Neutropenia. Medical search

A decrease in the number of NEUTROPHILS found in the blood.

A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

Fever accompanied by a significant reduction in the number of NEUTROPHILS.

FEVER accompanied by a significant reduction in NEUTROPHIL count associated with CHEMOTHERAPY.

An abnormal elevation of body temperature, usually as a result of a pathologic process.

A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.

The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.

Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.

A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.

A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.

The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

A subnormal level of BLOOD PLATELETS.

The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

A rare complication of rheumatoid arthritis with autoimmune NEUTROPENIA; and SPLENOMEGALY.

An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.

Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.

Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)

Disorders of the blood and blood forming tissues.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Receptors that bind and internalize GRANULOCYTE COLONY-STIMULATING FACTOR. Their MW is believed to be 150 kD. These receptors are found mainly on a subset of myelomonocytic cells.

An organoplatinum compound that possesses antineoplastic activity.

Fever in which the etiology cannot be ascertained.

A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.

Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.

Organic compounds which contain platinum as an integral part of the molecule.

The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.

Infections by bacteria, general or unspecified.

An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.

Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.

An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.

Tumors or cancer of the LUNG.

Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.

The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.

An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.

Proteins prepared by recombinant DNA technology.

The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.

A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.

A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.

Antimetabolites that are useful in cancer chemotherapy.

The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

The giving of drugs, chemicals, or other substances by mouth.

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.

A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)

The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.

Antagonist of urate oxidase.

Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.

Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.

Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.

Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.

Infections with fungi of the genus ASPERGILLUS.

A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).

The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.

Use of antibiotics before, during, or after a diagnostic, therapeutic, or surgical procedure to prevent infectious complications.

Therapeutic act or process that initiates a response to a complete or partial remission level.

Substances that reduce the growth or reproduction of BACTERIA.

Absence of hair from areas where it is normally present.

The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.

The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.

Therapy with two or more separate preparations given for a combined effect.

An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)

Tumors or cancer of the human BREAST.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.

Elements of limited time intervals, contributing to particular results or situations.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

The forcible expulsion of the contents of the STOMACH through the MOUTH.

An anthracenedione-derived antineoplastic agent.

An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)

Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.

A malignant epithelial tumor with a glandular organization.

A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.

An autosomal recessive disease in which gene expression of glucose-6-phosphatase is absent, resulting in hypoglycemia due to lack of glucose production. Accumulation of glycogen in liver and kidney leads to organomegaly, particularly massive hepatomegaly. Increased concentrations of lactic acid and hyperlipidemia appear in the plasma. Clinical gout often appears in early childhood.

A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.

Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.

Antibodies obtained from a single clone of cells grown in mice or rats.

Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.

The number of PLATELETS per unit volume in a sample of venous BLOOD.

Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.

Rare congenital X-linked disorder of lipid metabolism. Barth syndrome is transmitted in an X-linked recessive pattern. The syndrome is characterized by muscular weakness, growth retardation, DILATED CARDIOMYOPATHY, variable NEUTROPENIA, 3-methylglutaconic aciduria (type II) and decreases in mitochondrial CARDIOLIPIN level. Other biochemical and morphological mitochondrial abnormalities also exist.

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.

Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.

An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).

Excess of normal lymphocytes in the blood or in any effusion.

Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.

Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.

A subspecialty of internal medicine concerned with morphology, physiology, and pathology of the blood and blood-forming tissues.

Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.

Glycoproteins found in a subfraction of normal mammalian plasma and urine. They stimulate the proliferation of bone marrow cells in agar cultures and the formation of colonies of granulocytes and/or macrophages. The factors include INTERLEUKIN-3; (IL-3); GRANULOCYTE COLONY-STIMULATING FACTOR; (G-CSF); MACROPHAGE COLONY-STIMULATING FACTOR; (M-CSF); and GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; (GM-CSF).

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)

Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.

The return of a sign, symptom, or disease after a remission.

Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.

Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure.

A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)

Formation of MYELOID CELLS from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via MYELOID STEM CELLS. Myelopoiesis generally refers to the production of leukocytes in blood, such as MONOCYTES and GRANULOCYTES. This process also produces precursor cells for MACROPHAGE and DENDRITIC CELLS found in the lymphoid tissue.

Tumors or cancer of the STOMACH.

An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)

Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.

An enzyme that catalyzes the conversion of D-glucose 6-phosphate and water to D-glucose and orthophosphate. EC 3.1.3.9.

Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.

Antibodies produced by a single clone of cells.

An autosomal recessive syndrome occurring principally in females, characterized by the presence of reticulated, atrophic, hyperpigmented, telangiectatic cutaneous plaques, often accompanied by juvenile cataracts, saddle nose, congenital bone defects, disturbances in the growth of HAIR; NAILS; and TEETH; and HYPOGONADISM.

Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.

An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.

A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.

Clinical sign or symptom manifested as debility, or lack or loss of strength and energy.

Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)

A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.

Pulmonary diseases caused by fungal infections, usually through hematogenous spread.

Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.

Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.

An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)

Reduction in the number of lymphocytes.

Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.

Injections made into a vein for therapeutic or experimental purposes.

Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.

Compounds that inhibit the activity of DNA TOPOISOMERASE I.

Tumors or cancer of the PERITONEUM.

Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity. (1/2974)

Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme of 5-fluorouracil (5-FU) catabolism. We report lymphocytic DPD data concerning a group of 53 patients (23 men, 30 women, mean age 58, range 36-73), treated by 5-FU-based chemotherapy in different French institutions and who developed unanticipated 5-FU-related toxicity. Lymphocyte samples (standard collection procedure) were sent to us for DPD determination (biochemical method). Among the whole group of 53 patients, 19 had a significant DPD deficiency (DD; below 150 fmol min(-1) mg(-1) protein, i.e. less than 70% of the mean value observed from previous population study). There was a greater majority of women in the DD group (15 out of 19, 79%) compared with the remaining 34 patients (15 out of 34, 44%, P<0.014). Toxicity was often severe, leading to patient death in two cases (both women). The toxicity score (sum of WHO grading, theoretical range 0-20) was twice as high in patients with marked DD (below 100 pmol min(-1) mg(-1) protein, n = 11, mean score = 13.2) compared with patients with moderate DD (between 150 and 100 pmol min(-1) mg(-1) protein, n = 8, mean score = 6.8), P = 0.008. In the DD group, there was a high frequency of neurotoxic syndromes (7 out of 19, 37%). The two deceased patients both had severe neurotoxicity. The occurrence of cardiac toxicity was relatively rare (1 out of 19, 5%). These data suggest that women are particularly prone to DPD deficiency and allow a more precise definition of the DD toxicity profile. (+info)

Itraconazole oral solution as prophylaxis for fungal infections in neutropenic patients with hematologic malignancies: a randomized, placebo-controlled, double-blind, multicenter trial. GIMEMA Infection Program. Gruppo Italiano Malattie Ematologiche dell' Adulto. (2/2974)

To evaluate the efficacy and safety of itraconazole oral solution for preventing fungal infections, a randomized, placebo-controlled, double-blind, multicenter trial was conducted: 405 neutropenic patients with hematologic malignancies were randomly assigned to receive either itraconazole, 2.5 mg/kg every 12 hours (201 patients), or placebo (204 patients). Proven and suspected deep fungal infection occurred in 24% of itraconazole recipients and in 33% of placebo recipients, a difference of 9 percentage points (95% confidence interval [CI], 0.6% to 22.5%; P = .035). Fungemia due to Candida species was documented in 0.5% of itraconazole recipients and in 4% of placebo recipients, a difference of 3.5 percentage points (95% CI, 0.5% to 6%; P = .01). Deaths due to candidemia occurred in none of the itraconazole recipients compared with 4 placebo recipients, a difference of 2 percentage points (95% CI, 0.05% to 4%; P = .06). Aspergillus infection was documented in four itraconazole recipients (one death) and one placebo recipient (one death). Side effects causing drug interruption occurred in 18% of itraconazole recipients and 13% of placebo recipients. Itraconazole oral solution was well-tolerated and effectively prevented proven and suspected deep fungal infection as well as systemic infection and death due to Candida species. (+info)

Randomized placebo-controlled trial of fluconazole prophylaxis for neutropenic cancer patients: benefit based on purpose and intensity of cytotoxic therapy. The Canadian Fluconazole Prophylaxis Study Group. (3/2974)

A randomized, double-blind trial comparing oral fluconazole (400 mg daily) with placebo as prophylaxis for adult patients receiving intensive cytotoxic therapy for acute leukemia or autologous bone marrow transplantation was conducted in 14 Canadian university-affiliated hospitals. Although fluconazole prophylaxis did not obviate the need for parenteral antifungal therapy compared with placebo (81 [57%] of 141 vs. 67 [50%] of 133, respectively), its use resulted in fewer superficial fungal infections (10 [7%] of 141 vs. 23 [18%] of 131, respectively; P = .02) and fewer definite and probable invasive fungal infections (9 vs. 32, respectively; P = .0001). Fluconazole recipients had fewer deaths attributable to definite invasive fungal infection (1 of 15 vs. 6 of 15, respectively; P = .04) and achieved more frequent success without fungal colonization (52 [37%] of 141 vs. 27 [20%] of 133, respectively; P = .004; relative risk reduction, 85%) than did placebo recipients. Patients benefiting the most from fluconazole prophylaxis included those with acute myeloid leukemia who were undergoing induction therapy with cytarabine plus anthracycline-based regimens and those receiving marrow autografts not supported with hematopoietic growth factors. Fluconazole prophylaxis reduces the incidence of superficial fungal infection and invasive fungal infection and fungal infection-related mortality among patients who are receiving intensive cytotoxic chemotherapy for remission induction. (+info)

The evolution of antibiotic therapy for neutropenic patients. (4/2974)

Considerable progress has been made in the treatment of infections in neutropenic patients during the past three decades. A major contribution to this progress has been the discovery of effective new therapies and their prompt administration. Unfortunately, successful therapy of each important pathogen has resulted in the emergence of new pathogens, usually with unique patterns of antibiotic susceptibility. Unfortunately, antibiotic resistance has become an increasing threat in recent years, raising the possibility of infections that will be difficult to eradicate. Fortunately, there are new classes of antimicrobials that hold promise for therapeutic success in the future. (+info)

Protein kinase C mediates experimental colitis in the rat. (5/2974)

Protein kinase C (PKC) plays an important role in the cell signal transduction of many physiological processes. In contrast to these physiological responses, increases in PKC activity have also been associated with inflammatory disease states, including ulcerative colitis. The objective of this study was to examine the role of PKC as a causative mediator in initiation of experimentally induced colitis in the rat. Colitis was induced in rats by intrarectal (0.6 ml) instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS; 75 mg/kg in 50% ethanol) or the PKC activator phorbol 12-myristate 13-acetate (PMA; 1.5-3.0 mg/kg in 20% ethanol). Gross and histological mucosal damage, mucosal neutrophil infiltration, mucosal PKC activity, and PKC protein content for PKC isoforms alpha, beta, delta, and epsilon were assessed 2 h to 14 days after an inflammatory challenge. Both PKC activity and mucosal injury increased significantly within 4 h of TNBS treatment. PKC activity was maximal at 7 days and declined at 14 days, whereas mucosal damage became maximal at 1 day and declined after 7 days. In contrast, neutrophil infiltration as assessed by myeloperoxidase activity only increased 12 h after TNBS treatment, became maximal 1 day after TNBS administration, and declined thereafter. PKCbeta, -delta, and -epsilon were increased in response to TNBS, whereas PKCalpha protein content was decreased. The PKC antagonists staurosporine and GF-109203X (25 ng/kg iv) reduced TNBS-induced changes in mucosal PKC activity and the degree of mucosal damage. In contrast, neutropenia induced by antineutrophil serum treatment did not significantly affect the degree of injury or mucosal PKC activity. Furthermore, activation of mucosal PKC activity with PMA also induced mucosal damage, which was also inhibited by pretreatment with a PKC antagonist. In conclusion, these results suggest that increases in PKC activity play a causative role in TNBS-induced colitis. The PKC-mediated response to TNBS does not appear to involve neutrophil infiltration. (+info)

A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq (nolatrexed dihydrochloride) given by 10-day oral administration. (6/2974)

2-Amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (nolatrexed dihydrochloride, Thymitaq, AG337), a specific inhibitor of thymidylate synthase, was developed using protein structure-based drug design. Intravenously administered nolatrexed is active clinically. As oral bioavailability is high (70-100%), nolatrexed was administered orally, 6 hourly for 10 days, at 3-week intervals, and dose escalated from 80 to 572 mg m(-2) day(-1) in 23 patients. Common toxicity criteria (CTC) grade 3 toxicities included nausea, vomiting, stomatitis and liver function test (LFT) abnormalities. Thrombocytopenia (grade 1 or 2) occurred at doses > or = 318 mg m(-2) day(-1) and neutropenia (grade 2) at 429 and 572 mg m(-2) day(-1). An erythematous maculopapular rash occurred at dosages > or = 318 mg m(-2) day(-1) (7 out of 19 patients). LFT abnormalities occurred in two out of six patients (grade 3 or 4 bilirubin and grade 3 alanine transaminase) at 572 mg m(-2) day(-1). Nolatrexed plasma concentrations 1 h after dosing were 6-16 microg ml(-1), and trough 3-8 microg ml(-1), at 572 mg m(-2) day(-1). Inhibition of thymidylate synthase was demonstrated by elevation of plasma deoxyuridine. Six-hourly oral nolatrexed for 10 days was associated with antiproliferative effects, but nausea and vomiting was dose limiting at 572 mg m(-2) day(-1). Nine patients were treated at 429 mg m(-2) day(-1); three out of nine experienced grade 3 nausea, but 17 out of 22 treatment courses were completed (with the co-administration of prophylactic antiemetics) and this dose level could be considered for phase II testing. (+info)

Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer. (7/2974)

PURPOSE: To evaluate the feasibility of administering topotecan in combination with paclitaxel and cisplatin without and with granulocyte colony-stimulating factor (G-CSF) support as first-line chemotherapy in women with incompletely resected stage III and stage IV ovarian carcinoma. PATIENTS AND METHODS: Starting doses were paclitaxel 110 mg/m2 administered over 24 hours (day 1), followed by cisplatin 50 mg/m2 over 3 hours (day 2) and topotecan 0.3 mg/m2/d over 30 minutes for 5 consecutive days (days 2 to 6). Treatment was repeated every 3 weeks. After encountering dose-limiting toxicities (DLTs) without G-CSF support, the maximum-tolerated dose was defined as 5 microg/kg of G-CSF subcutaneously starting on day 6. RESULTS: Twenty-one patients received a total of 116 courses at four different dose levels. The DLT was neutropenia. At the first dose level, all six patients experienced grade 4 myelosuppression. G-CSF support permitted further dose escalation of cisplatin and topotecan. Nonhematologic toxicities, primarily fatigue, nausea/vomiting, and neurosensory neuropathy, were observed but were generally mild. Of 15 patients assessable for response, nine had a complete response, four achieved a partial response, and two had stable disease. CONCLUSION: Neutropenia was the DLT of this combination of paclitaxel, cisplatin, and topotecan. The recommended phase II dose is paclitaxel 110 mg/m2 (day 1), followed by cisplatin 75 mg/m2 (day 2) and topotecan 0.3 mg/m2/d (days 2 to 6) with G-CSF support repeated every 3 weeks. (+info)

Pneumonia in febrile neutropenic patients and in bone marrow and blood stem-cell transplant recipients: use of high-resolution computed tomography. (8/2974)

PURPOSE: To obtain statistical data on the use of high-resolution computed tomography (HRCT) for early detection of pneumonia in febrile neutropenic patients with unknown focus of infection. MATERIALS AND METHODS: One hundred eighty-eight HRCT studies were performed prospectively in 112 neutropenic patients with fever of unknown origin persisting for more than 48 hours despite empiric antibiotic treatment. Fifty-four of these studies were performed in transplant recipients. All patients had normal chest roentgenograms. If pneumonia was detected by HRCT, guided bronchoalveolar lavage was recommended. Evidence of pneumonia on chest roentgenograms during follow-up and micro-organisms detected during follow-up were regarded as documentation of pneumonia. RESULTS: Of the 188 HRCT studies, 112 (60%) showed pneumonia and 76 were normal. Documentation of pneumonia was possible in 61 cases by chest roentgenography or micro-organism detection (54%) (P < 10(-6)). Sensitivity of HRCT was 87% (88% in transplant recipients), specificity was 57% (67%), and the negative predictive value was 88% (97%). A time gain of 5 days was achieved by the additional use of HRCT compared to an exclusive use of chest roentgenography. CONCLUSION: The high frequency of inflammatory pulmonary disease after a suspicious HRCT scan (> 50%) proves that pneumonia is not excluded by a normal chest roentgenogram. Given the significantly longer duration of febrile episodes in transplant recipients, HRCT findings are particularly relevant in this subgroup. Patients with normal HRCT scans, particularly transplant recipients, have a low risk of pneumonia during follow-up. All neutropenic patients with fever of unknown origin and normal chest roentgenograms should undergo HRCT. (+info)

"Neutropenia". The Lecturio Medical Concept Library. Retrieved 15 August 2021. Circular of Information for Blood Products (CS1 ... The product is collected by automated apheresis and is used for systemic infections in patients with neutropenia. The donor is ...

https://en.wikipedia.org/wiki/Leukapheresis

In Felty's syndrome, chronic activation of neutrophils progresses to neutropenia and unabated infections. Neutropenia is a ... neutropenia). As a result of neutropenia, affected individuals are increasingly susceptible to certain infections. ... Splenectomy may improve neutropenia in severe disease. Use of rituximab and leflunomide have been proposed. Use of gold therapy ... A major challenge in treating FS is recurring infection caused by neutropenia. Therefore, in order to decide upon and begin ...

https://en.wikipedia.org/wiki/Felty's_syndrome

The terms refractory neutropenia and refractory thrombocytopenia have sometimes been used to describe these cases. A diagnosis ... "Neutropenia". The Lecturio Medical Concept Library. Retrieved 15 August 2021. Myelodysplastic Syndrome. The Leukemia & Lymphoma ... Occasionally, cases of MDS present with isolated neutropenia or thrombocytopenia without anemia and with dysplastic changes ... severe neutropenia or thrombocytopenia; high blast count in the bone marrow (20-29%) or blasts in the blood; Auer rods; absence ...

https://en.wikipedia.org/wiki/Myelodysplastic_syndrome

A dosage of 90 mg/kg every 6 hours is suggested for infants and children diagnosed with neutropenia. Common side effects ... 1997). Febrile Neutropenia. Berlin, Heidelberg: Springer Berlin Heidelberg. doi:10.1007/978-3-642-60443-0. ISBN 978-3-540-61230 ... neutropenia (10%), and eosinophilia (10%) in adult patients. The combination of piperacillin-tazobactam with other antibiotics ...

https://en.wikipedia.org/wiki/Piperacillin

Autoimmune neutropenia. N Engl J Med. 1975; 293:748-793. 31. Stossel TP, Hartwig JH. Interactions of actin, myosin and a new ... Chronic neutropenia in childhood. Analysis of 16 cases and review of the literature. Am J Med. 1976; 61:849-861. 34. Hartwig JH ... Drug-induced immunologic neutropenia. Lancet. 1978; 1:1068-1072. 42. Brotschi EA, Hartwig JH, Stossel TP. The gelation of actin ... Therapy of neutropenia. In: Conn HF, ed. Current Therapy. Philadelphia: W.B. Saunders, 1977: 273-76. 17. Stossel TP. ...

https://en.wikipedia.org/wiki/Thomas_P._Stossel

Neutropenia patients are advised to avoid contact with people who are ill, monitor closely for signs of infection, and take ... "Neutropenia - MeSH - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-08-14. "Cytopenia Overview, Types - Cytopenia - ... Leukopenia - a deficiency of white blood cells, or leukocytes Neutropenia - a type of leukopenia, with a specific deficiency in ...

https://en.wikipedia.org/wiki/Cytopenia

Canine cyclic neutropenia is a cyclic blood disorder that is usually fatal to affected puppies. The disease is also referred to ... "Canine Cyclic Neutropenia". Collie Health Foundation. Archived from the original on 2008-05-14. Retrieved 2008-02-14. "The ...

https://en.wikipedia.org/wiki/Rough_Collie

Neutropenia, meaning a low neutrophil count, may occur as a response to drug treatment (especially chemotherapy) or in certain ... Neutropenia also occurs in many hematologic disorders, such as leukemia and myelodysplastic syndrome, and in a variety of ... 2011). p. 8. Atallah-Yunes, Suheil Albert; Ready, Audrey; Newburger, Peter E. (2019). "Benign ethnic neutropenia". Blood ... this is termed benign ethnic neutropenia. Very low neutrophil counts are associated with immunosuppression. When stimulated by ...

https://en.wikipedia.org/wiki/White_blood_cell_differential

HAX1 Neutropenia, severe congenital, autosomal recessive 4; 612541; G6PC3 Neutropenia, severe congenital, X-linked; 300299; WAS ... PNPLA2 Neutropenia, nonimmune chronic idiopathic, of adults; 607847; GFI1 Neutropenia, severe congenital, autosomal dominant 1 ... 202700; ELANE Neutropenia, severe congenital, autosomal dominant 2; 613107; GFI1 Neutropenia, severe congenital, autosomal ... FLCN Poikiloderma with neutropenia; 604173; C16orf57 Polycystic kidney and hepatic disease; 263200; FCYT Polycystic kidney ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

Toxicity: Allergic response & neutropenia. Mechanism of action: Recombinant form of human TNF receptor that binds TNF. Clinical ...

https://en.wikipedia.org/wiki/Biological_response_modifier

Neulastim (pegfilgrastim), for neutropenia. Neupogen (filgrastim), for neutropenia. Nutropin (somatropin), for growth hormone ...

https://en.wikipedia.org/wiki/Roche

An ANC less than 1500 cells/µL is defined as neutropenia and increases risk of infection. Neutropenia is the condition of a low ... Boxer, Laurence A. (2012). "How to approach neutropenia". Hematology. American Society of Hematology. Education Program. 2012: ...

https://en.wikipedia.org/wiki/Absolute_neutrophil_count

... s are used to detect bloodstream infections in febrile neutropenia, a common complication of chemotherapy in which ... Territo, M (July 2018). "Neutropenia - Hematology and Oncology". Merck Manuals Professional Edition. Archived from the original ...

https://en.wikipedia.org/wiki/Blood_culture

Common toxicities are neutropenia (. ...

https://en.wikipedia.org/wiki/Epirubicin

Klastersky, Jean A. (2014), "Prevention of Febrile Neutropenia", Febrile Neutropenia, Tarporley: Springer Healthcare Ltd., pp. ... A neutropenic fever, also called febrile neutropenia, is a fever in the absence of normal immune system function. Because of ... 2001). Textbook of febrile neutropenia. Martin Dunitz. ISBN 978-1-84184-033-8. OCLC 48195937. Grunau BE, Wiens MO, Brubacher JR ...

https://en.wikipedia.org/wiki/Fever

Neutropenia has also been reported. Hallmark diagnostic markers of PNP deficiency include hypouricemia, complete or near ...

https://en.wikipedia.org/wiki/Purine_nucleoside_phosphorylase_deficiency

Low retic is observed in infants treated with IUT and in those with HDN from anti-Kell Neutrophils - as Neutropenia is one of ... Koenig, J. M.; Christensen, R. D. (1989). "Neutropenia and thrombocytopenia in infants with Rh hemolytic disease". The Journal ... Lalezari, P; Nussbaum, M; Gelman, S; Spaet, T. H. (1960). "Neonatal neutropenia due to maternal isoimmunization". Blood. 15 (2 ... The hemolytic process can result in anemia, hyperbilirubinemia, neonatal thrombocytopenia, and neonatal neutropenia. With the ...

https://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn_(anti-Kell)

The opposite of neutrophilia is neutropenia. Neutrophils are the primary white blood cells that respond to a bacterial ...

https://en.wikipedia.org/wiki/Neutrophilia

Treatment is also aimed at the underlying cause of the neutropenia. One severe consequence of neutropenia is that it can ... Neutropenia can be acquired or intrinsic. A decrease in levels of neutrophils on lab tests is due to either decreased ... Like neutropenia, lymphocytopenia may be acquired or intrinsic and there are many causes. This is not a complete list. ... For example, the most common cause of acquired neutropenia is drug-induced, so an individual may have symptoms of medication ...

https://en.wikipedia.org/wiki/White_blood_cell

Neutropenia makes an individual highly susceptible to infections. It can also be the result of colonization by intracellular ... Low neutrophil counts are termed neutropenia. This can be congenital (developed at or before birth) or it can develop later, as ... Any ANC < 1500 cells / mm3 is considered neutropenia, but < 0.001) the phagocytic index Rubin-Bejerano I, Abeijon C, Magnelli P ... Neutropenia Information Absolute Neutrophil Count Calculator Neutrophil Trace Element Content and Distribution (Webarchive ...

https://en.wikipedia.org/wiki/Neutrophil

Neutrophils - as neutropenia is one of the complications of HDN, the neutrophil count should be checked. Thrombocytes - as ... It is possible for a newborn with this disease to have neutropenia and neonatal alloimmune thrombocytopenia as well. Hemolysis ... Koenig JM, Christensen RD (April 1989). "Neutropenia and thrombocytopenia in infants with Rh hemolytic disease". The Journal of ... Lalezari P, Nussbaum M, Gelman S, Spaet TH (February 1960). "Neonatal neutropenia due to maternal isoimmunization". Blood. 15 ( ...

https://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn

Low retic is observed in infants treated with IUT and in those with HDN from anti-Kell Neutrophils - as Neutropenia is one of ... Koenig, J. M.; Christensen, R. D. (1989). "Neutropenia and thrombocytopenia in infants with Rh hemolytic disease". The Journal ... Lalezari, P; Nussbaum, M; Gelman, S; Spaet, T. H. (1960). "Neonatal neutropenia due to maternal isoimmunization". Blood. 15 (2 ... rising bilirubin Prolonged hyperbilirubinemia Bilirubin Induced Neurological Dysfunction Cerebral Palsy Kernicterus Neutropenia ...

https://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn_(ABO)

Low retic is observed in infants treated with IUT and in those with HDN from anti-Kell Neutrophils - as neutropenia is one of ... Koenig, J. M.; Christensen, R. D. (1989). "Neutropenia and thrombocytopenia in infants with Rh hemolytic disease". The Journal ... Lalezari, P; Nussbaum, M; Gelman, S; Spaet, T. H. (1960). "Neonatal neutropenia due to maternal isoimmunization". Blood. 15 (2 ... The hemolytic process can result in anemia, hyperbilirubinemia, neonatal thrombocytopenia, and neonatal neutropenia. With the ...

https://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn_(anti-RhE)

The mechanism of neutropenia is complex. An increased platelet count occurs when inflammation is uncontrolled.[citation needed ...

https://en.wikipedia.org/wiki/Rheumatoid_arthritis

... neutropenia (40%; 34% grade 3/4), thrombocytopenia (15%; 11% grade 3/4), anemia (12%), and pyrexia and cough (10% each). More ...

https://en.wikipedia.org/wiki/Obinutuzumab

Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. Mutations in the ... Zeidler C, Welte K (April 2002). "Kostmann syndrome and severe congenital neutropenia". Semin. Hematol. 39 (2): 82-8. doi: ... "Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia". ... colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia". N. Engl ...

https://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor_receptor

Mutations in this gene are associated with cyclic neutropenia (CyN) and severe congenital neutropenia (SCN). At least 95 ... In 2019 study was confirmed that ELANE deletion does not cause neutropenia. In order to minimize damage to tissues, there are ... Mutations of the ELANE gene cause cyclic and severe congenital neutropenia, which is a failure of neutrophils to mature. ... GeneReviews/NCBI/NIH/UW entry on ELANE-Related Neutropenias Neutrophil+Elastase at the US National Library of Medicine Medical ...

https://en.wikipedia.org/wiki/Neutrophil_elastase

Neutrophils - as Neutropenia is one of the complications of HDN, the neutrophil count should be checked. Thrombocytes - as ... Koenig, J. M.; Christensen, R. D. (1989). "Neutropenia and thrombocytopenia in infants with Rh hemolytic disease". The Journal ... Lalezari, P; Nussbaum, M; Gelman, S; Spaet, T. H. (1960). "Neonatal neutropenia due to maternal isoimmunization". Blood. 15 (2 ... The hemolytic process can result in anemia, hyperbilirubinemia, neonatal thrombocytopenia, and neonatal neutropenia. With the ...

https://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn_(anti-Rhc)

At one end the affected individuals have only neutropenia and related complications but no other organ is affected. This is ... Most affected individuals have a classic form of the disease with severe congenital neutropenia and cardiovascular and/or ... January 2009). "A syndrome with congenital neutropenia and mutations in G6PC3". The New England Journal of Medicine. 360 (1): ... Mutations in this gene result in autosomal recessive severe congenital neutropenia. G6PC3 deficiency results in a phenotypic ...

https://en.wikipedia.org/wiki/G6PC3

Recovery phase of neutropenia or an acute infection. Obesity (cf. Nagareddy et al. (2014), Cell Metabolism, Vol. 19, pp 821-835 ... Neutropenia, Monocytosis, and Monocytopenia". In Hoffman, Ronald; Benz, Edward J.; Heslop, Helen; Silberstein, Leslie E.; Weitz ... chronic neutropenia and myeloproliferative disorders. Autoimmune diseases and vasculitis: systemic lupus erythematosus, ...

https://en.wikipedia.org/wiki/Monocytosis

What Is Neutropenia?. Neutropenia, pronounced noo-troh-PEE-nee-uh, is a decrease in the number of white blood cells. These ... How Can I Prevent Neutropenia?. There is not much you can do to prevent neutropenia from occurring, but you can decrease your ... How Do I Know if I Have Neutropenia?. Your doctor or nurse will tell you. Because neutropenia is common after receiving ... When Will I Be Most Likely to Have Neutropenia?. Neutropenia often occurs between 7 and 12 days after you receive chemotherapy ...

https://www.cdc.gov/cancer/preventinfections/neutropenia.htm

Cyclic neutropenia is a disorder that causes frequent infections and other health problems in affected individuals. Explore ... The episodes of neutropenia are apparent at birth or soon afterward. For most affected individuals, neutropenia recurs every 21 ... People with cyclic neutropenia have these health problems only during episodes of neutropenia. At times when their neutrophil ... A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia. ...

https://medlineplus.gov/genetics/condition/cyclic-neutropenia/

No increase in 30-day all-cause mortality was seen in patients with febrile neutropenia who were treated with cefepime, as ... In addition, the FDA meta-analysis included patient-level data from 35 trials, 7 of them on febrile neutropenia; the 2007 meta- ... Of the 88 trials examined in the FDA meta-analysis, 24 were in febrile neutropenia and 22 were in pneumonia. Ceftazidime was ... 2007;7:338-348), so the FDA decided to undertake a more thorough meta-analysis to determine if febrile neutropenia patients ...

http://www.medscape.com/viewarticle/711767

Neutropenia is when a person has a low level of neutrophils. Neutrophils are a type of white blood cell. All white blood cells ... Signs and symptoms of neutropenia. Neutropenia itself may not cause any symptoms. People usually find out they have neutropenia ... Neutropenia is when a person has a low level of neutrophils. Neutrophils are a type of white blood cell. All white blood cells ... Causes of neutropenia. Several things related to cancer and its treatment can cause a low level of neutrophils, including:. * ...

https://www.cancer.net/es/node/25053

Neutropenia doesnt cause obvious symptoms, so it alone probably wont prompt you to go to your doctor. Neutropenia is usually ... Neutropenia can make you more vulnerable to infections. When neutropenia is severe, even the normal bacteria from your mouth ... Neutropenia. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017.. *Neutropenia and risk for infection. ... Neutropenia (noo-troe-PEE-nee-uh) occurs when you have too few neutrophils, a type of white blood cells. While all white blood ...

https://www.mayoclinic.org/symptoms/neutropenia/basics/definition/SYM-20050854?p=1

NEUTROPENIA, Neutropenia, Neutropenias. Spanish. NEUTROPENIA, neutropenia (trastorno), neutropenia, neutropenia (concepto no ... Neutropenias, NEUTROPENIA, neutropenia (diagnosis), neutropenia, Neutropenia, Neutropenia NOS, Neutropenia, unspecified, ... Neutropenia [Disease/Finding], Neutropenia (disorder), Neutropenia (finding), Disorder characterized by neutropenia, ... activo), neutropenia - trastorno (trastorno), neutropenia - trastorno, trastorno neutropénico, Neutropenias, Neutropenia. ...

https://fpnotebook.com/hemeonc/Lab/NtrpnCs.htm

Cyclic neutropenia (CyN) and severe congenital neutropenia (SCN) are two main forms of congenital neutropenia. Genetic analysis ... Congenital neutropenia is a heterogeneous bone marrow failure syndrome characterized by a maturation arrest of myelopoesis at ... Cyclic neutropenia (CyN) and severe congenital neutropenia (SCN) are two main forms of congenital neutropenia. Genetic analysis ... Four novel ELANE mutations in patients with congenital neutropenia Pediatr Blood Cancer. 2011 Aug;57(2):332-5. doi: 10.1002/pbc ...

https://pubmed.ncbi.nlm.nih.gov/21425445/

Can you prevent neutropenia?. No specific prevention for neutropenia is known. However, the National Neutropenia Network ... There are four types of neutropenia:. Congenital. Congenital neutropenia is present at birth. Severe congenital neutropenia is ... Cyclic neutropenia is present at birth and causes neutrophil counts to vary in a 21-day cycle. A period of neutropenia may last ... What is neutropenia?. Neutropenia is a blood condition characterized by low levels of neutrophils, which are white blood cells ...

https://www.healthline.com/health/neutropenia

Test yourself on presentation, workup, and treatment for neutropenia-related conditions with this quick quiz. ... Neutropenia is a low level of neutrophils often associated with significant conditions. ... Cyclic neutropenia is characterized by periodic bouts of neutropenia associated with infection, followed by peripheral ... Infections are the most common form of acquired neutropenia. Viral infections often lead to mild or moderate neutropenia. ...

https://reference.medscape.com/viewarticle/888806_3

... in chronic neutropenia (CN) patients as monotherapy or concurrently with injectable granulocyte colony-stimulating factor (G- ... X4 Pharma Highlights New Data Supporting Mavorixafors Broad Potential In Chronic Neutropenia. Read full article. ... When assessed as monotherapy in participants with severe chronic neutropenia who were not being treated with G-CSF (n=6), a ... When assessed in participants with moderate or severe neutropenia despite being treated with G-CSF (n=8), 100% reached ...

https://finance.yahoo.com/news/x4-pharma-highlights-data-supporting-144949316.html

... highlighted drugs other than chemotherapy that may cause neutropenia in patients. ... Mortality for severe neutropenia is around 5%, but 20 years ago it was around 20%. Curtis explained that the belief is that ... Curtis also identified some of the drugs that most commonly cause neutropenia. He looked at some recent studies and created a ... However, there have been cases of people developing neutropenia as soon as 3 days after starting medication and as late as 10 ...

https://www.ajmc.com/view/diagnosing-nonchemotherapy-druginduced-neutropenia

... which in turn allows for a better understanding of the basis of the neutropenia. Many of the neutropenia disorders can be ... both primary congenital neutropenia and multifaceted syndromes associated with neutropenia. Pediatr Blood Cancer 2007;49:609- ... Current knowledge on the molecular pathogenesis of severe congenital neutropenia indicates that the clinical diagnosis includes ... A molecular classification of congenital neutropenia syndromes. Boxer, Laurence A.; Newburger, Peter E. ...

https://deepblue.lib.umich.edu/handle/2027.42/56167

Find nationwide Neutropenia expert witnesses providing testimony and expert opinion in a court of law, for plaintiff and ...

https://www.hgexperts.com/expert-witnesses-neutropenia

Brought to you by Merck & Co, Inc., Rahway, NJ, USA (known as MSD outside the US and Canada)-dedicated to using leading-edge science to save and improve lives around the world. Learn more about the Merck Manuals and our commitment to Global Medical Knowledge.. ...

https://www.merckmanuals.com/home/multimedia/quiz/neutropenia

2022 Genetic Support Network of ...

https://www.gsnv.org.au/support-group-category/neutropenia/

Assess risk in febrile neutropenia and appropriateness for outpatient management ... The medical course of cancer patients with fever and neutropenia: clinical identification of a low-risk subgroup at ... for serious complications of febrile neutropenia (including death, intensive care unit admission, confusion, cardiac ... collaboration to derive and validate a scoring system to identify low-risk patients for complications of febrile neutropenia. ...

https://qxmd.com/calculate/calculator_134/mascc-febrile-neutropenia-risk

Neutropenia Details. The National Neutropenia Network (NNN) and the SCNIR are the U.S.A. Patient connection..For more details ... The Neutropenia Support Association Inc. (founded 1989) is independent of the U.S. based National Neutropenia Network (NNN) and ... The current knowledge of severe congenital neutropenia (SCN) and multifaceted syndromes accompanied by neutropenia has been ... The Neutropenia Support Assoc. Inc. is greatly indebted to the late Dr. Laurence Boxer, Ann Arbor Michigan and Dr. David C. ...

https://neutropenia.ca/index.php/do-your-reseach/leukemia-bone-marrow-transplants/nci-study-launched-on-rare-inherited-bone-marrow-failure-disorders-cancer-risk?id=99:neutropenia-details&catid=7

febrile neutropenia workup. As of July 2012, CXRs were ordered according to physician preference, instead of according to ... need to consider a range of risk factors for the occurrence and consequences of febrile neutropenia (FN), defined as body ... Risk of Febrile Neutropenia Associated With Select Myelosuppressive Chemotherapy Regimens in a Large Community-Based Oncology ... colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas ...

https://jnccn.org/search?access=all&pageSize=10&q=%22febrile+neutropenia%22&sort=relevance

Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia. Matilde I. Conte,1 M. Cecilia Poli,2,3 ... Here, we describe a familial NKD case in which 2 siblings had a substantive NKD and neutropenia in the absence of other immune ... Here, we describe a case of biallelic loss of another CMG helicase component, GINS4, resulting in NKD with neutropenia. By ... In the proband (II.1) described in our study, as in GINS1 deficiency, neutropenia was corrected by treatment with G-CSF. Since ...

https://insight.jci.org/articles/view/154948

Severe congenital neutropenia (SCN) is a monogenic disorder. SCN patients are prone to recurrent life-threatening infections. ... mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat severe congenital neutropenia View in ...

https://www.mdc-berlin.de/research/publications/crisprcas9-mediated-elane-mutation-correction-hematopoietic-stem-and

... the chemotherapy regimen selected and therapeutic dose intensity used in treatment factor into the calculation of neutropenia ... The prevention and treatment of neutropenia and febrile neutropenia are important because they are associated with morbidity ... 2 Progression of neutropenia to febrile neutropenia, in which an individual develops a temperature of 38.3°C/101°F or higher or ... neutropenia rates are believed to be underreported. Observational studies report higher rates of neutropenia than randomized ...

https://www.cancertherapyadvisor.com/home/tools/fact-sheets/managing-neutropenia/

Transient neutropenia has been described in a few cases of arboviruses. However, prolonged and severe neutropenia (<500/mm3 ... Physicians should be wary of possible unusual presentation of dengue fever with prolonged neutropenia. Although such biological ... presented a transient fever with severe neutropenia (<500/mm3). Laboratory tests showed a mild hepatic cytolysis and ... of severe neutropenia with a short duration of neutropenia (median of 1 day). Authors showed that severe neutropenia was not ...

https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-017-2732-4

Rolvedon™ (eflapegrastim-xnst) is now available to decrease the incidence of infection, as manifested by febrile neutropenia, ... Findings from both trials showed that the primary endpoint of noninferiority in the duration of severe neutropenia between ... which evaluated the safety and efficacy of eflapegrastim in 643 early-stage breast cancer patients who had neutropenia due to ... receiving myelosuppressive anticancer drugs associated with clinically significant incidence of febrile neutropenia. ...

https://www.hematologyadvisor.com/home/topics/general-hematology/rolvedon-now-available-for-chemotherapy-induced-neutropenia/

Dive into the research topics of Early implementation of antifungal therapy in the management of febrile neutropenia is ... T1 - Early implementation of antifungal therapy in the management of febrile neutropenia is associated with favourable outcome ... Early implementation of antifungal therapy in the management of febrile neutropenia is associated with favourable outcome ... title = "Early implementation of antifungal therapy in the management of febrile neutropenia is associated with favourable ...

https://researchers.mq.edu.au/en/publications/early-implementation-of-antifungal-therapy-in-the-management-of-f

Overactive WASp in X-linked neutropenia leads to aberrant B-cell division and accelerated plasma cell generation Minghui, He ... Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal ...

https://www.arca.fiocruz.br/browse?type=subject&value=X-linked+neutropenia

The association of neutropenia and NK cell deficiency, which is unusual among primary immunodeficiencies and bone marrow ... We studied 5 patients from 4 kindreds, all of whom displayed intrauterine growth retardation, chronic neutropenia, and NK cell ... The association of neutropenia and NK cell deficiency, which is unusual among primary immunodeficiencies and bone marrow ... Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. ...

https://www.ovg.ox.ac.uk/publications/691320

Neutropenia/Agranulocytosis. Neutropenia (,1000/mm3) with myeloid hypoplasia has resulted from use of captopril. About half of ... The neutropenia has usually been detected within three months after captopril was started. Bone marrow examinations in patients ... Hematologic : Neutropenia/agranulocytosis has occurred (see WARNINGS). Cases of anemia, thrombocytopenia, and pancytopenia have ... While none of the over 750 patients in formal clinical trials of heart failure developed neutropenia, it has occurred during ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=af396e2c-198a-4082-a0a1-d4e673d32fec

Neutropenia is a decrease in circulating neutrophils in the nonmarginal pool, which constitutes 4-5% of total body neutrophil ... encoded search term (Neutropenia) and Neutropenia What to Read Next on Medscape ... Neutropenia Differential Diagnoses. Updated: Oct 31, 2022 * Author: Carly DeFaria, MD; Chief Editor: Emmanuel C Besa, MD more ... Neutropenia in 6 ethnic groups from the Caribbean and the U.S. Cancer. 2008 Aug 15. 113(4):854-60. [QxMD MEDLINE Link]. ...

https://emedicine.staging.medscape.com/article/204821-differential

neutropenia is an immunodeficiency. syndrome. characterized by recurrent major bacterial infections, severe congenital ... PubMed is a searchable database of medical literature and lists journal articles that discuss Severe congenital neutropenia X- ... neutropenia, and monocytopenia. It has been described in five males spanning three generations of one family. It is transmitted ...

https://www.rareprimarycarenews.com/rarediseases/severe-congenital-neutropenia-x-linked/

Test yourself on presentation, workup, and treatment for neutropenia-related conditions with this quick quiz. ... Neutropenia is a low level of neutrophils often associated with significant conditions. ... Mild neutropenia is present when the ANC is 1000-1500 cells/µL, moderate neutropenia is present with an ANC of 500-1000/µL, and ... Neutropenia is a decrease in circulating neutrophils in the nonmarginal pool, which constitutes 4%-5% of total body neutrophil ...

https://reference.staging.medscape.com/viewarticle/888806

November 4, 2009 (Philadelphia, Pennsylvania) - Despite concerns raised after a meta-analysis suggested that increased mortality is associated with cefepime use in patients with febrile neutropenia and other infections, a new, more extensive meta-analysis should lay that fear to rest, researchers reported here at the Infectious Diseases Society of America (IDSA) 47th Annual Meeting. (medscape.com)
We found no significant increase in death among cefepime-treated patients with febrile neutropenia, [compared with those treated with] comparator drugs, either in trial data or in patient-level data," stated Peter Kim, MD, from the US Food and Drug Administration (FDA). (medscape.com)
2007;7:338-348), so the FDA decided to undertake a more thorough meta-analysis to determine if febrile neutropenia patients treated with cefepime had higher mortality. (medscape.com)
Of the 88 trials examined in the FDA meta-analysis, 24 were in febrile neutropenia and 22 were in pneumonia. (medscape.com)
In the 24 febrile neutropenia trials, 30-day all-cause mortality was 6.5% and 5.6%, respectively. (medscape.com)
In the 7 febrile neutropenia trials with patient-level data, mortality rates were 7.9% and 6.5%, respectively. (medscape.com)
Dr. Kim said that the data suggested that mortality is lower with cefepime in the United States than in other countries, and that the patients who died in febrile neutropenia trials appeared to die of underlying causes or cancer. (medscape.com)
Cite this: Cefepime Does Not Increase Mortality in Patients With Febrile Neutropenia - Medscape - Nov 04, 2009. (medscape.com)
The Multinational Association for Supportive Care in Cancer (MASCC) Risk Index can be used to identify low-risk patients (score ≥ 21 points) for serious complications of febrile neutropenia (including death, intensive care unit admission, confusion, cardiac complications, respiratory failure, renal failure, hypotension, bleeding, and other serious medical complications). (qxmd.com)
The MASCC study was an international collaboration to derive and validate a scoring system to identify low-risk patients for complications of febrile neutropenia. (qxmd.com)
The MASCC Febrile Neutropenia Risk calculator is created by QxMD. (qxmd.com)
Background The optimal duration of antibiotic therapy for patients with febrile neutropenia (FN) remains unknown. (jnccn.org)
Introduction: Chemotherapy-induced febrile neutropenia is a medical emergency. (jnccn.org)
Febrile neutropenia (FN) induced by chemotherapy (ChT) arises until 6 weeks after the last cycle, usually between 5 and 10 days post-ChT. (jnccn.org)
1,2 Progression of neutropenia to febrile neutropenia, in which an individual develops a temperature of 38.3°C/101°F or higher or 38.0°C/100.4°F or higher for at least 1 hour, is considered a major dose-limiting toxicity. (cancertherapyadvisor.com)
The prevention and treatment of neutropenia and febrile neutropenia are important because they are associated with morbidity and mortality. (cancertherapyadvisor.com)
The mortality rate of patients hospitalized with febrile neutropenia ranges from 10% to more than 20% depending on comorbidities. (cancertherapyadvisor.com)
For example, a meta-analysis of patients who received adjuvant fluorouracil, epirubicin, cyclophosphamide (FEC)-docetaxel in the community stetting showed a febrile neutropenia rate of 30.6%, which is in contrast to the 11.2% reported in the RCT that evaluated FEC-docetaxel. (cancertherapyadvisor.com)
Rolvedon ™ (eflapegrastim-xnst) is now available to decrease the incidence of infection, as manifested by febrile neutropenia, in adults with nonmyeloid malignancies receiving myelosuppressive anticancer drugs associated with clinically significant incidence of febrile neutropenia. (hematologyadvisor.com)
Results: All patients who developed febrile neutropenia received broad-spectrum antibiotics. (edu.au)
Early empirical antifungal treatment was commenced with voriconazole (15 patients) or caspofungin (12 patients) if the febrile neutropenia did not resolve after 72h of antibiotic therapy, in conjunction with radiological changes consistent with possible fungal infection. (edu.au)
A double-blind comparison of empirical oral and intravenous antibiotic therapy for low-risk febrile patients with neutropenia during cancer chemotherapy. (medscape.com)
Background Numerous paediatric febrile neutropenia (FN) clinical decision rules (CDRs) have been derived. (edu.au)
IMSEAR at SEARO: Management of febrile neutropenia in childern. (who.int)
Faizal M A M, Goonasekera C D A, Thevanesam V. Management of febrile neutropenia in childern. (who.int)
Febrile neutropenia clinical guideline (adults) v1. (etypecoach.com)
Febrile neutropenia is defined as having a neutrophil count of less than 1. (etypecoach.com)
Comparative effectiveness of pegfilgrastim biosimilars vs originator for prevention of febrile neutropenia: A retrospective cohort study. (bvsalud.org)
To compare the risk of febrile neutropenia (FN) among users of pegfilgrastim biosimilars (pegfilgrastim-jmdb and pegfilgrastim-cbqv) and the originator product. (bvsalud.org)
In the DESTINY-Gastric01 trial, the rates of neutropenia were about 72%, with a considerable number having grade 3 or 4, and there was about a 5% rate of febrile neutropenia. (oncnursingnews.com)
I've seen neutropenia but not febrile neutropenia with trastuzumab deruxtecan. (oncnursingnews.com)
Sixteen dogs were treated at this dosage, and 3 experienced severe toxicity characterized by asymptomatic grade 4 neutropenia, febrile grade 4 neutropenia, and death. (oradellhh.com)
To shorten the duration and reduce the incidence of neutropenia, including accompanied by a febrile reaction in patients receiving chemotherapy with cytotoxic drugs, with non-myeloid malignant diseases. (mysalve.com)

People with this condition have recurrent episodes of neutropenia during which there is a shortage (deficiency) of neutrophils . (medlineplus.gov)
Neutropenia is when a person has a low level of neutrophils. (cancer.net)
Neutropenia (noo-troe-PEE-nee-uh) occurs when you have too few neutrophils, a type of white blood cells. (mayoclinic.org)
A single blood test showing low levels of neutrophils doesn't necessarily mean you have neutropenia. (mayoclinic.org)
Numerous factors may cause neutropenia through destruction, decreased production or abnormal storage of neutrophils. (mayoclinic.org)
Neutropenia is a blood condition characterized by low levels of neutrophils, which are white blood cells that protect your body from infections. (healthline.com)
With autoimmune neutropenia, your body makes antibodies that fight your neutrophils. (healthline.com)
These antibodies kill the neutrophils, causing neutropenia. (healthline.com)
Although chemotherapy is the most common cause of neutropenia in patients, there are other drugs that might cause a patient might develop an abnormally low count of neutrophils. (ajmc.com)
Neutropenia is a decrease in circulating neutrophils in the nonmarginal pool, which constitutes 4%-5% of total body neutrophil stores. (medscape.com)
Neutropenia is a decrease in circulating (ie, nonmarginal) neutrophils in the blood. (medscape.com)
Neutrophils play a vital role in protecting against infection, so the duration and severity of neutropenia directly correlate with the total incidence of all infections, including those that are life threatening. (medscape.com)
Neutropenia is the medical term for the condition, where the number of neutrophils in the body decreases to an abnormally low level. (healthhearty.com)
A rare kind of blood disorder is cyclic neutropenia, where the number of neutrophils reduces in a cyclical pattern. (healthhearty.com)
An increased destruction of neutrophils can be caused by cancer treatments, such as chemotherapy, and autoimmune conditions like autoimmune neutropenia. (healthhearty.com)
Neutropenia is a condition where a person has an abnormally low concentration of neutrophils. (cathybiase.com)
People who have neutropenia have a higher risk of getting serious infections because they do not have enough neutrophils to fight off invading and harmful bacteria, viruses and fungi. (cathybiase.com)
Neutropenia is a condition marked by a low level of neutrophils, a type of white blood cell. (nortonchildrens.com)
Cyclic neutropenia is a rare blood disorder characterized by recurrent episodes of abnormally low levels of neutrophils (a type of white blood cell ) in the body. (raremedicalnews.com)
Individuals with low levels of neutrophils (neutropenia) are highly susceptible to recurrent infections. (raremedicalnews.com)
If your blood is low in neutrophils, you have a type of leukopenia known as neutropenia. (etypecoach.com)
Filgrastim is used to treat neutropenia,[9] stimulating the bone marrow to increase production of neutrophils. (affinityimmuno.com)

Germeshausen M, Deerberg S, Peter Y, Reimer C, Kratz CP, Ballmaier M. The spectrum of ELANE mutations and their implications in severe congenital and cyclic neutropenia. (medlineplus.gov)
Neutrophil elastase in cyclic and severe congenital neutropenia. (medlineplus.gov)
Congenital neutropenia is a heterogeneous bone marrow failure syndrome characterized by a maturation arrest of myelopoesis at the promyelocyte/myelocyte stage. (nih.gov)
Cyclic neutropenia (CyN) and severe congenital neutropenia (SCN) are two main forms of congenital neutropenia. (nih.gov)
We investigated the prevalence of ELANE mutations in a group of 16 patients from 14 families with congenital neutropenia. (nih.gov)
Congenital neutropenia is present at birth. (healthline.com)
Severe congenital neutropenia is also called Kostmann syndrome. (healthline.com)
Severe congenital neutropenia can have serious symptoms. (healthline.com)
According to the U.S. National Library of Medicine , most people with severe congenital neutropenia have no family history of the condition. (healthline.com)
Having severe congenital neutropenia increases your risk for other conditions. (healthline.com)
According to the U.S. National Library of Medicine, about 40 percent of people with congenital neutropenia have decreased bone density. (healthline.com)
The current knowledge of severe congenital neutropenia (SCN) and multifaceted syndromes accompanied by neutropenia has been detailed in many published articles in major medical journals. (neutropenia.ca)
Severe congenital neutropenia (SCN) is a monogenic disorder. (mdc-berlin.de)
X-linked severe congenital neutropenia is an immunodeficiency syndrome characterized by recurrent major bacterial infections, severe congenital neutropenia, and monocytopenia. (rareprimarycarenews.com)
The first is congenital neutropenia. (finetunehealth.com)
In children and adults with severe chronic neutropenia (severe congenital, periodic and malignant neutropenia), the drug stably increases the number of peripheral blood neutrophilic granulocytes and reduces the incidence of infectious complications. (mysalve.com)
With prolonged therapy aimed at increasing the number of neutrophilic granulocytes, to reduce the frequency and duration of infectious complications in children and adults with severe congenital, periodic or malignant neutropenia (the absolute number of neutrophilic granulocytes is 500 in 1 mm 3 ) and with severe or recurring infections in the anamnesis. (mysalve.com)

There is not much you can do to prevent neutropenia from occurring, but you can decrease your risk for getting an infection while your white blood cell count is low. (cdc.gov)
People with severe or long-lasting neutropenia are most likely to develop an infection. (cancer.net)
People usually find out they have neutropenia from a blood test or when they get an infection. (cancer.net)
For people with neutropenia, even a minor infection can quickly become serious. (cancer.net)
If you have neutropenia, practice good personal hygiene to lower your risk of infection. (cancer.net)
If you have neutropenia, your doctor may recommend measures to lessen your risk of infection, such as staying up to date on vaccinations, washing your hands regularly and thoroughly, wearing a face mask, and avoiding large crowds and anyone with a cold or other contagious illness. (mayoclinic.org)
Having neutropenia increases your risk for many types of infection. (healthline.com)
Cyclic neutropenia is characterized by periodic bouts of neutropenia associated with infection, followed by peripheral neutrophil count recovery. (medscape.com)
Authors showed that severe neutropenia was not associated with an increased risk of superinfection (including nosocomial infection), nor dengue shock syndrome or dengue hemorrhagic fever [ 3 ]. (biomedcentral.com)
The risk for bacterial infection is related to both the severity and duration of the neutropenia. (medscape.com)
[ 3 ] Major causes of acquired neutropenia are infection, drugs (through direct toxicity or immune effects), and autoimmunity. (medscape.com)
If one is diagnosed with severe neutropenia, there is a good chance that they are in danger of an imminent infection. (finetunehealth.com)
Most children get neutropenia after fighting an infection. (nortonchildrens.com)
Neulasta is a colony-stimulating factor that encourages hemopoietic stem cells to produce white blood cells, avoiding the neutropenia and susceptibility to infection that was previously a serious problem with chemotherapy. (blogspot.com)
It aims to reduce the risk of infection in people with neutropenia (low number of white blood cells) who a. (bvsalud.org)

Even as far back as 40 years ago, it was recognized that patients can develop severe agranulocytosis, a severe form of neutropenia. (ajmc.com)
Obtain a detailed history in patients with neutropenia or agranulocytosis, with particular emphasis on medication use. (medscape.com)
The term agranulocytosis is used to describe a more severe subset of neutropenia. (medscape.com)
Periodic or cyclic neutropenia is considered to be a rare hematological disorder, characterized by a chronic rhythmic recurrence of severe neutropenia or agranulocytosis at approximately three-week intervals. (jamanetwork.com)

Autoimmune neutropenia is most common in infants and young children, with the average age of diagnosis between 7 and 9 months . (healthline.com)
The symptoms of autoimmune and idiopathic neutropenia include infections. (healthline.com)
This test checks for autoimmune neutropenia. (healthline.com)
Autoimmune neutropenia, caused by neutrophil-specific autoantibodies is a common phenomenon in autoimmune disorders such as Felty's syndrome and systemic lupus erythematosus. (nebraska.edu)
The pathobiology of the autoimmune neutropenia in Felty's syndrome and systemic lupus erythematosus is complex, and it could be a major cause of morbidity and mortality due to increased risk of sepsis. (nebraska.edu)
Recombinant human granulocyte colony-stimulating factor is a safe and effective therapeutic modality in management of autoimmune neutropenia associated with Felty's syndrome and systemic lupus erythematosus, which stimulates neutrophil production. (nebraska.edu)
Newman, KA & Akhtari, M 2011, ' Management of autoimmune neutropenia in Felty's syndrome and systemic lupus erythematosus ', Autoimmunity Reviews , vol. 10, no. 7, pp. 432-437. (nebraska.edu)
Background/purpose: connective tissue diseases, including systemic lupus erythematosus (sle), account for most cases of autoimmune neutropenia (ain). (etypecoach.com)

If you have neutropenia with a fever, your doctor may give you medications called white blood cell growth factors. (cancer.net)
The medical course of cancer patients with fever and neutropenia: clinical identification of a low-risk subgroup at presentation. (qxmd.com)
Physicians should be wary of possible unusual presentation of dengue fever with prolonged neutropenia. (biomedcentral.com)
500/mm 3 ) in the returned traveler is particularly evocative of malaria whereas typhoid fever causes relative neutropenia. (biomedcentral.com)
They concluded that neutropenia was more often related to dengue fever than other arboviruses such as chikungunya. (biomedcentral.com)
We report the case of a patient being hospitalized in France for a severe neutropenia lasting for more than 72 h due to a dengue fever. (biomedcentral.com)
Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update. (medscape.com)
Symptoms of cyclic neutropenia may include fever, a general feeling of ill health, and/or sores (ulcers) of the mucous membranes of the mouth. (raremedicalnews.com)
Fever and Neutropenia is a topic covered in the Johns Hopkins ABX Guide . (hopkinsguides.com)
Spacek, Lisa A. "Fever and Neutropenia. (hopkinsguides.com)
Johns Hopkins Guide , www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540221/all/Fever_and_Neutropenia. (hopkinsguides.com)
Spacek LA. Fever and Neutropenia. (hopkinsguides.com)
Complex aphthosis is also seen in rarer conditions such as MAGIC syndrome (mouth and genital ulcers, inflamed cartilage), PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis, and lymphadenopathy), and cyclical neutropenia (fever approximately every 3 weeks, oral ulcers, neutropenia). (logicalimages.com)
To develop an evidence-based guideline for the empiric management of pediatric fever and neutropenia (FN). (bvsalud.org)
The International Pediatric Fever and Neutropenia Guideline Panel is a multidisciplinary and multinational group composed of experts in pediatric oncology and infectious disease as well as a patient. (bvsalud.org)
Guideline for the Management of Fever and Neutropenia in Pediatric Patients With Cancer and Hematopoietic Cell Transplantation Recipients: 2023 Update. (chop.edu)
To update a clinical practice guideline (CPG) for the empiric management of fever and neutropenia (FN) in pediatric patients with cancer and hematopoietic cell transplantation recipients. (chop.edu)
The International Pediatric Fever and Neutropenia Guideline Panel reconvened to conduct the second update of this CPG. (chop.edu)

Biological tests revealed a severe neutropenia (450/mm 3 ) with lymphopenia (540/mm 3 ), a thrombocytopenia (100,000/mm 3 ) and elevated liver enzymes (2 times above the normal value). (biomedcentral.com)
Concurrent anemia, thrombocytopenia, and/or an abnormal result on a peripheral blood smear from a patient with neutropenia suggest an underlying hematologic disorder. (medscape.com)
We know that from lenalidomide also the toxicity profile, so we see neutropenia, we see thrombocytopenia but nothing special, nothing unexpected. (ecancer.org)

Neutropenia is common after receiving chemotherapy and increases your risk for infections. (cdc.gov)
Cyclic neutropenia is a disorder that causes frequent infections and other health problems in affected individuals. (medlineplus.gov)
Neutropenia makes it more difficult for the body to fight off pathogens such as bacteria and viruses, so people with cyclic neutropenia typically develop recurrent infections of the sinuses, respiratory tract, and skin. (medlineplus.gov)
People who have neutropenia have a higher risk of getting serious infections. (cancer.net)
Recommending antibiotics during longer periods of neutropenia to prevent infections. (cancer.net)
Neutropenia can make you more vulnerable to infections. (mayoclinic.org)
The neutropenia is moderate to severe, with a mortality rate of 15%-25%, and the syndrome presents in infancy, with recurrent infections, diarrhea, and difficulty in feeding. (medscape.com)
Infections are the most common form of acquired neutropenia. (medscape.com)
Viral infections often lead to mild or moderate neutropenia. (medscape.com)
The duration and severity of neutropenia directly correlate with the total incidence of all infections and of those infections that are life-threatening. (medscape.com)
Felty's syndrome is associated with neutropenia and splenomegaly in seropositive rheumatoid arthritis which can be severe and with recurrent bacterial infections. (nebraska.edu)
Neutropenia is a condition characterized by a low neutrophil count, which can increase the risk of infections. (healthhearty.com)
But in neutropenia, the number of these white blood cells reduces significantly, which can make the body more vulnerable to frequent infections. (healthhearty.com)
During times of neutropenia, it may be more difficult for the body to fight bacteria , viruses , and infections. (raremedicalnews.com)
The severity of the resulting infections can vary and are often similar to the severity of the neutropenia itself. (raremedicalnews.com)

For more on the etiology of neutropenia, read here . (medscape.com)
Neutropenia has a wide range of causes, both hereditary and acquired (see Etiology ). (medscape.com)
Drug induced neutropenia (likely mmf induced neutropenia) was considered the plausible etiology by. (etypecoach.com)
T-cell imbalance in neutropenia of uncertain etiology. (uchicago.edu)

Trabajo Fin de Máster Universitario en Urgencias y Emergencias Pediátricas (2018/19). (unia.es)

Neutropenia was the dose-limiting toxicity, with the nadir identified 7 days after treatment and resolving by 14 days after treatment. (oradellhh.com)

When assessed as monotherapy in participants with severe chronic neutropenia who were not being treated with G-CSF (n=6), a single dose of mavorixafor led to normalized ANC levels in all participants within 2 hours. (yahoo.com)
The Neutropenia Support Association Inc. (founded 1989) is independent of the U.S. based National Neutropenia Network (NNN) and the Severe Chronic Neutropenia International Registry (SCNIR). (neutropenia.ca)

People with cyclic neutropenia typically present as infants or children, but acquired forms in adulthood are noted. (medscape.com)

A population pharmacokinetic-pharmacodynamic (PK-PD) model was introduced to predict the development of docetaxel-induced neutropenia in Japanese patients with non-small cell lung cancer (NSCLC). (elsevier.com)
Conclusion: The developed model may facilitate the prediction and care of docetaxel-induced neutropenia. (elsevier.com)

Neutropenia symptoms can range from mild to severe. (healthline.com)
Neutropenia is classified as mild, moderate, or severe based on the absolute neutrophil count (ANC). (medscape.com)
Mild neutropenia is present when the ANC is 1000-1500 cells/µL, moderate neutropenia is present with an ANC of 500-1000/µL, and severe neutropenia refers to an ANC lower than 500 cells/µL. (medscape.com)
Mild neutropenia occurs when the ANC count drops below the fifteen hundred level, and yet is above the one thousand count mark. (finetunehealth.com)

There is also some evidence that neutropenia is a factor contributing to the severity of oesophagitis. (biomedcentral.com)
The treatment of neutropenia depends on its cause and severity. (cathybiase.com)
Depending on the cause and severity, neutropenia may not need treatment. (nortonchildrens.com)

The diversity of mutations and clinical outcomes for ELANE-associated neutropenia. (medlineplus.gov)
Información confiable y compasiva para personas con cáncer, sus familiares y sus cuidadores, de parte de expertos de la American Society of Clinical Oncology (la Sociedad Estadounidense de Oncología Clínica, ASCO por sus siglas en inglés), la voz de los médicos del cáncer y los profesionales oncológicos del mundo. (cancer.net)
XFOR ) announced new data from its Phase 1b trial evaluating the ability of its lead clinical candidate, mavorixafor, to increase the absolute neutrophil count (ANC) in chronic neutropenia (CN) patients as monotherapy or concurrently with injectable granulocyte colony-stimulating factor (G-CSF). (yahoo.com)
Although there is currently no consensus algorithm for determining an individual's risk for neutropenia, distinct risk levels are assigned to different chemotherapy regimens based on the reported rates of neutropenia during their respective clinical trials. (cancertherapyadvisor.com)
4 Therefore, some myelosuppressive therapies may carry a higher risk of inducing neutropenia than has been identified during clinical trials. (cancertherapyadvisor.com)
Purpose: Docetaxel is used to treat many cancers, and neutropenia is the dose-limiting factor for its clinical use. (elsevier.com)
CHS was first described over 60 years ago by Beguez-Cesar (1943) in three siblings bearing the main clinical features of neutropenia and abnormal granules in leukocytes. (medscape.com)
To reduce the duration of neutropenia and its clinical consequences in patients receiving myeloablative therapy with subsequent bone marrow transplantation. (mysalve.com)

Observational studies report higher rates of neutropenia than randomized controlled trials (RCTs). (cancertherapyadvisor.com)

Because neutropenia is common after receiving chemotherapy, your doctor may draw some blood to look for neutropenia. (cdc.gov)
Your doctor will schedule regular blood tests to look for neutropenia and other blood-related side effects of chemotherapy. (cancer.net)

Most cases of neutropenia can be treated with granulocyte-colony stimulating factors (G-CSF). (healthline.com)

Children with certain inherited types of neutropenia are treated with growth factor support. (nortonchildrens.com)

Even normal bacteria from the mouth and digestive tract can cause serious illness in children with neutropenia. (nortonchildrens.com)
Children with neutropenia due to a blood, bone marrow or immune disorder will be treated for their specific condition. (nortonchildrens.com)

How we diagnose and treat neutropenia in adults. (medscape.com)

Cyclic neutropenia is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. (medlineplus.gov)
Neutropenia is a disorder of the circulatory system. (finetunehealth.com)
Genetic testing: This may be done to see if there's an underlying hereditary condition, such as a bone marrow disorder, causing neutropenia. (nortonchildrens.com)

Neutropenia itself may not cause any symptoms. (cancer.net)
Neutropenia doesn't cause obvious symptoms, so it alone probably won't prompt you to go to your doctor. (mayoclinic.org)
What are the symptoms of neutropenia? (healthline.com)
The symptoms of cyclic neutropenia recur in 3-week cycles. (healthline.com)
Individuals with cyclic neutropenia can exhibit all or a few of the aforementioned symptoms, but only during the period when the neutrophil count is low. (healthhearty.com)
So, if you observe any of the symptoms mentioned above, then get the condition properly evaluated with the help of your physician to rule out the possibility of neutropenia and other diseases. (healthhearty.com)
The signs and symptoms of cyclic neutropenia usually appear at birth or shortly after. (raremedicalnews.com)
Individuals with cyclic neutropenia only have symptoms during times of neutropenia. (raremedicalnews.com)

We studied 5 patients from 4 kindreds, all of whom displayed intrauterine growth retardation, chronic neutropenia, and NK cell deficiency. (ox.ac.uk)
Autosomal recessive, partial GINS1 deficiency impairs DNA replication and underlies intra-uterine (and postnatal) growth retardation, chronic neutropenia, and NK cell deficiency. (ox.ac.uk)

Cyclic neutropenia is present at birth and causes neutrophil counts to vary in a 21-day cycle. (healthline.com)
On the other hand, serial neutrophil counts are taken, if cyclic neutropenia is suspected. (healthhearty.com)
The model-based simulation also showed that ALB and AAG negatively correlated with the development of neutropenia and that the time course of neutrophil counts was predictable. (elsevier.com)

Neutropenia was the principal toxicity and precluded dose escalation to levels greater than 750 mg/m 2 on the single-dosing (3-hour) schedule and 150 mg/m 2 /d x 5 (total dose, 750 mg/m 2 ) on the multiple-dosing schedule. (elsevier.com)

Leukopenia is closely related to neutropenia. (medscape.com)

When assessed in participants with moderate or severe neutropenia despite being treated with G-CSF (n=8), 100% reached normalized ANC levels. (yahoo.com)
Moderate neutropenia occurs between one thousand and five hundred ANC, and severe neutropenia is marked by any ANC below five hundred. (finetunehealth.com)

When neutropenia is severe, even the normal bacteria from your mouth and digestive tract can cause serious illness. (mayoclinic.org)

Curtis explained that the belief is that mortality has been reduced so drastically "because we have done a much better job of educating not only physicians, but patients themselves, about what to look for when they're on certain drugs that are particularly prone to causing neutropenia. (ajmc.com)

Half of people with cancer who are receiving chemotherapy have some level of neutropenia. (cancer.net)
https://www.cdc.gov/cancer/preventinfections/neutropenia.htm. (mayoclinic.org)
NCT02953340 ), which evaluated the safety and efficacy of eflapegrastim in 643 early-stage breast cancer patients who had neutropenia due to myelosuppressive cytotoxic chemotherapy. (hematologyadvisor.com)
Cancer patients who are receiving treatment can be at risk of neutropenia. (cathybiase.com)

Neutropenia, pronounced noo-troh-PEE-nee-uh, is a decrease in the number of white blood cells. (cdc.gov)
3 In addition, neutropenia may require a decrease in chemotherapy dose intensity, dose delays, or the use of alternative regimens that may be less efficacious. (cancertherapyadvisor.com)

In making a diagnosis of neutropenia, it's difficult because a lot of things can contribute to it," he explained. (ajmc.com)

The use of filgrastim preparations significantly reduces the frequency and duration of neutropenia in patients after chemotherapy with cytostatics, myeloablative therapy, followed by bone marrow transplantation. (mysalve.com)

This condition is characterized by recurrent episodes of neutropenia that recur every 14-35 days (most commonly around 21 days) and last between 3 and 5 days. (raremedicalnews.com)

Clozapine, neutropenia and prednisone test. (etypecoach.com)

Idiopathic neutropenia develops any time in life and can affect anyone. (healthline.com)
Idiopathic neutropenia affects people of all ages, but people over 70 are at higher risk. (healthline.com)
Idiopathic neutropenia usually develops during or shortly after another illness. (finetunehealth.com)

During severe neutropenia in the returned traveler, the absence of infectious complication is widely thought to be due to the really short duration of neutropenia. (biomedcentral.com)
Findings from both trials showed that the primary endpoint of noninferiority in the duration of severe neutropenia between eflapegrastim and pegfilgrastim was met. (hematologyadvisor.com)

Steroids in high risk neutropenic sepsis Safe ways to pay with Bitcoin, Paypal, WU, bank transfer via this safe exchange or by using Paybis, steroids neutropenia. (etypecoach.com)

Neutropenia is also a common side effect in people with leukemia and can also be caused by solid tumour malignancies if they infiltrate the bone marrow. (cathybiase.com)

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Diseases53

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

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Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity. (1/2974)

Itraconazole oral solution as prophylaxis for fungal infections in neutropenic patients with hematologic malignancies: a randomized, placebo-controlled, double-blind, multicenter trial. GIMEMA Infection Program. Gruppo Italiano Malattie Ematologiche dell' Adulto. (2/2974)

Randomized placebo-controlled trial of fluconazole prophylaxis for neutropenic cancer patients: benefit based on purpose and intensity of cytotoxic therapy. The Canadian Fluconazole Prophylaxis Study Group. (3/2974)

The evolution of antibiotic therapy for neutropenic patients. (4/2974)

Protein kinase C mediates experimental colitis in the rat. (5/2974)

A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq (nolatrexed dihydrochloride) given by 10-day oral administration. (6/2974)

Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer. (7/2974)

Pneumonia in febrile neutropenic patients and in bone marrow and blood stem-cell transplant recipients: use of high-resolution computed tomography. (8/2974)

Neutropenia

Agranulocytosis

Febrile Neutropenia

Chemotherapy-Induced Febrile Neutropenia

Fever

Granulocyte Colony-Stimulating Factor

Antineoplastic Combined Chemotherapy Protocols

Drug Administration Schedule

Taxoids

Paclitaxel

Infusions, Intravenous

Treatment Outcome

Camptothecin

Thrombocytopenia

Maximum Tolerated Dose

Neoplasms

Leukocyte Count

Deoxycytidine

Antineoplastic Agents, Phytogenic

Cisplatin

Antineoplastic Agents

Felty Syndrome

Leukocyte Elastase

Neutrophils

Fluorouracil

Mycoses

Leukopenia

Vinblastine

Hematologic Diseases

Dose-Response Relationship, Drug

Receptors, Granulocyte Colony-Stimulating Factor

Carboplatin

Fever of Unknown Origin

Survival Analysis

Doxorubicin

Cyclophosphamide

Organoplatinum Compounds

Leucovorin

Bacterial Infections

Opportunistic Infections

Disease-Free Survival

Topotecan

Lung Neoplasms

Hematologic Neoplasms

Survival Rate

Nausea

Etoposide

Epirubicin

Recombinant Proteins

Blood Cell Count

Immunocompromised Host

Salvage Therapy

Antimetabolites, Antineoplastic

Neoplasm Metastasis

Administration, Oral

Antifungal Agents

Area Under Curve

Bone Marrow

Carcinoma, Non-Small-Cell Lung

Oxonic Acid

Neoplasm Staging

Tegafur

Retrospective Studies

Combined Modality Therapy

Ifosfamide

Granulocytes

Aspergillosis

Epothilones

Neoplasm Recurrence, Local

Antibiotic Prophylaxis

Remission Induction

Anti-Bacterial Agents

Alopecia

Fungemia

Bacteremia

Drug Therapy, Combination

Vincristine

Breast Neoplasms

Prospective Studies

Stomatitis