Nerve Tissue
Sciatic Nerve
Peripheral Nerves
Neoplasms, Nerve Tissue
Optic Nerve
Organic Chemistry Phenomena
Optical Imaging
Nanofibers
Schwann Cells
Maillard Reaction
Tissue Scaffolds
Connective Tissue
Nerve Fibers
Proteins
Carbonic Anhydrase III
Protein Biosynthesis
Spinal Cord
Muscle Proteins
Liver
Nerve Block
Nitrogen
Nerve Endings
Sural Nerve
Median Nerve
Facial Nerve
Amino Acids
Tibial Nerve
Ulnar Nerve
Blood Proteins
Immunohistochemistry
Femoral Nerve
Glycosylation End Products, Advanced
Spinal Nerves
Muscle, Skeletal
Collagen
Dietary Proteins
Nerve Growth Factor
Trigeminal Nerve
Nerve Growth Factors
Swine
Neurons
Phrenic Nerve
Body Weight
Radial Nerve
Cranial Nerves
Phenylalanine
Cells, Cultured
Spinal Nerve Roots
Nerve Compression Syndromes
Rats, Wistar
Rats, Inbred Strains
Carbon Isotopes
Skin
Ophthalmic Nerve
Mandibular Nerve
Rats, Sprague-Dawley
Tissue Distribution
Cochlear Nerve
Splanchnic Nerves
Cattle
Glossopharyngeal Nerve
Mass Spectrometry
Neural Conduction
Optic Nerve Injuries
Optic Nerve Diseases
Myocardium
Thoracic Nerves
Nerve Fibers, Myelinated
Accessory Nerve
Kidney
Electrophoresis, Polyacrylamide Gel
Facial Nerve Injuries
Oxidation-Reduction
Abducens Nerve
Oculomotor Nerve
Aging
Sympathetic Nervous System
Cranial Nerve Neoplasms
Facial Nerve Diseases
FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. (1/25163)
Beads containing recombinant FGF8 (FGF8-beads) were implanted in the prospective caudal diencephalon or midbrain of chick embryos at stages 9-12. This induced the neuroepithelium rostral and caudal to the FGF8-bead to form two ectopic, mirror-image midbrains. Furthermore, cells in direct contact with the bead formed an outgrowth that protruded laterally from the neural tube. Tissue within such lateral outgrowths developed proximally into isthmic nuclei and distally into a cerebellum-like structure. These morphogenetic effects were apparently due to FGF8-mediated changes in gene expression in the vicinity of the bead, including a repressive effect on Otx2 and an inductive effect on En1, Fgf8 and Wnt1 expression. The ectopic Fgf8 and Wnt1 expression domains formed nearly complete concentric rings around the FGF8-bead, with the Wnt1 ring outermost. These observations suggest that FGF8 induces the formation of a ring-like ectopic signaling center (organizer) in the lateral wall of the brain, similar to the one that normally encircles the neural tube at the isthmic constriction, which is located at the boundary between the prospective midbrain and hindbrain. This ectopic isthmic organizer apparently sends long-range patterning signals both rostrally and caudally, resulting in the development of the two ectopic midbrains. Interestingly, our data suggest that these inductive signals spread readily in a caudal direction, but are inhibited from spreading rostrally across diencephalic neuromere boundaries. These results provide insights into the mechanism by which FGF8 induces an ectopic organizer and suggest that a negative feedback loop between Fgf8 and Otx2 plays a key role in patterning the midbrain and anterior hindbrain. (+info)Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization. (2/25163)
The Drosophila Inscuteable protein acts as a key regulator of asymmetric cell division during the development of the nervous system [1] [2]. In neuroblasts, Inscuteable localizes into an apical cortical crescent during late interphase and most of mitosis. During mitosis, Inscuteable is required for the correct apical-basal orientation of the mitotic spindle and for the asymmetric segregation of the proteins Numb [3] [4] [5], Prospero [5] [6] [7] and Miranda [8] [9] into the basal daughter cell. When Inscuteable is ectopically expressed in epidermal cells, which normally orient their mitotic spindle parallel to the embryo surface, these cells reorient their mitotic spindle and divide perpendicularly to the surface [1]. Like the Inscuteable protein, the inscuteable RNA is asymmetrically localized [10]. We show here that inscuteable RNA localization is not required for Inscuteable protein localization. We found that a central 364 amino acid domain - the Inscuteable asymmetry domain - was necessary and sufficient for Inscuteable localization and function. Within this domain, a separate 100 amino acid region was required for asymmetric localization along the cortex, whereas a 158 amino acid region directed localization to the cell cortex. The same 158 amino acid fragment could localize asymmetrically when coexpressed with the full-length protein, however, and could bind to Inscuteable in vitro, suggesting that this domain may be involved in the self-association of Inscuteable in vivo. (+info)p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis. (3/25163)
p38 mitogen-activated protein kinase (p38) has been extensively studied as a stress-responsive kinase, but its role in development remains unknown. The fruit fly, Drosophila melanogaster, has two p38 genes, D-p38a and D-p38b. To elucidate the developmental function of the Drosophila p38's, we used various genetic and pharmacological manipulations to interfere with their functions: expression of a dominant-negative form of D-p38b, expression of antisense D-p38b RNA, reduction of the D-p38 gene dosage, and treatment with the p38 inhibitor SB203580. Expression of a dominant-negative D-p38b in the wing imaginal disc caused a decapentaplegic (dpp)-like phenotype and enhanced the phenotype of a dpp mutant. Dpp is a secretory ligand belonging to the transforming growth factor beta superfamily which triggers various morphogenetic processes through interaction with the receptor Thick veins (Tkv). Inhibition of D-p38b function also caused the suppression of the wing phenotype induced by constitutively active Tkv (TkvCA). Mosaic analysis revealed that D-p38b regulates the Tkv-dependent transcription of the optomotor-blind (omb) gene in non-Dpp-producing cells, indicating that the site of D-p38b action is downstream of Tkv. Furthermore, forced expression of TkvCA induced an increase in the phosphorylated active form(s) of D-p38(s). These results demonstrate that p38, in addition to its role as a transducer of emergency stress signaling, may function to modulate Dpp signaling. (+info)Conserved domains and lack of evidence for polyglutamine length polymorphism in the chicken homolog of the Machado-Joseph disease gene product ataxin-3. (4/25163)
Ataxin-3 is a protein of unknown function which is mutated in Machado-Joseph disease by expansion of a genetically unstable CAG repeat encoding polyglutamine. By analysis of chicken ataxin-3 we were able to identify four conserved domains of the protein and detected widespread expression in chicken tissues. In the first such analysis in a non-primate species we found that in contrast to primates, the chicken CAG repeat is short and genetically stable. (+info)A processive single-headed motor: kinesin superfamily protein KIF1A. (5/25163)
A single kinesin molecule can move "processively" along a microtubule for more than 1 micrometer before detaching from it. The prevailing explanation for this processive movement is the "walking model," which envisions that each of two motor domains (heads) of the kinesin molecule binds coordinately to the microtubule. This implies that each kinesin molecule must have two heads to "walk" and that a single-headed kinesin could not move processively. Here, a motor-domain construct of KIF1A, a single-headed kinesin superfamily protein, was shown to move processively along the microtubule for more than 1 micrometer. The movement along the microtubules was stochastic and fitted a biased Brownian-movement model. (+info)A concise promoter region of the heart fatty acid-binding protein gene dictates tissue-appropriate expression. (6/25163)
The heart fatty acid-binding protein (HFABP) is a member of a family of binding proteins with distinct tissue distributions and diverse roles in fatty acid metabolism, trafficking, and signaling. Other members of this family have been shown to possess concise promoter regions that direct appropriate tissue-specific expression. The basis for the specific expression of the HFABP has not been previously evaluated, and the mechanisms governing expression of metabolic genes in the heart are not completely understood. We used transient and permanent transfections in ventricular myocytes, skeletal myocytes, and nonmyocytic cells to map regulatory elements in the HFABP promoter, and audited results in transgenic mice. Appropriate tissue-specific expression in cell culture and in transgenic mice was dictated by 1.2 kb of the 5'-flanking sequence of FABP3, the HFABP gene. Comparison of orthologous murine and human genomic sequences demonstrated multiple regions of near-identity within this promoter region, including a CArG-like element close to the TATA box. Binding and transactivation studies demonstrated that this element can function as an atypical myocyte enhancer-binding factor 2 site. Interactions with adjacent sites are likely to be necessary for fully appropriate, tissue-specific, developmental and metabolic regulation. (+info)Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. (7/25163)
-The increased delivery of serotonin (5-hydroxytryptamine, 5-HT) to the lung aggravates the development of hypoxia-induced pulmonary hypertension in rats, possibly through stimulation of the proliferation of pulmonary artery smooth muscle cells (PA-SMCs). In cultured rat PA-SMCs, 5-HT (10(-8) to 10(-6) mol/L) induced DNA synthesis and potentiated the mitogenic effect of platelet-derived growth factor-BB (10 ng/mL). This effect was dependent on the 5-HT transporter (5-HTT), since it was prevented by the 5-HTT inhibitors fluoxetine (10(-6) mol/L) and paroxetine (10(-7) mol/L), but it was unaltered by ketanserin (10(-6) mol/L), a 5-HT2A receptor antagonist. In PA-SMCs exposed to hypoxia, the levels of 5-HTT mRNA (measured by competitive reverse transcriptase-polymerase chain reaction) increased by 240% within 2 hours, followed by a 3-fold increase in the uptake of [3H]5-HT at 24 hours. Cotransfection of the cells with a construct of human 5-HTT promoter-luciferase gene reporter and of pCMV-beta-galactosidase gene allowed the demonstration that exposure of cells to hypoxia produced a 5.5-fold increase in luciferase activity, with no change in beta-galactosidase activity. The increased expression of 5-HTT in hypoxic cells was associated with a greater mitogenic response to 5-HT (10(-8) to 10(-6) mol/L) in the absence as well as in the presence of platelet-derived growth factor-BB. 5-HTT expression assessed by quantitative reverse transcriptase-polymerase chain reaction and in situ hybridization in the lungs was found to predominate in the media of pulmonary artery, in which a marked increase was noted in rats that had been exposed to hypoxia for 15 days. These data show that in vitro and in vivo exposure to hypoxia induces, via a transcriptional mechanism, 5-HTT expression in PA-SMCs, and that this effect contributes to the stimulatory action of 5-HT on PA-SMC proliferation. In vivo expression of 5-HTT by PA-SMC may play a key role in serotonin-mediated pulmonary vascular remodeling. (+info)Functional consequences of mutations in the human alpha1A calcium channel subunit linked to familial hemiplegic migraine. (8/25163)
Mutations in alpha1A, the pore-forming subunit of P/Q-type calcium channels, are linked to several human diseases, including familial hemiplegic migraine (FHM). We introduced the four missense mutations linked to FHM into human alpha1A-2 subunits and investigated their functional consequences after expression in human embryonic kidney 293 cells. By combining single-channel and whole-cell patch-clamp recordings, we show that all four mutations affect both the biophysical properties and the density of functional channels. Mutation R192Q in the S4 segment of domain I increased the density of functional P/Q-type channels and their open probability. Mutation T666M in the pore loop of domain II decreased both the density of functional channels and their unitary conductance (from 20 to 11 pS). Mutations V714A and I1815L in the S6 segments of domains II and IV shifted the voltage range of activation toward more negative voltages, increased both the open probability and the rate of recovery from inactivation, and decreased the density of functional channels. Mutation V714A decreased the single-channel conductance to 16 pS. Strikingly, the reduction in single-channel conductance induced by mutations T666M and V714A was not observed in some patches or periods of activity, suggesting that the abnormal channel may switch on and off, perhaps depending on some unknown factor. Our data show that the FHM mutations can lead to both gain- and loss-of-function of human P/Q-type calcium channels. (+info)Neoplasms, nerve tissue can be caused by a variety of factors, such as genetic mutations, exposure to certain chemicals or radiation, or viral infections. Some common types of neoplasms, nerve tissue include:
1. Neurofibromas: These are benign tumors that grow on the nerve sheath and can cause symptoms such as numbness, weakness, or pain.
2. Schwannomas: These are benign tumors that grow on the covering of the nerves and can cause similar symptoms as neurofibromas.
3. Meningiomas: These are benign tumors that grow on the membranes that cover the brain and spinal cord.
4. Neurilemmomas: These are rare, benign tumors that grow on the covering of the nerves.
5. Malignant peripheral nerve sheath tumors (MPNSTs): These are rare, malignant tumors that can grow on the nerve sheath and can cause symptoms such as pain, weakness, or numbness.
6. Gangliocytomas: These are rare, benign tumors that grow on the nerve cells.
7. Plexiform neurofibromas: These are rare, benign tumors that grow on the nerve cells and can cause symptoms such as pain, weakness, or numbness.
Neoplasms, nerve tissue can be diagnosed through a variety of methods, including imaging tests such as MRI or CT scans, and tissue biopsy. Treatment options depend on the type and location of the tumor, and may include surgery, radiation therapy, or chemotherapy.
The symptoms of Sarcoma, Yoshida can vary depending on the location of the tumor, but may include pain, swelling, and limited mobility in the affected limb. The diagnosis of this condition is based on a combination of imaging studies such as CT or MRI scans, and a biopsy to confirm the presence of cancer cells.
Treatment for Sarcoma, Yoshida usually involves a combination of surgery, chemotherapy, and radiation therapy. The prognosis for this condition is generally poor, with a five-year survival rate of around 30%. However, early detection and aggressive treatment can improve outcomes.
Types of Peripheral Nerve Injuries:
1. Traumatic Nerve Injury: This type of injury occurs due to direct trauma to the nerve, such as a blow or a crush injury.
2. Compression Neuropathy: This type of injury occurs when a nerve is compressed or pinched, leading to damage or disruption of the nerve signal.
3. Stretch Injury: This type of injury occurs when a nerve is stretched or overstretched, leading to damage or disruption of the nerve signal.
4. Entrapment Neuropathy: This type of injury occurs when a nerve is compressed or trapped between two structures, leading to damage or disruption of the nerve signal.
Symptoms of Peripheral Nerve Injuries:
1. Weakness or paralysis of specific muscle groups
2. Numbness or tingling in the affected area
3. Pain or burning sensation in the affected area
4. Difficulty with balance and coordination
5. Abnormal reflexes
6. Incontinence or other bladder or bowel problems
Causes of Peripheral Nerve Injuries:
1. Trauma, such as a car accident or fall
2. Sports injuries
3. Repetitive strain injuries, such as those caused by repetitive motions in the workplace or during sports activities
4. Compression or entrapment of nerves, such as carpal tunnel syndrome or tarsal tunnel syndrome
5. Infections, such as Lyme disease or diphtheria
6. Tumors or cysts that compress or damage nerves
7. Vitamin deficiencies, such as vitamin B12 deficiency
8. Autoimmune disorders, such as rheumatoid arthritis or lupus
9. Toxins, such as heavy metals or certain chemicals
Treatment of Peripheral Nerve Injuries:
1. Physical therapy to improve strength and range of motion
2. Medications to manage pain and inflammation
3. Surgery to release compressed nerves or repair damaged nerves
4. Electrical stimulation therapy to promote nerve regeneration
5. Platelet-rich plasma (PRP) therapy to stimulate healing
6. Stem cell therapy to promote nerve regeneration
7. Injection of botulinum toxin to relieve pain and reduce muscle spasticity
8. Orthotics or assistive devices to improve mobility and function
It is important to seek medical attention if you experience any symptoms of a peripheral nerve injury, as early diagnosis and treatment can help prevent long-term damage and improve outcomes.
Body weight is an important health indicator, as it can affect an individual's risk for certain medical conditions, such as obesity, diabetes, and cardiovascular disease. Maintaining a healthy body weight is essential for overall health and well-being, and there are many ways to do so, including a balanced diet, regular exercise, and other lifestyle changes.
There are several ways to measure body weight, including:
1. Scale: This is the most common method of measuring body weight, and it involves standing on a scale that displays the individual's weight in kg or lb.
2. Body fat calipers: These are used to measure body fat percentage by pinching the skin at specific points on the body.
3. Skinfold measurements: This method involves measuring the thickness of the skin folds at specific points on the body to estimate body fat percentage.
4. Bioelectrical impedance analysis (BIA): This is a non-invasive method that uses electrical impulses to measure body fat percentage.
5. Dual-energy X-ray absorptiometry (DXA): This is a more accurate method of measuring body composition, including bone density and body fat percentage.
It's important to note that body weight can fluctuate throughout the day due to factors such as water retention, so it's best to measure body weight at the same time each day for the most accurate results. Additionally, it's important to use a reliable scale or measuring tool to ensure accurate measurements.
There are several types of nerve compression syndromes, including:
1. Carpal tunnel syndrome: Compression of the median nerve in the wrist, commonly caused by repetitive motion or injury.
2. Tarsal tunnel syndrome: Compression of the posterior tibial nerve in the ankle, similar to carpal tunnel syndrome but affecting the lower leg.
3. Cubital tunnel syndrome: Compression of the ulnar nerve at the elbow, often caused by repetitive leaning or bending.
4. Thoracic outlet syndrome: Compression of the nerves and blood vessels that pass through the thoracic outlet (the space between the neck and shoulder), often caused by poor posture or injury.
5. Peripheral neuropathy: A broader term for damage to the peripheral nerves, often caused by diabetes, vitamin deficiencies, or other systemic conditions.
6. Meralgia paresthetica: Compression of the lateral femoral cutaneous nerve in the thigh, commonly caused by direct trauma or compression from a tight waistband or clothing.
7. Morton's neuroma: Compression of the plantar digital nerves between the toes, often caused by poorly fitting shoes or repetitive stress on the feet.
8. Neuralgia: A general term for pain or numbness caused by damage or irritation to a nerve, often associated with chronic conditions such as shingles or postherpetic neuralgia.
9. Trigeminal neuralgia: A condition characterized by recurring episodes of sudden, extreme pain in the face, often caused by compression or irritation of the trigeminal nerve.
10. Neuropathic pain: Pain that occurs as a result of damage or dysfunction of the nervous system, often accompanied by other symptoms such as numbness, tingling, or weakness.
Types of Optic Nerve Injuries:
1. Traumatic optic neuropathy: This type of injury is caused by direct damage to the optic nerve as a result of trauma, such as a car accident or sports injury.
2. Ischemic optic neuropathy: This type of injury is caused by a lack of blood flow to the optic nerve, which can lead to cell death and vision loss.
3. Inflammatory optic neuropathy: This type of injury is caused by inflammation of the optic nerve, which can be caused by conditions such as multiple sclerosis or sarcoidosis.
4. Tumor-induced optic neuropathy: This type of injury is caused by a tumor that compresses or damages the optic nerve.
5. Congenital optic nerve disorders: These are present at birth and can cause vision loss or blindness. Examples include optic nerve hypoplasia and coloboma.
Symptoms of Optic Nerve Injuries:
* Blurred vision or double vision
* Loss of peripheral vision
* Difficulty seeing in dim lighting
* Pain or discomfort in the eye or head
* Redness or swelling of the eye
Diagnosis and Treatment of Optic Nerve Injuries:
Diagnosis is typically made through a combination of physical examination, imaging tests such as MRI or CT scans, and visual field testing. Treatment depends on the underlying cause of the injury, but may include medication, surgery, or vision rehabilitation. In some cases, vision loss may be permanent, but early diagnosis and treatment can help to minimize the extent of the damage.
Prognosis for Optic Nerve Injuries:
The prognosis for optic nerve injuries varies depending on the underlying cause and severity of the injury. In some cases, vision may be partially or fully restored with treatment. However, in other cases, vision loss may be permanent. It is important to seek medical attention immediately if any symptoms of an optic nerve injury are present, as early diagnosis and treatment can improve outcomes.
There are several types of facial nerve injuries, including:
1. Bell's palsy: This is a condition that affects the facial nerve and causes weakness or paralysis of the muscles on one side of the face. It is often temporary and resolves on its own within a few weeks.
2. Facial paralysis: This is a condition in which the facial nerve is damaged, leading to weakness or paralysis of the muscles of facial expression. It can be caused by trauma, tumors, or viral infections.
3. Ramsay Hunt syndrome: This is a rare condition that occurs when the facial nerve is affected by a virus, leading to symptoms such as facial paralysis and pain in the ear.
4. Traumatic facial nerve injury: This can occur as a result of trauma to the head or face, such as a car accident or a fall.
5. Tumor-related facial nerve injury: In some cases, tumors can grow on the facial nerve and cause damage.
6. Ischemic facial nerve injury: This occurs when there is a reduction in blood flow to the facial nerve, leading to damage to the nerve fibers.
7. Neurofibromatosis type 2: This is a rare genetic disorder that can cause tumors to grow on the facial nerve, leading to damage and weakness of the facial muscles.
Treatment for facial nerve injuries depends on the underlying cause and severity of the injury. In some cases, physical therapy may be recommended to help regain strength and control of the facial muscles. Surgery may also be necessary in some cases to repair damaged nerve fibers or remove tumors.
The symptoms of cranial nerve neoplasms depend on the location and size of the tumor, but may include:
* Headaches
* Pain in the face or head
* Numbness or weakness in the arms or legs
* Difficulty with vision, hearing, or balance
* Double vision
* Nausea and vomiting
Cranial nerve neoplasms can be diagnosed through a variety of tests, including:
* Imaging studies such as MRI or CT scans
* Biopsy, where a sample of tissue is removed for examination under a microscope
* Neurological examination to assess vision, hearing, balance, and other functions.
Treatment options for cranial nerve neoplasms depend on the location, size, and type of tumor, as well as the patient's overall health. Treatment may include:
* Surgery to remove the tumor
* Radiation therapy to kill any remaining cancer cells
* Chemotherapy to kill cancer cells
* Targeted therapy to attack specific molecules on the surface of cancer cells
* Observation, with regular monitoring and check-ups to see if the tumor is growing or changing.
It's important to note that cranial nerve neoplasms are relatively rare, and the prognosis and treatment options can vary depending on the specific type of tumor and the patient's overall health. A healthcare professional should be consulted for an accurate diagnosis and appropriate treatment plan.
Some examples of Facial Nerve Diseases include:
* Bell's Palsy: A condition that causes weakness or paralysis of the facial muscles on one side of the face, often resulting in drooping or twitching of the eyelid and facial muscles.
* Facial Spasm: A condition characterized by involuntary contractions of the facial muscles, which can cause twitching or spasms.
* Progressive Bulbar Palsy (PBP): A rare disorder that affects the brain and spinal cord, leading to weakness and wasting of the muscles in the face, tongue, and throat.
* Parry-Romberg Syndrome: A rare condition characterized by progressive atrophy of the facial muscles on one side of the face, leading to a characteristic "smile" or "grimace."
* Moebius Syndrome: A rare neurological disorder that affects the nerves responsible for controlling eye movements and facial expressions.
* Trauma to the Facial Nerve: Damage to the facial nerve can result in weakness or paralysis of the facial muscles, depending on the severity of the injury.
These are just a few examples of Facial Nerve Diseases, and there are many other conditions that can affect the facial nerve and cause similar symptoms. A comprehensive diagnosis and evaluation by a healthcare professional is necessary to determine the specific underlying condition and develop an appropriate treatment plan.
Nerve tissue protein
List of MeSH codes (D12.776.641)
Chimerin
Neurodegenerative disease
Surface modification of biomaterials with proteins
Retinylidene protein
Silver proteinate
Becker muscular dystrophy
MYOT
Murine coronavirus
Friedreich's ataxia
Proser1
GJB1
Feed manufacturing
Neurokinin A
Tafamidis
Endoneurium
Galactose
Bone morphogenetic protein 5
Olfactomedin 1
Nerve allograft
Tunicate
Multiple sclerosis
Acquired non-inflammatory myopathy
Rita Levi-Montalcini
Dentate gyrus
Cholesterol
Vsevolod Tkachuk
Structural Classification of Proteins database
Gene therapy of the human retina
Strømme syndrome
Papillary carcinomas of the breast
Multiple system atrophy
Papillary tumors of the pineal region
Metabolism
Esthesioneuroblastoma
Voltage-gated ion channel
CD34
FAM178B
Sodium-potassium pump
List of diseases (C)
COVID-19
Spinal cord
Bilirubin glucuronide
Cell cycle
Histamine H3 receptor
Anthony Mahowald
Lyme disease
Metabotropic glutamate receptor
C286
Integumentary system
Earthworm
Collagen, type IV, alpha 2
Toxin
Waldenström macroglobulinemia
Lepidosauria
Prostate cancer
Physiological effects in space
Telithromycin
Index of biochemistry articles
Nerve Tissue Proteins - Myelin-Oligodendrocyte Glycoprotein | CU Experts | CU Boulder
Host-parasite interaction associated with major mental illness
NIH VideoCast - Polyglutamine-Induced Neurodegeneration: Pathogenesis is Linked to Native Protein Biochemistry Function
Tian Ge, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
NIOSHTIC-2 Search Results - Full View
Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular...
Publication Detail
Human immunodeficiency virus-1/simian immunodeficiency virus infection induces opening of pannexin-1 channels resulting in...
Necrotizing Fasciitis: Practice Essentials, Background, Pathophysiology
Bone marrow biopsy: MedlinePlus Medical Encyclopedia
Leukodystrophy | National Institute of Neurological Disorders and Stroke
Neurotrophin 3 | Profiles RNS
A Cancerous Conversation Fuels Oral Tumors | National Institute of Dental and Craniofacial Research
Sex-specific differences in aging and Alzheimer's disease may be tied to genetics | National Institute on Aging
MeSH Browser
Nexcella Announces Commencement of NXC-201 Engineering Batches at its U.S. CAR-T Manufacturing Site
Axonal Transport of Neurofilaments: A Single Population of Intermittently Moving Polymers | Journal of Neuroscience
RFA-DK-00-014: MOUSE METABOLIC PHENOTYPING CENTERS FOR MODELS OF DIABETES AND ITS COMPLICATIONS
Smithfield BioScience, BioCircuit Technologies to Deliver Innovative Nerve Repair Solution
Nexcella Announces Commencement of NXC-201 Engineering Batches at its U.S. CAR-T Manufacturing Site
Asparagine Market Size, Industry Share & Trends - 2032
TPP1 gene: MedlinePlus Genetics
Quantitative proteomic analysis of the central amygdala in neuropathic pain model rats. - International Association for the...
10 Controversial Theories Supported By Compelling Evidence - Listverse
Amyloid Hypothesis For Alzheimer's In Doubt After Lilly's Drug Failure : Shots - Health News : NPR
Bone marrow derived stem cells facilitate axonal regeneration in a rat model of 2, 5-hexanedione-induced neuropathy via miRNA...
Friday Squid Blogging: Ram's Horn Squid Video - Schneier on Security
Cancer exosomes induce tumor innervation | Nature Communications
Neurofibromatosis Type 1 (NF1) : Overview, Causes, Symptoms, Treatment - illness.com
Publications - Salk Institute for Biological Studies
Infiltrate this cancerous environment early2
Neurons7
- Sensory neurons (a type of nerve cell) in culture that were exposed to p53-deficient oral cancer cells sprouted projections called neurites. (nih.gov)
- These microRNAs nudge sensory neurons to reduce their normal gene activity and adopt genetic characteristics of a different class of nerve cells, known as adrenergic neurons, that are usually rare in the oral cavity. (nih.gov)
- To confirm that the adrenergic neurons were promoting tumors, the scientists blunted adrenergic signaling in mice-either by disabling sensory nerves or giving adrenergic-blocking drugs. (nih.gov)
- Nerve injury-induced protein (Ninjurin)-1 is a cell adhesion molecule that is upregulated in neurons and Schwann cells after transection injury in rats. (koreamed.org)
- Once being damaged, the peripheral nerves, formed by axons of terminally differentiated neurons and glial cells, are well-known to process with a slow and limited recovery and serious damage may result in permanent debilitation or disability. (researchsquare.com)
- Microtubule-associated proteins that are mainly expressed in neurons. (uchicago.edu)
- Ever since Dr. George G. Glenner's 1984 discovery that amyloid is the main component of the plaques that riddle the Alzheimer's-afflicted brain, it has been assumed that the protein somehow contributes to the disorder - that it jams up cellular machinery, rendering neurons unable to effectively communicate, to form new memories, to remember where the keys are. (npr.org)
Abnormal5
- Alexander disease-a disorder characterized by the destruction of white matter and the formation of abnormal clumps of protein called Rosenthal fibers that accumulate in astrocytes in the brain. (nih.gov)
- Hamartoma is composed by an excessive growth of mature tissue present in wrong proportions and abnormal arrangements. (koreamed.org)
- Onpattro is a medicine used to treat nerve damage caused by hereditary transthyretin (hATTR) amyloidosis, a disease in which abnormal proteins called amyloids build up in tissues around the body including around the nerves. (europa.eu)
- Alzheimer Disease Alzheimer disease is a progressive loss of mental function, characterized by degeneration of brain tissue, including loss of nerve cells, the accumulation of an abnormal protein called beta-amyloid. (merckmanuals.com)
- These abnormal antibodies can't be broken down, so they build up in tissue, nerves and organs. (usahealthsystem.com)
Organs6
- The broken protein forms amyloid deposits in tissues and organs around the body, including around nerves, where it interferes with their normal functions. (europa.eu)
- By harvesting porcine bioproducts for medical applications - such as organs, mucosa, and tissues - we have the ability to improve lives through the development of innovative pharmaceuticals and medical devices like this one. (prnewswire.com)
- NIH-funded scientists organ, if it can perform the are exploring innovative ways to right job and functions, it fix faulty organs and tissues or may not need to look like even grow new ones. (nih.gov)
- One research team guided out tissues and organs with living, human stem cells to become working parts. (nih.gov)
- Other scientists are using different working animal kidneys, livers, hearts, to restore a damaged organ or tissue, 3-D bioprinting technologies--some lungs, and other organs. (nih.gov)
- The decellularization technique ease or injury or something else," says ate new tissues or organs," Lundberg was used by Dr. Martin Yarmush and Dr. Martha Lundberg, an NIH expert says. (nih.gov)
Connective tissues2
- A normal result means the bone marrow contains the proper number and types of blood-forming (hematopoietic) cells, fat cells, and connective tissues. (medlineplus.gov)
- Our results indicate that performance of a high rate, low force (HRLF) task regimen results in injury, inflammation and fibrosis in bone, muscles, tendons, nerves and associated loose connective tissues. (cdc.gov)
Discovered a new role for nerves1
- Scientists discovered a new role for nerves in oral cancer progression, in which tumor cells send genetic messages that transform nerves into cancer-promoting agents. (nih.gov)
Cytosolic proteins2
- Finally, we show that the apparent existence of a stationary neurofilament network in mouse optic nerve is most likely an experimental artifact due to contamination of the neurofilament transport kinetics with cytosolic proteins that move at faster rates. (jneurosci.org)
- We identified more than 50 cytosolic proteins as significantly altered in their expressions in CeA of SNT rats, and most of these changes have been validated at mRNA levels by qRT-PCR. (iasp-pain.org)
Peptides3
- Tripeptidyl peptidase 1 acts as a peptidase, which means that it breaks down protein fragments, known as peptides, into their individual building blocks (amino acids). (nih.gov)
- CLN2 disease is characterized by the accumulation of proteins or peptides and other substances in lysosomes. (nih.gov)
- As a result, it takes longer for peptides and other substances to accumulate in the lysosomes and damage nerve cells. (nih.gov)
Rats4
- Sciatic nerves of HD/HD + BMSCs treated rats, as a representative tissue for peripheral nerve, were analyzed using electron microscopy, immunohistochemistry, western blotting and RNA sequencing. (researchsquare.com)
- We studied the expression levels of proteins in CeA of spinal nerve transection (SNT) model rats. (iasp-pain.org)
- We also identified more than 40 membrane proteins as notably up- or down-regulated in CeA of SNT model rats relative to a control using stable isotope dimethyl labeling nano-LC-MS/MS based proteomics and found that one of such protein, doublecortin, is specifically localized in the membrane fraction without changes in total amount of the protein. (iasp-pain.org)
- Immunohistochemistry showed that doublecortin is expressed in processes in CeA of rats 7 and 21 days post SNT surgery, suggesting doublecorin is one of the proteins which may contribute to the plastic changes in CeA in the neuropathic pain model. (iasp-pain.org)
Amyloidosis5
- The latest success of a study attempting to knock out the transthyretin (TTR) protein-the gene encoding the symptom-inducing protein related to transthyretin amyloidosis (ATTR)-has many within the genetics field believing we've entered a new era of breakthroughs in CRISPR research, one where treatment options for even more challenging genetic diseases might be on the horizon. (idtdna.com)
- In patients with hATTR amyloidosis, a protein called transthyretin which circulates in the blood is defective and breaks easily. (europa.eu)
- In one main study involving 225 hATTR amyloidosis patients with stage 1 or 2 nerve damage, Onpattro was shown to be more effective than placebo (a dummy treatment) at slowing down the nerve damage caused by the disease. (europa.eu)
- Over time, amyloidosis damages the tissue and interferes with its function. (usahealthsystem.com)
- Dr. Solomon, who is presently retired, is a worldwide recognized leader in the research about the pathogenesis of light-chain-derived (AL) amyloidosis and other disorders caused by overproduction of monoclonal light chains, also known as Bence Jones Proteins," del Pozo-Yauner said. (usahealthsystem.com)
Cancerous1
- For example, radioactive ions encased in buckyballs have shown promise in targeting cancerous tissue without the associated damage to healthy tissue. (listverse.com)
Amyloids1
- In AL patients, plasma cells in the bone marrow produce misfolded proteins called amyloids. (usahealthsystem.com)
Peripheral nerves1
- BioCircuit is committed to developing medical technologies, such as Nerve Tape ® , to repair, monitor, and control peripheral nerves precisely and reliably. (prnewswire.com)
Fibers5
- White matter is tissue made up of bundles of nerve fibers (axons) that connect nerve cells. (nih.gov)
- The fibers are covered and protected by an insulating layer of proteins and fatty materials (lipids) called myelin. (nih.gov)
- The pulp is extensively supplied with nerve fibers, a rich blood supply, and is surrounded by dentin making it an important model for the study of pain, inflammation, and the movement of fluids, bacteria, or their products through the dentinal tubules. (nih.gov)
- In both mice and humans, adrenergic nerve fibers were denser in p53-deficient oral tumor tissue. (nih.gov)
- In order to counteract this, a new therapy concept is being established: An in situ malleable, resorbable hydrogel is to serve regenerating nerve fibers as a growth matrix. (nmi.de)
Mutations5
- Heterozygous loss-of-function mutations in the X-linked gene CASK are associated with mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH) and ophthalmological disorders including optic nerve atrophy (ONA) and optic nerve hypoplasia (ONH). (nih.gov)
- Mutations in any of these genes can affect how the lipid or protein works and can interrupt the normal formation, processing, and development of myelin and the function of white matter. (nih.gov)
- The disorder is caused by mutations in the LMNB1 gene which is responsible for making lamin B1 protein. (nih.gov)
- The team found that high nerve density and TP53 mutations in oral cancer tissue were associated with earlier death. (nih.gov)
- The scientists began by analyzing patient data and found that TP53 mutations and high nerve density in oral cancer tissue were associated with earlier death. (nih.gov)
Mice5
- The researchers found that in mouse models of oral cancer, animals lacking p53 had denser nerve networks around their tumors compared to control mice with p53. (nih.gov)
- To induce autoimmune uveitis in mice, they gave the mice injections of a retinal protein that appears to agitate immune cells in people with the condition. (nih.gov)
- These mice developed damage to the uvea, retina, and optic nerve. (nih.gov)
- Diabetic mice displayed significantly reduced intraepidermal nerve fiber density and sudomotor function. (omeka.net)
- Both high and low dose diabetic mice displayed significantly less axonal regeneration in the sciatic nerve, when measured in vivo, 48h after crush injury. (omeka.net)
Body's3
- Signals from adrenergic nerves trigger the body's "fight-or-flight" response. (nih.gov)
- Adrenergic nerves can trigger the body's "fight-or-flight" response by releasing stimulating chemical messengers. (nih.gov)
- Uveitis can be triggered by eye infections or by autoimmunity, a process in which an overly aggressive response by the immune system results in damage to the body's own tissues. (nih.gov)
Optic nerve8
- Studies on mouse optic nerve have led to the controversial proposal that only a small proportion of neurofilaments are transported in axons and that the majority are deposited into a persistently stationary and extensively cross-linked cytoskeletal network that remains fixed in place for months without movement. (jneurosci.org)
- We show that the transport kinetics and distribution of neurofilaments in mouse optic nerve can all be explained fully by a "stop-and-go" model of neurofilament transport, in which axons contain a single population of neurofilaments that all move stochastically in a rapid, intermittent, and bidirectional manner. (jneurosci.org)
- Importantly, we find that the transport kinetics are not consistent with deposition of neurofilaments into a persistently stationary phase, and that deposition models cannot account for the observed distribution of neurofilaments along mouse optic nerve axons. (jneurosci.org)
- Thus, there is no evidence for the deposition of axonally transported neurofilaments into a persistently stationary neurofilament network in optic nerve axons. (jneurosci.org)
- who analyzed neurofilament transport in mouse optic nerve in a different way and saw no evidence for a stationary cytoskeleton. (jneurosci.org)
- Here, we use computational modeling to reexamine the data of Nixon and colleagues on the mechanism neurofilament transport in mouse optic nerve. (jneurosci.org)
- They can damage not only the uvea, but also the retina and the optic nerve. (nih.gov)
- The retina is the light-sensitive tissue at the back of the eye, and the optic nerve connects the retina to the brain. (nih.gov)
Tumor growth2
Crosstalk2
- Targeting this nerve-tumor crosstalk could lead to more effective treatments for people with head and neck cancers. (nih.gov)
- We wanted to understand the reciprocal tumor-nerve signals that drive cancer progression," says first author Moran Amit, MD, PhD. "This information could help scientists develop the means to target this crosstalk. (nih.gov)
Sciatic1
- Accelerated axon regeneration in sciatic nerves was evidenced by transmission electron microscopy, GAP43 western blotting and MBP/SMI312 immunostaining. (researchsquare.com)
Amyloid protein2
- However, there are numerous treatment options available, including chemotherapy, heart medications, targeted and surgical therapies, and surgical procedures, such as dialysis or transplant to help patients manage and limit the overproduction of amyloid protein. (idtdna.com)
- But the frustration brought by this particular failure could signal a shift in Alzheimer's research - a shift away from targeting accumulations of so-called amyloid protein in the brain, long considered by many in the field to be the crux of Alzheimer's pathology. (npr.org)
Accumulation4
- Five Holstein calves 2-3 months of age accumulation of a protease-resistant form of a normal cel- were intracerebrally injected with 1 mL of 10% (w/v) brain lular prion protein (PrPres) in the central nervous system. (cdc.gov)
- ATTR is marked by an accumulation of misfolded TTR protein in tissues, most significantly those found near nerves and the heart. (idtdna.com)
- Once completed, this process would then prevent the accumulation of TTR protein in blood serum over time. (idtdna.com)
- The hope is that although the body has already built-up high levels of the TTR protein, removal of the TTR gene using CRISPR technology would dramatically reduce additional accumulation, giving the body an opportunity to clear itself of the excess and return to a closer-to-normal state. (idtdna.com)
Substances2
- Myelin, which is whitish in color and makes up much of the white matter in the brain, is a complex substance made up of many different proteins and lipids (fatty substances). (nih.gov)
- Some use a including the pathways for tiny blood in the early stages of testing newly mixture of natural substances called vessels and nerves. (nih.gov)
Neurites2
- Nanotherapeutics, such as oligonucleotide biomaterial Nanoparticles are integrated into the above mentioned implant and will modulate certain cellular processes to a) specifically counteract scarring and b) desensitize growing neurites against growth-inhibiting proteins in adult nerve tissue. (nmi.de)
- The intracellular signalling pathways of neurites are therapeutically modified by the suppression of central proteins. (nmi.de)
Regeneration3
- Nerve regeneration is primarily prevented by gaps in the tissue, scarring and inhibitory proteins. (nmi.de)
- It can be quickly and easily wrapped around two ends of a severed nerve to form a strong, reliable connection with distributed tension to promote regeneration. (prnewswire.com)
- While the mechanism of this neuropathy is not well understood, it is believed to result in part from deficient nerve regeneration. (omeka.net)
Bone5
- Bone marrow is the soft tissue inside bones that helps form blood cells. (medlineplus.gov)
- Increased tendon calcification and a bone mineralization protein in musculoskeletal tissues with repetitive reaching task. (cdc.gov)
- Enhanced expression of this protein would suggest that repetitive and/ or forceful tasks lead to accelerated bone remodeling and tendon matrix changes, which would further our understanding of the etiology of MSDs. (cdc.gov)
- Discussion: Increases in osteoactivin (OA) staining in the periosteum parallels previously reported infl mmatory responses in this same tissue, suggesting that OA may play a role in inflammation- induced bone remodeling by a repetitive reaching and grasping task. (cdc.gov)
- The tooth is a hollow, porous hard tissue embedded in bone, projecting through an epithelial membrane into a septic environment. (nih.gov)
Immunohistochemical1
- Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. (nih.gov)
Cells16
- Myelin provides nutritional support to nerve cells and helps speed up signals between them, allowing them to send and receive messages quickly. (nih.gov)
- Oligodendrocytes and astrocytes belong to a group of cells called glial cells which surround, support, and insulate nerve cells. (nih.gov)
- Effective therapies must target both the tumor and its microenvironment-the supportive network of connective tissue, blood vessels, cells, and molecules that surround the tumor. (nih.gov)
- The scientists found that spherical delivery vehicles called extracellular vesicles were transferring the microRNAs from tumors to nerve cells in the microenvironment. (nih.gov)
- un- provisionally categorized the adrenal gland as nerve tissue like classical BSE, atypical BSE has been detected mainly because of the presence of chromaffi n cells in the medulla in aged cattle and suggested as a possible sporadic form of of the gland. (cdc.gov)
- The tangles involve the twisting of tau protein threads of the nerve cells in the brain tissue. (nih.gov)
- The scientists gathered genetic data from the brain tissue of 508 autopsied individuals via RNA sequencing, a technique used to measure how many copies of specific genes are present in a human's cells at a given time. (nih.gov)
- 1. BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells. (nih.gov)
- That's because existing therapies treat only the tumor itself, and not its microenvironment, the network of connective tissue, blood vessels, cells, and molecules that surround it. (nih.gov)
- Researchers discovered that loss of the tumor-suppressing TP53 gene allows tumor cells to send genetic messages that transform nerves into cancer-promoting agents. (nih.gov)
- Spherical compartments called extracellular vesicles deliver microRNAs to targeted nerve cells, where they can genetically alter cell growth, identity, and other functions. (nih.gov)
- however, nerve cells seem to be particularly vulnerable to their effects. (nih.gov)
- The progressive death of nerve cells in the brain and other tissues leads to the signs and symptoms of CLN2 disease. (nih.gov)
- Asparagine has a significant role in the metabolic control of cell functions in the brain tissues and nerve cells. (futuremarketinsights.com)
- Several clinical stud- desired shapes and then coaxing cells organ's natural structural proteins, ies (involving human volunteers) are to grow within them. (nih.gov)
- Immature cells that have the potential the correct blood vessel patterns, to develop into many different cell nerve connections, and other com- newsinhealth.nih.gov types in the body. (nih.gov)
Adult1
- Onpattro is used in adult patients in the first two stages of the nerve damage (stage 1, when the patient is able to walk unaided, and stage 2, when the patient can still walk but needs help). (europa.eu)
Pathology1
- This has been attributed to a variety of causes, including pulp-dentin pathology, fluid movements through tubules, and excessive nerve excitability. (nih.gov)
Blood vessels1
- Uveitis literally means inflammation of the uvea, which is a middle layer of the eye that includes the iris (the colored ring) and the choroid, a tissue filled with tiny blood vessels. (nih.gov)
Connection between p532
Neuropathic1
- Neuropathic pain resulting from nerve injury can become persistent and difficult to treat but the molecular signaling responsible for its development remains poorly described. (nih.gov)
Pathways1
- Thus, activation of DLK is an early event, or even the master regulator, controlling a wide variety of pathways downstream of nerve injury that ultimately lead to chronic pain. (nih.gov)
Lysosomal1
- 18. Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation. (nih.gov)
Alzheimer's2
- Sometimes, cognitive changes are accompanied by changes in the brain such as the formation of neurofibrillary tangles, a hallmark characteristic of the brain tissue associated with Alzheimer's. (nih.gov)
- Diseased brain tissue from an Alzheimer's patient showing amyloid plaques (in blue) located in the gray matter of the brain. (npr.org)
MeSH1
- tau Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Fatty2
- We hypothesized that chronic leptin treatment, within physiologic limits, would reduce the fatty acid uptake capacity of red and white skeletal muscle due to a reduction in transport protein expression (fatty acid translocase (FAT/CD36) and plasma membrane-associated fatty acid-binding protein (FABPpm)) at the plasma membrane. (mcmaster.ca)
- These studies provide the first evidence that protein-mediated long chain fatty acid transport is subject to long term regulation by leptin. (mcmaster.ca)
Autonomic1
- Autosomal dominant leukodystrophy with autonomic diseases (ADLD)-a rare, slowly progressive disorder characterized by the onset of autonomic dysfunction (dysfunction of the nerves that regulate nonvoluntary body functions, such as heart rate, blood pressure, and sweating), difficulty coordinating movements (ataxia), and mild cognitive impairment. (nih.gov)
Sensory1
- Sensory nerves are highly abundant in the oral cavity and convey touch, texture, and taste. (nih.gov)
Gene3
- Lamin B1 is a structural protein that helps determine the shape of the cell nucleus and plays an important role in cell division and gene expression, including expression of the genes for oligodendrocyte development and production of some myelin proteins. (nih.gov)
- Gene expression is the process by which the instructions in our DNA are converted into a functional product, such as a protein. (nih.gov)
- From NCBI Gene: The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. (nih.gov)
Spinal2
- Furthermore, DLK inhibition also prevents the spinal cord microgliosis that results from nerve injury and arises distant from the injury site. (nih.gov)
- Doctors have long used tissue- may lead to improved treat- engineered skin to heal severe ment for spinal cord injuries, burns or other injuries. (nih.gov)
Muscle1
- In parallel with establishing a commercial supply chain for Nerve Tape ® , BioCircuit is also developing non-invasive, bioelectronic devices able to tap into nerve and muscle activity to provide sensitive, high-resolution monitoring and selective, closed-loop stimulation. (prnewswire.com)
20221
- SMITHFIELD, Va. and ATLANTA , March 16, 2022 /PRNewswire/ -- BioCircuit Technologies , a National Institutes of Health (NIH)-funded medical device company focused on tissue repair and neural interfacing, and Smithfield BioScience , a unit of Smithfield Foods delivering life-saving medical solutions from porcine-derived bioproducts, today announced the companies will produce Nerve Tape ® , a medical device enabling suture-less nerve repair following traumatic injuries. (prnewswire.com)
Degradation1
- Production, degradation, and maintenance of each protein and lipid are controlled by a specific group of genes. (nih.gov)
Brain3
- Canavan disease-a neurological disorder in which the brain degenerates into spongy tissue full of small fluid-filled spaces. (nih.gov)
- It is closely homologous to nerve growth factor beta and BRAIN-DERIVED NEUROTROPHIC FACTOR. (umassmed.edu)
- Overview of Stroke A stroke occurs when an artery to the brain becomes blocked or ruptures, resulting in death of an area of brain tissue due to loss of its blood supply (cerebral infarction) and symptoms that. (merckmanuals.com)
Axonal1
- Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. (uchicago.edu)
Density2
Disorders1
- Work-related musculoskeletal disorders (WMSDs) arise from repeated performance of tasks at submaximal levels of physical exertion that eventually lead to tissue damage due, perhaps, to insufficient recovery of tissues between bouts of performance. (cdc.gov)
Lesion1
- With these biomaterial-based implants we will be able to specifically bridge the lesion site in the nerve tissue. (nmi.de)
Significantly reduced1
- However, in leptin-treated animals plasma membrane fractions of both FAT/CD36 and FABPpm protein expression were significantly reduced in red (-28 and -34%, respectively) and white (-44 and -56%, respectively) muscles (p (mcmaster.ca)
Binds1
- 14. Leucine zipper transcription factor-like 1 binds adaptor protein complex-1 and 2 and participates in trafficking of transferrin receptor 1. (nih.gov)
Play a role1
- Recent evidence suggests nerves play a role in cancer development and progression, and that they could be targets for new therapies. (nih.gov)