Neoplasm Staging
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Neoplasms
Endosonography
Ultrasonography of internal organs using an ultrasound transducer sometimes mounted on a fiberoptic endoscope. In endosonography the transducer converts electronic signals into acoustic pulses or continuous waves and acts also as a receiver to detect reflected pulses from within the organ. An audiovisual-electronic interface converts the detected or processed echo signals, which pass through the electronics of the instrument, into a form that the technologist can evaluate. The procedure should not be confused with ENDOSCOPY which employs a special instrument called an endoscope. The "endo-" of endosonography refers to the examination of tissue within hollow organs, with reference to the usual ultrasonography procedure which is performed externally or transcutaneously.
Lymphatic Metastasis
Neoplasms, Cystic, Mucinous, and Serous
Tomography, X-Ray Computed
Prognosis
Fluorodeoxyglucose F18
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
Positron-Emission Tomography
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Neoplasms, Multiple Primary
Radiopharmaceuticals
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Lymph Nodes
Sensitivity and Specificity
Neoplasms, Second Primary
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Adenocarcinoma, Mucinous
Mediastinum
Mediastinoscopy
Gastrointestinal Neoplasms
Immunohistochemistry
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Ovarian Neoplasms
Colorectal Neoplasms
Neoplasm Metastasis
Neoplasm Recurrence, Local
Myeloproliferative Disorders
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Lymph Node Excision
Biopsy, Needle
Sentinel Lymph Node Biopsy
Carcinoma
Survival Analysis
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Carcinoma, Papillary
Cystadenoma
Neoplasms, Connective and Soft Tissue
Neoplasms, Plasma Cell
Carcinoma, Pancreatic Ductal
Magnetic Resonance Imaging
Multimodal Imaging
Adenocarcinoma, Papillary
Soft Tissue Neoplasms
Neoplasms, Glandular and Epithelial
Cystadenoma, Mucinous
Biopsy, Fine-Needle
Treatment Outcome
Bone Marrow Neoplasms
Preoperative Care
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Biopsy
Neoplasms, Experimental
Prospective Studies
Neoplasms, Vascular Tissue
Follow-Up Studies
Tomography, Emission-Computed
Neoplasms, Radiation-Induced
Hodgkin Disease
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Reproducibility of Results
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Carcinoma, Squamous Cell
Antigens, Neoplasm
Testicular Neoplasms
Neoplasms, Muscle Tissue
Pleural Neoplasms
Cystadenocarcinoma, Mucinous
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Hematologic Neoplasms
Neuroendocrine Tumors
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Neoplasms, Adnexal and Skin Appendage
Vascular Neoplasms
Common Bile Duct Neoplasms
Neoplasms, Germ Cell and Embryonal
Lymphography
Palatal Neoplasms
Head and Neck Neoplasms
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Cystadenocarcinoma
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Muscle Neoplasms
Diagnostic Imaging
Combined Modality Therapy
False Negative Reactions
Endometrial Neoplasms
Whole Body Imaging
Heart Neoplasms
Neoplasm Grading
Cystadenoma, Serous
A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)
Disease Progression
Dog Diseases
Carcinoma, Non-Small-Cell Lung
Adenoma, Oxyphilic
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
Cerebellar Neoplasms
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
Neoplasms, Adipose Tissue
Laparoscopy
Meningeal Neoplasms
Disease-Free Survival
Kaplan-Meier Estimate
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Laryngeal Neoplasms
Sarcoma
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Carcinoma, Acinar Cell
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Spinal Cord Neoplasms
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Nervous System Neoplasms
Neoplasm Seeding
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Janus Kinase 2
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
Neoadjuvant Therapy
Thymoma
A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed)
Hemangiosarcoma
Adenocarcinoma, Follicular
Leiomyosarcoma
A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)
Myelodysplastic-Myeloproliferative Diseases
Peripheral Nervous System Neoplasms
Cerebral Ventricle Neoplasms
Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.
Lymphoma, T-Cell
Carcinoma, Neuroendocrine
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Neck Dissection
Dissection in the neck to remove all disease tissues including cervical LYMPH NODES and to leave an adequate margin of normal tissue. This type of surgery is usually used in tumors or cervical metastases in the head and neck. The prototype of neck dissection is the radical neck dissection described by Crile in 1906.
Carcinoma, Bronchogenic
Carcinosarcoma
Pancreaticoduodenectomy
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Risk Factors
Multivariate Analysis
Lipoma
Carcinoma, Renal Cell
False Positive Reactions
Fatal Outcome
Gastrectomy
Neoplasm Transplantation
Proportional Hazards Models
Radiotherapy, Adjuvant
Neoplasms by Site
Incidental Findings
Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.
Carcinoembryonic Antigen
Histiocytic Disorders, Malignant
Immunoenzyme Techniques
Lymphoma, B-Cell
Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma. (1/18612)
The association of p53 abnormalities with the prognosis of patients with non-small cell lung carcinoma (NSCLC) has been extensively investigated to date, however, this association is still controversial. Therefore, we investigated the prognostic significance of p53 mutations through exons 2 to 11 and p53 protein expression in 103 cases of stage I NSCLC. p53 mutations were detected in 49 of 103 (48%) tumors. Two separate mutations were detected in four tumors giving a total of 53 unique mutations in 49 tumors. Ten (19%) of mutations occurred outside exons 5-8. Positive immunohistochemical staining of p53 protein was detected in 41 of 103 (40%) tumors. The concordance rate between mutations and protein overexpression was only 69%. p53 mutations, but not expression, were significantly associated with a shortened survival of patients (P<0.001). Furthermore, we investigated the correlation between the types of p53 mutations and prognosis. p53 missense mutations rather than null mutations were associated with poor prognosis (P < 0.001 in missense mutations and P=0.243 in null mutations). These results indicated that p53 mutations, in particular missense mutations, rather than p53 expression could be a useful molecular marker for the prognosis of patients with surgically resected stage I NSCLC. (+info)Comparative efficacy of positron emission tomography with FDG and computed tomographic scanning in preoperative staging of non-small cell lung cancer. (2/18612)
OBJECTIVE: To determine the sensitivity, specificity, and accuracy of positron emission tomography with 2-fluorine-18-fluorodeoxyglucose (PET-FDG) in the preoperative staging (N and M staging) of patients with lung cancer. The authors wanted to compare the efficacy of PET scanning with currently used computed tomography (CT) scanning. MATERIALS AND METHODS: Results of whole-body PET-FDG imaging and CT scans were compared with histologic findings for the presence or absence of lymph node disease or metastatic sites. Sampling of mediastinal lymph nodes was performed using mediastinoscopy or thoracotomy. RESULTS: PET-FDG imaging was significantly more sensitive, specific, and accurate for detecting N disease than CT. PET changed N staging in 35% and M staging in 11% of patients. CT scans helped in accurate anatomic localization of 6/57 PET lymph node abnormalities. CONCLUSION: PET-FDG is a reliable method for preoperative staging of patients with lung cancer and would help to optimize management of these patients. Accurate lymph node staging of lung cancer may be ideally performed by simultaneous review of PET and CT scans. (+info)A blind comparison of the effectiveness of endoscopic ultrasonography and endoscopy in staging early gastric cancer. (3/18612)
BACKGROUND/AIMS: Endoscopic ultrasonography is expected to be useful for invasion depth staging of early gastric cancer. A prospective blind study of the staging characteristics of endoscopy and endoscopic ultrasonography for early gastric cancer was performed. METHODS: Findings of endoscopy and endoscopic ultrasonography using a 20 MHz thin ultrasound probe were independently reviewed and the results of 52 early gastric cancer lesions analysed. RESULTS: The overall accuracy rates in invasion depth staging of early gastric cancer were 63% for endoscopy and 71% for endoscopic ultrasonography. No statistically significant differences were observed in overall accuracy. Endoscopic ultrasonography tended to overstage, and lesions that were classified as mucosal cancer by endoscopic ultrasonography were very likely (95%) to be limited to the mucosa on histological examination. All 16 lesions staged as mucosal cancer independently but coincidentally by both methods were histologically limited to the mucosa. CONCLUSIONS: Endoscopic ultrasonography is expected to compensate for the understaging of lesions with submucosal invasion that are endoscopically staged as mucosal cancer. (+info)Evidence of improving survival of patients with rectal cancer in france: a population based study. (4/18612)
BACKGROUND: Over the past 20 years there have been many changes in the management of rectal cancer. Their impact on the overall population is not well known. AIMS: To determine trends in management and prognosis of rectal cancer in two French regions. SUBJECTS: 1978 patients with a rectal carcinoma diagnosed between 1978 and 1993. METHODS: Time trends in treatment, stage at diagnosis, operative mortality, and survival were studied on a four year basis. A non-conditional logistic regression was performed to obtain an odds ratio for each period adjusted for the other variables. To estimate the independent effect of the period a multivariate relative survival analysis was performed. RESULTS: Over the 16 year period resection rates increased from 66.0% to 80.1%; the increase was particularly noticeable for sphincter saving procedures (+30.6% per four years, p=0.03). The percentage of patients receiving adjuvant radiotherapy increased from 24.0% to 40.0% (p=0.02). The proportion of patients with Dukes' type A cancer increased from 17. 7% to 30.6% with a corresponding decrease in those with more advanced disease. Operative mortality decreased by 31.1% per four years (p=0.03). All these improvements have resulted in a dramatic increase in relative survival (from 35.4% for the 1978-1981 period to 57.0% for the 1985-1989 period). CONCLUSIONS: Substantial advances in the management of rectal cancer have been achieved, but there is evidence that further improvements can be made in order to increase survival. (+info)Immunocytochemically detected free peritoneal tumour cells (FPTC) are a strong prognostic factor in gastric carcinoma. (5/18612)
We prospectively investigated the prognostic significance of free peritoneal tumour cells (FPTC) in a series of 118 patients with completely resected gastric carcinoma. Immunocytochemistry with the monoclonal antibody Ber-Ep4 was performed on cytospins from intraoperative peritoneal lavage specimens. Twenty-three patients (20%) had FPTC which was significantly correlated with pT and pN categories, stage, tumour size, lymphatic invasion, Lauren and WHO classifications and perigastric adipose tissue metastases. The median survival time for all FPTC positive compared with negative patients was significantly shorter (11 compared with >72 months), with estimated 5-year survival rates of 8% vs. 60%. None of the patients with FPTC had an early gastric cancer. In advanced tumour subgroups without and with serosal invasion (n = 59 and 35), there were 19% and 34% with FPTC. Multivariate survival analysis showed nodal status, FPTC, mesenteric lymphangiosis, and lymph node metastasis to the compartment III to be independent prognostic factors with relative risks of 6.6, 4.5, 2.9 and 2.2 respectively. Recurrent disease occurred in 91% of FPTC-positive and in 38% of FPTC-negative patients. FPTC had a positive predictive value of 91% and a specificity of 97% for tumour recurrence. FPTC is a strong negative, independent prognostic indicator for survival in gastric carcinoma. (+info)Elevated serum thymidine kinase levels identify a subgroup at high risk of disease progression in early, nonsmoldering chronic lymphocytic leukemia. (6/18612)
Chronic lymphocytic leukemia (CLL) shows a remarkably heterogeneous clinical outcome; survival ranges from several months in advanced stages to more than 10 years in early stages. The Binet and Rai staging systems distinguish three major prognostic subgroups, but do not accurately predict the individual risk of disease progression in early CLL (Binet stage A or Rai stage 0 to II). Because most newly diagnosed CLL patients present with early disease, it seems desirable to search for additional prognostic factors to identify early CLL patients at high risk of rapid progression. It has been shown that elevated serum thymidine kinase (s-TK) levels predict disease progression in CLL. Therefore, this study aimed to assess the prognostic value of s-TK in 122 previously untreated patients with Binet stage A CLL (mean age +/- SD, 58.7 +/- 8.5 years). In univariate analyses, 18 of the 22 parameters investigated predicted progression-free survival (PFS). In a stepwise multiple regression analysis, only three parameters provided independent prognostic information on PFS: s-TK greater than 7.1 U/L; presence of lymphadenopathy; and white blood cell (WBC) count greater than 75, 000/microL. When added to the classification of smoldering versus nonsmoldering CLL, s-TK levels separated two groups within the group of nonsmoldering stage A patients: patients with s-TK values greater than 7.1 U/L had a median PFS of 8 months, whereas patients with s-TK values +info)Detection of occult lymph node metastases in esophageal cancer by minimally invasive staging combined with molecular diagnostic techniques. (7/18612)
BACKGROUND AND OBJECTIVES: Lymph node metastases are the most important prognostic factor in patients with esophageal cancer. Histologic examination misses micrometastases in up to 20% of lymph nodes evaluated. In addition, non-invasive imaging modalities are not sensitive enough to detect small lymph nodes metastases. The objective of this study was to investigate the use of reverse transcriptase-polymerase chain reaction (RT-PCR) of messenger RNA (mRNA) for carcinoembryonic antigen (CEA) to increase the detection of micrometastases in lymph nodes from patients with esophageal cancer. METHODS: RT-PCR of CEA mRNA was performed in lymph nodes from patients with malignant and benign esophageal disease. Each specimen was examined histopathologically and by RT-PCR and the results were compared. RESULTS: Metastases were present in 29 of 60 (48%) lymph nodes sample by minimally invasive staging from 13 patients with esophageal cancer when examined histopathologically. RT-PCR identified nodal metastases in 46 of these 60 (77%) samples. RT-PCR detected CEA mRNA in all 29 histologically positive samples and in 17 histologically negative lymph nodes. All lymph nodes from patients with benign disease (n = 15) were negative both histopathologically and by RT-PCR. The stage of two patients was reclassified based on the RT-PCR results, which identified lymph node spread undetected histopathologically. Both of these patients developed recurrent disease after resection of the primary tumor. CONCLUSIONS: RT-PCR is more sensitive than histologic examination in the detection of lymph node metastases in esophageal cancer and can lead to diagnosis of a more advanced stage in some patients. The combination of minimally invasive surgical techniques in combination with new molecular diagnostic techniques may improve our ability to stage cancer patients. (+info)Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer. (8/18612)
BACKGROUND: Conventional cytologic analysis of sputum is an insensitive test for the diagnosis of non-small-cell lung cancer (NSCLC). We have recently demonstrated that polymerase chain reaction (PCR)-based molecular methods are more sensitive than cytologic analysis in diagnosing bladder cancer. In this study, we examined whether molecular assays could identify cancer cells in bronchoalveolar lavage (BAL) fluid. METHODS: Tumor-specific oncogene mutations, CpG-island methylation status, and microsatellite alterations in the DNA of cells in BAL fluid from 50 consecutive patients with resectable (stages I through IIIa) NSCLC were assessed by use of four PCR-based techniques. RESULTS: Of 50 tumors, 28 contained a p53 mutation, and the identical mutation was detected with a plaque hybridization assay in the BAL fluid of 39% (11 of 28) of the corresponding patients. Eight of 19 adenocarcinomas contained a K-ras mutation, and the identical mutation was detected with a mutation ligation assay in the BAL fluid of 50% (four of eight) of the corresponding patients. The p16 gene was methylated in 19 of 50 tumors, and methylated p16 alleles were detected in the BAL fluid of 63% (12 of 19) of the corresponding patients. Microsatellite instability in at least one marker was detected with a panel of 15 markers frequently altered in NSCLC in 23 of 50 tumors; the identical alteration was detected in the BAL fluid of 14% (three of 22) of the corresponding patients. When all four techniques were used, mutations or microsatellite instability was detected in the paired BAL fluid of 23 (53%) of the 43 patients with tumors carrying a genetic alteration. CONCLUSION: Although still limited by sensitivity, molecular diagnostic strategies can detect the presence of neoplastic cells in the proximal airway of patients with surgically resectable NSCLC. (+info)
1076 Independent validation of the 2010 TNM staging system for renal cell carcinoma : does it improves predictive accuracy in...
Impact of the 7th Edition AJCC Staging Classification on the NCCN Clinical Practice Guidelines in Oncology for Gastric and...
TNM Staging System - AMA Manual of Style
TNM Staging System - AMA Manual of Style
Do Largest Basal Tumor Diameter and the American Joint Committee on Cancers Cancer Staging Influence Prognostication by Gene...
A Phase II Trial of Cetuximab and Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer - Full Text View -...
The American Joint Committee on Cancer: updating the strategies in cancer staging. - Semantic Scholar
The diversity between curatively resected pancreatic head and body-tail cancers based on the 8th edition of AJCC staging system...
New Staging System IDs cSCC Risk in Transplant Patients - MPR
Comparison of 6th and 7th AJCC TNM Staging Classification for Carcinoma of the Stomach in China | Springer for Research &...
Lung cancer (staging - IASLC 8th edition) | Radiology Reference Article | Radiopaedia.org
What is Tumor Staging and Why is it Important?
Variation between multidisciplinary tumor boards in clinical staging and treatment recommendations for patients with locally...
Prognostic and predictive factors in colorectal cancer | Postgraduate Medical Journal
Imaging Tests for the Staging of Colorectal Cancer | Effective Health Care Program
Gastric carcinoma: imaging diagnosis, staging and assessment of treatment response | [email protected]
Welcome to CDC stacks
Predictors of pathologic complete response after preoperative concurrent chemoradiotherapy of rectal cancer: a single center...
PROGNOSTIC VALUE OF A CARDIAC DAMAGE STAGING CLASSIFICATION IN.... CCC ePoster Library. Bernard J. Oct 26 2019; 280535
CorpusCarcinoma - Schema Index
Acting, Stage Production, Writing, Marketing, or Set Design - English on Stage
CDC - Cancer - NPCR - TNM 7th Edition Staging API
Piloting a Deep Learning Model for Predicting Nuclear BAP1 Immunohistochemical Expression of Uveal Melanoma from Hematoxylin...
Patient Resource Publishing : TNBC Staging ::.
T staging using MSCT and EUS.A. MSCT-T1 tumor: Transver | Open-i
Patient Resource Publishing : Uterine Cancer Overview ::.
Surgical Treatment for Lung Cancer | Columbia University Department of Surgery
Inclusion of Comorbidity in a Staging System for Head and Neck Cancer
Characteristics of patients with missing information on stage: a population-based study of patients diagnosed with colon, lung...
SEVEN THAT SPELLS You Must Do This on Stage Vol. 1 reviews
Lactating on Stage - The MPA Project
Exemestane, Letrozole, or Anastrozole in Treating Postmenopausal Women With Clinical Stage II and III Estrogen Receptor...
Carcinoma of the bronchus 60 years later | Thorax
Effect of mammographic service screening on stage at presentation of breast cancers in Sweden - Fingerprint - Taipei...
Run The Jewels Were Attacked On Stage At SXSW [Update: Killer Mike Suffers Injury]
AJCC Cancer Staging Manual | Mahul B. Amin | Springer
Is there a stage 5 cancer - Things You Didnt Know
Pinup Pageant Guide: Posing on Stage - Miss MonMon
Ovarian Cancer Staging - New Kids Center
Read Microsoft Word - 537 544 ObroceaFl TNM staging.doc
Staging Essay - Free Examples for Every Purpose | WePapers
Beyond Five - Staging and grading
AJCC - AJCC News
Thijs Van Dalen and Neoplasm Staging - Free people check - Yasni.com
Cancer Staging
PAK1 activation is correlated with tumor stage at prese | Open-i
AJCC - AJCC Cancer Staging Manual in the Literature
2018 Collin County MLK Unity Walk
LeAnn Rimes -- Unstable on Stage at X Factor? | TMZ.com
Aging | Validation of the 8|sup|th|/sup| edition of the American Joint Committee on Cancer Pathological Prognostic Staging for...
PRIME PubMed | Prognostic significance of the lymph node ratio in stage IV colorectal cancer patients who have undergone...
Clinicopathological Factors Associated with Recurrence and Prognosis after R0 Resection for Stage IV Colorectal Cancer with...
How Aggressive Should We Be in Patients With Stage IV Colorectal Cancer? - PubMed
YUHSpace: Prognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging...
Genomic Profiling of Stage II Colorectal Cancer Identifies Candidate Genes Associated with Recurrence-Free Survival, Tumor...
Comparison of the Prognostic Value of Platelet-Related Indices in Biliary Tract Cancer Undergoing Surgical Resection
Refubium - Accuracy of various lymph node staging criteria in rectal cancer with magnetic
resonance imaging
Universidade do Minho: Preoperative staging of rectal cancer with MRI: correlation with pathologic staging
Vaccine Therapy in Treating Patients With Stage IIB, Stage III, or Stage IV Colorectal Cancer - Full Text View - ClinicalTrials...
Breast Cancer Stage 3 Treatment Options | Modern Cancer Hospital Guangzhou, China
Breast Cancer Stage 4 Treatment Options | Modern Cancer Hospital Guangzhou, China
Stage III Breast Cancer | Texas Oncology
Elevated ALCAM Shedding in Colorectal Cancer Correlates with Poor Patient Outcome | Cancer Research
A Patient-Centered Methodology That Improves the Accuracy of Prognostic Predictions in Cancer
Sparrho | Lymph node density vs. the American Joint Committee on Canc
Microrna-9-5p-CDX2 axis: A useful prognostic biomarker for patients with stage II/III colorectal cancer<...
Colon cancer staging - Wikipedia
Modest value of staging investigations in heavily node positive early breast cancer patients | OncologyPRO
Impact of lymph-node positive kidney cancer on survival - Kidney Cancer Support Network
NCT03971409 | Stage III Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer, Stage IV...
MOL] Effective imaging study for determining the T and N stages of esop [00884]
Clinical implications of endoscopic ultrasonography non-traversability in patients with locoregional esophageal cancer...
NCCN Quick Guide™ | Breast Cancer - Stage IV
Prevention and Treatment of Cancer-Related Infections in: Journal of the National Comprehensive Cancer Network Volume 6 Issue 2...
ajcc stage ii rectal cancer 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
A phase II study of AZD2171 [cediranib] in breast cancer stage IV (10006202) - AdisInsight
Budgets and Economics Archives - Rave Reviews Home Staging
ajcc stage iv rectal cancer 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Stages of Breast Cancer - Stages of Condition | Susan G. Komen®
Stage II Colon Cancer | Texas Oncology
Molecular staging individualizing cancer management - Mejia - 2012 - Journal of Surgical Oncology - Wiley Online Library
Efikasnost lečenja bolesnika u IIIA stadijumu nemikrocelularnog karcinoma bronha operisanih nakon neoadjuvantne terapije
Predicting the prognosis of lung cancer: The evolution of tumor, node and metastasis in the molecular age-challenges and...
Gene expression profiles as predictors of poor outcomes in stage II colorectal cancer: A systematic review and meta-analysis
svn commit: r838378 - in /websites/staging/ctakes/trunk/content: ./ ctakes/3.0.0/user-guide-3.0.html
Variations of discordance of the clinical TNM stage with the pathological TNM stage between Japanese designated cancer...
Combination Chemotherapy With or Without Darbepoetin Alfa in Treating Women With Stage III Breast Cancer
Video Gallery : Diseases of the Colon & Rectum
Choledochoduodenostomy
Gore RM, Shelhamer RP (October 2007). "Biliary tract neoplasms: diagnosis and staging". Cancer Imaging. 7 Spec No A (Special ...
Hyperbilirubinemia in adults
Gore, Richard M. (2007). "Biliary tract neoplasms: diagnosis and staging". Cancer Imaging. 7 (Special Issue A): S15-S23. doi: ... End stage liver disease models also include hyperbilirubinemia as a critical parameter in prognosis of cirrhosis. Moreover, ... Hepatitis B and C have similar symptoms as hepatitis A but onsets later when the stage reaches chronic liver cirrhosis. ...
Neuroendocrine tumor
Currently there is no one staging system for all neuroendocrine neoplasms. Well-differentiated lesions generally have their own ... For example, gastric NEC and mixed adenoneuroendocrine cancers are staged as primary carcinoma of the stomach. TNM staging of ... G1 and G2 neuroendocrine neoplasms are called neuroendocrine tumors (NETs) - formerly called carcinoid tumours. G3 neoplasms ... Although there are many kinds of NETs, they are treated as a group of tissue because the cells of these neoplasms share common ...
Renal cell carcinoma
"Magnetic resonance imaging in the diagnosis and staging of renal and perirenal neoplasms". Radiology. 154 (3): 709-15. doi: ... Staging can follow the TNM staging system, where the size and extent of the tumour (T), involvement of lymph nodes (N) and ... Also, it can use overall stage grouping into stage I-IV, with the 1997 revision of AJCC described below: At diagnosis, 30% of ... The most aggressive stage of renal cancer is believed to be the one in which the tumour is mixed, containing both clear and ...
Analgesic nephropathy
Blohmé I, Johansson S (November 1981). "Renal pelvic neoplasms and atypical urothelium in patients with end-stage analgesic ... In Stage 5 chronic kidney disease patients renal replacement therapy may become necessary.[citation needed] Analgesics are a ... As the use of phenacetin declined, so too did the prevalence of analgesic nephropathy as a cause of end-stage kidney disease. ... Analgesic nephropathy was once a common cause of kidney injury and end-stage kidney disease in parts of Europe, Australia, and ...
Clark's level
Melanoma Staging Systems. National Cancer Institute. A resource on Clark's levels and Breslow's depth. Original article from ... Articles using infobox templates with no data rows, Histopathology, Melanocytic nevi and neoplasms, Dermatologic terminology, ... Clark's level is a staging system, which describes the level of anatomical invasion of the melanoma in the skin. It was ... Staging of melanomas Breslow's depth "NCI Dictionary of Cancer Terms". National Cancer Institute. Retrieved 2020-02-13. " ...
Gallbladder disease
As most early-stage cancers are asymptomatic, neoplasm of the gallbladder is found in late stages and has a poor prognosis. ... Gallbladder cancer (Malignant neoplasm of the gallbladder) is rare, and most of the time is adenocarcinoma. ... When an individual has symptomatic gallbladder disease and early-stage cancer, a cholecystectomy is utilized. A cholecystectomy ...
Animal testing
The National Library of Medicine also explains how a neoplasm is difficult to diagnose at an early stage. Understanding the ... In turn, such applied studies may be an early stage in the drug discovery process. Examples include: Genetic modification of ... The main species used is the zebrafish, Danio rerio, which are translucent during their embryonic stage, and the African clawed ... Humans and Zebrafish share neoplasm similarities which is why they are used for research. The National Library of Medicine ...
Endoglin
TGF beta can act as a tumor suppressor in the premalignant stage of the benign neoplasm by inhibiting its growth and inducing ...
Ameloblastic fibroma
A stage in the development of a hamartomatous odontoma or a true neoplasm? Critical analysis of 162 previously reported cases ... It is a neoplasm, meaning it is a mass of abnormal growth of cells or tissue. If the mass contains hard dental tissues they are ... The bud-cap stage of normal development shows ameloblasts forming palisades of columnar cells adjacent to a starry-like, ... The histopathology of ameloblastic fibromas resembles the stages of normal tooth development (6). These mixed lesions consist ...
Trophoblastic neoplasm
2000 Anatomical staging is commonly used to evaluate stage of GTN. Stage I - Disease confined to the uterus Stage II - GTN ... Surgery treatment is most common initial method for some types of the disease but it depends on the stage of the tumor. Common ... "Gestational Trophoblastic Disease Stages". www.cancer.org. Retrieved 2020-12-17. "Choriocarcinoma: MedlinePlus Medical ... with or without known genital tract involvement Stage IV - All other metastatic sites All types of gestational trophoblastic ...
Mung bean
"Spectrum of Epithelial Neoplasms in End-Stage Renal Disease: An Experience From 66 Tumor-Bearing Kidneys With Emphasis on ... Thrips infest mung bean both in the seedling and in flowering stages. During the seedling stage, thrips infest the seedling's ... Insect pests attack mung bean at all crop stages from sowing to storage stage and take a heavy toll on crop yield. Some insect ... The perfect harvesting stage is when 90% of pods' colour in one yield has been black. Mung bean can use a harverster for ...
Neuroplastic surgery
Immediate Single-Stage Cranioplasty Following Calvarial Resection for Benign and Malignant Skull Neoplasms Using Customized ... Murphy RJ, Wolfe KC, Liacouras PC, Grant GT, Gordon CR, Armand M.Computer-assisted single-stage cranioplasty. Conf Proc IEEE ... A Craniomaxillofacial Surgical Assistance Workstation for Enhanced Single-Stage Reconstruction Using Patient-Specific Implants ...
Endoscopic submucosal dissection
In Japan, ESD is now gaining acceptance as the standard endoscopic resection technique for stomach neoplasms in an early stage ... The resected size and shape can be controlled, en bloc resection is possible even in a large neoplasm, and neoplasms with ... So this technique can be applied to the resection of complex neoplasms such as large neoplasms, ulcerative non-lifting ... especially for large or ulcerative neoplasms. Recently, the ESD technique is applied to esophageal or colorectal neoplasms in ...
Blastic plasmacytoid dendritic cell neoplasm
A leukemic phase of the disease is a common feature of end stage and post-therapy relapsing BPDCN. There are three types of ... The neoplasm occurs in individuals of all ages but predominates in the elderly; in children, it afflicts males and females ... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy. It was initially regarded as a form of ... Blastic plasmacytoid dendritic cell neoplasm is an aggressive malignancy with features of cutaneous lymphoma (e.g. malignant ...
Neoplasm
"Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The term neoplasm is a synonym of tumor. Neoplasia denotes the process of the formation of neoplasms/tumors, and the process is ... The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that ...
Breslow's depth
Cancer staging, Dermatologic terminology, Histopathology, Melanocytic nevi and neoplasms). ... However, for staging purposes, the most recent AJCC guidelines use cutoffs of 1 mm, 2 mm, and 4 mm to divide patients into ... Currently, the standard Breslow's depth has been replaced by the AJCC depth, in the AJCC staging system of melanoma. Originally ... Currently, Breslow's depth is included in the AJCC staging guidelines for melanoma as a major prognostic factor. Tumor depth is ...
Eye neoplasm
Melanomas (choroidal, ciliary body and uveal) - In the early stages there may be no symptoms (the person does not know there is ... Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be ...
Myeloproliferative neoplasm
Prefibrotic Stage PMF, Overt Fibrotic Stage Essential thrombocythemia (ET) Chronic eosinophilic leukemia (not otherwise ... In MPNs, the neoplasm (abnormal growth) starts out as benign and can later become malignant. As of 2016, the World Health ... Myeloproliferative neoplasms (MPNs) are a group of rare blood cancers in which excess red blood cells, white blood cells or ... Myelo refers to the bone marrow, proliferative describes the rapid growth of blood cells and neoplasm describes that growth as ...
Microarray analysis techniques
Genevestigator is a public tool to perform contextual meta-analysis across contexts such as anatomical parts, stages of ... development, and response to diseases, chemicals, stresses, and neoplasms. Significance analysis of microarrays (SAM) is a ...
Papillary urothelial neoplasm of low malignant potential
Pathologic grading and staging tumors are: graded by the degree of cellular atypia (G1->G3), and staged:[citation needed] ... Papillary urothelial neoplasm of low malignant potential (PUNLMP) is an exophytic (outward growing), (microscopically) nipple- ... As their name suggests, PUNLMPs are neoplasms, i.e. clonal cellular proliferations, that are thought to have a low probability ... MacLennan GT, Kirkali Z, Cheng L (April 2007). "Histologic grading of noninvasive papillary urothelial neoplasms". Eur. Urol. ...
Brain tumor
... are in the early stages of development. Brain Tumor Nervous system neoplasm List of brain tumor cases "Adult Brain Tumors ... Neoplasms will often show as differently colored masses (also referred to as processes) in CT or MRI results.[citation needed] ... Examinations in this stage may include the eyes, otolaryngological (or ENT) and electrophysiological exams. The use of ... More generally a neoplasm may cause release of metabolic end products (e.g., free radicals, altered electrolytes, ...
Man Alive! (1952 film)
... an analogy is made between a badly functioning car and a man with physical symptoms that could lead to neoplasm. Various stages ...
Carcinoma
... s are usually staged with Roman numerals. In most classifications, Stage I and Stage II carcinomas are confirmed when ... Lobular and Medullary Neoplasms (8550-8559) Acinar cell neoplasms (8560-8580) Complex epithelial neoplasms The term carcinoma ... Adnexal and Skin appendage Neoplasms (8430-8439) Mucoepidermoid Neoplasms (8440-8490) Cystic, Mucinous and Serous Neoplasms ( ... For example, the colon and bladder cancer staging system relies on depth of invasion, staging of breast carcinoma is more ...
Virtual karyotype
18q LOH is an established biomarker associated with high risk of tumor recurrence in stage II colon cancer. Figure 7 shows a ... Renal epithelial neoplasms have characteristic cytogenetic aberrations that can aid in classification. See also Atlas of ... "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms." Nature 13 Aug 2009; 460, 904-909. Gondek LP, Tiu R, ... Subtypes 2A and 2B: found in unfavorable widespread neuroblastoma, stages 3 and 4, with 11q loss and 17q gain without MYCN ...
Seminoma
The analysis of tumor markers also helps in staging. The preferred treatment for most forms of stage 1 seminoma is active ... It is a malignant neoplasm and is one of the most treatable and curable cancers, with a survival rate above 95% if discovered ... Regardless of treatment strategy, stage 1 seminoma has nearly a 100% cure rate. Stage 2 seminoma is indicated by the presence ... Stage 3 seminoma is characterized by the presence of metastasis outside the retroperitoneum-the lungs in "good risk" cases or ...
Acute myeloid leukemia
When these mutations occur, it is likely in the early stages of AML. Such mutations include in the DNA demethylase TET2 and the ... Page 99 in: Sun T (2009). Atlas of hematologic neoplasms. Dordrecht New York: Springer. ISBN 978-0-387-89848-3. OCLC 432709321 ... Seiter K, Jules EH (20 May 2011). "Acute Myeloid Leukemia Staging". Retrieved 26 August 2011. Mihova D. "Leukemia acute - Acute ... Genetic abnormalities or the stage at which differentiation was halted form part of modern classification systems. Specific ...
Small-cell carcinoma
... termed limited stage (LS) and extensive stage (ES). The stage is generally determined by the presence or absence of metastases ... Small-cell carcinoma is an undifferentiated neoplasm composed of primitive-appearing cells. As the name implies, the cells in ... In limited-stage disease, relative 5-year survival rate (both sexes, all races, all ages) is 21.3%; however, women have higher ... Extensive stage small cell lung cancer is classified as a rare disorder. Ten-year relative survival rate is 3.5%; however, ...
Uveal melanoma
As seen in BRAF, mutations in GNAQ/GNA11 are early events in tumorigenesis and are not prognostic for tumor stage or later ... Kumar, Vinay (2009). "Uvea: Neoplasms". Robbins and Cotran Pathologic Basis of Disease, Professional Edition (8th ed.). ... "Classification and Stage Information for Intraocular (Uveal) Melanoma". National Cancer Institute. 1980-01-01. Retrieved 2013- ...
Grading (tumors)
Some pathology grading systems apply only to malignant neoplasms (cancer); others apply also to benign neoplasms. The ... TNM staging system (Other parameters) Tumor kinds that have their own grading system: Teratoma Gleason score Abrams, Gerald. " ... Grading in cancer is distinguished from staging, which is a measure of the extent to which the cancer has spread. Pathology ... The histologic tumor grade score along with the metastatic (whole-body-level cancer-spread) staging are used to evaluate each ...
Cervical cancer
Stage 1A cervical cancer Stage 1B cervical cancer Stage 2A cervical cancer Stage 2B cervical cancer Stage 3B cervical cancer ... Myung SK, Ju W, Kim SC, Kim H (October 2011). "Vitamin or antioxidant intake (or serum level) and risk of cervical neoplasm: a ... Due to the possible risk of cancer spread to the lymph nodes in stage 1B cancers and some stage 1A cancers, the surgeon may ... Survival rates decrease to 58% for women with stage III cancer and 17% or fewer of those with stage IV cancer five years after ...
Papillary carcinomas of the breast
A review of 10,485 individuals all of whom had early stage N1 (. 5 cm.) and axillary lymph node metastases (44.2% with no, 4.3 ... The World Health Organization (2019) classified papillary neoplasms (i.e. benign or cancerous tumors) of the breast into 5 ... Consequently, most studies have clinically staged and managed EPC tumors as in situ (i.e. neither invasive nor metastatic) ... Brogi E, Krystel-Whittemore M (January 2021). "Papillary neoplasms of the breast including upgrade rates and management of ...
Pseudomyxoma peritonei
Advanced stages may present as tumors palpable on the abdomen or distention of the belly ("jelly belly" is sometimes used as a ... For example, neoplasms characterized by high-grade features, invasive glands and or signet ring cells, are termed ... Young RH (May 2004). "Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms". Seminars in ... ISBN 978-0-323-35909-2. Sugarbaker PH (January 2006). "New standard of care for appendiceal epithelial neoplasms and ...
P16
However, p16 can be expressed in other neoplasms and in several normal human tissues. More than a third of urinary bladder SCCs ... In a retrospective trial analysis of patients with Stage III and IV oropharyngeal cancer, HPV status was assessed and it was ... p16 status is so prognostic that the AJCC staging system has been revised to include p16 status in oropharyngeal squamous cell ... 2017). "Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual". CA ...
Prostate cancer
The Whitmore-Jewett stage is another method. In men with high-risk localised prostate cancer, staging with PSMA PET/CT may be ... "Male Genitals - Prostate Neoplasms". Pathology study images. University of Virginia School of Medicine. Archived from the ... Knowing the stage helps define prognosis and is useful when selecting therapies. The most common system is the four-stage TNM ... Most combine stage, grade, and PSA level, and some include the number or percentage of biopsy cores positive, age, and/or other ...
Mir-708 microRNA precursor family
"Evaluation of microRNA expression profiles that may predict recurrence of localized stage I non-small cell lung cancer after ... "miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets ...
Primary effusion lymphoma
In this study, patients with advanced Ann Arbor Stage III or IV disease had a particularly poor survival rate at 1 year of 25 ... This lymphoma also belongs to a group of lymphoid neoplasms with plasmablastic differentiation that involve malignant ... Individuals diagnosed with PEL most commonly (>33% of all cases) present with advanced Stage III or IV disease. They are ... List of hematologic conditions Chen BJ, Chuang SS (March 2020). "Lymphoid Neoplasms With Plasmablastic Differentiation: A ...
Monica Baskin
Her father was diagnosed with eye neoplasm when she was a child, and ultimately lost his eye. Baskin has said that she ... Like many other African-Americans, her father was only diagnosed with cancer when he was at stage 4, which meant that death was ...
Mature T-cell lymphoma
Bone marrow biopsy is used to show the extent of disease, known as staging in pathology. The process takes about 10-15 minutes ... "The 2016 revision of the World Health Organization classification of lymphoid neoplasms". Blood. 127 (20): 2375-2390. doi: ... Mature T-cell lymphoma is fast-growing and patients are usually diagnosed at later stage. A majority of patients show advanced ... "Lymphoma Action , Tests, diagnosis and staging". Lymphoma Action. Retrieved 2020-04-26. "Peripheral T-Cell Lymphoma: Treatment ...
Dendritic cell
At certain development stages they grow branched projections, the dendrites that give the cell its name (δένδρον or déndron ... Blastic plasmacytoid dendritic cell neoplasm is a rare type of myeloid cancer in which malignant pDCs infiltrate the skin, bone ... Wang S, Wang X, Liu M, Bai O (April 2018). "Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel ... Blastic plasmacytoid dendritic cell neoplasm has a high rate of recurrence following initial treatments with various ...
Uterine adenosarcoma
The prognosis is determined primarily by the cancer stage. Most tumours are discovered at an early stage and have a good ... 2010). "Mullerian adenosarcoma of the uterus: a rare neoplasm with a need for onco-fertility". Eur J Gynaecol Oncol. 31 (6): ... Five-year survival for stage I and stage III tumours is approximately 80% and 50% respectively. Carcinosarcoma Sarcoma ...
CD79A
... the CD79a ITAM tyrosines synergize with the CD79b ITAM tyrosines to mediate the transition from the pro to the pre B cell stage ... and is also present in virtually all B-cell neoplasms, including B-cell lymphomas, plasmacytomas, and myelomas. It is also ...
Cancer
They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... Metastasis is common in the late stages of cancer and it can occur via the blood or the lymphatic system or both. The typical ... Metastasis is common in the late stages of cancer and it can occur via the blood or the lymphatic system or both. The typical ... People at all stages of cancer treatment typically receive some kind of palliative care. In some cases, medical specialty ...
Neprilysin
CD10+ differentiates mucinous cystic neoplasms (CD10+/CK20+) from intraductal papillary mucinous neoplasm of branch duct type ( ... Urothelial tumors express CD10 (42-67%). CD10 expression is strongly correlated with high tumor grade and stage in urothelial ... Murali R, Delprado W (2005). "CD10 immunohistochemical staining in urothelial neoplasms". Am. J. Clin. Pathol. 124 (3): 371-9. ... and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms". ...
Ubiquitin
Kales SC, Ryan PE, Nau MM, Lipkowitz S (June 2010). "Cbl and human myeloid neoplasms: the Cbl oncogene comes of age". Cancer ... Ubiquitin and ubiquitin-like molecules extensively regulate immune signal transduction pathways at virtually all stages, ... "DNA copy number losses in human neoplasms". The American Journal of Pathology. 155 (3): 683-94. doi:10.1016/S0002-9440(10)65166 ...
Ureteral cancer
There are multiple stages of ureteral cancer: 0, I, II, III, and IV. Stage 0 can be divided into stages 0a and 0is and occurs ... Ureteral neoplasm, a type of tumor that can be primary, or associated with a metastasis from another site Urethral cancer, ... Stage II is when the cancer spreads to the ureter muscle. Following Stage II is Stage III, characterized by the cancer ... Stage 0is (carcinoma in situ) is a flat tumor located on the tissue lining. Stage I is classified as cancer formation and the ...
VAMP regimen
McKay, Lorraine I.; Cidlowski, John A. (2003). "Corticosteroids in the Treatment of Neoplasms". {{cite journal}}: Cite journal ... early-stage Hodgkin's disease: results of a prospective clinical trial". J. Clin. Oncol. 20 (14): 3081-7. doi:10.1200/jco. ...
Chronic lymphocytic leukemia
Staging, determining the extent of the disease, is done with the Rai staging system or the Binet classification (see details) ... Hairy cell leukemia is also a neoplasm of B lymphocytes, but the neoplastic cells have a distinct morphology under the ... "staging systems" such as the Rai four-stage system and the Binet classification can help to determine when and how to treat the ... Early-stage disease does not need to be treated. CLL and SLL are considered the same underlying disease, just with different ...
H19 (gene)
In bladder cancers, H19 is also upregulated and present in most stages. The presence of H19 RNA was strongest in bladder ... In contrast to most other cancers, adrenocortical neoplasms appear to have decreased expression of H19. To determine a possible ... "Phase 1/2a Study of DTA-H19 in Advanced Stage Ovarian Cancer With Symptomatic Ascites". ClinicalTrials.gov. U.S. National ... adrenocortical neoplasms, choriocarcinomas, hepatocellular carcinomas, bladder cancers, ovarian serous epithelial cancers, head ...
Hyperinsulinemia
While hyperinsulinemia is often seen in people with early stage type 2 diabetes mellitus, it is not the cause of the condition ... Neoplasm Carbohydrate malabsorption Pancreatic cancer Polycystic ovary syndrome (PCOS) Trans fats Since hyperinsulinemia and ...
Periodontal disease
In its early stage, called gingivitis, the gums become swollen and red and may bleed. It is considered the main cause of tooth ... induced Genetic/developmental disorders Specific infections Inflammatory and immune conditions Reactive processes Neoplasms ... In the early stages, periodontitis has very few symptoms, and in many individuals the disease has progressed significantly ... "Staging and Grading Periodontitis" (PDF). Stambaugh RV, Dragoo M, Smith DM, Carasali L (1981). "The limits of subgingival ...
Radiation therapy
When Dupuytren's disease is at the nodules and cords stage or fingers are at a minimal deformation stage of less than 10 ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... Patient positioning is crucial at this stage as the patient will have to be placed in an identical position during each ... Radiation therapy is used to treat early stage Dupuytren's disease and Ledderhose disease. ...
List of skin conditions
... neoplasms, and cysts are skin lesions that develop from the epidermal layer of the skin. Aberrant basal cell carcinoma ... Eczema refers to a broad range of conditions that begin as spongiotic dermatitis and may progress to a lichenified stage. ... an overview with emphasis on the myeloid neoplasms". Chem. Biol. Interact. 184 (1-2): 16-20. doi:10.1016/j.cbi.2009.10.009. ... neoplasms invading or aberrantly present in the dermis. Acquired progressive lymphangioma (benign lymphangioendothelioma) Acral ...
Malignancy
Treatment during early stages is most effective. Forms of treatment include chemotherapy, surgery, photoradiation and ... Uses of "malignant" in oncology include: Malignancy, malignant neoplasm and malignant tumor are synonymous with cancer ... These include "prevention of cancer, diagnosis and staging of disease, disease cure, tumour debulking, symptom palliation and ... "Cancer data in Australia, cancer incidence and survival by stage data visualisation". Australian Institute of Health and ...
Nicolaus Copernicus University Ludwik Rydygier Collegium Medicum in Bydgoszcz
The instruction is organized according to the three stages of the European Higher Education Area (EHEA) : undergraduate studies ... In the 2000s, scientific research conducted by the institution focused on various domains: neoplasm, injury and their ... Neoplasms and Tuberculosis Department of Infectious Diseases and Hepatology Department of Dermatology and Venereology ...
Acute lymphoblastic leukemia
The subtypes of ALL as determined by immunophenotype and according to the stages of maturation. An extensive panel of ... May 2016). "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. ...
Siamese cat
The majority of deaths were caused by neoplasms, mainly mammary tumors. The Siamese also has a higher rate of morbidity. They ... the breed standard was setting the stage for the modern Siamese, with its call for a "dainty, long and svelte" body, a long ...
Papillary renal cell carcinoma
In advanced stages, hematuria, flank pain, and abdominal mass are the three classic manifestation. While a complete list of the ... Table 3 from: Weiss, Lawrence M.; Gelb, Arnold B.; Jeffrey Medeiros, L. (1995). "Adult Renal Epithelial Neoplasms". American ... Warren AY, Harrison D (December 2018). "WHO/ISUP classification, grading and pathological staging of renal cell carcinoma: ... of all kidney neoplasms. Based on its morphological features, PRCC can be classified into two main subtypes, which are type 1 ( ...
Browsing by Subject "Neoplasm Staging"
Listar por tema "Neoplasm Staging"
neoplasm staging | AI Blog
Real-World Data on Severe Lung Cancer
Neoplasm staging (IIIB and IIIC vs. IV). 1.10 (0.62, 1.94). 0.74. -. -. Genetic mutations (no vs. yes). 0.62 (0.41, 0.94). 0.03 ... Severe lung cancer is not necessarily end stage lung cancer. ○ Severe lung cancer and end stage lung cancer are two completely ... Endstage lung cancer is the critical stage of advanced lung cancer. ○ Endstage lung cancer is the critical stage of lung cancer ... Early-Stage and Locally Advanced Non-Small Cell Lung Cancer Management 1.25 CME / CE / ABIM MOC Credits ...
Multicenter phase 2 trial of nintedanib in advanced nonpancreatic neuroendocrine tumors
Benign and Malignant Soft-Tissue Tumors: Practice Essentials, Pathophysiology, Etiology
Staging of musculoskeletal neoplasms. Uhthoff HK, ed. Current Concepts of Diagnosis and Treatment of Bone and Soft Tissue ... Clinical stage is the most important predictor of clinical outcome. Clinical staging is done in accordance with the grade-tumor ... A comparison of staging systems for localized extremity soft tissue sarcoma. Cancer. 2000 Jun 15. 88 (12):2721-30. [QxMD ... Treatment of the patient with stage M0 soft tissue sarcoma. J Clin Oncol. 1988 May. 6 (5):854-62. [QxMD MEDLINE Link]. ...
Other Eye Disorders - Cancer and Neoplasms of the Eye | Vision and Eye Health Surveillance System (VEHSS) | Vision Health...
Category total - includes any clinical stage below.. Malignant neoplasm of the eye. Malignant neoplasm of the eye includes ... Benign neoplasm of the eye. Benign neoplasm of the eye includes diagnosis codes indicating benign neoplasm of the eye.. ... Cancer and neoplasms of the eye, any stage. ... Diagnosed cancer and neoplasms of the eye include a patient ... VEHSS identifies the annual prevalence of diagnosed Cancer and Neoplasms of the Eye based on the presence of International ...
Journal of Medical Internet Research - Automatically Detecting Failures in Natural Language Processing Tools for Online...
malignant neoplasm of breast staging. C2216702. Neoplastic process. "My friend was just diagnosed with Stage IV cancer". stage ... stage 2b. Stage 2B. C0441769. Classification. "I\m stage 4 SLL and stage 2 CLL". stage. Tumor stage. C1300072. Clinical ... Stage 1. Stage level 1. C0441766. Intellectual product. "Almost seven years ago I was diagnosed with stage 1 breast cancer at ... Stage. C1306673. Qualitative concept. "My mom was diagnosed 11/07 with stage IV inoperable EC". stage. Phase. C0205390. ...
Prevalence of pancreatic cystic lesions including intraductal papillary mucinous neoplasms in patients with end-stage renal...
Aiden Eliot Shearer, M.D. | Harvard Catalyst Profiles | Harvard Catalyst
Biblio | Page 4 | Linus Pauling Institute | Oregon State University
Multiple Myeloma | Myeloma | Multiple Myeloma Symptoms | MedlinePlus
Stages of Plasma Cell Neoplasms (Including Multiple Myeloma) (National Cancer Institute) Also in Spanish ... General Information about Plasma Cell Neoplasms (Including Multiple Myeloma) (National Cancer Institute) Also in Spanish ... Treatment Option Overview (Plasma Cell Neoplasms Including Multiple Myeloma) (National Cancer Institute) Also in Spanish ... Drugs Approved for Multiple Myeloma and Other Plasma Cell Neoplasms (National Cancer Institute) ...
Circulating Biomarkers and Resistance to Endocrine Therapy in Metastatic Breast Cancers: Correlative Results from AZD9496 Oral...
WHO EMRO | Effectiveness of breast cancer screening campaigns from 2012 to 2017 by analysis of stage at diagnosis, Lebanon |...
Keywords: breast cancer, neoplasm staging, hormone receptors, mammography, Lebanon. Citation: Elias F; Rabah H; Salih M; ... compared the trends of early stage breast cancer on diagnosis to advanced stage from 2012 to 2017, early stages of breast ... had stage II disease, 896 (27.0%) had stage III disease and 779 patients (23.5%) had stage IV disease (Table 2). About 35% of ... staging system, the most accepted classification (11). Stage at presentation was used for analysis. Clinical staging was used ...
Systematic Review of the Role of BCG in the Treatment of Urothelial Carcinoma of the Prostatic Urethra - Fingerprint
-...
HSR&D Citation Abstract
Invasive intraductal papillary mucinous neoplasm versus sporadic pancreatic adenocarcinoma: a stage-matched comparison of ... Invasive intraductal papillary mucinous neoplasm versus sporadic pancreatic adenocarcinoma: a stage-matched comparison of ... BACKGROUND: Although invasive intraductal papillary mucinous neoplasm (IPMN) of the pancreas is thought to be more indolent ... The authors compared survival and identify prognostic factors after resection for invasive IPMN versus stage-matched PAC. ...
Organ Preservation in Locally Advanced Rectal Cancer by Radiochemotherapy Followed by Consolidation Chemotherapy. - Full Text...
Rectal Cancer Rectal Neoplasms Rectal Cancer Stage II Rectal Cancer Stage III Radiation: Radiotherapy Drug: Chemotherapy Other ... Rectal Neoplasms. Colorectal Neoplasms. Intestinal Neoplasms. Gastrointestinal Neoplasms. Digestive System Neoplasms. Neoplasms ... Any MRI staged cT3 tumor or any cT1 cN+ or cT2 cN+ with nodal staging according to SOP MRI ... Pathological staging, tumor downstaging (assessed by ypTNM findings in relation to initial cTNM staging), tumor regression ...
Stanniocalcin 2 expression is associated with a favourable outcome in male breast cancer<...
... node staging, tumour size, ER, and PR status revealed that total STC2 expression as well as expression in tumour cells was an ... Male Breast Neoplasms Medicine & Life Sciences 85% * Breast Neoplasms Medicine & Life Sciences 21% ... node staging, tumour size, ER, and PR status revealed that total STC2 expression as well as expression in tumour cells was an ... node staging, tumour size, ER, and PR status revealed that total STC2 expression as well as expression in tumour cells was an ...
Recommendations for uniform definitions of surgical techniques for malignant pleural mesothelioma: a consensus report of the...
keywords = "Consensus, Humans, International Agencies, Lung Neoplasms/pathology, Mesothelioma/pathology, Neoplasm Staging, ... The International Staging Committee of the International Association for the Study of Lung Cancer and the International ... The International Staging Committee of the International Association for the Study of Lung Cancer and the International ... The International Staging Committee of the International Association for the Study of Lung Cancer and the International ...
Gabor Istvan Liposits - Research output
- University of Southern Denmark
Klinická stadia u nemocných s vícečetnými novotvary | Masaryk University
multiple neoplasms; clinical stages; Czech population Description. The results based in the Czech Cancer Registry in 1976-2005 ... The cancers of stage IV prevailed in males during the total period. The most of early stages were in Prague, of advanced stages ... of early clinical stages in males and 46.6 % in females, 9.3 % of advanced stages in males and 9.5 % in females. Unknown stages ... b) Of the 165,050 subsequent neoplasms (54.4 % males, 45.6 % females) - in cases following the primary stages I and II there ...
Approach to the Cancer Case: Staging--How and Why - WSAVA2008 - VIN
Clinical Staging of Small Animal Neoplasms. To stage tumours, we assess the size and extent of the:. Primary tumour (T) ... In some cases, the detectable tumour stage does not reflect the true stage, because of the limitations of the techniques ... Using this classification, worsening survival has been reported with advancing stage for dogs with oral tumours (White et al, ... The immunological response seen in reactive nodes may be important in the early stages in slowing down metastases. However, ...
Locoregional management of hepatocellular carcinoma: Surgical and ablation therapies - Fingerprint - Mayo Clinic
An Update on Gastroenteropancreatic Neuroendocrine Tumors
TNM staging of neoplasms of the endocrine pancreas: results from a large international cohort study. J Natl Cancer Inst. 2012; ... for stage I and II tumors vs 91% for stage III (locoregionally advanced) and 73% for stage IV tumors. Although the ENETS TNM ... TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Arch. ... TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch. 2006;449:395- ...
Surveillance, Epidemiology, And End Results, 1973-1989
27 Historic Stage. Historic Stage ITEM NUMBER/NAME: 27 Historic Stage LENGTH: 1 FIELD 0 In situ A noninvasive neoplasm; a tumor ... 4 Distant A neoplasm that has spread to parts of the body remote from the primary tumor either by direct extension or by ... 2 Regional A neoplasm that has extended 1) beyond the limits of the organ of origin directly into surrounding organs or tissues ... Registers all in situ and malignant neoplasms with the exception of certain histologies for cancer of the skin. Records data on ...
The ENETS TNM staging and grading system accurately predict prognosis in patients with rectal NENs<...
Neoplasm Staging Medicine & Life Sciences 85% * Multicenter Studies Medicine & Life Sciences 34% ... The ENETS TNM staging and grading system accurately predict prognosis in patients with rectal NENs. Digestive and Liver Disease ... The ENETS TNM staging and grading system accurately predict prognosis in patients with rectal NENs. In: Digestive and Liver ... The 5-year OS and PFS were 79.5% and 65.2%. Stage IV and G3 were associated with worse OS (HR 8.16; p = 0.002; HR 15.57; p = ...
Search Results
SciELO - Brazil - PROGNOSTIC FACTORS AND SURVIVAL ANALYSIS IN ESOPHAGEAL CARCINOMA PROGNOSTIC FACTORS AND SURVIVAL ANALYSIS IN...
Factors associated to neoplasm High tumor size and high oncologic stage was associated with high mortality in SCC. This is in ... Longitudinal neoplasm extension at diagnosis was compared to clinical oncologic stage. By Chi-square analysis, it was noted ... factors associated to neoplasm (tumor size, tumor location, grade of cellular differentiation, stage of cancer); and factors ... Degree of cellular differentiation was related to poor clinical stage in SCC (Chi-Sq=27.831; DF=6; p-value=0.00), but not in EA ...
Publications
Laparoscopic ultrasound enhances diagnostic laparoscopy in the staging of intra-abdominal neoplasms. Am Surg. 2000 Apr; 66(4): ... Two-Staged Implant-Based Breast Reconstruction: A Long-Term Outcome Study in a Young Population. Medicina (Kaunas). 2019 Aug 14 ... A Phase II Trial of Neoadjuvant MK-2206, an AKT Inhibitor, with Anastrozole in Clinical Stage II or III PIK3CA-Mutant ER- ... Survival of cutaneous melanoma based on sex, age, and stage in the United States, 1992-2011. Cancer Med. 2017 Oct; 6(10):2203- ...
PrognosisSecond Primary NeoplasmsDiagnosisTumorsPathologyLymph NodesClinicalIncidenceTumourHeterogeneousClassificationMyeloproliferativeMucinous neoplasmsMalignant NeoplasmsIntraductal papillaryAbnormal growth of cellsCarcinomaCancer StagingDiffuse neuroendocrine systemBenignMortalityPrevalenceSurvival RateEsophagealPrognostic factorsLung cancerRecurrencePancreatic-cancerColorectal cancerResectionRegistriesGrading2022Different stagesEarly stagesMultivariate AnalysisMyeloidRenalSurgicalCancersAmerican JointSymptomsPatientsPrimaryAccurately
Prognosis5
- [ 1 ] Two-thirds of patients with lung cancer are diagnosed with stage IIIB, IIIC, and IV, and the prognosis of these patients is clinically poor. (medscape.com)
- For individual patients, factors other than clinical staging are also important in determining treatment and prognosis: for example, the presence of paraneoplastic syndromes or significant intercurrent disease. (vin.com)
- Conclusion: Both staging and grading accurately predict rectal NENs prognosis. (elsevier.com)
- Both NETs and neuroendocrine carcinomas are also further classified according to the TNM staging system of the European Neuroendocrine Tumor Society and the American Joint Committee on Cancer/Union for International Cancer Control, to stratify them regarding prognosis ( 5 ). (snmjournals.org)
- Previous studies had reported that high 18 F-FDG uptake is usually associated with more aggressive GEPs and a less benign prognosis, whereas higher uptake of 68 Ga-DOTATATE is characteristic of low-grade neoplasms versus high-grade ones ( 8 , 9 ). (snmjournals.org)
Second Primary Neoplasms1
- Within the Cancer Risk in Childhood Cancer Survivors (CRICCS) study we aimed to assess the ability of registries to collect data needed to conduct comparative studies of childhood cancer prevalence and risk of second primary neoplasms among survivors of childhood cancer. (who.int)
Diagnosis19
- Diagnosed cancer and neoplasms of the eye include a patient having one or more diagnosis codes indicating one or more of the subgroups listed below. (cdc.gov)
- Malignant neoplasm of the eye includes diagnosis codes indicating malignant neoplasm of the eye or carcinoma in situ of the eye. (cdc.gov)
- Benign neoplasm of the eye includes diagnosis codes indicating benign neoplasm of the eye. (cdc.gov)
- This study aimed to assess the effect of mammography screening campaigns in reducing the breast cancer stage at diagnosis. (who.int)
- Demographic and pathology characteristics, cancer stage at diagnosis and presence of receptors were extracted and analysed. (who.int)
- Advanced stage at diagnosis was common outside Beirut (60.4% in Bekaa and 54.7% in North Lebanon). (who.int)
- METHODS: A web-based survey was administered to surgeons who operated on malignant pleural mesothelioma (MPM) for diagnosis, staging, palliation, or cytoreduction. (edu.au)
- They were divided according to histological diagnosis (444 squamous cell carcinoma patients and 105 adenocarcinoma), and their demographic, pathological and clinical characteristics were analyzed and compared to clinical stage and overall survival. (scielo.br)
- Weight loss (kg), BMI variation (kg/m²) and percentage of weight loss are factors that predict worse stage at diagnosis in the squamous cell carcinoma. (scielo.br)
- Went in for removal of Intraductal Papillary Mucinous Neoplasm, came out with Stage IIA pancreatic cancer diagnosis. (mayoclinic.org)
- Objective: To evaluate the effect of irregular screening behaviour on the risk of advanced stage breast cancer at diagnosis in Flanders. (rug.nl)
- The association between screening regularity and breast cancer stage at diagnosis was evaluated in multivariable logistic regression models, taking age of diagnosis and socio-economic status into account. (rug.nl)
- abstract = "Objective: To evaluate the effect of irregular screening behaviour on the risk of advanced stage breast cancer at diagnosis in Flanders.Methods: All women aged 50-69 who were invited to the organized breast cancer screening and diagnosed with breast cancer before age 72 from 2001 to 2018 were included. (rug.nl)
- The association between screening regularity and breast cancer stage at diagnosis was evaluated in multivariable logistic regression models, taking age of diagnosis and socio-economic status into account.Results: In total 13.5% of the 38,005 breast cancer cases were diagnosed at the advanced stage. (rug.nl)
- All of them were interviewed and evaluated by the Hospital Anxiety and Depression Scale at different stages: Post-diagnosis (n= 9), post-surgical (n= 8) and chemotherapy (n= 10). (bvsalud.org)
- Late-stage presentation and inaccessible diagnosis and treatment are common. (who.int)
- Socioeconomic status, access to care, risk factor patterns, and stage at diagnosis for head and neck cancer among black and white patients. (who.int)
- EUS has an integral role in the diagnosis of pancreatic cancer given its high sensitivity for detecting pancreatic neoplasms and the access it affords to perform fine needle aspiration (FNA) of the suspected lesions. (abdominalkey.com)
- Soriano and colleageus compared the accuracy of CT, MRI, and EUS in assessing TNM staging of pancreatic cancer using surgical diagnosis as the gold standard. (abdominalkey.com)
Tumors7
- Soft-tissue tumors constitute a large and heterogeneous group of neoplasms. (medscape.com)
- Most soft-tissue tumors respect fascial boundaries, remaining confined to the compartment of origin until the later stages of development. (medscape.com)
- There were uncommon the number of 12,418 subsequent tumors of advanced stages in men (13.8 % of total 89,796 subsequent ones) and 10,189 in women (13.5 % of total 75,254 subsequent ones), following the primary cancers of stages III, IV. (muni.cz)
- Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of neoplasms arising from the diffuse neuroendocrine system. (cancernetwork.com)
- Pseudomyxoma peritonei (PMP) is a rare disease arising from primary mucinous tumors, which are usually appendiceal mucinous epithelial neoplasms and rarely mucinous ovarian tumors [1] . (cureus.com)
- Studies using both radiography and sputum cytology have shown that more lung cancers are discovered in screened populations, that screen detected neoplasms have a larger shift to early stage tumors, and that case survival increases in screen detected malignancies. (cdc.gov)
- TNM staging of pancreatic tumors by EUS is feasible and accurate. (abdominalkey.com)
Pathology1
- The peritoneal cancer while pregnant cancer while pregnant peritoneal cancer neoplasm of gynecological pathology was seen in women with polycystic ovaries i. (anvelope-janteauto.ro)
Lymph Nodes2
- In contrast, the remaining Kaposi sarcoma forms affect lymph nodes, mucosa, and visceral organs at early stages, progress rapidly, and encompass symptoms in the hard palate and oral mucosa ( 6 , 7 ). (cdc.gov)
- Even if at initial stages a tumour does not seem aggressive, its central location in proximity with several other organs makes it very dangerous: the most common metastases are in the lymph nodes and in the lungs (55%), liver and bones (33%), followed by the other kidney, the brain, the spleen, the colon and the skin. (lugnani.com)
Clinical16
- Category total - includes any clinical stage below. (cdc.gov)
- The results based in the Czech Cancer Registry in 1976-2005: a) Of the 125,262 primary neoplasms (52.1 % males, 47.9 % females) there were registered 37.1 % of early clinical stages in males and 46.6 % in females, 9.3 % of advanced stages in males and 9.5 % in females. (muni.cz)
- It is worrying that of total multiple cases every the seventh gastrointestinal cancer in males and the fifth in females were detected at any advanced clinical stages after primary cancer. (muni.cz)
- The results can be suggested to list the multiple neoplasms and their clinical stages in the annual statistical reports of cancers in the Czech population. (muni.cz)
- The World Health Organisation (Owen, 1980) has published guidelines for the clinical staging of many animal tumours. (vin.com)
- In some cases, the detectable tumour stage does not reflect the true stage, because of the limitations of the techniques available in assessing the extent of the disease, e.g., even in the absence of detectable metastatic disease, all cases of long bone osteosarcoma are assumed to have metastatic spread at first presentation and are treated as having disease at a more advanced stage than clinical staging indicates. (vin.com)
- They are a heterogeneous group of neoplasms with varying clinical expressions, presenting as either functioning or nonfunctioning, with an indolent clinical course in most patients. (snmjournals.org)
- Accurate staging using the American Joint Committee on Cancer/International Union Against Cancer (AJCC/UICC) TNM system is essential for patient management, and has been reinforced by clinical evidence in recent years. (nature.com)
- Aim: To correlate the blood levels of Lipid Peroxidation (LPO), Reduced Glutathione (GSH), Superoxide Dismutase (SOD), and Vitamin A and E levels with the clinical stage in Ca Cx. (who.int)
- EMR has taken a central role, as it allows the pathologist to provide tumor-staging information necessary for an appropriate clinical management decision process. (elsevier.com)
- NCCN Clinical Practice Guidelines in Oncology: Uterine Neoplasms. (medscape.com)
- Les résultats ont été évalués en utilisant le score d'interprétation de l'American Society of Clinical Oncology (l'ASCO), basé sur le pourcentage de cellules marquées, et l'intensité du marquage dans la perspective d'un traitement par le Trastuzumab (Herceptine). (bvsalud.org)
- The phase I clinical trial of Procaspase Activating Compound-1 (PAC-1), a drug that spurs programmed cell death in cancer cells, found only minor side effects in patients with end-stage cancers. (ronnyallan.net)
- Multiple genetic loci modulate lung adenocarcinoma clinical staging. (cdc.gov)
- Although a detailed discussion of the overlap neoplasms is beyond the scope of this review, they share clinical, pathologic, and therapeutic features with MDS and can be treated similarly when they present with more features of MDS than MPN. (medscape.com)
- In the quantitative stage, we applied an instrument on changes in life after intestinal stomization, with clinical and (CE)/adjuvants equipment-related evaluation with 204 intestinal ostomized people. (bvsalud.org)
Incidence3
- The incidence of poor PS is high among patients in all stages of lung cancer. (medscape.com)
- The survival rate at five years of folow-up shows a higher incidence peritoneal cancer age peritoneal cancer peritoneal cancer neoplasm stage in patients under 30 years old, probably due to the earlier stages detected. (anvelope-janteauto.ro)
- Interestingly, the incidence of pancreatic endocrine neoplasms increased over the same time periods by 106% in men and 125% in women. (abdominalkey.com)
Tumour2
- Size alone has limited accuracy as 26% of patients with stage IV and 16% with G3 have a primary tumour≤10 mm. (elsevier.com)
- The terms 'neoplasm' and 'tumour' are used interchangeably. (who.int)
Heterogeneous1
- [ 2 ] This classification of myeloid neoplasms also includes a collection of heterogeneous neoplasms that share features of MDS and myeloproliferative neoplasms. (medscape.com)
Classification4
- VEHSS identifies the annual prevalence of diagnosed Cancer and Neoplasms of the Eye based on the presence of International Classification of Diseases (ICD)-9 and ICD-10 codes in patient claims or electronic health record (EHR) systems. (cdc.gov)
- Significant progress has been made in the standardization of bladder neoplasm classification and reporting. (nature.com)
- All patients were classified according to the classification of the American Joint Committee for Cancer Staging and End-Results Reporting (AJC) and to that of the International Union Against Cancer (UICC, Geneva, 1978). (unimi.it)
- As such, in 2022, the World Health Organization (WHO) updated its classification of myelodysplastic syndromes, replacing the term "syndromes" with "neoplasms" to reflect the neoplastic biology of these diseases. (medscape.com)
Myeloproliferative5
- The MPN Research Foundation has a single goal: to stimulate original research in pursuit of new treatments - and eventually a cure - for polycythemia vera,essential thrombocythemia and myelofibrosis, known collectively as myeloproliferative neoplasms (MPNs). (mpnfoundation.org)
- What are myeloproliferative neoplasms (MPNs)? (voicesofmpn.com)
- Myeloproliferative neoplasms (MY-ah-lo-pro-LIF-er-uh-tiv NEE-o-plaz-uhms), or MPNs, are a group of rare, chronic blood cancers in which a person's bone marrow does not function properly. (voicesofmpn.com)
- Once known as myeloproliferative disorders (MPDs), myeloproliferative neoplasms were renamed and officially classified as cancers of the bone marrow in 2008 by the World Health Organization. (voicesofmpn.com)
- Myeloproliferative neoplasms, or MPNs, are a group of rare, chronic blood cancers in which a person's bone marrow does not function properly. (voicesofmpn.com)
Mucinous neoplasms1
- Pseudomyxoma peritonei (PMP) is a rare manifestation of primary mucinous neoplasms. (cureus.com)
Malignant Neoplasms2
- The death of ESPN sportscaster Stuart Scott has generated interest in cancer deaths in the U.S. Cancer is the second leading cause of death in the U.S. The number of cancer deaths are available from the multiple cause of death option on the CDC WONDER database using the C00-C97 ICD Code, "Malignant Neoplasms. (cdc.gov)
- Malignant neoplasms of the kidney can originate from different types of tissue. (krebsdaten.de)
Intraductal papillary5
- Invasive intraductal papillary mucinous neoplasm versus sporadic pancreatic adenocarcinoma: a stage-matched comparison of outcomes. (va.gov)
- BACKGROUND: Although invasive intraductal papillary mucinous neoplasm (IPMN) of the pancreas is thought to be more indolent than sporadic pancreatic adenocarcinoma (PAC), the natural history remains poorly defined. (va.gov)
- If you are comfortable sharing more, did your husband have symptoms that led to the removal of the Intraductal Papillary Mucinous Neoplasm? (mayoclinic.org)
- Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is. (biogps.org)
- Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is a precursor lesion of pancreatic cancer and progresses according to adenoma-carcinoma sequence. (biogps.org)
Abnormal growth of cells2
- Simply explained, malignant neoplasm or cancer is the uncontrollable, abnormal growth of cells within the human body. (allhealthpost.com)
- A neoplasm is an abnormal growth of cells that are produced when there is more cell division than normal or when cells do not die when they are supposed to. (voicesofmpn.com)
Carcinoma3
- In patients with squamous cell carcinoma, poor differentiation histology and tumor size were associated with worse oncology stage, but this was not evidenced in adenocarcinoma. (scielo.br)
- Background: Free radical Injury is associated with cancer, but how the extent of oxidative stress correlates with the FIGO (International Federation of Gynecology and Obstetrics) stage in Carcinoma Cervix (Ca Cx), and its significance as a prognostic marker, is not clear and needs an in-depth study. (who.int)
- Constantin: Detalii noutati Peritoneal cancer age Peritoneal cancer neoplasm ovarian serous carcinoma in a young woman - case report and literature review Peritoneal cancer age Peritoneal cancer end stage. (anvelope-janteauto.ro)
Cancer Staging4
- However, it still lacks information on cancer staging and mortality. (who.int)
- A cogent and comprehensive pathologic report is essential for optimal patient management, cancer staging, and prognostication. (stanford.edu)
- A summary and discussion of the updated vulval cancer staging system by the International Federation of Obstetricians and Gynaecologists (FIGO) in 2021 is also provided. (stanford.edu)
- The relation of breast cancer staging to screening protocol compliance: a computer simulation study. (omeka.net)
Diffuse neuroendocrine system1
- Gastroenteropancreatic neuroendocrine neoplasms (GEPs) arise from the diffuse neuroendocrine system. (snmjournals.org)
Benign1
- the induction of benign neoplasms may in some circumstances (see Section 9) contribute to the judgement that the exposure is carcinogenic. (who.int)
Mortality2
Prevalence2
- Most of the patients with malignant disease were multiparous Moreover, from menopausal patients, the higher prevalence was seen at the group between 45 and 55 years old, not being peritoneal cancer neoplasm on the earlier appearance. (anvelope-janteauto.ro)
- To describe the prevalence of inadequate nutritional status of children and adolescents with malignant neoplasm at hospital admission in childhood cancer reference centers in Brazil. (bvsalud.org)
Survival Rate1
- Furthermore, the surgical treatment by TNM stages was achieved, measuring the survival rate after five years of follow-up. (anvelope-janteauto.ro)
Esophageal1
- To safely employ these techniques, reliable and accurate staging of the esophageal neoplasm is essential. (elsevier.com)
Prognostic factors3
- This gap in knowledge prevents a precise evaluation of the effectiveness of screening campaigns, particularly as the stage of cancer at presentation is one of the most important prognostic factors of survival (10). (who.int)
- The authors compared survival and identify prognostic factors after resection for invasive IPMN versus stage-matched PAC. (va.gov)
- Tumor grading and staging represent the main prognostic factors of these neoplasms. (snmjournals.org)
Lung cancer3
- Severe lung cancer patients were mainly stage IV elderly male patients without gene mutation and a history of resection. (medscape.com)
- The International Staging Committee of the International Association for the Study of Lung Cancer and the International Mesothelioma Interest Group recommend that P/D should aim to remove all macroscopic tumor involving the parietal and visceral pleura and should be termed "extended" P/D when the diaphragm or pericardium is resected. (edu.au)
- To the best of our knowledge, synchronous extensive‑stage small cell lung cancer (ES‑SCLC) and MCLBMI have not been previously reported. (spandidos-publications.com)
Recurrence1
- Survival from time of recurrence was assessed based on Memorial Sloan-Kettering Cancer Center risk score, symptoms at recurrence, metastasectomy, tumor diameter, and recurrence stage and site. (elsevier.com)
Pancreatic-cancer2
- I am sure that one of our members will respond to your questions about their experiences with treatment, I did find some information on the American Cancer Society's website regarding the staging of pancreatic cancer which you may find interesting. (mayoclinic.org)
- It is worth stressing that, although CT is more accurate in assessing T-staging of pancreatic cancer, EUS is still more sensitive and accurate in pancreatic lesions less than 3 cm in size. (abdominalkey.com)
Colorectal cancer3
- We assessed levels of clusterin expression in a group of stage II colorectal cancer patients to assess its utility as a prognostic marker. (lenus.ie)
- The study included 251 patients with stage II colorectal cancer. (lenus.ie)
- Clusterin levels are associated with poor survival in stage II colorectal cancer. (lenus.ie)
Resection1
- Primary carcinomas of the vagina are uncommon and currently detailed recommendations for the reporting of resection specimens of these neoplasms are not widely available. (stanford.edu)
Registries3
- Among 141 registries, subsequent primary neoplasms were recorded in 135 (96%) and follow-up data in 113 of them. (who.int)
- Stage was collected in 112 (79%) registries, treatment in 75 (53%) and predisposing characteristics in 18 (13%) registries. (who.int)
- Information on both stage and treatment was collected in 72 (51%) registries, however only 15 (11%) collected information on stage, treatment, and predisposing characteristics. (who.int)
Grading1
- Aim: To evaluate the prognostic role of the ENETs staging and grading systems in rectal NENs. (elsevier.com)
20221
- September 19, 2022) A Case Report of Pseudomyxoma Peritonei Arising From Primary Mucinous Ovarian Neoplasms. (cureus.com)
Different stages6
- It proceeds through different stages starting from early embryonic life-mesoblastic stage (yolk sac), hepatic stage, and myeloid (bone marrow) stage. (jaypeedigital.com)
- IMSEAR at SEARO: Lipid peroxidation and antioxidants in different stages of cervical cancer: Prognostic significance. (who.int)
- Srivastava S, Natu S M, Gupta A, Pal K A, Singh U, Agarwal G G, Singh Uma, Goel M M, Srivastava A N. Lipid peroxidation and antioxidants in different stages of cervical cancer: Prognostic significance. (who.int)
- Statistical Analysis: The cases and controls were compared using One Way ANOVA and different stages over different time periods were individually compared by Repeated Measure Analysis of Variance. (who.int)
- Some epidemiological and experimental studies indicate that different agents may act at different stages in the carcinogenic process, and several different mechanisms may be involved. (who.int)
- In order to determine molecules affecting intraepithelial DC infiltration in IPMNs during multistep carcinogenesis, we examined the gene-expression profiles of entire transcripts of neoplastic cells at different stages. (biogps.org)
Early stages6
- The most of early stages were in Prague, of advanced stages in Pilsen region. (muni.cz)
- Of other 10,292 multiplicities there were16.2 % of early stages in males and 11.7 % in females, 1.6 % of advanced stages in males and 1.2 % in females. (muni.cz)
- c) Of 41,161 survived up to October 2007 there were 54.7 % of early stages in males and 58 % in females, 5 % of advanced stages in males and 5.2 % in females, unknown stages 40.3 % in males and 36.9 % in females. (muni.cz)
- Of 84,101 deaths there were 30 % of early stages in males and 39.8 % in females, 11 % of advanced stages in males and 12.1 % in females, unknown stages 59 % in males and 48.1 % in females. (muni.cz)
- However, in case of critical cancers like brain cancer, the symptoms may start exhibiting at the very early stages. (allhealthpost.com)
- Precancerous diseases and the early stages of cervix uteri] / L. N. Vasilevskaya, M. L. Vinokur, N. I. Nikitina. (who.int)
Multivariate Analysis1
- In a multivariate analysis, stage C disease and high beta2 microglobulin were independent predictors of a positive DAT result. (ox.ac.uk)
Myeloid3
- Red cells, granulocytes, monocytes, and platelets are derived from myeloid stem cell while B and T lymphocytes are formed from lymphoid stem cell through intermediate stages. (jaypeedigital.com)
- Myelodysplastic syndromes (MDS) are a group of clonal myeloid neoplasms characterized by ineffective hematopoiesis that present clinically as cytopenia(s), dysplasia in one or more hematopoietic cell lines in the bone marrow, and risk of transformation to acute myeloid leukemia (AML). (medscape.com)
- However, with ever-increasing knowledge of the biology and molecular heterogeneity of myeloid neoplasms comes the ability to further classify MDS with prognostic and predictive relevance. (medscape.com)
Renal2
- If patients with severe renal impairment or end-stage renal disease (ESRD) receiving SELZENTRY (without concomitant CYP3A inducers or inhibitors) experience postural hypotension the SELZENTRY dose should be reduced from 300 mg twice daily to 150 mg twice daily ( 5.2 ). (nih.gov)
- Generally, kidney tumours originate from the proliferation of malignant cells within the renal tubules (or nephrons), or they are neoplasms from the fibrous tissues (that cover the organ itself). (lugnani.com)
Surgical2
- Should a positive surgical margin following radical prostatectomy be pathological stage T2 or T3? (elsevier.com)
- Dive into the research topics of 'Should a positive surgical margin following radical prostatectomy be pathological stage T2 or T3? (elsevier.com)
Cancers3
- The cancers of stage IV prevailed in males during the total period. (muni.cz)
- Between these subsequent and advanced stages predominated - in males 36.9 % cancers of gastrointestinal and 33.1 % respiratory tract, 10.3 % genital organs, 8.1 % urinary tract, - in females 37 % cancers of gastrointestinum, 21 % breast, 17.2 % genital organs, 12.8 % respiratory and 4.5 % urinary tract. (muni.cz)
- High clusterin expression correlates with a poor outcome in stage II colorectal cancers. (lenus.ie)
American Joint2
- 7 , 8 The 2002 revision of the American Joint Committee on Cancer/International Union Against Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM system is the most widely used staging system at this time ( Table 1 ). (nature.com)
- Antigenics, Inc, Woburn, MA) in metastatic (American Joint Committee on Cancer stage IV) melanoma patients. (elsevier.com)
Symptoms3
- Unlike other ailments, the symptoms or indicative signs of cancer vary widely depending on a variety of factors like the cancer type, cancer stage, etc. (allhealthpost.com)
- Not only that, the symptoms vary from individual to individual and may also be totally absent until cancer has reached a very advanced stage. (allhealthpost.com)
- Though several symptoms are cancer-type specific, yet an uncontrolled growth of cells leads to certain common problems that may be considered as the typical cancer symptoms which may be indicative of malignant neoplasm. (allhealthpost.com)
Patients4
- Results: Of 100 patients (mean age 55, 45% male, mean size 16.2 mm) 62, 5, 10 and 23 were TNM stage 1 to 4, and 63, 15 and 22 were G1, G2 and G3. (elsevier.com)
- Can PET/CT Guide the Personalized Treatment of Patients with Gastroenteropancreatic Neuroendocrine Neoplasms? (snmjournals.org)
- 8 ), in studying a group of 38 patients with neuroendocrine neoplasms, including 28 GEPs, found that 3 patients lacked uptake of both 68 Ga-DOTATATE and 18 F-FDG (1 G1, 1 G2, and 1 G3). (snmjournals.org)
- Stage IIIB or IV NSCLC patients diagnosed from 2011 to 2013 at Seoul National University Hospital (cohort 1) were reviewed. (ecologicalsgardens.com)
Primary1
- We report two rare cases of PMP originating from mucinous primary ovarian neoplasms. (cureus.com)
Accurately1
- Accurately staging. (myesr.org)