Neuraminidase. Medical search

An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)

A guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.

A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.

An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.

The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.

A family of RNA viruses causing INFLUENZA and other diseases. There are five recognized genera: INFLUENZAVIRUS A; INFLUENZAVIRUS B; INFLUENZAVIRUS C; ISAVIRUS; and THOGOTOVIRUS.

An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)

Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.

An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.

Agglutination of ERYTHROCYTES by a virus.

A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.

Specific hemagglutinin subtypes encoded by VIRUSES.

Virus diseases caused by the ORTHOMYXOVIRIDAE.

Species of the genus INFLUENZAVIRUS B that cause HUMAN INFLUENZA and other diseases primarily in humans. Antigenic variation is less extensive than in type A viruses (INFLUENZA A VIRUS) and consequently there is no basis for distinct subtypes or variants. Epidemics are less likely than with INFLUENZA A VIRUS and there have been no pandemics. Previously only found in humans, Influenza B virus has been isolated from seals which may constitute the animal reservoir from which humans are exposed.

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 3 and neuraminidase 2. The H3N2 subtype was responsible for the Hong Kong flu pandemic of 1968.

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 1. The H5N1 subtype, frequently referred to as the bird flu virus, is endemic in wild birds and very contagious among both domestic (POULTRY) and wild birds. It does not usually infect humans, but some cases have been reported.

Infection of domestic and wild fowl and other BIRDS with INFLUENZA A VIRUS. Avian influenza usually does not sicken birds, but can be highly pathogenic and fatal in domestic POULTRY.

The ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. This resistance is acquired through gene mutation.

An enzyme that oxidizes galactose in the presence of molecular oxygen to D-galacto-hexodialdose. It is a copper protein. EC 1.1.3.9.

Semidomesticated variety of European polecat much used for hunting RODENTS and/or RABBITS and as a laboratory animal. It is in the subfamily Mustelinae, family MUSTELIDAE.

Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.

Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.

Glycoprotein from Sendai, para-influenza, Newcastle Disease, and other viruses that participates in binding the virus to cell-surface receptors. The HN protein possesses both hemagglutinin and neuraminidase activity.

Viruses containing two or more pieces of nucleic acid (segmented genome) from different parents. Such viruses are produced in cells coinfected with different strains of a given virus.

Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.

Derivatives of acetamide that are used as solvents, as mild irritants, and in organic synthesis.

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 2 and neuraminidase 2. The H2N2 subtype was responsible for the Asian flu pandemic of 1957.

A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 7 and neuraminidase 9. This avian origin virus was first identified in humans in 2013.

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 9 and neuraminidase 2. The H9N2 subtype usually infects domestic birds (POULTRY) but there have been some human infections reported.

The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

The most well known avian paramyxovirus in the genus AVULAVIRUS and the cause of a highly infectious pneumoencephalitis in fowl. It is also reported to cause CONJUNCTIVITIS in humans. Transmission is by droplet inhalation or ingestion of contaminated water or food.

Vaccines used to prevent infection by viruses in the family ORTHOMYXOVIRIDAE. It includes both killed and attenuated vaccines. The composition of the vaccines is changed each year in response to antigenic shifts and changes in prevalence of influenza virus strains. The vaccine is usually bivalent or trivalent, containing one or two INFLUENZAVIRUS A strains and one INFLUENZAVIRUS B strain.

The most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins.

Proteins found in any species of virus.

Established cell cultures that have the potential to propagate indefinitely.

Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.

Lectins purified from the germinating seeds of common wheat (Triticum vulgare); these bind to certain carbohydrate moieties on cell surface glycoproteins and are used to identify certain cell populations and inhibit or promote some immunological or physiological activities. There are at least two isoforms of this lectin.

A species of RESPIROVIRUS frequently isolated from small children with pharyngitis, bronchitis, and pneumonia.

An epithelial cell line derived from a kidney of a normal adult female dog.

The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.

A phenomenon manifested by an agent or substance adhering to or being adsorbed on the surface of a red blood cell, as tuberculin can be adsorbed on red blood cells under certain conditions. (Stedman, 25th ed)

Lectin purified from peanuts (ARACHIS HYPOGAEA). It binds to poorly differentiated cells and terminally differentiated cells and is used in cell separation techniques.

Warm-blooded VERTEBRATES possessing FEATHERS and belonging to the class Aves.

A carboxypeptidase that catalyzes the release of a C-terminal amino acid with a broad specificity. It also plays a role in the LYSOSOMES by protecting BETA-GALACTOSIDASE and NEURAMINIDASE from degradation. It was formerly classified as EC 3.4.12.1 and EC 3.4.21.13.

Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.

A subclass of ACIDIC GLYCOSPHINGOLIPIDS. They contain one or more sialic acid (N-ACETYLNEURAMINIC ACID) residues. Using the Svennerholm system of abbrevations, gangliosides are designated G for ganglioside, plus subscript M, D, or T for mono-, di-, or trisialo, respectively, the subscript letter being followed by a subscript arabic numeral to indicated sequence of migration in thin-layer chromatograms. (From Oxford Dictionary of Biochemistry and Molecular Biology, 1997)

Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.

A group of alicyclic hydrocarbons with the general formula R-C5H9.

The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.

Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)

A family of spherical viruses, of the order MONONEGAVIRALES, somewhat larger than the orthomyxoviruses, and containing single-stranded RNA. Subfamilies include PARAMYXOVIRINAE and PNEUMOVIRINAE.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.

Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.

A strong oxidizing agent.

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

A group of inherited metabolic diseases characterized by the accumulation of excessive amounts of acid mucopolysaccharides, sphingolipids, and/or glycolipids in visceral and mesenchymal cells. Abnormal amounts of sphingolipids or glycolipids are present in neural tissue. INTELLECTUAL DISABILITY and skeletal changes, most notably dysostosis multiplex, occur frequently. (From Joynt, Clinical Neurology, 1992, Ch56, pp36-7)

The sum of the weight of all the atoms in a molecule.

The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).

Immunoglobulins produced in response to VIRAL ANTIGENS.

A genus of asporogenous bacteria isolated from soil that displays a distinctive rod-coccus growth cycle.

Epidemics of infectious disease that have spread to many countries, often more than one continent, and usually affecting a large number of people.

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.

The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.

Glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.

A proteolytic enzyme obtained from Streptomyces griseus.

Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.

A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.

An amidohydrolase that removes intact asparagine-linked oligosaccharide chains from glycoproteins. It requires the presence of more than two amino-acid residues in the substrate for activity. This enzyme was previously listed as EC 3.2.2.18.

A family of bacteria including numerous parasitic and pathogenic forms.

The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.

A species of RESPIROVIRUS also called hemadsorption virus 2 (HA2), which causes laryngotracheitis in humans, especially children.

Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.

A genus of the family PARAMYXOVIRIDAE (subfamily PARAMYXOVIRINAE) where all the virions have both HEMAGGLUTININ and NEURAMINIDASE activities and encode a non-structural C protein. SENDAI VIRUS is the type species.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Sites on an antigen that interact with specific antibodies.

A group of related enzymes responsible for the endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose-content glycopeptides and GLYCOPROTEINS.

Enzymes that catalyze the cleavage of a carbon-carbon bond of a 3-hydroxy acid. (Dorland, 28th ed) EC 4.1.3.

The effects of digestive enzymes on characteristics of placental insulin receptor. Comparison of particulate and soluble receptor preparations. (1/3160)

The role of the surrounding membrane structure on the binding characteristics of the insulin receptor was studied by using several digestive enzymes. The effects observed with particulate membrane preparations are compared with those from soluble receptor preparations. beta-Galactosidase and neuraminidase had no effect on insulin binding to either particulate or soluble receptors from human placentae. Exposure to 2 units of phospholipase C/ml increased insulin binding to particulate membranes, but was without effect on the soluble receptor preparation. The increase in binding to particulate membranes was shown to be due to an increase in apparent receptor number. After 5 min exposure to 500 microgram of trypsin/ml there was an increase in insulin binding to the particulate membrane fraction, owing to an increase in receptor affinity. After 15 min exposure to this amount of trypsin, binding decreased, owing to a progressive decrease in receptor availability. In contrast, this concentration of trypsin had no effect on the solubilized receptor preparation. Because of the differential effects of phospholipase C and trypsin on the particulate compared with the solubilized receptor preparations, it is concluded that the effects of these enzymes were due to an effect on the surrounding membrane structure. Changes in receptor configuration due to alterations within the adjoining membrane provide a potential mechanism for mediating short-term alterations in receptor function. (+info)

Cell surface sialic acid and the regulation of immune cell interactions: the neuraminidase effect reconsidered. (2/3160)

It has been known for over a decade that sialidase (neuraminidase) treatment could substantially enhance the capacity of resting B cells to stimulate the proliferation of allogeneic and antigen specific, syngeneic T cells. Thus, cell-surface sialic acid was implicated as a potential modulator of immune cell interaction. However, little progress has been made in either identifying explicit roles for sialic acid in this system or in hypothesizing mechanisms to explain the "neuraminidase effect." Here we show for the first time that cell surface sialic acid on medium incubated B cells blocks access to costimulatory molecules on the B cell surface, and that this is the most likely explanation for the neuraminidase effect. Further, we show that it is likely to be upregulation of ICAM-1 and its subsequent engagement of LFA-1 rather than loss of cell surface sialic acid that in part regulates access to CD86 and other costimulatory molecules. However, we cannot exclude a role for CD86-bound sialic acid on the B cell in modulating binding to T cell CD28. Because sialidase treatment of resting B cells but not resting T cells enables T cell activation, we suggest that sialidase treatment may still be an analogue for an authentic step in B cell activation, and show that for highly activated B cells (activated with polyclonal anti-IgM plus INF-gamma) there is specific loss 2, 6-linked sialic acid. Potential roles for sialic acid in modulating B cell/T cell collaboration are discussed. (+info)

N-Linked glycosylation and sialylation of the acid-labile subunit. Role in complex formation with insulin-like growth factor (IGF)-binding protein-3 and the IGFs. (3/3160)

Over 75% of the circulating insulin-like growth factors (IGF-I and -II) are bound in 140-kDa ternary complexes with IGF-binding protein-3 (IGFBP-3) and the 84-86-kDa acid-labile subunit (ALS), a glycoprotein containing 20 kDa of carbohydrate. The ternary complexes regulate IGF availability to the tissues. Since interactions of glycoproteins can be influenced by their glycan moieties, this study aimed to determine the role of ALS glycosylation in ternary complex formation. Complete deglycosylation abolished the ability of ALS to associate with IGFBP-3. To examine this further, seven recombinant ALS mutants each lacking one of the seven glycan attachment sites were expressed in CHO cells. All the mutants bound IGFBP-3, demonstrating that this interaction is not dependent on any single glycan chain. Enzymatic desialylation of ALS caused a shift in isoelectric point from 4.5 toward 7, demonstrating a substantial contribution of anionic charge by sialic acid. Ionic interactions are known to be involved in the association between ALS and IGFBP-3. Desialylation reduced the affinity of ALS for IGFBP-3. IGF complexes by 50-80%. Since serum protein glycosylation is often modified in disease states, the dependence of IGF ternary complex formation on the glycosylation state of ALS suggests a novel mechanism for regulation of IGF bioavailability. (+info)

Binding partners for the myelin-associated glycoprotein of N2A neuroblastoma cells. (4/3160)

The myelin-associated glycoprotein (MAG) has been proposed to be important for the integrity of myelinated axons. For a better understanding of the interactions involved in the binding of MAG to neuronal axons, we performed this study to identify the binding partners for MAG on neuronal cells. Experiments with glycosylation inhibitors revealed that sialylated N-glycans of glycoproteins represent the major binding sites for MAG on the neuroblastoma cell line N2A. From extracts of [3H]glucosamine-labelled N2A cells several glycoproteins with molecular weights between 20 and 230 kDa were affinity-precipitated using immobilised MAG. The interactions of these proteins with MAG were sialic acid-dependent and specific for MAG. (+info)

Carbohydrate on human factor VIII/von Willebrand factor. Impairment of function by removal of specific galactose residues. (5/3160)

Human factor VIII/von Willebrand factor protein containing 120 +/- 12 nmol of sialic acid and 135 +/- 13 nmol of galactose/mg of protein was digested with neuraminidase. The affinity of native factor VIII/von Willebrand factor and its asialo form for the hepatic lectin that specifically binds asialoglycoproteins was assessed from in vitro binding experiments. Native factor VIII/von Willebrand factor exhibited negligible affinity while binding of the asialo derivative was comparable to that observed for asialo-alpha1-acid glycoprotein. Incubation of asialo-factor VIII/von Willebrand factor with Streptococcus pneumoniae beta-galactosidase removed only 62% of the galactose but abolished binding to the purified hepatic lectin. When the asialo derivative was incubated with purified beta-D-galactoside alpha2 leads to 6 sialyltransferase and CMP-[14C]NeuAc, only 61% of the galactose incorporated [14C]NeuAc. From the known specificites of these enzymes, it is concluded that galactose residues important in lectin binding are present in a terminal Gal/beta1 leads to 4GlcNAc sequence on asialo-factor VIII/von Willebrand factor. The relative ristocetin-induced platelet aggregating activity of native, asialo-, and agalacto-factor VIII/von Willebrand factor was 100:38:12, respectively, while procoagulant activity was 100:100:103. (+info)

Tandem amino acid repeats from Trypanosoma cruzi shed antigens increase the half-life of proteins in blood. (6/3160)

Proteins containing amino acid repeats are widespread among protozoan parasites. It has been suggested that these repetitive structures act as immunomodulators, but other functional aspects may be of primary importance. We have recently suggested that tandem repeats present in Trypanosoma cruzi trans-sialidase stabilize the catalytic activity in blood. Because the parasite releases trans-sialidase, this delayed clearance of the enzyme might have implications in vivo. In the present work, the ability of repetitive units from different T. cruzi molecules in stabilizing trans-sialidase activity in blood was evaluated. It is shown that repeats present on T. cruzi shed proteins (antigens 13 and Shed-Acute-Phase-Antigen [SAPA]) increase trans-sialidase half-life in blood from 7 to almost 35 hours. Conversely, those repeats present in intracellular T. cruzi proteins only increase the enzyme half-life in blood up to 15 hours. Despite these results, comparative analysis of structural and catalytic properties of both groups of chimeric enzymes show no substantial differences. Interestingly, antigens 13 and SAPA also increase the persistence in blood of chimeric glutathione S-transferases, thus suggesting that this effect is inherent to these repeats and independent of the carrier protein. Although the molecular basis of this phenomenon is still uncertain, its biotechnological potential can be envisaged. (+info)

Amino acid substitutions in a conserved region in the stalk of the Newcastle disease virus HN glycoprotein spike impair its neuraminidase activity in the globular domain. (7/3160)

The ectodomain of the paramyxovirus haemagglutinin-neuraminidase (HN) glycoprotein spike can be divided into two regions: a membrane-proximal, stalk-like structure and a terminal globular domain. The latter contains all the antibody recognition sites of the protein, as well as its receptor recognition and neuraminidase (NA) active sites. These two activities of the protein can be separated by monoclonal antibody functional inhibition studies and mutations in the globular domain. Herein, we show that mutation of several conserved residues in the stalk of the Newcastle disease virus HN protein markedly decrease its NA activity without a significant effect on receptor recognition. Thus, mutations in the stalk, distant from the NA active site in the globular domain, can also separate attachment and NA. These results add to an increasing body of evidence that the NA activity of this protein is dependent on an intact stalk structure. (+info)

Ortho- and paramyxoviruses from migrating feral ducks: characterization of a new group of influenza A viruses. (8/3160)

Ortho- and parainfluenza viruses isolated from the cloacas of migrating feral ducks shot on the Mississippi flyway included three strains of influenza. A virus (Hav6 Nav1, Hav6 Nl, Hav7 Neq2) as well as Newcastle disease virus. One influenza virus, A/duck/Memphis/546/74, possessed Hav3 haemagglutinin, but the neuraminidase was not inhibited by any of the known influenza reference antisera. The neuraminidase on this virus was related to the neuraminidases on A/duck/GDR/72 (H2 N?), A/turkey/Ontario/7732/66 (Hav 5 N?), A/duck/Ukraine/1/60 (Hav3 N?) and A/turkey/Wisconsin/68. We therefore propose that the neuraminidase on this group of influenza viruses be designated Nav6. The A/duck/Memphis/546/74 influenza virus caused an ocular discharge in 1 of 5 ducks and was shed in faeces for 10 days; it was stable in faecal samples for up to 3 days at 20 degrees C. These results suggest that ecological studies on influenza in avian species should include attempts to isolate virus from faeces. Faecal-oral transmission is an attractive explanation for the spread of influenza virus from feral birds to other animals. (+info)

... researchers have developed influenza neuraminidase inhibitors which effectively block the influenza neuraminidase and ... The influenza virus protein viral neuraminidase is a six-bladed beta-propeller protein whose active form is a tetramer. It is ... The beta-propeller domain of the influenza virus neuraminidase are often used for drug design. Through study of this enzyme, ... Matrosovich MN, Matrosovich TY, Gray T, Roberts NA, Klenk HD (November 2004). "Neuraminidase is important for the initiation of ...

https://en.wikipedia.org/wiki/Beta-propeller

Hinek A, Bodnaruk TD, Bunda S, Wang Y, Liu K (Oct 2008). "Neuraminidase-1, a subunit of the cell surface elastin receptor, ... The elastin receptor complex includes S-Gal, neuraminidase and Cathepsin A. When elastin-derived peptides bind to the S-Gal ... Hinek A, Pshezhetsky AV, von Itzstein M, Starcher B (Feb 2006). "Lysosomal sialidase (neuraminidase-1) is targeted to the cell ... The enzymatic activity of neuraminidase in the elastin receptor complex is involved in the release of tropoelastin molecules ...

https://en.wikipedia.org/wiki/GLB1

Parainfluenza hemagglutinin-neuraminidase: a type of hemagglutinin-neuraminidase produced by parainfluenza which is closely ... Cold agglutinin disease Hemagglutination assay Neuraminidase Influenza hemagglutinin (HA) Agglutination Henry, R.; Murphy, FA ... Wikipedia (August 3, 2019) [January 5, 2009]. "Parainfluenza hemagglutinin-neuraminidase". www.wikipedia.com. Retrieved Nov 7, ... Oct 24, 2018) [2018]. ""Etymologia: Hemagglutinin and Neuraminidase"". Emerging Infectious Diseases. 24 (10): 1849. doi:10.3201 ...

https://en.wikipedia.org/wiki/Hemagglutinin

They discovered neuraminidase. He was elected a Fellow of the Australian Academy of Science in 1954. On his retirement in 1959 ...

https://en.wikipedia.org/wiki/Alfred_Gottschalk_(biochemist)

ISBN 978-1-4160-2973-1. van der Spoel, A; Bonten E; d'Azzo A (Mar 1998). "Transport of human lysosomal neuraminidase to mature ... 1991). "Combined deficiency of beta-galactosidase and neuraminidase: natural history of the disease in the first 18 years of an ... This gene encodes a glycoprotein that associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex ... It is protective for β-galactosidase and neuraminidase. Deficiencies in this gene are linked to multiple forms of ...

https://en.wikipedia.org/wiki/Cathepsin_A

Penzel R, Uhl J, Kopitz J, Beck M, Otto HF, Cantz M (2001). "Splice donor site mutation in the lysosomal neuraminidase gene ... Sialidase 1 (lysosomal sialidase), also known as NEU1 is a mammalian lysosomal neuraminidase enzyme which in humans is encoded ... van der Spoel A, Bonten E, d'Azzo A (Mar 1998). "Transport of human lysosomal neuraminidase to mature lysosomes requires ... Bonten E, van der Spoel A, Fornerod M, Grosveld G, d'Azzo A (1997). "Characterization of human lysosomal neuraminidase defines ...

https://en.wikipedia.org/wiki/NEU1

Neuraminidase inhibitors. Overall the benefits of neuraminidase inhibitors in those who are otherwise healthy do not appear to ... Hemagglutinin and neuraminidase molecules cluster into a bulge in the cell membrane. The vRNA and viral core proteins leave the ... The hemagglutinin (HA) and neuraminidase (NA) proteins are shown on the surface of the particle. The viral RNAs that make up ... Hemagglutinin (HA) and neuraminidase (NA) are the two large glycoproteins on the outside of the viral particles. HA is a lectin ...

https://en.m.wikipedia.org/wiki/Influenza

It is a neuraminidase inhibitor and was developed by the Australian biotech firm Biota Holdings. It was licensed to Glaxo in ... Zanamivir works by binding to the active site of the neuraminidase protein, rendering the influenza virus unable to escape its ... Zanamivir, a transition-state analogue inhibitor of neuraminidase, was the result. As Biota was a small company, it did not ... Its strategy relied on the availability of the structure of influenza neuraminidase by X-ray crystallography. It was also known ...

https://en.wikipedia.org/wiki/Zanamivir

Aisaka, Kazuo; Uwajima, Takayuki (1987). "Production of neuraminidase byMicromonospora viridifaciens". FEMS Microbiology ... and characterization of neuraminidase from Micromonospora viridifaciens". Agricultural and Biological Chemistry. 55 (4): 997- ... "Contribution of the active site aspartic acid to catalysis in the bacterial neuraminidase from Micromonospora viridifaciens". ... and characterization of the Micromonospora viridifaciens neuraminidase gene in Streptomyces lividans". J Bacteriol. 174 (21): ...

https://en.wikipedia.org/wiki/Micromonospora_viridifaciens

Segment 6 encodes NA (neuraminidase). About 100 molecules of neuraminidase are needed to make one virion. Segment 7 encodes two ... protein and a type 1 neuraminidase (N) protein. There are 18 known types of hemagglutinin and 11 known types of neuraminidase, ... The neuraminidase, on the other hand, is critical for the subsequent release of the daughter virus particles created within the ... N = neuraminidase, an enzyme that cleaves the glycosidic bonds of the monosaccharide sialic acid (previously called neuraminic ...

https://en.wikipedia.org/wiki/Influenza_A_virus

Royal, Jr., George C.; Nandedkar, Arvind K. N.; Sampson, Calvin C.; Faggett, Timothy (1984). "Neuraminidase Production by ...

https://en.wikipedia.org/wiki/George_C._Royal

Yamashita M, Tomozawa T, Kakuta M, Tokumitsu A, Nasu H, Kubo S (January 2009). "CS-8958, a prodrug of the new neuraminidase ... Laninamivir (CS-8958) is a neuraminidase inhibitor that is a drug used for the treatment and prophylaxis of Influenzavirus A ... It is a long-acting neuraminidase inhibitor administered by nasal inhalation. Laninamivir was approved for influenza treatment ... Samson, M; Pizzorno, A; Abed, Y; Boivin, G (May 2013). "Influenza virus resistance to neuraminidase inhibitors". Antiviral ...

https://en.wikipedia.org/wiki/Laninamivir

Colman determined the three-dimensional structure of the influenza virus neuraminidase and, in one of the earliest cases of ... "Influenza virus neuraminidase: Structure, antibodies, and inhibitors". Protein Science. 3 (10): 1687-96. doi:10.1002/pro. ... "Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution". Nature. 303 (5912): 35-40. doi: ... "Three-dimensional structure of a complex of antibody with influenza virus neuraminidase". Nature. 326 (6111): 358-63. doi: ...

https://en.wikipedia.org/wiki/Peter_Colman

... neuraminidase hydrolyses sialic acid residues from glycoproteins; NanM is a sialic acid mutarotase, involved in efficient ...

https://en.wikipedia.org/wiki/Kelch_motif

On the other hand, a few strains resistant to neuraminidase inhibitors have emerged and circulated in the absence of much use ... The main classes of antiviral drugs used against influenza are neuraminidase inhibitors, such as zanamivir and oseltamivir, ... Lackenby A, Thompson CI, Democratis J (December 2008). "The potential impact of neuraminidase inhibitor resistant influenza". ... neuraminidase (NA) were to acquire the tamiflu-resistance (His274Tyr) mutation which is currently widespread in seasonal H1N1 ...

https://en.wikipedia.org/wiki/Influenza_treatment

Preliminary tests have shown it to be an effective neuraminidase inhibitor against the influenza A virus subtype H1N1. Huang, ... neuraminidase inhibitors from Vitis amurensis". Food Chemistry. 124 (2): 437-443. doi:10.1016/j.foodchem.2010.06.049. ISSN 0308 ...

https://en.wikipedia.org/wiki/Amurensin_K

Neuraminidase are enzymes that break glycosidic breaks glycosidic linkages. The size and surface molecules presented on of the ... In the case of the influenza virosome, the glycoproteins are antigen, haemagglutinin, and neuraminidase. Antigens are molecules ... and neuraminidase (NA) intercalated in the phospholipid bilayer membrane. They have a typical mean diameter of 150 nm. ...

https://en.wikipedia.org/wiki/Virosome

... is a neuraminidase inhibitor isolated from the fungus Phellinus linteus. Yeom, JH; Lee, IK; Ki, DW; Lee, MS; Seok ... SJ; Yun, BS (2012). "Neuraminidase Inhibitors from the Culture Broth of Phellinus linteus". Mycobiology. 40 (2): 142-4. doi: ...

https://en.wikipedia.org/wiki/Hypholomine_B

... is a neuraminidase inhibitor, a competitive inhibitor of influenza's neuraminidase enzyme. The enzyme cleaves the ... May 2016). "Neuraminidase inhibitors for influenza: a systematic review and meta-analysis of regulatory and mortality data". ... Wang K, Shun-Shin M, Gill P, Perera R, Harnden A (April 2012). Harnden A (ed.). "Neuraminidase inhibitors for preventing and ... April 2014). "Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children". The Cochrane ...

https://en.wikipedia.org/wiki/Oseltamivir

... is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby ... Thorlund K, Awad T, Boivin G, Thabane L (May 2011). "Systematic review of influenza resistance to the neuraminidase inhibitors ... McKimm-Breschkin JL (January 2013). "Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance". ... a S247N neuraminidase mutation) giving some resistance to oseltamivir and zanamivir, but no significant reduction in ...

https://en.wikipedia.org/wiki/Peramivir

It attaches to CD46 using a dead neuraminidase domain. Pan CH, Jimenez GS, Nair N, et al. (August 2008). "Use of Vaxfectin ...

https://en.wikipedia.org/wiki/Measles_hemagglutinin

Bardeletti G, Kessler N, Aymard-Henry M (1975). "Morphology, biochemical analysis and neuraminidase activity of rubella virus ...

https://en.wikipedia.org/wiki/Rubella_virus

NA codes for neuraminidase, an antigenic glycosylated enzyme found on the surface of the influenza viruses. It facilitates the ... N1 stands for the first of several known types of the protein neuraminidase. Other examples include: A/duck/Hong Kong/308/78( ... The hemagglutinin (HA) and neuraminidase (NA) RNA strands specify the structure of proteins that are most medically relevant as ... and Consensus Screening of Avian Influenza H5N1 Wild-Type Neuraminidase and of the Oseltamivir-Resistant H274Y Variant". J. ...

https://en.wikipedia.org/wiki/Influenza_A_virus_subtype_H5N1

Laborda, Pedro; Wang, Su-Yan; Voglmeir, Josef (2016-11-11). "Influenza Neuraminidase Inhibitors: Synthetic Approaches, ... synthesis of the anti-influenza neuraminidase inhibitor oseltamivir phosphate (Tamiflu)". J. Org. Chem. 66: 2044-51. doi: ...

https://en.wikipedia.org/wiki/Oseltamivir_total_synthesis

Wagner R, Matrosovich M, Klenk HD (May 2002). "Functional balance between haemagglutinin and neuraminidase in influenza virus ...

https://en.wikipedia.org/wiki/Tilapia_tilapinevirus

Hemagglutinin-neuraminidase (HN) is a single protein that induces hemagglutination and possesses neuraminidase (sialidase) ... Most likely, viral hemagglutinin-neuraminidase protein, highly contributes to the effect (see "Neuraminidase (NA) removal of ... Neuraminidase (NA), a subunit of the HN protein, binds to and cleaves sialic acid from the cell surface. NA also promotes cell ... Neuraminidase (NA) is a sialidase that cleaves and removes sialic acid from the surface of a host cell. This cleavage promotes ...

https://en.wikipedia.org/wiki/Murine_respirovirus

Neuraminidase is a type of glycoside hydrolase enzyme which helps to move the virus particles through the infected cell and ... It is an orthomyxovirus that contains the glycoproteins haemagglutinin and neuraminidase. For this reason, they are described ... Oseltamivir (trade name Tamiflu) and zanamivir (Relenza) are two neuraminidase inhibitors (antiviral medications) currently ... but the neuraminidase (NA) and matrix protein (M) genes resembled versions present in European swine flu isolates. The six ...

https://en.wikipedia.org/wiki/Influenza_A_virus_subtype_H1N1

In particular, he designed and carried out critical studies evaluating the value of the neuraminidase inhibitors now in use for ... Monto, Arnold (2006). "Neuraminidase inhibitor susceptibility network position statement: antiviral resistance in influenza A/ ... How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?". mBio. 9 (2). doi:10.1128/mBio.02332-17. ... 2009 Co-chair Neuraminidase Inhibitor Susceptibility Network, 2006-2013 Co-chair, Infectious Disease Society of America ...

https://en.wikipedia.org/wiki/Arnold_Monto

HN (Hemagglutinin-neuraminidase) attachment proteins occur in respiroviruses, rubulaviruses and avulaviruses. These possess ... Attachment proteins with neither haemagglutination nor neuraminidase activity are designated G (glycoprotein). These occur in ... both haemagglutination and neuraminidase activity, which cleaves sialic acid on the cell surface, preventing viral particles ...

https://en.wikipedia.org/wiki/Paramyxoviridae

The best-known neuraminidase is the viral neuraminidase, a drug target for the prevention of the spread of influenza infection ... Neuraminidase enzymes are glycoside hydrolase enzymes that cleave the glycosidic linkages of neuraminic acids. Neuraminidase ... Main article: Neuraminidase inhibitors. Neuraminidase inhibitors are useful for combating influenza infection: zanamivir, ... Main article: Viral neuraminidase. Influenza neuraminidase is a mushroom-shaped projection on the surface of the influenza ...

https://en.wikipedia.org/wiki/Neuraminidase

Neuraminidase is an hydrolase enzyme that breaks down glycosidic bonds. It is found on the surface of the Orthomyxoviridae1 ... Neuraminidase is an hydrolase enzyme that breaks down glycosidic bonds. It is found on the surface of the Orthomyxoviridae1 ... Neuraminidase, along with hemagglutinin, are the two proteins on the surface of the virus recognized by the human body as ... The first hint that neuraminidase existed was unearthed in the 1940s, when George Hirst found that when allantoic fluid2 ...

https://everything2.com/title/neuraminidase

Types include: Mumps hemagglutinin-neuraminidase Parainfluenza hemagglutinin-neuraminidase Hemagglutinin-neuraminidase ... Hemagglutinin-neuraminidase refers to a single viral protein that has both hemagglutinin and (endo) neuraminidase EC 3.2.1.18 ... Its neuraminidase domain has the CAZy designation glycoside hydrolase family 83 (GH83). It does show a structural similarity to ... Hemagglutinin-neuraminidase allows the virus to stick to a potential host cell, and cut itself loose if necessary. ...

https://en.wikipedia.org/wiki/Hemagglutinin-neuraminidase

neuraminidase synonyms, neuraminidase pronunciation, neuraminidase translation, English dictionary definition of neuraminidase ... Related to neuraminidase: sialic acid, Neuraminidase inhibitor. neu·ra·min·i·dase. (no͝or′ə-mĭn′ĭ-dās′, -dāz′, nyo͝or′-). n.. A ... The neuraminidases of HiNi viruses also are similar to a neuraminidase in the current vaccine strain.. FDA panel defers ... Neuraminidase - definition of neuraminidase by The Free Dictionary https://www.thefreedictionary.com/neuraminidase ...

https://www.thefreedictionary.com/neuraminidase

Neuraminidase inhibitor drugs improved the survival of children with influenza when they were given the drugs within the first ... Neuraminidase inhibitor (NAI) drugs improved survival of children with influenza when they were given the drugs within the ... Cite this: Neuraminidase Inhibitors Improve Survival in Kids With Flu - Medscape - Nov 25, 2013. ...

https://www.medscape.com/viewarticle/814929

US Oral Neuraminidase Study Group. . Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute ... Neuraminidase Inhibitors for Critically Ill Children With Influenza. Janice K. Louie, Samuel Yang, Michael C. Samuel, Timothy M ... neuraminidase inhibitor. OR - odds ratio. pH1N1 - influenza A(H1N1)pdm09. Whats Known on This Subject:. Few data on treating ... Treatment with neuraminidase inhibitors for critically ill patients with influenza A (H1N1)pdm09. Clin Infect Dis. 2012;55(9): ...

http://pediatrics.aappublications.org/content/132/6/e1539

Introduction of neuraminidase inhibitor zanamivir * S Handysides, W Kiehl, S Salmaso, K Ekdahl, R Hemmer, T Hovi, B Iversen, E ... Introduction of neuraminidase inhibitor zanamivir. Euro Surveill. 1999;3(41):pii=1318. https://doi.org/10.2807/esw.03.41.01318- ...

http://www.eurosurveillance.org/content/10.2807/esw.03.41.01318-en

This Neuraminidase catalyzes the hydrolysis of α2-3, α2-6, and α2-8 linked N-acetyl-neuraminic acid residues from glycoproteins ... Neuraminidase is the common name for Acetyl-neuraminyl hydrolase (Sialidase). ... α2-3,6,8 Neuraminidase α2-3,6,8 Neuraminidase catalyzes the hydrolysis of α2-3, α2-6, and α2-8 linked sialic acid residues from ... Neuraminidase is the common name for Acetyl-neuraminyl hydrolase (Sialidase). This Neuraminidase catalyzes the hydrolysis of α2 ...

https://www.neb.com/products/p0720-a2-3-6-8-neuraminidase

Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance. Influenza Other Respir Viruses. 2013 Jan;7( ... Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance. Influenza Other Respir Viruses. 2013 Jan;7( ... Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance. Influenza Other Respir Viruses. 2013 Jan;7( ... Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance.. McKimm-Breschkin JL1. ...

https://www.ncbi.nlm.nih.gov/pubmed/23279894

The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

http://www.rcsb.org/pdb/protein/P03474

1980) Gangliosides, Neuraminidase and Sialyltransferase at the Nerve Endings. In: Svennerholm L., Mandel P., Dreyfus H., Urban ...

https://link.springer.com/chapter/10.1007/978-1-4684-7844-0_25

Antibodies which inhibit the enzyme limit the infection, but antigenic variation of the neuraminidase renders it ineffective in ... It is the enzyme neuraminidase, projecting from the surface of influenza virus particles, which allows the virus to leave ... The neuraminidase of influenza virus Proteins. 1989;6(4):341-56. doi: 10.1002/prot.340060402. ... It is the enzyme neuraminidase, projecting from the surface of influenza virus particles, which allows the virus to leave ...

https://pubmed.ncbi.nlm.nih.gov/2482974/?dopt=Abstract

Different Inhibitory Potencies of Oseltamivir Carboxylate, Zanamivir, and Several Tannins on Bacterial and Viral Neuraminidases ... and bacterial Vibrio cholerae neuraminidase (VCNA). Compared to the positive controls, all tested polyphenols displayed a weak ... showed synergistic inhibitory effects on the bacterial neuraminidase. Co-crystal structures of VCNA with oseltamivir ... the inhibitory potency of plant tannins versus clinically used inhibitors on both a viral and a bacterial model neuraminidase b ...

https://www.rcsb.org/structure/6EKS

Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III.. Lawrence MC1, Borg NA, Streltsov VA, ... The three-dimensional structure of the haemagglutinin-neuraminidase (HN) from a human parainfluenza virus is described at ca ... a dimer of beta-propellers and find no evidence for spatially separated sites performing the receptor-binding and neuraminidase ...

https://www.ncbi.nlm.nih.gov/pubmed/14729348?dopt=Abstract

Two neuraminidase inhibitors for treatment of influenza. Download Prime PubMed App to iPhone, iPad, or Android ... 1999). Two neuraminidase inhibitors for treatment of influenza. The Medical Letter On Drugs and Therapeutics, 41(1063), 91-3. ... "Two Neuraminidase Inhibitors for Treatment of Influenza." The Medical Letter On Drugs and Therapeutics, vol. 41, no. 1063, 1999 ... Two Neuraminidase Inhibitors for Treatment of Influenza. Med Lett Drugs Ther. 1999 Oct 8;41(1063):91-3. PubMed PMID: 10535051. ...

https://www.unboundmedicine.com/medline/citation/10535051/Two_neuraminidase_inhibitors_for_treatment_of_influenza_

Positive Regulation of Insulin Signaling by Neuraminidase 1. Larbi Dridi, Volkan Seyrantepe, Anne Fougerat, Xuefang Pan, Éric ... Positive Regulation of Insulin Signaling by Neuraminidase 1. Larbi Dridi, Volkan Seyrantepe, Anne Fougerat, Xuefang Pan, Éric ... Positive Regulation of Insulin Signaling by Neuraminidase 1 Message Subject (Your Name) has forwarded a page to you from ...

https://diabetes.diabetesjournals.org/content/62/7/2338.figures-only

There are no specific protocols for Anti-Swine H1N1 Neuraminidase antibody (ab91643). Please download our general protocols ...

http://www.abcam.com/swine-h1n1-neuraminidase-antibody-ab91643-protocols.html

NHS Evidence on Neuraminidase Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research ...

http://www.ganfyd.org/index.php?title=Neuraminidase

The non-viral neuraminidase is called Sialidase.. *endo-neuraminidase is a phage neuraminidase which cleaves α-2,8-polysialic ... Neuraminidase or sialidase (NAN) is a viral neuraminidase which cleaves the glycosidic bonds of neuraminic acid[1]. ... Treatments:Neuraminidase Inhibitor Pharmacokinetics References. . Relevance The viral NAN is a drug target for prevention of ... Pseudaminidase is a Pseudomonas aeruginosa neuraminidase. *Trans-sialidase transfers sialic acid from Trypanosoma cruzi to a ...

http://proteopedia.org/wiki/index.php/Sialidase

An important function of the influenza virus neuraminidase protein is to remove sialic acid from glycoproteins, allowing virus ... I have written about the HA and its function during infection (article one and two) but not about the neuraminidase (NA, red) ... Years ago Peter Palese showed that influenza virus forms aggregates at the cell surface when the viral neuraminidase is ...

http://www.virology.ws/2013/11/05/the-neuraminidase-of-influenza-virus/

Benefit of oral neuraminidase inhibitor oseltamivir in natural influenza. Euro Surveill. 2000;4(8):pii=1652. https://doi.org/ ...

https://www.eurosurveillance.org/content/10.2807/esw.04.08.01652-en

... is a traditional Chinese herb which inhibits the viral enzyme neuraminidase in a fashion comparable to that of Tamiflu. ... Radix Isatidis (Woad) is a traditional Chinese herb which inhibits the viral enzyme neuraminidase in a fashion comparable to ... In this paper, the in vitro inhibitory action of Radix Isatidis on neuraminidase (NA) was investigated by fluorometric assay ...

https://www.greenmedinfo.com/article/radix-isatidis-woad-traditional-chinese-herb-which-inhibits-viral-enzyme-neura

The data is inconclusive as to whether or not neuraminidase inhibitors are effective at preventing and treating influenza in ... Problem Substances : Neuraminidase inhibitors : CK(20) : AC(1), Oseltamivir (trade name Tamiflu) : CK(223) : AC(33), Zanamivir ... BACKGROUND: Neuraminidase inhibitors (NI) are recommended for use against influenza and its complications in inter-pandemic ... The data is inconclusive as to whether or not neuraminidase inhibitors are effective at preventing and treating influenza in ...

https://greenmedinfo.com/article/data-inconclusive-whether-or-not-neuraminidase-inhibitors-are-effective-preven

Rabbit polyclonal Influenza A Neuraminidase 1 antibody. Validated in ELISA and tested in Influenza A. Immunogen corresponding ... Primary - Rabbit Anti-Influenza A Neuraminidase 1 antibody (ab119972) ELISA Secondary - Goat Anti-Rabbit IgG H&L (HRP) ( ... ab119972 recognises the neuraminidase protein from seasonal Influenza A/Georgia/20/2006 (H1N1) (Genbank accession no. ACA33620 ... Synthetic peptide corresponding to the Neuraminidase protein from seasonal Influenza A/Georgia/20/2006 (H1N1) (Genbank ...

https://www.abcam.com/influenza-a-neuraminidase-1-antibody-ab119972.html

The treatment of influenza is mainly based on the administration of neuraminidase inhibitors. The neuraminidase inhibitors ... A neuraminidase located on the surface of the virus plays an important role in viral reproduction by contributing to the ... In order to create more potent neuraminidase inhibitors and fight against the surge in resistance resulting from naturally- ... occurring mutations, these anti-influenza drugs have been used as templates for the development of new neuraminidase inhibitors ...

http://www.mdpi.com/1420-3049/21/11/1513

The only universally conserved sequence amongst all influenza A viral neuraminidase (NA) is located between amino acids 222-230 ... Universal anti-neuraminidase antibody inhibiting all influenza A subtypes Antiviral Res. 2013 Nov;100(2):567-74. doi: 10.1016/j ... The only universally conserved sequence amongst all influenza A viral neuraminidase (NA) is located between amino acids 222-230 ...

https://pubmed.ncbi.nlm.nih.gov/24091204/?dopt=Abstract

Browse our Seasonal H1N1 Neuraminidase product catalog backed by our Guarantee+. ... Seasonal H1N1 Neuraminidase products available through Novus Biologicals. ...

https://www.novusbio.com/common-name/seasonal-h1n1-neuraminidase

Hemagglutinin-neuraminidaseAdd BLAST. 565. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ... Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid ... sp,P04850,HN_PIV5 Hemagglutinin-neuraminidase OS=Parainfluenza virus 5 (strain W3) GN=HN PE=1 SV=1 ... Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.Curated. ,p>UniProtKB Keywords constitute a ,a href="http:// ...

http://www.uniprot.org/uniprot/P04850

Neuraminidase is the common name for Acetyl-neuraminyl hydrolase (Sialidase). (neb.com)
Neuraminidase or sialidase (NAN) is a viral neuraminidase which cleaves the glycosidic bonds of neuraminic acid [1] . (proteopedia.org)
The non-viral neuraminidase is called Sialidase . (proteopedia.org)
The Amplex® Red Neuraminidase (Sialidase) Assay Kit provides a sensitive and simple method for detecting neuraminidase activity in serum and in purified enzyme systems using either a fluorescence microplate reader or fluorometer. (thermofisher.com)
Neuraminidase (also known as sialidase) is a very common enzyme that hydrolyzes terminal sialic acid residues on polysaccharide chains, most often exposing a galactose residue. (thermofisher.com)
The Amplex® Red Neuraminidase (Sialidase) Assay Kit provides an ultrasensitive method for detecting neuramimidase activity. (thermofisher.com)
Sandhoff K., Pallmann B., Wiegandt H., Ziegler W. (1978) Studies on Bovine Brain Membrane-Bound Neuraminidase (Sialidase). (springer.com)
Either of two types of mucolipidosis caused by a deficiency of the enzyme neuraminidase (formerly called sialidase) and characterized by myoclonic seizures, cherry-red maculas in the retina with visual impairment, enlarged liver and spleen, and intellectual disability in the more severe type. (thefreedictionary.com)
a neuronal storage disease of children caused by a deficiency of the enzyme sialidase (neuraminidase). (thefreedictionary.com)
A condition caused by an isolated defect of alpha-N-acetyl neuraminidase (sialidase) in leukocytes and fibroblasts and an increase of sialyloligosaccharide in the urine. (thefreedictionary.com)

Recent emergence of oseltamivir and zanamivir resistant human influenza A( H1N1 ) H274Y has emphasized the need for suitable expression systems to obtain large quantities of highly pure and stable, recombinant neuraminidase through two separate artificial tetramerization domains that facilitate the formation of catalytically active neuraminidase homotetramers from yeast and Staphylothermus marinus, which allow for secretion of FLAG-tagged proteins and further purification. (wikipedia.org)
A range of flavan-3-ols, ellagitannins and chemically defined proanthocyanidin fractions was evaluated in comparison to oseltamivir carboxylate and zanamivir for their inhibitory activities against viral influenza A (H1N1) and bacterial Vibrio cholerae neuraminidase (VCNA). (rcsb.org)
ab119972 recognises the neuraminidase protein from seasonal Influenza A/Georgia/20/2006 (H1N1) (Genbank accession no. (abcam.com)
Synthetic peptide corresponding to the Neuraminidase protein from seasonal Influenza A/Georgia/20/2006 (H1N1) (Genbank accession no. (abcam.com)
Swine Influenza Virus PA and Neuraminidase Gene Reassortment into Human H1N1 Influenza Virus Is Associated with an Altered Pathogenic Phenotype Linked to Increased MIP-2 Expression. (jcvi.org)
Sharma DK, Rawat AK, Srivastava S, Srivastava R, Kumar A (2010) Comparative Sequence Analysis on Different Strains of Swine Influenza Virus Sub-type H1N1 for Neuraminidase and Hemagglutinin. (omicsonline.org)
The H1N1 amino acid sequences of neuraminidase (GenBank Acc. (omicsonline.org)
During the H1N1 pandemic in 2009-2010 neuraminidase inhibitors (NAI) were recommended as empiric treatment for suspected cases of H1N1. (lasvegasemr.com)
Antigenic Drift of Hemagglutinin and Neuraminidase in seasonal H1N1 influenza Viruses from Saudi Arabia in 2014-2015. (physiciansweekly.com)
Gangul Sayak, Mazumder Manjita, Basu Protip, Roy Paushali, Mitra Sayani, Datta Abhijit: In silico screening of herbal and nanoparticle lead compounds for effectivity against H5N1, H1N1 neuraminidase and telomerase. (biomedcentral.com)
Neuraminidase amino acids 149 and 347 determine the infectivity and oseltamivir sensitivity of pandemic influenza A/H1N1 (2009) and avian influenza A/H5N1. (semanticscholar.org)
Pandemic influenza A/H1N1 (2009) and avian influenza A/H5N1 neuraminidase (NA) differ at two critical residues, positions 149 and 347. (semanticscholar.org)
Oseltamivir resistance depends on the position 273 amino acid of neuraminidase of the type A influenza virus (H1N1), circulating in human population]. (semanticscholar.org)

these projections include the mushroom-shaped neuraminidase proteins, among many others. (everything2.com)
Neuraminidase, along with hemagglutinin , are the two proteins on the surface of the virus recognized by the human body as antigen s, and they are also commonly targeted by antiviral drugs (such as zanamivir and oseltamivir ). (everything2.com)
I have written about the HA and its function during infection (article one and two ) but not about the neuraminidase (NA, red) or M2 (purple) proteins. (virology.ws)
Image of influenza virus showing hemagglutinin (blue) and neuraminidase (red) proteins on the surface of the virus. (cdc.gov)
Neuraminidase is one of three different viral proteins embedded in the lipid membrane of influenza virus (NA is blue in the illustration at left). (virology.ws)
Studies employing monoclonal antibodies have revealed several conformational epitopes of fusion (F) and hemagglutinin-neuraminidase (HN) proteins, and one linear epitope composed of 345 to 353 amino acid residues of the HN protein has been defined ( 5 , 7 - 9 , 22 , 28 ). (asm.org)
Three of these proteins are expressed on the plasma membrane and incorporated in the envelope of the budding virion: hemagglutinin (HA), neuraminidase (NA), and an ion channel (M2). (asm.org)
The first was finding two networks of co-mutations that may po-tentially affect the current flu-drug binding sites on neuraminidase (NA), one of the two surface proteins of flu virus. (scirp.org)
In the N-terminus there is a cysteine-rich domain containing a stretch of 332 amino acids nearly 30% identical to the Clostridium perfringens neuraminidase, three repeat motifs highly conserved in bacterial and viral neuraminidases, and two segments with similarity to the YWTD repeats found in the low density lipoprotein (LDL) receptor and in other vertebrate and invertebrate proteins. (rupress.org)
Antigenic drift of the hemagglutinin (HA) and neuraminidase (NA) proteins of influenza virus cause decrease in vaccine efficacy. (physiciansweekly.com)
Identification of Residues That Affect Oligomerization and/or Enzymatic Activity of Influenza Virus H5N1 Neuraminidase Proteins. (semanticscholar.org)
The surface of neuraminidase is decorated with several polysaccharide chains that are similar to the polysaccharide chains that decorate our own cell surface proteins. (creativebiomart.net)

The 3-dimensional structure of the epitopes was obtained by X-ray diffraction methods using crystals of neuraminidase complexed with monoclonal antibody Fab fragments. (nih.gov)
The crystal structure of two mutants showed that the change in structure was restricted to that particular sidechain, but the change in the epitope was sufficient to abolish antibody binding even though it is known in one case that 21 other amino acids on the neuraminidase are in contact with the antibody. (nih.gov)
We have identified and characterized an H5N1 neuraminidasespecific monoclonal antibody which specifically inhibits N1 neuraminidase activity of highly pathogenic avian influenza (HPAI) strains from clades 1 and 2. (curehunter.com)
Q neuraminidases were measured before and after immunization, the antibody levels were increased following immunization, however no relationship was detected between antibody levels and the survival time of the individual mice. (bl.uk)
This antibody detects Neuraminidase. (acris-antibodies.com)
Influenza B Virus Neuraminidase antibody LS-C83326 is an unconjugated mouse monoclonal antibody to influenza virus Influenza B Virus Neuraminidase. (lsbio.com)

Hemagglutinin-neuraminidase refers to a single viral protein that has both hemagglutinin and (endo) neuraminidase EC 3.2.1.18 activity. (wikipedia.org)
One viral protein, an enzyme called neuraminidase , is required for the bundle to unglue itself so that individual virus particles can infect other cells. (thefreedictionary.com)
In support of earlier work on the structure of the homologous protein from the avian pathogen Newcastle disease virus (NDV), we observe a dimer of beta-propellers and find no evidence for spatially separated sites performing the receptor-binding and neuraminidase functions of the protein. (nih.gov)
The other influenza virus surface protein, neuraminidase (referring to brain lipids from which it was first derived) is a virus receptor-destroying enzyme that removes its substrate, sialic acids, from infected cell surfaces so that newly made progeny viruses are released to infect additional cells. (cdc.gov)
The aim of this project was to characterise a neuraminidase from Streptococcus pneumoniae by relating its amino acid sequence to the enzymatic activity of the protein, leading to the production of mutated neuraminidases that could be tested as protective immunogens. (bl.uk)
Paramyxoviruses, including HPIVs, possess an envelope protein hemagglutinin-neuraminidase (HN) that has receptor-cleaving as well as receptor-binding activity where the two activities reside on the same glycoprotein unlike influenza which carries hemagglutinin and neuraminidase activities as individual glycoproteins. (functionalglycomics.org)
Funning, T.G., Reid, A.H., Taubenberger, J.K.: Influenza A virus neuraminidase: regions of the protein potentially involved in virus-host interactions. (springer.com)
Its neuraminidase (NA) gene encodes a protein that appears to be highly divergent from all known influenza NAs and was assigned as a new subtype N10. (pnas.org)
However, unlike other members of this family, lysosomal neuraminidase requires the carboxypeptidase protective protein/cathepsin A (PPCA) for intracellular transport and lysosomal activation. (acris-antibodies.com)
The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is an important multifunctional envelope protein, which plays key roles in virus attachment, neuraminidase and fusion promotion activities. (umd.edu)
A recent crystal structure of the HN protein of NDV gives valuable information about the location of amino acids involved in receptor-binding, neuraminidase and fusion promotion activities of the protein. (umd.edu)
α2-3,6,8,9 Neuraminidase A has activity over a broad pH range, and has been found to work well on a protein that has been denatured. (neb.com)
Tamiflu, co-developed with Gilead Sciences, Inc., is a systemic treatment for all common strains of influenza (Types A and B). The medication targets one of two major surface structures on the influenza virus, the neuraminidase protein. (gilead.com)
The neuraminidase protein is virtually the same in all common strains of influenza. (gilead.com)
The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) with its immunotherapeutic activities and sialic acid binding abilities is a promising cancer adjuvant. (jcancer.org)
Its heamaglutinin-neuraminidase (HN) protein is a multifunctional protein. (jcancer.org)
This protein consists of two domains associated with the hemagglutinin and neuraminidase activities which mediate the recognition as well as cleavage of the sialic acid containing receptors [ 5 ]. (jcancer.org)
A neuraminidase from Streptococcus pneumoniae has the features of a surface protein. (asm.org)
The predicted molecular weight of the protein and certain amino acid sequences are typical of other neuraminidases. (asm.org)
We have previously shown that TGF-β activity increases during influenza virus infection in mice and suggested that the neuraminidase (NA) protein mediates this activation. (prolekare.cz)

Neuraminidases, also called sialidases, catalyze the hydrolysis of terminal sialic acid residues from the newly formed virions and from the host cell receptors. (wikipedia.org)
There are two major classes of Neuraminidase that cleave exo or endo poly-sialic acids: Exo hydrolysis of α-(2→3)-, α-(2→6)-, α-(2→8)-glycosidic linkages of terminal sialic acid residues Endo hydrolysis of (2→8)-α-sialosyl linkages in oligo- or poly(sialic) acids Neuraminidases, also called sialidases, catalyze the hydrolysis of terminal sialic acid residues from the newly formed virions and from the host cell receptors. (wikipedia.org)
Sialic acid 3 is now more often called N-acetyl neuraminic acid , and hence the name of RDE was changed yet again, this time to neuraminidase. (everything2.com)
α2-3,6,8 Neuraminidase catalyzes the hydrolysis of α2-3, α2-6, and α2-8 linked sialic acid residues from glycoproteins and oligosaccharides. (neb.com)
These analogues have been developed from the structure of sialic acid, the neuraminidase (NA) substrate. (unboundmedicine.com)
Parainfluenza virus type 3 hemagglutinin-neuraminidase is expressed by HPIV paramyxoviruses that bind to sialic acid-containing receptor molecules on the surface of host lung cells. (functionalglycomics.org)
The current strategy for treating influenza focuses on inhibiting the function of neuraminidase, which is an enveloped enzyme located on the surface of both influenza A and B. Influenza neuraminidase is an exosialidase that recognizes the α -ketosidic linkage between neuraminic acid (or sialic acid) and carbohydrate residues ( Von Itzstein, 2011 ). (peerj.com)
Neuraminidases are enzymes that cleave sialic acid groups from glycoproteins. (creativebiomart.net)
Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. (creativebiomart.net)
The main function of influenza neuraminidase (NA) involves enzymatic cleavage of sialic acid from the surface of host cells resulting in the release of the newly produced virions from infected cells, as well as aiding the movement of virions through sialylated mucus present in the respiratory tract. (hku.hk)
Our objectives were then to investigate both sialic acid binding and cleavage of neuraminidase at an atomic resolution level. (hku.hk)

These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. (abcam.com)
At present, 18 hemagglutinin subtypes (H1-H18) and 11 neuraminidase subtypes (N1-N11) are recognized. (cdc.gov)
Influenza A viruses can be classified into subtypes based on the antigenic properties of their surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA). (pnas.org)
Based on mean IC 50 values, influenza A viruses (with neuraminidase subtypes N1 and N2) were more sensitive to both the NA inhibitors than were influenza B strains. (health.gov.au)

Compared to the positive controls, all tested polyphenols displayed a weak inhibition of the viral enzyme but similar or even higher potency on the bacterial neuraminidase. (rcsb.org)
Both the neuraminidase (NA) inhibition assay and CETSA demonstrated that isoimperatorin exerts an inhibitory effect on NA-mediated progeny virus release. (frontiersin.org)
May be used in immunoassays to detect and quantitate Influenza B neuraminidase and in neuraminidase inhibition assays. (lsbio.com)
Positive samples were inoculated in MDCK cells and virus phenotypic susceptibility to neuraminidase inhibitors (NAIs) was assessed using fluorescent NA inhibition. (who.int)
Reduced inhibition (RI) by one or more neuraminidase inhibitor was exhibited by 0.2% of viruses tested (n = 32). (openrepository.com)
Two hundred and forty-five human influenza A and B viruses isolated in Australia between 1996 and 2003 were tested for their sensitivity to the NA inhibitor drugs, zanamivir and oseltamivir using a fluorescence-based neuraminidase inhibition assay. (health.gov.au)

Here, we describe a mutation in IAV nucleoprotein (NP) that enhances replication and transmission in guinea pigs while selectively reducing neuraminidase (NA) gene segment packaging into virions. (pnas.org)
The sequence of the cloned neuraminidase gene (nan A), was compared to other bacterial neuraminidases to identify conserved residues, and also utilising crystallography data, predictions were made of the residues likely to be important in catalysis. (bl.uk)
Cloning and expression of the Bacteroides fragilis TAL2480 neuraminidase gene, nanH, in Escherichia coli. (asm.org)
We have cloned the Bacteroides fragilis TAL2480 neuraminidase (NANase) structural gene, nanH, in Escherichia coli. (asm.org)
Here, we assessed the ability of a novel dual-specific anti-tumor oncolytic adenovirus, expressing the hemagglutinin-neuraminidase (HN) gene from the Newcastle disease virus under the human telomerase reverse transcriptase (hTERT) promoter (Ad-hTERTp-E1a-HN), to inhibit esophageal cancer EC-109 cells in culture and to reduce tumor burden in xenografted BALB/c nude mice. (mdpi.com)
Cloning and characterization of nanB, a second Streptococcus pneumoniae neuraminidase gene, and purification of the NanB enzyme from recombinant Escherichia coli. (asm.org)
Streptococcus pneumoniae is believed to produce more than one form of neuraminidase, but there has been uncertainty as to whether this is due to posttranslational modification of a single gene product or the existence of more than one neuraminidase-encoding gene. (asm.org)
Only one stable pneumococcal neuraminidase gene (designated nanA) has been described. (asm.org)
In the present study, we isolated and characterized a second neuraminidase gene (designated nanB), which is located close to nanA on the pneumococcal chromosome (approximately 4.5kb downstream). (asm.org)
A gene from Streptococcus pneumoniae (nanA), with features entirely consistent with a neuraminidase gene, has been sequenced. (asm.org)
High levels of neuraminidase activity were obtained after cloning of this gene, without flanking sequences, into a high-expression vector. (asm.org)
The nanH structural gene for neuraminidase was cloned from B. fragilis TM4000 and was used to create two isogenic strains with chromosomal disruptions at the nanH gene. (asm.org)
In this study, we investigated the evolutionary trajectory of the main lineages of N1 type neuraminidase (NA) gene sequences of influenza A viruses by estimating their evolutionary rates and the selection pressures exerted upon them. (eurekamag.com)

When newly created viruses bud off (wrapped in an envelope of the host cell's own membrane), the neuraminidase is needed to cut the viruses' section of the cell membrane free from the host cell. (everything2.com)
If the neuraminidase is blocked, the newly created viruses cannot break away from the body of the host cell, and the infection stops. (everything2.com)
The neuraminidases of HiNi viruses also are similar to a neuraminidase in the current vaccine strain. (thefreedictionary.com)
A neuraminidase located on the surface of the virus plays an important role in viral reproduction by contributing to the release of viruses from infected host cells. (mdpi.com)
Neuraminidase Mutations Conferring Resistance to Oseltamivir in Influenza A(H7N9) Viruses. (sigmaaldrich.com)
Treatment of infected patients with the neuraminidase (NA) inhibitor oseltamivir was associated with emergence of viruses carrying NA substitutions. (sigmaaldrich.com)
The NA-Star® Influenza Neuraminidase Inhibitor Resistance Detection Kit includes everything you need to quantitate neuraminidase activity and neuraminidase inhibitor resistance in avian, equine, human (types A and B), and porcine influenza viruses. (thermofisher.com)
Oseltamivir and zanamivir are two neuraminidase inhibitors (NAIs) active on A and B influenza viruses. (unboundmedicine.com)
Neuraminidase is one of the two surface glycoproteins of influenza A and B viruses. (eur.nl)
To this aim, one of the most promising approaches consists to generate recombinant viruses harboring partially truncated neuraminidase (NA) segments. (omicsonline.org)
In this study, we described a paper-based neuraminidase assay sensor (PNAS) which can be applied to detect the infection by influenza viruses. (koreascience.or.kr)
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors and status of novel antivirals, 2016-2017. (openrepository.com)
A total of 13672 viruses, collected by World Health Organization recognised National Influenza Centres between May 2016 and May 2017, were assessed for neuraminidase inhibitor susceptibility by four WHO Collaborating Centres for Reference and Research on Influenza and one WHO Collaborating Centre for the Surveillance Epidemiology and Control of Influenza. (openrepository.com)
Analysis of 13581 neuraminidase sequences retrieved from public databases, of which 5243 sequences were from viruses not included in the phenotypic analyses, identified 58 further viruses (29 without phenotypic analyses) with amino acid substitutions associated with RI by at least one neuraminidase inhibitor. (openrepository.com)
Influenza neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the host cell. (creativebiomart.net)
A comparison of IC 50 values for viruses isolated before and after the release of the NA inhibitors in Australia, found there was no significant difference in the sensitivity of strains to either neuraminidase inhibitor and none of the isolates tested showed clinically significant resistance. (health.gov.au)
Viruses resistant to the neuraminidase inhibitors can be generated in vitro by multiple passage in the presence of the drugs, however many of these strains demonstrate a significantly reduced infectivity in animal models. (health.gov.au)
The emergence of viruses resistant to neuraminidase (NA) inhibitors and M2 ion channel inhibitors underlines the need for alternate anti-influenza drugs with novel mechanisms of action. (readbyqxmd.com)

Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins. (uniprot.org)
α2-3 Neuraminidase S is a highly specific exoglycosidase that catalyzes the hydrolysis of α2-3 linked N-acetyl-neuraminic acid residues from glycoproteins and oligosaccharides. (creative-enzymes.com)
Several reports describe the use of different expression systems to obtain recombinant immunogens based on hemagglutinin-neuraminidase (HN) or F glycoproteins of NDV with various degrees of success ( 2 , 9 , 10 , 17 , 24 ). (asm.org)
Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. (creativebiomart.net)

The Trypanosoma cruzi neuraminidase contains sequences similar to bacterial neuraminidases, YWTD repeats of the low density lipoprotein receptor, and type III modules of fibronectin. (rupress.org)
NanA contains the four copies of the sequence SXDXGXTW that is present in all the bacterial neuraminidases previously described. (asm.org)

Our results showed that recombinant influenza virus harboring truncated neuraminidase segment abrogated lung and systemic inflammatory response in wild type mice and were completely harmless to KO mice. (omicsonline.org)
The hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus (NDV) was obtained as a recombinant antigen in Rachiplusia nu larvae. (asm.org)
Recombinant H7N9(A/Anhui/1/2013) Neuraminidase (AGI60300.1) (His36-Leu465) was expressed , the cell lysates are collected, and bio-activity was tested. (creativebiomart.net)

Amantadine and rimantadine are approved for treating influenza A, while the neuraminidase inhibitor drugs zanamivir and oseltamivir are approved to treat both influenza A and B [6-8]. (thefreedictionary.com)
The influenza virus neuraminidase (NA) inhibitors zanamivir and oseltamivir were introduced into clinical practice in various parts of the world between 1999 and 2002. (asm.org)

Neuraminidase inhibitors (NAIs) are recommended for the control of severe influenza A and B infections (1). (thefreedictionary.com)
There are two major classes of antivirals available for the treatment and prevention of influenza, the M2 inhibitors and the neuraminidase inhibitors (NAIs). (nih.gov)
This study explores the chemical space of neuraminidase inhibitors (NAIs), which provides an opportunity to obtain further molecular insights regarding the underlying basis of their bioactivity. (peerj.com)
Furthermore, molecular docking was employed to investigate the binding modes and their moiety preferences of active NAIs against both influenza A and B neuraminidases. (peerj.com)
Moreover, novel NAIs with robust binding fitness towards influenza A and B neuraminidase were generated via combinatorial library enumeration and their binding fitness was on par or better than FDA-approved drugs. (peerj.com)

They have described how to use their newly discovered compounds to interrupt the enzyme neuraminidase 's facilitation of influenza's spread. (thefreedictionary.com)
It is the enzyme neuraminidase, projecting from the surface of influenza virus particles, which allows the virus to leave infected cells and spread in the body. (nih.gov)
Radix Isatidis (Woad) is a traditional Chinese herb which inhibits the viral enzyme neuraminidase in a fashion comparable to that of Tamiflu. (greenmedinfo.com)

We developed a highly multiplexed padlock-ligation assay targeting signature sequences in the hemagglutinin and neuraminidase genes. (diva-portal.org)

Escape mutants, selected by growing virus in the presence of monoclonal antibodies to the neuraminidase, possess single amino acid sequence changes. (nih.gov)
The only universally conserved sequence amongst all influenza A viral neuraminidase (NA) is located between amino acids 222-230 and plays crucial roles in viral replication. (nih.gov)

The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. (proteopedia.org)
Neuraminidase inhibitor sensitivity and receptor-binding specificity of Cambodian clade 1 highly pathogenic H5N1 influenza virus. (semanticscholar.org)

We here assess the inhibitory potency of plant tannins versus clinically used inhibitors on both a viral and a bacterial model neuraminidase by applying the 2'-(4-methylumbelliferyl)-α-d- N -acetylneuraminic acid (MUNANA)-based activity assay. (rcsb.org)
In this paper, the in vitro inhibitory action of Radix Isatidis on neuraminidase (NA) was investigated by fluorometric assay with 4-methylumbelliferyl-D-N-acetylneuraminate (FL-MU-NANA) method. (greenmedinfo.com)
The NA-Star® Influenza Neuraminidase Inhibitor Reagent kit provides all necessary assay reagents enabling improved global assay standardization and more accurate comparison of results lab-to-lab. (thermofisher.com)
The NA-Star® Influenza Neuraminidase Inhibitor Resistance Detection Kit includes NA-Star chemiluminescent substrate for neuraminidase, all necessary assay reagents, and microplates -- everything you need for the fast, accurate quantitation of neuraminidase inhibitor resistance in influenza virus isolates. (thermofisher.com)
This assay utilizes Amplex® Red reagent to detect hydrogen peroxide generated by galactose oxidase oxidation of desialiated galactose, the end result of neuraminidase action. (thermofisher.com)
The purified neuraminidases were assayed for enzyme activity using a colorimetric assay. (bl.uk)
A subtyping assay for both the hemagglutinin (HA) and neuraminidase (NA) surface antigens of the avian influenza virus (AIV) has been developed. (diva-portal.org)

Dynamic range of four orders of magnitude enables you to quantitate virus isolates over a broad range of virus concentration and with varying levels of neuraminidase activity without performing numerous sample dilutions. (thermofisher.com)

Parainfluenza virus type 3 hemagglutinin-neuraminidase binds sialylated glycans. (functionalglycomics.org)
Parainfluenza virus type 3 hemagglutinin-neuraminidase is expressed by paramyxoviruses. (functionalglycomics.org)

Clinical efficacy and safety of the selective oral neuraminidase inhibitor oseltamivir in treating acute influenza--placebo-controlled double-blind multicenter phase III trial]. (semanticscholar.org)
We conducted the placebo-controlled double-blind multicenter Phase III trial of newly developed selective oral neuraminidase inhibitor, oseltamivir phosphate (Ro64-0796), in order to evaluate the efficacy and safety, when Ro64-0796 was administered orally to both type A and type B influenzavirus infected patients. (semanticscholar.org)

Antibodies which inhibit the enzyme limit the infection, but antigenic variation of the neuraminidase renders it ineffective in a vaccine. (nih.gov)
We have studied the maturation of the influenza A virus neuraminidase (NA), using monoclonal antibodies (MAbs) with different conformational specificities against the head domains of the N8 NA. (asm.org)
The wide range of reactivity probably relates to the infection history of the donor, whose plasmablasts generated antibodies with long regions that insert into the active site of the neuraminidase enzyme. (flutrackers.com)
We describe three human monoclonal antibodies isolated from an H3N2-infected donor that bind with exceptional breadth to multiple different influenza A and B virus neuraminidases. (flutrackers.com)
These antibodies neutralize the virus, mediate effector functions, are broadly protective in vivo, and inhibit neuraminidase activity by directly binding to the active site. (flutrackers.com)
Structural and functional characterization of these antibodies will inform the development of neuraminidase-based universal vaccines against influenza virus. (flutrackers.com)

The following is a list of major classes of neuraminidase enzymes: Viral neuraminidase Bacterial neuraminidase Mammalian neuraminidases: Influenza neuraminidase is a mushroom-shaped projection on the surface of the influenza virus. (wikipedia.org)
Mammalian neuraminidases have been localised inside the lysosomes, in the cytosol as well as in the various membranes of the cell cytocavitary system (1). (springer.com)

Two fold dilutions of α2-3,6,8 Neuraminidase are incubated with 1 nmol AMC-labeled substrate and 1X GlycoBuffer 1 in a 10 µl reaction. (neb.com)
The three-dimensional structure of the haemagglutinin-neuraminidase (HN) from a human parainfluenza virus is described at ca 2.0 A resolution, both in native form and in complex with three substrate analogues. (nih.gov)
Simply incubate your virus samples with dilutions of neuraminidase inhibitor, add NA-Star chemiluminescent substrate, incubate again, and then add the accelerator solution, which triggers light emission from the reaction product. (thermofisher.com)
S. Herlambang and R. Saleh, "The Comparison of Substrate Stability in Neuraminidase Type 2 (N2) Active Site between A/Tokyo/3/67 and A/Pennsylvania/10218/84 with Heating Dynamics Simulation," World Journal of Condensed Matter Physics , Vol. 1 No. 3, 2011, pp. 77-87. (scirp.org)
The PNAS was designed and manufactured to quantitatively identify the levels of neuraminidase in the sample, which is based on colorimetric analysis using the X-Neu5Ac substrate. (koreascience.or.kr)

Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance. (nih.gov)
In order to create more potent neuraminidase inhibitors and fight against the surge in resistance resulting from naturally-occurring mutations, these anti-influenza drugs have been used as templates for the development of new neuraminidase inhibitors through structure-activity relationship studies. (mdpi.com)
The NA-Star® Influenza Neuraminidase Inhibitor Resistance Detection Kit is designed for the rapid and sensitive quantitation of influenza neuraminidase inhibitor resistance in dilutions of virus culture medium in a 96-well microplate format. (thermofisher.com)
The kit's fast and easy protocol and convenient 96-well plate format make it ideal for monitoring influenza virus neuraminidase inhibitor resistance, as well as high-throughput inhibitor compound screening. (thermofisher.com)
The kit's chemiluminescent-based detection technology provides a wide dynamic range -- greater than four orders of magnitude of neuraminidase concentration (two orders of magnitude greater than fluorescent MUNANA-based assays) -- enabling you to quantitate neuraminidase inhibitor resistance levels over a broad range of virus concentration and neuraminidase activity without having to test multiple virus dilutions. (thermofisher.com)
In order to monitor the potential development of resistance, the Neuraminidase Inhibitor Susceptibility Network was established to coordinate testing of clinical isolates collected through the World Health Organization influenza surveillance network from different regions of the world (M. Zambon and F. G. Hayden, Antivir. (asm.org)
However, H257Y mutation responsible for resistance to neuraminidase inhibitors was missing. (physiciansweekly.com)

Trypanosoma cruzi expresses a developmentally regulated neuraminidase (TCNA) implicated in parasite invasion of cells. (rupress.org)

The neuraminidase inhibitors zanamivir, laninamivir, oseltamivir and peramivir have been commercialized and have been demonstrated to be potent influenza viral neuraminidase inhibitors against most influenza strains. (mdpi.com)
The fight against the emergence of mutant influenza strains has led to the screening of an increasing number of compounds for inhibitory activity against influenza neuraminidase. (peerj.com)

Neuraminidase enzymes are glycoside hydrolase enzymes that cleave the glycosidic linkages of neuraminic acids . (wikipedia.org)
Its neuraminidase domain has the CAZy designation glycoside hydrolase family 83 (GH83). (wikipedia.org)

Neuraminidase (NA) is an important antiviral drug target. (flutrackers.com)

Like influenza, the paramyxoviruses show hemagglutinin and neuraminidase (HN) activities, but in this case, the two activities reside on the same glycoprotein. (functionalglycomics.org)
turned their attention away from the current vaccine target-the mutable hemagglutinin-and investigated an alternative, less variable virus-coat glycoprotein: neuraminidase. (flutrackers.com)

Swiss-Prot lists 137 types of neuraminidase from various species as of October 18, 2006. (wikipedia.org)
Three types of neuraminidase are found in mammals and are defined as lysosomal, plasma membrane and cytosolic on the basis of their biochemical properties and subcellular distribution. (acris-antibodies.com)

This 2016/17 analysis demonstrates that neuraminidase inhibitors remain suitable for treatment and prophylaxis of influenza virus infections, but continued monitoring is important. (openrepository.com)

Reagents for analysis of neuraminidase-based immunity are scarce, and assays are not widely used for clinical studies evaluating vaccines. (eur.nl)
The underlying anti-influenza virus mechanism of SJS was studied by a series of biological assays to determine if hemagglutinin, ribonucleoprotein complex or neuraminidase were targets of SJS. (biomedcentral.com)

BACKGROUND: Neuraminidase inhibitors (NI) are recommended for use against influenza and its complications in inter-pandemic years and during pandemics. (greenmedinfo.com)
Neuraminidase plays a crucial role in the release of new virions from the infected cell 1 and the structure of the enzyme active site is highly conserved across the known types of influenza A and B which are responsible for epidemic and, for influenza A, pandemic human disease. (health.gov.au)

The viral neuraminidases are frequently used as antigenic determinants found on the surface of the influenza virus. (wikipedia.org)

The best-known neuraminidase is the viral neuraminidase , a drug target for the prevention of the spread of influenza infection. (wikipedia.org)
Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium. (proteopedia.org)
Similar reactions may occur after paramyxovirus infection due to the action of viral neuraminidase. (jimmunol.org)

The protective effects of the mutated neuraminidases in mice was investigated by immunization followed by challenge with virulent Streptococcus penumoniae. (bl.uk)

There have been many resource requests for glycan array screening of paramyxovirus hemagglutinin-neuraminidase (for example, click here ). (functionalglycomics.org)

Hemagglutinin-neuraminidase can be found in a variety of paramyxoviruses including mumps virus, human parainfluenza virus 3, and the avian pathogen Newcastle disease virus. (wikipedia.org)
Types include: Mumps hemagglutinin-neuraminidase Parainfluenza hemagglutinin-neuraminidase Hemagglutinin-neuraminidase inhibitors have been investigated and suggest that there may applications for human use in the future. (wikipedia.org)
To see all glycan array results for parainfluenza hemagglutinin-neuraminidase, click here . (functionalglycomics.org)

While there are data that show a protective role of anti-neuraminidase immunity, many questions remain unanswered. (eur.nl)

The specific neuraminidase activity of infective trypomastigotes obtained from tissue culture and from the bloodstream of infected mice is 7 to 15 times higher than that of the acellular culture forms. (sciencemag.org)
This study did not evaluate specific neuraminidase inhibitors. (lasvegasemr.com)

Neuraminidases or sialidases are exoglycosidases that catalyze the cleavage of a glycosidically linked terminal N acetyl neuraminic acid from sialylated glycoconjugates. (acris-antibodies.com)

Chemical structures of the neuraminidase inhibitors (A) DANA, (B) zanamivir, (C) oseltamivir carboxylate, (D) peramivir, and (E) laninamivir. (nih.gov)
Both HA-mediated entry and viral superinfection were rescued by the neuraminidase inhibitors oseltamivir carboxylate and zanamivir. (asm.org)

Laborda P, Wang S-Y, Voglmeir J. Influenza Neuraminidase Inhibitors: Synthetic Approaches, Derivatives and Biological Activity. (mdpi.com)

Anatomy5

Organisms23

Diseases4

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes9

Information Science2

Health Care1

The effects of digestive enzymes on characteristics of placental insulin receptor. Comparison of particulate and soluble receptor preparations. (1/3160)

Cell surface sialic acid and the regulation of immune cell interactions: the neuraminidase effect reconsidered. (2/3160)

N-Linked glycosylation and sialylation of the acid-labile subunit. Role in complex formation with insulin-like growth factor (IGF)-binding protein-3 and the IGFs. (3/3160)

Binding partners for the myelin-associated glycoprotein of N2A neuroblastoma cells. (4/3160)

Carbohydrate on human factor VIII/von Willebrand factor. Impairment of function by removal of specific galactose residues. (5/3160)

Tandem amino acid repeats from Trypanosoma cruzi shed antigens increase the half-life of proteins in blood. (6/3160)

Amino acid substitutions in a conserved region in the stalk of the Newcastle disease virus HN glycoprotein spike impair its neuraminidase activity in the globular domain. (7/3160)

Ortho- and paramyxoviruses from migrating feral ducks: characterization of a new group of influenza A viruses. (8/3160)

Neuraminidase

Zanamivir

Sialic Acids

Oseltamivir

Influenza A virus

Pyrans

Neuraminic Acids

Orthomyxoviridae

N-Acetylneuraminic Acid

Hemagglutinin Glycoproteins, Influenza Virus

Influenza, Human

Hemagglutination, Viral

Guanidines

Antiviral Agents

Influenza A Virus, H1N1 Subtype

Hemagglutinins, Viral

Orthomyxoviridae Infections

Influenza B virus

Influenza A Virus, H3N2 Subtype

Influenza A Virus, H5N1 Subtype

Influenza in Birds

Drug Resistance, Viral

Galactose Oxidase

Ferrets

Hemagglutination Inhibition Tests

Hemagglutinins

HN Protein

Reassortant Viruses

Lectins

Acetamides

Influenza A Virus, H2N2 Subtype

Influenza A Virus, H7N9 Subtype

Influenza A Virus, H9N2 Subtype

Dogs

Newcastle disease virus

Influenza Vaccines

Clostridium perfringens

Viral Proteins

Cell Line

Glycoproteins

Wheat Germ Agglutinins

Parainfluenza Virus 3, Human

Madin Darby Canine Kidney Cells

Carbohydrates

Hemadsorption

Peanut Agglutinin

Ducks

Birds

Cathepsin A

Receptors, Virus

Gangliosides

Viral Plaque Assay

Cyclopentanes

Glycosylation

Hemagglutination Tests

Paramyxoviridae

Molecular Sequence Data

Hymecromone

Erythrocytes

Periodic Acid

Glycoside Hydrolases

Enzyme Inhibitors

Mucolipidoses

Molecular Weight

Hemagglutination

Antibodies, Viral

Arthrobacter

Pandemics

Amantadine

Chick Embryo

Virus Replication

Sialoglycoproteins

Pronase

Electrophoresis, Polyacrylamide Gel

Trypsin

Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase

Actinomycetaceae

Cell Membrane

Chickens

Parainfluenza Virus 1, Human