Neuropeptides
Substance P
FMRFamide
Neuropeptide Y
Calcitonin Gene-Related Peptide
Vasoactive Intestinal Peptide
Receptors, Neuropeptide
Invertebrate Hormones
Galanin
Tachykinins
Brachyura
Hypothalamus
Neurosecretory Systems
Neurokinin A
Pituitary Adenylate Cyclase-Activating Polypeptide
Enkephalin, Methionine
Dynorphins
Pyrrolidonecarboxylic Acid
Agouti-Related Protein
Neurotransmitter Agents
Somatostatin
Neurokinin B
Gastrin-Releasing Peptide
Molting
Peptide PHI
Neurotensin
Neurogenic Inflammation
Aplysia
Secretogranin II
Pro-Opiomelanocortin
Neuroimmunomodulation
Enkephalins
Hypothalamic Hormones
Orexin Receptors
Vasotocin
Receptors, Neurokinin-1
Neurons
Bombesin
Arthropod Proteins
Receptors, Tachykinin
Endorphins
Oxytocin
Insect Hormones
Amino Acid Sequence
Corticotropin-Releasing Hormone
Cholecystokinin
Molecular Sequence Data
Receptors, Neuropeptide Y
Ganglia
Pituitary Hormones
Proprotein Convertase 2
Enkephalin, Leucine
Lymnaea
Arcuate Nucleus
Vasopressins
Neprilysin
Carboxypeptidase H
Secretory Vesicles
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Neuroendocrine Cells
Amidine-Lyases
Receptors, Vasoactive Intestinal Polypeptide, Type I
Receptors, Vasoactive Intestinal Peptide
Urocortins
beta-Endorphin
Receptors, Neurokinin-2
Ganglia, Invertebrate
Immunohistochemistry
Receptors, G-Protein-Coupled
Autonomic Pathways
Receptors, Catecholamine
Neurokinin-1 Receptor Antagonists
Peptides
alpha-MSH
Opioid Peptides
Feeding Behavior
Receptors, Vasoactive Intestinal Peptide, Type II
Ascaris suum
Cockroaches
Nerve Fibers
Rats, Sprague-Dawley
Proprotein Convertase 1
Brain
RNA, Messenger
Chromatography, High Pressure Liquid
Peptide Hormones
Hypothalamic Area, Lateral
Melanocyte-Stimulating Hormones
Tachyphylaxis
Kisspeptins
Hydra
Intracellular Signaling Peptides and Proteins
Brain Chemistry
Neurophysins
Nervous System
Gastrointestinal Hormones
Signal Transduction
Arginine Vasopressin
Peptide Fragments
Radioimmunoassay
Mass Spectrometry
Ubiquitin Thiolesterase
Isoindoles
Bradykinin
Receptors, Corticotropin-Releasing Hormone
Rats, Wistar
In Situ Hybridization
Receptors, Pituitary Hormone
Hydrozoa
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide
Hypothalamo-Hypophyseal System
Larva
Hormones
Leptin
Melanins
Ecdysteroids
Cells, Cultured
Appetite Stimulants
Receptors, Calcitonin Gene-Related Peptide
Nervous System Physiological Phenomena
Central Nervous System
Chromogranins
Neurosecretion
Octopamine
Thyrotropin-Releasing Hormone
Malpighian Tubules
Grasshoppers
Nerve Endings
Dose-Response Relationship, Drug
Receptors, Neurotransmitter
Pituitary Gland, Posterior
Locomotion
Chromogranin B
Narcolepsy
Secretin
Receptors, Neurokinin-3
Ghrelin
Guinea Pigs
Gene Expression Regulation
Nerve Tissue
Skin
Pituitary Gland
Receptors, Opioid
Suprachiasmatic Nucleus
Miotics
Sensory Receptor Cells
Base Sequence
Midline Thalamic Nuclei
Proprotein Convertases
Nephropidae
Gonadotropin-Releasing Hormone
Microdialysis
Secretory Pathway
Caenorhabditis elegans Proteins
Serotonin
Crustacea
Receptors, Leptin
Nerve Growth Factor
Pancreatic Polypeptide
Caenorhabditis elegans
Gene Expression
Protease Inhibitors
Mixed Function Oxygenases
Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development. (1/5789)
We have identified a novel gene in a gene trap screen that encodes a protein related to the DnaJ co-chaperone in E. coli. The gene, named Mrj (mammalian relative of DnaJ) was expressed throughout development in both the embryo and placenta. Within the placenta, expression was particularly high in trophoblast giant cells but moderate levels were also observed in trophoblast cells of the chorion at embryonic day 8.5, and later in the labyrinth which arises from the attachment of the chorion to the allantois (a process called chorioallantoic fusion). Insertion of the ROSAbetageo gene trap vector into the Mrj gene created a null allele. Homozygous Mrj mutants died at mid-gestation due to a failure of chorioallantoic fusion at embryonic day 8.5, which precluded formation of the mature placenta. At embryonic day 8.5, the chorion in mutants was morphologically normal and expressed the cell adhesion molecule beta4 integrin that is known to be required for chorioallantoic fusion. However, expression of the chorionic trophoblast-specific transcription factor genes Err2 and Gcm1 was significantly reduced. The mutants showed no abnormal phenotypes in other trophoblast cell types or in the embryo proper. This study indicates a previously unsuspected role for chaperone proteins in placental development and represents the first genetic analysis of DnaJ-related protein function in higher eukaryotes. Based on a survey of EST databases representing different mouse tissues and embryonic stages, there are 40 or more DnaJ-related genes in mammals. In addition to Mrj, at least two of these genes are also expressed in the developing mouse placenta. The specificity of the developmental defect in Mrj mutants suggests that each of these genes may have unique tissue and cellular activities. (+info)Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family. (2/5789)
We have identified a new member of the TGF-beta superfamily, CET-1, from Caenorhabditis elegans, which is expressed in the ventral nerve cord and other neurons. cet-1 null mutants have shortened bodies and male tail abnormal phenotype resembling sma mutants, suggesting cet-1, sma-2, sma-3 and sma-4 share a common pathway. Overexpression experiments demonstrated that cet-1 function requires wild-type sma genes. Interestingly, CET-1 appears to affect body length in a dose-dependent manner. Heterozygotes for cet-1 displayed body lengths ranging between null mutant and wild type, and overexpression of CET-1 in wild-type worms elongated body length close to lon mutants. In male sensory ray patterning, lack of cet-1 function results in ray fusions. Epistasis analysis revealed that mab-21 lies downstream and is negatively regulated by the cet-1/sma pathway in the male tail. Our results show that cet-1 controls diverse biological processes during C. elegans development probably through different target genes. (+info)Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. (3/5789)
The adenomatous polyposis coli (APC) tumour-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta (GSK-3beta), axin/conductin and betacatenin. Complex formation induces the rapid degradation of betacatenin. In colon carcinoma cells, loss of APC leads to the accumulation of betacatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1] [2]). Here, we report the identification and genomic structure of APC homologues. Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP domains, both of which are required for binding to conductin. Like APC, APC2 regulates the formation of active betacatenin-Tcf complexes, as demonstrated using transient transcriptional activation assays in APC -/- colon carcinoma cells. Human APC2 maps to chromosome 19p13.3. APC and APC2 may therefore have comparable functions in development and cancer. (+info)Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization. (4/5789)
The Drosophila Inscuteable protein acts as a key regulator of asymmetric cell division during the development of the nervous system [1] [2]. In neuroblasts, Inscuteable localizes into an apical cortical crescent during late interphase and most of mitosis. During mitosis, Inscuteable is required for the correct apical-basal orientation of the mitotic spindle and for the asymmetric segregation of the proteins Numb [3] [4] [5], Prospero [5] [6] [7] and Miranda [8] [9] into the basal daughter cell. When Inscuteable is ectopically expressed in epidermal cells, which normally orient their mitotic spindle parallel to the embryo surface, these cells reorient their mitotic spindle and divide perpendicularly to the surface [1]. Like the Inscuteable protein, the inscuteable RNA is asymmetrically localized [10]. We show here that inscuteable RNA localization is not required for Inscuteable protein localization. We found that a central 364 amino acid domain - the Inscuteable asymmetry domain - was necessary and sufficient for Inscuteable localization and function. Within this domain, a separate 100 amino acid region was required for asymmetric localization along the cortex, whereas a 158 amino acid region directed localization to the cell cortex. The same 158 amino acid fragment could localize asymmetrically when coexpressed with the full-length protein, however, and could bind to Inscuteable in vitro, suggesting that this domain may be involved in the self-association of Inscuteable in vivo. (+info)Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy. (5/5789)
Sensitivity to the pungent vanilloid, capsaicin, defines a subpopulation of primary sensory neurons that are mainly polymodal nociceptors. The recently cloned vanilloid receptor subtype 1 (VR1) is activated by capsaicin and noxious heat. Using combined in situ hybridization and histochemical methods, we have characterized in sensory ganglia the expression of VR1 mRNA. We show that this receptor is almost exclusively expressed by neurofilament-negative small- and medium-sized dorsal root ganglion cells. Within this population, VR1 mRNA is detected at widely varying levels in both the NGF receptor (trkA)-positive, peptide-producing cells that elicit neurogenic inflammation and the functionally less characterized glial cell line-derived neurotrophic factor-responsive cells that bind lectin Griffonia simplicifolia isolectin B4 (IB4). Cells without detectable levels of VR1 mRNA are found in both classes. A subpopulation of the IB4-binding cells that produce somatostatin has relatively low levels of VR1 mRNA. A previously uncharacterized population of very small cells that express the receptor tyrosine kinase (RET) and that do not label for trkA or IB4-binding has the highest relative levels of VR1 mRNA. The majority of small visceral sensory neurons of the nodose ganglion also express VR1 mRNA, in conjunction with the BDNF receptor trkB but not trkA. Axotomy results in the downregulation of VR1 mRNA in dorsal root ganglion cells. Our data emphasize the heterogeneity of VR1 mRNA expression by subclasses of small sensory neurons, and this may result in their differential sensitivity to chemical and noxious heat stimuli. Our results also indicate that peripherally derived trophic factors may regulate levels of VR1 mRNA. (+info)Reproducibility studies with 11C-DTBZ, a monoamine vesicular transporter inhibitor in healthy human subjects. (6/5789)
The reproducibility of (+/-)-alpha-[11C] dihydrotetrabenazine (DTBZ) measures in PET was studied in 10 healthy human subjects, aged 22-76 y. METHODS: The scan-to-scan variation of several measures used in PET data analysis was determined, including the radioactivity ratio (target-to-reference), plasma-input Logan total distribution volume (DV), plasma-input Logan Bmax/Kd and tissue-input Logan Bmax/Kd values. RESULTS: The radioactivity ratios, plasma-input Bmax/Kd and tissue-input Bmax/Kd all have higher reliability than plasma-input total DV values. In addition, measures using the occipital cortex as the reference region have higher reliability than the same measures using the cerebellum as the reference region. CONCLUSION: Our results show that DTBZ is a reliable PET tracer that provides reproducible in vivo measurement of striatal vesicular monoamine transporter density. In the selection of reference regions for DTBZ PET data analysis, caution must be exercised in circumstances when DTBZ binding in the occipital cortex or the cerebellum may be altered. (+info)Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites. (7/5789)
NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase family protein, is known to bind to C-terminal ends of N-methyl-D-aspartate receptor 2B (NR2B) through its PDZ (PSD-95/Dlg/ZO-1) domains. NE-dlg/SAP102 and NR2B colocalize at synaptic sites in cultured rat hippocampal neurons, and their expressions increase in parallel with the onset of synaptogenesis. We have identified that NE-dlg/SAP102 interacts with calmodulin in a Ca2+-dependent manner. The binding site for calmodulin has been determined to lie at the putative basic alpha-helix region located around the src homology 3 (SH3) domain of NE-dlg/SAP102. Using a surface plasmon resonance measurement system, we detected specific binding of recombinant NE-dlg/SAP102 to the immobilized calmodulin with a Kd value of 44 nM. However, the binding of Ca2+/calmodulin to NE-dlg/SAP102 did not modulate the interaction between PDZ domains of NE-dlg/SAP102 and the C-terminal end of rat NR2B. We have also identified that the region near the calmodulin binding site of NE-dlg/SAP102 interacts with the GUK-like domain of PSD-95/SAP90 by two-hybrid screening. Pull down assay revealed that NE-dlg/SAP102 can interact with PSD-95/SAP90 in the presence of both Ca2+ and calmodulin. These findings suggest that the Ca2+/calmodulin modulates interaction of neuronal membrane-associated guanylate kinase proteins and regulates clustering of neurotransmitter receptors at central synapses. (+info)Actions of a pair of identified cerebral-buccal interneurons (CBI-8/9) in Aplysia that contain the peptide myomodulin. (8/5789)
A combination of biocytin back-fills of the cerebral-buccal connectives and immunocytochemistry of the cerebral ganglion demonstrated that of the 13 bilateral pairs of cerebral-buccal interneurons in the cerebral ganglion, a subpopulation of 3 are immunopositive for the peptide myomodulin. The present paper describes the properties of two of these cells, which we have termed CBI-8 and CBI-9. CBI-8 and CBI-9 were found to be dye coupled and electrically coupled. The cells have virtually identical properties, and consequently we consider them to be "twin" pairs and refer to them as CBI-8/9. CBI-8/9 were identified by electrophysiological criteria and then labeled with dye. Labeled cells were found to be immunopositive for myomodulin, and, using high pressure liquid chromatography, the cells were shown to contain authentic myomodulin. CBI-8/9 were found to receive synaptic input after mechanical stimulation of the tentacles. They also received excitatory input from C-PR, a neuron involved in neck lengthening, and received a slow inhibitory input from CC5, a cell involved in neck shortening, suggesting that CBI-8/9 may be active during forward movements of the head or buccal mass. Firing of CBI-8 or CBI-9 resulted in the activation of a relatively small number of buccal neurons as evidenced by extracellular recordings from buccal nerves. Firing also produced local movements of the buccal mass, in particular a strong contraction of the I7 muscle, which mediates radula opening. CBI-8/9 were found to produce a slow depolarization and rhythmic activity of B48, the motor neuron for the I7 muscle. The data provide continuing evidence that the small population of cerebral buccal interneurons is composed of neurons that are highly diverse in their functional roles. CBI-8/9 may function as a type of premotor neuron, or perhaps as a peptidergic modulatory neuron, the functions of which are dependent on the coactivity of other neurons. (+info)Neurogenic inflammation is often characterized by a heightened immune response, increased production of cytokines, and activation of immune cells such as macrophages and microglia. This condition can lead to a range of symptoms including pain, swelling, redness, and loss of function in the affected area.
Neurogenic inflammation can be difficult to diagnose as it can mimic other conditions such as infection or autoimmune disorders. Treatment options for neurogenic inflammation vary depending on the underlying cause but may include immunosuppressive medications, anti-inflammatory drugs, and therapies aimed at reducing nerve damage and promoting healing.
In summary, neurogenic inflammation is a complex condition that can result from various forms of nervous system damage or injury. It is characterized by an exaggerated immune response, increased production of pro-inflammatory cytokines, and activation of immune cells. Accurate diagnosis and appropriate treatment are essential to prevent further nerve damage and promote healing.
Definition: Hyperphagia is a condition characterized by excessive hunger and overeating, often seen in individuals with certain medical or psychiatric conditions.
More Information
Hyperphagia can be caused by a variety of factors, including:
* Hormonal imbalances, such as low levels of leptin or high levels of ghrelin
* Certain medications, such as steroids and some antidepressants
* Medical conditions, such as diabetes, hypothyroidism, and polycystic ovary syndrome (PCOS)
* Psychiatric conditions, such as binge eating disorder and other eating disorders
* Sleep deprivation or disruptions in the body's circadian rhythms
Symptoms of hyperphagia may include:
* Increased hunger and desire to eat
* Overeating or consuming large amounts of food
* Difficulty controlling food intake
* Feeling anxious or irritable when unable to eat
* Weight gain or obesity
Treatment for hyperphagia typically involves addressing the underlying cause, such as hormonal imbalances or psychiatric conditions. This may involve medication, therapy, or lifestyle changes. In some cases, weight loss strategies and nutrition counseling may also be helpful.
It is important to note that hyperphagia can have serious health consequences, including obesity, type 2 diabetes, and other metabolic disorders. If you suspect you or someone you know may be experiencing hyperphagia, it is important to seek medical attention to determine the cause and develop an appropriate treatment plan.
There are several types of narcolepsy, including:
* Type 1 narcolepsy: This is the most common form of the disorder, and it is characterized by the presence of cataplexy and low levels of hypocretin-1, a neurotransmitter that helps regulate sleep and wakefulness.
* Type 2 narcolepsy: This form of narcolepsy is similar to type 1, but it does not involve cataplexy. Instead, people with type 2 narcolepsy may experience other symptoms such as memory loss, anxiety, and depression.
* Narcolepsy with cataplexy: This is a subtype of type 1 narcolepsy that is characterized by the presence of both cataplexy and low levels of hypocretin-1.
* Narcolepsy without cataplexy: This is a subtype of type 2 narcolepsy that is characterized by the absence of cataplexy and low levels of hypocretin-1.
There is no cure for narcolepsy, but medications such as stimulants, modafinil, and sodium oxybate can help manage symptoms. Behavioral interventions such as scheduled napping and exercise can also be helpful in managing the disorder.
1. Tracheitis: This is an inflammation of the trachea that can be caused by viral or bacterial infections, allergies, or other factors. Symptoms may include coughing, fever, and difficulty breathing.
2. Tracheal tumors: These are abnormal growths that can develop in the trachea, either benign or malignant. Symptoms may include a persistent cough, difficulty swallowing, and shortness of breath.
3. Tracheal narrowing (tracheal stenosis): This is a condition where the trachea becomes narrowed due to scarring or other factors, making it harder for air to pass through. Symptoms may include wheezing, coughing, and shortness of breath.
4. Tracheomalacia: This is a condition where the walls of the trachea become weakened and collapse, causing difficulty breathing and other symptoms.
5. Bronchiectasis: This is a condition where the airways are damaged and widened, leading to the accumulation of mucus and other debris. Symptoms may include coughing, wheezing, and difficulty breathing.
6. Tracheobronchial disorders: These are conditions that affect both the trachea and bronchi, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Symptoms may include wheezing, coughing, and difficulty breathing.
These are just a few examples of tracheal diseases, and there are many other conditions that can affect the trachea as well. Treatment for these diseases may vary depending on the specific condition and severity of symptoms, but may include medications, respiratory therapy, or surgery in some cases.
Neuropeptide
Neuropeptide FF
Neuropeptide K
Neuropeptide W
Neuropeptide receptor
Neuropeptide B
Neuropeptide Y
Neuropeptide S
Cortistatin (neuropeptide)
Neuropeptide VF precursor
GPCR neuropeptide receptor
Neuropeptide Y receptor
Neuropeptide FF receptor
Neuropeptide S receptor
Neuropeptide Y receptor Y2
Neuropeptide FF receptor 1
Neuropeptide Y receptor Y5
Neuropeptide Y receptor Y1
Pheromone biosynthesis activating neuropeptide
Neuropeptide FF receptor 2
Neuropeptide Y receptor Y6
Adrenorphin
SB-334867
Filorexant
JTC-801
Tachykinin receptor 1
Melanocyte-inhibiting factor
Galanin receptor
Progastrin
Grimace scale
Discovery of novel proline-based neuropeptide FF receptor antagonists | RTI
Synthesis and Biological Characterization of Cyclic Disulfide-Containing Peptide Analogs of the Multifunctional Opioid...
Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus | Garvan Institute of...
Neuropeptides control many physiological and endocrinological processes in animals, performing as - THE PRESENT STUDY AIMED TO...
"When BigLEN Met GPR171: A Tale of a Recently Deorphanized Neuropeptide" by Erin N. Bobeck, Jonathan H. Wardman et al.
Serval - Metabolic control of sexual function and growth: role of neuropeptide Y and leptin
Download Neuropeptide Y Protocols
Neuropeptide - Salon de Shakti
Evolution of neuropeptide signalling systems.
Methylmercury affects the expression of hypothalamic neuropeptides that control body weight in C57BL/6J mice<...
Details for:
Neuropeptides et neuromédiateurs /
› WHO HQ Library catalog
Proglumide - Wikipedia
Neuropeptide Gel Eye & More | Love Beauty Gabinety Kosmetyki Profesjonalnej Warszawa
Perricone MD Neuropeptide Deep Wrinkle Serum
Action of Ascorbic Acid on Corticotropin | Nature
Grown Alchemist Regenerating Night Cream: Neuro-Peptide & Violet Leaf Extract - Celeste Parfums
Aging exaggerates pulpal pain sensation by increasing the expression levels of nociceptive neuropeptides and inflammatory...
A D-amino acid-containing neuropeptide discovery funnel<...
Circular RNA CircHIPK3 Promotes Homeostasis of the Intestinal Epithelium by Reducing MicroRNA 29b Function
The orexin category of hypothalamic neuropeptides continues to be implicated in - Outlook on PI3K/AKT/mTOR inhibition
Possible relationship between reboxetine and neuropeptide Y (NPY) signalling in neuron cell culture | AVESİS
Neuropeptide Y is involved in the regulation of quiescence of hematopoietic stem cells | AVESİS
Flying To The Tune Of A Neuropeptide Receptor: "Exciting" Insights From Fruit Flies - Science Trends
Pheromone biosynthesis activating neuropeptide (PBAN) and color polymorphism: An immunochemical study in Spodoptera littoralis ...
Anti-nociceptive effects of dual neuropeptide antagonist therapy in mouse model of neuropathic and inflammatory pain
Do neuropeptides in the dorsal horn change if the dorsal root ganglion cell death that normally accompanies peripheral nerve...
Neuropeptide S reduces mouse aggressiveness in the resident/intruder test through selective activation of the neuropeptide S...
April 2014 - Fight Aging!
Immunosuppressive | GreenMedInfo | Adverse Pharmacological Action
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Neuronal2
- Neuropeptides are a diverse class of neuronal signalling molecules that regulate physiological processes and behaviour in animals. (scilifelab.se)
- Research in this laboratory focuses on the regulation of biosynthesis, processing, intracellular trafficking, and secretion of neuropeptides and peptide hormones in neuronal and endocrine cells with an emphasis on the cellular organization of these biological processes. (nih.gov)
Receptor5
- Synthesis and Biological Characterization of Cyclic Disulfide-Containing Peptide Analogs of the Multifunctional Opioid/Neuropeptide FF Receptor Agonists That Produce Long-Lasting and Nontolerant Antinociception. (iasp-pain.org)
- In a previously described chimeric peptide, we reported that the multifunctional opioid/neuropeptide FF (NPFF) receptor agonist (BN-9) produced antinociception for 1.5 h after supraspinal administration. (iasp-pain.org)
- Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis. (ox.ac.uk)
- We sequenced DNA from 32 human families contributing to a genetic linkage signal on chromosome 7p13-15 and observed significant overrepresentation of predicted deleterious low-frequency coding variants in NPSR1, the gene encoding neuropeptide S receptor 1, in cases (predominantly stage III/IV) versus controls (P = 7.8 × 10-4). (ox.ac.uk)
- 10. Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils. (nih.gov)
Peptide5
- Neuropeptide Y (NPY), a peptide neurotransmitter released by interneurons in the dentate gyrus, has important effects on mood, anxiety-related behaviour and learning and memory. (garvan.org.au)
- MeHg induced the expression of the anorexigenic neuropeptide pro-omiomelanocortin (Pomc) and the orexigenic peptide Agoutirelated peptide (Agrp) in a concentration-dependent manner, suggesting deregulation of mechanisms that control body weight. (elsevier.com)
- Neuropeptides and peptide hormones are synthesized from larger multivalent precursors, and the biosynthesis may be regulated at the transcriptional, post-transcriptional (RNA splicing), translational, or post-translational levels. (nih.gov)
- A recent major focus of the laboratory has been on the mechanisms by which neuropeptides, peptide hormones, and their processing enzymes are sorted at the trans-Golgi network and targeted to the regulated secretory pathway and post-Golgi transport of hormone containing vesicles to the release site. (nih.gov)
- 1. In order to examine the concentration of neuropeptide Y‐like immuno‐reactivity (NPY‐LI) and atrial natriuretic peptide (ANP) in the circulation in man, blood was sampled from the iliac vein, the inferior vena cava, the superior vena cava, the pulmonary artery and the femoral artery in 13 patients undergoing cardiac catheterization. (sahmri.org.au)
Receptors3
- This research looks at the molecular pharmacology of G protein-coupled receptors (GPCRs), including those that have neuropeptide ligands. (otago.ac.nz)
- Here, we review revolutionary insights into the evolution of neuropeptide signalling that have been obtained recently through comparative analysis of genome/transcriptome sequence data and by 'deorphanisation' of neuropeptide receptors. (scilifelab.se)
- The neuropeptide antagonist cyclosomatostatin abrogated the inhibitory effect of somatostatin on T cell infiltration, indicating that the effect of somatostatin is mediated via specific somatostatin receptors. (nih.gov)
Ligands1
- We postulate that family B neuropeptide signaling in brain and peripheral endocrine tissues mediated through ERK requires activation of NCS-Rapgef2, and that this signaling pathway, and therefore its downstream cellular effects, may be pharmacologically distinguished from those of other cAMP effectors, including PKA and Epac, activated by family B neuropeptide ligands. (nih.gov)
NPFF1
- The neuropeptide FF (NPFF) system has been implicated in a number of physiological processes including modulating the pharmacological activity of opioid analgesics and several other classes of drugs of abuse. (rti.org)
Chemokine1
- Somatostatin does not inhibit SDF-1alpha-induced T cell attachment to the collagen substrate, which indicates that this neuropeptide specifically inhibits the process of chemokine-induced T cell penetration and migration through the collagen. (nih.gov)
Expression3
- In this study, we investigated if MeHg is able to induce changes in the expression of key hypothalamic neuropeptides that regulate energy homeostasis. (elsevier.com)
- Moreover, MeHg affected the expression of hypothalamic neuropeptides that control food intake and body weight in a gender- and dose-dependent manner. (elsevier.com)
- 3. Expression of neuropeptides and other neuroendocrine markers in human phaeochromocytomas. (nih.gov)
Physiological2
- Neuropeptides control many physiological and endocrinological processes in animals, performing as neuroactive chemical substances inside the peripheral and central anxious systems. (woofahs.com)
- We are entering a new era in neuropeptide research where it has become feasible to compare the physiological roles of orthologous and paralogous neuropeptides in a wide range of phyla. (scilifelab.se)
Gene2
- Furthermore, two rounds of genome duplication gave rise to an expanded repertoire of neuropeptide signalling systems in the vertebrate lineage, enabling neofunctionalisation and/or subfunctionalisation, but with lineage-specific gene loss and/or additional gene or genome duplications generating complex patterns in the phylogenetic distribution of paralogous neuropeptide signalling systems. (scilifelab.se)
- 18. Association study of two functional single nucleotide polymorphisms of neuropeptide y gene with multiple sclerosis. (nih.gov)
Role1
- Neuropeptide Y (NPY) is a neurotransmitter known for increasing appetite and possibly having a role in alcohol preference and dependence. (nih.gov)
Search1
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Page2
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Things1
- Postal Service dealing rough download Neuropeptide Y Protocols things by war books in East Cleveland, Ohio. (rainer-brueck.de)
Study2
- The present study shows, for first time, that MeHg is able to induce changes in hypothalamic neuropeptides that regulate energy homeostasis, favoring an anorexigenic/catabolic profile. (elsevier.com)
- In the present study, sensory irritants are characterized by the stimulation of neuropeptide release from sensory nerves in the nasal mucosa, while pulmonary irritants are characterized by recruitment of PMN into bronchoalveolar airspaces, elevation of breathing frequency, and neuropeptide release from sensory fibers innervating the epithelium of the conducting airways. (cdc.gov)
Secretion of neuropeptides2
- Both the enteric nervous system and the central nervous system can amplify or modulate the aspects of intestinal inflammation through secretion of neuropeptides or small molecules. (medscape.com)
- Research in this laboratory focuses on the regulation of biosynthesis, processing, intracellular trafficking, and secretion of neuropeptides and peptide hormones in neuronal and endocrine cells with an emphasis on the cellular organization of these biological processes. (nih.gov)
Crustacean5
- For example, the process of neurosecretion was first formally demonstrated in the crustacean X-organ-sinus gland system, and the first fully characterized invertebrate neuropeptide was from a shrimp. (nih.gov)
- Here, we review the basic biology of crustacean neuropeptides, discuss methodologies currently driving their discovery, provide an overview of the known families, and summarize recent data on their control of physiology and behavior. (nih.gov)
- A multi-scale strategy for discovery of novel endogenous neuropeptides in the crustacean nervous system. (nih.gov)
- Crustacean neuropeptides: structures, functions and comparative aspects. (nih.gov)
- Identification of putative crustacean neuropeptides using in silico analyses of publicly accessible expressed sequence tags. (nih.gov)
Receptor1
- 10. Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils. (nih.gov)
Inflammation1
- Summary Although the available data suggest an important role for neuropeptides in the pathophysiology of intestinal inflammation, there does yet not appear to be a function that can be taken as established for any of these molecules. (medscape.com)
Mechanisms2
- Clarification of the molecular mechanisms of action of neuropeptides and on immune and inflammatory reactions will likely yield new treatment options in the future. (medscape.com)
- A recent major focus of the laboratory has been on the mechanisms by which neuropeptides, peptide hormones, and their processing enzymes are sorted at the trans-Golgi network and targeted to the regulated secretory pathway and post-Golgi transport of hormone containing vesicles to the release site. (nih.gov)
Role3
- The purpose of this study is to present recent data on the role that neuropeptides play in the pathophysiology of IBD. (medscape.com)
- Neuropeptide Y (NPY) is a neurotransmitter known for increasing appetite and possibly having a role in alcohol preference and dependence. (nih.gov)
- Ancestral Role of Ecdysis-Related Neuropeptides in Animal Life Cycle Transitions. (bvsalud.org)
Functions1
- Recently discovered functions of each of these neuropeptides with a discussion of implications of the data for therapy are reviewed. (medscape.com)