Innervated clusters of NEUROEPITHELIAL CELLS found in the LUNGS. They act as airway OXYGEN sensors, releasing regulatory PEPTIDES and SEROTONIN in response to HYPOXIA.
Cells with the capacity to take up and decarboxylate the amine precursors DIHYDROXYPHENYLALANINE or 5-HYDROXYTRYPTOPHAN. This is a property of endocrine cells of neural and non-neural origin. APUDOMA is a general term collectively applied to tumors associated with APUD cells.
Cells of epithelial origin possessing specialized sensory functions. They include cells that are found in the TASTE BUDS; OLFACTORY MUCOSA; COCHLEA; and NEUROEPITHELIAL BODIES.
A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.
Neoplasms composed of neuroepithelial cells, which have the capacity to differentiate into NEURONS, oligodendrocytes, and ASTROCYTES. The majority of craniospinal tumors are of neuroepithelial origin. (From Dev Biol 1998 Aug 1;200(1):1-5)
Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
In invertebrate zoology, a lateral lobe of the FOREBRAIN in certain ARTHROPODS. In vertebrate zoology, either of the corpora bigemina of non-mammalian VERTEBRATES. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1329)

Na(+)/K(+) -ATPase as a marker for detecting pulmonary sensory receptors. (1/12)

Pulmonary vagal afferents provide some of the most important breathing control inputs to the respiratory center. However, the structure of vagal receptors is not yet well known. Lack of an available and effective method to identify pulmonary receptors is the major limiting factor. Here we describe a new approach using confocal microscopy to examine the structure of immunohistochemically stained airway receptors by using Na(+)/K(+)-ATPase as a marker. This method permits detailed observation of pulmonary receptor structures and their relationship to target tissue in the rabbit. The parent axon has multiple branches that supply the receptor structure. Each structure has multiple endings that form leaf-like terminals. This technique permits examining pulmonary receptor structures in detail, and should assist in identifying the morphology of the receptors and the mechanisms of receptor activation.  (+info)

An overview of vagal airway receptors. (2/12)

Breathing is critically depending on a variety of sensory feedbacks from multiple sources for its optimal performance. The sensory information from the lung and airways probably provides one of the most important feedbacks to adjust the respiratory controller to generate optimal breathing movements. Since Breuer and Hering made the seminal report regarding role of the vagus nerve in control of breathing in 1868, airway sensory receptors have been a subject for intensive and extensive studies. After more than a century investigation, our knowledge accumulates immensely, however, our understanding of the nature of these sensory receptors is still far from complete. This brief review provides an overview on this topic.  (+info)

Functional facets of the pulmonary neuroendocrine system. (3/12)

Pulmonary neuroendocrine cells (PNECs) have been around for 60 years in the scientific literature, although phylogenetically they are ancient. Their traditionally ascribed functions include chemoreception and regulation of lung maturation and growth. There is recent evidence that neuroendocrine (NE) differentiation in the lung is regulated by genes and pathways that are conserved in the development of the nervous system from Drosophila to humans (such as achaete-scute homolog-1), or implicated in the carcinogenesis of the nervous or NE system (such as the retinoblastoma tumor suppressor gene). In addition, complex neural networks are in place to regulate chemosensory and other functions. Even solitary PNECs appear to be innervated. For the first time ever, we have mouse models for lung NE carcinomas, including the most common and virulent small cell lung carcinoma. Moreover, PNECs may be important for inflammatory responses, and pivotal for lung stem cell niches. These discoveries signify an exciting new era for PNECs and are likely to have therapeutic and diagnostic applications.  (+info)

Pulmonary neuroendocrine cells, airway innervation, and smooth muscle are altered in Cftr null mice. (4/12)

The amine- and peptide-producing pulmonary neuroendocrine cells (PNEC) are widely distributed within the airway mucosa of mammalian lung as solitary cells and innervated clusters, neuroepithelial bodies (NEB), which function as airway O2 sensors. These cells express Cftr and hence could play a role in the pathophysiology of cystic fibrosis (CF) lung disease. We performed confocal microscopy and morphometric analysis on lung sections from Cftr-/- (null), Cftr+/+, and Cftr+/- (control) mice at developmental stages E20, P5, P9, and P30 to determine the distribution, frequency, and innervation of PNEC/NEB, innervation and cell mass of airway smooth muscle, and neuromuscular junctions using synaptic vesicle protein 2, smooth muscle actin, and synaptophysin markers, respectively. The mean number of PNEC/NEB in Cftr-/- mice was significantly reduced compared with control mice at E20, whereas comparable or increased numbers were observed postnatally. NEB cells in Cftr null mice showed a significant reduction in intracorpuscular nerve endings compared with control mice, which is consistent with an intrinsic abnormality of the PNEC system. The airways of Cftr-/- mice showed reduced density (approximately 20-30%) of smooth muscle innervation, decreased mean airway smooth muscle mass (approximately 35%), and reduced density (approximately 20%) of nerve endings compared with control mice. We conclude that the airways of Cftr-/- mice exhibit heretofore unappreciated structural alterations affecting cellular and neural components of the PNEC system and airway smooth muscle and its innervation resulting in blunted O2 sensing and reduced airway tonus. Cftr could play a role in the development of the PNEC system, lung innervation, and airway smooth muscle.  (+info)

Characterization of slowly inactivating KV{alpha} current in rabbit pulmonary neuroepithelial bodies: effects of hypoxia and nicotine. (5/12)

Pulmonary neuroepithelial bodies (NEB) form innervated cell clusters that express voltage-activated currents and function as airway O(2) sensors. We investigated A-type K(+) currents in NEB cells using neonatal rabbit lung slice preparation. The whole cell K(+) current was slowly inactivating with activation threshold of approximately -30 mV. This current was blocked approximately 27% by blood-depressing substance I (BDS-I; 3 microM), a selective blocker of Kv3.4 subunit, and reduced approximately 20% by tetraethylammonium (TEA; 100 microM). The BDS-I-sensitive component had an average peak value of 189 +/- 14 pA and showed fast inactivation kinetics that could be fitted by one-component exponential function with a time constant of (tau1) 77 +/- 10 ms. This Kv slowly inactivating current was also blocked by heteropodatoxin-2 (HpTx-2; 0.2 microM), a blocker of Kv4 subunit. The HpTx-2-sensitive current had an average peak value of 234 +/- 23 pA with a time constant (tau) 82 +/- 11 ms. Hypoxia (Po(2) = 15-20 mmHg) inhibited the slowly inactivating K(+) current by approximately 47%, during voltage steps from -30 to +30 mV, and no further inhibition occurred when TEA was combined with hypoxia. Nicotine at concentrations of 50 and 100 microM suppressed the slowly inactivating K(+) current by approximately 24 and approximately 40%, respectively. This suppression was not reversed by mecamylamine suggesting a direct effect of nicotine on these K(+) channels. In situ hybridization experiments detected expression of mRNAs for Kv3.4 and Kv4.3 subunits, while double-label immunofluorescence confirmed membrane localization of respective channel proteins in NEB cells. These studies suggest that the hypoxia-sensitive current in NEB cells is carried by slowly inactivating A-type K(+) channels, which underlie their oxygen-sensitive potassium currents, and that exposure to nicotine may directly affect their function, contributing to smoking-related lung disease.  (+info)

Functional live cell imaging of the pulmonary neuroepithelial body microenvironment. (6/12)

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Purinergic signaling in the pulmonary neuroepithelial body microenvironment unraveled by live cell imaging. (7/12)

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Recruitment of GABA(A) receptors in chemoreceptor pulmonary neuroepithelial bodies by prenatal nicotine exposure in monkey lung. (8/12)

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Neuroepithelial bodies (NEBs) are clusters of neuroepithelial cells that are found in the airway epithelium, primarily in the intrapulmonary airways. These cells are capable of detecting chemical irritants and mechanical distortion within the airways and play a role in the regulation of breathing. NEBs contain chemoreceptors that respond to changes in oxygen and carbon dioxide levels, as well as other chemicals, and can stimulate neural reflexes that lead to changes in breathing pattern and depth. They are also thought to play a role in the development and maintenance of the airway epithelium. NEBs have been implicated in various respiratory disorders, including chronic obstructive pulmonary disease (COPD) and asthma.

APUD cells are a type of neuroendocrine cell that originated from the neural crest and are widely distributed throughout the body. The term "APUD" is an acronym for "Amine Precursor Uptake and Decarboxylation," which describes the ability of these cells to take up and decarboxylate amino acid precursors to produce biologically active amines, such as serotonin, histamine, and catecholamines.

APUD cells are capable of synthesizing, storing, and releasing hormones or neurotransmitters in response to various stimuli. They can be found in several endocrine and neural tissues, including the thyroid gland, adrenal medulla, pituitary gland, pancreas, lungs, and gastrointestinal tract.

In the gastrointestinal tract, APUD cells are often referred to as enterochromaffin cells or Kulchitsky cells. They play a crucial role in regulating gut motility, secretion, and blood flow through the release of hormones such as serotonin, gastrin, and somatostatin.

It's worth noting that the APUD cell concept has been largely replaced by the more comprehensive neuroendocrine system concept, which encompasses a broader range of cells with neurosecretory functions.

Neuroepithelial cells are stem cells that line the developing central nervous system (CNS) in embryos. These cells have the ability to differentiate into various cell types, including neurons and glial cells, which make up the brain and spinal cord. Neuroepithelial cells form a pseudostratified epithelium, meaning that the nuclei of the cells are at varying heights within the cell layer, giving it a striped appearance. These cells play a crucial role in the development and growth of the CNS.

Neurosecretory systems are specialized components of the nervous system that produce and release chemical messengers called neurohormones. These neurohormones are released into the bloodstream and can have endocrine effects on various target organs in the body. The cells that make up neurosecretory systems, known as neurosecretory cells, are found in specific regions of the brain, such as the hypothalamus, and in peripheral nerves.

Neurosecretory systems play a critical role in regulating many physiological processes, including fluid and electrolyte balance, stress responses, growth and development, reproductive functions, and behavior. The neurohormones released by these systems can act synergistically or antagonistically to maintain homeostasis and coordinate the body's response to internal and external stimuli.

Neurosecretory cells are characterized by their ability to synthesize and store neurohormones in secretory granules, which are released upon stimulation. The release of neurohormones can be triggered by a variety of signals, including neural impulses, hormonal changes, and other physiological cues. Once released into the bloodstream, neurohormones can travel to distant target organs, where they bind to specific receptors and elicit a range of responses.

Overall, neurosecretory systems are an essential component of the neuroendocrine system, which plays a critical role in regulating many aspects of human physiology and behavior.

Neuroepithelial neoplasms are a type of tumor that arises from the neuroepithelium, which is the tissue in the developing embryo that gives rise to the nervous system. These tumors can occur anywhere along the nervous system, including the brain and spinal cord (central nervous system) or the peripheral nerves.

Neuroepithelial neoplasms can be benign or malignant, and they can vary widely in their behavior and prognosis. Some common types of neuroepithelial neoplasms include:

1. Astrocytomas: These are tumors that arise from astrocytes, a type of star-shaped glial cell in the brain. Astrocytomas can be low-grade (slow-growing) or high-grade (fast-growing), and they can occur in different parts of the brain.
2. Oligodendrogliomas: These are tumors that arise from oligodendrocytes, a type of glial cell that provides support and insulation to nerve cells in the brain. Oligodendrogliomas are typically low-grade and slow-growing.
3. Ependymomas: These are tumors that arise from the ependyma, which is the tissue that lines the ventricles (fluid-filled spaces) in the brain and the spinal cord canal. Ependymomas can be benign or malignant, and they can occur in the brain or the spinal cord.
4. Medulloblastomas: These are fast-growing tumors that arise from primitive neuroectodermal cells in the cerebellum (the part of the brain that controls balance and coordination). Medulloblastomas are highly malignant and can spread to other parts of the brain and spinal cord.
5. Glioblastomas: These are the most common and aggressive type of primary brain tumor. They arise from astrocytes and can grow rapidly, invading surrounding brain tissue.

Neuroepithelial neoplasms are typically treated with surgery, radiation therapy, and chemotherapy, depending on the type and location of the tumor. The prognosis varies widely depending on the specific type and stage of the tumor.

Chemoreceptor cells are specialized sensory neurons that detect and respond to chemical changes in the internal or external environment. They play a crucial role in maintaining homeostasis within the body by converting chemical signals into electrical impulses, which are then transmitted to the central nervous system for further processing and response.

There are two main types of chemoreceptor cells:

1. Oxygen Chemoreceptors: These cells are located in the carotid bodies near the bifurcation of the common carotid artery and in the aortic bodies close to the aortic arch. They monitor the levels of oxygen, carbon dioxide, and pH in the blood and respond to decreases in oxygen concentration or increases in carbon dioxide and hydrogen ions (indicating acidity) by increasing their firing rate. This signals the brain to increase respiratory rate and depth, thereby restoring normal oxygen levels.

2. Taste Cells: These chemoreceptor cells are found within the taste buds of the tongue and other areas of the oral cavity. They detect specific tastes (salty, sour, sweet, bitter, and umami) by interacting with molecules from food. When a tastant binds to receptors on the surface of a taste cell, it triggers a series of intracellular signaling events that ultimately lead to the generation of an action potential. This information is then relayed to the brain, where it is interpreted as taste sensation.

In summary, chemoreceptor cells are essential for maintaining physiological balance by detecting and responding to chemical stimuli in the body. They play a critical role in regulating vital functions such as respiration and digestion.

A lung is a pair of spongy, elastic organs in the chest that work together to enable breathing. They are responsible for taking in oxygen and expelling carbon dioxide through the process of respiration. The left lung has two lobes, while the right lung has three lobes. The lungs are protected by the ribcage and are covered by a double-layered membrane called the pleura. The trachea divides into two bronchi, which further divide into smaller bronchioles, leading to millions of tiny air sacs called alveoli, where the exchange of gases occurs.

Respiratory mucosa refers to the mucous membrane that lines the respiratory tract, including the nose, throat, bronchi, and lungs. It is a specialized type of tissue that is composed of epithelial cells, goblet cells, and glands that produce mucus, which helps to trap inhaled particles such as dust, allergens, and pathogens.

The respiratory mucosa also contains cilia, tiny hair-like structures that move rhythmically to help propel the mucus and trapped particles out of the airways and into the upper part of the throat, where they can be swallowed or coughed up. This defense mechanism is known as the mucociliary clearance system.

In addition to its role in protecting the respiratory tract from harmful substances, the respiratory mucosa also plays a crucial role in immune function by containing various types of immune cells that help to detect and respond to pathogens and other threats.

The optic lobe in non-mammals refers to a specific region of the brain that is responsible for processing visual information. It is a part of the protocerebrum in the insect brain and is analogous to the mammalian visual cortex. The optic lobes receive input directly from the eyes via the optic nerves and are involved in the interpretation and integration of visual stimuli, enabling non-mammals to perceive and respond to their environment. In some invertebrates, like insects, the optic lobe is further divided into subregions, including the lamina, medulla, and lobula, each with distinct functions in visual processing.

Lauweryns JM, Cokelaere J, Theunynck P (April 1973). "Serotonin producing neuroepithelial bodies in rabbit respiratory mucosa ... I. Studies of isolated neuroepithelial bodies". Experimental Lung Research. 3 (3-4): 349-377. doi:10.3109/01902148209069663. ... contains specialized epithelial cells that occur as solitary cells or as clusters called neuroepithelial bodies or bronchial ... "Morphological and cytochemical characterization of neuroepithelial bodies in fetal rabbit lung. ...
Specialized epithelial cells (neuroepithelial bodies) that release serotonin have been suggested to contribute to hypoxic ... Lauweryns, Joseph M.; Cokelaere, Marnix; Theunynck, Paul (1973). "Serotonin Producing Neuroepithelial Bodies in Rabbit ...
Van Lommel, A (June 2001). "Pulmonary neuroendocrine cells (PNEC) and neuroepithelial bodies (NEB): chemoreceptors and ... The lungs of birds are relatively small, but are connected to 8 or 9 air sacs that extend through much of the body, and are in ... The lungs are supplied with the largest lymphatic drainage system of any other organ in the body. Each lung is surrounded by a ... Lung cancer can either arise directly from lung tissue or as a result of metastasis from another part of the body. There are ...
This is the case because their body is not able to recover as quickly, as it would for a child who has had one seizure before. ... Dysembryoplastic neuroepithelial tumour (DNT, DNET) is a type of brain tumor. Most commonly found in the temporal lobe, DNTs ... Dysembryoplastic neuroepithelial tumours are often described as a low grade tumour because about 1.2% people under the age of ... Dysembryoplastic neuroepithelial tumours are classified as a benign tumour, Grade I of the World Health Organization (WHO) ...
There are higher water influx and efflux but less sodium and potassium in their body. Their total body water is higher in ... The hair cells located in the neuroepithelial structures in the inner ear acts as receptors. They convert mechanical energy by ... Ctenophorus caudicinctus body temperature in shade is 34.2 7 °C. They start their day on the ground and move higher throughout ... Their body temperatures are mostly kept cool because of higher atmospheres and less absorbance of the sun. If the weather isn't ...
This usually occurs as direct tumor spread from a vertebral body (85%) or by invasion of paravertebral masses through a ... neuroforamin (10-15%). Seizures are common in patients with low-grade tumors such as dysembryoblastic neuroepithelial tumors, ...
These structures include the type I cells of the carotid body, the neuroepithelial bodies of the lungs as well as some central ... "Hypoxia-induced secretion of serotonin from intact pulmonary neuroepithelial bodies in neonatal rabbit". J Physiol. 539 (Pt 2 ... In fish, the neuroepithelial cells (NEC) have been implicated as the major oxygen sensing cells. NEC have been found in all ... Since neuroepithelial cells are distributed throughout the gills, they are often ideally situated to detect both arterial as ...
The body of the lateral ventricle, or central part is the part of the ventricle between the anterior horn and the trigone. Its ... Ependyma, which are neuroepithelial cells, line the ventricular system including the lateral ventricles. Between the inferior ... The trigone of the lateral ventricle is the area where the part of the body forms a junction with the inferior horn and the ... As a continuation of the interior side of the ventricular curve, the floor of the body of the ventricle becomes the roof of the ...
IAA resulted in apoptosis of neuroepithelial cell and significantly decreased brain sizes relative to body weight in embryonic ... IAA treatment of pregnant rats, at a dose of 1 gram per kg of body weight per day, decreased the locomotor activities of rat ...
... must be differentiated from other kinds of possible "bodies" in the eye. After the body has been established as an ... The origin of primary cysts is neuroepithelial. Primary cysts are rarely causing any problems, fluid-filled and have smooth ... It can also be used to identify midzonal cysts behind the iris and to determine whether there is ciliary body involvement. The ... Primary cysts origin is neuroepithelial, and rarely causes any issue. Primary cysts can be subcategorized based on their ...
... neuroepithelial bodies MeSH A11.443.240.330 - erythrocytes, abnormal MeSH A11.443.240.330.100 - acanthocytes MeSH A11.443. ... heinz bodies MeSH A11.284.420.390 - inclusion bodies, viral MeSH A11.284.420.400 - intranuclear inclusion bodies MeSH A11.284. ... nissl bodies MeSH A11.284.430.214.190.500.950 - weibel-palade bodies MeSH A11.284.430.214.190.750 - cytoskeleton MeSH A11.284. ... 420.460 - lewy bodies MeSH A11.284.430.106 - cell nucleus MeSH A11.284.430.106.279 - cell nucleus structures MeSH A11.284. ...
facial cartilage aorticopulmonary septum of the developing heart and lungs ciliary body of the eye adrenal medulla Neural tube ... spinal cord and motor neurons retina posterior pituitary Neural plate Neuroectodermal neoplasm Neuroepithelial cell Larsen's ...
Epithelial tissues line the outer surfaces of organs and blood vessels throughout the body, as well as the inner surfaces of ... mesenchymal transition Epithelial polarity Glycocalyx Inner and Outer enamel epithelium Iris pigment epithelium Neuroepithelial ... It is therefore found where body linings have to withstand mechanical or chemical insult such that layers can be abraded and ... Epithelium lines both the outside (skin) and the inside cavities and lumina of bodies. The outermost layer of human skin is ...
... are specialized airway epithelial cells that occur as solitary cells or as clusters called neuroepithelial bodies (NEBs) in the ... The major center of neuroendocrine integration in the body is found in the hypothalamus and the pituitary gland. Here ... This area controls most anterior pituitary cells and thereby regulates functions in the entire body, like responses to stress, ...
... neuroepithelial cells MeSH A08.800.550.700.120.530.550 - neuroepithelial bodies MeSH A08.800.550.700.120.540 - olfactory ... neuroepithelial cells MeSH A08.800.550.700.500.600.350 - hair cells MeSH A08.800.550.700.500.600.350.350 - hair cells, inner ... carotid body MeSH A08.800.550.700.120.600.350 - glomus jugulare MeSH A08.800.550.700.120.600.360 - glomus tympanicum MeSH ... geniculate bodies MeSH A08.186.211.730.385.826.701.460 - intralaminar thalamic nuclei MeSH A08.186.211.730.385.826.701.485 - ...
Satellite glial cell: Line the surface of neuron cell bodies in ganglia (groups of nerve body cells bundled or connected ... Dysembryoplastic neuroepithelial tumour, Oligodendroglioma, Medulloblastoma, Primitive neuroectodermal tumor ... Axons are long projections that carry the action potential away from the cell body toward the next neuron. The bulb-like end of ... In the PNS, the ganglion tissue, containing the cell bodies and dendrites, contain relay points for nerve tissue impulses. The ...
The spaces ultimately drain fluid from neuronal cell bodies to the cervical lymph nodes. In particular, the "tide hypothesis" ... leukomalacia cryptococcosis multiple sclerosis mucopolysaccharidoses neurocysticercosis arachnoid cysts neuroepithelial cysts ...
... such as rounded cell bodies and processes. NTERA-2 cells can also produce a small number of oligodendrocyte-type cells, but ... which are found in neuroepithelial precursor cells, as well as microtubule-associated proteins expressed in human ...
Senescence is when cells stop dividing but don't die, but these cells can build up and cause problems in the body. These cells ... Next, the closed neural tube contains neuroepithelial cells that immediately divide after closure and a second type of cell ... The process of an organism's body undergoing structural and physical changes after birth or hatching to become suitable for its ... In more advanced organisms like amphibians, birds and mammals; the spinal ganglions consists of a cluster of nerve bodies ...
It is the cell bodies of the follower neurons that follow the axons of the pioneer neurons, instead of what it was thought ... Although the role of Cdh2 in controlling adhesion of neuroepithelial cells possibly contributes to the FBMN migration defects ... In zebrafish, the ablation of either the cell body or the axon of the pioneer FBMN (facial brachiomotor neuron), blocks the ... dependent on the relative position of the cell body in its ganglion, while pioneers connect with posterior neuromasts, ...
Neoplasm Neuroepithelial cell Astrocytes Glial cells Brain cancer Unal, Ekrem, and Yavuz Koksal. "Astroblastoma in a Child." ... Lumbar pain and lower body weakness is also a rarity in astroblastoma patients, even though it is entirely possible for lesions ... Since the motor system can be impaired with severe cases, the malignant spread of astroblastoma throughout the body may press ... Pleomorphic xanthoastrocytoma, dysembryoplastic neuroepithelial tumors, juvenile pilocytic astrocytoma, and hemangioblastoma ...
... , or ciliary body medulloepithelioma, or teratoneuroma, is a rare tumor arising from primitive medullary epithelium in ... Neuroepithelial Lesions of the Ocular Globe and Optic Nerve". RadioGraphics. 27 (4): 1159-1186. doi:10.1148/rg.274075014. PMID ... Almost all diktyomas arise in the ciliary body, although, rarely, they may arise from the optic nerve head or retina. The name ... On CT, dityomas typically appear as dense, irregular masses in the ciliary body, which enhances with administration of ...
Therefore, many tracers that may reach tumors in other areas of the body easily would be unable to reach brain tumors until ... Dysembryoplastic neuroepithelial tumour, Ependymal tumor, Fibrillary astrocytoma, Giant-cell glioblastoma, Glioblastoma ... This means that a cancerous neoplasm has developed in another organ elsewhere in the body and that cancer cells have leaked ... Brain tumors, when compared to tumors in other areas of the body, pose a challenge for diagnosis. Commonly, radioactive tracers ...
These cells are involved in various reflexive responses of the brain and body to the presence of (day)light, such as the ... A photoreceptor cell is a specialized type of neuroepithelial cell found in the retina that is capable of visual ... Farther back is the cell body, which contains the cell's organelles. Farther back still is the inner segment, a specialized ...
Neural induction is often studied in xenopus embryos since they have a simple body pattern and there are good markers to ... The wall of the neural tube consists of neuroepithelial cells, which differentiate into neuroblasts, forming the mantle layer ( ... Many neurons migrating along the anterior-posterior axis of the body use existing axon tracts to migrate along in a process ...
... carotid body tumor MeSH C04.557.465.625.650.700.705.340 - glomus jugulare tumor MeSH C04.557.465.625.650.700.705.360 - glomus ... neuroepithelial MeSH C04.557.465.625.600.355 - ganglioneuroma MeSH C04.557.465.625.600.380 - glioma MeSH C04.557.465.625. ... carotid body tumor MeSH C04.557.580.625.650.700.705.340 - glomus jugulare tumor MeSH C04.557.580.625.650.700.705.360 - glomus ... neuroepithelial MeSH C04.557.470.670.355 - ganglioneuroma MeSH C04.557.470.670.380 - glioma MeSH C04.557.470.670.380.080 - ...
Their cell bodies (somata) reside in the embryonic ventricular zone, which lies next to the developing ventricular system. ... Radial glial cells originate from the transformation of neuroepithelial cells that form the neural plate during neurogenesis in ... List of distinct cell types in the adult human body Kirsch F, Krüger C, Schneider A (March 2008). "The receptor for granulocyte ... radial glia retain many of the original characteristics of neuroepithelial cells including: their apical-basal polarity, their ...
Tumours originating in the ciliary body of the eye are referred to as embryonal medulloepitheliomas, or diktyomas. A highly ... Congenital cerebellar neuroepithelial tumor with multiple divergent differentiation. Acta Neuropathol 1980;50:143-6. ... Medulloepithelioma of the ciliary body. Indian J Ophthalmol. 2002 Jun;50(2):138-40. Vajaranant, TS, Mafee, MF, Kapur, R, et al ... Medulloepithelioma of the ciliary body and optic nerve: clinicopathologic, CT, and MR imaging features. Neuroimaging Clin N Am ...
The same is true for other developmental boundaries in the brain and throughout the body: shifts in boundaries responsible for ... or neuroepithelial tissue (see figure). Interactions between these tissues may be responsible for the recession of expression ... cell lineage restriction boundaries and signaling centers are formed in order to ensure proper differentiation of the body. ... the embryo is completely undifferentiated and requires many different cues to initiate proper differentiation of the body. The ...
The bodies of these neurons remain stationary while the axons follow a path defined by netrins, eventually connecting to ... Netrin-1 is found in the floor plate and neuroepithelial cells of the ventral region of the spinal cord, as well as other ... Netrin 1 has been found to inhibit leukocyte migration to inflamed areas in the body. This provides evidence that the up ... recent research has attempted to identify netrin-1 as a biomarker for the onset of cancer in the human body. It was found that ...
... ... Neuroepithelial Body Microenvironment Is a Niche for a Distinct Subset of Clara-Like Precursors in the Developing Airways. ... Furthermore, we identified a subpopulation of secretory precursors juxtaposed to presumptive neuroepithelial bodies (NEBs), ...
Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of Prolyl Hydroxylase −1(PHD-1) Deficient Mice Share Share Share ... Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of Prolyl Hydroxylase −1(PHD-1) Deficient Mice ...
Lauweryns JM, Cokelaere J, Theunynck P (April 1973). "Serotonin producing neuroepithelial bodies in rabbit respiratory mucosa ... I. Studies of isolated neuroepithelial bodies". Experimental Lung Research. 3 (3-4): 349-377. doi:10.3109/01902148209069663. ... contains specialized epithelial cells that occur as solitary cells or as clusters called neuroepithelial bodies or bronchial ... "Morphological and cytochemical characterization of neuroepithelial bodies in fetal rabbit lung. ...
Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice ... Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice ...
... pulmonary arterioles and neuroepithelial bodies), while their absence may explain the lack of response to hypoxia elsewhere and ... in neuroepithelial bodies of the lung and in PASMCs [25, 50-54]. ... Message Body (Your Name) thought you would like to see the ... et al. Heteromeric TASK-1/TASK-3 is the major oxygen-sensitive background K+ channel in rat carotid body glomus cells. J ... The respiratory stimulants, doxapram, PKTHPP and A1899, inhibit TASK-1/TASK-3 channels and may act in the carotid body [40, 83 ...
Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways ... Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration ... Neuroepithelial bodies as mechanotransducers in the intrapulmonary airway epithelium: involvement of TRPC5 ... Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining ...
The pulmonary neuroepithelial bodies (NEBs) constitute polymodal airway chemosensors for monitoring. immune Actin CDC25A, PAC-1 ... The pulmonary neuroepithelial bodies (NEBs) constitute polymodal airway chemosensors for monitoring and signaling ambient gas ... Body 1 Recruitment of PR-Set7 to DSBs is essential for NHEJ-directed fix While these outcomes demonstrate that PR-Set7 is ... Body S1A and S1B). Short-term PR-Set7 depletion led to the speedy and significant drop of practical U2Operating-system cells ...
keywords = "PULMONARY NEUROENDOCRINE CELLS, NEURAL STEM-CELLS, NEUROEPITHELIAL BODIES, GENE-EXPRESSION, EPIDEMIOLOGIC EVIDENCE ...
... the expression of hASH1 and the neural marker synaptophysin was highly concordant in neuroepithelial bodies and solitary NE ...
ventricular zone - Neuroepithelial cell layer of neural tube closest to lumen. Neuroepithelial cells generate neurons, glia and ... grey matter - neural regions containing cell bodies (somas) of neurons. In the brain it is the outer layer, in the spinal cord ... 2015). Cellular basis of neuroepithelial bending during mouse spinal neural tube closure. Dev. Biol. , 404, 113-24. PMID: ... rhombic lip - metencephalon posterior part extending from the roof of the fourth ventricle to dorsal neuroepithelial cells that ...
Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors. The American journal of pathology ... Collectively, our findings expose a select vulnerability of the neuroepithelial lineage to postnatal tumorigenesis and provide ... Function of the mature central nervous system (CNS) requires a substantial proportion of the bodys energy consumption. During ... Parallel MYC expression in the ciliary body leads also to up-regulation of protein biosynthetic machinery. Additionally, Myc ...
Embryoid bodies were fed every 48h. At day 6 the embryoid bodies were transferred to low attachment 24 well plates (Corning, # ... At day 7 the neuroepithelial tissues were embedded in 20-30µL of Matrigel and embedded organoids were then placed in a 5cm ... Embryoid bodies were fed every 48h and were not transferred to 24-well plates remaining in the 96-well plates. On day 6 dual ... Embryoid bodies were maintained as described above, embedded in Matrigel at day 11-12 but kept in induction media from days 5/6 ...
The organoid showed neuroepithelial bud expansion as day 14; then, it was transferred to the orbital shaker for further ... Human iPSCs form embryo bodies, developed into neuroectoderm and finally differentiated into neural epithelium and cerebral ... made embryoid bodies (EBs) from iPSCs colonies in a six-well plate coated with irradiated MEFs. After 7 days, EBs were then ...
neuroepithelial neoplasm DOID:3094 * malignant ciliary body melanoma DOID:6524 * juvenile pilocytic astrocytoma ...
Proost, I., Robertson, H., Stanton, P. K., & Wu, J. (2008). Functional live cell imaging of the pulmonary neuroepithelial body ... It plays a significant role in eliminating unhealthy or exhausted cells from the body and its involvement in many biological ...
Functional morphology of pulmonary neuroepithelial bodies: extremely complex airway receptors. Anat Rec A Discov Mol Cell Evol ... During initial clinical examinations, patient demographics were recorded for each patient,, including age, gender Body Mass ...
O Abnormality of body height,O Abnormality of body mass index,O Abnormality of body weight,O Abnormality of bone marrow cell ... O Neuroepithelial neoplasm,O Neurofibrillary tangles,O Neurofibromas,O Neurofibrosarcoma,O Neurogenic bladder,O Neurogenic ... O Increased body fat percentage,O Increased body mass index,O Increased body weight,O Increased bone density with cystic ... O Decreased body mass index,O Decreased body weight,O Decreased calvarial ossification,O Decreased carnitine level in liver,O ...
... indicated that intrapulmonary conducting airways contain rare populations of stem cells that localized to neuroepithelial body ...
The effects of the auditory brainstem response before and after fluoro-gold injection in medial geniculate body.. Zhu M, He G, ... Yang C, Li X, Liu Y, Li H, Guo Z, Lin J. Sonic hedgehog overexpression regulates the neuroepithelial cells proliferation in the ... Sonic hedgehog overexpression regulates the neuroepithelial cells proliferation in the spinal cord of dorsal regions during ... Geniculate Bodies, Inferior Colliculi, Injections, Male, Neurons, Stilbamidines:pharmacology, Superior Olivary Compl. Citation ...
For example, all retinal ganglion cells (RGCs) send out their axons from the basal part of the cell body (Hinds and Hinds, 1974 ... What orients axon emergence in vivo? Neurons in the brain derive from highly polarized neuroepithelial cells, with distinct ...
Neuroepithelial body micro- environment is a niche for a distinct subset of Clara-like precursors in the developing airways. ...
Glycogen storage disease type 0 (also known as GSD 0) is a condition caused by the bodys inability to form a complex sugar ... A highly malignant undifferentiated primitive neuroepithelial tumour of children, medulloepithelioma may contain bone , ... The lesions typically begin in the face and rapidly expand to other parts of the body. The disease may be complicated by ... Even though Axenfeld-Rieger syndrome is primarily an eye disorder, this syndrome can affect other parts of the body. Most ...
... entire intrapulmonary airway tree of the adult rat and the anatomical relationship between nerves and neuroepithelial bodies. ...
Neuroepithelial cell competition triggers loss of cellular juvenescence. Jam, Faidruz Azura; Morimune, Takao; Tsukamura, ... The cell bodies of eliminated cells were engulfed by the surrounding cells through phagocytosis. Our data indicates that ... Here we aimed to identify a role for cell competition in the elimination of suboptimal cells using an in vitro neuroepithelial ... The apical Bex1 localizes to the basal body. Bex1 knockout mice present ciliopathy phenotypes and exhibit ciliary defects in ...
Schinzel-Giedion syndrome is a severe condition that is apparent at birth and affects many body systems. Explore symptoms, ... Schinzel-Giedion syndrome is a severe condition that is apparent at birth and affects many body systems. Signs and symptoms of ... who survive past infancy have a higher than normal risk of developing certain types of brain tumors called neuroepithelial ... the chambers of the heart that pump blood to the body (ventricles); or the dividing wall between the sides of the heart (the ...
These lytic bone lesions are usually limited to the vertebral bodies, but they can cross the joint spaces. Patients can develop ... Neuroepithelial cells in tuberous sclerosis * Hamartomas of the hypothalamus and tuber cinereum ... Uncomplicated hamartomas have no tendency to grow, except as determined by the normal growth controls of the body. However, ... Although hemangiomas of bone are the most frequently occurring tumors in the vertebral body, they are usually incidental ...
E4.502.250.700 Neuroepithelial Bodies A8.663.650.915.500.530.550 A8.675.650.915.500.530.550 Neuroepithelial Cells A8.663. ... E4.800.515 Mamillary Bodies A8.186.211.464.497.362.500 (Replaced for 2014 by Mammillary Bodies) Marijuana Smoking F1.145. ... D4.711.511 Lewy Bodies A8.663.460 A8.675.460 Liniments D27.720.280.480 Liposomes D27.720.280.260.517 Lissencephaly C10.500. ... A8.186.211.464.497.342.63 Aortic Bodies A8.663.650.915.500.600.50 A8.675.650.915.500.600.50 Arcuate Nucleus A8.186.211.464. ...
E4.502.250.700 Neuroepithelial Bodies A8.663.650.915.500.530.550 A8.675.650.915.500.530.550 Neuroepithelial Cells A8.663. ... E4.800.515 Mamillary Bodies A8.186.211.464.497.362.500 (Replaced for 2014 by Mammillary Bodies) Marijuana Smoking F1.145. ... D4.711.511 Lewy Bodies A8.663.460 A8.675.460 Liniments D27.720.280.480 Liposomes D27.720.280.260.517 Lissencephaly C10.500. ... A8.186.211.464.497.342.63 Aortic Bodies A8.663.650.915.500.600.50 A8.675.650.915.500.600.50 Arcuate Nucleus A8.186.211.464. ...
  • Children with Schinzel-Giedion syndrome who survive past infancy have a higher than normal risk of developing certain types of brain tumors called neuroepithelial tumors. (medlineplus.gov)
  • Primary neuroendocrine tumors of the lung NTLs originate either from Kulchitzky cells, neuroepithelial bodies or from pluripotent stem cells which are present in the bronchial mucosa, with similar pathological features, and being capable of producing and secreting peptide hormones and neuroamines 2. (adventube.ro)
  • Gliomas, tumors derived from neuroepithelial cells (astrocytes, oligodendrocytes, and ependymal cells), account for the majority of these primary CNS tumors. (cdc.gov)
  • Furthermore, we identified a subpopulation of secretory precursors juxtaposed to presumptive neuroepithelial bodies (NEBs), distinguished by their strong Scgb3a2 and uroplakin 3a (Upk3a) signals and reduced Ccsp (Scgb1a1) expression. (harvard.edu)
  • Approximately 90% of the serotonin the human body produces is in the gastrointestinal tract's enterochromaffin cells, where it regulates intestinal movements. (wikipedia.org)
  • It plays a significant role in eliminating unhealthy or exhausted cells from the body and its involvement in many biological processes has been well characterized. (utoronto.ca)
  • Previous results indicated that intrapulmonary conducting airways contain rare populations of stem cells that localized to neuroepithelial body (NEB) microenvironments, and that these cells are activated following injury involving depletion of airway Clara cells. (pitt.edu)
  • Sonic hedgehog overexpression regulates the neuroepithelial cells proliferation in the spinal cord of dorsal regions during chicken embryo development. (nel.edu)
  • Yang C, Li X, Liu Y, Li H, Guo Z, Lin J. Sonic hedgehog overexpression regulates the neuroepithelial cells proliferation in the spinal cord of dorsal regions during chicken embryo development. (nel.edu)
  • The simultaneous presence of neuroepithelial cells and neuroepithelial bodies in the respiratory gas bladder of the longnose gar, Lepisosteus osseus , and the spotted gar, L. oculatus . (krakow.pl)
  • A hamartoma (from Greek hamartia, meaning "fault, defect," and -oma, denoting a tumor or neoplasm) is a benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues found in areas of the body where growth occurs. (medscape.com)
  • Though there offers been progress in understanding the function of NE cells, the physiological part of NE cells in most additional body organs is definitely not well recognized. (brain-tumor-cancer-information.com)
  • We investigated whether this sensitivity is maintained in trout chronically exposed (1+ months) to high environmental ammonia [HEA, 250 μmol l -1 (NH 4 ) 2 SO 4 ] in the water, and whether gill neuroepithelial cells (NECs) are involved in ammonia sensing. (silverchair.com)
  • As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
  • In the ventricular and subventricular regions of trout telencephalon, CBS+ cells, as well as neuroepithelial and glial types, were detected. (intechopen.com)
  • As a result of injury, the number of CBS+ neuroepithelial cells in the pallial and subpallial periventricular regions of the telencephalon increases. (intechopen.com)
  • In the tectum, a traumatic damage leads to an increase in the CBS expression in radial glia with a simultaneous decrease in the number of CBS immunopositive neuroepithelial cells detected in intact animals. (intechopen.com)
  • These markers of senescence specifically appeared in exposed neuroepithelial cells, a type of stem cell that later produces brain cells. (livescience.com)
  • The researchers exposed the organoids to valproic acid and found that the drug pushed the organoids' neuroepithelial cells into senescence, just as it had in the mouse embryos. (livescience.com)
  • Altered G Protein Coupling in Olfactory Neuroepithelial Cells From Patients With Schizophrenia. (jefferson.edu)
  • The lens is suspended by ligaments (called zonule fibers) attached to the anterior portion of the ciliary body. (utah.edu)
  • The nose and the oral cavities are the main sites for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into the body. (wjgnet.com)
  • When your body releases too much histamine or is unable to break it down, it can cause symptoms that we typically associate with allergic reactions, such as: nasal congestion hives headaches itchy skin rapid heartbeat flushing difficulty breathing. (tinkerstorm.de)
  • In this review, we summarize recent studies that have explored the relationship between the Hippo signaling pathway and growth of optic neuroepithelial compartments. (molcells.org)
  • Jun 10, 2022 · How do high levels of histamine affect the body? (tinkerstorm.de)
  • Overall it is clear that there is an interconnection in the body between histamine , oestrogen, progesterone and cortisol in regards to systemic functionality. (tinkerstorm.de)
  • Histamine is a biogenic amine, widely distributed in the body. (geneceutica.ro)
  • The sagittal section of the eye also reveals the lens which is a transparent body located behind the iris. (utah.edu)
  • Schinzel-Giedion syndrome is a severe condition that is apparent at birth and affects many body systems. (medlineplus.gov)
  • When taken as a treatment for epilepsy or bipolar disorder, valproic acid affects the body in several ways, according to the online medical database StatPearls . (livescience.com)
  • Uncomplicated hamartomas have no tendency to grow, except as determined by the normal growth controls of the body. (medscape.com)
  • The fish brain has a unique feature of vertebrates-it grows with the growth of body over a lifetime. (intechopen.com)
  • It is involved in various processes of the body, including digestive processes, vascular regulation, allergic reactions and inflammatory processes. (geneceutica.ro)
  • The SETBP1 protein is found throughout the body, but protein levels are highest during brain development before birth. (medlineplus.gov)
  • But it's also involved in digestion, and boosting exercise performance, and increasing attention, as well as getting nutrients and oxygen delivered to different parts of the body. (tinkerstorm.de)
  • So you can always keep the source of the EMF far enough away from you to minimize the impact to your beautiful body. (techwellness.com)
  • If cortisol levels in the body are low, inflammation goes unchecked. (tinkerstorm.de)
  • Optogenetic manipulation of apical constriction caused multiple types of tissue deformation, including neuroepithelial thickening and apical lumen shrinkage of neural organoids (Figure 4). (embl.org)
  • Pulmonary neuroepithelial bodies (NEB) are presumed airway chemoreceptors involved in respiratory control, especially in the neonate. (mcmaster.ca)
  • During cortical development, RGs are present in different strategic positions: apical RGs (aRGs) have their cell bodies located in the ventricular zone with an apical process contacting the ventricle, while they also have a basal process extending radially to reach the pial surface of the cortex. (frontiersin.org)
  • In the adult ciliary body, VEGF-A was expressed by the pigmented epithelium, whereas VEGFR2 was localized primarily to the capillary endothelium and nonpigmented epithelium. (arvojournals.org)
  • It is rare for medulloblastomas to spread to the bone, bone marrow , lung , or other parts of the body. (oncolink.org)
  • The part of the nasal mucosa composed of neuroepithelial tissue and mucus-producing Bowman's glands. (medindex.am)
  • Banaceur S, Banasr S, Sakly M et al (2013) Whole body exposure to 2.4 GHz WIFI signals: effects on cognitive impairment in adult triple transgenic mouse models of Alzheimer's disease (3xTg-AD). (springer.com)
  • In normal control adult mouse eyes, ETS-1 was mostly present in the nuclei of all neuroretinal layers whereas ETS-2 was mostly localized in the cytosol of the cell bodies of these layers with a smaller amount present in the nuclei. (molvis.org)
  • These data suggest that kidney ACE activity decrease are due to renal damage and an universal signal increases the ACE contents in the body probably to increase systemic blood pressure and subsequently increase glomerular filtration rate (GFR). (ac.ir)
  • 2. Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumor s. (nih.gov)
  • This makes it ideal for localising not only degenerating nerve cell bodies but also distal dendrites, axons and terminals. (newmarketscientific.com)
  • In line with this, Hinds and Hinds [ 14 ], in their serial electron microscopic studies of the developing mouse retina, suggested that the axons of RGCs arise from the basal process of neuroepithelial-like precursors. (biomedcentral.com)
  • The significance of this is that fat and ketone bodies as a source of energy require oxygen while glucose doesn't. (second-opinions.co.uk)
  • Castaño-Vinyals G, Sadetzki S, Vermeulen R et al (2022) Wireless phone use in childhood and adolescence and neuroepithelial brain tumours: results from the international MOBI-Kids study. (springer.com)
  • A brain tumor that starts in another part of the body and spreads to the brain is called a metastatic tumor. (shyamhemoncclinic.com)
  • The brain controls many important body functions. (shyamhemoncclinic.com)
  • The spinal cord connects the brain to nerves in most parts of the body. (shyamhemoncclinic.com)
  • Spinal cord nerves carry messages between the brain and the rest of the body, such as a signal from the brain to cause muscles to move or from the skin to the brain about the sense of touch. (shyamhemoncclinic.com)
  • Nevertheless, soluble elements or cytokines that control the locks cell differentiation in the body organ of Corti stay to become elucidated. (immune-source.com)
  • a protein which aids the formation Lewy bodies that develop inside nerves. (lagas.org)
  • Due to these pathophysiologicalcharacteristics, PD clinical motor symptoms range from muscular rigidity to akinesia,resting tremor, postural instability and lately, in several nonmotor symptoms.Intracellular inclusions of aggregated α-synuclein (α-Syn) in the form of Lewy Bodies(LBs) are the main hallmark of this disease. (uc.pt)
  • As part of his studies on Cell biology, Kenneth H. Pollock often connects relevant areas like Neuroepithelial cell. (research.com)
  • His work on Neuroepithelial cell is being expanded to include thematically relevant topics such as Cell biology. (research.com)
  • All of the process let cell to controlled internal space also body fluids. (geneandcells.com)
  • This vicious cycle increases body wasting,[3] which is one reason some 40% of patients die from malnutrition (cachexia). (second-opinions.co.uk)
  • Prenatal WiFi exposure increased the body weight, improved the spatial memory and learning function, and induced behavioral hyperactivity of male rats. (springer.com)
  • Ethylene thiourea is teratogenic to rats and the overall NOAEL for the teratogenic effect on this species is estimated to be 5 mg per kilogram body weight per day. (europa.eu)
  • On PND7-42, we evaluated the development and behavior of the offspring, including body weight, pain threshold, and swimming ability, spatial learning, and memory among others. (springer.com)
  • They may also spread to other parts of the body, but this is rare. (oncolink.org)
  • Mosaic analysis in four dimensions, using mutants in which neuroepithelial polarity is disrupted, indicates that extrinsic factors such as access to the basal lamina are critical for normal axon emergence from RGCs in vivo . (biomedcentral.com)
  • Uncomplicated hamartomas have no tendency to grow, except as determined by the normal growth controls of the body. (medscape.com)
  • The techniques that follow to attain the motility routine consist of formation of adhesion buildings that stabilize the protrusion [7] advancement of contractile drive that translocates the cell body forwards discharge of adhesion buildings on the cell back and lastly retraction from the cell to the path of motility [8]. (biodiversityhotspot.org)
  • Hereby we would like to present a case report of a 27-year-old male patient with drug- -resistant structural epilepsy based on the diagnosis of the polymorphous low-grade neuroepithelial tumor of the young (PLNTY), first reported by Huse et al in 2017 [1]. (muni.cz)
  • So that day after day, week after week, year after year, your body is being exposed to radiation that has been proven to have biological effects. (techwellness.com)