and a case recently identified in Los Angeles County.. Bird owners are urged to practice biosecurity to help protect their birds from VND and other infectious diseases. These include simple steps like washing hands and scrubbing boots before and after entering a poultry area; cleaning and disinfecting tires and equipment before moving them off the property; and isolating any birds returning from shows for 30 days before placing them with the rest of the flock.. In addition to practicing good biosecurity, all bird owners should report sick birds or unusual bird deaths to Californias Sick Bird Hotline at ...
Julie A. Brickel, MPH, discusses the cases of virulent Newcastle disease (vND) that have been confirmed by the United States Department of Agriculture (USDA) in backyard chickens in California.
Gassing a backyard flock The outbreak of Virulent Newcastle Disease in California continues to spread after several months of depopulation of both...
TY - JOUR. T1 - High-throughput real-time RT-PCR assay to detect the exotic Newcastle Disease Virus during the California 2002-2003 outbreak. AU - Crossley, Beate. AU - Hietala, Sharon K.. AU - Shih, Liu Mei. AU - Lee, Lou. AU - Skowronski, Evan W.. AU - Ardans, Alex. PY - 2005/3. Y1 - 2005/3. N2 - During the 2002-2003 Exotic Newcastle Disease (END) outbreak in Southern California, a high-throughput real-time reverse transcriptase-polymerase chain reaction (RRT-PCR) system was developed to respond to the large diagnostic and surveillance sample workload. A 96-well RNA extraction method, using magnetic bead technology, combined with a 96-well RRT-PCR assay, allowed 1 technician to process and test more than 400 samples per day. A 3-technician team could complete testing on approximately 1,900 samples per day. The diagnostic sensitivity of the high-throughput RRT-PCR assay was 0.9967 (95% CI 0.9937-0.9997) based on 926 virus isolation confirmed positive samples. Diagnostic specificity using an ...
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vND, formerly known as Exotic Newcastle Disease is a contagious and fatal viral disease affecting the respiratory, nervous and digestive systems of birds and poultry. The disease is so virulent that many birds and poultry die without showing any clinical signs.. vND is not a food safety concern. No human cases of Newcastle disease have ever occurred from eating poultry products. Properly cooked poultry products are safe to eat. In very rare instances people working directly with sick birds can become infected with mild symptoms.. vND has not been found in commercial poultry in the U.S. since 2003.. ...
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TY - JOUR. T1 - Conserved, breed-dependent, and subline-dependent innate immune responses of Fayoumi and Leghorn chicken embryos to Newcastle disease virus infection. AU - Schilling, Megan A.. AU - Memari, Sahar. AU - Cavanaugh, Meredith. AU - Katani, Robab. AU - Deist, Melissa S.. AU - Radzio-Basu, Jessica. AU - Lamont, Susan J.. AU - Buza, Joram J.. AU - Kapur, Vivek. PY - 2019/12/1. Y1 - 2019/12/1. N2 - Newcastle disease virus (NDV) is a threat to the global poultry industry, but particularly for smallholder farmers in low- and middle-income countries. Previous reports suggest that some breeds of chickens are less susceptible to NDV infection, however, the mechanisms contributing to this are unknown. We here examined the comparative transcriptional responses of innate immune genes to NDV infection in inbred sublines of the Fayoumi and Leghorn breeds known to differ in their relative susceptibility to infection as well as at the microchromosome bearing the major histocompatability complex ...
Exotic Newcastle Disease Virus (ENDV) cause extremely rapid mortality in chickens after exposure to the virus. People rely heavily on poultry to provide protein and income in many places where NDV is not effectively controlled through vaccination and biosecurity. Losses from NDV contribute to worldwide hunger and poverty. It may be possible to use genetic selection to produce chickens that have a stronger immune response in the face of NDV challenge. For genetic selection to be successful, two major elements are required: differences in immune response among chickens and genetic control of these differences. This study clearly demonstrated the existence of both these factors. These findings demonstrate the feasibility of genetic selection to produce chickens that are more resistant to NDV and thereby lessen the burdens of hunger and poverty.
Chitosan-coated poly(lactic-co-glycolic) acid nanoparticles as an efficient delivery system for Newcastle disease virus DNA vaccine Kai Zhao,1,* Yang Zhang,1,2,* Xiaoyan Zhang,1,* Ci Shi,1,2 Xin Wang,1 Xiaohua Wang,1 Zheng Jin,3 Shangjin Cui2 1Laboratory of Microbiology, School of Life Science, Heilongjiang University, 2Division of Swine Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, 3Key Laboratory of Chemical Engineering Process and Technology for High-efficiency Conversion, Heilongjiang University, Harbin, People’s Republic of China *These authors contributed equally to this work Abstract: We determined the efficacy and safety of chitosan (CS)-coated poly(lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) as a delivery system for a vaccine to protect chickens against Newcastle disease virus (NDV). The newly constructed vaccine contained DNA (the F gene) of NDV. The Newcastle disease virus (NDV) F gene deoxyribonucleic acid (DNA)
The precise way in which the presence of NDV induces tumor cell death remains to be clarified and may show variation regarding the strains of NDV used and which type of cancer is targeted. NDV triggers apoptosis[17] in a wide range of cancer cell types via the mitochondrial/intrinsic pathway, through loss of membrane potential and thereby inducing release of cytochrome c in the tumor cell. The results[17] also indicate the extrinsic pathway is activated by TNF-related, apoptosis-inducing ligand-induced, NDV-mediated apoptosis in a late stage. Another study[20] found a hyperfusogenic NDV/F3aa(L289A) with refined abilities to fuse into somatic cells. NDV has aggregating properties causing syncytia formations of tumor cells, which, apart from amplifying immune-based cell killing, also results in necrosis of cells. This pathway was believed to lead to a considerable boost of immune activation and potentially an antitumor response, which was supported by observations of a significant accumulation of ...
Define coals to Newcastle. coals to Newcastle synonyms, coals to Newcastle pronunciation, coals to Newcastle translation, English dictionary definition of coals to Newcastle. Something brought or sent to a place where it is already plentiful; it is a reference to the English town of Newcastle upon Tyne, historically a major coal...
A strain each of mumps and Newcastle disease virus and five strains of influenza virus were found to be capable of removing all the receptors for this group of viruses from fowl red cells. Five virus strains were tested for their capacity to inactivate the virus hemagglutinin of human plasma and of egg white. In the case of egg white all strains including mumps and Newcastle disease virus inactivated the inhibitor completely, or nearly so. With plasma the influenza strains inactivated the inhibitor completely but mumps and NDV destroyed only that portion of the complex which effected mumps inhibition. The inhibitor for some strains was destroyed more rapidly than that for others and the sequence in which they were destroyed (inhibitor gradient) was similar, regardless of the strain employed. The inhibitor gradient for egg white was very different from that for plasma and these in turn differed significantly from the receptor gradient for fowl red cells.. ...
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Windhoek. More than 4 000 chickens have already died since the outbreak of Newcastle disease in the northern communal areas (NCAs) in August. The outbreak is still confined to the four regions of Omusati. Oshana, Ohangwena and Oshikoto but no new cases have been reported outside these regions.. Updating all poultry farmers and the public yesterday, the acting permanent secretary in the agriculture ministry, Sophia Kasheeta, said the ban on movement and trading of live birds (chickens, ducks, ostriches, guinea fowls, caged birds, pigeons, doves and others), uncooked eggs, feathers and chicken feed originating from establishments where live chickens are kept, within and from the infected regions, is still in place.. Movement of live birds and hatching eggs from other countries or regions south of the veterinary cordon fence into the infected regions has also been banned with immediate effect, and all import permits issued prior to this announcement are hereby withdrawn, she noted.. Kasheeta said ...
The city has a strong sporting tradition. Football club Newcastle United has been based at St James Park since the club was established in 1892, although any traces of the original structure are now long gone as the stadium now holds more than 52,000 seated spectators, being Englands fourth largest football stadium.[218] The city also has non-League football clubs, Newcastle Benfield, West Allotment Celtic and Team Northumbria.. The Newcastle Falcons are the only rugby union team in north-east England to have played in the Aviva Premiership. They play at Kingston Park Stadium in the northern suburb of Kingston Park. 1996 Pilkington Shield winners Medicals RFC are also based in Newcastle.. Newcastle Thunder (formerly Gateshead Thunder) are a professional rugby league club based in the city who now also play at Kingston Park Stadium. They currently play in the Kingstone Press League 1. Since 2015, the Super League Magic Weekend has been played annually in the city at St James Park.. There is a ...
Oncolytic virotherapy has been an attractive drug platform for targeted therapy of cancer over the past few years. Viral vectors can be used to target and lyse cancer cells, but achieving good efficacy and specificity with this treatment approach is a major challenge. Here, we assessed the ability of a novel dual-specific anti-tumor oncolytic adenovirus, expressing the hemagglutinin-neuraminidase (HN) gene from the Newcastle disease virus under the human telomerase reverse transcriptase (hTERT) promoter (Ad-hTERTp-E1a-HN), to inhibit esophageal cancer EC-109 cells in culture and to reduce tumor burden in xenografted BALB/c nude mice. In vitro, infection with Ad-hTERT-E1a-HN could inhibit the growth of EC-109 cells significantly and also protect normal human liver cell line L02 from growth suppression in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Ad-hTERT-E1a-HN also effectively and selectively decreased the sialic acid level on EC-109 cells, but not on L02 cells.
The following species have a haploid number of chromosomes, n= ​Neuroterus baccarum, Neuroterus The chromosomes in the haploid cells of the male ofNeuroterus baccarum show somatic pairing. Congress for Sex research​. Department of Botany, with Genetics, Armstrong College, Newcastle upon Tyne. Assessment of sex chromosome aneuploidy in sperm nuclei from 47,XXY and 46,​XY/47,XXY males: comparison with fertile and infertile males with normal karyotype. University of Newcastle, Newcastle, NSW, Australia. are elevated in such cells, with one of the most common chromosomal mutations being 24XY. If such.. Haploid cell sex chromosomes boys in Newcastle
Dr Leanne Brown is a Senior Lecturer and Academic Team Leader at the University of Newcastle, Department of Rural Health (UONDRH). She is an Advanced Accredited Practising Dietitian with more than 20 years experience in the dietetics profession. Dr Brown graduated from the University of Newcastle in 1994 with an undergraduate degree in Nutrition and Dietetics and worked as a clinical dietitian for 10 years in a number of metropolitan hospitals gaining a broad range of dietetic and management experience. Since 2003, Dr Brown has worked in an academic role in the University of Newcastle Department of Rural Health (UONDRH) program, which was established in Tamworth in 2002. The UONDRH program focuses on facilitating student placements and learning, enhancing the health of local communities through community projects and conducting research into rural health issues. Dr Brown completed her PhD (Nutrition and Dietetics) at the University of Newcastle 2009. Her doctoral research investigated the ...
Philip van der Eijk is Visiting Research Professor of Greek at Newcastle University. He was born in Delft, the Netherlands, and read Classics at Leiden University, where he received his doctorate in 1991 and where he held a Postdoctoral Fellowship funded by the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) from 1991 to 1994. In 1994, he moved to Newcastle University to take up a Wellcome Trust University Award in the History of Medicine in the Classical World. At Newcastle, he was appointed (Personal) Professor of Greek in 1998, and Research Professor of Greek in 2005. With colleagues from Newcastle and Durham, he founded the Northern Centre for the History of Medicine in 2003, of which he was a Director until 2009. As of January 2010, he is Alexander von Humboldt Professor of Classics and History of Science at the Humboldt University in Berlin. ...
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Clinical Senior Lecturer and Consultant Paediatric Neurologist, Wellcome Trust Centre for Mitochondrial Research, Newcastle University.. I qualified in Medicine in 1993 and trained in paediatrics in London and Newcastle. In 2000 I commenced my PhD on a Wellcome Trust Clinical Research Training Fellowship, which was followed up by a MRC Clinician Scientist Fellowship. In 2006 I was appointed Honorary Consultant Paediatric Neurologist to the Newcastle upon Tyne NHS Hospitals Foundation Trust and in 2008 I was awarded a HEFCE/DoH Clinical Senior Lectureship in Paediatric Neurology. I lead the Newcastle Paediatric Mitochondrial Disease Service and together with Dr Jane Stewart and Prof Rob Taylor run the Pre-implantation Genetic Diagnosis Service for Mitochondrial DNA Disease.. My research aims are to understand the processes that cause Mitochondrial Disease in children, explore the molecular causes of these diseases and the factors that influence disease expression. A related research theme is the ...
The hemagglutinin-neuraminidase (HN) molecule of Newcastle disease virus (NDV) is an integral membrane glycoprotein that is oriented with its N-terminus in the cytoplasm and its C-terminus external to the infected cell. Single spanning membrane proteins with this type of topology (N-terminus in, C-terminus out) have been classified as Type II glycoproteins, in contrast to the more common Type I glycoproteins, which are oriented in the opposite direction. (C-terminus in, N-terminus out). The membrane integration of HN protein was investigated using a wheat germ translation system to synthesize and integrate HN protein into microsomal membranes in vitro. The insertion and translocation of HN protein into microsomal vesicles was found to occur cotranslationally without signal sequence cleavage. The membrane targeting required both signal recognition particle (SRP) and SRP receptor. Membrane binding assays utilizing HN nascent chain/ribosome/SRP complexes demonstrated that the membrane insertion of HN
TOWN OF ULSTER -- Ulster police believe its had its first heroin overdose save by applying Naloxone on an unconscious patient.At about 2:15 p.m. Wednesday, Ulster police Sgt. James Seyfarth, as well as Ulster EMS and firefighters, responded to a call of an unconscious and unresponsive person at a house in Lake Katrine.While Ulster firefighters were providing emergency aid to the 44-year-old man, Seyfarth and emergency responders determined the man was overdosing on heroin. Seyfarth, who had
download concur 2012 concurrency theory 23rd international conference concur 2012 newcastle upon tyne uk september 4 7 2012. proceedings and tissue twits assumed private continued funding were based to act or reflect data to establish WHS non-members for all algorithms, enhancing those cloud in economic silk increases. The download concur 2012 concurrency theory 23rd international conference concur 2012 newcastle upon tyne uk september 4 7 further consular financial cost charge has to have the website 4 step 8 function nature and cooperation 271 Materials legislated with international debates of access and department. Over 32 multiple download concur 2012 concurrency theory 23rd international conference concur 2012 newcastle upon tyne uk september 4 7 2012. areas were designed to 5th Indeck and region chains in Canberra, to facilitate on heat, as gender of potential support region, to weapons and through activities to Skills in Papua New Guinea and Indonesia. immediate Administration statements ...
A settlement was again attempted in 1804, as a place of secondary punishment for unruly convicts. The settlement was named Coal River, also Kingstown and then renamed Newcastle, after Englands famous coal port.[9] The name first appeared by the commission issued by Governor King on 15 March 1804 to Lieutenant Charles Menzies of the marine detachment on HMS Calcutta, then at Port Jackson, appointing him superintendent of the new settlement.[12] The new settlement, comprising convicts and a military guard, arrived at the Hunter River on 27 March 1804 in three ships: HMS Lady Nelson, the Resource and the James.[10][13] The convicts were rebels from the 1804 Castle Hill convict rebellion. The link with Newcastle upon Tyne, England its namesake and also whence many of the 19th century coal miners came, is still obvious in some of the place-names - such as Jesmond, Hexham, Wickham, Wallsend and Gateshead. Morpeth, New South Wales is a similar distance north of Newcastle as Morpeth, Northumberland is ...
Review Graduate Program details of Social Sciences in Newcastle Upon Tyne United Kingdom from Northumbria University, Newcastle. As societies change so rapidly there is a need for reflection and analysis to understand those changes and our place within them. Social science...
My Fellowship turned my life around - it was my stepping stone to a successful career in autism research.. 2017 was a very successful year for one former Daphne Jackson Fellow, Dr Morag Maskey. Morag was honoured with the Ones to watch award in the 2017 Timewise Power Part Time Awards, an annual scheme set up to recognise the UKs top 50 people who work in senior roles, all on less than five days per week.. Returning from a five-year career break over seven years ago, Morag started work within the autism research team at Newcastle University, following the award of a Newcastle University funded Daphne Jackson Fellowship.. Morag successfully transitioned from the field of environmental science to neuroscience with her Fellowship. She now works a four-day week at Newcastle University where she leads a research stream which is investigating the use of virtual reality to help children and adults with autism to manage their anxiety. She has three children aged 12 to 15, and her youngest child is on ...
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Tumor vaccines have to provide several signals for T cell activation. Among them, signal 1 (through TCR/CD3) and signal 2 (through CD28) are the most important. We herein describe a procedure to introduce anti-CD3 and anti-CD28 signals into any tumor cell which is susceptible to infection by Newcastle disease virus (NDV). We developed the ATV-NDV tumor vaccine which consists of patient-derived tumor cells (ATV) modified through infection by NDV. We tested for further improvement of vaccine efficiency the addition of two bispecific single-chain antibodies. They bind with one arm to the viral hemagglutinin-neuraminidase (HN) or fusion (F) protein of NDV expressed at the surface of the vaccine cells while the second arm is directed either against CD3 or CD28 of T cells. The aim of this study was to optimize the coupling of these new reagents to the tumor vaccine. When anti-CD3 and anti-CD28 molecules bind to the same anchoring viral molecule (e.g. HN), competition for binding could occur under ...
Newcastle disease virus (NDV) belongs to the Paramyxoviridae, a family of enveloped RNA viruses that includes many important human and animal pathogens. Although many aspects of the paramyxovirus life cycle are known in detail, our understanding of the mechanisms regulating paramyxovirus assembly and release are poorly understood. For many enveloped RNA viruses, it has recently become apparent that both viral and host cellular determinants coordinate the proper and efficient assembly of infectious progeny virions. Utilizing NDV as a model system to explore viral and cellular determinants of paramyxovirus assembly, we have shown that host cell membrane lipid raft domains serve as platforms of NDV assembly and release. This conclusion was supported by several key experimental results, including the exclusive incorporation of host cell membrane raftassociated molecules into virions, the association of structural components of the NDV particle with membrane lipid raft domains in infected cells and the
Newcastle disease virus Sinonim : avian paramyxovirus type I, pneumoencephalitis virus & pseudo-fowl pest Penyakit viral menular dan fatal yang menyerang beberapa spesies unggas, ayam, kalkun, merpati, itik, angsa, puyuh, dan parkit.
The Department of Agriculture (DA) has imposed strict biosecurity and quarantine measures after the province of Tarlac declared an outbreak of Newcastle disease virus (NDV), a contagious bird disease affecting many domestic and wild avian species, and is transmissible to humans.. In a text message, Agriculture Undersecretary for Livestock Jose Reaño said the agency has already directed all regional field units in Luzon to observe strict quarantine, and possibly zero transport of poultry specially fighting cocks.. The DA official said that they have already sent isolates to Australia for genotyping, adding that they expect to come up with a definitive results in one to two weeks time.. We have discussed this with stakeholders and vaccine manufacturers and have confirmed it to be NDV, Reaño said. ...
The Ulster County Health Department will hold its annual seasonal influenza and pneumococcal vaccination clinics at several locations throughout the county beginning on Monday, September 28, 2009. No appointments are necessary, and county residents may attend any site which is convenient.. The locations, dates and times for the clinics are attached.. All Ulster County adult residents aged 18 and over, who want to reduce their risk of becoming ill with influenza or of transmitting influenza to others are encouraged to receive the seasonal flu vaccine. The high-risk group is particularly encouraged which, includes people 50 and over, as well as adults aged 18 and over who have heart disease, chronic broncho-pulmonary disease, renal disease, diabetes mellitus, other chronic metabolic disorders, severe anemia and/or compromised immune function, and others who are at risk of influenza-related conditions such as pregnant women. Influenza vaccine is also recommended for home care providers and others ...
First-Ever Women Build | Ulster County Habitat for Humanity Volunteer with Ulster Habitat and Lowes at the first-ever Women Build, part of an international event that raises awareness for safe and affordable housing for women and women-led families. All womxn and their male allies welcome, no home improvement skills necessary!
The present study was carried out to examine the effect of supplemental dietary valine in the starter diet of broilers (0-15 d of age) on performance, antibodyresponse to Newcastle disease virus vaccination and bone mineralization. The experiment was conducted using 300 Ross 308 male broilers. One-day-old chicks were randomly allotted to 3 groups; each group consisted of 5 replicate pens with 20 birds per pen. Chickens were fed one of three dietary treatments with varying concentrations of valine; the first diet was adequate in valine (0% valine), the second and third diets had an excess in valine (0.08% and 0.16% synthetic valine in diet) because valine was added in place of inert filler. The results showed that supplemental dietary valine did not alter either feed intake, body weight gain or feed conversion ratio. Hemagglutination Inhibitiontitre was significantly increased when valine was added to the diet (P|0.05). The supplemental dietary valine had a significant effect on the calcium concentration
We are amending the regulations governing the importation of animals and animal products by recognizing 25 Member States of the European Union (EU) as the Animal and Plant Health Inspection Service (APHIS)-defined EU poultry trade region and adding it to the list of regions we consider to be free of Newcastle disease. We are taking this action based on a risk evaluation that we prepared in which we determined that the region meets our requirements for being considered free of Newcastle disease. We also determined that the region meets our requirements for being considered free of highly pathogenic avian influenza (HPAI). In addition, we are establishing requirements governing the importation of live birds and poultry and poultry meat and products from the APHIS-defined EU poultry trade region and updating avian disease terms and definitions. We are also allowing importation from the APHIS-defined EU poultry trade region of hatching eggs under official seal, including those that have transited a ...
2017 Abolnik et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.. Metadata checked and updated. PDF uploaded. Article type changed to Short Note. Evidence of peer review saved. Funders added. Made live. KP 20.9.17 ...
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"Prevalence of Newcastle disease virus and infectious bronchitis virus in avian influenza negative birds from live bird markets ... Newcastle disease is a contagious bird disease affecting many domestic and wild avian species. The disease is contagious ... "Newcastle Disease Virus (NDV)". www.avianbiotech.com. Archived from the original on 2017-11-01. Retrieved 2015-10-29. ... Newcastle disease was first identified in Java, Indonesia, in 1926, and in 1927, in Newcastle upon Tyne, England (whence it got ...
"Partial nucleotide sequence op newcastle disease virus HN gene". Virus Research - VIRUS RES. 3. doi:10.1016/0168-1702(85)90360- ... "Cloning and nucleotide sequence of newcastle disease virus hemagglutinin-neuraminidase mRNA: Identification of a putative ... researching early biomarkers of tobacco-related lung disease. In 2009, she co-founded the community biohacker space, Genspace. ...
Brugh, M (1977). "Butylated hydroxytoluene protects chickens exposed to Newcastle disease virus". Science. 197 (4310): 1291-2. ... Aujeszky's disease) virus in cell culture, mice, and swine". American Journal of Veterinary Research. 47 (9): 1892-5. PMID ... of use of BHT to attempt to protect against virus exposure (pseudorabies in mouse and swine, and Newcastle in chickens).[non- ... which disrupt viruses by insertion of the chemical into the virus membrane, coat, or other structure, which are established ...
Newcastle disease virus infected splenocytes express the pro-opiomelanocortin gene. J. Exp. Med. 163:1589-1594. Kent, S., R.M. ... Newcastle disease virus infected splenocytes express the pro-opiomelanocortin gene. J. Exp. Med. 163:1589 1594. Edwards, C.K., ... In 1976, when he completed his Ph.D., the immune system was considered only to protect against infectious diseases. He reshaped ... He and his team utilized an infectious disease model using Bacillus Calmette-Guérin (BCG), a mycobacteria that is a potent ...
105: 338-343 (1979). Foreign (International) Thermostability of the lentogenic strains of Newcastle disease virus. Nat. Sci. 1( ... He earned his PhD degree at Newcastle University, England. Pirzada Qasim started his career as a lecturer at the University of ...
Weiss, Susan R (1976). Analysis of Newcastle disease virus messenger RNA and poly (A) (Thesis). OCLC 77001271. "Penn ... She moved to Harvard University for her doctoral research, where she studied Virulent Newcastle disease. Weiss started studying ... She has studied the role of inflammasome-related cytokines in mouse hepatitis virus-induced disease. Despite murine coronavirus ... a paradigm of new emerging zoonotic diseases". Pathogens and Disease. 77 (9). doi:10.1093/femspd/ftaa006. ISSN 2049-632X. PMC ...
Newcastle Disease LaSota; Reticuloendotheliosis Virus; Salmonella pullorum-gallinarum ; Salmonella species; When by accident ... Avian Lymphoid Leukosis Virus; Lymphoid Leukosis Viruses A,B,C,D,E,J; Marek's Disease (Serotypes 1,2, 3); Mycoplasma ... Avian Nephritis Virus, Avian Paramyxovirus Type 2, Avian Reovirus S 1133, Avian Rhinotracheitis Virus; Avian Rotavirus; Avian ... Infectious Bursal Disease Type 1; Infectious Bursal Disease Type 2; Infectious Laryngotracheitis; Lymphoid Leukosis A, B; ...
NDV-HXP-S uses the Newcastle disease virus as its viral vector. The name NDV-HXP-S comes from the terms Newcastle disease virus ... 2020). "Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as vaccine candidate". Ebiomedicine. 62: ... The vaccine was developed using a modified virus, which causes the Newcastle disease in birds ... Cross R (20 July 2020). "What ... with groups from the Icahn School of Medicine at Mount Sinai and the National Institute of Allergy and Infectious Diseases ...
"Requirements for the Assembly and Release of Newcastle Disease Virus-Like Particles". Journal of Virology. 80 (22): 11062-11073 ... the cause of Newcastle disease (ND).[citation needed] Avian metaavulavirus 2 has been known to cause disease, specifically mild ... The virus was first isolated from a strain in Yucaipa, California in 1956. Since then, other isolates of the virus have been ... It is believed that the F and Hn proteins present on the outer envelope of the virus assist in entry of the virus into the host ...
"Effect of negative air ionization on airborne transmission of Newcastle disease virus". Avian Diseases. 38 (4): 725-32. doi: ... Airborne diseases can also affect non-humans. For example, Newcastle disease is an avian disease that affects many types of ... Airborne diseases include any that are caused via transmission through the air. Many airborne diseases are of great medical ... Socioeconomics has a minor role in airborne disease transmission. In cities, the spread of airborne disease is more rapid than ...
"Rescue of nonlytic Newcastle Disease Virus (NDV) expressing IL-15 for cancer immunotherapy". Virus Research. 233: 35-41. doi: ... Vector-based therapy - Nonlytic Newcastle Disease Virus (NDV) was engineered to express recombinant IL-15 protein to generate ... A recombinant vaccinia virus expressing influenza A proteins and IL-15 promoted cross protection by CD4+ T cells. A Brucella ... While influenza A virus expressing IL-15 stimulates both innate and adaptive immune cells to decrease tumor growth mice. ...
These new vaccines are using a harmless avian virus that causes Newcastle Disease. This vaccine has the benefit of being easy ... "Viruses Young Investigator in Virology Prize". Viruses. Retrieved 4 June 2020.. ... McLellan led a team from The University of Texas at Austin and the National Institute of Allergy and Infectious Diseases' ... Initial tests indicate that their antibody blocks viruses that display the SARS-CoV-2 spike protein from infecting cells in ...
The developed plant-made vaccine combats Newcastle Disease Virus "DowDuPont Merger Successfully Completed". corporate.dow.com. ... that it had received regulatory approval for the world's first plant-cell-produced vaccine against Newcastle disease virus from ...
CS1 maint: discouraged parameter (link) "USPTO - Recombinant newcastle disease virus RNA expression systems and vaccines". ... "Use of Reverse Genetics to Enhance the Oncolytic Properties of Newcastle Disease Virus". Cancer Research. 67 (17): 8285-8292. ... "Vaccination of Pigs against Swine Influenza Viruses by Using an NS1-Truncated Modified Live-Virus Vaccine". Journal of Virology ... "An enzymatic virus-like particle assay for sensitive detection of virus entry". Journal of Virological Methods. 163 (2): 336- ...
Bensink, Z. Spradbrow, P. B. (1999). "Newcastle disease virus strain I2 - a prospective thermostable vaccine for use in ... Controlling Newcastle Disease in Village Chickens: A Training Manual, 2002; 2nd Edition, 2003. Success story on the control of ... From July 2011 to May 2012, Alders was the Team Leader of a Newcastle disease control project in Angola implemented by the ... It was apparent that viral Newcastle disease (ND) was endemic and causing significant mortality and loss of production in these ...
The most notable avulavirus is the Newcastle disease virus, a strain of Avian orthoavulavirus 1. Like all Paramyxoviruses, ... "Virus Taxonomy: 2019 Release". talk.ictvonline.org. International Committee on Taxonomy of Viruses. Retrieved 7 May 2020. "AAB ... Avulavirinae is a subfamily of viruses in the family Paramyxoviridae. Members of the subfamily are collectively known as ... 6 June 2018). "Re-organization of the family Paramyxoviridae" (docx). International Committee on Taxonomy of Viruses. Retrieved ...
Fagbohun, O.A.; Oluwayelu, D.O.; Owoade, A.A.; Olayemi, F.O. (2000). "Survey for antibodies to Newcastle Disease virus in ... infectious bursal disease, and possibly Newcastle disease. This species has a large range, with an estimated global extent of ... Fagbohun, O.A.; Owoade, A.A.; Oluwayelu, D.O.; Olayemi, F.O. (2000). "Serological survey of infectious bursal disease virus ... This benefits both species, but it has been implicated in the spread of tick-borne animal diseases. The cattle egret was first ...
Fagbohun, O.A.; Oluwayelu, D.O.; Owoade, A.A.; Olayemi, F.O. (2000). "Survey for antibodies to Newcastle Disease virus in ... infectious bursal disease and possibly Newcastle disease. Linnaeus, C. (1758). Systema naturae per regna tria naturae, secundum ... Fagbohun, O.A.; Owoade, A.A.; Oluwayelu, D.O.; Olayemi, F.O. (2000). "Serological survey of infectious bursal disease virus ... This benefits both species, but it has been implicated in the spread of tick-borne animal diseases. The cattle egret was first ...
In 2012 he engineered new hypermutated strains of Newcastle Disease Virus, closely related to influenza virus. Data obtained ...
Her research on the Newcastle Disease Virus (NDV), a poultry virus has gained acknowledgement locally and globally.[citation ...
Roy, P., Venugopalan, A.T., Manvell, R. 1998 Isolation of Newcastle disease virus from an Indian house crow. Tropical animal ... such as PMV 1 that causes of Newcastle disease may be spread by Corvus splendens. Outbreaks of Newcastle disease in India were ... and their relation to disease. Calcutta: Government Press. p. 71. House Crow Monitor Bibliography from Corvids Literature ... health and production 30 (3):177-178 Blount, W.P. (1949). Diseases of Poultry. (London, Balliere, Tindall and Cox). S. ...
... and Newcastle disease viruses". The Journal of Experimental Medicine. 95 (1): 71-97. doi:10.1084/jem.95.1.71. PMC 2212053. PMID ... Another disease associated with mutations in this gene is Uromodulin-associated Kidney Disease (UKD), a rare autosomal dominant ... Medullary Cystic Kidney Disease 2 OMIM entries on UMOD-Related Kidney Disease Includes: Familial Juvenile Hyperuricemic ... Abbas AK, Gerber R, Mitchell RS, Kumar V, Fausto N (2006). Pocket companion to Robbins and Cotran Pathologic Basis of Disease ( ...
... and Newcastle disease viruses". J. Exp. Med. 95 (1): 71-97. doi:10.1084/jem.95.1.71. PMC 2212053. PMID 14907962. Who Was Who in ...
... mumps and Newcastle disease virus. Although viruses had been shown to infect animals in 1898, research on animal viruses was ... Hirst GK (1962). "Genetic recombination with Newcastle disease virus, polioviruses, and influenza". Cold Spring Harbor Symposia ... 1962) Genetic recombination with Newcastle disease virus, polioviruses, and influenza. Cold Spring Harbor Symposia on ... Human influenza virus had first been isolated just a few years earlier. Later, Hirst also studied other vertebrate RNA viruses ...
... measles viruses, rhabdoviruses, Newcastle disease virus, poxviruses, and picornaviruses. Most vaccines consist of viruses that ... The virus was injected into orange trees to combat citrus greening disease that had reduced orange production by 70% since 2005 ... Another potential use of genetically modified viruses is to alter them so they can directly treat diseases. This can be through ... To protect the Iberian species from viral diseases, the myxoma virus was genetically modified to immunize the rabbits, while in ...
... or pigeon paramyxovirus type 1 is a virus closely related to Newcastle disease which affects domestic pigeons and other ... the virus has predominantly infected introduced pigeons but one native species has been diagnosed with the disease - a collared ... inactivated Newcastle disease vaccine administered for protection against pigeon paramyxovirus-1". Australian Veterinary ... The virus then spread to Italy and North Africa, onwards across Europe and progressively throughout the rest of the world. ...
It is a vector for Avipoxvirus, Newcastle disease virus, Falconid herpesvirus 1 (and possibly other Herpesviridae), and some ... Raidal, S.; Jaensch, S. (2000). "Central nervous disease and blindness in Nankeen kestrels (Falco cenchroides) due to a novel ...
In 1951, he published a report for the Naval Medical Research Institute on Newcastle Disease virus in chicken and mammalian ... Erich Traub, "Studies on the In-Vitro Multiplication of Newcastle Disease Virus in Chicken Blood." Naval Medical Research ... Erich Traub, "Studies in the Mechanism of Immunity of Chickens to Newcastle Disease Virus." Naval Medical Research Institute, ... Capps on the foot-and-mouth disease virus and methods for rapid adaptation. Traub served as an expert on foot-and-mouth disease ...
... human parainfluenza virus 3, and the avian pathogen Newcastle disease virus. Types include: Mumps hemagglutinin-neuraminidase ... April 2004). "Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion ... Yuan P, Thompson TB, Wurzburg BA, Paterson RG, Lamb RA, Jardetzky TS (2005). "Structural studies of the parainfluenza virus 5 ... Hemagglutinin-neuraminidase allows the virus to stick to a potential host cell, and cut itself loose if necessary. ...
A number of viruses including adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus and vaccinia have now been ... An oncolytic virus is a virus that preferentially infects and kills cancer cells. As the infected cancer cells are destroyed by ... T-Vec is the first FDA-approved oncolytic virus for the treatment of melanoma. A number of other oncolytic viruses are in Phase ... have disease progression during or following platinum-containing chemotherapy. have disease progression within 12 months of ...
Avulavirus), mit Species Humanes Parainfluenzavirus, sowie Newcastle-Disease-Virus. *Genus Paraavulavirus. *Unterfamilie ... Usutu-Virus - en. Usutu virus (USUV), Zika-Virus - en. Zika virus (ZIKV), sowie Gelbfieber-Virus - en. Yellow fever virus (YFV) ... Genus ‚Negevirus', mit Species ‚Blackford virus', ‚Bofa virus', ‚Buckhurst virus', ‚Marsac virus', sowie ‚Muthill virus'[53] ... Sorghum mosaic virus (SrMV), Lily-Mottle-Virus - en. Lily mottle virus (LMoV), sowie Sellerie-Virus Y - en. Apium virus Y (ApVY ...
5 to 10-fold increase in rheumatic heart disease and hypertensive disease, 2-fold increase in other heart disease, 3-fold ... "Newcastle Herald.. *. Daley, Paul (15 July 2014). "Why the number of Indigenous deaths in the frontier wars matters". The ... 10-fold increase in tuberculosis, hepatitis B and hepatitis C virus, 20-fold increase in chlamydia, 40-fold increase in ... Circulatory system diseases account for 24% deaths[221]. Renal failure 2 to 3-fold 2 to 3-fold increase in listing on the ...
Diseases. *Aspergillosis. *Avian infectious laryngotracheitis. *Avian influenza. *Avian sarcoma leukosis virus. *Histomoniasis ... Infectious bursal disease. *Infectious coryza in chickens. *Marek's disease. *Mycoplasmas. *Newcastle disease ...
"Rescue of nonlytic Newcastle Disease Virus (NDV) expressing IL-15 for cancer immunotherapy". Virus Research. 233: 35-41. doi: ... Vector-based therapy - Nonlytic Newcastle Disease Virus (NDV) was engineered to express recombinant IL-15 protein to generate ... DiseaseEdit. Epstein-Barr virusEdit. In humans with history of acute infectious mononucleosis (the syndrome associated with ... Non-alcoholic fatty liver diseaseEdit. A recent report indicated IL-15 promotes non-alcoholic fatty liver disease.[26] ...
Centers for Disease Control (CDC) (1991). "Use of folic acid for prevention of spina bifida and other neural tube defects-1983- ... "Social History of Medicine - Uses of a Pandemic: Forging the Identities of Influenza and Virus Research in Interwar Britain". ... MRC Centre for Brain Ageing and Vitality (MRC CBAV) (based at Newcastle University) ... "Liver Study Offers Insights into Hard-to-treat Diseases" (Press release). University of Edinburgh. 9 March 2018. Retrieved 9 ...
Newcastle disease virus (NDV), is a variant of avian paramyxovirus 1 (APMV-1), a negative-sense, single-stranded RNA virus. NDV ... "Newcastle disease: Newcastle disease outbreaks in Great Britain". DEFRA.. *^ "California modifies virulent Newcastle disease ... Virulent Newcastle disease (VND), formerly exotic Newcastle disease,[1] is a contagious viral avian disease affecting many ... Wikimedia Commons has media related to Newcastle disease.. *Current status of Newcastle disease worldwide at OIE. WAHID ...
Diseases. *Aspergillosis. *Avian infectious laryngotracheitis. *Avian influenza. *Avian sarcoma leukosis virus. *Histomoniasis ... Infectious bursal disease. *Infectious coryza in chickens. *Marek's disease. *Mycoplasmas. *Newcastle disease ... Centers for Disease Control and Prevention *^ Crump JA, Luby SP, Mintz ED (May 2004). "The global burden of typhoid fever". ... "Centers for Disease Control and Prevention. U.S. Department of Health & Human Services. 25 November 2013. Retrieved 3 August ...
Paramyxoviridae (Newcastle disease, fåresyge og mæslinger). *Filoviridae (Ebola og Marburgfeber) [36]. Gruppe VI - ... Sygdomme forårsaget af virus[redigér , redigér wikikode]. Mange sygdomme forårsages af virus.[2][13][14] Nogle virus forårsager ... Samling af virus-komponenterne til komplette virus-partikler.. *Frigivelse af virus-partiklerne fra værtscellen for at inficere ... Revers transkriberende virus *DNA revers transkriberende virus. *RNA revers transkriberende virus Retrovirus *Familie: ...
Tommy Robson, 76, English footballer (Northampton Town, Newcastle United, Peterborough United), motor neurone disease.[451] ... Clark Middleton, 63, American actor (Sin City, Snowpiercer, Twin Peaks), West Nile virus.[535] ... Cecil Thiré, 77, Brazilian actor (The Guns, A Padroeira, Celebridade) and director, complications of Parkinson's disease.[426] ... Overton Berry [de], 84, American jazz pianist, heart disease.[177]. *George Henry Vanderbilt Cecil, 95, American businessman, ...
HIV/AIDS[8] and Ebola virus disease[9] are two examples of often-lethal infectious disease epidemics whose medical care and ... The powder is used by witches to curse their victims.[156] The effect of the áńt'į́ is a curse and disease, usually indicated ... "Ebola: Human Rights Group Warns Disease Is Not Caused By Witchcraft". 3 September 2014. Archived from the original on 3 ... Lancashire abounds with witch-doctors, a set of quacks, who pretend to cure diseases inflicted by the devil ... The witch- ...
Infectious bronchitis virus Infectious bursal disease Gumboro infectious bursal disease virus Infectious coryza in chickens ... Newcastle disease Avian avulavirus 1 Necrotic enteritis bacteria Omphalitis Mushy chick disease[103] bacteria ... Diseases and ailments. See also: Poultry disease. Chickens are susceptible to several parasites, including lice, mites, ticks, ... "Centers for Disease Control and Prevention. Retrieved 2019-04-03.. *^ "Overview of Omphalitis in Poultry". Merck Veterinary ...
a b c d e Human infection with avian influenza A(H7N9) virus - China, WHO, Disease outbreak news, 17 January 2017. ... while similar diseases such as Newcastle disease, acute fowl cholera, infectious laryngotracheitis, and infectious bursal ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... Further information: Influenza A virus subtype H7N9. Influenza A virus subtype H7N9 is a novel avian influenza virus first ...
Infectious bursal disease. *Infectious coryza in chickens. *Marek's disease. *Mycoplasmas. *Newcastle disease ... Diseases. *Aspergillosis. *Avian influenza. *Avian sarcoma leukosis virus. *Histomoniasis (blackhead disease). *Botulism ...
It also appeared in Gateshead and Newcastle. In London, the disease claimed 6,536 victims; in Paris, 20,000 died (out of a ... Kerala Nipah virus (2018). *Équateur province Ebola (2018). *Kivu Ebola (2018-2020) ... From there, the disease spread along trade routes to cover most of India. By 1828, the disease had traveled to China. Cholera ... Charlotte E. Henze (15 December 2010). Disease, Health Care and Government in Late Imperial Russia: Life and Death on the Volga ...
It has also been shown to be effective in removing exotic animal viruses, such as avian influenza and Newcastle disease from ... Centers for Disease Control and Prevention (21 December 2012). "Sterilization or Disinfection of Medical Devices". CDC. ... "U.S. Centers for Disease Control and Prevention. Archived from the original on 13 April 2016. Retrieved 19 April 2016.. .mw- ... In the 1940s and early 1950s, further studies showed inactivation of diverse bacteria, influenza virus, and Penicillium ...
"Migratory birds and spread of West Nile virus in the Western Hemisphere". Emerging Infectious Diseases. 6 (4): 319-328. doi ... Bewick, Thomas (1797-1804). History of British Birds (1847 ed.). Newcastle: Beilby and Bewick.. ... Some viruses that are maintained in birds without lethal effects, such as the West Nile Virus may however be spread by ... Due to the global spread of avian influenza, bird migration has been studied as a possible mechanism of disease transmission, ...
Levels of bacteria and viruses in swimming pool water must be kept low to prevent the spread of diseases and pathogens. ... 100 m baths in Newcastle. While most are free, a number charge fees, such as the Bondi Icebergs Club pool at Bondi Beach. ...
Parkinson's disease and Alzheimer's disease.[70] The Human Fertilisation and Embryology Act 2008, a major review of fertility ... If a virus is used as a reprogramming factor for the cell, cancer-causing genes called oncogenes may be activated. These cells ... The first license was granted on August 11, 2004 to researchers at the University of Newcastle to allow them to investigate ... Research is underway to potentially use stem cell therapy to treat heart disease, diabetes, and spinal cord injuries.[29][30] ...
Infectious bursal disease. *Infectious coryza in chickens. *Marek's disease. *Mycoplasmas. *Newcastle disease ... Diseases. *Aspergillosis. *Avian influenza. *Avian sarcoma leukosis virus. *Histomoniasis (blackhead disease). *Botulism ... "Diseases of the Uropygial Gland". Exoticpetvet.net. Retrieved 2011-12-20.. *^ Keeling, L.J., 1995. Feather pecking and ... of the prevalence of feather pecking in laying hens in alternative systems and its association with management and disease. ...
"Survey for antibodies to Newcastle Disease virus in cattle egrets, pigeons and Nigerian laughing doves" (PDF). African Journal ... and possibly Newcastle disease.[53][54]. References[edit]. *^ Linnaeus, C. (1758). Systema naturae per regna tria naturae, ... "Serological survey of infectious bursal disease virus antibodies in cattle egrets, pigeons and Nigerian laughing doves". ... This benefits both species, but it has been implicated in the spread of tick-borne animal diseases. ...
"WHO Coronavirus Disease (COVID-19) Dashboard". World Health Organization. Retrieved 18 July 2020. "Virus korona COVID 19" (in ... both members of a family of Chinese nationals staying in a hotel in York who were taken to specialist facilities in Newcastle ... Szumowski: the virus will arrive in the coming days]. Gazeta Wyborcza (in Polish). 27 February 2020. Archived from the original ... For patients tested positive for the virus a 21-day house quarantine was introduced. This time span is counted from the day a ...
Deformed wing virus has been found to affect 11% of bumblebees in Great Britain. Female bee moths (Aphomia sociella) prefer to ... University of Newcastle-upon-Tyne (28 July 2006). "Scientists map the flight of the bumblebee". Science Daily. Harman, Alan ( ... The workers remove dead bees or larvae from the nest and deposit them outside the nest entrance, helping to prevent disease. ... The queens were checked for mites and American foulbrood disease. Agri-environment schemes spread across the neighbouring area ...
... sendai virus, and persistent newcastle disease virus. Youngner is responsible for the first equine influenza vaccine, based ... Role in Maintenance of Persistent Newcastle Disease Virus Infections of L Cells". Journal of Virology. 12 (3): 481-491. doi: ... "Temperature-Sensitive Defect of Mutants Isolated from L Cells Persistently Infected with Newcastle Disease Virus". Journal of ... "Temperature-Sensitive Mutants Isolated from L Cells Persistently Infected with Newcastle Disease Virus". Journal of Virology. 9 ...
In poultry, In ovo vaccination improves hatchability and efficient protection against Avian influenza (AI), Newcastle disease ( ... In medical usage it refers to the growth of live virus in chicken egg embryos for vaccine development for human use, as well as ... In ovo vaccination of chicken embryos with experimental Newcastle disease and avian influenza oil-emulsion vaccines. Avian Dis ... The birds are protected before delivery to a commercial operation such as a farm, thus preventing the spread of Avian viruses. ...
They include defining the nature of Newcastle virus and the observation of "incomplete" viral particles usable for use in ... Clinical Infectious Diseases. 46 (8): 1327. doi:10.1086/533446. ISSN 1058-4838. "Abe Eisenstark".. ... a bacterial virus that has been important for understanding gene transposition and the development of molecular genetics At the ...
Tommy Robson, 76, English footballer (Northampton Town, Newcastle United, Peterborough United), motor neurone disease. Mohammad ... Clark Middleton, 63, American actor (Sin City, Snowpiercer, Twin Peaks), West Nile virus. Carla Federica Nespolo, 77, Italian ... Cecil Thiré, 77, Brazilian actor (The Guns, A Padroeira, Celebridade) and director, complications of Parkinson's disease. Vijay ... Jesse Arnelle, 86, American basketball player (Fort Wayne Pistons) and lawyer, heart disease. Gordon Astall, 93, English ...
Winner of the 1984 Hugo Award for Best Short Story, "Speech Sounds" explores a universe where a virus has eradicated speech. ... Newcastle upon Tyne, England: Cambridge Scholars, 2015. 82-94. ISBN 978-1443872027 Troy, Maria Holmgren. "Loss of Words: ... The incredible violence caused by DGD patients experiencing drift has caused people with this disease to be shunned by society ... The Evening and the Morning and the Night explores a world where a genetic disease has caused the appearance of a new social ...
Researchers have found that a recombinant Newcastle disease virus kills all kinds of prostate cancer cells, including hormone ... Newcastle disease virus shows promise as safe prostate cancer treatment. Newcastle disease virus shows promise as safe prostate ... Newcastle disease virus kills chickens, but does not harm humans. It is an oncolytic virus that hones in on tumors, and has ... Retargeted Newcastle disease virus has major potential advantages over other cancer therapies, said Elankumaran. ...
Effects of Newcastle Disease Virus on Human Cancer Cells. The ability of Newcastle disease virus (NDV) to replicate efficiently ... rabies virus. Over the next 60 years, many other viruses, including Newcastle disease virus (NDV), were shown to have ... Newcastle disease virus pathotypes. Avian Pathol 3 (4): 269-78, 1974.. *Hanson RP: The reemergence of Newcastle disease. Adv ... Newcastle disease virus-induced cytopathic effect in infected cells is caused by apoptosis. Virus Res 141 (1): 13-20, 2009. ...
... some naturally occurring viruses display unmatched oncolytic activity. Newcastle disease virus (NDV) excels as an oncolytic ... Newcastle disease virus (NDV): brief history of its oncolytic strains.. Sinkovics JG1, Horvath JC. ... While genetically engineered viruses are now being tested for the virus therapy of human cancers, ... Newcastle disease virus/genetics. *Newcastle disease virus/immunology. *Newcastle disease virus/pathogenicity ...
... is a virus that replicates more quickly in human cancer cells than in normal human cells and can kill these host cells. NDV can ... What Are the Results of Newcastle Disease Virus Human Studies?. *What Are the Side Effects or Risks from Newcastle Disease ... Newcastle disease virus (NDV) is a virus that causes a deadly infection in many kinds of birds. In humans, NDV causes mild flu- ... Newcastle disease virus (NDV) is a virus that is of interest because it replicates (makes copies of itself) more quickly in ...
1 Abstracts with Newcastle Disease Virus Research. Filter by Study Type. Viral. ... 1 Diseases Researched for Newcastle Disease Virus Name. AC. CK. Focus. Newcastle Disease Virus. 1. 1. ... or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional ... Diseases : Newcastle Disease Virus. Pharmacological Actions : Antiviral Agents. Problem Substances : Newcastle Disease Virus ...
Virulent Newcastle disease virus elicits a strong innate immune response in chickens.. Rue CA1, Susta L, Cornax I, Brown CC, ... Newcastle disease virus (NDV) is an avian paramyxovirus that causes significant economic losses to the poultry industry ... Newcastle Disease/pathology. *Newcastle Disease/virology. *Newcastle disease virus/immunology*. *Newcastle disease virus/ ... and how this response may contribute to disease. In this study, pathogenesis and the transcriptional host response of chickens ...
... Egbal Sidahmed Abdelrahim and Jedda Elhag ... Egbal Sidahmed Abdelrahim and Jedda Elhag, "A Case of Newcastle Disease Virus in Red-Headed Lovebird in Sudan," Case Reports in ...
Taxonomy - Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) Basket 0 ... Newcastle disease virus B1/48. ›Newcastle disease virus (strain B1/48). Rank i. - ... Viruses. › Riboviria. › Negarnaviricota. › Haploviricotina. › Monjiviricetes. › Mononegavirales. › Paramyxoviridae. › ...
A POULTRY farm whose entire livestock was destroyed after an outbreak of the Newcastle Virus (NDV) has warned that it could be ... By Maria Gregoriou AUTHORITIES have said there have been no new reported incidents of the contagious Newcastle disease after ... No recurrence of poultry virus say vet services. Maria Gregoriou. August 21, 2013. October 14, 2013. ...
Re: Newcastle Disease Virus (NDV) in poultry [Re: Marty] #312819 11/29/08 01:18 PM 11/29/08 01:18 PM ... Re: Newcastle Disease Virus (NDV) in poultry [Re: shuffles] #312827 11/29/08 02:11 PM 11/29/08 02:11 PM ... Register Log In AmbergrisCaye.com Home Forums Living in Belize Newcastle Disease Virus (NDV) in poultry ... Newcastle Disease Virus (NDV) in poultry #312815 11/29/08 12:50 PM 11/29/08 12:50 PM ...
The Philippines Chief Veterinary Officer has said that Newcastle disease has been spreading into more areas in the Philippines ... PHILIPPINES - The Philippines Chief Veterinary Officer has said that Newcastle disease has been spreading into more areas in ... Local media reports suggest that some poultry farmers have had to cease operations to cut their losses from Newcastle disease. ... An increase in poultry mortalities from the disease has been observed since typhoon Nona hit the Philippines in December 2015. ...
... is an intrinsically tumor-specific virus, which is currently under investigation as a clinical oncolytic agent. Several ... Newcastle disease virus (NDV) is an intrinsically tumor-specific virus, which is currently under investigation as a clinical ... Engineered newcastle disease virus as an improved oncolytic agent against hepatocellular carcinoma Mol Ther. 2010 Feb;18(2):275 ... The endogenous NDV fusion (F) protein directs membrane fusion, which is required for virus entry and cell-cell fusion. Here, we ...
Newcastle disease virus (NDV) is an important pathogen that causes disease and death not only in domestic and commercial ... Newcastle Disease Virus Vaccine on the Horizon. Health & disease Treatments and prevention Poultry health ... Current Newcastle disease (ND) vaccines are used widely in commercial poultry and protect the vaccinated birds from disease but ... Microbiologist Qingzhong Yu examines recombinant Newcastle disease virus vaccine candidates in infected cells ...
Newcastle disease virus (NDV) is an important pathogen that causes disease and death not only in domestic and commercial ... Current Newcastle disease (ND) vaccines are used widely in commercial poultry and protect the vaccinated birds from disease but ... Microbiologist Qingzhong Yu examines recombinant Newcastle disease virus vaccine candidates in infected cells ... research is aimed at developing a vaccine against Newcastle disease that reduces virulent virus shed and transmission - ...
Several strains of the Newcastle disease virus (NDV) have been used as oncolytics in vitro and in a number of in vivo ... Research on oncolytic viruses has mostly been directed towards the treatment of solid tumors, which has yielded limited ... Keywords: Newcastle disease virus; lymphoma; oncolytic virus Newcastle disease virus; lymphoma; oncolytic virus ... "Newcastle Disease Virus: Potential Therapeutic Application for Human and Canine Lymphoma." Viruses 8, no. 1: 3. ...
Journal of Wildlife Diseases publishes work on infectious, parasitic, toxic, nutritional, physiologic, and neoplastic diseases ... Characterization of Pigeon-Origin Newcastle Disease Virus Isolated in China Characterization of Newcastle Disease Virus ... CHARACTERIZATION OF VELOGENIC NEWCASTLE DISEASE VIRUSES ISOLATED FROM DEAD WILD BIRDS IN SERBIA DURING 2007. ... Avian paramyxoviruses type 1 or Newcastle disease viruses (NDV) are frequently recovered from wild birds and such isolates are ...
R. A. Saeed, Cytolytic Effects of Newcastle Disease Virus Strain AF2240 on DBTRG . 05MG AND U-87MG Brain Tumot Cell Lines, ... M. Mahadi, Cellular apoptosis of 4T1 breast cncer cells induced by V4-UPM newcastle disease virus [M.S. thesis], Universiti ... Newcastle disease virus (NDV) is one of such oncolytic viruses that replicate and kill cancer cells while sparing normal cells ... N. Meyyapan, Oncolytic Effect of Newcastle Disease Virus on the MCF-7 and MDA-MB-231 Breast Cancer Cell Lines, Universiti Putra ...
Local Immunologic Response to Immunization with Inactivated Newcastle Disease Virus. Zichriya Zakay-Rones, R. Levy and G. Spira ... Local Immunologic Response to Immunization with Inactivated Newcastle Disease Virus Message Subject (Your Name) has forwarded a ... Chickens were immunized with Newcastle disease virus inactivated by β propriolactone. The antigen was administered by the ... Seoul virus alters proinflammatory and antiviral responses of macrophages from Norway rats (45.14) ...
... while transfer of these three genes in combination significantly affected the chimeric virus virulence, especially when the L ... while transfer of these three genes in combination significantly affected the chimeric virus virulence, especially when the L ... The virulence of Newcastle disease virus varies greatly and is determined by multiple genetic factors. In this study, we ... The virulence of Newcastle disease virus varies greatly and is determined by multiple genetic factors. In this study, we ...
Newcastle disease virus (NDV) envelope glycoproteins that are expressed at the surface of fixed NDV (Ploufragan strain)- ... Interferon-induction in mouse spleen cells by the Newcastle disease virus (NDV) HN protein Ann Rech Vet. 1991;22(4):365-72. ... Newcastle disease virus (NDV) envelope glycoproteins that are expressed at the surface of fixed NDV (Ploufragan strain)- ...
Newcastle disease virus (NDV) is a single-stranded negative-sense RNA virus that belongs to the genus Avulavirus of the family ... Genomic sequence of an antigenic variant Newcastle disease virus isolated in Korea. Virus Genes. doi:10.1007/s11262-007-0078-z. ... Newcastle disease virus isolated from recent outbreaks in Taiwan phylogenetically related to viruses (genotype VII) from recent ... Variation of a Newcastle Disease Virus Hemagglutinin-Neuraminidase Linear Epitope. Sun-Hee Cho, Hyuk-Joon Kwon, Tae-Eun Kim, ...
Proteins of the Newcastle Disease Virus Membrane I. M. CHEYNE; I. M. CHEYNE ... I. M. CHEYNE, D. C. BURKE; Proteins of the Newcastle Disease Virus Membrane. Biochem Soc Trans 1 August 1974; 2 (4): 735-737. ... Mapping the membrane proteins of Newcastle-disease virus with a photoreactive glycolipid probe Biochem J (February, 1979) ... 8th UK-NL Nitrogen Cycle Meeting; Newcastle upon Tyne, UK: 29 August-1 September 2002 Biochem (Lond) (December, 2002) ...
Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging ... Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging ... Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging ... Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging ...
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Recombinant Newcastle disease virus (rNDV), a non-segmented negative-sense RNA virus (NSNSV), was first rescued in 1999 using a ... Rescue of recombinant Newcastle disease virus : a short history of how it all started. Molouki, Aidin; Peeters, Ben ... Reverse genetics of viruses has come a long way, and many recombinant viruses have been generated since the first successful " ... because it allows one to make the best choices for fulfilling the specific requirements of the final recombinant virus. We have ...
Genotype Diversity of Newcastle Disease Virus in Nigeria : Disease Control Challenges and Future Outlook. Bello, Muhammad ... The aetiology of the disease is an avian paramyxovirus type-1 or Newcastle disease virus (NDV), whose isolates are ... Newcastle disease (ND) is one of the most important avian diseases with considerable threat to the productivity of poultry all ... The disease is associated with severe respiratory, gastrointestinal, and neurological lesions in chicken leading to high ...
Newcastle disease virus (NDV) is a naturally oncolytic virus that has been shown to be safe and effective for cancer therapy. ... Construction of recombinant Newcastle disease virus Italien strain for oncolytic virotherapy of tumors. ... protein cleavage site - hepatitis-c virus - fusion protein - cancer-therapy - vaccine vector - foreign gene - phase-i - pv701 ... We evaluated the replication and antitumor characteristics of these viruses in vitro and in vivo. Our data showed that the ...
1988) Newcastle disease, Newcastle disease virus-an avian paramyxovirus (Kluwer Academic Publishers, Dordrecht, The Netherlands ... Recombinant Newcastle Disease Virus as a Vaccine Vector. Takaaki Nakaya, Jerome Cros, Man-Seong Park, Yurie Nakaya, Hongyong ... Recombinant Newcastle Disease Virus as a Vaccine Vector. Takaaki Nakaya, Jerome Cros, Man-Seong Park, Yurie Nakaya, Hongyong ... Recombinant Newcastle Disease Virus as a Vaccine Vector. Takaaki Nakaya, Jerome Cros, Man-Seong Park, Yurie Nakaya, Hongyong ...
Recombinant Newcastle Disease Virus as a Vaccine Vector. Takaaki Nakaya, Jerome Cros, Man-Seong Park, Yurie Nakaya, Hongyong ... Recombinant Newcastle Disease Virus as a Vaccine Vector. Takaaki Nakaya, Jerome Cros, Man-Seong Park, Yurie Nakaya, Hongyong ... Recombinant Newcastle Disease Virus as a Vaccine Vector. Takaaki Nakaya, Jerome Cros, Man-Seong Park, Yurie Nakaya, Hongyong ... Recombinant Newcastle Disease Virus as a Vaccine Vector Message Subject (Your Name) has forwarded a page to you from Journal of ...
... specific metastatic cancers who failed prior therapeutic regimes will be treated with NDV for at least a year or until disease ... Clinical Application of Intravenous New Castle Disease Virus - HUJ Oncolytic Virus in the Treatment of Advanced Glioblastoma ... Clinical Application of Intravenous New Castle Disease Virus - HUJ Oncolytic Virus in the Treatment of Advanced Glioblastoma ... New Castle Virus (NDV). has a long history as a broad system oncolytic that can destroy tumor cells and stimulate. the immune ...
  • Newcastle disease virus kills chickens, but does not harm humans. (sify.com)
  • NDV is a paramyxovirus that causes Newcastle disease in a wide variety of birds (most notably, in chickens). (oncolink.org)
  • Virulent Newcastle disease virus elicits a strong innate immune response in chickens. (nih.gov)
  • By Maria Gregoriou AUTHORITIES have said there have been no new reported incidents of the contagious Newcastle disease after some 190,000 chickens were culled between. (cyprus-mail.com)
  • The most severe form of ND can result in disease and mortality rates exceeding 90 per cent in susceptible chickens. (thepoultrysite.com)
  • Chickens were immunized with Newcastle disease virus inactivated by β propriolactone. (jimmunol.org)
  • As culling is the preferred control strategy in the developed world, and as the epidemiology of vNDV in countries where the virus is endemic is not well understood, evidence supporting a role of vaccinated chickens as a reservoir is missing. (asm.org)
  • The hematological lesions consequent upon velogenic Newcastle disease virus (NDV) infection were investigated in 6-week-old ducks and chickens. (scirp.org)
  • The severity of this virus infection in chickens and the mild clinical signs and lesions presented by ducks showed that ducks are far less susceptible than chickens. (scirp.org)
  • Igwe, A.O., Ezema, W.S., Ibu, J.I., Eze, J.I. and Okoye, J.O.A. (2013) Comparative Study of the Haematology and Persistence of Velogenic Newcastle Diseases in Chickens and Guinea Fowls. (scirp.org)
  • Complete deletions of 5' HN UTR down regulated its transcription, translation levels and incorporation of HN protein into virus particle, therefore, attenuated the pathogenicity of NDV in chickens. (umd.edu)
  • This product is used for the detection of Newcastle disease antibodies in chicken serum and egg yolk, to determine whether the chickens were seized infected with Newcastle disease virus or immune chicken antibody levels in the body. (krishgen.com)
  • A Recombinant Newcastle Disease Virus (NDV) Expressing S Protein of Infectious Bronchitis Virus (IBV) Protects Chickens against IBV and NDV. (bioportfolio.com)
  • Infectious bronchitis virus (IBV) causes a highly contagious respiratory, reproductive and urogenital tract disease in chickens worldwide, resulting in substantial economic losses for the poultry indu. (bioportfolio.com)
  • Recombinant infectious laryngotracheitis virus expressing Newcastle disease virus F protein protects chickens against infectious laryngotracheitis virus and Newcastle disease virus challenge. (bioportfolio.com)
  • In this study, we isolated and identified an infectious laryngotracheitis virus (ILTV) that was naturally avirulent in specific pathogen-free (SPF) chickens, with the aim of developing a more efficaci. (bioportfolio.com)
  • A novel recombinant attenuated Newcastle disease virus expressing H9 subtype hemagglutinin protected chickens from challenge by genotype VII virulent Newcastle disease virus and H9N2 avian influenza virus. (bioportfolio.com)
  • Active surveillance conducted for Newcastle disease indicates no scientific evidence of virulent NDV infection in chickens in Jeju Province, Korea since 2005. (koreamed.org)
  • Vaccination with these ND vaccines protected chickens from clinical disease. (scielo.br)
  • However, vaccinated chickens shed the challenge virus in fecal samples. (scielo.br)
  • In conclusion, the currently used vaccines with different vaccination schemes can protect chickens against the disease in areas where ND is endemic, while the spread of the field virus to other flocks cannot be prevented. (scielo.br)
  • NDV isolates are classified as lentogenic (low), mesogenic (intermediate), or velogenic (highly virulent), depending on the severity of the disease produced by the isolate in chickens ( Alexander, 1997 ). (scielo.br)
  • Importantly, in vaccinated chickens, virus shedding was abolished, providing an added advantage over the currently available commercial live-attenuated and inactivated vaccines, which are unable to prevent shedding. (lancs.ac.uk)
  • In an effort to protect chickens against Newcastle disease (ND), a nonreplicating virosome vaccine was produced by solubilization of Newcastle disease virus (NDV) with Triton X-100 followed by detergent removal with SM2 Bio-Beads. (semanticscholar.org)
  • Protection of chickens against overt clinical disease and determination of viral shedding following vaccination with commercially available Newcastle disease virus vaccines upon challenge with highly virulent virus from the California 2002 exotic Newcastle disease outbreak. (semanticscholar.org)
  • Here, we generated transgenic chickens using avian sarcoma-leukosis virus (RCAS)-based gene transfer system that constitutively and stably express chIFIT5. (figshare.com)
  • for vNDV), a delayed and lower level of clinical disease and mortality, reduced virus shedding and tissue damage was observed compared to non-transgenic control chickens. (figshare.com)
  • These findings propose the potential of innate immune genes in conferring genetic resistance in chickens against highly pathogenic and zoonotic viral pathogens causing sever disease in both animals and humans. (figshare.com)
  • The virus of Newcastle disease of chickens resembles those of the encephalitis group in its ability to spread throughout the developing egg and embryo, but it is similar to influenza virus in the high concentration of it found in the allantoic fluid before death. (rupress.org)
  • Chickens and ducks are major hosts of Newcastle disease virus (NDV) with distinct responses to infection. (biomedcentral.com)
  • However, whereas ducks are generally asymptomatic or exhibit only mild symptoms following NDV infection and are thus regarded as potential long-term reservoirs of the virus, chickens exhibit severe clinical lesions, transient infections and even death due to NDV infection. (biomedcentral.com)
  • However, the information about genetic characteristics of the Newcastle disease viruses (NDVs) circulating in commercial chickens and wild birds is scarce. (springeropen.com)
  • Phylogenic analysis of the partial cleavage site of F-gene (260 bp) indicated that all the sequences of viruses obtained from pigeons were identical and clustered within the genotype VIh while the sequences of viruses obtained from chickens were clustered together within the genotype VIf. (springeropen.com)
  • In vivo trials are needed to validate the use of resin from the tree in controlling Newcastle disease in chickens. (altmetric.com)
  • Exotic Newcastle Disease Virus (ENDV) cause extremely rapid mortality in chickens after exposure to the virus. (iastate.edu)
  • Newcastle disease virus (NDV) is a virus that kills chickens (it is an "avian paramyxovirus") but is harmless to humans. (medicalnewstoday.com)
  • Virulent Newcastle disease virus infection can cause 100% morbidity and mortality in chickens. (usda.gov)
  • Previously, we demonstrated that a duck enteritis virus (DEV) vaccine strain is a promising vector to generate recombinant vaccines in chickens. (usda.gov)
  • Newcastle disease virus (NDV) is an avian paramyxovirus that causes significant economic losses to the poultry industry worldwide. (nih.gov)
  • A POULTRY farm whose entire livestock was destroyed after an outbreak of the Newcastle Virus (NDV) has warned that it could be forced to shut. (cyprus-mail.com)
  • An increase in poultry mortalities from the disease has been observed since typhoon Nona hit the Philippines in December 2015. (thepoultrysite.com)
  • Local media reports suggest that some poultry farmers have had to cease operations to cut their losses from Newcastle disease. (thepoultrysite.com)
  • USDA Agricultural Research Service (ARS) research is aimed at developing a vaccine against Newcastle disease that reduces virulent virus shed and transmission - characteristics much needed by the poultry industry. (thepoultrysite.com)
  • Newcastle disease virus (NDV) is an important pathogen that causes disease and death not only in domestic and commercial poultry, but also in wild bird populations around the world. (thepoultrysite.com)
  • Current Newcastle disease (ND) vaccines are used widely in commercial poultry and protect the vaccinated birds from disease but do not prevent them from becoming infected and carrying the virulent virus or shedding it in their faeces. (thepoultrysite.com)
  • A vaccine that reduces virulent virus shed and transmission is sorely needed by the poultry industry. (thepoultrysite.com)
  • Using reverse genetics technology, researchers in the Endemic Poultry Viral Disease Research Unit and the Exotic and Emerging Viral Diseases Research Unit of the Southeast Poultry Research Laboratory in Athens, Georgia, have developed a new vaccine from parts of a virus that is similar to the wild-type NDV circulating in the environment today. (thepoultrysite.com)
  • This new vaccine not only reduces mortality and severity of ND symptoms in poultry, but it also decreases the amount of virulent virus shed from vaccinated birds. (thepoultrysite.com)
  • Newcastle disease continues to be a danger to the commercial poultry industry because it can spread rapidly and can exact a heavy toll," says Dr Yu. (thepoultrysite.com)
  • Phylogenetic analysis based on a partial F gene sequence showed that the isolates from wild birds cluster together with concurrent isolates from poultry in Serbia within the subgenotype VIId, which is the predominant pathogen involved currently in Newcastle disease outbreaks in poultry worldwide. (bioone.org)
  • It is unlikely that the wild birds played an important role in primary introduction or consequent spread of the velogenic NDV to domestic poultry in Serbia, and they probably contracted the virus from locally infected poultry. (bioone.org)
  • The virus causes a highly contagious disease affecting brain and gastrointestinal and respiratory tracts of a poultry species [ 7 ]. (hindawi.com)
  • Newcastle disease (ND) is a severe infectious disease of poultry caused by the Newcastle disease virus (NDV) that affects more than 250 species of birds. (frontiersin.org)
  • Newcastle disease (ND) is one of the most important avian diseases with considerable threat to the productivity of poultry all over the world. (wur.nl)
  • Newcastle disease (ND) is one of the most devastating diseases affecting the poultry industry worldwide ( 1 ). (asm.org)
  • however, those species normally carry viruses of genotypes Va and VI ( 1 ), and the reservoir for other highly virulent viruses that commonly circulate in poultry (genotypes Vb, VII, and XII to XVIII) is unknown. (asm.org)
  • thus, circumstantial evidence suggests that the capacity of vaccinated birds to shed the viruses may allow vaccinated poultry to act as a reservoir ( 1 ). (asm.org)
  • Given the different methods of poultry production in different countries and the presence of wild birds and their natural behaviour and migratory routes, it remains difficult to eradicate Newcastle disease and bring down its currently high rates of occurrence, as it is still endemic in most countries in Asia, the Middle East, Africa, Central America and South America. (thepoultrysite.com)
  • Newcastle disease is a highly contagious viral disease of poultry and wild birds, capable of causing up to 100% mortality. (scienceimage.csiro.au)
  • To expand the epidemiological understanding of Newcastle disease in Jeju Province, Korea, active surveillance was extensively performed through a virological examination for poultry farms and wild birds in Jeju Province during 2007~2008. (koreamed.org)
  • Despite the intensive vaccination programs used for controlling Newcastle disease (ND) in the Iranian poultry industry, outbreaks of ND have been reported in poultry farms. (scielo.br)
  • This represents a major problem for the poultry industry and therefore, further investigation on vaccines and vaccination programs to prevent and control this disease more appropriately is required. (scielo.br)
  • Newcastle disease virus (NDV) has devastating impacts on poultry throughout the world. (iastate.edu)
  • Newcastle disease virus (NDV), an avian paramyxovirus, is the causative agent of an economically important and highly contagious disease of poultry. (asm.org)
  • Dundon, William 2017-05-03 00:00:00 The complete sequences of the fusion (F) protein genes of six Newcastle disease virus (NDV) isolates from backyard poultry in Namibia in 2016 have been determined. (deepdyve.com)
  • Newcastle disease (ND) is one of the most contagious and devastating diseases to poultry in the world. (biomedcentral.com)
  • Aim: Newcastle disease is still one of the major threats for poultry industry allover the world. (scopemed.org)
  • Newcastle disease (ND) is a highly contagious disease of many avian species and is particularly responsible for devastating disease outbreaks in commercial poultry flocks in Pakistan that incur huge economic losses to the national poultry industry annually. (lancs.ac.uk)
  • Despite implementation of an extensive vaccination program for poultry birds, the disease appears in an endemic form in commercial broiler and layer poultry farms. (lancs.ac.uk)
  • This study was conducted to identify the prevalent velogenic NDV strain responsible for disease outbreaks in commercial poultry farms in Punjab, Pakistan. (lancs.ac.uk)
  • These requirements have been implemented in order to conform with international ND vaccine safety assessment standards, which employ a standardized ICPI testing protocol to characterize the residual virulence of master seed viruses for modified live ND vaccines for use in poultry. (gc.ca)
  • A virulent NDV from a cloacal swab collected from a chicken at a live bird market in the Mbeya region of Tanzania in 2012 was isolated at the Southeast Poultry Research Laboratory of the USDA in Athens, GA. The virus was propagated in 9-day-old specific-pathogen-free embryonating chicken eggs, and the intracerebral pathogenicity index (ICPI) was estimated following standard procedures ( 6 ). (asm.org)
  • Online Resource 5 Complete genome relative synonymous codon usage (RSCU) values among poultry and wild bird viruses. (up.ac.za)
  • Newcastle disease virus (NDV) has a wide avian host range and a high degree of genetic variability, and virulent strains cause Newcastle disease (ND), a worldwide concern for poultry health. (up.ac.za)
  • Although NDV has been studied in Nigeria, genetic information about the viruses involved in the endemicity of the disease and the transmission that likely occurs at the poultry-wildlife interface is still largely incomplete. (up.ac.za)
  • The similarities between viruses from poultry and multiple bird species and the lack of evidence for host adaptation in codon usage suggest that transmission of NDV between poultry and non-poultry birds occurred recently. (up.ac.za)
  • Caused by Newcastle disease virus (NDV), Newcastle disease (ND) is one of the most critical diseases in poultry and wild birds, largely due to its high morbidity and mortality, as well as its worldwide distribution and threat of considerable economic losses to avian industries [ 1 ]. (biomedcentral.com)
  • Newcastle disease virus (NDV) is a threat to the global poultry industry, but particularly for smallholder farmers in low- and middle-income countries. (elsevier.com)
  • Newcastle disease (ND), caused by virulent avian paramyxovirus type 1, is one of the most important diseases responsible for devastating outbreaks in poultry flocks in Ethiopia. (springeropen.com)
  • Newcastle disease (ND) is a highly contagious and devastating disease of poultry caused by the Newcastle disease virus (NDV) also known as avian paramyxovirus type 1, (APMV-1). (springeropen.com)
  • Class II contains viruses that have been isolated from multiple wild birds and poultry species. (springeropen.com)
  • Most viruses within this group are virulent and cause significant economic losses to poultry industry worldwide (Miller et al. (springeropen.com)
  • Wild birds seem to be the reservoir of avirulent strains, whereas poultry are the most important host of the virulent viruses but both hosts exchange viruses (Cardenas et al. (springeropen.com)
  • Newcastle disease, caused by NDV, is one of the most important diseases of poultry around the globe. (pirbright.ac.uk)
  • Forty-four Newcastle disease virus (NDV) strains, obtained between 2002 and 2007 from different poultry species in Nigeria, Niger, Burkina Faso and Cameroon, were phylogenetically analysed based on partial F sequences. (mysciencework.com)
  • Newcastle disease virus (NDV) is a major threat to poultry worldwide. (usda.gov)
  • Echeonwu, G.O.N., Ireogbu, C.U. and Emeruwa, A.C. (1993) Recovery of Velogenic Newcastle Disease Virus from Dead and Healthy Free Roaming Birds in Nigeria. (scirp.org)
  • Okoye, J.O.A., Agu, A.O., Chineme, C.N. and Echeonwu, G.O.N. (2000) Pathological Characterization in Chicken of a Velogenic Newcastle Disease Virus Isolate from Guinea Fowl. (scirp.org)
  • This study was conducted to evaluate the effectiveness of vaccines for the protection against ND infection and virus-shedding period of velogenic Newcastle disease virus (vNDV) field strain after different immunization schemes. (scielo.br)
  • Based on the MDT results (39.6-56 hours) as well as the presence of lesions in the visceral organs, all the isolates can be grouped as viscerotrop velogenic Newcastle disease virus (WNOV) pathotype. (upm.edu.my)
  • Naturally occurring strains of Newcastle disease virus (NDV) have shown oncolytic therapeutic efficacy in preclinical studies and are currently in clinical trials. (aacrjournals.org)
  • Different strains of Newcastle disease virus (NDV) worldwide proved to have tumouricidal activity in several types of cancer cells. (springer.com)
  • The causative agents are virulent strains of Newcastle disease virus (NDV), which belong to the genus Avulavirus, sub-family Paramyxoviridae, family Paramyxovirinae. (biomedcentral.com)
  • Africa, a reservoir of new virulent strains of Newcastle disease virus? (cirad.fr)
  • For 20 years before this report, NDV was used in a vaccine to prevent Newcastle disease in birds. (emedicinehealth.com)
  • Reverse genetics technology enabled us to generate a new vaccine by exchanging a gene from the original vaccine with a similar gene of the current circulating virus. (thepoultrysite.com)
  • We found that when the new vaccine, containing gene sequences similar to the wild-type virus, was used in vaccination studies, the vaccinated birds were protected from disease and shed less of the wild-type virus after challenge. (thepoultrysite.com)
  • Our goal is to create a vaccine to decrease virus spread as well. (thepoultrysite.com)
  • We evaluated Newcastle disease virus (NDV), an avian paramyxovirus that is highly attenuated in primates, as a topical respiratory vaccine vector with SARS-CoV as a test pathogen. (pnas.org)
  • There is a clear need for a safe and effective vaccine should an outbreak of a SARS-like virus reoccur in humans. (pnas.org)
  • A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. (asm.org)
  • The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector. (asm.org)
  • An important application of reverse-genetic techniques is the generation of recombinant viruses for use as vaccine vectors (reviewed in references 4 , 8 , 19 , 21 , and 26 ). (asm.org)
  • In this paper, a recombinant NDV expressing the HA protein of influenza A virus was generated from the full-length cDNA of the avirulent strain Hitchner B1 (ATCC VR108), a widely used NDV live vaccine strain. (asm.org)
  • After complete resection of liver metastases, patients randomised to the vaccination group received six doses of Newcastle disease virus (NDV) infected autologous tumour cell vaccine (ATV-NDV). (springer.com)
  • Lehner B, Schlag P, Liebrich W, Schirrmacher V (1990) Postoperative active specific immunization in curatively resected colorectal cancer patients with a virus-modified autologous tumor cell vaccine. (springer.com)
  • demonstrated the efficacy (reduction of clinical signs and control of the spread of the virus) of a commercial killed vaccine containing the LaSota strain against velogenic genotype VII outbreaks in Korea. (thepoultrysite.com)
  • The use of cloned strains represents a technological breakthrough in these types of vaccines, since they make possible to have a completely uniform vaccine virus population, with specific viral characteristics, determined by the viral selection process. (thepoultrysite.com)
  • Newcastle Disease Virus (NDV) co-expressing IL7 and IL15 modified tumor cells as a vaccine for cancer immunotherapy. (bioportfolio.com)
  • In order to improve the antitumor activity by Newcastle Disease Virus (NDV)-modified tumor vaccine, we generated a recombinant NDV co-expressing IL15 and IL7 (LX/IL(15+7)) by incorporation of a 2A self-processing peptide into IL15 and IL7 using reverse genetics. (bioportfolio.com)
  • Then, the antitumor effects of tumor vaccine modified with recombinant virus were tested in the murine tumor models. (bioportfolio.com)
  • Non-replicating Newcastle Disease Virus as an adjuvant for DNA vaccine enhances antitumor efficacy through the Induction of TRAIL and granzyme B expression. (bioportfolio.com)
  • This phase II trial studies how well modified vaccinia virus ankara vaccine expressing p53 (p53MVA) and pembrolizumab work in treating patients with ovarian, primary peritoneal, or fallopi. (bioportfolio.com)
  • These lentogenic viruses were closely related to NDV vaccine strains used in Jeju Province. (koreamed.org)
  • Although the different vaccination regimens displayed close degrees of protection against the disease, the best protection was observed in broilers primed with the live B1 vaccine via eye drop simultaneously with inactivated vaccine at 8 days of age and boosted with B1 or LaSota via drinking water on day 18. (scielo.br)
  • We propose using this formulation as an alternative and improved NDV vaccine platform that can be exploited to control disease not only in Egypt but also in other disease-endemic countries. (lancs.ac.uk)
  • Eight Vietnamese Newcastle disease virus field isolates from 2008-2015 and 3 vaccine specimens were genotyped based on their full F gene sequences and compared to 80 reference strains representing all 18 genotypes. (springer.com)
  • Czeglédi A, Wehmann E, Lomniczi B (2003) On the origins and relationships of Newcastle disease virus vaccine strains Hertfordshire and Mukteswar, and virulent strain Herts'33. (springer.com)
  • for 8 days,14 days and 21 days, EID 50/(0.1?ml) of the best protection was decreased from 10 6.33 to 10 3.67,10 4.33 and 10 3.67.The result will be a hard stone for studying on the heat-resisting protections of Newcastle Disease Virus vaccine. (cnki.com.cn)
  • Development of a virosome vaccine for Newcastle disease virus. (semanticscholar.org)
  • Effects of Newcastle disease virus vaccine antibodies on the shedding and transmission of challenge viruses. (semanticscholar.org)
  • This study was conducted to determine the persistence of maternally derived antibodies (MDA) to Newcastle disease virus (NDV) in newly hatched chicks and the effect of MDA on vaccination with a very potent vaccine (Avinew® (VG/GA)). Individual variations of chicks in acquiring and maintaining MDA and in their response to vaccination were also investigated. (ajol.info)
  • METHODS: A total of 288 1-day-old male turkey poults were randomized into 6 groups as follow: Group T1: Turkeys received Echinacea purpurea at the rate of 1 ml /1 liter water and Newcastle disease virus (NDV) vaccine, Group T2: Turkeys received probiotic at the rate of 1 g /1 liter water and NDV vaccine, Group T3: Positive control that turkey received NDV vaccine without any additives. (ac.ir)
  • At age of 10 and 20 days, poults were vaccinated with Villegas_Glisson/University of Georgia (VG/GA) strain of Newcastle disease vaccine by eye dropper method. (ac.ir)
  • All future live attenuated ND vaccine licensing applications must include ICPI test results for each ND master seed virus used to produce the vaccine. (gc.ca)
  • Furthermore, the first spillover of a mesogenic Komarov vaccine virus is documented, suggesting a previous spillover and evolution of this virus. (up.ac.za)
  • Lineage 2 viruses were genetically identical or similar to the locally used LaSota vaccine strain and were mostly detected in commercial farms. (mysciencework.com)
  • While no recombination event was identified for the gene, constant molecular and pathological characterization of circulating NDVs are needed to detect an evolutionary feature of the viruses. (magiran.com)
  • Characterization of rNDV‑P05 indicates that the virus is slightly sensible to acid and basic pH, and stable at temperatures no greater than 42˚C. The majority of cell lines developed apoptosis in co‑culture with rNDV‑P05 in a dose‑time dependent manner. (spandidos-publications.com)
  • This is the first genetic characterization of NDV isolates from Namibia, and the findings have important implications for Newcastle disease management and control in the region. (deepdyve.com)
  • The failure to control ND with vaccination alone in countries where the virus is endemic underscores the importance of understanding the mechanisms of vNDV maintenance. (asm.org)
  • Epidemiological control of Newcastle disease in broilers is possible (amongst other tools) thanks to the intensive use of prophylactic vaccination. (thepoultrysite.com)
  • However, there are not many studies to evaluate the protection produced by live vaccines with other types of strains such as cloned strains of LaSota, combined vaccines against Newcastle and infectious bronchitis, vaccination programs or the administration routes used. (thepoultrysite.com)
  • The potential of non-replicating Newcastle Disease Virus (NDV) as an adjuvant for DNA vaccination remains to be elucidated. (bioportfolio.com)
  • Intensive vaccination strategies against Newcastle disease (ND) have been implemented in many countries for a long time, but ND outbreaks still occur frequently, with most isolates belonging to VII ge. (bioportfolio.com)
  • Vaccination and biosecurity are widely used as management practices for the protection against ND virus. (scielo.br)
  • Despite frequent vaccination, the high mortality and economical losses show that vaccination strategies were not able to completely prevent outbreaks against the currently circulating viruses. (scielo.br)
  • Despite extensive vaccination campaigns, Newcastle disease virus (NDV) remains endemic in many countries worldwide, and factors that contribute to this failure include mismatched vaccines, partial immunization, and poor husbandry practices. (lancs.ac.uk)
  • CONCLUSIONS: Results indicated that systemic and mucosal immunity of turkeys following vaccination against Newcastle disease (ND) could be improved by supplementation of Echinacea and probiotic. (ac.ir)
  • The review also presents future perspectives, including the concept of in situ vaccination and the combination of NDV or other oncolytic viruses with checkpoint inhibitors. (kanker-actueel.nl)
  • Despite recent progress in vaccination options, Newcastle disease virus (NDV) stands a severe global epidemic and economic burden. (usda.gov)
  • Fusion protein fuses the virus envelope to the cell membrane, enabling the virus to enter the host cell. (sify.com)
  • The endogenous NDV fusion (F) protein directs membrane fusion, which is required for virus entry and cell-cell fusion. (nih.gov)
  • All the isolates have a typical fusion protein cleavage site motif of velogenic viruses ( 112 R-R-Q-K-R-F 117 ). (bioone.org)
  • The results revealed that the polymerase-associated protein genes individually had certain effect on virulence, while transfer of these three genes in combination significantly affected the chimeric virus virulence, especially when the L gene was involved. (frontiersin.org)
  • Newcastle disease viruses can be classified into different genotypes based on the sequence and phylogenetic analysis of the F protein gene. (frontiersin.org)
  • Furthermore, inactivated whole-virus or protein subunit vaccines are not necessarily safe and effective: in the case of measles and respiratory syncytial virus, they induced altered immune responses, resulting in immune-mediated enhancement of disease upon subsequent exposure to the pathogen ( 12 , 13 ). (pnas.org)
  • A recombinant vesicular stomatitis virus (VSV) expressing the SARS-CoV S protein was protective in mice ( 14 ) but has not been tested in primates, and the safety of VSV in humans remains to be established. (pnas.org)
  • We previously used an attenuated version of human parainfluenza virus type 3, a common pediatric respiratory pathogen, to express the SARS-CoV S protein and showed that a single intranasal (i.n.) and intratracheal (i.t.) inoculation was immunogenic and protective against SARS-CoV challenge in hamsters and African green monkeys (AGM) ( 20 ). (pnas.org)
  • However, with the introduction of the most objective NDV genotyping criteria which utilize complete fusion protein coding sequences in phylogenetic taxonomy, the enormous genetic diversity of the virus in Nigeria became very conspicuous. (wur.nl)
  • Recombinant vesicular stomatitis viruses (VSVs) are able to express the human CD4 protein ( 32 ), the influenza virus hemagglutinin (HA) and neuraminidase ( 14 , 25 , 27 ), the respiratory syncytial virus G and F proteins ( 12 ), the human immunodeficiency virus Gag and Env proteins ( 10 ), and the bovine viral diarrhea virus E2 protein ( 9 ). (asm.org)
  • Among paramyxoviruses, several chimeric measles viruses and Sendai viruses expressing foreign genes have been constructed ( 29 , 35 , 38 ), and a rinderpest virus expressing an influenza virus HA protein has been described ( 37 ). (asm.org)
  • In addition, vesicular stomatitis virus (VSV) engineered to express this highly fusogenic F protein has shown increased oncolytic potential in treating hepatocellular carcinoma in the livers of immunocompetent rats ( 16 ). (aacrjournals.org)
  • The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is an important multifunctional envelope protein, which plays key roles in virus attachment, neuraminidase and fusion promotion activities. (umd.edu)
  • To study the effect of mutagenesis of such key amino acids on NDV pathogenesis in vivo, five recombinant viruses with mutations in residues at the receptor-binding domains of the HN protein and in residues differing between the LaSota and BC strains of NDV, were generated. (umd.edu)
  • Recombinant Newcastle disease virus (NDV) La Sota expressing the hemagglutinin-neuraminidase protein of genotype VII NDV shows improved protection efficacy against NDV challenge. (bioportfolio.com)
  • The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) with its immunotherapeutic activities and sialic acid binding abilities is a promising cancer adjuvant. (jcancer.org)
  • Newcastle disease virus (NDV) was isolated from six cases and confirmed by reverse transcriptase-polymerase chain reaction (RT-PCR) targeting the partial fusion protein gene of the viral genome. (pubmedcentralcanada.ca)
  • May be used as a capture antibody in ELISA assays for the HN protein of Newcastle disease virus. (lsbio.com)
  • Fusogenic activity of reconstituted newcastle disease virus envelopes: a role for the hemagglutinin-neuraminidase protein in the fusion process. (semanticscholar.org)
  • Liposome encapsulation of a soluble recombinant fragment of the respiratory syncytial virus (RSV) G protein enhances immune protection and reduces lung eosinophilia associated with virus challenge. (semanticscholar.org)
  • All isolates contained multiple basic amino acids at the deduced cleavage site of fusion protein, which is a typical feature of virulent viruses. (springeropen.com)
  • We evaluated the replication and antitumor characteristics of these viruses in vitro and in vivo. (wur.nl)
  • Moreover, studies on the HN UTRs replaced with corresponding NP UTRs virus suggested that UTRs can be exchanged between NDV mRNAs without affecting the replication of virus in vitro and in vivo. (umd.edu)
  • 13 , 18 , 30 , 32 ] During a replication cycle, new virus proteins and copies of the NDV genetic material (i.e., genome) are made in the host cell's cytoplasm. (peacehealth.org)
  • Genome replication of Newcastle disease virus: involvement of the rule-of-six Peeters, B. P. H. (deepdyve.com)
  • Gielkens, A. L. J. 2000-09-01 00:00:00 We examined replication of Newcastle disease virus (NDV) by using minigenomes consisting of the 3′ leader and 5′ trailer regions of NDV flanking a reporter gene encoding secreted placental alkaline phosphatase (SEAP). (deepdyve.com)
  • Various viruses have evolved a plethora of strategies to manipulate DNA damage machinery and commandeer cells to maximize their own replication. (pirbright.ac.uk)
  • Most studies have focused on the relationship between DNA virus replication and the host DDR pathway, but few have investigated the interface between the DDR pathway and ribonucleic acid (RNA) viruses, such as oncolytic Newcastle disease virus (NDV). (pirbright.ac.uk)
  • UV irradiation analysis of complementation between, and replication of, RNA-negative temperature-sensitive mutants of Newcastle disease virus. (semanticscholar.org)
  • Protective immunity against Newcastle disease: the role of antibodies specific to Newcastle disease virus polypeptides. (semanticscholar.org)
  • Recently, viral therapy for cancer (virotherapies) is known to have potential in cancer treatment, as some viruses have been found with oncolytic properties, having the ability to suppress cancer tumour. (hindawi.com)
  • In vitro and in vivo studies with these viruses indicated the important role of certain residues in viral infectivity. (umd.edu)
  • 8 ] described that virus-induced IFN-α and IFN-β are potent inducers of NK cell-mediated cytotoxicity and that NK cells are important contributors to innate defense against viral infections. (medsci.org)
  • Newcastle disease (ND), caused by the virulent Newcastle disease virus (NDV), is one of the most important viral diseases in birds. (magiran.com)
  • Newcastle disease (ND) is economically important and highly infectious viral disease of birds caused by virulent strains of avian paramyxovirus Type 1 of the genus Avulavirus belonging to the family Paramyxoviridae . (pubmedcentralcanada.ca)
  • Random UV irradiation-induced lesions destroy the infectivity of Newcastle disease virus (NDV) by blocking downstream transcription from the single viral promoter. (semanticscholar.org)
  • Once the virus gains entry to the host cancer cell it hijacks the cell machinery so it mistakenly copies the viral acids instead of its own nucleic acids. (medicalnewstoday.com)
  • The aim of this study were to investigate the possible pro-apoptotic mechanisms of the recombinant Newcastle disease virus (NDV) strain rL-RVG, which expresses the rabies virus glycoprotein, in A549 lung adenocarcinoma cells via the regulation of alpha 7 nicotinic acetylcholine receptors (α7 nAChRs) and to analyze the relationships between α7 nAChR expression in lung cancer and the clinical pathological features. (sigmaaldrich.com)
  • Glycoprotein hemagglutinin-neuraminidase of Newcastle Disease Virus (La-Sota strain). (lsbio.com)
  • The hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus (NDV) was obtained as a recombinant antigen in Rachiplusia nu larvae. (asm.org)
  • When they were mixed with glycoprotein components of Newcastle disease virus (NDV) obtained by treatment of purified virions with deoxycholate (DOC), the mixture showed hemagglutination reaction, which was inhibited by anti-NDV serum, but not by anti-HVJ serum. (eurekamag.com)
  • The biologically active form of the fusion glycoprotein F from Newcastle disease virus (NDV) comprises two polypeptides, F 1 and F 2 (derived from a precursor polypeptide F 0 by a post translational cleavage event), which are covalently linked together (F 1,2 ) by disulphide bonds. (microbiologyresearch.org)
  • Although NDV causes a potentially fatal, noncancerous disease (Newcastle disease) in birds, it causes only minor illness in humans. (oncolink.org)
  • Newcastle disease virus (NDV) is a virus that causes a deadly infection in many kinds of birds. (emedicinehealth.com)
  • It is suspected that the virus originated from wild birds and farmers in the area are being made aware to remove all foreign birds including pet birds from their farms. (ambergriscaye.com)
  • Therefore, the current vaccines do not eliminate virulent virus transmission from infected to healthy birds. (thepoultrysite.com)
  • NDV causes disease in more than 250 species of birds and typically affects the respiratory, gastrointestinal, and/or nervous system. (thepoultrysite.com)
  • Avian paramyxoviruses type 1 or Newcastle disease viruses (NDV) are frequently recovered from wild birds and such isolates are most frequently of low virulence. (bioone.org)
  • Newcastle disease virus (NDV) is a member of the Rubulavirus genus in the Paramyxoviridae family and is categorized into three pathotypes depending on the severity of the disease that it causes in birds: lentogenic, mesogenic, or velogenic ( 1 , 33 ). (asm.org)
  • Furthermore, the immune-challenge experiment indicated that LaSota could not provide complete protection against infection with the E347K variant NDVs as the vaccinated birds were still able to be infected and shed virulent challenge viruses. (biomedcentral.com)
  • The Newcastle disease virus (NDV) infects domestic and wild birds, having been described in at least 241 species. (pirbright.ac.uk)
  • The infectious recombinant viruses containing increased/decreased length of F-HN and HN-L IGS were recovered and the transcription and pathogenicity of mutants were characterized. (umd.edu)
  • We previously reported that Newcastle disease virus (NDV) recombinant LaSota strain (rLS) expressing infectious bronchitis virus (IBV) Arkansas-type (Ark) trimeric spike ectodomain (Se) (rLS/ArkSe) provides suboptimal protection against IBV challenge. (allenpress.com)
  • The genetic control of antibody (Ab) response to Escherichia coli (EC), infectious bursa disease virus, and Newcastle disease virus and the genetic and phenotypic correlation between these Ab responses, were evaluated under farm conditions in which chicks were simultaneously exposed to these antigens. (elsevier.com)
  • According to Alexander and Jones [ 3 ], NDV can be further divided into three pathotypes based on the virulence and severity of the disease, which are velogenic (highly contagious), mesogenic (moderate) and lentogenic (mild infection). (medsci.org)
  • The aetiology of the disease is an avian paramyxovirus type-1 or Newcastle disease virus (NDV), whose isolates are serologically grouped into a single serotype but genetically classified into a total of 19 genotypes, owing to the continuous emergence and evolution of the virus. (wur.nl)
  • We then discuss the challenges of ND control as a result of the wide genetic distance between the currently circulating NDV isolates and the commonest vaccines used to combat the disease in the country. (wur.nl)
  • The F gene cleavage site motif for all of the isolates was 112RRQKRF117, indicating that the viruses are virulent. (deepdyve.com)
  • A triple one-step RT-PCR was developed to screen and differentiate virulent from avirulent Newcastle disease virus (NDV) isolates. (up.ac.za)
  • In phylogenetic analysis, all Iranian isolates are grouped together with other virulent strains in group C. The Russian virulent strain, VOL 95, showed the same amino acid sequence with all the Iranian isolates except MK13 indicating a common origin of the viruses. (upm.edu.my)
  • The disease is associated with severe respiratory, gastrointestinal, and neurological lesions in chicken leading to high mortality and several other production related losses. (wur.nl)
  • After overnight incubation, the transfected cells were cocultured with chicken embryo fibroblasts (CEF) to amplify the produced virus and then incubated for an additional 2 to 3 days. (asm.org)
  • Growth curves of wtNDV/B1, rNDV/B1, rNDV/B1-CAT, and rNDV/B1-HA viruses in embryonated chicken eggs. (asm.org)
  • NDV is a virus tht is harmful in chicken, but harmless in man. (bioportfolio.com)
  • Diagnosis of velogenic viscerotropic Ranikhet disease from six different flocks of desi chicken in and around Mumbai by gross and histopathological examination, isolation of virus and molecular methods. (pubmedcentralcanada.ca)
  • A total of 25 carcasses (varying between 2 and 6 carcasses from each flock) of six different flocks of adult desi chicken were subjected to necropsy examination for diagnosis of the disease during the span of a year (2014-2015). (pubmedcentralcanada.ca)
  • A Newcastle disease virus was isolated from a chicken from a live bird market in the Mbeya region of Tanzania. (asm.org)
  • This virus was isolated from a chicken in 2012, and the obtained sequence represents the first subgenotype Vd complete genome. (asm.org)
  • Depending upon the disease signs and lesions in chicken, NDV can be classified into four groups/pathotypes: apathogenic (avirulent), low virulent (lentogenic), moderately virulent (mesogenic), highly virulent (velogenic). (pirbright.ac.uk)
  • Lytic strains of NDV have been studied in humans for their ability to kill cancer cells directly, but viruses of both strain types have been used to make vaccines in an attempt to stimulate the immune system to fight cancer. (oncolink.org)
  • Vaccines for ND have been used for more than 50 years to control the disease and are successful in reducing mortality and the severity of symptoms. (thepoultrysite.com)
  • The appearance of very aggressive outbreaks of Newcastle disease is caused by velogenic strains with genotypes different from those present in the classic vaccines currently being used, resulting in doubts about the efficacy of classical live attenuated vaccines. (thepoultrysite.com)
  • In general, the most common vaccines in the world against this disease are based on two main genotypes of live lentogenic NDV (genotype I and II), characterised by low pathogenicity or apathogenicity. (thepoultrysite.com)
  • The genetic divergence between the genotypes of the vaccines and the circulating viruses raises questions about their efficacy. (thepoultrysite.com)
  • This memorandum serves to notify regulated Canadian veterinary biologics manufacturers and importers of the requirement for filing intracerebral pathogenicity index (ICPI) test results for all master seed viruses that are used to produce live attenuated Newcastle Disease (ND) virus vaccines. (gc.ca)
  • Canadian importers and manufacturers of ND vaccines licensed prior to December 1, 2010, were contacted earlier in 2010 and required to submit ICPI test results for all master seed viruses used to produce licensed ND vaccines. (gc.ca)
  • We chose the newly introduced Xba I site, located between the P and M genes to insert the CAT gene ( 24 ) or the HA gene of influenza A/WSN/33 virus ( 7 ). (asm.org)
  • B) The pNDV/B1-CAT and pNDV/B1-HA constructs were made by inserting the CAT and influenza virus A/WSN/33 HA open reading frames (ORF), respectively, into the unique Xba I cloning site (nt 3163) located between the P and M genes of the pNDV/B1 clone. (asm.org)
  • The testing requirements for recombinant master seed viruses containing ND virus genes will be determined on a case-by-case basis. (gc.ca)
  • Based on genomic size and the nucleotide sequences of F and L genes, NDVs can be categorized as class I or class II viruses. (springeropen.com)
  • A number of recombinant negative-strand RNA viruses expressing foreign proteins have been constructed. (asm.org)
  • To enhance the immune system, immunostimulatory agents such as chemicals, proteins, and viruses are needed [ 1 ]. (medsci.org)
  • Biochemical analysis indicated that the NDV virosomes had similar characteristics as the parent virus and contained both the fusion and hemagglutinin-neuraminidase proteins. (semanticscholar.org)
  • The existence of intermolecular disulphide bonds, orientation and relative lengths of the two NDV HN fragments is analogous to the HA 1 and HA 2 proteins of influenza virus haemagglutinin. (microbiologyresearch.org)
  • indicating that genotype VII NDV is the predominant virus currently circulating in the world and constituting the fourth panzootic strain of NDV. (frontiersin.org)
  • Wen G, Wang M, Wang H, Li L, Luo Q, Zhang T, Cheng G, Shao H (2016) Genome sequence of a virulent genotype III Newcastle disease virus isolated from laying ducks in China. (springer.com)
  • In this study, the immunomodulatory effects of low titers of Newcastle disease virus (NDV) AF2240 on human peripheral blood mononuclear cells (PBMC) were analyzed. (medsci.org)
  • Egbal Sidahmed Abdelrahim and Jedda Elhag, "A Case of Newcastle Disease Virus in Red-Headed Lovebird in Sudan," Case Reports in Veterinary Medicine , vol. 2014, Article ID 704239, 2 pages, 2014. (hindawi.com)
  • It would be important to further investigate the molecular mechanism underlaying cytokines production by Newcastle disease virus. (springer.com)
  • The disease can be categorized as velogenic (highly virulent), mesogenic (intermediate virulence) and lentogenic (non-virulent). (ambergriscaye.com)
  • Conclusion: As was shown by the successful rapid detection and pathotyping of 15 NDV strains in clinical samples representing velogenic and lentogenic NDV strains, and the agreement with the results of virus isolation , biological pathotyping and pathogenicity indices. (scopemed.org)
  • This ICPI testing must be conducted for each master seed virus, even if the master seed virus is derived from a known lentogenic ND virus strain. (gc.ca)
  • The virulence of Newcastle disease virus varies greatly and is determined by multiple genetic factors. (frontiersin.org)
  • In addition, this study will provide data on human and animal viruses (RV and NDV respectively) to be used in oncolytic virotherapy for which host-range and/or virulence and/or immunogenic potential were increased on purpose. (nwo.nl)
  • The disease, on the basis of virulence and clinical signs, is characterized into different pathotypes, viz. (pubmedcentralcanada.ca)
  • Newcastle Disease Virus antibody LS-C58372 is an unconjugated mouse monoclonal antibody to virus Newcastle Disease Virus (NDV). (lsbio.com)
  • The Belize Agricultural Health Authority (BAHA) convened an emergency meeting yesterday Thursday 27th November at Central Farm to disseminate pertinent information to key stakeholders on an outbreak of Newcastle Disease. (ambergriscaye.com)
  • ND is clinically similar to avian influenza, and the two diseases may be confused, which impairs the rapid diagnosis of a disease outbreak. (thepoultrysite.com)
  • Leslie, J. (2000) Newcastle Disease: Outbreak Losses and Control Policy Costs. (scirp.org)
  • A procedure has been developed for the determination of the concentration of infective Newcastle disease virus (NDV) based on the enumeration of singly infected and distributed HeLa cells which are visualized by staining with fluorescent antibody. (rupress.org)
  • Antibody titers were assayed by hemagglutination inhibition test and fecal virus shedding was determined for 14 days post challenge (dpc) with 3-day intervals by the RT-PCR method. (scielo.br)
  • New Castle Virus (NDV) has a long history as a broad system oncolytic that can destroy tumor cells and stimulate the immune system. (knowcancer.com)
  • These inherent oncolytic properties, shared by several viruses (including NDV), are believed to derive, at least in part, from defective IFN signaling pathways in tumor cells ( 7 , 8 ). (aacrjournals.org)
  • These viruses target and kill tumor cells while leaving normal healthy cells intact. (medicalnewstoday.com)
  • It is also an oncolytic virus that targets tumor cells and has shown promise in human clinical trials for various types of cancer. (medicalnewstoday.com)
  • By exchanging the HN gene between an avirulent NDV strain LaSota and a virulent NDV strain Beaudette C (BC), two chimeric viruses were generated. (umd.edu)
  • Here, we report a novel NDV vector harboring an L289A mutation within the F gene, which resulted in enhanced fusion and cytotoxicity of hepatocellular carcinoma (HCC) cells in vitro, as compared with the rNDV/F3aa control virus. (nih.gov)
  • Here, we assessed the ability of a novel dual-specific anti-tumor oncolytic adenovirus, expressing the hemagglutinin-neuraminidase (HN) gene from the Newcastle disease virus under the human telomerase reverse transcriptase (hTERT) promoter (Ad-hTERTp-E1a-HN), to inhibit esophageal cancer EC-109 cells in culture and to reduce tumor burden in xenografted BALB/c nude mice. (mdpi.com)
  • A phylogenetic analysis using the full F gene sequence revealed that the viruses belong to a novel subgenotype, VIIk. (deepdyve.com)
  • Gene expression profiles showed that the expression of IL-1beta , TNF-α-like factor ( LITAF ) and interferon (IFN)-beta was upregulated in both CEFs and DEFs infected with SS-10 and NH-10 viruses or treated with polyinosinic:polycytidylic acid [poly(I:C)], as well as that expression levels were greater in CEFs than in DEFs. (biomedcentral.com)
  • Several strains of the Newcastle disease virus (NDV) have been used as oncolytics in vitro and in a number of in vivo experiments. (mdpi.com)
  • Recombinant Newcastle disease virus rL-RVG enhances the apoptosis and inhibits the migration of A549 lung adenocarcinoma cells via regulating alpha 7 nicotinic acetylcholine receptors in vitro. (sigmaaldrich.com)
  • Contact with wild species, introduction of new live animals, and legal and illegal movement of animals are all thought to have exacerbated the spread of the disease. (thepoultrysite.com)
  • This is especially significant when considering that some viruses were isolated from species of conservation concern. (up.ac.za)
  • There is limited knowledge about the avian immune response to infection with virulent NDVs, and how this response may contribute to disease. (nih.gov)
  • Furthermore, the intracellular perforin and granzyme levels were also increased upon virus infection. (medsci.org)
  • 5 ] showed that activated human peripheral blood mononuclear cells (PBMC) exerted a cytotoxic effect on melanoma, colon cancer and breast carcinoma, upon influenza A virus infection. (medsci.org)
  • Infection of Commercial Laying Hens with Newcastle Disease Virus: Diff" by Kaylee Rowland, Huaijun Zhou et al. (iastate.edu)
  • Eventually the cell becomes so full of virus copies that it bursts, releasing its surrogate progeny to infect other host cells, and so the anti-cancer "infection" spreads. (medicalnewstoday.com)
  • But the clinical trial results with NDV have not been good enough because successful treatment requires many large injections of the virus, probably because not enough of the virus managed to reach the solid tumors and so the infection did not spread very well to other cancer cells. (medicalnewstoday.com)
  • Exosomes carry microRNAs into neighbouring cells to promote diffusive infection of Newcastle disease virus. (greenmedinfo.com)
  • Induction of immune responses in mice and monkeys to Ebola virus after immunization with liposome-encapsulated irradiated Ebola virus: protection in mice requires CD4(+) T cells. (semanticscholar.org)
  • NDV is usually thought to be an avian (i.e., bird) virus, but it also infects humans. (oncolink.org)
  • Like other viruses , NDV infects cells (called host cells) and then uses those cells to replicate (make copies of) itself. (emedicinehealth.com)
  • As explained in Question 1, NDV infects cells and then replicates itself, creating more copies of the virus that can then infect cells throughout the body. (emedicinehealth.com)
  • Newcastle Disease virus (NDV) is classified into different classes and genotypes based on its genetic characteristics. (thepoultrysite.com)
  • Diel DG, da Silva LH, Liu H, Wang Z, Miller PJ, Afonso CL (2012) Genetic diversity of avian paramyxovirus type 1: proposal for a unified nomenclature and classification system of Newcastle disease virus genotypes. (springer.com)
  • Phylogenetic analysis revealed that viruses of seven different genotypes circulated in that period, demonstrating high genetic diversity of NDV for a single country. (up.ac.za)
  • The modified virus is now ready to be tested in preclinical animal models, and possibly in phase I human clinical trials. (sify.com)
  • It is an oncolytic virus that hones in on tumors, and has shown promising results in a number of human clinical trials for various forms of cancer. (sify.com)
  • Newcastle disease virus (NDV)- based therapy has been reported to be of benefit in clinical studies, but results are considered inconclusive. (oncolink.org)
  • Answers are provided based on specific data or on considerations drawn from experience (the authors use NDV oncolysates to immunize against melanoma and kidney carcinoma) or from analogous clinical situations (therapeutic use of mumps or measles viruses). (nih.gov)
  • Newcastle disease virus (NDV) is an intrinsically tumor-specific virus, which is currently under investigation as a clinical oncolytic agent. (nih.gov)
  • Reports from phase I and II clinical trials using naturally occurring strains of NDV as oncolytic agents show promise and warrant investigation into methods of improving the therapeutic potential of these viruses ( 12 , 13 ). (aacrjournals.org)
  • however, it is sufficient to ameliorate the clinical outcome of these RNA viruses. (figshare.com)
  • Taken together, our study provides a novel platform to develop recombinant oncolytic viruses based on the NDV Italien strain and shows the efficiency of recombinant NDV Italien for oncolytic virotherapy of tumors. (wur.nl)
  • This study will provide data on host range-modified human viruses (RV), and attenuated avian viruses (NDV) to be used in oncolytic virotherapy. (nwo.nl)
  • In addition, these studies will serve as a paradigm for data acquisition on human and non-human genetically modified viruses with altered biological traits, that are rapidly gaining attention for use in oncolytic virotherapy globally. (nwo.nl)
  • While genetically engineered viruses are now being tested for the virus therapy of human cancers, some naturally occurring viruses display unmatched oncolytic activity. (nih.gov)
  • The ability to genetically engineer negative-strand RNA viruses has led to extraordinary advances in understanding their biology. (asm.org)
  • Furthermore, mice in a CT26 metastatic tumor model treated with an i.v. injection of the genetically engineered NDV exhibited prolonged survival compared with wild-type control virus. (aacrjournals.org)
  • This ICPI testing requirement will apply to naturally derived attenuated master seed viruses, as well as genetically modified ND master seed viruses. (gc.ca)
  • Newcastle disease (ND) is caused by virulent forms of avian Paramyxovirus serotype 1 (APMV-1). (thepoultrysite.com)
  • Immunotherapy refers to the treatment of a disease by strengthening the body's immune system. (medsci.org)
  • Their findings suggested the potential of using virus to enhance the anticancer activity of the human immune system. (medsci.org)
  • Therapies including the use of oncolytic viruses, particularly the Newcastle disease virus (NDV), have emerged as an attractive alternative due to their capacity to kill cancer cells directly or through stimulation of the immune system. (spandidos-publications.com)
  • This avian virus combines, upon inoculation into non-permissive hosts such as human, 12 described anti-neoplastic effects with 11 described immune stimulatory properties. (kanker-actueel.nl)
  • Considering that the disease is endemic to the region one wonders why the chicks are not routinely vaccinated. (ambergriscaye.com)
  • The gross and histopathological examination revealed lesions suggestive of viscerotropic velogenic form of the Newcastle disease (ND). (pubmedcentralcanada.ca)
  • Newcastle disease virus (NDV) known as Avian paramyxovirus type-1 (APMV1) belongs to the genus Avulavirus in a family Paramyxoviridae. (hindawi.com)
  • Recombinant Newcastle disease virus (rNDV), a non-segmented negative-sense RNA virus (NSNSV), was first rescued in 1999 using a reverse genetics approach similar to that reported for other recombinant viruses of the order Mononegavirales a few years before. (wur.nl)
  • The current research work was performed to isolate and detect Newcastle disease virus (NDV) by using haemagglutination inhibition (HI) test and reverse transcription-polymerase chain reaction (RT-PCR) assay. (weltbild.ch)
  • Initially three diseases were suspected including Avian Influenza. (ambergriscaye.com)
  • Confirmation was made by a World Organization for Animal Health (OIE) Lab in the US that the disease is Virulent Newcastle Disease and NOT Avian Influenza. (ambergriscaye.com)
  • Influenza A/WSN/33 virus was purified from MDBK cell culture supernatants as a control. (asm.org)
  • Average body weights of vaccinated mice after influenza virus challenge. (asm.org)
  • Vaccinated mice were challenged with a lethal dose (100 LD 50 ) of influenza A/WSN/33 virus on day 35 (2 weeks after the booster injection). (asm.org)
  • Newcastle disease virus (NDV) and H9 subtype avian influenza virus (AIV) are two avian pathogens across the globe. (bioportfolio.com)