Cells with the capacity to take up and decarboxylate the amine precursors DIHYDROXYPHENYLALANINE or 5-HYDROXYTRYPTOPHAN. This is a property of endocrine cells of neural and non-neural origin. APUDOMA is a general term collectively applied to tumors associated with APUD cells.
Small clusters of chemoreceptive and supporting cells located near the ARCH OF THE AORTA; the PULMONARY ARTERIES; and the CORONARY ARTERIES. The aortic bodies sense PH; CARBON DIOXIDE; and OXYGEN concentrations in the BLOOD and participate in the control of RESPIRATION. The aortic bodies should not be confused with the PARA-AORTIC BODIES in the abdomen (which are sometimes also called aortic bodies).
A blue-red, extremely painful vascular neoplasm involving a glomeriform arteriovenous anastomosis (glomus body), which may be found anywhere in the skin, most often in the distal portion of the fingers and toes, especially beneath the nail. It is composed of specialized pericytes (sometimes termed glomus cells), usually in single encapsulated nodular masses which may be several millimeters in diameter (From Stedman, 27th ed). CHEMODECTOMA, a tumor of NEURAL CREST origin, is also sometimes called a glomus tumor.
A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.
Several clusters of chemoreceptive and supporting cells associated with blood vessels and nerves (especially the glossopharyngeal and vagus). The nonchromaffin paraganglia sense pH, carbon dioxide, and oxygen concentrations in the blood and participate in respiratory, and perhaps circulatory, control. They include the CAROTID BODY; AORTIC BODIES; the GLOMUS JUGULARE; and the GLOMUS TYMPANICUM.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The lower portion of the BRAIN STEM. It is inferior to the PONS and anterior to the CEREBELLUM. Medulla oblongata serves as a relay station between the brain and the spinal cord, and contains centers for regulating respiratory, vasomotor, cardiac, and reflex activities.
Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.
Separation of particles according to density by employing a gradient of varying densities. At equilibrium each particle settles in the gradient at a point equal to its density. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Exclusive legal rights or privileges applied to inventions, plants, etc.
Liquid components of living organisms.
Process of using a rotating machine to generate centrifugal force to separate substances of different densities, remove moisture, or simulate gravitational effects. It employs a large motor-driven apparatus with a long arm, at the end of which human and animal subjects, biological specimens, or equipment can be revolved and rotated at various speeds to study gravitational effects. (From Websters, 10th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.
Techniques to partition various components of the cell into SUBCELLULAR FRACTIONS.
Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.
Cell surface receptors that bind peptide messengers with high affinity and regulate intracellular signals which influence the behavior of cells.
Lutetium. An element of the rare earth family of metals. It has the atomic symbol Lu, atomic number 71, and atomic weight 175.
Cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behavior of cells. Somatostatin is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Activated somatostatin receptors on pituitary cells inhibit the release of growth hormone; those on endocrine and gastrointestinal cells regulate the absorption and utilization of nutrients; and those on neurons mediate somatostatin's role as a neurotransmitter.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A general term collectively applied to tumors associated with the APUD CELLS series, irrespective of their specific identification.
Affection; in psychiatry commonly refers to pleasure, particularly as it applies to gratifying experiences between individuals.
In pathology, an apudoma is an endocrine tumour that arises from an APUD cell from structures such as the ampulla of Vater. ... They were historically thought to be derived from neural crest cells, but this has since been shown to be untrue (see ... 2000). "Superficial undifferentiated small cell carcinoma of the esophagus showing an interesting growing pattern in histology ...
Glomus type II cells are not innervated. Glomus type I cells are embryonically derived from the neural crest. In the carotid ... APUD) cells in the avian carotid body, using a cytochemical marker system". Histochemie. 34 (3): 191-203. doi:10.1007/ ... Glomus cells are the cell type mainly located in the carotid bodies and aortic bodies. Glomus type I cells are peripheral ... Glomus type II cells are sustentacular cells having a similar supportive function to glial cells. The signalling within the ...
Merkel cells are sometimes considered APUD cells (an older definition. More commonly classified as a part of dispersed ... Though it has been reported that Merkel cells are derived from neural crest cells, more recent experiments in mammals have ... Merkel cells, also known as Merkel-Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for ... Merkel cells are found in the skin and some parts of the mucosa of all vertebrates. In mammalian skin, they are clear cells ...
APUD cells are considered part of the neuroendocrine system, and share many staining properties with neuroendocrine cells. ... Neuroendocrine tumor Neuroendocrinology Neurohormone Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 10: Neural and ... Neuroendocrine cells are cells that receive neuronal input (neurotransmitters released by nerve cells or neurosecretory cells) ... Pulmonary neuroendocrine cells are also known as Kulchitsky cells or K cells. They are located in the respiratory epithelium of ...
EC cells have been found in biopsies of developing GIT tissue before the migration of neural crest cells. Whilst EC cells have ... "Enterochromaffin-like Cells"[edit]. "Enterochromaffin-like (ECL) cells" are a population of cells that are found in the gastric ... 1985). "Ultrastructure of enterochromaffin cells and associated neural and vascular elements in the mouse duodenum". Cell and ... EC cells are small polygonal cells located in the crypts between intestinal villi. They are discriminated from other cells of ...
The fungus was used to treat many inflammatory, stomach, and neural diseases. Southern China's Miao people continue to use it ... Wang H, Ng TB (2003). "A novel ribonuclease from the veiled lady mushroom Dictyophora indusiata". Biochemistry and Cell Biology ... 1801). Synopsis Methodica Fungorum [Synopsis of a Methodology of Mushrooms] (in Latin). Göttingen, Germany: Apud H. Dieterich. ... eudesmane derivatives isolated from fungi and were found to promote the synthesis of nerve growth factor in astroglial cells. ...
"Excitation-neurogenesis coupling in adult neural stem/progenitor cells". Neuron. 42 (4): 535-52. doi:10.1016/S0896-6273(04) ... Apud JA, Mattay V, Chen J, Kolachana BS, Callicott JH, Rasetti R, Alce G, Iudicello JE, Akbar N, Egan MF, Goldberg TE, ... "Excitation-neurogenesis coupling in adult neural stem/progenitor cells". Neuron. 42 (4): 535-52. doi:10.1016/S0896-6273(04) ... Neural networks help us understand how the brain sends and receives different messages to the body, and how they are connected ...
"Psychedelics Promote Structural and Functional Neural Plasticity". Cell Reports. 23 (11): 3170-3182. doi:10.1016/j.celrep. ... Ismael Eduardo Apud Peláez. (2020). Ayahuasca: Between Cognition and Culture. Publicacions Universitat Rovira i Virgili. ISBN ... "Psychedelics Promote Structural and Functional Neural Plasticity". Proc Natl Acad Sci U S A. 106 (46): 19575-19580. doi:10.1073 ...
It has been a matter of debate whether in neural cells of the CNS the enzymatic domain of MB-COMT is oriented toward the ... Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM, Herman MM, Apud J, Egan MF, Kleinman JE, ... Juarez B, Han MH (September 2016). "Diversity of Dopaminergic Neural Circuits in Response to Drug Exposure". ... Journal of Neural Transmission. Supplementum. 32: 3-18. doi:10.1007/978-3-7091-9113-2_1. ISBN 978-3-211-82239-5. PMID 2089098. ...
The pars distalis contains two types of cells, including chromophobe cells and chromophil cells. The chromophils can be further ... Racagni, G; Apud, J.A; Cocchi, D; Locatelli, V; Muller, E.E. (1982) GABAergic control of anterior pituitary hormone secretion. ... In all animals, the fleshy, glandular anterior pituitary is distinct from the neural composition of the posterior pituitary. ... divided into acidophils (alpha cells) and basophils (beta cells). These cells all together produce hormones of the anterior ...
1- Donor cell produces pilus. 2- Pilus attaches to recipient cell, bringing the two cells together. 3- The mobile plasmid is ... Neural and biochemical control mechanisms. Different phases of digestion take place including: the cephalic phase, gastric ... 4- Both cells recircularize their plasmids, synthesize second strands, and reproduce pili; both cells are now viable donors. ... This triggers G cells to release gastrin, which in turn stimulates parietal cells to secrete gastric acid. Gastric acid is ...
Though it has been reported that Merkel cells are derived from neural crest cells,[4] more recent experiments in mammals have ... Merkel cells are sometimes considered APUD cells (an older definition. More commonly classified as a part of dispersed ... Merkel cells, also known as Merkel-Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for ... Merkel cells are found in the skin and some parts of the mucosa of all vertebrates. In mammalian skin, they are clear cells ...
The APUD system cells are of 3 types:. 1. Neural Crest Origin: Thyroid, Adrenal Medulla, Melanoblasts of the Dermis, Cells in ... Some of these adaptations are cell hypertrophy, cell atrophy or cell injury which may be reversible or can result in final ... The cell division produces various cells for the development of different organs but all these cells arise initially from only ... Some APUD cells of disputed origin are Islets of Langerhans in the Pancreas.. Affection of these tissues, is due to longterm ...
Glomus type II cells are not innervated. Glomus type I cells are embryonically derived from the neural crest. In the carotid ... APUD) cells in the avian carotid body, using a cytochemical marker system". Histochemie. 34 (3): 191-203. doi:10.1007/ ... Glomus cells are the cell type mainly located in the carotid bodies and aortic bodies. Glomus type I cells are peripheral ... Glomus type II cells are sustentacular cells having a similar supportive function to glial cells. The signalling within the ...
"The APUD concept led to the belief that these cells arise from the embryologic neural crest. This hypothesis eventually was ... Small cell carcinoma · Verrucous carcinoma · Squamous cell carcinoma · Basal cell carcinoma · Transitional cell carcinoma · ... Similarly, overexpressing GEP-NET cells (neoplastic cells only) are avid for somatostatin analogs, and nearby cells are killed ... and nearby cells. Not all cells are immediately killed this way. The process of tumor cells dying as result of this therapy can ...
In pathology, an apudoma is an endocrine tumour that arises from an APUD cell from structures such as the ampulla of Vater. ... They were historically thought to be derived from neural crest cells, but this has since been shown to be untrue (see ... 2000). "Superficial undifferentiated small cell carcinoma of the esophagus showing an interesting growing pattern in histology ...
... cells of the gastroenteropancreatic endocrine system and in adrenal or extra-adrenal neurogenic sites. ... They originate in amine precursor uptake and decarboxylation (APUD) ... Neural crest cells are precursors of APUDoma and neurogenic cells.. The symptoms of VIPoma were initially described in 1958, ... 1, 2, 3] They originate in amine precursor uptake and decarboxylation (APUD) cells of the gastroenteropancreatic endocrine ...
Serotonergic branchial neuroepithelial cells (NECs) are putative O2 chemoreceptors believed to be homologous to the neural ... We therefore hypothesized that NECs contain ACh among other neurochemicals in cells belonging to the APUD series. Although ... Zinc Oxide Nanoparticles for Nonlinear Bioimaging, Cell Detection and Selective Cell Destruction Description: Light matter ... Finally, the results of this investigation suggest that the cells that respond to trypsin are surface cells, which have an ...
An approach for analyzing migration and eventual fate of avian neural crest cells in quail-chick chimeric embryos is described ... The problem of the neurectodermal origin of the cells of the APUD series. J. Embryol. Exp. Morphol. 41, 209-222 (1977). ... Maro, G. S. Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS. Nat. Neurosci. 7, (9), ... Dual Labeling of Neural Crest Cells and Blood Vessels Within Chicken Embryos Using ChickGFP Neural Tube Grafting and ...
Pluripotential hormone-secreting cells belonging to the APUD cell system (see p. 132) are distributed throughout the human ... foregut and its endocrine derivatives [75]. Pancreatic islet cell tumors... ... Pearse AGE, Polak J: Neural crest origin of the endocrine polypeptide (APUD) cells of the gastrointestinal tract and pancreas ... Pluripotential hormone-secreting cells belonging to the APUD cell system (see p. 132) are distributed throughout the human ...
APUD cells were once believed to originate from the embryologic neural crest, but current evidence suggests that these cells- ... The cells in pancreatic endocrine neoplasms are termed amine precursor uptake and decarboxylation (APUD) cells because they ... 15] Instead, the tumors arise from APUD stem cells, which are pluripotential neuroendocrine cells located within the ductular ... The origin of gut and pancreatic neuroendocrine (APUD) cells--the last word?. J Pathol. 1998 Oct. 186(2):117-8. [Medline]. ...
APUD cells, serotonin signaling. Neuroendocrine, amine precursor uptake decarboxylase (APUD) cells signaling, serotonin are ... Accumulating data now indicates that the gut microbiota also communicates with the CNS-possibly through neural, endocrine, and ... Reconstitution with CD4 T cells promoted accumulation of degranulated IL-4-expressing cells but only if T cells were stimulated ... TH2 cells elaborate cytokines, such as IL-4, IL-5, IL-9, and IL-13, which work with toxic mediators of innate immune cells to ...
What is neurosecretory cell? Meaning of neurosecretory cell medical term. What does neurosecretory cell mean? ... Looking for online definition of neurosecretory cell in the Medical Dictionary? neurosecretory cell explanation free. ... and the neurenteric and APUD cells. In the glial lineage, neural crest cells give rise to Schwann cells and other peripheral ... See also betz cells, gauchers cells, golgis cells, hela cells, hürthle cell, kupffers cells, merkel cell, mesangial cell, ...
... segmented cell explanation free. What is segmented cell? Meaning of segmented cell medical term. What does segmented cell mean? ... Looking for online definition of segmented cell in the Medical Dictionary? ... and the neurenteric and APUD cells. In the glial lineage, neural crest cells give rise to Schwann cells and other peripheral ... Kulchitsky cell. An APUD cell found in the lung.. Kupffer cell. See: Kupffer cell. L cell. An enteroendocrine cell that ...
APUD Cells [M0001632]. Cells with the capacity to take up and decarboxylate the amine precursors DIHYDROXYPHENYLALANINE or 5- ... a property of endocrine cells of neural and non-neural origin. APUDOMA is a general term collectively applied to tumors ... Embryonal Carcinoma Cells [M0022152]. * Embryonic Stem Cells [M0494884]. Cells derived from the BLASTOCYST INNER CELL MASS ... Alpha cells secrete GLUCAGON. * Goblet Cells [M0030041]. A glandular epithelial cell or a unicellular gland. Goblet cells ...
Index: LILACS (Americas) Main subject: APUD Cells / Uvea / Iris / Melanosis / Neural Crest / Nevus, Pigmented Language: Spanish ... Index: LILACS (Americas) Main subject: APUD Cells / Uvea / Iris / Melanosis / Neural Crest / Nevus, Pigmented Language: Spanish ... APUD Cells , Iris/pathology , Melanosis , Neural Crest/pathology , Nevus, Pigmented , Uvea/pathology , Choroid/pathology , ... El sistema APUD en la oftalmología III: tumores de la cresta neural. Derivados del sistema pigmentario (melanogénico). Nevi, ...
cell answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, Android, and ... and the neurenteric and APUD cells. In the glial lineage, neural crest cells give rise to Schwann cells and other peripheral ... blood cell. Any cell normally found circulating in the bloodstream. Blood cells include red cells and white cells. Red cells ... null cell. 1. A large lymphocyte without the cell markers of either a T cell or a B cell. Natural killer cells are examples of ...
... dispersed tissue specimens and cultured cells. In particular, the present inve ... The present invention relates to methods of enriching for desired cell population from cell sources, such as body fluids, ... APUD), islets of langerhans (alpha, beta, and delta), hepatocytes, and kupfer cells; cells of the skin, e.g. keratinocytes, ... cells of the neural system, e.g. astrocytes (protoplasmic and fibrous), microglia, oligodendrocytes, and neurons; cells of the ...
"The APUD concept led to the belief that these cells arise from the embryologic neural crest. This hypothesis eventually was ... NEC (G3), large cell or small cell type NEC (G3), large cell or small cell type (poorly differentiated NEN) ... Small cell carcinoma - Verrucous carcinoma - Squamous cell carcinoma - Basal cell carcinoma - Transitional cell carcinoma - ... Some of these malignant cells do not form a gland and are consistent in organ as different cells. (Like G cells in stomach.) ...
Neuroendocrine neoplasms of the larynx arise from APUD (amine precursor uptake and decarboxylase) cells. Neuroendocrine ... neoplasms of the larynx canbe divided into those of epithelial or neural origin. The latter consists of paragangliomas while ... which consist of the oat cell type, the intermediate cell type and the combined cell type. There are now over 500 cases of ... the group of the epithelial origin can be further divided into typical and atypical carcinoids, and small cell neuroendocrine ...
APUD, meaning amine precursor uptake and decarboxylation) properties. These cells, which are derived from neural crest cells, ... An apudoma is any endocrine tumor that arises from an APUD cell ( ... As such, symptoms and histology of pancreatic islet cell tumors ... Amine precursor uptake and decarboxylation cells are known to give rise to islet cell tumors of the pancreas, medullary ...
The ultrastructural features of tumors of cells of known neural crest origin, including a medullary carcinoma of the thyroid, ... It was shown that the small cells have morphologic characteristics of APUD cells. Also presented are the histologic features of ... and two cutaneous melanomas were compared with those of other APUD cell tumors including small cell carcinomas of...Continue ... Carcinoma, Squamous Cell. Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has ...
Primary renal neuroendocrine tumors are among the most unusual of all renal neoplasms, since neuroendocrine cells are not found ... Neuroendocrine tumors are a heterogeneous group of neoplasms that arise from neuroendocrine cells. ... Neuroendocrine tumors are thought to arise from neuroendocrine cells (NECs) or APUD cells. NECs have been described in the ... including entrapped neural crest cells in the metanephros during embryogenesis [6], neuroendocrine differentiation of a ...
... smooth muscle cells, and bone cells. * Endocrine Cells 0 questions * Cellules Apud 0 questions Cells with the capacity to take ... a property of endocrine cells of neural and non-neural origin. APUDOMA is a general term collectively applied to tumors ... The large luteal cells derive from the GRANULOSA CELLS. The small luteal cells derive from the THECA CELLS. ... They are similar in appearance to Langhans giant cells (GIANT CELLS, LANGHANS), but foreign-body giant cells have more abundant ...
... cells (DINES). They are also called APUD cells or ______ precursor _____ ___ cells, although not all enteroendocrine cells take ... cells are pyramidal shaped cells found in the upper half of gastric glands that stain red-pink with H and E ... regenerative cells are located primarily in the ____ and ____ of gastric glands and replace all other cells in the gland, pit, ... Mucous neck cells secrete a solubule mucous upon _____ stimulation that is not as thick as mucous produced by _____ ____ cells ...
To explain these common features, it has been hypothesized that pancreatic cells most likely co-opted a pre-existing gene ... To explain these common features, it has been hypothesized that pancreatic cells most likely co-opted a pre-existing gene ... Neurons and pancreatic endocrine cells have a common physiology and express a similar toolkit of transcription factors during ... Neurons and pancreatic endocrine cells have a common physiology and express a similar toolkit of transcription factors during ...
... corneal cells, plus some endocrine cells from the APUD program [4]. There are many domains within NC, among that your cells ... Neural stem cells can be found during neuronal advancement but are located in adult brains in stem cells niches also, causeing ... Upon TLR9-mediated CLL cell activation in typical cell culture moderate filled with 1 mM arginine, CLL cells got into the cell ... Since 1997, neural crest-derived multipotent stem cells (NCSCs) have already been determined and isolated from several cells ...
Frozen sections; Buffers; Quantitative Histochemistry; Concept of APUD and Clinical Cytochemistry; Electromicrography; Cell ... This would involve the study of the gross anatomy of the central nervous system including the brain, spinal cord and neural ... Proper use of the light microscope to recognize cells, tissues and organs. Interpretation of basic cellular structure as seen ... Histology of the Central Nervous System including brain, spinal cord and the neural pathways. ...
... islet cell tumours) are rare and usually sporadic, but they may be associated with complex familial endocrine cancer syndromes ... cells. APUD cells were initially believed to arise from the embryological neural crest. However, this theory has been disproved ... omnipotent stem cells. Since these enteroendocrine cells share many of the properties exhibited by neural cells, this has led ... These cells also share certain histological features with neural cells, including the presence of chromogranin-A, synaptophysin ...
Summary Studies on the developing mouse pancreas indicate that neuroectodermal cells from the neural crest, identifiable by ... their APUD-FIF characteristics, colonize the foregut at around the 10th day. Carried into the pancreatic anlagen, their ... The cell blot assay in analysis of rat anterior pituitary cell secretion (1994). ... The cell blot assay in analysis of rat anterior pituitary cell secretion (1994). ...
... are tumors that develop from the cells of the diffuse neuroendocrine system, such as the enterochromaffin (EC) cells. ... Neuroendocrine tumors are also known as apudomas, or tumors that contain apud cells. These cells release excessive amounts of a ... Group II (neural). Group II neuroendocrine tumors include paragangliomas, neuroblastomas, primitive neuroectodermal tumors, ... Specialized cell of the nervous system, that transmits nervous system signals. It consists of a cell body linked to a long ...
J. A. Apud, V. Mattay, J. Chen et al., "Tolcapone improves cognition and cortical information processing in normal human ... J. M. Maler, W. Seifert, G. Hüther et al., "Homocysteine induces cell death of rat astrocytes in vitro," Neuroscience Letters, ... Journal of Neural Transmission, vol. 112, no. 9, pp. 1213-1221, 2005. View at Publisher · View at Google Scholar · View at ... Journal of Neural Transmission, vol. 109, no. 2, pp. 175-179, 2002. View at Publisher · View at Google Scholar ...
  • The cells in pancreatic endocrine neoplasms are termed amine precursor uptake and decarboxylation (APUD) cells because they have a high amine content, are capable of amine precursor uptake, and contain an amino acid decarboxylase. (medscape.com)
  • Cells with the capacity to take up and decarboxylate the amine precursors DIHYDROXYPHENYLALANINE or 5-HYDROXYTRYPTOPHAN - a property of endocrine cells of neural and non-neural origin. (slicksurface.com)
  • Neuroendocrine neoplasms of the larynx arise from APUD (amine precursor uptake and decarboxylase) cells. (bvsalud.org)
  • An apudoma is any endocrine tumor that arises from an APUD cell (APUD, meaning amine precursor uptake and decarboxylation) properties. (naturalcurefor.com)
  • Amine precursor uptake and decarboxylation cells are known to give rise to islet cell tumors of the pancreas, medullary carcinomas of the thyroid, phaeochromocytomas, melanomas and carcinoid tumors. (naturalcurefor.com)
  • Taken together with previous studies, the properties of the type III cell of taste buds exactly fit into the APUD ( a mine and amine p recursor u ptake and d ecarboxylation) cell scheme. (springer.com)
  • Cells with the capacity to take up and decarboxylate the amine precursors DIHYDROXYPHENYLALANINE or 5-HYDROXYTRYPTOPHAN. (bvsalud.org)
  • D-cells produce trace amines [11,12], and may also act as an APUD (amine precursor uptake and decarboxylation) system that takes up amine precursors and converts them to amines by decarboxylation [13]. (scirp.org)
  • Because of secretory products by amine precursor uptake and decarboxylation (APUD) they are also known as APUDomas, which is more historical and no longer used. (radiopaedia.org)
  • Cellules 3 questions Endocrine cells found throughout the GASTROINTESTINAL TRACT and in islets of the PANCREAS. (lookformedical.com)
  • Neurons and pancreatic endocrine cells have a common physiology and express a similar toolkit of transcription factors during development. (frontiersin.org)
  • These findings suggest that pancreatic endocrine cells co-opted a regulatory signature from an ancestral neuron that was already present in an early-branched deuterostome. (frontiersin.org)
  • Some features are common to all endocrine cells, like the ability of producing polypeptide hormones ( 1 , 2 ), neurotransmitters and their receptors ( 3 , 8 ), while other are specific of pancreatic β-cells, like mRNA expression and chromatin methylation pattern similar to neurons ( 5 ). (frontiersin.org)
  • The endocrine system is a network of glands consisting of endocrine cells that produce hormones in the body. (encyclopedia.com)
  • The neuroendocrine system cells are specialized endocrine cells of the nervous system and produce neurohormones. (encyclopedia.com)
  • Facer P, Polak JM, Jaffe BM, Pearse AGE (1979) Immunocytochemical demonstration of 5-hydroxytryptamine in gastrointestinal endocrine cells. (springer.com)
  • This is a property of endocrine cells of neural and non-neural origin. (bvsalud.org)
  • NE cells have dual properties of neurons and endocrine cells and are believed to be involved in the regulation, secretion and differentiation of other prostatic cells [ 7 ]. (hindawi.com)
  • In addition, the clinical symptomatology and macroscopic/microscopic features of tumors arising from endocrine cells of the gastrointestinal tract are described, with an emphasis on their classification, diagnostic criteria for their grading and TNM (tumor, node, metastasis) staging, and how these tumors differ according to their localization in the gastrointestinal tract. (prolekare.cz)
  • Glomus type I cells are secretory sensory neurons that release neurotransmitters in response to hypoxemia (low pO2), hypercapnia (high pCO2) or acidosis (low pH). (wikipedia.org)
  • The glomus type I cells of the carotid body are innervated by the sensory neurons found in the inferior ganglion of the glossopharyngeal nerve. (wikipedia.org)
  • Centrally the axons of neurons which innervate glomus type I cells synapse in the caudal portion of the solitary nucleus in the medulla. (wikipedia.org)
  • amacrine cell any of five types of retinal neurons that seem to lack large axons, having only processes that resemble dendrites. (thefreedictionary.com)
  • To explain these common features, it has been hypothesized that pancreatic cells most likely co-opted a pre-existing gene regulatory program from ancestral neurons. (frontiersin.org)
  • Here, we find that the ectodermal SpLox+ SpBrn1/2/4 cells are specified as SpSoxC and SpPtf1a neuronal precursors that become the lateral ganglion and the apical organ neurons. (frontiersin.org)
  • Taken together, our data reveal that there is a subset of sea urchin larval neurons with a gene program that predated pancreatic cells. (frontiersin.org)
  • Pancreatic endocrine β-cells and neurons are an example of different cell types that share a similar gene program but exert different functions. (frontiersin.org)
  • Adult SD and HF NCSCs could actually go through aimed differentiation into neurons, Schwann cells, adipocytes, and osteoblasts. (ecologicalsgardens.com)
  • neurons to generate persistent firing through cell-autonomous biophysical mechanisms. (jneurosci.org)
  • Much of the intense interest in understanding cognitive functions is motivated by the hope that it might be possible to understand these complex functions at the level of neurons and neural circuits. (frontiersin.org)
  • In rodents [13,16,17], a small number of D-cells in the striatum were rostrally described and confirmed to be neurons by electron-microscopic observation [13]. (scirp.org)
  • Upon activation, EC cells release serotonin to act upon serotonin receptors on ENS neurons. (wikipedia.org)
  • The primary function of EC cells is to synthesise and secrete serotonin for modulation of gastrointestinal neurons. (wikipedia.org)
  • It has also been observed the presence of relatively small ganglions containing a reduced number of neurons and big ganglions containing a high number of these cells. (scielo.cl)
  • Endogenous glial cell line-derived neurotrophic factor (GDNF) has been shown to be anterogradely transported in sensory and motor neurons which do not express detectable levels of GDNF mRNA. (statescale.tk)
  • ICC also mediate neural input from enteric motor neurons . (wikidoc.org)
  • The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as glial cells) into neurons without introducing exogenous genes to the samples. (patentsencyclopedia.com)
  • This method is a simple and straightforward technique for tracing neural crest cells during migration and differentiation that are otherwise difficult to distinguish within an unmanipulated chick embryo. (jove.com)
  • The combined tumors and the numerous other similar neoplasms described in the literature and reviewed here suggest an endodermal origin for digestive and respiratory tract APUD cells based on the hypothesis that cancer is a clonal proliferation, and mucous and squamous cell differentiation is an endodermal rather than neural crest characteristic. (meta.org)
  • These results suggest that AADC expression begins at early stages of taste bud cell differentiation, and biogenic amines may act on taste bud differentiation of tongue epithelial cells, and further may regulate innervation of taste bud progenitor cells. (springer.com)
  • Thus our data demonstrates that VPA does not induce NE differentiation of PCa cells in the physiologically relevant in vivo setting. (hindawi.com)
  • HDAC inhibitors (HDACIs) have demonstrated significant antitumor activity by hyperacetylation of nucleosomal histones resulting in reexpression of repressed genes that produce growth arrest, terminal differentiation, and/or apoptosis in carcinoma cells [ 3 ]. (hindawi.com)
  • The characteristics of NE differentiation in PCa are very much similar to those seen in patients who develop this histologic phenotype in non-small-cell lung cancer [ 10 ]. (hindawi.com)
  • It also acts as protein binding, transcription factor, and in cell differentiation. (atlasgeneticsoncology.org)
  • Tumors arising from neuroendocrine cells are defined as epithelial neoplasms with predominantly neuroendocrine differentiation. (prolekare.cz)
  • 1. A stem cell comprising a transgene, wherein the transgene comprises a gene product, wherein the transgene is integrated into a specified region of the genome of the stem, cell such that gene product is transcribed or translated upon or during differentiation of the stem cell into a lineage-specific or mature cell type. (patentsencyclopedia.com)
  • It is classified according to degree of cell differentiation as acute or chronic, and according to predominant type of cell involved as myelogenous or lymphocytic. (lookformedical.com)
  • Pancreatic endocrine tumors (PETs) are also known as endocrine pancreatic tumors (EPTs) or islet cell tumors. (thefullwiki.org)
  • Pancreatic non-beta-cell hyperplasia is rare but has been reported in children. (medscape.com)
  • Pancreatic islet cell tumors arise from this system and are capable of secreting virtually any of the known polypeptide hormones. (springer.com)
  • Broder LE, Carter SK: Pancreatic islet cell carcinoma. (springer.com)
  • [ 1 ] In 1927, Wilder et al described the first hormone-producing pancreatic tumor syndrome in a patient with hypoglycemia and a metastatic islet cell tumor, extracts of which caused hypoglycemia. (medscape.com)
  • Although the term islet cell tumor is often used to identify neoplasms of the endocrine pancreas, this is a misnomer because many pancreatic neuroendocrine tumors do not develop directly from islet cells. (medscape.com)
  • acinar cell , acinic cell , acinous cell any of the cells lining an acinus, especially the zymogen-secreting cells of the pancreatic acini. (thefreedictionary.com)
  • 1. An enteroendocrine cell that produces glucagon and is found in the pancreatic islets. (thefreedictionary.com)
  • As such, symptoms and histology of pancreatic islet cell tumors and apudoma have striking similarities. (naturalcurefor.com)
  • Only vertebrates have a proper pancreas, however, our lab previously found that cells with a pancreatic-like signature are localized within the sea urchin embryonic gut. (frontiersin.org)
  • We also found that the pancreatic transcription factors Xlox/Pdx1 and Brn1/2/4 co-localize in a sub-population of ectodermal cells. (frontiersin.org)
  • Two of the SpLox+ SpBrn1/2/4 cells also express another pancreatic transcription factor, the LIM-homeodomain gene islet-1 . (frontiersin.org)
  • Many genes expressed in neuronal development are also expressed in the development of pancreatic β-cells ( 7 ), like the homeodomain protein Isl1 ( 9 ), the bHLH transcription factors neurogenins ( 10 - 12 ), and the homeobox transcription factor PDX1 ( 13 , 14 ). (frontiersin.org)
  • Because they can occur wherever neuroendocrine cells are found, neuroendocrine tumors come in a wide variety of types and have been classified according to their site of origin, usually either as digestive system , pancreatic or lung neuroendocrine tumors. (encyclopedia.com)
  • Functionally active neuroendocrine tumors display specific symptoms, such as the excessive release of specific neurohormones from the tumor cell, as described above for pancreatic neuroendocrine tumors. (encyclopedia.com)
  • Aoyagi T, Summerskill WHJ: Gastric secretion with ulcerogenic islet cell tumor: Importance of basal acid output. (springer.com)
  • basal cell an early keratinocyte, present in the stratum basale of the epidermis. (thefreedictionary.com)
  • basal granular cells APUD cells located at the base of the epithelium at many places in the gastrointestinal tract. (thefreedictionary.com)
  • Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. (meta.org)
  • Discover the latest research on basal cell carcinoma here. (meta.org)
  • Merkel cells (shown in blue) are located in the basal epidermal layer of the skin. (wikipedia.org)
  • Neuroendocrine (NE) cells are the third and minor epithelial cell type in prostate, in addition to the more abundant luminal secretory cells and basal cells [ 6 ]. (hindawi.com)
  • [6] EC cells typically extend down to the basal lamina with cytoplasmic extensions known to pass through the connective tissue and neighbouring glands. (wikipedia.org)
  • Neoplasms of glomus cells are known as paraganglioma, among other names, they are generally non-malignant. (wikipedia.org)
  • Neuroendocrine neoplasms of the larynx canbe divided into those of epithelial or neural origin. (bvsalud.org)
  • Neuroendocrine tumors are a heterogeneous group of neoplasms that arise from neuroendocrine cells. (biomedcentral.com)
  • Primary renal neuroendocrine tumors are among the most unusual of all renal neoplasms, since neuroendocrine cells are not found within normal renal parenchyma. (biomedcentral.com)
  • Neuroendocrine (NE) tumours include a heterogeneous group of neoplasms arising from NE cells, which are either present in endocrine organs or dispersed through the body, including the gastrointestinal tract, lung, kidney, ovary, testis, et al. (biomedcentral.com)
  • The new classification defines the entire group of tumors as neuroendocrine neoplasms (NENs), which have been confirmed to arise from the neuroendocrine cell system. (biomedcentral.com)
  • Pheochromocytomas are neoplasms arising from the catecholamine-producing, neural crest-derived chromaffin cells of the adrenal medulla, similar neoplasms can also arise from extramedullarychromaffin cells and are referred to as paragangliomas [2]. (thefreedictionary.com)
  • Tympanic paragangliomas are neuroendocrine neoplasms located in the middle ear and arising from chromaffin cells of the parasympathetic paraganglia. (thefreedictionary.com)
  • Pulmonary carcinoid tumors are malignant neoplasms comprising neuroendocrine cells that account for 2% to 5% of all lung cancers ( 2 ). (aacrjournals.org)
  • These lesions are rare neuroendocrine neoplasms that originate in specialized cells derived from the neural crest. (scielo.br)
  • Tumeurs 12 questions Neoplasms composed of squamous cells of the epithelium. (lookformedical.com)
  • Tumeurs Embryonnaires Et Germinales 0 questions Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO. (lookformedical.com)
  • Tumeurs Des Gaines Nerveuses 0 questions Neoplasms which arise from nerve sheaths formed by SCHWANN CELLS in the PERIPHERAL NERVOUS SYSTEM or by OLIGODENDROCYTES in the CENTRAL NERVOUS SYSTEM. (lookformedical.com)
  • Tumeurs Neuroectodermiques 0 questions Malignant neoplasms arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells. (lookformedical.com)
  • 1. Intro The neural crest (NC) can be a transient framework appearing through the embryonic advancement of [1] that's formed for the border between your somatic ectoderm as well as the neural dish [2]. (ecologicalsgardens.com)
  • They consist of a large heterogeneous group of malignancies that are derived from embryonic neural crest tissue found in various organ such as the hypothalamus, pituitary gland, thyroid gland, adrenal medulla, and gastrointestinal tract. (radiopaedia.org)
  • Persistent expression of BMP-4 in embryonic chick adrenal cortical cells and its role in chromaffin cell development," Neural Development, vol. (thefreedictionary.com)
  • 4. The stem cell of claim 1, wherein the stem cell is selected from the group consisting of a hematopoietic stem cell, a mesenchymal stem cell, an embryonic stem cell, a neuronal stem cell, a muscle stem cell, a liver stem cell, a skin stem cell, an induced pluripotent stem cell and combinations thereof. (patentsencyclopedia.com)
  • dePeyster FA: Planning the appropriate operations for islet cell tumors of the pancreas. (springer.com)
  • [ 13 ] APUD cells were once believed to originate from the embryologic neural crest, but current evidence suggests that these cells-and thus endocrine tumors of the pancreas and other endocrine tumors of the upper gastrointestinal tract (eg, carcinoid tumors)-actually develop from the embryologic endoderm. (medscape.com)
  • The cell division produces various cells for the development of different organs but all these cells arise initially from only 3 morphologically different germinal layers. (hpathy.com)
  • [ 15 ] Instead, the tumors arise from APUD stem cells, which are pluripotential neuroendocrine cells located within the ductular epithelium of the exocrine pancreas and elsewhere in the distal foregut. (medscape.com)
  • In mammals, all new cells arise from existing cells through cell division, and an animal's growth results largely from increases in the number of its cells, most of which differentiate into specialized cell types to form the body's various tissues. (thefreedictionary.com)
  • ICCs are thought to be the cells from which gastrointestinal stromal tumours (GISTs) arise. (wikidoc.org)
  • Neuroendocrine tumors are tumors that develop from the cells of the diffuse neuroendocrine system, such as the enterochromaffin (EC) cells. (encyclopedia.com)
  • Not to be confused with Enterochromaffin-like cell . (wikipedia.org)
  • Enterochromaffin (EC) cells (also known as Kulchitsky cells ) were discovered by Nikolai Kulchitsky of Karazin Kharkiv National University , Ukraine . (wikipedia.org)
  • Enterochromaffin-like (ECL) cells" are a population of cells that are found in the gastric pits of the stomach luminal epithelium and secrete histamine. (wikipedia.org)
  • They were historically thought to be derived from neural crest cells, but this has since been shown to be untrue (see neuroendocrine tumor). (wikipedia.org)
  • If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. (lookformedical.com)
  • Pathological diagnosis was high-grade small-cell neuroendocrine tumor. (biomedcentral.com)
  • Pathological diagnosis was low-grade small-cell neuroendocrine tumor with immuno-negativity for ACTH. (biomedcentral.com)
  • Morphological examination revealed that the tumor was comprised of different size cells with distinct atypia, which were arranged in disperse and sheet form and proliferated actively (Fig. 2a , b ). (biomedcentral.com)
  • The pathological diagnosis was high-grade small-cell neuroendocrine tumor (NET). (biomedcentral.com)
  • c - e Tumor cells were immunohistochemical positive for Syn ( c ), ChrA ( d ), and CK8 ( e ). f The Ki-67-labeling index was more than 90 % in the atypical cells. (biomedcentral.com)
  • A tissue microarray of VPA-treated and untreated tumor xenografts and cell lines of human PCa (LNCaP, C4-2, DU145, and PC-3) were generated and were analyzed by immunohistochemical analysis (IHC) for NE markers chromogranin A (CgA), synaptophysin, and NCAM (neural cell adhesion molecule). (hindawi.com)
  • Valproic Acid (VPA), an HDACI and an antiepileptic agent, causes marked decrease in proliferation of Prostate Cancer (PCa) cells in vitro and significant reduction in tumor volume in vivo [ 4 , 5 ]. (hindawi.com)
  • Such measurements not only avoid the quality assurance problems associated with measurements of deconjugated metanephrines, but also offer theoretical advantages related to measurements of free metabolites formed within chromaffin cells and their tumor derivatives (18, 23). (thefreedictionary.com)
  • Regardless of the chromaffin cell tumor location, high maternal, and fetal morbidity and mortality rates underscore the importance of establishing a diagnosis as early as possible. (thefreedictionary.com)
  • In pathology, an apudoma is an endocrine tumour that arises from an APUD cell from structures such as the ampulla of Vater. (wikipedia.org)
  • Neural crest cells are precursors of APUDoma and neurogenic cells. (medscape.com)
  • APUDOMA is a general term collectively applied to tumors associated with APUD cells. (slicksurface.com)
  • Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. (slicksurface.com)
  • Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium" (PDF). (wikipedia.org)
  • These tumors are characterized by the presence of cells that possess secretory granules and have the ability to secrete neurohormones. (encyclopedia.com)
  • Méningiome 0 questions A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. (lookformedical.com)
  • Two of the renal metastases showed small cell carcinoma. (meta.org)
  • It also includes cells that are not part of glands: the diffuse neuroendocrine system, scattered throughout other organs. (thefullwiki.org)
  • ABBR: APUD cell Any of the constituent cells of a diffuse neuroendocrine system, having metabolic pathways that make and utilize serotonin (5-HT). (tabers.com)
  • The latter consists of paragangliomas while the group of the epithelial origin can be further divided into typical and atypical carcinoids, and small cell neuroendocrine carcinoma, which consist of the oat cell type, the intermediate cell type and the combined cell type. (bvsalud.org)
  • Also presented are the histologic features of a carcinoma of the lung with large cell undifferentiated carcinoma, adenocarcinoma, squamous cell carcinoma, and giant cell carcinoma areas in the primary site and in several metastatic foci. (meta.org)
  • The ultrastructural features of tumors of cells of known neural crest origin, including a medullary carcinoma of the thyroid, three carotid body tumors, a pheochromocytoma, and two cutaneous melanomas were compared with those of other APUD cell tumors including small cell carcinomas of. (meta.org)
  • [1] Although uncommon, these cells may become malignant and form a Merkel cell carcinoma -an aggressive and difficult to treat skin cancer. (wikipedia.org)
  • Actinic keratosis is currently believed to be an early stage in the evolution of squamous cell carcinoma. (storysteel.gq)
  • Our results of double staining with AADC and taste cell markers indicate that only the type III cells could convert 5-hydroxytryptophan (5-HTP) to serotonin within taste buds. (springer.com)
  • Choi DS, Ward SJ, Messaddeq N, Launay JM, Maroteaux L (1997) 5-HT2B receptor-mediated serotonin morphogenetic function in mouse cranial neural crest and myocardial cells. (springer.com)
  • Herness S, Chen Y (1997) Serotonin inhibits calcium-activated K + current in rat taste receptor cells. (springer.com)
  • [2] EC cells modulate neuron signalling in the enteric nervous system (ENS) via the secretion of the neurotransmitter serotonin and other peptides. (wikipedia.org)
  • They are discriminated from other cells of the gastrointestinal epithelial crypts by the presence of basally located granulations that contain serotonin and other peptides. (wikipedia.org)
  • They are however a different cell type and do not possess any serotonin synthesizing mechanisms. (wikipedia.org)
  • Release of serotonin from EC cells can be triggered by a multitude of stimuli, particularly luminal distension, parasympathetic innervation or changes in osmotic concentrations in intestinal contents. (wikipedia.org)
  • Proper use of the light microscope to recognize cells, tissues and organs. (edu.ng)
  • Here, we report the development of a modified iDISCO-based protocol, iDISCO(ace), for whole-tissue 3D assessment of neural innervations and immune reactions in intact, unsectioned lung tissues. (sciencemag.org)
  • Malignancy is typically proven with demonstration of chromaffin cells in non-chromaffin tissues. (thefreedictionary.com)
  • Many types of smooth muscle tissues have now been shown to contain ICC, but with few exceptions the function of these cells is not known and an area of active research . (wikidoc.org)
  • Hamartomes 0 questions A focal malformation resembling a neoplasm, composed of an overgrowth of mature cells and tissues that normally occur in the affected area. (lookformedical.com)
  • Gonadal tissues include GERM CELLS, cells from the sex cord, and gonadal stromal cells. (lookformedical.com)
  • often restricted to the cells of the alveolar epithelium (squamous alveolar cells and great alveolar cells) and alveolar phagocytes. (thefreedictionary.com)
  • Arias-Stella cells columnar cells in the endometrial epithelium which have a hyperchromatic enlarged nucleus and which appear to be associated with chorionic tissue in an intrauterine or extrauterine site. (thefreedictionary.com)
  • APUD cells [ a mine p recursor u ptake and d ecarboxylation] a group of cells that manufacture polypeptides and biogenic amines serving as hormones or neurotransmitters. (thefreedictionary.com)
  • [1] These cells all together produce hormones of the anterior pituitary, and release them into the blood stream. (wikipedia.org)
  • In humans, lymphocytes are small cells (~6 µm in diameter), columnar epithelial cells (10 µm x 20 µm) are medium-size cells, and mature ova (120-150 µm) are some of the largest cells. (thefreedictionary.com)
  • 1. In the lung, either of two types of epithelial cells lining the alveoli. (thefreedictionary.com)
  • Type I cells are simple thin squamous epithelial cells. (thefreedictionary.com)
  • 2. In the mammary glands, the milk-secreting epithelial cells, which are activated during lactation. (thefreedictionary.com)
  • Cylindrical epithelial cells in the innermost layer of the ENAMEL ORGAN. (slicksurface.com)
  • In humans, lymphocytes are small cells (6 µm in diameter), columnar epithelial cells (10 µm x 20 µm) are medium-size cells, and mature ova (120 to 150 µm) are some of the largest cells. (tabers.com)
  • Furthermore, in the developing circumvallate papilla, AADC are first detected in a small number of papillary epithelial cells at E14.5. (springer.com)
  • By E18.5, AADC-positive epithelial cells also express PGP9.5, which is one of marker of taste cells, and these cells have been contacted by developing nerve fibers. (springer.com)
  • Merkel cells , also known as Merkel-Ranvier cells or tactile epithelial cells , are oval-shaped mechanoreceptors essential for light touch sensation and found in the skin of vertebrates. (wikipedia.org)
  • Pheochromocytomas are tumors that originate from chromaffin cells, which are specialized non-epithelial cells of the neural crest that are associated with sympathetic ganglia during fetal life. (scielo.br)
  • Primary renal neuroendocrine tumors are extremely rare in the world because neuroendocrine cells are not found in normal renal parenchyma, pelvis, and ureter. (biomedcentral.com)
  • Neuroendocrine tumors therefore represent a large class of cancers that can occur wherever neuroendocrine cells are found throughout the body. (encyclopedia.com)
  • Neuroendocrine tumors are also known as apudomas, or tumors that contain apud cells. (encyclopedia.com)
  • In contrast, studies done in neuroendocrine tumors such as carcinoid, pheochromocytoma, and small cell lung cancers have shown VPA and other HDACIs to exert antitumor effects [ 13 - 15 ]. (hindawi.com)
  • Paragangliomas are rare neuroendocrine tumors that originate in specialized cells derived from neural crest cells, affecting the region of the carotid or jugular-tympanic artery. (scielo.br)
  • [10] EC cells are believed to be derived from endodermal origins and are descended from the stem cells that form other epithelial cell types of the gastrointestinal lumen. (wikipedia.org)
  • Avior Y, Lezmi E, Eggan K , Benvenisty N. Cancer-Related Mutations Identified in Primed Human Pluripotent Stem Cells. (harvard.edu)
  • Avior Y, Eggan K , Benvenisty N. Retraction Notice to: Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells. (harvard.edu)
  • Kinetics of cytotoxicity of VM-26 and VP-16-213 on L1210 leukemia and hematopoietic stem cells. (statescale.tk)
  • Disclosed herein are methods and compositions for targeted integration of sequences of interest such as lineage-specific or cell fate reporter constructs or protein encoding sequences into stem cells. (patentsencyclopedia.com)
  • 13. A method of isolating cells of a selected cell type, the method comprising:culturing a population of stem cells according to claim 1, wherein the gene product is expressed in cells of the selected cell type and isolating the cells that express the gene product, thereby isolating cells of the selected type. (patentsencyclopedia.com)
  • 15. A method of producing a gene product in a stem cell, the method comprising:providing a population of stem cells according to claim 1, wherein the sequence is integrated into a non-essential site in the stem cells, andculturing the population of stem cells, wherein the population of cultured stem cells uniformly expresses the gene product. (patentsencyclopedia.com)
  • 16. A method of treating a disease characterized by reduced expression of a functional gene product in a subject in need of treatment, the method comprising:administering a population of stem cells according to claim 15 to the subject, wherein the stem cells express the functional gene product. (patentsencyclopedia.com)
  • However, how efferent neural signals influence lung immunity remains incompletely understood. (sciencemag.org)
  • Although CIN is the predominant form of genetic instability in most solid tumors including CRCs the molecular basis for CIN in malignancy cells remains incompletely understood. (bioinbrief.com)
  • The Ectoderm gives rise to cells that form tissue of organs that are exposed to the external environment. (hpathy.com)
  • 1. any of the protoplasmic masses making up organized tissue, consisting of a nucleus surrounded by cytoplasm enclosed in a cell or plasma membrane. (thefreedictionary.com)
  • The present invention relates to methods of enriching for desired cell population from cell sources, such as body fluids, dispersed tissue specimens and cultured cells. (freepatentsonline.com)
  • Cellules Cancéreuses En Culture 0 questions Cells grown in vitro from neoplastic tissue. (lookformedical.com)
  • Tissue beneath EC cells typically contains abundant fenestrated capillaries, lymph vessels and small unmyelinated nerve fibres. (wikipedia.org)
  • In developing chick embryos, EC cells have been found in biopsies of developing GIT tissue before the migration of neural crest cells. (wikipedia.org)
  • 10. The stem cell of claim 7, wherein the sequence encoding the protein is expressed constitutively, inducibely or tissue-specifically. (patentsencyclopedia.com)
  • The signalling within the chemoreceptors is thought to be mediated by the release of neurotransmitters by the glomus cells, including dopamine, noradrenaline, acetylcholine, substance P, vasoactive intestinal peptide and enkephalins. (wikipedia.org)
  • Placebos trigger the release of certain neurotransmitters-chemicals that carry messages throughout the neural circuitry and activate the brain's reward system-thereby leading to improvements in a variety of diseases. (nautil.us)
  • Follicular dendritic cells (DENDRITIC CELLS, FOLLICULAR) are also considered to be antigen-presenting cells by some authors. (slicksurface.com)
  • basket cell a neuron of the cerebral cortex whose fibers form a basket-like nest in which a Purkinje cell rests. (thefreedictionary.com)
  • A somatic motor neuron that has its cell body in the ventral (anterior) horn of the gray matter of the spinal cord. (tabers.com)
  • NE cells in prostate express NE markers such as Chromogranin A (CgA), synaptophysin, B-tubulin, neural cell adhesion molecule (NCAM or CD56), neuron specific enolase (NSE), and so forth. (hindawi.com)
  • Furthermore, glomus cells are highly responsive to angiotensin II through AT1 receptors, providing information about the body's fluid and electrolyte status. (wikipedia.org)
  • In order to understand the effects of prefrontal DA release on neural activity, first let us consider DA receptors and the anatomy of DA-ergic terminals in PFC. (frontiersin.org)
  • Twenty-seven small cell carcinomas of the lung and three tumors of the large intestine with combined adenocarcinomatous and small cell and/or anaplastic carcinoid-type histologic features were studied by light and electron microscopy. (meta.org)
  • Small cell PCa and prostatic carcinoid are relatively rare and are considered pure NE tumors with a poor prognosis [ 8 ]. (hindawi.com)
  • Tumors arising from neuroendocrine cells are rare and can cause typical symptoms of carcinoid syndrome. (prolekare.cz)
  • Biochemical analysis of lung carcinoid cell lines was used to investigate EGFR signal transduction and response to erlotinib inhibition. (aacrjournals.org)
  • Using a lung carcinoid cell line that expresses EGFR, we found that erlotinib reduced proliferation by inhibiting EGFR signal transduction. (aacrjournals.org)
  • Pheochromocytoma is a rare neuroendocrine tumour derived from chromaffin cells of the adrenal gland. (thefreedictionary.com)
  • Pheochromocytoma is a rare catecholamine secreting tumour which is of chromaffin cells of adrenal medulla (90%) or extra-adrenal sympathetic para-ganglia. (thefreedictionary.com)
  • Whilst EC cells have neuroendocrine properties and are similar chemically and histologically to cells of the adrenal medulla they are not derivatives of the neural crest and do not share a similar cell progenitor. (wikipedia.org)
  • Cena, "Adrenal medulla calcium channel population is not conserved in bovine chromaffin cells in culture," Neuroscience, vol. (thefreedictionary.com)
  • After birth, most of these cells degenerate and the largest numbers of residual chromaffin cells remain in the adrenal medulla (3,4-8) . (scielo.br)
  • For example, the hormone insulin , secreted by the pancreas , acts primarily to allow glucose to enter the body's cells for use as fuel. (thefullwiki.org)
  • Alpha cell of the pancreas. (thefreedictionary.com)
  • A cell present in the acinus of an acinous gland, e.g., of the pancreas. (thefreedictionary.com)
  • These cells, which are derived from neural crest cells, are from structures such as the prostate, pancreas and ampulla of Vater. (naturalcurefor.com)
  • While all deuterostomes have a nervous system, the discrete pancreas with fully-developed β-cells is a vertebrate specific organ ( 16 ). (frontiersin.org)
  • It is highly expressed in medullary thyroid cancer (MTC) and small cell lung cancer (SCLC) and may be a useful marker for these cancers. (atlasgeneticsoncology.org)
  • The endodermal origin of digestive and respiratory tract APUD cells. (meta.org)
  • However, the origin and displacement of the prospective endodermal cells during crucial periods in gastrulation remain unclear. (biologists.org)
  • First, we determined the primitive-streak origin of the endoderm using supravital fluorescent markers, and followed the movement of the prospective endodermal cells as they dispersed to generate the definitive endodermal layer. (biologists.org)
  • Second, the question of the epiblast origin of the endodermal layer was addressed by precisely labeling epiblast cells in a region known to give rise to prospective somitic cells, and following their movement as they underwent ingression through the primitive streak. (biologists.org)
  • We show that the epiblast clearly contributes prospective endodermal cells to the primitive streak, and subsequently to definitive endoderm of the area pellucida. (biologists.org)
  • We show that as the definitive endodermal layer is laid down, there is cell-cell intercalation at its interface with the displaced hypoblast cells. (biologists.org)
  • These data were used to construct detailed prospective fate maps of the endoderm in the chick embryo, delineating the origins and migrations of endodermal cells in various rostrocaudal levels of the primitive streak during key periods in early development. (biologists.org)
  • An approach for analyzing migration and eventual fate of avian neural crest cells in quail-chick chimeric embryos is described. (jove.com)
  • In mammalian and avian embryos, gastrulation is centered around the primitive streak, a transient midline structure that serves as a conduit through which epiblast cells fated to become mesoderm and endoderm ingress to establish the germ layers. (biologists.org)
  • Cellules De La Moelle Osseuse 0 questions Cells contained in the bone marrow including fat cells (see ADIPOCYTES), STROMAL CELLS, MEGAKARYOCYTES, and the immediate precursors of most blood cells. (lookformedical.com)
  • Pluripotential hormone-secreting cells belonging to the APUD cell system (see p. 132) are distributed throughout the human foregut and its endocrine derivatives [75]. (springer.com)
  • Not only do the prospective fate maps generated from these studies suggest mechanisms underlying cell commitment and patterning of the early vertebrate embryo, they also provide insight into morphogenesis as a whole. (biologists.org)
  • ICC also express mechano-sensitive mechanisms that cause these cells to respond to stretch. (wikidoc.org)
  • A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. (slicksurface.com)
  • This would involve the study of the gross anatomy of the central nervous system including the brain, spinal cord and neural pathways, and the nuclei of origin, intracranial and extra cranial course. (edu.ng)
  • The localizations of D-cells were specified into 14 groups, from D1 (the spinal cord) to D14 (the bed nucleus of stria terminalis), in caudo-rostral orders of the rat central nervous system, using AADC immunohistochemistry [14,15]. (scirp.org)
  • Pulmonary neuroendocrine cells in the respiratory tract are known as bronchial Kulchitsky cells . (wikipedia.org)
  • Glomus type II cells are sustentacular cells having a similar supportive function to glial cells. (wikipedia.org)
  • Extensive studies in the field have been focused on distinct types of immune cells, e.g., alveolar macrophages, subtypes of T lymphocytes, and innate lymphoid cells (ILCs), in the regulation of lung immune responses ( 9 - 13 ). (sciencemag.org)
  • All of these aspects lead to the idea that gut cells co-opted a neuronal transcriptional program leading to the evolution of β-cells ( 15 ). (frontiersin.org)
  • Therefore, gut cells must have adopted part of a neuronal program before the vertebrate ancestor appeared. (frontiersin.org)
  • When did gut cells adopt a neuronal program? (frontiersin.org)
  • That is especially valid for the neuronal cellular population, wheather for its functional meaning or because when they are destroyed, these nerve cells can never be restored. (scielo.cl)
  • In the prefrontal cortex (PFC), these changes were shown to be related to decreases in neuronal cell size and neuropil volume but not to a reduction in cell numbers (1). (schoolbag.info)
  • A precursor cell that can also give rise to identical precursor cells: daughters of a stem cell can develop into a terminally-differentiated cell type or they can remain a stem cell. (thefreedictionary.com)
  • A precursor cell that can also give rise to identical precursor cells. (tabers.com)
  • Identification of precursor cells that ingress through the primitive streak, and tracking of their subsequent movement to various destinations in the developing embryo, have been the subjects of intense research. (biologists.org)
  • Subjects with myelopathy or cauda equina syndrome, defined as neural compression causing neurogenic bowel (rectal incontinence) or bladder dysfunction (retention or incontinence). (tripdatabase.com)
  • 10] in 1983, in the rat central nervous system, and was defined "non-monoaminergic aromatic L-amino acid decarboxylase (AADC)-containing cells" [10]. (scirp.org)
  • Vale, W., and Rivier, C., 1977, Effects of a putative hypothalamic CRF and known substances on the secretion of radioimmunoassayable ACTH by cultured anterior pituitary cells, Proceedings of the Endocrine Society 59th Meeting , p. 217 (abstract). (springer.com)
  • The presence of ECL cells is critical in regulation of endocrine-induced gastric acid secretion. (wikipedia.org)
  • It is expected that the neural plasticity of the visual system can contribute to an ever-improving correlation between the physical world and evoked phosphenes. (utah.edu)
  • In all animals, the fleshy, glandular anterior pituitary is distinct from the neural composition of the posterior pituitary . (wikipedia.org)
  • The origin of Merkel cells has been debated for over 20 years. (wikipedia.org)
  • Evidence from skin graft experiments in birds implies that they are neural crest derived, but experiments in mammals now demonstrate an epidermal origin. (wikipedia.org)
  • Recipients of cells from antigen-primed donors responded to antigen stimulation with antibody of donor origin, showing that cells were effectively triggered for antibody production in the recipient. (storysteel.gq)
  • NENs are shared with marker proteins of neuroendocrine cell system [ 7 , 9 , 10 ], and they are further categorized into neuroendocrine carcinomas (NECs) and NETs. (biomedcentral.com)
  • B cells B lymphocytes . (thefreedictionary.com)
  • Various cell subpopulations, often B-lymphocytes, can be defined, based on the different classes of immunoglobulins that they synthesize. (slicksurface.com)
  • They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (slicksurface.com)
  • accessory cells macrophages involved in the processing and presentation of antigens, making them more immunogenic. (thefreedictionary.com)