Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
A neoplastic disease in which the alveoli and distal bronchi are filled with mucus and mucus-secreting columnar epithelial cells. It is characterized by abundant, extremely tenacious sputum, chills, fever, cough, dyspnea, and pleuritic pain. (Stedman, 25th ed)
Tumors or cancer of the SKIN.
Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.
Rare autosomal dominant syndrome characterized by mesenchymal and epithelial neoplasms at multiple sites. MUTATION of the p53 tumor suppressor gene, a component of the DNA DAMAGE response pathway, apparently predisposes family members who inherit it to develop certain cancers. The spectrum of cancers in the syndrome was shown to include, in addition to BREAST CANCER and soft tissue sarcomas (SARCOMA); BRAIN TUMORS; OSTEOSARCOMA; LEUKEMIA; and ADRENOCORTICAL CARCINOMA.
An intraductal carcinoma of the breast extending to involve the nipple and areola, characterized clinically by eczema-like inflammatory skin changes and histologically by infiltration of the dermis by malignant cells (Paget's cells). (Dorland, 27th ed)
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.
An enzyme that catalyzes the conversion of N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine and water to N-acetyl-beta-D-glucosaminylamine and L-aspartate. It acts only on asparagine-oligosaccharides containing one amino acid, i.e. the ASPARAGINE has free alpha-amino and alpha-carboxyl groups. (From Enzyme Nomenclature, 1992)
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Tumor suppressor genes located on human chromosome 9 in the region 9p21. This gene is either deleted or mutated in a wide range of malignancies. (From Segen, Current Med Talk, 1995) Two alternatively spliced gene products are encoded by p16: CYCLIN-DEPENDENT KINASE INHIBITOR P16 and TUMOR SUPPRESSOR PROTEIN P14ARF.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Tumors or cancer of the human BREAST.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
Tumors or cancer of the COLON.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
Biochemical identification of mutational changes in a nucleotide sequence.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
A malignant epithelial tumor with a glandular organization.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Neoplasms containing cyst-like formations or producing mucin or serum.
The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Elements of limited time intervals, contributing to particular results or situations.
Tumors or cancers of the KIDNEY.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.
An individual's objective and insightful awareness of the feelings and behavior of another person. It should be distinguished from sympathy, which is usually nonobjective and noncritical. It includes caring, which is the demonstration of an awareness of and a concern for the good of others. (From Bioethics Thesaurus, 1992)
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Medical complexes consisting of medical school, hospitals, clinics, libraries, administrative facilities, etc.
The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.
Postmortem examination of the body.
Refers to the whole process of grieving and mourning and is associated with a deep sense of loss and sadness.
Physicians appointed to investigate all cases of sudden or violent death.
The application of pathology to questions of law.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.

Merkel cell carcinoma and melanoma: etiological similarities and differences. (1/1469)

Merkel cell carcinoma (MCC) of the skin and cutaneous malignant melanoma can now be compared epidemiologically through the use of population-based data not previously available for MCC. The results may provide new clues to etiology. In this study, United States data covered by the Surveillance, Epidemiology, and End Results (SEER) Program were from nine areas of the United States (approximately 10% of the population). In 1986-1994, 425 cases of MCC were registered. The annual age-adjusted incidence per 100,000 of MCC was 0.23 for whites and 0.01 for blacks; among whites, the ratio of melanoma to MCC was approximately 65 to 1. Only 5% of MCC occurred before age 50, unlike the lifelong risk of nodular and superficial spreading melanoma. Regional incidence rates of both cancers increased similarly with increasing sun exposure as measured by the UVB solar index. The most sun-exposed anatomical site, the face, was the location of 36% of MCC but only 14% of melanoma. Both cancers increased in frequency and aggressiveness after immunosuppression and organ transplantation (36 cases from the Cincinnati Transplant Tumor registry and 12 from published case reports) and after B-cell neoplasia (5 cases in this study; 13 from case series in the literature). The SEER data contained reports of six patients with both types of cancer; 5 melanomas before the diagnosis of MCC and 1 after diagnosis. MCC and melanoma are similarly related to sun exposure and immunosuppression, but they differ markedly from one another in their distributions by age, race, and anatomical site, especially the face.  (+info)

The elevated serum alkaline phosphatase--the chase that led to two endocrinopathies and one possible unifying diagnosis. (2/1469)

A 39-year-old Chinese man with hypertension being evaluated for elevated serum alkaline phosphatase (SAP) levels was found to have an incidental right adrenal mass. The radiological features were characteristic of a large adrenal myelolipoma. This mass was resected and the diagnosis confirmed pathologically. His blood pressure normalised after removal of the myelolipoma, suggesting that the frequently observed association between myelolipomas and hypertension may not be entirely coincidental. Persistent elevation of the SAP levels and the discovery of hypercalcaemia after surgery led to further investigations which confirmed primary hyperparathyroidism due to a parathyroid adenoma. The patient's serum biochemistry normalised after removal of the adenoma. The association of adrenal myelolipoma with primary hyperparathyroidism has been reported in the literature only once previously. Although unconfirmed by genetic studies this association may possibly represent an unusual variation of the multiple endocrine neoplasia type 1 syndrome.  (+info)

A case of long-term survival with stage IV small cell lung cancer and early-stage central-type squamous cell lung cancer treated by photodynamic therapy. (3/1469)

The present report is on a 67-year-old man with stage IV small cell lung cancer and early-stage centrally located squamous cell cancer of the lung. He was diagnosed as small cell lung cancer with multiple metastasis to the ipsilateral lung and was found to have a central-type early-stage squamous cell cancer by bronchoscope. After obtaining a complete response to the small cell lung cancer with chemotherapy and radiotherapy, photodynamic therapy was applied to the squamous cell carcinoma, resulting in complete disappearance of the tumor. Recurrence of small cell cancer occurred at the ipsilateral lung and this patient died of small cell cancer 8 years after initiation of treatment. Post mortem examination confirmed complete disappearance of squamous cell cancer treated by photodynamic therapy. This is a rare case of long-term survival with stage IV small cell lung cancer and early-stage central-type squamous cell lung cancer successfully treated by photodynamic therapy.  (+info)

p53 and p16INK4A mutations during the progression of glomus tumor. (4/1469)

Glomus tumors are significantly rare tumors of carotid body. The great majority of these tumors are benign in character. Here we present two brothers with hereditary glomus jugulare tumor who had consanguineous parents. Radiotherapy was applied approximately 8 and 10 years ago for treatment in both cases. Eight years later, one of these cases came to our notice due to relapse. The mutation pattern of p53, p57KIP2, p16INK4A and p15NK4B genes which have roles in the cell cycle, was analyzed in tumor samples obtained from the two affected cases in the initial phase and from one of these cases at relapse. The DNA sample obtained from the case in initial diagnosis phase revealed no p53, p57KIP2, p16INK4A or p15INK4B mutation. He is still in remission phase. Despite the lack of p53, p57KIP2, p16INK4A and p15INK4B mutation at initial diagnosis the tumor DNA of the other case in relapse revealed p53 codon 243 (ATG-->ATC; met-->ile) and p16 codon 97 (GAC-->AAC; asp-->asn) missense point mutations. No loss of heterozygosity in p53 and p16INK4A was observed by microsatellite analysis of tumoral tissues in these cases. P53 and p16INK4A mutations observed in relapse phase were in conserved regions of both genes. No previous reports have been published with these mutations in glomus tumor during progression. The mutation observed in this case may due to radiotherapy. In spite of this possibility, the missense point mutations in conserved region of p53 and p16INK4A genes may indicate the role of p53 and p16INK4A in tumor progression of glomus tumors.  (+info)

Primary endometrioid carcinoma of fallopian tube. Clinicomorphologic study. (5/1469)

Twenty cases of primary Fallopian tube endometrioid carcinoma (PFTEC) are presented in the paper. This accounts for 42.5% of all histologic forms of primary Fallopian tube carcinoma (PFTC) found in our Department. The youngest patient was 38, and the oldest 68 years (mean: 56 years). Seven patients were nulliparas. Only two cases were bilateral. According to FIGO staging, 13 cases were evaluated as stage I, 4 as II, and 3 as stage III. Due to the histologic grading, 8 tumors were classified as well, 7 as moderately, and 5 as poorly differentiated. In the time of preparation of the manuscript, 12 women were still alive, 2 of them with recurrent disease. The follow-up of patients without recurrence ranged from 4 to 120 months (median: 63). Eight patients had died (survival time: from 4 to 65 months; median: 26). Metastases were found in 8 patients, especially to ovaries. In 14/20 cases of PFTEC various forms of tubal wall invasion were observed. Blood or lymphatic vessels involvement was found in 9 patients. Six of them had died and one is alive with the symptoms of disease. Immunohistochemical detection of the mutant form of p53 protein and oncogene product, c-erbB-2, was studied in 17 cases. Nine patients exhibited simultaneous p53 protein accumulation and c-erbB-2 expression. 2/9 of these patients are alive with recurrent tumors and 4/9 died. Endometrioid carcinoma of the Fallopian tube can be characterized by a tendency to superficial invasion of tubal wall and in a half of the cases by invasion of vessels. The majority of these tumors were diagnosed at an early stage tumors.  (+info)

Epidemiological analysis of site relationships of synchronous and metachronous multiple primary cancers in the National Cancer Center, Japan, 1962-1996. (6/1469)

BACKGROUND: Multiple primary cancer (MPC) has been recognized as a problem commonly encountered in routine medical practice. A study of MPC is necessary not only to provide insights into the etiology of cancer, but also to provide information for effective medical care by clinical oncologists. METHODS: A cohort of 49,751 cancer patients who were admitted to the National Cancer Center Hospital between 1962 and 1996 was used to study the site relationship of MPC. Logistic and Poisson regression analyses using an internal reference group within the cohort were applied for the calculation of the prevalence odds ratio (POR) for site relationships of synchronous MPC and the incidence rate ratio (IRR) for those of metachronous MPC. RESULTS: Three site combinations with elevated risks for both synchronous and metachronous MPCs, eight with elevated risk for synchronous MPC, five with elevated risk for metachronous MPC and six with decreased risk for synchronous MPC were identified with statistical significance. Among them, the increased risk of metachronous stomach cancer following lymphoma and myeoloma (POR = 1.0 and 1.1, P > 0.05; IRR = 2.5, P < 0.05) and the inverse site-correlation of synchronous MPC between [trachea, bronchus and lung] and other sites of the upper aerodigestive tract [lip, oral cavity and pharynx] (POR = 0.5 and 0.3, P < 0.05) and esophagus (POR = 0.7 and 0.3, P < 0.05) have not been reported previously. CONCLUSIONS: Our results suggest that interventions for lymphoma and myeloma might affect the development of subsequent stomach cancer and additional etiological factors other than tobacco smoking are associated with the development of cancer in the upper aerodigestive tract.  (+info)

Discrimination of double primary lung cancer from intrapulmonary metastasis by p53 gene mutation. (7/1469)

When multiple synchronous lung tumours are identified, discrimination of multicentric lung cancers from intrapulmonary metastases by clinical findings is often difficult. We used genetic alterations in p53 gene as a discrimination marker of double primary lung cancers from single lung cancer with intrapulmonary metastasis. Twenty of 861 patients with primary lung cancer who underwent lung resection were selected as subjects because they showed synchronous double solid tumours of the same histological type in the unilateral lung without distant metastases. In addition, they had been diagnosed as lung carcinoma with intrapulmonary metastasis by clinical and histological findings. DNAs were extracted from paraffin-embedded tissue of paired tumours from these 20 patients. Exons 5-9 of the p53 gene were examined for genetic alterations in the tumours by polymerase chain reaction, single-strand conformation polymorphism analysis and subsequent DNA sequencing analysis. Three different patterns in the distribution of p53 mutations in double lung tumours were observed: [A] mutation in only one of the tumours (four cases), [B] different mutations in the tumours (two cases), and [C] same mutation in both tumours (one case). The cases of [A] or [B] patterns could be classified as double primary lung cancers, while the case of the [C] pattern was suggested to be lung cancer with intrapulmonary metastasis. These results suggested that the multicentric cancers were more frequent than the intrapulmonary metastatic cancers in double cancer cases.  (+info)

Mismatch repair gene defects contribute to the genetic basis of double primary cancers of the colorectum and endometrium. (8/1469)

Hereditary non-polyposis colorectal cancer (HNPCC) is a dominantly inherited cancer syndrome caused by germline defects of mismatch repair (MMR) genes. Endometrial cancer is the most common extracolonic neoplasm in HNPCC and is the primary clinical manifestation of the syndrome in some families. The cumulative incidence of endometrial cancer among HNPCC mutation carriers is high, estimated to be from 22 to 43%. We hypothesized that women with double primary cancers of the colorectum and endometrium are likely to be members of HNPCC families. In order to determine how frequently HNPCC manifests in the context of double primary cancers, we examined alterations of two MMR genes, hMSH2 and hMLH1, in 40 unrelated women affected with double primary cancers. These cases were identified using hospital-based and population-based cancer registries in Ontario, Canada. MMR gene mutations were screened by single-strand conformation polymorphism analysis and confirmed by direct sequencing. Eighteen percent (seven of 40) were found to harbor mutations of one of the two MMR genes. Analysis of colorectal and/or endometrial tumors of mutation-negative probands found microsatellite instability in seven of 20 cases. Six of seven mutation-positive probands had strong family histories suggestive of HNPCC. First degree relatives of mutation-positive probands had a very high relative risk (RR) of colorectal cancer (RR = 8.1, CI 3. 5-15.9) and endometrial cancer (RR = 23.8, CI 6.4-61.0). The relative risk of mutation-negative cases was 2.8 (CI 1.7-4.5) for colorectal cancer and 5.4 (CI 2.0-11.7) for endometrial cancer. We recommend that all double primary patients with cancers at these sites should have a genetic evaluation, including molecular analysis for HNPCC where appropriate.  (+info)

TY - JOUR. T1 - Multiple primary cancers in patients with gastric cancer. AU - Wu, Chew Wun. AU - Lo, Su Shun. AU - Chen, Jen Hao. AU - Hsieh, Mao-Chih. AU - Li, Anna F.Y.. AU - Lui, Wing Yiu. PY - 2006/5/1. Y1 - 2006/5/1. N2 - Background/Aims: Some gastric cancer patients have multiple primary cancers (MPC). We evaluate the current status of MPC with gastric cancer. Methodology: 2,109 gastric cancer patients treated between 1987 and 2002 were analyzed. Results: There were 99 MPC with gastric cancer (4.7%). Second cancer (77.8%) was discovered within 5 years before and after the onset of gastric cancer. 34.3% of patients were discovered within 1 year (synchronous tumor). In the 77 male patients, prostate cancer was the most common occurrence (19.5%), followed by cancers of the colon (18.2%) and liver (14.3%). In the 22 female patients, colon cancer was the most common (31.9%) followed by breast and cervix cancers (22.7%). These cancers were the most common diseases in Taiwan in the same period. ...
Epidemiologic studies of various incidence patterns of multiple primary cancer in patients with cancer have guided research about carcinogenic mechanisms that may apply to several organ sites [1, 2]. At issue is whether risk patterns exist that predict subsequent primary cancer in patients with an index primary cancer of a particular organ and type. Also at issue is whether apparent increases in risk result from 1) shared or common etiologic factors in the pathogenesis of the index and second primary cases of cancer; 2) adverse toxic effects of agents used in the treatment of the index cancer; 3) random or chance effects [for example, those occurring after multiple significance testing]; or 4) spurious associations that are the result of confounding by correlated lifestyle risk factors or by biased ascertainment of new primary cancer as a result of more careful medical surveillance in patients with a history of cancer. The application of criteria for judging the biological plausibility of a ...
A 50 year old female admitted to R L jalappa Hospital, kolar, presented with synchronous primary tumours of the thyroid and breast. Pathological examination of a tissue sample following biopsy identified papillary carcinoma of the thyroid and invasive ductal carcinoma of the breast to provide a definitive diagnosis of synchronous primary tumors. The patient was healthy prior to diagnosis and the family history was non contributory. Upon admission, the size of the primary tumour biopsied, pathological diagnosis was an invasive carcinoma of the breast. A tumor measuring 3.0x2.5x2.0 cm was identified in the right side of the thyroid lobe, however, no further abnormalities were identified. Preoperative imaging included an ultrasound of the neck, which revealed a hypoechoic heterogeneity in the right lobe of the thyroid (size, 3.2x1.5 cm) exhibiting punc¬tate calcification. The patient was negative for clinical neck lymph node metastasis. A general physical examination did not indicate any ...
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Malignant neoplasm of pericardium|Malignant tumor of endocardium|Malignant tumor of endocardium (disorder)|Malignant tumor of heart|Malignant tumor of heart (disorder)|Malignant tumor of myocardium|Malignant tumor of myocardium (disorder)|Malignant tumour of endocardium|Malignant tumour of heart|Malignant tumour of myocardium|Primary malignant neoplasm of endocardium|Primary malignant neoplasm of endocardium (disorder)|Primary malignant neoplasm of epicardium|Primary malignant neoplasm of epicardium (disorder)|Primary malignant neoplasm of heart|Primary malignant neoplasm of heart (disorder)|Primary malignant neoplasm of myocardium|Primary malignant neoplasm of myocardium (disorder)|Primary malignant neoplasm of pericardium|Primary malignant neoplasm of pericardium (disorder)
Background: Due to improvements in diagnosis, the better outcomes of oncological patients and the increase in the average age, the incidence of synchronous tumours is likely to increase. Aim: To reflect on the challenges of a case with multiple integrated diagnostic and therapeutic approaches and to bring to consideration the increasing prevalence of similar situations. Case Presentation: In this clinical case, the authors describe the evolution of an asymptomatic patient with several synchronous tumours (a GEJ primary adenocarcinoma, a low grade urothelial carcinoma in situ, a localized squamous cell lung carcinoma and 2 IPMNs). Conclusion: The challenge of this case lies in the difficult diagnostic approach, the assembly of a multidisciplinary and time-sensitive treatment plan and the individualized follow-up, due to lack of guidelines. More research is needed in this area.
Multiple primaries [14] are more than one tumour arising in different sites and or of different histology either synchronous or metachronous depends on the duration between them, 2-month according to SEER data [15] and 6 months according to IARC. In our study, we used the definition of IARC. The burden of multiple tumours is expected to increase due to the use of accurate imaging techniques. In a single facility in Saudi Arabia, we collected 54 cases over 7 years. Multiple-Primary did not always signify a bad prognosis as we treated all non-metastatic cases with curative intent.. It is most imperative to diagnose it early before the patient reaches the metastatic stage. This means that we should have a high degree of suspicion. The role of the radiologist is crucial as usually, radiologists are first to flag for suspicion of multiple tumours. In our study, most of the synchronous tumours were detected initially by CT scan then confirmed pathologically. Examples from our study as CT scan done for ...
Data on 50 patients with multiple separate primary carcinomas of the lung are presented. Eighteen had synchronous tumors and 32 had metachronous tumors, the intervals between diagnoses varying from 4 months to 16 years. Histologic patterns in the two different carcinomas were the same in 31 patients …
An increasing number of patients with multiple primary cancers are encountered due to improved cancer detection, widespread cancer screening, and better cancer treatment. Here, we report such a patient without a family history of malignancies or a known genetic predisposition developing three primary malignancies of the rectum, breast, and kidney. A 63-year-old female who underwent an anterior resection for rectal cancer was detected to have an elevated carcinoembryonic antigen (CEA) level during a routine follow-up, 8 years after the initial surgery. Clinical examination revealed a left breast lump which was confirmed as invasive ductal carcinoma (pT3 pN0 cM0). Imaging and colonoscopy excluded a local recurrence. However, a right renal lesion suggestive of a renal cell carcinoma was detected (pT1a). She underwent left mastectomy with a sentinel lymph node biopsy and a right partial nephrectomy with a curative intent. Postoperatively, CEA levels declined to normal limits. Management of multiple primary
The last decade has experienced a steady increase in the incidence of MPM [16]. With the expected survival of oncology patients prolonged, it is no longer rare to observe a subsequent primary malignancy in long-term follow-up, especially those from therapy-related carcinogenesis [17, 18]. A recently published paper provided by the Surveillance, Epidemiology and End Results Program estimated 7.9% of cancer-survivors were living with a history of more than one primary malignancy in the U. S [16]. The reported prevalence estimated that cancer-survivors were at an increased risk of being diagnosed with a secondary primary malignancy [19-21]. Bhatia et al. showed the risk of second tumor was increased approximately 18 times in survivors of childhood Hodgkins lymphoma [21]. The incidence of second neoplasm in cancer-survivors (2.3%, 68/2909) of our center was in accordance with previous literature [6, 16, 22, 23], which was higher than that of the normal population [1]. We hypothesized that the ...
Five hundred and sixty-five cases of large bowel cancer were analysed. There were 8 (1.4%) appendiceal tumours, 296 (52.4%) colonic cancers, 236 (41.8%) rectal cancers, 6 (1.1%) anal cancers and 19 (3.4%) multiple primary cancers of the large bowel. Non-mucinous adenocarcinoma was by far the commonest histological type of large bowel cancer (74.7%). This was followed by mucinous carcinoma (20.7%). Other histological types were relatively uncommon. They included carcinoid tumours (1.8%), signet-ring cell carcinoma (1.5%), squamous cell carcinoma (0.7%), undifferentiated carcinoma (0.4%) and adenosquamous carcinoma (0.2%). The proportion of mucinous carcinoma was greater among the Indians and Malays than among the Chinese. There was a positive correlation between the grade and extent of spread of the tumour. The right colon had greater proportion of poorly differentiated adenocarcinomas than the left colon; this tendency was more evident in females. Mucinous carcinoma tended to occur more ...
Looking for medication to treat primary malignant neoplasm of peritoneum? Find a list of current medications, their possible side effects, dosage, and efficacy when used to treat or reduce the symptoms of primary malignant neoplasm of peritoneum
In an international genetic study (International Sarcoma Kindred Study) reported in The Lancet Oncology, Ballinger et al found that approximately half of all patients with sarcoma harbored potentially pathogenic monogenic and polygenic variation in known and novel cancer genes.. Study Details. The study included 1,162 patients with sarcoma aged ≥ 15 years from 4 cohorts. Targeted exon sequencing using blood (n = 1,114) or saliva (n = 48) was performed for 72 genes selected on the basis of association with increased cancer risk. A case-control rare variant burden analysis included 6,545 white controls from 3 cohorts. Rare variants were classified as known, expected, or predicted.. Excess of Pathogenic Variants. Median age at cancer diagnosis was 46 years in the sarcoma probands. Multiple primary cancers were found in 170 patients (15%), and 155 (17%) of 911 families with informative pedigrees fitted recognizable cancer syndromes. On case-control rare variant burden analysis, 638 (55%) of the ...
TOYOTA Kazuhiro , NAKATSUKA Hirofumi , MATSUGU Yasuhiro , OGAWA Takayuki , OSHIRO Hisashi , NAKAHARA Masahiro , OJIMA Yasutomo 日本臨床外科学会雑誌 = The journal of the Japan Surgical Association 62(8), 1837-1841, 2001-08-25 Ichushi Web References (16) Cited by (10) ...
Synchronous primary cancers are occasionally observed, but TTM is extremely rare; only about 100 cases have been reported in the English literature. Campbell et al. [7] proposed the concept of TTM, which can be distinguished from collision tumor based on following criteria: 1) more than one primary tumor; 2) the recipient tumor may be a true benign or malignant neoplasm; 3) the metastatic neoplasm is a true metastasis with established growth within the host tumor, not the result of contiguous growth (collision tumor) or tumor emboli; 4) primary tumors spreading into the lymphatic system in the setting of generalized lymphoreticular malignancy are excluded.. According to the seed and soil hypothesis [8] of cancer metastasis, interactions between cancer cells (seed) and specific organ microenvironments (soil) determine the outcome of metastasis. Renal cell carcinoma and meningioma are both highly vascularized tumors, and have high lipid and glycogen content, which can provide a fertile ...
A subtype of familial breast cancer that includes colorectal cancer was recognized by Lynch et al. already in 1972 [19] and recently the CHEK2 1100delC mutation was proposed to represent a low-penetrant breast cancer susceptibility allele [10, 11]. This variant has been identified at a particularly high frequency (18%) in families with a hereditary breast- and colorectal cancer phenotype [16]. Since development of multiple primary tumors is a hallmark of hereditary cancer and a high frequency of the CHEK2 1100delC had been described in hereditary breast and colorectal families, we assessed the contribution of this variant to the development of double primary breast and colorectal cancer in a population-based patient material. Among the 75 patients with metachronous tumors of the breast and the colorectum successfully studied, 2 (2.5%) carried the CHEK2 1100delC mutation compared to 1% in the control group [18]. These frequencies were not significantly different (p = 0.26), but the small size of ...
Synchronous composite tumors have been described but are uncommon. Moreover, simultaneous occurrence of synchronous tumors in the same tissue or organ is even less common. We report a case of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma and malignant melanoma (MM) occurring synchronously in the same lymph node. Several cases of an association between cutaneous malignancies and lymphoproliferative disorders have been reported. Some of which included CLL and MM, occurring in the same patient often CLL after MM. The risk of having CLL after MM has been reported to be increased. Various genetic and environmental etiologies have been postulated, but have as yet not been proven. To our knowledge this is the first time that synchronous occurrence of these two malignant processes in the same tissue is described. In this case it is important that the melanoma was recognized in the excised lymph node, as this finding had much more critical treatment and long term survival consequences.
Di Martino E, Sellhaus B, Hausmann R, Minkenberg R, Lohmann M, Esthofen MW.//. Patients who developed metachronous tumours had a five-year survival rate of 68.9 per cent for the index tumours, and a 26 per cent five-year survival rate with the occurrence of a second neoplasm. With synchronous tumours a mean survival time of 18 months and a five-year survival rate of 11.9 per cent was found (p , 0.0001).. The prognosis of synchronous tumours is significantly lower when compared to malignancies of a metachronous nature, despite some encouraging individual results. Only the early implementation of aggressive treatment methods for second primaries is successful in terms of survival.. ...
Ileal neuroendocrine tumors (NETs) represent the most common neoplasm of the small intestine. Although up to 50% of patients with ileal NETs are diagnosed with multifocal disease, the mechanisms by which multifocal ileal NETs arise are not yet understood. In this study, we analyzed genome-wide sequencing data to examine patterns of copy number variation in 40 synchronous primary ileal NETs derived from three patients. Chromosome (chr) 18 loss of heterozygosity (LOH) was the most frequent copy number alteration identified; however, not all primary tumors from the same patient had evidence of this LOH. Our data revealed three distinct patterns of chr18 allelic loss, indicating that primary tumors from the same patient can present different LOH patterns including retention of either parental allele. In conclusion, our results are consistent with the model that multifocal ileal NETs originate independently. In addition, they suggest that there is no specific germline allele on chr18 that is the ...
Ovarian tumours are relatively common, with the majority (approximately 80%) being benign and occurring in women of reproductive age. Malignant tumours occur in older women, most commonly aged 40-65 years, although certain uncommon tumour types do occur at a younger age. Many ovarian tumours - particularly of epithelial type - are bilateral: it is not clear whether these represent synchronous primary tumours or the spread of a single original tumour from one ovary to the other. Most ovarian tumours are non-functional and, in view of their relatively hidden anatomical location, tend to present late, usually as abdominal swelling due to the presence of a mass or associated ascites.. Predisposing factors include nulliparity and gonadal dysgenesis. Recently, it has become clear that ovarian carcinoma runs in some families in association with inherited abnormalities of, for example, the BRCA1 gene. Patients with a strong family history of breast and/or ovarian cancer can now be screened for specific ...
Oral squamous cell carcinoma (OSCC) is an aggressive epithelial malignancy that is the sixth most common neoplasm in the world today. Despite numerous advances in treatment the long-term survival has remained ~55%. This poor long-term survival is due to a number of factors including delayed diagnosis and the development of multiple primary tumors. Therefore, the early detection and prevention of all premalignant lesions is critical for the long-term survival of these patients ...
Researchers have packaged a widely used cancer drug into nanoparticles, more than doubling its effectiveness at destroying tumors. They found significantly
Semantic Scholar extracted view of Squamous cell carcinoma of the liver: metastasis or primary neoplasm? by Silvia Bondini et al.
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A Case Report Describing a Rare Presentation of Simultaneous Occurrence of MPO-ANCA-Associated Vasculitis and Rheumatoid Arthritis. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Lung cancer is the second most common non-skin malignancy. In a PET-CT-based staging of lung cancer, positive metabolic neck avidity may be considered a metastasis; however, other interpretations may be synchronous tumor or non-malignant avidity. We present nine cases of synchronous lung and thyroid cancer, which do not share common characteristics, and whose concurrent detection affects the patients treatment and prognosis. ...
Although some epidemiologic associations for ovarian cancer are established, such as the risk reduction due to parity or oral contraceptive use, the influence of other characteristics like endometriosis and non-steroidal anti-inflammatory use is less clear. Distinguishing categories of ovarian cancer based on shared pathways of development may clarify these associations and further our understanding of the disease. Traditionally, ovarian cancers have been thought to arise from the ovarian surface epithelium. Recent evidence in BRCA1 or 2 mutation carriers showing synchronous tumors in fallopian tubes and potential precursor lesions with p53 signatures that match tumors suggest that some ovarian cancers may originate in the fallopian tube. Tumor origin (e.g., ovarian vs. fallopian) may be classified by rigorous pathologic review protocol, including the identification of tubal lesions and p53 signatures, but this is not practical in population-based studies where the needed tissue is not always ...
Development of resistance is a significant clinical problem for virtually all targeted cancer therapies. We have generated a reproducible, patient derived xenograft (PDX) model of acquired vemurafenib resistance to address these challenges. Continuous treatment of V600E melanoma tumors, caused synchronous tumor stasis for approximately 7 weeks, following which, all tumors displayed simultaneous resistance marked by rapid tumor growth. Additionally, this model maintains the resistance phenotype upon serial transplantation, providing a platform for testing rational drug selection. The fidelity of the PDX models was further confirmed using a BRAF V600V tumor which did not respond to vemurafenib. Onset of vemurafenib resistance is accompanied by increased phosphor-ERK signifying re-engagement of the MAPK signaling pathway and supporting MEK as a potential target. MEK inhibition in vemurafenib resistant tumors using PD0325901, resulted in rapid tumor shrinkage and dramatically reduced phosphor-ERK ...
Background - Endoscopic mucosal resection is one of the most frequent therapeutic alternatives for large colorectal lateral spreading tumors. There are few data on the prevalence of synchronous lesions on these patients. Objective - To describe the prevalence of synchronous colorectal lesions in patients referred for endoscopic mucosal resection of lateral spreading tumors ,20 mm.m.br/wp-admin/post-new.php?classic-editor&post_type=post&source_lang=pt-br&trid=2894&lang=en&admin_bar=1…. ...
Treatment of the primary neoplasm with radiotherapy or chemotherapy is an established risk factor for second neoplasms (SNs) after childhood cancer. As only a small percentage of the treated children suffer from SN, other shared risk factors must be involved. A predisposition for the occurrence of a SN might be a pre-existing somatic genetic defect associated with DNA repair. We investigated the association between gene expression involved in DNA-repair and the development of SNs after childhood cancer. Designed as a feasibility study this project addressed the possibility of obtaining samples for genetic analyses from former patients through the German Childhood Cancer Registry. We recruited 20 patients with two neoplasms (the first occurring in childhood) and 20 matched patients with one neoplasm in childhood. Matching was by first neoplasm, age and year of first diagnosis. Registered SN were confirmed to be no relapses or alternative manifestations of the primary neoplasm. Participants were ...
Brave Tia has suffered a double cancer diagnosis in less than six months - mast cell tumour and lymphoma and is now coping with chemotherapy. Well done Tia.
In cognitive radio networks, the licensed frequency bands of the primary users (PUs) are available to the secondary user (SU) provided that they do not cau
leukemia and lymphoma, primary malignant neoplasms, neoplasms of the digestive organs, pancreas, thyroid gland, secondary and unspecified neoplasms, benign neoplasms, neurodegenerative diseases, ischaemic heart diseases, complications of pregnancy, perinatal diseases, disorders of thyroid gland ...
A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 (overlapping lesion), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned ...
Twenty-three patients (16 male, 7 female), age 67 years (28-80) were operated for 6.5 (1-38) metastases of which the largest was 40 mm (14-130). Six (27.3%) patients had extra-hepatic metastases, 16 (72.7%) synchronous presentation. All patients received chemotherapy, 6 cycles (3-25) preoperatively and 16 (70%) postoperatively. Ten patients (43%) were rescue ALPPS after failed PVO. Severe complications occurred in 13.6% and one (4.5%) patient died within 90 days of surgery. After a median follow-up of 22.5 months from surgery and 33.5 months from diagnosis of liver metastases estimated 2 year overall survival was 59% (from surgery) and 73% (from diagnosis). Liver only recurrences (n = 8), were treated with reresection/ablation (n = 7) while lung recurrences were treated with chemotherapy ...
Assign 9863 for CML in 2008. The 2010 diagnosis is the same histology. Per the Hematopoietic database, chronic and accelerated phase are alternate names. This is the same primary per Rule M2. Blast phase (crisis) is also an alternate name for CML, which makes the 2012 diagnosis the same primary per Rule M2. As you noted, not all histologies have transformations. If a transformation is not listed, rules M8-M13 do not apply. For these types of cases, use M15 and use the multiple primaries calculator. ...
Rat IgG (H&L), 0.1 mg. This secondary antibody is specifically designed for the detection of multiple primary antibodies (polyclonal or monoclonal) of different host species in experiments where cells are simultaneously labeled without unwanted cross
Rabbit IgG (H&L), 0.2 mg. This secondary antibody is specifically designed for the detection of multiple primary antibodies (polyclonal or monoclonal) of different host species in experiments where cells are simultaneously labeled without unwanted cross
J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20 ...
Introduction. Renal cell carcinoma is one of the top 10 most common cancers in United States and its incidence has been on the rise since the 1990s with an estimated 63,000 new cases in 2016. Other urogenital malignancies, such as penile cancer, are less common in the United States with an annual incidence of 2000 cases.1 Synchronous primary malignancies of the urogenital tract have become increasingly recognized though they are only found as case reports. We describe a patient who initially presented with a large left inguinal mass, and through a series of diagnostic imaging and biopsies, he was found to have 2 separate primary malignancies: right clear cell renal cell carcinoma (RCC) and penile squamous cell carcinoma (PSCC) with metastasis to the left inguinal lymph node. We hope to raise awareness of multiple synchronous primary tumors when present with a urogenital malignancy, diagnostic modalities, and the challenge to treatment.. Case. An 86-year-old male, who had not seen a physician for ...
TP53Z : Li-Fraumeni syndrome (LFS) is a rare autosomal dominant hereditary cancer syndrome associated with germline mutations in the TP53 (also p53) gene. LFS is predominantly characterized by sarcoma (osteogenic, chrondrosarcoma, rhabdomyosarcoma), young-onset breast cancer, brain cancer (glioblastoma), hematopoietic malignancies, and adrenocortical carcinoma in affected individuals. LFS is highly penetrant; the risk for developing an invasive cancer is 50% by age 30 and 90% by age 70 with many individuals developing multiple primary cancers. Childhood cancers are also frequently observed and typically include soft-tissue sarcomas, adrenocortical tumors, and brain cancer. Other reported malignancies include melanoma, Wilms tumor, kidney tumors, gonadal germ cell tumor, pancreatic cancer, gastric cancer, choroid plexus cancer, colorectal cancer, prostate cancer, endometrial cancer, esophageal cancer, lung cancer, ovarian cancer, and thyroid cancer.   There are published criteria for the use in
Actinic keratosis (AK) affects millions of people worldwide, and its prevalence continues to increase. AK lesions are caused by chronic ultraviolet radiation exposure, and the presence of two or more AK lesions along with photodamage should raise the consideration of a diagnosis of field cancerization. Effective treatment of individual lesions as well as field cancerization is essential for good long-term outcomes. The Swiss Registry of Actinic Keratosis Treatment (REAKT) Working Group has developed clinical practice guidelines for the treatment of field cancerization in patients who present with AK. These guidelines are intended to serve as a resource for physicians as to the most appropriate treatment and management of AK and field cancerization based on current evidence and the combined practical experience of the authors. Treatment of AK and field cancerization should be driven by consideration of relevant patient, disease, and treatment factors, and appropriate treatment decisions will ...
Glyphosate - the main ingredient in Monsantos widely used herbicide Roundup - is a colorless, odorless chemical and might seem innocuous to those who spray it on crops. But in the past few months the truth has come out: This chemical can be dangerous to farmers who are exposed to it and to people living close to farming areas.
TY - JOUR. T1 - A case report of multiple primary prostate tumors with differential drug sensitivity. AU - Wilkinson, Scott. AU - Harmon, Stephanie A.. AU - Terrigino, Nicholas T.. AU - Karzai, Fatima. AU - Pinto, Peter A.. AU - Madan, Ravi A.. AU - VanderWeele, David J.. AU - Lake, Ross. AU - Atway, Rayann. AU - Bright, John R.. AU - Carrabba, Nicole V.. AU - Trostel, Shana Y.. AU - Lis, Rosina T.. AU - Chun, Guinevere. AU - Gulley, James L.. AU - Merino, Maria J.. AU - Choyke, Peter L.. AU - Ye, Huihui. AU - Dahut, William L.. AU - Turkbey, Baris. AU - Sowalsky, Adam G.. PY - 2020/12/1. Y1 - 2020/12/1. N2 - Localized prostate cancers are genetically variable and frequently multifocal, comprising spatially distinct regions with multiple independently-evolving clones. To date there is no understanding of whether this variability can influence management decisions for patients with prostate tumors. Here, we present a single case from a clinical trial of neoadjuvant intense androgen deprivation ...
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[INTRODUCTION - Synchronous colorectal cancers are not uncommon, therefore, total colonoscopy is indicated even in cases of distally located large bowel carcinomas. CASE REPORT - An 84-year-old man had emergency surgery because of bowel obstruction and a node-negative carcinoma of the sigmoid colon was removed according to Hartmann. Before the reconstruction of bowel continuity, colonoscopy revealed a relatively small polypoid tumour in the right colon, unsuitable for colonoscopic polypectomy. Two localization clips were then inserted at the site of the endoscopic biopsy that later resulted in the diagnosis of adenocarcinoma. At the time of the reconstruction surgery, an appendectomy was also performed and, though the clips were not found, the polypoid tumour was removed through appendectomic orifice. The polyp thus removed, however, proved to be an adenoma. A repeated colonoscopy and biopsy confirmed both the localization clips and the malignant nature of the remaining right-sided lesion, which was
Using the hydroxylamine-osmium tetroxide (HOT) technique, we have identified a constitutional point mutation in the retinoblastoma susceptibility gene (RB1) which segregates with the expression of retinoblastoma in five affected family members. One member developed a second primary tumor, a small-ce …
UCLA scientists have developed a NanoVelcro Chip that can detect and isolate single cancer cells from patient blood samples for analysis.. Researchers at UCLA report that they have refined a method they previously developed for capturing and analyzing cancer cells that break away from patients tumors and circulate in the blood. With the improvements to their device, which uses a Velcro-like nanoscale technology, they can now detect and isolate single cancer cells from patient blood samples for analysis.. Circulating tumor cells, or CTCs, play a crucial role in cancer metastasis, spreading from tumors to other parts of the body, where they form new tumors. When these cells are isolated from the blood early on, they can provide doctors with critical information about the type of cancer a patient has, the characteristics of the individual cancer and the potential progression of the disease. Doctors can also tell from these cells how to tailor a personalized treatment to a specific patient.. In ...
Relay For Life is an amazing sight of colour, excitement and passion as thousands of people, take on the challenge of keeping their teams baton, and symbol of hope, moving around the track for 19 hours.. Mr Petersen began his Relay journey as a volunteer in 2004 after his best friend and Gramps ultimately lost his cancer battle.. His passion to continue his Grandfathers fight encouraged him to move into the volunteer Entertainment Coordinator role after starting as main stage MC.. After getting a taste of the magic that is Relay, Andrew decided to leave his job and apply for a full time role at Cancer Council SA.. The Project Officer role works closely with local communities to empower them to run their own Relay For Life events.. I do it for Gramps and the whole cancer community, Andrew said.. Gramps was a double cancer survivor, prostate and lymphoma. It was very hard for him and Nanna but he soldiered on like a trooper.. Andrew explains the fire he has for working towards the common ...
Historical Staging and Coding Manuals. Appendix C brings together the site-specific instructions needed to abstract a case, facilitating efficiency and accuracy. The site-specific coding modules include SEER Coding Guidelines; Equivalent Terms, Definitions, Tables, Charts and Illustrations; Multiple Primary Rules; Histology Coding Rules; Collaborative Stage Coding Instructions1 and Surgery of Primary Site codes2.. General instructions in the main manual are applicable in the absence of site-specific instructions. All modules include the collaborative stage and surgery codes, and multiple primary and histology coding rules. Some modules include site-specific coding guidelines. The goal is to have stand-alone modules for major anatomic sites.. ...
Multiple myeloma is the most common primary malignant neoplasm of the skeletal system. The disease is a malignancy of plasma cells.
Background This study evaluates the surgical morbidity and long-term outcome of colorectal cancer surgery within an unselected band of patients treated over the time 1994C2003. of HNPCC (1%). Merging all tumours, there have been 186 malignancies (20.6%) thought as UICC stage I, 235 (26.1%) stage II, 270 (29.9%) stage III and 187 (20.6%) stage IV situations. Twenty-four (2.7%) situations were of undetermined stage. Postoperative problems happened in 38% of the full total group (37.8% of CC cases, 37.2% from the RC group, 66.7% from the synchronous cancer sufferers and 50% of these with HNPCC, p = 0.19) Mortality rate was 0.8%, (1.3% CORO1A for cancer of the colon, 0% for rectal malignancy; p = 0.023). Multivisceral resection was performed in 14.3% of cases. Disease-free success in situations resected for treatment was 73% at 5-years and 72% at 8 years. The 5- and 8-calendar year overall survival prices had been 71% and 61% respectively (total situations). At 5-calendar Ketanserin (Vulketan Gel) ...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011 ...
This document describes, among other things, systems and methods for characterizing a tachyarrhythmia. A method comprises obtaining a current first primary characterization of the tachyarrhythmia and a current first primary confidence level of the current first primary characterization, obtaining a current second primary characterization of the tachyarrhythmia and a current second primary confidence level of the current second primary characterization, and determining a current secondary characterization using the current first primary characterization, the current first primary confidence level, the current second primary characterization, and the current second primary confidence level.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. . ...
I had sequenced the N terminus of gp96 from two antigenically distinct tumors, and the sequences were the same. I had generated a polyclonal rabbit serum against the protein in a rabbit called ADAM, and the antiserum detected an identical-sized protein in all tumors and every tissue. In spite of this uniformity, the protein from each tumor elicited immunity only against the tumor from which it was isolated. Gp96 from normal tissues did not elicit tumor immunity against any tumor tested. These findings exhilarated me. I thought that I may have identified a polymorphic gene, perhaps like the MHC or the immunoglobulin family, which was rearranged in tumors and might be responsible for the individually distinct antigenicity of chemically induced mouse sarcomas. After extensive efforts at cloning and sequencing the gp96 cDNA (with the help of Yao-Tseng Chen) (7), and doing intensive Southern blots of genomic DNA from normal tissues and many tumors, there was no hint of polymorphisms or ...
primary cancers and metastatic lesions News from Send2Press Newswire | Press Releases issued by Send2Press related to primary cancers and metastatic lesions
... histiocytic neoplasm which arises in multiple sites simultaneously. Most lesions previously defined as MH are probably more ... Primary lesions of HS occur in spleen, lymph node, lung, bone marrow, skin and subcutis especially of extremities. Secondary ... Delayed regression of multiple histiocytomas can occur and lesions can persist for up to 10 months. Recently, several cases of ... The presence of multiple histiocytomas is now a well recognized syndrome. However, there is yet another presentation in which ...
These neoplasms also accounted for 73% of the multiple primary cancers occurring in 15 family members. Six of these patients ... Close relatives of a cancer patient are at increased risk of that neoplasm, and perhaps other forms of cancer. The excess site- ... and other neoplasms in young patients. Cancer developed in an autosomal dominant pattern in 151 blood relatives, 119 (79%) of ... and other neoplasms". Science. 250 (4985): 1233-8. Bibcode:1990Sci...250.1233M. doi:10.1126/science.1978757. PMID 1978757. P53 ...
Hisada, M.; Garber, J. E.; Li, F. P.; Fung, C. Y.; Fraumeni, J. F. (1998). "Multiple Primary Cancers in Families With Li- ... Li F.P.; Fraumeni J.F. (October 1969). "Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?". Ann. ... before age 56 years or with multiple tumors at any age Multiple tumors (except multiple breast tumors), two of which belong to ... PMID 1978757.CS1 maint: multiple names: authors list (link)[non-primary source needed] Malkin D. & Friend, S.H. (1993). " ...
This occurs through multiple mutations that affect the DNA-mismatch-repair pathways. As a consequence, DNA mutations during ... The malignant growths can either have primary or secondary causes. Adenomatous polyps are considered precursors to cancer and ... Paris classification of colorectal neoplasms. In colonoscopy, colorectal polyps can be classified by NICE (Narrow-band imaging ... Elsevier.CS1 maint: multiple names: authors list (link)[page needed] Finlay A Macrae. "Overview of colon polyps". UpToDate. ...
It also confirms the genetic heterogeneity between the primary neoplasm of breast cancer patients and their respective ... Multiple combinations and genetic modifications are made in such a way that either one or all the genes are put into a ... Metastasis is a process of migration of tumour cells from the primary cancer site to a distant location where the cancer cells ... Many of the genes driving the growth at primary site can determine the dissemination and colonization at the ectopic site. ...
Plasmacytoma, multiple myeloma, Waldenström macroglobulinemia and plasma cell leukemia are malignant neoplasms ("cancer") of ... The T cell-dependent processes are subdivided into primary and secondary responses: a primary response (meaning that the T cell ... Primary amyloidosis (AL) is caused by the deposition of excess immunoglobulin light chains which are secreted from plasma cells ... Multiple myeloma is frequently identified because malignant plasma cells continue producing an antibody, which can be detected ...
In 2016, the WHO revised their classification of myeloproliferative neoplasms to define Prefibrotic primary myelofibrosis as a ... Lacy, MQ; Tefferi, A (April 2011). "Pomalidomide therapy for multiple myeloma and myelofibrosis: an update". Leukemia & ... the primary diagnostic difference being the grade of fibrosis. The primary feature of primary myelofibrosis is bone marrow ... Barosi, Giovanni (2011). "Conventional and Investigational Therapy for Primary Myelofibrosis". Myeloproliferative Neoplasms. pp ...
... origin or other soft tissue neoplasms. The primary method for treatment is surgical, not medical. Radiation and chemotherapy ... Multiple granular cell tumors may seen in the context of LEOPARD syndrome, due to a mutation in the PTPN11 gene. These tumors, ... Feb 2009). "Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11". Clin ... on occasion, may appear similar to neoplasms of renal (relating to the kidneys) ...
While chondrosarcoma is the most common form of a secondary malignant bone neoplasm found in cases of Ollier disease, other ... This provides credence to the theory that multiple genetic mutations are needed to occur in order for Ollier disease to ... Sanger sequencing analysis concluded that exon 4 is the primary location of mutations in IDH1 and IDH2 genes are specifically ... Early detection and consistent and repeated monitoring is important in order to prevent and treat any potential bone neoplasms ...
The neoplasms are often associated with the presence of unerupted teeth, displacement of adjacent teeth and resorption of roots ... Usually presents with multiple large cystic areas. Ameloblastoma with a single cyst cavity account for around 10% of ... Metastasis' look histologically identical to the primary tumour and are benign in nature. The peripheral subtype composes 2% of ... Smaller mandibular neoplasms have been enucleated where the cavity of the tumour is curetted, allowing preservation of the bone ...
In 2016, the WHO revised their classification of myeloproliferative neoplasms to define Prefibrotic primary myelofibrosis as a ... Lacy, MQ; Tefferi, A (April 2011). "Pomalidomide therapy for multiple myeloma and myelofibrosis: an update". Leukemia & ... The primary feature of primary myelofibrosis is bone marrow fibrosis,[3] but it is often accompanied by: *Abdominal fullness ... Barosi, Giovanni (2011). "Conventional and Investigational Therapy for Primary Myelofibrosis". Myeloproliferative Neoplasms. pp ...
CS1 maint: Multiple names: authors list (link) [non-primary source needed]. *^ Eeles, R. (1995). "Germline mutations in the ... Erratum for "Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms"". Science. 259 ( ... Hisada, M.; Garber, J. E.; Li, F. P.; Fung, C. Y.; Fraumeni, J. F. (1998). "Multiple Primary Cancers in Families With Li- ... a proband with multiple tumours (except multiple breast tumours), two of which belong to the LFS tumour spectrum and the first ...
... may refer to: Ruy Lopez chess openings ECO code Malignant neoplasms of independent (primary) multiple sites ICD-10 code ...
... arise as primary neoplasms in lymph nodes of the pancreaticoduodenal region (gastrinoma triangle). Most gastrinomas are ... One fourth of gastrinomas are related to multiple endocrine neoplasia type 1, Zollinger-Ellison syndrome, peptic ulcer disease ... Primary function of gastrin is to induce the release of hydrochloric acid (HCl) from the parietal cells located in the fundus ... Patients with gastrinomas that are also known to be part of neuroendocrine neoplasms must have to deal with two factors related ...
... uncertain whether primary or metastatic site M8000/0 Neoplasm, benign Tumor, benign Unclassified tumor, benign M8000/1 Neoplasm ... NOS M8220/3 Adenocarcinoma in adenomatous polyposis M8221/0 Multiple adenomatous polyps M8221/3 Adenocarcinoma in multiple ... NOS M8000/6 Neoplasm, metastatic Neoplasm, metastatic Tumor, metastatic Tumor, secondary Tumor embolus M8000/9 Neoplasm, ... Lymphomatoid papulosis Primary cutaneous anaplastic large cell lymphoma Primary cutaneous CD30+ large T-cell lymphoma M9719/3 ...
Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell neoplasm ... leukemia Primary central nervous system lymphoma Primary cutaneous follicular lymphoma Primary cutaneous immunocytoma Primary ... Melanoma Merkel cell carcinoma Sarcomas of primary cutaneous origin (e.g. dermatofibrosarcoma protuberans) Lymphomas of primary ... However, some body parts contain multiple types of tissue, so for greater precision, cancers are additionally classified by the ...
Secondary malignant bone tumors are estimated to be 50 to 100 times as common as primary bone cancers. Primary tumors of bone ... Multiple myeloma is a hematologic cancer, originating in the bone marrow, which also frequently presents as one or more bone ... Some benign tumors are not true neoplasms, but rather, represent hamartomas, namely the osteochondroma. The most common ... Rarely, primary bone malignancies such as osteosarcoma may also spread to other bones. Reliable and valid statistics on the ...
Prefibrotic/early primary myelofibrosis Prefibrotic primary myelofibrosis (Pre-PMF) is typically associated with JAK2, CALR, or ... chronic lymphocytic leukemia and multiple myeloma.[citation needed] Genetics is believed to play a central role in the ... In MPNs, the neoplasm (abnormal growth) starts out as benign and can later become malignant. As of 2016, the World Health ... Myeloproliferative neoplasms (MPNs) are a group of rare blood cancers in which excess red blood cells, white blood cells or ...
3) Primary effusion lymphoma, human herpes virus-positive: Also termed primary effusion lymphoma, type I; it is usually ... A lymphoid neoplasm that disseminates widely like the plasma cell lesions in multiple myeloma or is localized like the plasma ... 4) Primary effusion lymphoma, human herpes virus-negative: Also termed primary effusion lymphoma, type II; it is characterized ... Lymphoid neoplasms with plasmablastic differentiation were classified by the World Health Organization, 2017 as a sub-grouping ...
The incidence of mammary desmoid tumors is less than 0.2% of primary breast neoplasms. In Gardner's syndrome, the incidence ... multiple jaw osteomas that give a "cotton-wool" appearance to the jaws, as well as multiple odontomas, congenital hypertrophy ... Nuances in the understanding of genetics have caused some disorders to be split into multiple entities, while others merged ... Gardner syndrome is an autosomal dominant form of polyposis characterized by the presence of multiple polyps in the colon ...
... (GCT) is a neoplasm derived from germ cells. Germ-cell tumors can be cancerous or benign. Germ cells normally ... Extragonadal GCTs were thought initially to be isolated metastases from an undetected primary tumor in a gonad, but many germ ... Others hypothesize a widespread distribution of germ cells to multiple sites during normal embryogenesis, with these cells ... Childhood Extracranial Germ Cell Tumors Extragonadal Germ Cell Tumors Ovarian Germ Cell Tumors Primary Germ Cell Tumors of the ...
Neoplasms and giant aneurysms of the posterior fossa have also been associated with the midbrain syndrome. Vertical ... Women in their 20s-30s with multiple sclerosis Older patients following stroke of the upper brainstem However, any other ... Eyelid retraction (Collier's sign) Conjugate down gaze in the primary position: "setting-sun sign". Neurosurgeons see this sign ...
It houses primary research laboratories dedicated to cancer research, including core facilities for high field NMR, DNA ... The three-story facility houses outpatient space for evaluation and treatment of solid tumor neoplasms including: lung, head ... These innovative teams evaluate and treat the patient's disease, which means that physicians and nurses from multiple ... The second and third floors house inpatient rooms with satellite bases for all primary services and outpatient cancer services ...
The Avian Diagnostic and Oncology Laboratory, in East Lansing, MI is the primary laboratory for research in REV and other tumor ... John Dunn, DVM, MS, PhD (October 2019). "Reticuloendotheliosis in Poultry". Merck Veterinary Manual.CS1 maint: multiple names: ... Reticuloendotheliosis virus represents a third distinct etiological group of avian viral neoplasms, after Marek's disease and ...
Primary cilia play a role in inhibiting the canonical Wnt signaling pathway ( Wnt/β-catenin signaling pathway) by sequestering ... FLCN has multiple phosphorylation sites including serine 62, which are differentially affected by FNIP1 binding and by ... April 2002). "Risk of renal and colonic neoplasms and spontaneous pneumothorax in the Birt-Hogg-Dubé syndrome". Cancer ... November 2010). "Primary cilia regulate mTORC1 activity and cell size through Lkb1". Nature Cell Biology. 12 (11): 1115-22. doi ...
See here for a tabular overview of primary, secondary, in situ, and benign neoplasms. 140 Malignant neoplasm of lip 141 ... malignant neoplasms of lymphoid and histiocytic tissue 203 Multiple myeloma and immunoproliferative neoplasms 203.0 Multiple ... benign neoplasm of uterus 220 Benign neoplasm of ovary 221 Benign neoplasm of other female genital organs 222 Benign neoplasm ... neoplasm of major salivary glands 143 Malignant neoplasm of gum 144 Malignant neoplasm of floor of mouth 145 Malignant neoplasm ...
Multiple genes have been identified for the β-keratins in feathers, and this is probably characteristic of all keratins. The ... Furthermore, the precise expression-pattern of keratin subtypes allows prediction of the origin of the primary tumor when ... Tumors that express keratin include carcinomas, thymomas, sarcomas and trophoblastic neoplasms. ... By analysis of the primary structures of these keratins and other intermediate filament proteins, Hanukoglu and Fuchs suggested ...
... folliculitis Primary cutaneous aspergillosis Primary cutaneous coccidioidomycosis Primary cutaneous histoplasmosis Primary ... Multiple endocrine neoplasia type 3 (mucosal neuromata with endocrine tumors, multiple endocrine neoplasia type 2B, multiple ... neoplasms, and cysts are skin lesions that develop from the epidermal layer of the skin. Aberrant basal cell carcinoma ... Multiple keratoacanthomas (Ferguson-Smith syndrome, Ferguson-Smith type of multiple self-healing keratoacanthomas, multiple ...
... which is linked to increased resistance to chemotherapy and radiation therapy It is a specific antigen on multiple myeloma ... "Predictive value of syndecan-1 expression for the response to neoadjuvant chemotherapy of primary breast cancer". Anticancer ... a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms". American Journal of Clinical ... In Combination With Lenalidomide and Low-Dose Dexamethasone In Patients With Relapsed and/Or Refractory Multiple Myeloma: ...
It is not a neoplasm, but rather simply a mass. It most commonly affects the maxilla and mandible, though any bone may be ... Due to the standard of medical care and screening in developed countries, it is increasingly rare for primary ... The possibility of hyperparathyroidism should be considered in patients with recurrent or multiple giant cell epulides. ... ISBN 978-0-19-852794-7. Marcocci C, Cianferotti L, Cetani F (October 2012). "Bone disease in primary hyperparathyrodism". ...
Plasmacytoma, multiple myeloma, Waldenström macroglobulinemia and plasma cell leukemia are malignant neoplasms ("cancer") of ... The T cell-dependent processes are subdivided into primary and secondary responses: a primary response (meaning that the T cell ... Primary amyloidosis (AL) is caused by the deposition of excess immunoglobulin light chains which are secreted from plasma cells ... Frigyesi I (Jan 2014). "Robust isolation of malignant plasma cells in multiple myeloma". Blood. 123 (9): 1336-40. doi:10.1182/ ...
Of the above malignant characteristics, some elements do not apply to primary neoplasms of the brain: *Primary brain tumors ... Multiple metastatic tumors are generally treated with radiotherapy and chemotherapy rather than surgery and the prognosis in ... Due to the BBB, cancerous cells of a primary neoplasm cannot enter the bloodstream and get carried to another location in the ... Given the location of primary solid neoplasms of the brain in most cases a "do-nothing" option is usually not presented. ...
The most common endocrine gland manifestation is an ACTH-independent Cushing's syndrome due to primary pigmented nodular ... Epithelioid blue nevus List of cutaneous neoplasms associated with systemic syndromes Carney Syndrome at eMedicine Carney, J.; ... "The significance of multiple, recurrent, and "complex" cardiac myxomas". The Journal of thoracic and cardiovascular surgery. 91 ... "Pancreatic ductal and acinar cell neoplasms in Carney complex: a possible new association". J Clin Endocrinol Metab. 96 (11): ...
The primary long-term health hazard associated with exposure to ionizing radiation as a result of nuclear fallout is an ... Several severe adverse health effects, such as an increased incidence of cancers, thyroid diseases, CNS neoplasms, and possibly ... Arjun Mahkijani, "Science for the Vulnerable: Setting Radiation and Multiple Exposure Environmental Health Standards to Protect ... From 1951 - mid-1962, the Nevada Test Site (NTS) was a primary site used for both surface and above-ground nuclear testing, ...
Primary peritoneal carcinoma. *Prostate cancer. R. *Relay For Life. *Rhabdomyosarcoma. S. *Salivary gland neoplasm ...
... primary HIV infection - primary isolate - primaquine - proctitis - prodrome - prodrug - progressive multifocal ... multiple drug-resistant tuberculosis (MDR-TB) - mutation - myalgia - mycobacterium - mycobacterium avium complex (MAC) - ... neoplasm - nephrotoxic - neuralgia - neurological complications of AIDS - neuropathy - neutralization - neutralizing antibody ...
Neoplasms 60% increase in death rate 60% increased death rate from neoplasms. In 1999-2003, neoplasms accounted for 17% of all ... As there is no formal procedure for any community to record acceptance, the primary method of determining Indigenous population ... "Genomic and cranial phenotype data support multiple modern human dispersals from Africa and a southern route into Asia" (PDF) ... The attendance rate of Aboriginal students in primary and high schools has also remained steady. ...
CS1 maint: Multiple names: authors list (link) *. Lawrence Chin, MD and William Regine, MD, Editors (2008). Principles of ... It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... CS1 maint: Multiple names: authors list (link) CS1 maint: Extra text: authors list (link) ...
"Islet Cell Tumors of the Pancreas / Endocrine Neoplasms of the Pancreas". The Sol Goldman Pancreas Cancer Research Center. ... "Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1)" (PDF). The Journal of Clinical Endocrinology and ... and unknown primary". Neuroendocrinology. 95 (2): 157-76. PMID 22262022. doi:10.1159/000335597.. ... Farrell JJ, Fernández-del Castillo C (juni 2013). "Pancreatic cystic neoplasms: management and unanswered questions". ...
The primary risk from exposure to 131I is an increased risk of radiation-induced cancer in later life. Other risks include the ... US patent 4415805, Fertl, Walter H., "Method and apparatus for evaluating multiple stage fracturing or earth formations ... "Malignant and benign neoplasms of the thyroid in patients treated for hyperthyroidism: a report of the cooperative ... The primary emissions of 131I decay are thus electrons with a maximal energy of 606 keV (89% abundance, others 248-807 keV) and ...
CS1 maint: Multiple names: authors list (link). *^ "WHO Disease and injury country estimates". World Health Organization. 2009 ... "Male Genitals - Prostate Neoplasms". Pathology study images. University of Virginia School of Medicine. Archived from the ... A complete understanding of the causes of prostate cancer remains elusive.[17] The primary risk factors are obesity, age and ... The major downside to the 3-level system is that it does not account for multiple adverse parameters (e.g., high Gleason score ...
ignored (help)CS1 maint: Multiple names: authors list (link) *↑ Janny P, Cure H, Mohr M (1994). "Low grade supratentorial ... More than 90 percent of primary CNS malignancies in children are located within the brain.. Unknown parameter ,coauthors=. ... "CNS and Miscellaneous Intracranial and Instraspinal Neoplasms" (PDF). SEER Pediatric Monograph. National Cancer Institute. pp ... ignored (help)CS1 maint: Multiple names: authors list (link) *↑ Piepmeier J, Christopher S, Spencer D (1996). "Variations in ...
B21.7) HIV disease resulting in multiple malignant neoplasms. *(B21.8) HIV disease resulting in other malignant neoplasms ... A51.1) Primary anal syphilis. *(A51.2) Primary syphilis of other sites ... B20.7) HIV disease resulting in multiple infections. *(B20.8) HIV disease resulting in other infectious and parasitic diseases ... B21.) Human Immunodeficiency Virus (HIV) disease Resulting in malignant neoplasms *(B21.0) HIV disease resulting in Kaposi's ...
... deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of ... 2015). "Pre-conception folic acid and multivitamin supplementation for the primary and secondary prevention of neural tube ... "Maternal antenatal multiple micronutrient supplementation for long-term health benefits in children: a systematic review and ... the primary form found in the serum), methenyltetrahydrofolate, folinic acid, and folacin.[7][16][17][18] Other names include ...
They are known to grow in the liver, but this finding is usually a manifestation of metastatic disease from a primary carcinoid ... Carcinoid Syndrome is multiple in 1/5 cases,. Incidence of Gastric Carcinoid is increased in Achlorhydria,Hashimoto's ... cystic neoplasms: Serous microcystic adenoma. *Intraductal papillary mucinous neoplasm. *Mucinous cystic neoplasm ...
Some animals have multiple secondary (smaller) thymi in the neck; this phenomenon has been reported for mice and also occurs in ... One of the primary functions of the thymus is to prevent autoimmunity through the process of central tolerance, immunologic ... ISBN 0-7020-2606-9. Huete-Garin, A.; S.S. Sagel (2005). "Chapter 6: "Mediastinum", Thymic Neoplasm". In J.K.T. Lee; S.S. Sagel ... CS1 maint: Multiple names: authors list (link) Miller, J. F. (2002). "The discovery of thymus function and of thymus-derived ...
Studies of p53 dependent cell cycle arrest in response to DNA damage identified p21 as the primary mediator of downstream cell ... Xiong Y, Zhang H, Beach D (1992). "D type cyclins associate with multiple protein kinases and the DNA replication and repair ... Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes. Ligand. Growth factors. ... Metastatic canine mammary tumors display increased levels of p21 in the primary tumors but also in their metastases, despite ...
MEN(英语:Multiple endocrine neoplasia). *1(英语:Multiple endocrine neoplasia type 1) ... 腦垂腺(英语:Pituitary neoplasm). *垂體腺瘤(英语:Pituitary adenoma):泌乳素瘤(英语:Prolactinoma) ... 原發性中樞神經系統淋巴瘤(英语:Primary central nervous system lymphoma) ... 腫瘤:內分泌腺腫瘤(英语:Endocrine gland
Nervous tissue tumors/NS neoplasm/Neuroectodermal tumor (ICD-O 9350-9589) (C70-C72, D32-D33, 191-192/225) ... Patients with Lhermitte-Duclos disease and Cowden's syndrome may also have multiple growths on skin. The tumor, though benign, ...
Gray OM, McDonnell GV, Forbes RB (Aug 2006). "A systematic review of oral methotrexate for multiple sclerosis". Multiple ... This ability to bind covalently to DNA via their alkyl group is the primary cause for their anti-cancer effects.[32] DNA is ... Secondary neoplasm[edit]. Development of secondary neoplasia after successful chemotherapy or radiotherapy treatment can occur ... CS1 maint: Multiple names: authors list (link). *^ a b Gray O, McDonnell GV, Forbes RB (2004). Gray, Orla, ed. "Methotrexate ...
MRI or contrast enhanced CT classically shows multiple ring-enhancing lesions in the deep white matter. The major differential ... Nervous tissue tumors/NS neoplasm/Neuroectodermal tumor (ICD-O 9350-9589) (C70-C72, D32-D33, 191-192/225) ... A primary central nervous system lymphoma (PCNSL), also known as microglioma and primary brain lymphoma,[1] is a primary ... a b Primary CNS Lymphoma~treatment at eMedicine *^ Omuro, A; et al. (26 February 2015). "R-MPV followed by high-dose ...
The presence of multiple methylated CpG sites in CpG islands of promoters causes stable silencing of genes.[18] Silencing of a ... DNA damage appears to be the primary underlying cause of cancer.[39][40] If accurate DNA repair is deficient, DNA damages tend ... see malignant neoplasms). Thus, CpG island hyper/hypo-methylation in the promoters of DNA repair genes are likely central to ...
8560-8580) Complex epithelial neoplasms. Carcinoma In situ[edit]. The term carcinoma in situ (or CIS) is a term for cells that ... "Poorly differentiated carcinoma of unknown primary site". Retrieved 27 January 2014.. *^ Kuriakose MA, Hicks WL, Loree TR, Yee ... Carcinoma of unknown primary[edit]. The term carcinoma has also come to encompass malignant tumors composed of transformed ... Micrograph of a lung primary small cell carcinoma, a type of carcinoma. The clustered cancerous cells consist primarily of ...
... the effect of adjusting for multiple primaries". British Journal of Cancer. 105 (3): 460-465. doi:10.1038/bjc.2011.250. ISSN ... superior information as compared to CT scans when seeking information about headache to confirm a diagnosis of neoplasm, ... Evans RW (2009). "Diagnostic Testing for Migraine and Other Primary Headaches". Neurologic Clinics. 27 (2): 393-415. doi: ... Finally, data from a single CT imaging procedure consisting of either multiple contiguous or one helical scan can be viewed as ...
CS1 maint: Multiple names: authors list (link). *^ Kolata G (23 April 2009). "Advances Elusive in the Drive to Cure Cancer". ... They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... Surgery is the primary method of treatment for most isolated, solid cancers and may play a role in palliation and prolongation ... The primary ones include surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy and palliative care. ...
Of the above malignant characteristics, some elements do not apply to primary neoplasms of the brain: *Primary brain tumors ... Multiple metastatic tumors are generally treated with radiotherapy and chemotherapy rather than surgery and the prognosis in ... Due to the BBB, cancerous cells of a primary neoplasm cannot enter the bloodstream and get carried to another location in the ... There, these cells continue growing and dividing, becoming another invasive neoplasm of the primary cancer's tissue. Secondary ...
These can be considered in three general groups, namely primary immuno-dysregulation, decrease of the mucosal barrier and ... but the exact triggers for this process are unknown and are thought to be multiple and varied from one person to the next. This ... Salivary gland neoplasms *Benign: Basal cell adenoma. *Canalicular adenoma. *Ductal papilloma. *Monomorphic adenoma ... primary herpetic gingivostomatitis).[5] However, herpetiform ulceration is not caused by herpes viruses. As with all types of ...
It contradicts the hypothesis that E-cadherin loss is the initial or primary cause for EMT. In conclusion, the results suggest ... "Dynamic interaction of PTPmu with multiple cadherins in vivo". The Journal of Cell Biology. 141 (1): 287-96. doi:10.1083/jcb. ... Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes. Ligand. Growth factors. ...
en:Multiple drug resistance (14) → 다제내성 *en:Narcissistic personality disorder (41) → 자기애적 인격장애 ... en:Neoplasm (40) → 신생물 *en:Nephrotic syndrome (38) → 신증후군 *en:Nervous system disease (4) ... en:Primary care physician (3). *en:Primidone (17). *en:Privacy for research participants (2) ...
Buy the Kobo ebook Book Multiple Primary Malignant Neoplasms by at Indigo.ca, Canadas largest bookstore. + Get Free Shipping ... Title:Multiple Primary Malignant NeoplasmsFormat:Kobo ebookPublished:December 6, 2012Publisher:Springer Berlin Heidelberg ... Analyses of multiple primary malignancies serve as a guide to the probable anatomic location of a subsequent primary and help ... Studies of multiple primaries provide an efficient means for quantifying potentially harmful effects of current therapeutic ...
Synchronous primary carcinomas of endometrium and ovary Ovarian mucinous adenocarcinoma Immunohistochemistry Metastatic tumor ... 6] K.R. Lee and R.H. Young: "The distinction between primary and metastatic mucinous carcinomas of the ovary: gross and ... 14] J.D. Woodruff and C.G. Julian "Multiple malignancy in the upper genital canal", Am. J. Obstet. Gynecol., Vol. 103, (1969), ... We report a rare case of synchronous primary carcinomas of endometrium and ovary, followed by a metachronous retroperitoneal ...
Data have been presented on 261 cases in which multiple carcinomas of the colon were seen at the Mayo Clinic from January 1, ... Summary The literature concerning multiple colonic carcinomas has been reviewed. ... A marked tendency to multiplicity has been observed in carcinoma of the colon associated with multiple polyposis or with ... Multiple Primary Malignant Neoplasms: Their Incidence and Significance. by Charles G Moertel ...
Heredity and multiple primary malignant neoplasms: six cancer families. The American journal of the medical sciences. 1967 Sep; ... Heredity and multiple primary malignant neoplasms : six cancer families. / Lynch, H. T.; Krush, A. J.; Larsen, A. L. ... Lynch, H. T. ; Krush, A. J. ; Larsen, A. L. / Heredity and multiple primary malignant neoplasms : six cancer families. In: The ... title = "Heredity and multiple primary malignant neoplasms: six cancer families.",. author = "Lynch, {H. T.} and Krush, {A. J ...
If the download Multiple Primary Malignant Neoplasms: The Connecticut Experience, 1935-1964 then primary, you must update this ... download Multiple Primary Malignant Neoplasms: The which is with the ductus of passe processes and their possible field in the ... clinical download Multiple Primary Malignant Neoplasms: The is a storage education in which the severity manages held by his ... The download Multiple Primary Malignant Neoplasms: The stands Once expected. 2003 for buildings and global timeout as an while ...
... * ... In recent years, the number of patients exhibiting multiple primary malignant neoplasms has been increasing. The current study ... It is important to diagnose multiple primary malignant neoplasms as such patients generally exhibit a more favorable prognosis ... A rare case of eight multiple primary malignant neoplasms in a female patient: A case report and review of the literature. ...
Download Multiple Primary Malignant Neoplasms: The Connecticut by Bruce S. Schoenberg PDF. Home / Cancer / Download Multiple ... Multiple Primary Malignant Neoplasms: The Connecticut Experience, 1935-1964. Whilst requested why he robbed banks, an astute ... Extra info for Multiple Primary Malignant Neoplasms: The Connecticut Experience, 1935-1964 ... Read Online or Download Multiple Primary Malignant Neoplasms: The Connecticut Experience, 1935-1964 PDF ...
Multiple Primary Neoplasms: Role of Autopsy. Selected Sites, with Emphasis on Japan ... Aspects of the primary tumor. * Stroma, Generally a Non-Neoplastic Structure of the Tumor ... Recent advances The primary tumor comes into existence following in the role of DNA methylation in the generation of tumor ... Shared aspects of primary and secondary tumors. * Mechanisms of Cancer Invasion and Metastases ...
Multiple Myeloma. Neoplasms, Plasma Cell. Amyloidosis. Neoplasms by Histologic Type. Neoplasms. Hemostatic Disorders. Vascular ... Determine overall survival of patients with high-risk multiple myeloma, primary systemic amyloidosis, or light chain deposition ... Patients are stratified according to disease (high-risk multiple myeloma vs primary systemic amyloidosis vs both). ... 18 and over (patients with amyloidosis only OR patients with amyloidosis and multiple myeloma OR patients with multiple myeloma ...
Multiple Myeloma. Neoplasms, Plasma Cell. Amyloidosis. Neoplasms by Histologic Type. Neoplasms. Hemostatic Disorders. Vascular ... Determine overall survival of patients with high-risk multiple myeloma, primary systemic amyloidosis, or light chain deposition ... Patients are stratified according to disease (high-risk multiple myeloma vs primary systemic amyloidosis vs both). ... Primary Completion Date:. May 2012 (Final data collection date for primary outcome measure). ...
Neoplasms, Plasma Cell. Lenalidomide. Leukemia. Neoplasms by Histologic Type. Neoplasms. Multiple Myeloma. Lymphoproliferative ... Primary Purpose:. Treatment. Official Title:. A Pilot Study of Lenalidomide and Dexamethasone in Patients With Primary Plasma ... Lenalidomide and Dexamethasone in Primary Plasma Cell Leukemia. The safety and scientific validity of this study is the ... Total bilirubin greater than 2.0 mg/dL and/or SGOT or SGPT greater than two and a half times normal (unless due to primary ...
Search of: daratumumab multiple myeloma AND Neoplasms AND Daratumumab , ( Map: Nevada, United States ) - Modify Search. Expert ...
Multiple myeloma - Amyloidosis - MGUS - Myeloproliferative neoplasms - Essential thrombocythemia - Polycythemia vera - Primary ...
... study analyzed the genetic susceptibility of gene polymorphisms in three patients with multiple primary malignant neoplasms and ... Cases of more than three primary cancers are very rare. This ... in three patients with multiple primary malignant neoplasms Le ... Keywords: DNA damage repair; FA/BRCA pathway; Multiple primary malignant neoplasms; gene polymorphisms; second-generation whole ... of polymorphisms in genes associated with the FA/BRCA pathway in three patients with multiple primary malignant neoplasms Le ...
Multiple primary malignant neoplasms of the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in a ... the present report is the first one on this combination of primary malignant neoplasms.. KeywordsMetachronous Multiple primary ... Multiple primary malignant neoplasms of the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in a ... Multiple primary malignant neoplasms of the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in a ...
We report on the case of a 58-year-old male with multiple primary malignant neoplasms, who suffered from three histological ... As far as we know, the present report is the first one on this combination of primary malignant neoplasms. ... All neoplasms except the malignant neoplasm of the oral floor were well controlled. The patient died of cervical lymph node ... The first neoplasm was a squamous cell carcinoma of the glottis diagnosed in 2006. The second and third neoplasms were ...
Liver Neoplasms / Lung Neoplasms / Neoplasms, Multiple Primary Type of study: Case report Language: English Journal: J Postgrad ... Liver Neoplasms / Lung Neoplasms / Neoplasms, Multiple Primary Type of study: Case report Language: English Journal: J Postgrad ... Lung Neoplasms/complications , Lymphoma, Non-Hodgkin/complications , Male , Neoplasms, Multiple Primary , Splenic Neoplasms/ ... Multiple primary neoplasms. A case report of anaplastic bronchogenic carcinoma and generalized lymphosarcoma with review of ...
Colorectal Neoplasms , Follow-Up Studies , Humans , Incidence , Neoplasms, Multiple Primary , Retrospective Studies , Stomach ... Multiple Primary Malignant Neoplasm with Colorectal Cancer / 대한암학회지 Hee-Chul KIM; Chang-Nam KIM; Chun-Sik JUNG; Chang-Sik YU; ... A group of patients with multiple primary malignant neoplasms accompanied by colorectal cancer was analyzed to determine the ... The characteristics of colorectal cancers in multiple primary malignant neoplasm were similar to the colorectal cancers without ...
... multiple sclerosis, primary CNS tumors, or Chiari malformation, are occasionally seen. Sudden death can also be seen with ... Neoplasms: Lung, breast, GI tract (especially the colon), pancreas, ovary/uterus, testis, melanoma, lymphoma ... multiple), and with septic emboli (any location, multiple) ... Frequently, the latter situation occurs when the primary ... The other decedent is 80 years old and had a history of coronary artery disease with multiple cardiac bypass grafts. The death ...
Primary Completion Date Not Provided Eligibility Criteria ICMJE Inclusion Criteria:. *Patients must have solid tumors, ... Neoplasms, Thrombocytopenia, Multiple Myeloma, Malignant LymphomaSafety and Efficacy of (PN-152,243)/PN-196,444 in the ... Patients must have solid tumors, lymphomas or multiple myeloma who are receiving myelosuppressive treatment regimens requiring ... lymphomas or multiple myeloma who are receiving myelosuppressive treatment regimens requiring platelet transfusion support. ...
The Swedish Family-Cancer Database was used to analyse site-specific risk of second primary malignancies following 53 159 ... Multiple Myeloma / complications* * Neoplasms, Second Primary / epidemiology * Neoplasms, Second Primary / etiology* * ... Second primary neoplasms among 53 159 haematolymphoproliferative malignancy patients in Sweden, 1958-1996: a search for common ... The Swedish Family-Cancer Database was used to analyse site-specific risk of second primary malignancies following 53 159 ...
Neoplasm Proteins / genetics * Neoplasm Proteins / immunology * Neoplasm Proteins / metabolism * Nuclear Proteins * Ovarian ... Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes Am J Pathol. 2001 Mar; ... Although concurrent methylation of multiple genes was commonly seen, this did not seem to be due to a single CIMP phenotype. ... To determine the role of methylation in ovarian cancer, we have investigated the methylation status of 93 primary ovarian ...
... primary site variables, histologic type ICD-O-3, stage, and reporting delay. ... 2007 Multiple Primary and Histology Coding Rules.external icon Bethesda, MD: US Department of Health and Human Services, ... Hematopoietic and Lymphoid Neoplasm Database.external icon Bethesda, MD: US Department of Health and Human Services, National ... Primary Site Variables4-8. Beginning in diagnosis year 2010, some lymphoma and leukemia ICD-O-3 codes were updated based on ...
Plasma cell neoplasm / Multiple myeloma. Plasma Cell Neoplasms Treatment. Plasma cell neoplasms (including multiple myeloma) ... primary central nervous system non-Hodgkin lymphoma. Primary CNS Lymphoma Treatment. Primary central nervous system (CNS) ... Myeloproliferative neoplasms (incl. CML). Myeloproliferative Neoplasms Treatment. Chronic myeloproliferative neoplasms ... Myelodysplastic/ Myeloproliferative Neoplasms Treatment. Myelodysplastic/myeloproliferative neoplasms treatment options include ...
Preoperative diagnosis of multiple primary malignant neoplasm in gastrointestinal and breast cancers : Impact of FDG-PET/CT. / ... Preoperative diagnosis of multiple primary malignant neoplasm in gastrointestinal and breast cancers : Impact of FDG-PET/CT. In ... Preoperative diagnosis of multiple primary malignant neoplasm in gastrointestinal and breast cancers: Impact of FDG-PET/CT. ... keywords = "FDG, Multiple primary malignant neoplasm, PET/CT, Synchronous cancer",. author = "Gustavo Kishimoto and Koji ...
Keywords : Esophageal neoplasms; Carcinoma [squamous cell]; Neoplasms [multiple primary]; Respiratory system. · abstract in ... Multiple primary tumors were encountered in 10 (3.8%) patients. All patients were male and the mean age at the time of the ... three synchronous and five metachronous multiple primary carcinomas were detected. The esophagus was the second primary tumor ... RIBEIRO JR., Ulysses et al. Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive ...
Mesenchymal neoplasms of the kidney are rare, and most represent sporadic angiomyolipomas. A few haemangiomas have been ... Neoplasms, Multiple Primary. Nephrectomy. Receptors, Cytoplasmic and Nuclear / metabolism. Retrospective Studies. Tumor Markers ... AIMS: Mesenchymal neoplasms of the kidney are rare, and most represent sporadic angiomyolipomas. A few haemangiomas have been ... Kidney Neoplasms / complications, metabolism, pathology*. Male. Microfilament Proteins / metabolism. Middle Aged. ...
Multiple Myeloma and Plasma Cell Neoplasm. *refractory multiple myeloma. *stage I multiple myeloma ... Primary refractory or relapsed multiple myeloma after first-line treatment with. standard chemotherapy. - Ineligible for higher ... Histologically confirmed multiple myeloma OR. - Primary systemic amyloidosis resulting in significant organ dysfunction and ... responsive vs refractory or relapsed) and diagnosis (multiple myeloma vs primary systemic. amyloidosis).. Following a course of ...
Colonic Neoplasms / pathology*. Female. Humans. Liver Neoplasms / secondary. Neoplasms, Multiple Primary / pathology*. Saudi ...
... and 15,893 females with cancer of the digestive system were followed for the subsequent development of independent primary ... In: Multiple Primary Malignant Neoplasms. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans ... Small Intestine Primary Site Digestive System Histologic Confirmation Primary Malignant Neoplasm These keywords were added by ... with cancer of the digestive system were followed for the subsequent development of independent primary malignant neoplasms; ...
  • We report on the case of a 58-year-old male with multiple primary malignant neoplasms, who suffered from three histological types of malignant neoplasm in six organs, namely the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in chronological order. (duhnnae.com)
  • All neoplasms except the malignant neoplasm of the oral floor were well controlled. (duhnnae.com)
  • The incidence of multiple primary malignant neoplasm has increased in recent decades. (bvsalud.org)
  • The etiologies and epidemiologies of multiple primary malignant neoplasm are still remained to be verified. (bvsalud.org)
  • The characteristics of colorectal cancers in multiple primary malignant neoplasm were similar to the colorectal cancers without other cancers . (bvsalud.org)
  • Objective: The reports of multiple primary malignant neoplasm (MPMN) have increased due to the development of imaging technologies that have influenced the extension of the 5-year relative survival rate for all cancers. (elsevier.com)
  • Conclusions FDG PET/CT was useful for finding multiple primary malignant neoplasm with a relatively high sensitivity. (elsevier.com)
  • Kishimoto, G, Murakami, K & Sakamoto, S 2011, ' Preoperative diagnosis of multiple primary malignant neoplasm in gastrointestinal and breast cancers: Impact of FDG-PET/CT ', Dokkyo Journal of Medical Sciences , vol. 38, no. 1, pp. 9-16. (elsevier.com)
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. (icd10data.com)
  • One important factor in maintaining increased survival is the early detection and treatment of new primary tumors which may develop. (indigo.ca)
  • Warren S and Gates O: Multiple primary malignant tumors: a survey of the literature and statistical study. (spandidos-publications.com)
  • The critical growth and progression and this volume explores the role of the cell surface in secondary tumor formation is characteristics of primary tumors as well as the shared reviewed as are important advances in the molecular biology characteristics of both primary and secondary tumors. (springer.com)
  • This study will test the safety and efficacy of this investigational drug in the prevention of thrombocytopenia in patients with solid tumors, lymphomas or multiple myeloma who are receiving myelosuppressive treatment regimens requiring platelet transfusion support. (pfizer.com)
  • To determine the role of methylation in ovarian cancer, we have investigated the methylation status of 93 primary ovarian tumors at ten loci using methylation-specific polymerase chain reaction (MSP). (nih.gov)
  • All 264 patients with squamous cell carcinoma of the esophagus, treated in the Gastrointestinal Surgery, Esophagus section, of the "Hospital das Clínicas" (São Paulo University Medical School, Brazil), between 1979 and 1989 were analyzed retrospectively with regards to the occurrence of multiple primary tumors in the upper aerodigestive tract. (scielo.br)
  • Multiple primary tumors were encountered in 10 (3.8%) patients. (scielo.br)
  • Inquiry regarding other malignancies, associated with panendoscopy should be carry out prior to the treatment of the first primary to diagnose simultaneous or synchronous primary tumors, and careful follow-up should be performed after treatment of the first primary to detect new tumors in these high-risk patients. (scielo.br)
  • A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. (curehunter.com)
  • Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) tumors derived from choroid plexus epithelium that are seen predominantly in children. (medscape.com)
  • [ 2 , 3 ] In adults, they account for less than 1% of primary intracranial neoplasms, whereas choroid plexus tumors represent up to 5% of pediatric brain tumors, and up to 20% of those arising in children aged 1 year and younger. (medscape.com)
  • This phenomenon attracted the investigative interest of such pioneers as Harvey Cushing who recognized that pituitary tumors may cause acromegaly and Charles Mayo who associated hyper tension with adrenal medullary neoplasms. (exlibris.ch)
  • For lymphoid neoplasms, this secondary or distant involvement is akin to metastasis for solid tumors and does not alter the primary site assigned by the physician or determined using the PH Rules. (cancer.gov)
  • Primary tumors were induced and promoted concurrently in 35 uPA -/- deficient and 35 uPA +/+ wild-type mice using a single application of 7,12-dimethylbenz(a)anthracene followed by repetitive applications of croton oil. (aacrjournals.org)
  • For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned. (icd10data.com)
  • Carney complex is a rare autosomal dominant disorder characterized by multiple tumors, including cardiac and extracardiac myxomas, skin lesions, and various endocrine disorders. (hindawi.com)
  • The initial clinical impression was the presence of multiple metastatic brain tumors or infections such as neurosyphilis and bacterial abscesses, so additional diagnostic workups were performed sequentially. (frontiersin.org)
  • Primary Liver Tumors. (aacrjournals.org)
  • To study protein expression in a large number of hepatocellular tumors, tissue arrays were constructed from formalin-fixed, paraffin-embedded tissues on all hepatocellular neoplasms in the Johns Hopkins Surgical pathology files with available tissues from 1985 to 2001, including 73 typical hepatocellular carcinomas, 15 hepatic adenomas, and 13 fibrolamellar carcinomas. (aacrjournals.org)
  • However, primary tumors may also occur outside of the gastrointestinal tract, in other intra-abdominal locations, especially in the omentum and mesentery. (uniprot.org)
  • Primary pituitary tumors are relatively rare and mainly benign. (endocrine-abstracts.org)
  • The aim was to study the primary pituitary tumors presenting during a 10-year period in a single center. (endocrine-abstracts.org)
  • The archives of all patients with primary pituitary tumors having been hospitalized from 01.01.2000 to 30.06.2010 in the Department of Endocrinology and Metabolism of Metaxa Hospital were studied. (endocrine-abstracts.org)
  • In conclusion, primary pituitary tumors are rare and mainly benign. (endocrine-abstracts.org)
  • 3. Torre D. Multiple sebaceous tumors. (meduniver.com)
  • Multiple endocrine neoplasia type 2A (MEN2A) is a condition with inherited autosomal dominant mutations in RET (rearranged during transfection) gene that predisposes the carrier to extremely high risk of medullary thyroid cancer (MTC) and other MEN2A-associated tumors such as parathyroid cancer and/or pheochromocytoma. (cancerindex.org)
  • Myeloproliferative neoplasms (incl. (yalecancercenter.org)
  • Chronic myeloproliferative neoplasms treatments vary and depend upon the specific diagnosis. (yalecancercenter.org)
  • Increased risk of lymphoid neoplasms in patients with Philadelphia chromosome-negative myeloproliferative neoplasms," Cancer Epidemiology Biomarkers and Prevention , vol. 18, no. 7, pp. 2068-2073, 2009. (hindawi.com)
  • Primary central nervous system (CNS) lymphoma treatment options include radiation, chemotherapy, and corticosteroids. (yalecancercenter.org)
  • Learn more about the treatment of newly diagnosed and recurrent primary CNS lymphoma cancer in this expert-reviewed summary. (yalecancercenter.org)
  • Epidermal invasion in histiocytoma, or presence of simultaneous multiple histiocytomas, especially in aged dogs, can appear similar to MF or non-epidermotropic cutaneous lymphoma (NECL). (wikipedia.org)
  • Other names that are sometimes used for WM include: lymphoplasmacytic lymphoma, lymphoplasmacytic leukemia, macroglobulinemia of Waldenstr ö m, primary macroglobulinemia, Waldenstr ö m's syndrome, Waldenstr ö m's purpura, or hyperglobulinemic purpura. (encyclopedia.com)
  • WM is a type of plasma cell neoplasm or B-cell lymphoma. (encyclopedia.com)
  • The lymphoid neoplasms with plasmacytic differentiation are: 1) Plasmablastic lymphoma: The most common of these lymphoid neoplasms. (wikipedia.org)
  • 2) Plasmablastic plasma cell lymphoma or plasmablastic plasmacytoma: A lymphoid neoplasm that disseminates widely like the plasma cell lesions in multiple myeloma or is localized like the plasma cell lesions in plasmacytoma. (wikipedia.org)
  • 6) Human herpesvirus 8-positive diffuse large B-cell lymphoma, not otherwise specified: This lymphoid neoplasm usually arises from the lymphoproliferative disease, idiopathic multicentric Castleman disease. (wikipedia.org)
  • Except for human herpesvirus 8-positive diffuse large B-cell lymphoma, not otherwise specified, these lymphoid neoplasms are often associated with Epstein-Barr virus infection of the malignant plasmablastic cells. (wikipedia.org)
  • A marked tendency to multiplicity has been observed in carcinoma of the colon associated with multiple polyposis or with chronic ulcerative colitis. (magrudy.com)
  • It is important to diagnose multiple primary malignant neoplasms as such patients generally exhibit a more favorable prognosis compared with metastatic carcinoma patients. (spandidos-publications.com)
  • He JJ: Meta analysis of 2025 cases with multiple primary colorectal carcinoma. (spandidos-publications.com)
  • The first neoplasm was a squamous cell carcinoma of the glottis diagnosed in 2006. (duhnnae.com)
  • The remaining three neoplasms were diagnosed in 2010, namely a squamous cell carcinoma of the oral floor, an adenocarcinoma of the prostate, and a squamous cell carcinoma of the esophagus. (duhnnae.com)
  • Wang HZ, Huang XF, Wang Y et al (2004) Clinical features, diagnosis, treatment and prognosis of multiple primary colorectal carcinoma. (springer.com)
  • As the study subjects were very heterogeneous regarding their first and second neoplasms, we performed two subgroup analyses in the most common groups: Subjects with lymphoid leukaemia as a fist neoplasm (n=10) and subjects with thyroid carcinoma as second neoplasm (n=6). (aacrjournals.org)
  • Cholangiocarcinoma was the most commonly diagnosed neoplasm, followed by hepatocellular carcinoma and hemangiosarcoma. (scielo.br)
  • We present a case report describing a patient with 3 separate primary cancers: transitional cell carcinoma of the bladder, mesothelioma of the tunica vaginalis, and adenocarcinoma of the lung. (jaoa.org)
  • In this clinical case, the authors describe the evolution of an asymptomatic patient with several synchronous tumours (a GEJ primary adenocarcinoma, a low grade urothelial carcinoma in situ , a localized squamous cell lung carcinoma and 2 IPMNs). (scirp.org)
  • Considering the non-invasive nature of the urothelial primary carcinoma discovered, the nodule was regarded as synchronous lung cancer, cT1aN0M0. (scirp.org)
  • Results: Of 778, 32 patients were diagnosed with additional unexpected cancers, which 27 (3.5%) were incidental double cancers and 5 (0.64%) had triple primary lesions. (elsevier.com)
  • Physicians should pay special attention to rule out the presence of unexpected additional primary lesions in initial staging work-up for colorectal cancer. (elsevier.com)
  • When linear scleroderma occurs on the head, it is referred to as linear scleroderma en coup de sabre, given the resemblance of the skin lesions to the stroke of a sabre. (aappublications.org)
  • Double primary malignant lesions of the esophagus. (springer.com)
  • Carney complex (CNC) is one of those familial forms characterized by multiple cardiac myxomas, skin lesions, and various endocrine disorders [ 2 ]. (hindawi.com)
  • However, although rare, multiple lesions that simultaneously occur in both of these regions may be the cause of acute hemiparesis, and the clinical symptoms can often be misdiagnosed as a stroke. (frontiersin.org)
  • In addition, the correct diagnosis of these multiple central nervous system (CNS) lesions is very challenging if they are caused by infection from an unexpected microorganism. (frontiersin.org)
  • We evaluated an elderly healthy woman who presented with acute hemiparesis and multiple brain and spinal cord lesions that were confirmed to occur from an infection with Propionibacterium acnes . (frontiersin.org)
  • In this report, the differential diagnosis and histopathological findings are discussed for these multiple CNS lesions in this healthy woman. (frontiersin.org)
  • An initial brain magnetic resonance imaging (MRI) scan revealed multiple small lesions in both the frontal cortex and subcortex that primarily involved the right internal capsule. (frontiersin.org)
  • Delayed regression of multiple histiocytomas can occur and lesions can persist for up to 10 months. (wikipedia.org)
  • Intracranial lesions mimicking neoplasms. (thefreelibrary.com)
  • The synchronous occurence of primary carcinomas of endometrium and ovary is well recognized. (edu.pl)
  • We report a rare case of synchronous primary carcinomas of endometrium and ovary, followed by a metachronous retroperitoneal MPNST. (edu.pl)
  • Synchronous primary neoplasms of the bladder, skin and breast in a male patient: a case report. (spandidos-publications.com)
  • Balschun K, Haag J, Wenke AK, von Schönfels W, Schwarz NT and Röcken C: KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary colorectal cancers diagnostic and therapeutic implications. (spandidos-publications.com)
  • Two simultaneous, three synchronous and five metachronous multiple primary carcinomas were detected. (scielo.br)
  • Consequently, the incidence of synchronous tumours (by definition, primary tumours with different histologies) is thought to be on the rise. (scirp.org)
  • On the other hand, the possibility of synchronous tumours on radiology exams being interpreted as metastasis of a single primary neoplasm has great implications on treatment choices and prognosis, raising the issue of when to biopsy masses found during the staging process. (scirp.org)
  • Butrym, Aleksandra 2018-03-01 00:00:00 Multiple myeloma is a hematological malignancy, which sometimes creates difficulties in diagnosis, based on the presence of monoclonal protein in serum/urine and plasmocyte infiltration in the bone marrow, and on the other hand, synchronous cancers are also a diagnostic challenge. (deepdyve.com)
  • After completion of the chemotherapy for breast cancer, the patient was observed and short time after that multiple myeloma was diagnosed as a synchronous cancer. (deepdyve.com)
  • PURPOSE: This phase II trial is studying how well giving melphalan together with autologous stem cell transplantation works in treating patients with multiple myeloma or primary systemic amyloidosis. (clinicaltrials.gov)
  • Determine overall survival of patients with high-risk multiple myeloma, primary systemic amyloidosis, or light chain deposition disease treated with two courses of modified high-dose melphalan and autologous peripheral blood stem cell transplantation. (clinicaltrials.gov)
  • Patients are stratified according to disease (high-risk multiple myeloma vs primary systemic amyloidosis vs both). (clinicaltrials.gov)
  • Primary systemic amyloidosis patients: Patients receive G-CSF SC daily beginning on day 1 and continuing through the day before the last leukapheresis. (clinicaltrials.gov)
  • Determine the response rate in patients with multiple myeloma or primary systemic amyloidosis treated with high-dose chemotherapy with autologous hematopoietic stem cell support. (knowcancer.com)
  • OUTLINE: Patients are stratified according to disease response to prior treatment (responsive vs refractory or relapsed) and diagnosis (multiple myeloma vs primary systemic amyloidosis). (knowcancer.com)
  • Patients with primary systemic amyloidosis who are not responding to or are unable to tolerate treatment do not proceed to the second course of therapy. (knowcancer.com)
  • PROJECTED ACCRUAL: Approximately 60-75 patients (25 for responsive disease stratum, 25 for refractory or relapsed disease stratum, and 10-25 for primary systemic amyloidosis stratum) will be accrued for this study within 3 years. (knowcancer.com)
  • Determine the maximum tolerated dose (MTD) of high-dose melphalan administered with amifostine in patients with primary systemic amyloidosis undergoing autologous peripheral blood stem cell transplantation. (knowcancer.com)
  • transplantation may be effective treatment for primary systemic (AL) amyloidosis. (bioportfolio.com)
  • phase II trial is studying how well tandem (two) autologous stem cell transplantation works in treating patients with primary systemic (AL) amyloidosis. (bioportfolio.com)
  • This secondary involvement excludes rare primary lymphoid neoplasms of spleen, lung involvement, liver or CNS (see PH Rules). (cancer.gov)
  • Lymphoid neoplasms with plasmablastic differentiation were classified by the World Health Organization, 2017 as a sub-grouping of several distinct but rare lymphomas in which the malignant cells are B-cell lymphocytes that have become plasmablasts, i.e. immature plasma cells. (wikipedia.org)
  • Due to their malignant nature, however, the plasmablasts in lymphoid neoplasms with plasmablastic differentiation do not mature into plasma cells or form antibodies but rather uncontrollably proliferate in and damage various tissues and organs. (wikipedia.org)
  • Analyses of multiple primary malignancies serve as a guide to the probable anatomic location of a subsequent primary and help define characteristics of the individual at high risk for multiple primary cancer. (indigo.ca)
  • Hu NC, Hsieh SC, Chen TJ and Chang JY: Multiple primary malignancies including colon, stomach, lung, breast, and liver cancer: a case report and literature review. (spandidos-publications.com)
  • Irimie A, Achimas-Cadariu P, Burz C and Puscas E: Multiple primary malignancies - epidemiological analysis at a single tertiary institution. (spandidos-publications.com)
  • In any case, the investigation suggests an association between heavy consumption of alcohol and tobacco and multiple primary malignancies of the oral cavity, pharynx, respiratory system, and upper digestive system. (redecorayvende.com)
  • The Swedish Family-Cancer Database was used to analyse site-specific risk of second primary malignancies following 53 159 haematolymphoproliferative disorders (HLPD) diagnosed between 1958 and 1996. (nih.gov)
  • Strategic innovations in the fight against cancer have resulted in improved diagnosis of multiple primary malignancies (MPM). (springer.com)
  • Individuals affected by Li-Fraumeni syndrome who are successfully treated for cancer must understand the significant risk of developing further primary malignancies and the need for close medical follow-up care. (medscape.com)
  • All colorectal cancer (CRC) survivors have an increased risk of developing second primary malignancies (SPMs). (frontiersin.org)
  • Tumours are considered multiple primary malignancies if arising in different sites and/or are of a different histology or morphology group. (frontiersin.org)
  • CRC patients with diabetes mellitus, especially those with older age, and early stages of colon cancer, should be screened for second primary malignancies more often than the standard population. (frontiersin.org)
  • The development of multiple primary malignancies in an individual is rare and unfortunate, and the care of such a patient presents specific challenges. (jaoa.org)
  • The International Agency for Research on Cancer (IARC) describes such malignancies as a second neoplasm of different topology and/or morphology in a patient ( 2 ). (aerzteblatt.de)
  • Heredity and multiple primary malignant neoplasms: six cancer families. (elsevier.com)
  • Kapsinow R: Multiple primary cancer. (spandidos-publications.com)
  • Owing to recent advances in diagnostic and surgical techniques for cancer, a patient diagnosed with two or more neoplasms is not rare. (duhnnae.com)
  • A group of patients with multiple primary malignant neoplasms accompanied by colorectal cancer was analyzed to determine the relationship between certain cancers and colorectal cancer . (bvsalud.org)
  • Recent studies on colorectal and gastric cancer have defined a CpG island methylator phenotype (CIMP), which involves the targeting of multiple genes by promoter hypermethylation. (nih.gov)
  • Cancer of the esophagus: its association with other primary tumours. (springer.com)
  • Kan JY, Hsieh JS, Pan YS (2006) Clinical characteristics of patients with sporadic colorectal cancer and primary cancers of other organs. (springer.com)
  • Ueno M, Muto T, Oya M et al (2003) Multiple primary cancer: an experience at the Cancer Institute Hospital with special reference to colorectal cancer. (springer.com)
  • Chiang JM, Yeh CY, Changchien CR et al (2004) Clinical features of second other-site primary cancers among sporadic colorectal cancer patients - a hospital-based study of 3,722 cases. (springer.com)
  • Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. (medscape.com)
  • Treatment of the primary neoplasm with radiotherapy or chemotherapy is an established risk factor for second neoplasms (SNs) after childhood cancer. (aacrjournals.org)
  • Primary Breast Cancer During Pregnancy: Does it Affect Outcome? (esmo.org)
  • Procedures employed here illustrate an approach for reproducibly obtaining material for pathophysiological studies of salivary gland neoplasms, and other less common epithelial cancer types, that can be executed without compromising pathological examination of patient specimens. (biologists.org)
  • Although genome-wide association studies (GWAS) have identified many common genetic variants associated with various cancer sites, no study has examined the association of these genetic variants with risk of multiple primary cancers (MPC). (aacrjournals.org)
  • In the diagnosis of cancer, recognition of early warning signs is primarily the responsibility of the primary care physician (PCP). (jaoa.org)
  • Physicians in almost every medical specialty play a role in the detection of cancer, but the PCP is best positioned to recognize the earliest warning signs of neoplasm and is most often the individual who refers the patient to the appropriate specialist. (jaoa.org)
  • We present a case report of a patient with concurrent breast cancer and multiple myeloma.A 68-year-old woman was admitted to the hospital with diagnosis of left breast cancer in first stage of the disease. (deepdyve.com)
  • Patient was first treated for breast cancer, then subsequently for multiple myeloma (2 lines therapy: CTD and VMP). (deepdyve.com)
  • In recent years, the number of patients exhibiting multiple primary malignant neoplasms has been increasing. (spandidos-publications.com)
  • 6] K.R. Lee and R.H. Young: "The distinction between primary and metastatic mucinous carcinomas of the ovary: gross and histologic findings in 50 cases", Am. J. Surg. (edu.pl)
  • Summary The literature concerning multiple colonic carcinomas has been reviewed. (magrudy.com)
  • Data have been presented on 261 cases in which multiple carcinomas of the colon were seen at the Mayo Clinic from January 1, 1944, through December 31, 1953. (magrudy.com)
  • The second and third neoplasms were urothelial carcinomas of the right renal pelvis and urinary bladder, respectively, diagnosed in 2008. (duhnnae.com)
  • 7. Endocrine neoplasms: carcinomas of the thyroid. (exlibris.ch)
  • Eight hundred and twenty-five patients with primary carcinomas of the head and neck area were studied. (ovid.com)
  • Why study patients with multiple primary cancers? (indigo.ca)
  • Hisada M, Garber JE, Fung CY, Fraumeni JF Jr and Li FP: Multiple primary cancers in families with Li-Fraumeni syndrome. (spandidos-publications.com)
  • Cases of more than three primary cancers are very rare. (cdc.gov)
  • The clinical data and whole genome sequence of three patients (1 with 5 primary cancers, 1 with 4 primary cancers, and 1 with 3 primary cancers) were aligned with a series of databases. (cdc.gov)
  • In the patients with double primaries, extracolonic cancers were found in the stomach (16), hepatobiliary system(12), urologic system(6), gynecologic organ(6) and others. (bvsalud.org)
  • In the patients with triple primaries, extracolic cancers were found in the stomach (5), uterus (2), lung (2) and others. (bvsalud.org)
  • Our findings showed some clustering between first and second primaries among Epstein-Barr virus-, ultraviolet radiation- and immunosuppression-related cancers. (nih.gov)
  • J. W. Berg, "The incidence of multiple primary cancers. (hindawi.com)
  • Analyses were made of all varieties of malignant neoplasms in the kindreds and compared with the prevalence of comparable cancers from the New York State Tumor Registry (exclusive of New York City) and compared similarly with tumor expectations including all the known varieties of hereditary cancers. (annals.org)
  • Diagnosis of multiple cancers of the esophagus and stomach (abstract, Russian). (springer.com)
  • Multiple primary cancers account for approximately 16% of all incident cancers in the United States. (aacrjournals.org)
  • We report the diagnosis and progression of 3 histologically different primary cancers in 1 patient over the course of 15 years. (jaoa.org)
  • To our knowledge, the present report is the first description of a case of 3 primary cancers that includes a mesothelioma of the tunica vaginalis. (jaoa.org)
  • AIMS: Mesenchymal neoplasms of the kidney are rare, and most represent sporadic angiomyolipomas. (biomedsearch.com)
  • Common mesenchymal neoplasms arising in the gastrointestinal tract, most often in the stomach. (uniprot.org)
  • Primary hepatobiliary neoplasms (PHN) are uncommon in cats, and originate in hepatocytes, intra- and extrahepatic bile ducts, mesenchymal cells, and cells of neuroendocrine origin. (scielo.br)
  • Mucinous cystic neoplasms of the liver and extrahepatic biliary tree have recently been re-defined by WHO as epithelial cystic tumours with ovarian-type mesenchymal stroma. (intechopen.com)
  • Currently, mucinous cystic neoplasms of the liver are defined as epithelial cystic tumours associated with ovarian-type mesenchymal stroma. (intechopen.com)
  • Exception: Abstract multiple primaries when a nodal MALT (C770-779, 9699/3) occurs before or after an extranodal MALT (all other sites, 9699/3). (cancer.gov)
  • Abstract a new primary. (cancer.gov)
  • Abstract one primary, plasma cell myeloma, 9732/3. (cancer.gov)
  • The patients with family history of malignancy were 10 cases and the rate in the triple primaries seemed to be higher than double primaries. (bvsalud.org)
  • Radiologic demonstration of multiple foci of malignancy in the esophagus. (springer.com)
  • Fibrosarcoma of bone is a rare primary malignancy. (sarcomahelp.org)
  • The mean overall survival after the diagnosis of the second primary was 2.8 months (SD = 0.89). (scielo.br)
  • Here we describe 3 pediatric patients with linear scleroderma en coup de sabre who presented with neurologic abnormalities before or concurrent with the diagnosis of their skin disease. (aappublications.org)
  • A diagnosis of linear scleroderma en coup de sabre was made based on the characteristic skin changes observed. (aappublications.org)
  • 8. Primary hyperparathyroidism: pathophysiology, differential diagnosis and management. (exlibris.ch)
  • Matching was by first neoplasm, age and year of first diagnosis. (aacrjournals.org)
  • The radiologic finding of erosion of the skull base by this mass lesion may have contributed to its interpretation as a destructive neoplasm, with the differential diagnosis including chondrosarcoma, metastatic lesion, osteosarcoma, and meningioma. (thefreelibrary.com)
  • However, the histology in this case ruled out a diagnosis of neoplasm. (thefreelibrary.com)
  • Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression. (nih.gov)
  • We studied the contribution of the PAs to the malignant phenotype through the chemical induction of melanocytic neoplasms in uPA-deficient mice. (aacrjournals.org)
  • This list provides a brief summary of the major changes in the revised Hematopoietic and Lymphoid Neoplasm Coding Manual and Database released in May 2018. (cancer.gov)
  • PURPOSE: This phase I trial is studying the side effects and best dose of vaccine therapy when given with or without cyclophosphamide in treating patients with recurrent or refractory multiple myeloma. (bioportfolio.com)
  • Determine the safety and toxicity of Edmonston vaccine strain oncolytic measles virus encoding thyroidal sodium iodide symporter (MV-NIS) when administered with or without cyclophosphamide in patients with relapsed or refractory multiple myeloma. (bioportfolio.com)
  • four were multifocal and four had concurrent renal epithelial neoplasms. (biomedsearch.com)
  • Conditionally reprogrammed cell (CRC) technology enables establishment of primary epithelial cell cultures from patient material. (biologists.org)
  • To enhance the knowledge of medical society on the mucinous cystic neoplasms of the liver, here we aim to summarise contemporary data on these tumours, including the current definition and classification [ 1 ], the recent molecular genetic findings [ 3 , 4 ] as well as the practical issues of clinical presentation, diagnostic approach, treatment and prognosis. (intechopen.com)
  • Mucinous cystic neoplasms of the liver [ 1 ], formerly known as bile duct/biliary cystadenoma and biliary cystadenocarcinoma [ 2 ], represent an enigmatic entity, characterised by unknown origin and peculiar morphology including the presence of ovarian-type stroma. (intechopen.com)
  • Multiple medullary plasmacytomas, Multiple plasmacytomas, Multiple plasmacytomas of bone removed. (cancer.gov)
  • Choroid plexus neoplasms can produce hydrocephalus and increased intracranial pressure by a number of mechanisms, including obstruction of normal cerebrospinal fluid (CSF) flow, overproduction of CSF by the tumor itself, local expansion of the ventricles, or spontaneous hemorrhage. (medscape.com)
  • A broad spectrum of nonneoplastic conditions can radiologically and clinically mimic an intracranial neoplasm. (thefreelibrary.com)
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified ( C25.9 ). (icd10data.com)
  • Endoscopic ultrasound-guided fine-needle aspiration (FNA) is now widely used as a primary tool to diagnose pancreatic neoplasms. (cancerindex.org)
  • Föredrag download Multiple Primary Malignant Neoplasms: The Connecticut Experience, 1935-1964 1977 ' remembers a synovial server of patterns of the benign in treatment and History, So in reality, life, loss, and home. (lunauppsala.se)
  • Histiocytic sarcoma Localized histiocytic sarcoma diffuse histiocytic sarcoma Histiocytoma is a common, benign, cutaneous neoplasm in dogs. (wikipedia.org)
  • All patients had benign neoplasms. (endocrine-abstracts.org)
  • For example, endocrine neoplasms secrete active hormones or hormone precursors which produce clinical manifestations most familiar to endocrinologists. (exlibris.ch)
  • Different RET gene mutation-induced multiple endocrine neoplasia type 2A in 3 Chinese families. (cancerindex.org)
  • New note 1 indicating the presence of multiple plasmacytomas is diagnostic of plasma cell myeloma (9732/3) and not plasmacytoma (9731, 9734). (cancer.gov)
  • They include monoclonal gammopathy of undetermined significance (MGUS), isolated plasmacytoma of the bone, extramedullary plasmacytoma, and multiple myeloma. (cigna.com)
  • 4 , 5 ] For this reason, when treatment is indicated, systemic treatment must be considered for all patients with symptomatic plasma cell neoplasms. (cigna.com)
  • Multiple histiocytomas may look like cutaneous histiocytosis, although morphologically histiocytomas are consistently epidermotropic and commonly epidermally invasive, these are not features of cutaneous histiocytosis. (wikipedia.org)
  • Multiple cutaneous nodules may be distributed over the entire body, but are especially prevalent in the scrotum, nasal apex, nasal planum and eyelids. (wikipedia.org)
  • Cutaneous sebaceous neoplasms. (meduniver.com)
  • Hamartoma Syndrome, Multiple" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Hamartoma Syndrome, Multiple" by people in Harvard Catalyst Profiles by year, and whether "Hamartoma Syndrome, Multiple" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Hamartoma Syndrome, Multiple" by people in Profiles. (harvard.edu)
  • Within 4-12 weeks after receiving the second course of high-dose chemotherapy, multiple myeloma patients receive maintenance therapy consisting of interferon alfa SC 3 days a week, after blood counts recover. (knowcancer.com)
  • All symptoms of multiple myeloma were interpreted as a secondary effect of chemotherapy. (deepdyve.com)
  • Studies of multiple primaries provide an efficient means for quantifying potentially harmful effects of current therapeutic modalities. (indigo.ca)
  • Restricted availability of cell and animal models is a rate-limiting step for investigation of salivary gland neoplasm pathophysiology and therapeutic response. (biologists.org)
  • To reflect on the challenges of a case with multiple integrated diagnostic and therapeutic approaches and to bring to consideration the increasing prevalence of similar situations. (scirp.org)
  • The esophagus was the second primary tumor in nine patients. (scielo.br)
  • The high sensitivity and specificity of modern diagnostic technologies are such that second primary malignant neoplasms can be identified in their early stages, during follow-up for the first primary malignant tumor and even if the symptomatology is vague or the findings incidental. (springer.com)
  • In turn, compared to 30 years ago, more patients are being diagnosed with a second primary tumor [1-4]. (springer.com)
  • Leave a comment A First rapid download Multiple Primary Malignant Neoplasms: The Connecticut Experience, 1935-1964 1977 would call when discussing the star. (lunauppsala.se)
  • Moertel C (1977) Multiple primary malignant neoplasms. (springer.com)
  • The coexistence of chronic lymphocytic leukemia and myeloproliperative neoplasms: a retrospective multicentric GIMEMA experience," The American Journal of Hematology , vol. 86, no. 12, pp. 1007-1012, 2011. (hindawi.com)
  • Multiple primary carcinomata of the colon duodenum and larynx associated with keratoacanthoma of the face. (meduniver.com)
  • Waldenstrom Macroglobulinemia (9761/3) now has primary site of C421 (bone marrow). (cancer.gov)
  • We can exclude primary diseases of bone because they involve multiple different locations in bone. (uiowa.edu)
  • Determine the disease-free survival and overall survival of patients with multiple myeloma treated with this regimen. (knowcancer.com)
  • Einhorn J, Jakobson P. Multiple primary malignant tumours. (springer.com)
  • Per the WHO classification of Tumours of Haematopoietic and Lymphoid Tissues (October 2017), the presence of multiple plasmacytomas is diagnostic of plasma cell myeloma (9732/3). (cancer.gov)
  • The c-MET expression was homogeneous in multiple metastases from the same patients. (nih.gov)