Argon. A noble gas with the atomic symbol Ar, atomic number 18, and atomic weight 39.948. It is used in fluorescent tubes and wherever an inert atmosphere is desired and nitrogen cannot be used.
A method of tissue ablation and bleeding control that uses ARGON plasma (ionized argon gas) to deliver a current of thermocoagulating energy to the area of tissue to be coagulated.
Procedures using an electrically heated wire or scalpel to treat hemorrhage (e.g., bleeding ulcers) and to ablate tumors, mucosal lesions, and refractory arrhythmias. It is different from ELECTROSURGERY which is used more for cutting tissue than destroying and in which the patient is part of the electric circuit.
Introduction of substances into the body using a needle and syringe.
That portion of the electromagnetic spectrum from the UHF (ultrahigh frequency) radio waves and extending into the INFRARED RAYS frequencies.
Endoscopes for examining the interior of the uterus.
A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.
Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.
Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.
Pathological processes of the UTERINE CERVIX.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
Tumors or cancer of the UTERINE CERVIX.
Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.
Individuals licensed to practice medicine.
Prospective patient listings for appointments or treatments.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Those physicians who have completed the education requirements specified by the American Academy of Family Physicians.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Excision of all or part of the liver. (Dorland, 28th ed)
Tumors or cancer of the LIVER.
A benign epithelial tumor of the LIVER.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The transference of a part of or an entire liver from one human or animal to another.
Tumors or cancer of the NASOPHARYNX.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Tumors or cancer of the RECTUM.
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most commonly by a THROMBUS or EMBOLUS.
Disease having a short and relatively severe course.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.
A benign tumor composed of fat cells (ADIPOCYTES). It can be surrounded by a thin layer of connective tissue (encapsulated), or diffuse without the capsule.
A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.

Intrahepatic recurrence after curative resection of hepatocellular carcinoma: long-term results of treatment and prognostic factors. (1/9672)

OBJECTIVE: This study aimed to evaluate the long-term results of treatment and prognostic factors in patients with intrahepatic recurrence after curative resection of hepatocellular carcinoma (HCC). SUMMARY BACKGROUND DATA: Recent studies have demonstrated the usefulness of re-resection, transarterial oily chemoembolization (TOCE), or percutaneous ethanol injection therapy (PEIT) in selected patients with intrahepatic recurrent HCC. The overall results of a treatment strategy combining these modalities have not been fully evaluated, and the prognostic factors determining survival in these patients remain to be clarified. METHODS: Two hundred and forty-four patients who underwent curative resection for HCC were followed for intrahepatic recurrence, which was treated aggressively with a strategy including different modalities. Survival results after recurrence and from initial hepatectomy were analyzed, and prognostic factors were determined by univariate and multivariate analysis using 27 clinicopathologic variables. RESULTS: One hundred and five patients (43%) with intrahepatic recurrence were treated with re-resection (11), TOCE (71), PEIT (6), systemic chemotherapy (8) or conservatively (9). The overall 1-year, 3-year, and 5-year survival rates from the time of recurrence were 65.5%, 34.9%, and 19.7%, respectively, and from the time of initial hepatectomy were 78.4%, 47.2%, and 30.9%, respectively. The re-resection group had the best survival, followed by the TOCE group. Multivariate analysis revealed Child's B or C grading, serum albumin < or = 40 g/l, multiple recurrent tumors, recurrence < or = 1 year after hepatectomy, and concurrent extrahepatic recurrence to be independent adverse prognostic factors. CONCLUSIONS: Aggressive treatment with a multimodality strategy could result in prolonged survival in patients with intrahepatic recurrence after curative resection for HCC. Prognosis was determined by the liver function status, interval to recurrence, number of recurrent tumors, any concurrent extrahepatic recurrence, and type of treatment.  (+info)

Surgery-related factors and local recurrence of Wilms tumor in National Wilms Tumor Study 4. (2/9672)

OBJECTIVE: To assess the prognostic factors for local recurrence in Wilms tumor. SUMMARY BACKGROUND DATA: Current therapy for Wilms tumor has evolved through four studies of the National Wilms Tumor Study Group. As adverse prognostic factors were identified, treatment of children with Wilms tumor has been tailored based on these factors. Two-year relapse-free survival of children in the fourth study (NWTS-4) exceeded 91%. Factors once of prognostic import for local recurrence may lose their significance as more effective therapeutic regimens are devised. METHODS: Children evaluated were drawn from the records of NWTS-4. A total of 2482 randomized or followed patients were identified. Local recurrence, defined as recurrence in the original tumor bed, retroperitoneum, or within the abdominal cavity or pelvis, occurred in 100 children. Using a nested case-control study design, 182 matched controls were selected. Factors were analyzed for their association with local failure. Relative risks and 95% confidence intervals were calculated, taking into account the matching. RESULTS: The largest relative risks for local recurrence were observed in patients with stage III disease, those with unfavorable histology (especially diffuse anaplasia), and those reported to have tumor spillage during surgery. Multiple regression analysis adjusting for the combined effects of histology, lymph node involvement, and age revealed that tumor spillage remained significant. The relative risk of local recurrence from spill was largest in children with stage II disease. The absence of lymph node biopsy was also associated with an increased relative risk of recurrence, which was largest in children with stage I disease. The survival of children after local recurrence is poor, with an average survival rate at 2 years after relapse of 43%. Survival was dependent on initial stage: those who received more therapy before relapse had a worse prognosis. CONCLUSIONS: This study has demonstrated that surgical rupture of the tumor must be prevented by the surgeon, because spills produce an increased risk of local relapse. Both local and diffuse spills produce this risk. Stage II children with local spill appear to require more aggressive therapy than that used in NWTS-4. The continued critical importance of lymph node sampling in conjunction with nephrectomy for Wilms tumor is also established. Absence of lymph node biopsy may result in understaging and inadequate treatment of the child and may produce an increased risk of local recurrence.  (+info)

Second-line treatment for primary central nervous system lymphoma. (3/9672)

Failure after first-line treatment was reported in 35-60% of immunocompetent patients with primary central nervous system lymphoma (PCNSL). There are currently no reports focusing on salvage therapy. This review analyses prognostic factors and the efficacy of salvage therapy by focusing on data from papers reporting results of first-line treatment in 355 cases. The study group consisted of 173 patients presenting treatment failure. The interval between failure and death (TTD) was compared for age at relapse (< or =60 vs. >60 years), type of failure (relapse vs. progression), time to relapse (< or =12 vs. >12 months) and salvage treatment (yes vs no). Median TTD was similar in younger and older patients (P = 0.09). Relapsed patients had a longer TTD than patients with progressive disease (P = 0.002). Early relapse led to a shorter TTD than late relapse (P = 0.005). Median TTD was 14 months for patients who underwent salvage therapy and 2 months for untreated cases (P<0.00001). A multivariate analysis showed an independent prognostic role for salvage therapy and time to relapse. Age and type of failure had no predictive value. Salvage therapy significantly improves outcome and, possibly, quality of life. As many different treatments were used conclusions cannot be made regarding an optimal treatment schedule.  (+info)

Low levels of cathepsin D are associated with a poor prognosis in endometrial cancer. (4/9672)

Total cytosolic cathepsin D (Cat D) levels were estimated by an immunoradiometric assay in a series of 156 consecutive patients with surgical stages I-III primary endometrial adenocarcinoma. Simultaneously, the tissue content of both oestrogen (ER) and progesterone (PR) receptors, and p185HER-2/neu, DNA content (ploidy), and the fraction of S-phase cells (S-phase) were also estimated. Tumoral Cat D content ranged from 0 to 243 pmol mg(-1) protein (median 44 pmol mg(-1) protein) and was not associated with any of the established clinicopathological and biological prognostic variables, with the exception of a weak positive correlation with the tumoral p185HER-2/neu levels. Univariable analysis performed on a subset of 97 patients, followed for a minimum of 2 years or until death, showed that patient age at diagnosis, high histological grade, advanced surgical stage, vascular invasion, positive peritoneal cytology, low levels of Cat D, negative ER and PR status, aneuploidy, and high S-phase were predictive of the presence of persistent or recurrent disease. However, multivariable analysis revealed that only histological grade, surgical stage, Cat D and PR were significantly associated with the patient's outcome. From these findings, we conclude that Cat D is an independent prognostic factor in endometrial adenocarcinoma, its low levels being associated with a worse clinical outcome.  (+info)

Clinical significance of circulating anti-p53 antibodies in European patients with hepatocellular carcinoma. (5/9672)

p53 alterations are considered to be predictive of poor prognosis in hepatocellular carcinoma (HCC) and may induce a humoral response. Anti-p53 serum antibodies were assessed by enzyme-linked immunosorbent assay (ELISA) using purified recombinant human p53 on 130 European HCC patients before treatment and during the clinical course of the disease. p53 immunohistochemistry was performed on tumours from the 52 patients who underwent surgery, and DNA sequencing analysis was initiated when circulating anti-p53 antibodies were detected. Nine (7%) HCC patients had anti-p53 serum antibodies before treatment. During a mean period of 30 months of follow-up, all the negative patients remained negative, even when recurrence was observed. Of the nine positive patients, eight were still positive 12-30 months after surgery. The presence of anti-p53 serum antibodies was correlated neither with mutation of the p53 gene nor the serum alpha-fetoprotein levels and clinicopathological characteristics of the tumours. However, a greater incidence of vascular invasion and accumulation of p53 protein were observed in the tumours of these patients (P<0.03 and P<0.01 respectively) as well as a better survival rate without recurrence (P = 0.05). In conclusion, as was recently shown in pancreatic cancer, anti-p53 serum antibodies may constitute a marker of relative 'good prognosis' in a subgroup of patients exhibiting one or several markers traditionally thought to be of bad prognosis.  (+info)

Immunocytochemically detected free peritoneal tumour cells (FPTC) are a strong prognostic factor in gastric carcinoma. (6/9672)

We prospectively investigated the prognostic significance of free peritoneal tumour cells (FPTC) in a series of 118 patients with completely resected gastric carcinoma. Immunocytochemistry with the monoclonal antibody Ber-Ep4 was performed on cytospins from intraoperative peritoneal lavage specimens. Twenty-three patients (20%) had FPTC which was significantly correlated with pT and pN categories, stage, tumour size, lymphatic invasion, Lauren and WHO classifications and perigastric adipose tissue metastases. The median survival time for all FPTC positive compared with negative patients was significantly shorter (11 compared with >72 months), with estimated 5-year survival rates of 8% vs. 60%. None of the patients with FPTC had an early gastric cancer. In advanced tumour subgroups without and with serosal invasion (n = 59 and 35), there were 19% and 34% with FPTC. Multivariate survival analysis showed nodal status, FPTC, mesenteric lymphangiosis, and lymph node metastasis to the compartment III to be independent prognostic factors with relative risks of 6.6, 4.5, 2.9 and 2.2 respectively. Recurrent disease occurred in 91% of FPTC-positive and in 38% of FPTC-negative patients. FPTC had a positive predictive value of 91% and a specificity of 97% for tumour recurrence. FPTC is a strong negative, independent prognostic indicator for survival in gastric carcinoma.  (+info)

Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer. (7/9672)

5-Fluorouracil (5-FU) is an effective enhancer of radiation therapy (RT) in head and neck cancers. Due to rapid, predominantly hepatic metabolism by dihydropyrimidine dehydrogenase (DPD) and suggested clinical benefit from prolonged drug exposure, 5-FU is commonly given by continuous infusion. Eniluracil is a novel DPD-inactivator designed to prolong the half-life of 5-FU and provide sustained plasma concentrations of 5-FU with oral dosing. We conducted a Phase I study of the safety and efficacy of eniluracil given with oral 5-FU in patients receiving concurrent RT for recurrent or advanced squamous cell carcinomas of the head and neck. Thirteen patients with recurrent, metastatic, or high-risk (defined as an expected 2-year survival rate of <10%) head and neck cancer were enrolled and treated with concomitant chemoradiotherapy on an every-other-week schedule. Eniluracil at a fixed dose [20 mg twice a day (BID)] was given for 7 consecutive days (days 1-7). 5-FU and RT were given on 5 consecutive days (days 2-6). One patient was treated with once-daily RT (2.0 Gy fractions). The remaining patients received hyperfractionated RT (1.5-Gy fractions BID). The initial dose of 5-FU was 2.5 mg/m2 given BID. Dose escalation in patient cohorts was scheduled at 2.5-mg/m2 increments, with intrapatient dose escalation permitted. Lymphocyte DPD activity and serum 5-FU and uracil concentrations were monitored during two cycles. DPD activity was completely or nearly completely inactivated in all patients. Sustained, presumed therapeutic concentrations of 5-FU were observed at a dose of 5.0 mg/m2 given BID. Cumulative dose-limiting myelosuppression (both neutropenia and thrombocytopenia) was observed during the fourth and fifth cycles following administration of 5.0 mg/m2 5-FU BID. One patient died of neutropenic sepsis during cycle 4. Other late cycle toxicities included diarrhea, fatigue, and mucositis. Grade 3 mucositis was observed in 4 patients, but no grade 4 mucositis or grade 3 or 4 dermatitis was observed. A second patient death occurred during cycle 1 of treatment. No specific cause of death was identified. The study was subsequently discontinued. Cumulative myelosupression was the significant dose-limiting toxicity of oral 5-FU given with the DPD-inactivator eniluracil on an every-other-week schedule. Clinical radiation sensitization was not observed, based on the absence of dose-limiting mucositis and dermatitis. Alternative dosing schedules need to be examined to determine the most appropriate use of eniluracil and 5-FU as radiation enhancers.  (+info)

Apoptosis during breast carcinoma progression. (8/9672)

The purpose of this study was to investigate apoptosis, proliferation, and the expression of apoptosis-influencing proteins bcl-2 and bax and estrogen and progesterone receptors during breast carcinoma progression. The material consisted of 53 paired breast carcinoma samples representing primary and recurrent tumors and 24 control samples. The recurrent sample was located either in the breast scar tissue or at a distant metastatic site. Apoptosis was detected both morphologically and by 3' end labeling of fragmented DNA. Cell proliferation was evaluated immunohistochemically by the MIB index. The expressions of bcl-2, bax, and estrogen and progesterone receptors were studied immunohistochemically. There was a significant increase in the extent of apoptosis and proliferation in recurrent tumors compared to the primary lesions (P = 0.015 and P = 0.038, respectively). In primary tumors with an apoptotic index of >0.50%, the survival of the patients was significantly shorter (P = 0.015). In cases with a significant increase in apoptosis or proliferation in the recurrent tumor, the survival of the patients was significantly shorter (P = 0.009 and P = 0.003, respectively). Of the variables analyzed, bcl-2 expression and a positive estrogen receptor status were significantly associated with a low extent of apoptosis (P = 0.010 and P = 0.042, respectively). Their changes were parallel to the changes in apoptosis during tumor progression, although the associations did not reach statistical significance. The results show that increased apoptosis is associated with a worse prognosis in breast carcinoma. A significant increase in apoptosis in recurrent breast carcinoma lesions predicts a worse clinical outcome.  (+info)

A growing body of evidence suggests that breast cancer recurrence risk is linked to lifestyle behaviors. This study examined correlations between breast cancer recurrence, risk reduction beliefs, and related behaviors among African American breast cancer survivors (AA BCSs). Study participants included 191 AA BCSs, mean age = 56.3 years, who completed a lifestyle assessment tool. Most respondents believed that being overweight (52.7%), lack of physical activity (48.7%), and a high fat diet (63.2%) are associated with breast cancer recurrence. Over 65% considered themselves overweight; one third (33.5%) agreed that losing weight could prevent recurrence, 33.0% disagreed, while the remaining 33.5% did not know; and nearly half (47.9%) believed that recurrence could be prevented by increasing physical activity. Almost 90% survivors with BMI < 25 Kg/M2 reported no recurrence compared to 75.7% with BMI ≥ 25 Kg/M2 (p = 0.06); nearly all of the women (99.2%) answered
Background In early breast cancer, variations in local treatment that substantially affect the risk of locoregional recurrence could also affect long-term breast cancer mortality. To examine this relationship, collaborative metaanalyses were undertaken, based on individual patient data, of the relevant randomised trials that began by 1995. Methods Information was available on 42 000 women in 78 randomised treatment comparisons (radiotherapy vs no radiotherapy, 23 500; more vs less surgery, 9300; more surgery vs radiotherapy, 9300). 24 types of local treatment comparison were identified. To help relate the effect on local (ie, locoregional) recurrence to that on breast cancer mortality, these were grouped according to whether or not the 5-year local recurrence risk exceeded 10% (?10%, 17 000 women; ?10%, 25 000 women). Findings About three-quarters of the eventual local recurrence risk occurred during the first 5 years. In the comparisons that involved little (?10%) difference in 5-year local recurrence
Purpose: To investigate clinicopathological features in patients with recurrent colorectal cancer within 1 year and more than 1 year after curative resection. Materials and Methods: We retrospectively evaluated 103 patients with disease recurrence before versus after 1 year of resection. Thirty-two patients (31%) were diagnosed with recurrence less than 1 year after curative resection for colorectal cancer (early recurrence) and 71 (69%) after more than 1 year (non-early recurrence). Results: The early recurrence group displayed a significantly lower overall survival rate for both colon cancer (p=0, 01) and rectal cancer (p|0.001). Inadequate lymph node dissection was a significant predictor for early relapse. There were no statistically significant differences in clinicopathological variables such as age, sex, primary tumor localization, stage, depth of invasion, lymphovascular invasion and perineural invasion between the early and non-early recurrence groups. However, a K-ras mutation subgroup was
As a result, the number of breast cancer survivors is growing. Oncology Nursing Consultant, Adjunct Assistant Professor of Nursing As time passes, the risk of recurrence steadily decreases. A 2019 study in PLoS One reported that women with triple-negative breast cancer (an especially aggressive form of the disease) have a greater risk of recurrence and death if regional lymph nodes are involved.. American Cancer Society. The risk of recurrence is higher the more advanced their cancer was. Tamoxifen Can Reduce the Risk of Recurrence by 50 percent, What It Means to Have Stage 1 Non-Small Cell Lung Cancer, How Aromatase Inhibitors Prevent Breast Cancer Recurrence, Breast Cancer Recurrence in the Chest Wall After Mastectomy. What Is cancer recurrence? However, recurrence can happen even many years after treatment, which is why its important to be breast and body aware, and report any changes to your treatment team or GP. J Pain Symptom Manage. A 2016 study from MD Anderson reported that, ...
Objective. This study examined recurrence patterns in breast cancer patients younger than age of 40 and older than age of 75, two groups that are underrepresented in clinical trials and not routinely screened by mammography. Methods. The records of 230 breast cancer patients (n = 125 less than 40 and n = 105 greater than 75) who presented to the Emory University Department of Radiation Oncology for curative treatment between 1997 and 2010 were reviewed. Data recorded included disease presentation, treatment, and areas of locoregional recurrence. Results. Women less than 40 years of age had higher rates of locoregional recurrence (20% versus 7%, P = 0.004) and distant recurrence (18% versus 5%, P = 0.003) than patients above 75 years of age. On multivariate analysis, patient age less than 40 was the only significant predictor of locoregional recurrence (P = 0.018). In a univariate analysis of each age group, receptor status and postlumpectomy radiation were significant predictors of locoregional ...
While previous research has shown that consumption of alcohol is associated with an increased risk of breast cancer, there have been limited studies about alcohols role in patient prognosis and survival among those already diagnosed with breast cancer.
Identifying patients at high risk of breast cancer recurrence: strategies to improve patient outcomes Yehoda M Martei,1 Jennifer M Matro1,21Department of Medicine, Hematology-Oncology Division, 2Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USAAbstract: Identifying patients at high risk of breast cancer recurrence has important implications not only for enabling the ability to provide accurate information to patients but also the potential to improve patient outcomes. Patients at high recurrence risk can be offered appropriate treatment to improve the overall survival. However, the major challenge is identifying patients with early-stage breast cancer at lower risk who may be spared potentially toxic therapy. The successful integration of molecular assays into clinical practice may address the problem of overtreatment and improve overall patient outcomes.Keywords: breast cancer, early stage, genomic assays, recurrence risk, recurrence score
Even 20 years after a diagnosis, women with a type of breast cancer fueled by estrogen still face a substantial risk of cancer returning or spreading, according to a new analysis from an international team of investigators published in the New England Journal of Medicine.
WEDNESDAY, Sept. 11 (HealthDay News) -- Researchers say theyve identified a genetic indicator of the long-term risk of breast cancer recurrence.. They compared three gene signature methods of predicting the risk of recurrence in patients treated for estrogen-receptor (ER)-positive breast cancer. They found that only the breast cancer index (BCI) -- a biomarker based on the expression levels of seven tumor-specific genes -- accurately identifies patients who continues to be at risk for breast cancer recurrence after five years of treatment with either tamoxifen or anastrozole, a drug in the aromatase inhibitor class.. The other two methods examined in the study were the Oncotype Dx Recurrence Score, the current gold standard for guiding clinical decision making, and the ICH4 gene signature, which is used less frequently used.. All three methods were able to predict recurrence risk in the first five years, but only the breast cancer index was able to accurately assess long-term recurrence risk, ...
TY - JOUR. T1 - Contemporary Locoregional Recurrence Rates in Young Patients With Early-Stage Breast Cancer. AU - Aalders, Kim C.. AU - Postma, Emily L.. AU - Strobbe, Luc J.. AU - van der Heiden-van der Loo, Margriet. AU - Sonke, Gabe S.. AU - Boersma, Liesbeth J.. AU - van Diest, Paul J.. AU - Siesling, Sabine. AU - van Dalen, Thijs. PY - 2016. Y1 - 2016. N2 - Purpose: The aim of this study was to evaluate contemporary rates of local recurrence (LR) and regional recurrence (RR) in young patients with breast cancer in relation to tumor biology as expressed by biomarker subtypes.Patients and Methods: Women , 35 years of age who underwent surgery for primary unilateral invasive breast cancer between 2003 and 2008 were selected from the Netherlands Cancer Registry. Patients were categorized according to biomarker subtypes on the basis of hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status. The 5-year risks of developing LR and regional lymph node recurrence were ...
TY - JOUR. T1 - The value of a positive margin for invasive carcinoma in breast-conservative treatment in relation to local recurrence is limited to young women only. AU - Jobsen, Jan J.. AU - Van Der Palen, Job. AU - Ong, Francisca. AU - Meerwaldt, Jacobus H.. PY - 2003/11/1. Y1 - 2003/11/1. N2 - Purpose: To identify the importance of positive margins for invasive carcinoma on local control in patients treated with breast-conservative treatment (BCT). Methods and Materials: A total of 1752 BCT with known margins were analyzed. Fifty-five patients had a second BCT, leaving 1697 patients for analysis. The margins were positive in 193/1752 BCT (11%). The median follow-up was 78 months. Results: The 5- and 10-year local recurrence rates (LRR) were 3.1% and 6.9%, respectively, for negative margins vs. 5.6% and 12.2% for positive margins. A statistical interaction between age category and margin status was noted in relation to disease-free survival (DFS) and local relapse-free survival. The 5-year ...
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The second type of recurrence is regional in nature. By regional we mean that the cancer has come back outside of the original breast and lymph node area. This is considered to be more serious than a local recurrence, but not as serious as a distant recurrence. The areas in which regional spread of the disease occur include the chest muscles (pectoral), the lymph nodes surrounding the neck area, the internal breast lymph nodes in the breast bone and rib areas and in the lymph nodes above the collarbone. This type of recurrence is rare. The third and most serious type of recurrence is called a distant recurrence. This is also referred to as a metastasis. The areas where distant spread can occur are most likely to occur are bone (25%), liver, brain, bone marrow, lungs or other organs. Sometimes this is referred to as metastatic disease or Stage IV breast cancer. The survival rate becomes much lower once metastasis occurs, with a life expectancy of 18 months on the average after discovering it. ...
To the best of our knowledge, the present study is the first to investigate the frequency and prognostic value of ALDH1 expression in IBTR tissues. The cut-off level for the classification of positive ALDH1 expression was set at ,1% in the current study, as there is no standardized cut-off level or method currently available. The ALDH1 positive cells were counted in hot spots, and positive ALDH1 expression was detected in 20% of the primary tumor samples and 23% of the IBTR tissue samples. The frequency of patients with ALDH1-expressing primary breast cancer (20%) in the current study was similar to that observed in previous studies (19, 17.5%) (10,11); however, the ALDH1 expression the in IBTR group (23%) was higher. It was hypothesized that this variation was due to the dissimilarities between the IBTR and primary tumors. IBTRs included new primary tumors and true recurrences following adjuvant therapy. Therefore, ALDH1-positive cancer stem cells within true recurrence were able to survive ...
There was no statistical difference in the 8 year local recurrence free survival in patients with VNPI scores of 3 or 4, regardless of whether or not radiation therapy was used (100% vs. 97%; P = not significant). Patients with VNPI scores of 5, 6, or 7 received a statistically significant 17% local recurrence free survival benefit when treated with radiation therapy (85% vs. 68%; P = 0.017). Patients with scores of 8 or 9, although showing the greatest relative benefit from radiation therapy, experienced local recurrence rates in excess of 60% at 8 years. Conclusions: ...
If there is a concern of a high-grade MCT, then other staging tests include abdominal ultrasonography, with ultrasound-guided aspirates of the liver and spleen, and bone marrow aspirates.. TREATMENT. The recommended treatment for MCTs is surgical excision. In dogs, lateral margins for excisionn should either be 2cm or equal to the maximal diameter of the MCT, whichever is greater, and one fascial layer for deep margins. In difficult locations where there is limited skin available for closure, preoperative biopsy is recommended as only 1 cm margins are required for excision of grade I MCTs and 2 cm margins for grade II MCTs. Local tumor recurrence rates using this approach ranges from 0% to 11%.. Radiation therapy has been recommended for locoregional tumor control in dogs with stage II MCT disease (i.e., dogs with lymph node metastasis) and possibly for the management of dogs with incompletely excised MCTs. Other options for the management of incompletely excised MCTs include monitoring ...
How the Breast Recurrence Score compares to traditional assessment methods, other genomic assays, the Breast DCIS Score, and to genetic tests.
The most commonly used gene expression profile test used to help predict breast cancer recurrence may not be as cost-effective as once thought, say a team of researchers led by Georgetown Lombardi Comprehensive Cancer Center.
Breast cancer recurrence can be overwhelming. Mental health strategies like cognitive behavioral therapy, support groups, mindfulness, and medications can help.
TY - JOUR. T1 - Refined estimates of local recurrence risks by DCIS score adjusting for clinicopathological features. T2 - a combined analysis of ECOG-ACRIN E5194 and Ontario DCIS cohort studies. AU - Rakovitch, E.. AU - Gray, R.. AU - Baehner, F. L.. AU - Sutradhar, R.. AU - Crager, M.. AU - Gu, S.. AU - Nofech-Mozes, S.. AU - Badve, S. S.. AU - Hanna, W.. AU - Hughes, L. L.. AU - Wood, W. C.. AU - Davidson, N. E.. AU - Paszat, L.. AU - Shak, S.. AU - Sparano, J. A.. AU - Solin, L. J.. PY - 2018/6/1. Y1 - 2018/6/1. N2 - Purpose: Better tools are needed to estimate local recurrence (LR) risk after breast-conserving surgery (BCS) for DCIS. The DCIS score (DS) was validated as a predictor of LR in E5194 and Ontario DCIS cohort (ODC) after BCS. We combined data from E5194 and ODC adjusting for clinicopathological factors to provide refined estimates of the 10-year risk of LR after treatment by BCS alone. Methods: Data from E5194 and ODC were combined. Patients with positive margins or multifocality ...
Researchers performed a retrospective analysis of 3 cohorts of women with prior history breast cancer and rheumatoid arthritis or inflammatory bowel disease to determine the risk of breast cancer recurrence with methotrexate, anti-TNF inhibitors, and thiopurines.
Reducing carbohydrate intake could reduce the risk of breast cancer recurrence among women whose tumor tissue is positive for the IGF-1 receptor, researchers report. Using an unusual approach, this study
&#13;&#13;&#13; &#13; &#13; &#13; &#13; &#13; Managing your&#13; fear of breast cancer recurrence
&#13;&#13;&#13; &#13; &#13; &#13; &#13; &#13; Managing your&#13; fear of breast cancer recurrence
Find out what happens if your breast cancer returns after treatment (recurrence), including information on local and regional recurrence (locally advanced breast cancer).
Although cancer doesnt define my life, it has certainly affected it dramatically. In November 2005, I was diagnosed with rectal cancer and treated throughout 2006. Until recently, there was no evidence of disease after treatment. Now, after unsuccessful attempts at palliative chemotherapy (including Avastin), I have opted for home palliative and hospice care. Quality of life is the goal of my treatment program. My unwanted journey thread will continue to document this significant aspect of my life journey ...
A recent study in the journal JAMA Oncology showed that simple lifestyle changes can reduce lung cancer and colorectal cancer in women by 85% and 60%
Patients are assigned to receive HPV E6 or E7 peptide by the principal investigator. Peripheral blood mononuclear cells (PBMC) (antigen presenting cells) are harvested and treated in vitro with sargramostim (GM-CSF) and pulsed with HPV16 E6 or E7. Patients receive vaccination with HPV16 E6 or E7 pulsed PBMC IV over 1-2 minutes during weeks 1, 3, 7, and 11 for a total of 4 vaccinations. Treatment continues in the absence of disease progression or unacceptable toxicity. Patients who achieve complete response (CR) continue treatment for a maximum of 1 year past CR.. Patients are followed at 1 month.. PROJECTED ACCRUAL: A total of 40-46 patients (at least 28 patients for stratum A and 12 for stratum B) will be accrued for this study within 1-2 years. ...
Patients are assigned to receive HPV E6 or E7 peptide by the principal investigator. Peripheral blood mononuclear cells (PBMC) (antigen presenting cells) are harvested and treated in vitro with sargramostim (GM-CSF) and pulsed with HPV16 E6 or E7. Patients receive vaccination with HPV16 E6 or E7 pulsed PBMC IV over 1-2 minutes during weeks 1, 3, 7, and 11 for a total of 4 vaccinations. Treatment continues in the absence of disease progression or unacceptable toxicity. Patients who achieve complete response (CR) continue treatment for a maximum of 1 year past CR.. Patients are followed at 1 month.. PROJECTED ACCRUAL: A total of 40-46 patients (at least 28 patients for stratum A and 12 for stratum B) will be accrued for this study within 1-2 years. ...
Sigma-Aldrich offers abstracts and full-text articles by [Lih-Chyang Chen, Li-Jie Wang, Nang-Ming Tsang, David M Ojcius, Chia-Chun Chen, Chun-Nan Ouyang, Chuen Hsueh, Ying Liang, Kai-Ping Chang, Chiu-Chin Chen, Yu-Sun Chang].
We studied the effect of postoperative radiotherapy (RT) after breast sector resection for ductal carcinoma in situ (DCIS). The study protocol stipulated radical surgery but microscopically clear margins were not mandatory. We randomised 1,046 operated women to postoperative RT or control between 1987 and 1999. The primary endpoint was ipsilateral local recurrence. Secondary endpoints were contralateral breast cancer, distant metastasis and death. After a median follow-up of 5.2 years (range 0.1-13.8) there were 44 recurrences in the RT group corresponding to a cumulative incidence of 0.07 (95% confidence interval (CI) 0.05-0.10). In the control group there were 117 recurrences giving a cumulative incidence of 0.22 (95% CI 0.18-0.26) giving an overall hazard ratio of 0.33 (95% CI 0.24-0.47, p , 0.0001). Twenty two percent of the patients had microscopically unknown or involved margins. We found no evidence for different effects of RT on the relative risk of invasive or in situ recurrence. ...
UroToday - GU OncToday brings coverage of the clinically relevant content needed to stay at the forefront of the dynamic field of GU oncology and urology.
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Aims to evaluate prognostic factors for local disease recurrence, distant metastases and cancer survival from anal cancer patients treated with concurrent chemoradiation at the Rosemere Cancer Centre. Zainul Abedin Kapacees short paper presentation at Tripartite 2014. ...
Scientists have identified genetic changes that may predict the likelihood of breast cancer relapse in women taking a common type of hormone therapy.
As part of an ongoing series of answers to common questions received by the Basser Center for BRCA, Executive Director Susan Domchek, MD, discusses typical guidelines for follow up to a potential recurrence of BRCA-related breast cancer.
Information for patients with invasive breast cancer (Stage 1-3a) about a genomic test to help determine whether chemotherapy is right for you.
Results from a new prospective clinical trial showed that a blood test looking at specific biomarkers was able to detect lung cancer recurrence about six months before conventional imaging methods found recurrence.
documentclass{article} % this is the default PlanetMath preamble. as your knowledge % of TeX increases, you will probably want to edit this, but % it should be fine as is for beginners. % almost certainly you want these \usepackage{amssymb} \usepackage{amsmath} \usepackage{amsfonts} % need this for including graphics (\includegraphics) \usepackage{graphicx} % for neatly defining theorems and propositions \usepackage{amsthm} % making logically defined graphics %\usepackage{xypic} % used for TeXing text within eps files %\usepackage{psfrag} % there are many more packages, add them here as you need them % define commands here \begin{document} Let $(X, \mathcal{B}, \mu)$ be a probability space, and let $T_i:X \rightarrow X$ be measure-preserving transformations, for $i$ between $1$ and $q$. Assume that all the transformations $T_i$ commute. If $E\subset X$ is a positive measure set $\mu(E)>0$, then, there exists $n \in \mathbb{N}$ such that $$\mu (E \cap T_1^{-n}(E) \cap \cdots \cap T_q^{-n}(E))>0$$ ...
High-spatial-resolution signal enhancement ratio (SER) imaging mayimprove prediction for patients at high risk for disease recurrence anddeath, according to a study in the July issue of Radiology.
Fifty-one patients were male, 32 female. Median age at diagnosis was 63.9 years (range 34.6-80.6). Most patients had a moderately differentiated adenocarcinoma (66.3%) and TNM disease stage IIB (51.8%). Mean SGLT1 score in primary tumors (n=83) was 4.24 (range 0.5-15.0). Mean Bcl-2 score in primary tumors (n=45) was 0.093 (range 0.0-3.0). Patients with high expression of Bcl-2 had significantly higher mean SGLT1 scores than those with lower Bcl-2 expression: 3.07 versus 5.87 (P=0.025). Mean SGLT1 score in metastases and local recurrent cancer was 2.05 (range 0.5-3.5), which was significantly lower than mean SGLT1 score of their respective primary tumors (3.38, P=0.022). Mean DFS is 12.7 months (median 7.0 months). On uni -and multivariate analysis TNM stage and SGLT1 score showed prognostic value (both P=0.021) for DFS. Mean OS is 20.86 months (median 14.0 months). Both on uni -and multivariate analysis TNM stage retained its prognostic value (P=0.012) and a trend was observed for mean SGLT1 ...
Cancer recurrence - Get the facts and learn to cope with the anger, distress and self-doubt you may feel when your cancer returns.
The PORTEC-1 trial has demonstrated that postoperative external beam radiotherapy for stage 1 endometrial cancer significantly increases local control (from 85 to 96%), but has no impact on survival. Salvage therapy for isolated vaginal recurrence, the main site of recurrence in the control group, was effective with a complete remission rate of 89% and actuarial 5-year survival of 65% in the control group. The use of postoperative RT should therefore be limited to the group of patients at sufficiently high risk of locoregional recurrence (15% or over) to warrant the risk of treatment associated morbidity in order to maximize initial local control and relapse-free survival ...
The goal of lumpectomy surgery for breast cancer is to completely remove the tumor and have clear margins, reducing the rates of local recurrence. The MarginProbe® System is a new device that can detect microscopic tumor cells at or close to the margin of the surgical resection intraoperatively ...
On Tuesday my PET CT came back suggestive of recurrence in the right pelvic sidewall. Because a biopsy at the time of my cancer surgery two years ago told us there were cancer cells there, we knew this day would come. Those cells were sleeping during my remission but appear to have woken up. Getting cancer just as the world goes under with COVID19 is such unimaginable bad luck I can barely comprehend it ...
TT User Setup 7.4.2 introduced support for product margins per market rather than only per flavor. When configuring products that are hosted on more than one gateway flavor per market, you now create only one product margin rather than one for each gateway flavor.. When upgrading from a version prior to 7.4.2, there may be multiple product margins in a market that are already configured for the same product. When the margins are identical for these products, TT User Setup merges them into a single product margin. However, if the product margins are not identical, your TT User Setup administrator must review the conflicts and decide which margin to use. ...
Characterizing patient-oncologist communication in genomic tumor testing: The 21-gene recurrence rating as an exemplar Goal: Ladies with early-stage, ER + breast most cancers are advocate to obtain genomic profiling checks, such because the 21-gene Recurrence Rating (RS) take a look at, to information remedy selections. We examined test- and treatment-related data mentioned and the associations between RS […]. ...
Once cancer treatment is complete it is time to restore and rejuvenate the body by feeding it with the best foods for optimal nutrition.
Figure 2. Because these patients are not curable, the goal of therapy becomes the improvement in both quality and length of life.
PURPOSE:To investigate the role of quantitative pre-treatment dual-energy computed tomography (DECT) for prediction of loco-regional recurrence (LRR) in patients with larynx/hypopharynx squamous cell cancer (L/H SCC). METHODS:Patients with L/H SCC treated with curative intent loco-regional radiotherapy and that underwent treatment planning with contrast-enhanced DECT of the neck were included. Primary and nodal gross tumor volumes (GTVp and GTVn) were contoured and transferred into a Matlab® workspace. Using a two-material decomposition, GTV iodine concentration (IC) maps were obtained. Quantitative histogram statistics (maximum, mean, standard deviation, kurtosis and skewness) were retrieved from the IC maps. Cox regression analysis was conducted to determine potential predictive factors of LRR. RESULTS:Twenty-five patients, including 20 supraglottic and 5 pyriform sinus tumors were analysed. Stage I, II, III, IVa and IVb constituted 4% (1 patient), 24%, 36%, 28% and 8% of patients, ...
The aim of the present analysis was to evaluate the recurrence pattern in patients with recurrent malignant glioma after re-irradiation in combination with bevacizumab as there is limited data on how to optimally choose dose, fractionation and delineation margins. Thirty-one patients with recurrent malignant glioma treated with re-irradiation and bevacizumab after previous chemoradiotherapy (concurrent temozolomide 75 mg/m2/d according to the EORTC/NCIC trial) and [18 F]FET-PET and/or MRI confirmed recurrence were retrospectively analyzed. Bevacizumab was applied twice during fractionated re-irradiation (10 mg/kg, d1 + d15, median 36 Gy, conventionally fractionated). Recurrence patterns were assessed by means of [18 F]FET-PET and/or MRI. Median follow-up was 34.0 months for all patients [95%-CI, 27.7-40.3] and median post-recurrence survival 10.8 months [95%-CI, 9.2-12.4]. Concerning the recurrence patterns, 61.3% of these were located in-field (19 patients), 22.6% were marginal (7 patients) and 16.1%
TY - JOUR. T1 - A Phase II evaluation of weekly topotecan as a single agent second line therapy in persistent or recurrent carcinoma of the cervix. T2 - A Gynecologic Oncology Group study. AU - Fiorica, James V.. AU - Blessing, John A.. AU - Puneky, Louis V.. AU - Secord, Angeles Alvarez. AU - Hoffman, James S.. AU - Yamada, S. Diane. AU - Buekers, Thomas E.. AU - Bell, Jeffrey. AU - Schilder, Jeanne M.. PY - 2009/11/1. Y1 - 2009/11/1. N2 - Purpose: To estimate antitumor activity and toxicity of weekly topotecan hydrochloride in patients with persistent or recurrent cervical carcinoma who failed prior treatment. Patients and methods: Women entered on study had or failed one prior chemotherapy regimen in addition to radiosensitizing chemotherapy, performance status less than 3, and adequate hematologic, renal, hepatic, and neurological function. Topotecan was infused at 3.0 mg/m2 on days 1, 8, and 15 every 28 days. Results: Twenty-seven patients were enrolled onto this study with 25 evaluable. ...
The 21-gene recurrence score significantly predicted the risk of recurrence and death in node-positive, estrogen receptor-positive patients treated with adjuvant chemoendocrine therapy, but it did not predict benefit from the addition of paclitaxel to the regimen in a subset of patients from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-28 trial,1 according to Eleftherios (Terry) P. Mamounas, MD, MPH, FACS, Professor of Surgery at Northeastern Ohio Universities College of Medicine and Medical Director of the Comprehensive Breast Program at MD Anderson Cancer Center, Orlando, Florida, and Chairman of the Breast Committee of the NSABP Operations and Biostatistical Center, Pittsburgh, Pennsylvania.. Study Goals. The goal of this substudy was to evaluate the recurrence score as a predictor of the risk of local-regional recurrence in node-positive, estrogen receptor-positive patients treated with adjuvant endocrine therapy and chemotherapy. The secondary goal was to evaluate ...
TY - JOUR. T1 - Changes of KRAS Exon 2 Codon 12/13 Mutation Status in Recurrent Colorectal Cancer. AU - Dócs, Ottó. AU - Fazakas, Ferenc. AU - Horváth, Nóra Lugosiné. AU - Tóth, L.. AU - András, C.. AU - Horváth, Z.. AU - Méhes, G.. PY - 2014/9/24. Y1 - 2014/9/24. N2 - Colorectal cancer (CRC) is a heterogeneous disease presenting with a wide spectrum of morphological and molecular characteristics sometimes even within the same patient. To understand the mechanisms of oscillations in the KRAS status we evaluated the collective of CRC patients tested using allele-specific PCR and Sanger-sequencing. Mutant KRAS allele was observed in 43.3 % of cases. Repeated analysis of KRAS status in recurrent tumors or metastases was performed in 18/665 cases and a total of 6 cases with different KRAS status was found. In three cases the histological pattern of the tumor was identical. In one patient different histology and molecular status was seen between the primary and the recurrent tumor samples. ...
Obesity is associated with an increased risk of breast cancer recurrence and cancer death. Recurrent cancers arise from the pool of residual tumor cells, or minimal residual disease (MRD), that survives primary treatment and persists in the host. Whether the association of obesity with recurrence risk is causal is unknown, and the impact of obesity on MRD and breast cancer recurrence has not been reported in humans or in animal models. Doxycycline-inducible primary mammary tumors were generated in intact MMTV-rtTA;TetO-HER2/neu (MTB/TAN) mice or orthotopic recipients fed a high-fat diet (HFD; 60% kcal from fat) or a control low-fat diet (LFD; 10% kcal from fat). Following oncogene downregulation and tumor regression, mice were followed for clinical recurrence. Body weight was measured twice weekly and used to segregate HFD mice into obese (i.e., responders) and lean (i.e., nonresponders) study arms, and obesity was correlated with body fat percentage, glucose tolerance (measured using intraperitoneal
The purpose of this study is to determine the activity of SCH 717454 in patients with relapsed or recurrent colorectal cancer.
Of the 449 patients who received neoadjuvant chemotherapy, 98 underwent breast-conserving surgery. The average diameter of the tumors was 5.3 cm, and 87.2% reached a size of up to 3 cm. Moreover, 86.7% were classified as clinical stage III, 74.5% had T3-T4 tumors, 80.5% had N1-N2 axilla, and 89.8% had invasive ductal carcinoma. A pathologic complete response was observed in 27.6% of the tumors, and 100.0% of samples had free margins. The 5-year actuarial overall survival rate was 81.2%, and the mean follow-up was 72.8 months. The rates of ipsilateral breast tumor recurrence and locoregional recurrence were 11.2% and 15.3%, respectively. Multifocal morphology response was the only factor related to ipsilateral breast tumor recurrence disease-free survival ...
The prognostic role of positive circumferential resection margins after curative intent surgery for locally advanced esophageal adenocarcinoma
The management of rectal cancer has changed in many countries over the last two decades and resulted in improved survival for the majority of rectal cancer patients. In this thesis some surgical strategies and histopathological aspects to improve and clarify the management of rectal cancer patients are investigated.. Even in the era of TME surgery and radiotherapy, a higher local recurrence rate and shorter survival for rectal cancer patients operated with abdominoperineal resection is reported. In the first paper we describe a new strategy with partial anterior en bloc resection of either the prostate or the vagina, resulting in very low local recurrence rates and excellent long-term survival. Histopathological examination of the specimen lays the foundation for decision making on oncological therapy. A positive circumferential resection margin (CRM) has, in previous papers, been related to a high risk of local recurrence. In the second paper we show that a CRM ≤ 1 mm was not correlated with ...
BACKGROUND: In breast cancer patients (≥70 years), tumour resection plus tamoxifen (T + T) has a higher loco-regional relapse (LR) rate than mastectomy. This study examines factors influencing local recurrence in these cases. METHODS: Clinical records of 71 patients aged ≥70 years, randomised to the T + T arm of 2 randomised trials were reviewed. Cox Proportional Hazards model was used to determine the most significant variables. RESULTS: After 15-years follow-up, LR relapse occurred in 29/71, of whom 5 had synchronous metastatic disease. Most tumours recurred in the index quadrant. Subsequently 21/24 patients with loco-regional recurrence only had salvage mastectomy. Three variables significantly predicted LR: lympho-vascular invasion (LVI) (HR [95% CI]: 11.18 [4.47, 27.95], p | 0.01), ER negative status (HR [95% CI]: 0.27 [0.10, 0.72] p = 0.01), and tumour necrosis (HR [95% CI]: 2.65 [1.10, 6.37], p = 0.03). Final margin status was not associated with LR. CONCLUSIONS: Tumour resection + Tamoxifen
Statins and risk of breast cancer recurrence Minas Sakellakis,1 Karolina Akinosoglou,1 Anastasia Kostaki,2 Despina Spyropoulou,1 Angelos Koutras,1 1Department of Medicine, Division of Oncology, University Hospital, Patras Medical School, Patras, 2Department of Statistics, Athens University of Economics and Business, Athens, Greece Background: The primary end point of our study was to test whether the concurrent use of a statin is related to a lower risk of recurrence and increased relapse-free survival in patients with early breast cancer. Materials and methods: We reviewed 610 female patients with stage I, II, or III breast cancer who had been surgically treated and who had subsequently received at least adjuvant chemotherapy in order to prevent recurrence. Results: Among the 610 patients with breast cancer, 83 (13.6%) were receiving a statin on a chronic basis for other medical purposes. Overall, statin users displayed longer mean relapse-free survival (16.6 vs 10.2 years, P=0.028). After data had
Read Erratum to: Focal salvage therapy for local prostate cancer recurrences after primary radiotherapy: a comprehensive review, World Journal of Urology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Six modern, prospective, randomized trials have demonstrated that breast-conserving therapy (lumpectomy followed by radiation) offers survival rates equivalent to mastectomy (Table 61-1)1-7; however, when negative margins are not achieved or when radiation therapy is not pursued, breast conservation is associated with higher rates of local recurrence (Tables 61-1 and 61-2).1,2,8-14 Until recently, the impact of local recurrence on survival remained unclear. In 2005, the Early Breast Cancer Trialists Collaborative Group (EBCTCG) published the results of a large meta-analysis combining all individual patient data for 42,080 women who collectively took part in 78 treatment comparisons (more vs less surgery, more surgery vs radiotherapy, radiotherapy vs none) to determine the impact of local recurrence on survival. Specifically, among 10 breast-conservation trials included in the EBCTCG analysis (7311 women), postoperative radiation treatment (XRT) was associated with a statistically significant ...
The present invention relates to a scoring system for the prediction of cancer recurrence. More particularly, the present invention concerns with the selection of genes and/or proteins, and generation of formulae with the selected genes and/or proteins for the prediction of cancer recurrence by measuring the expression of genes and/or proteins of human tumor tissues, and comparing their patterns with those of the gene and/or protein expression of human primary tumors from patients who have cancer recurrence and those who do not have cancer recurrence. The present invention also relates to a kit for performing the method of the present invention comprising DNA chip, oligonucleotide chip, protein chip, peptides, antibodies, probes and primers that are necessary for effecting DNA microarrays, oligonucleotide microarrays, protein arrays, northern blotting, in situ hybridization, RNase protection assays, western blotting, ELISA assays, reverse transcription polymerase-chain reaction (hereinafter referred to
With the increasing incidence of ESCC in Asia, it has been reported that the recurrence rate of patients with ESCC following surgery ranges from 36.1% to 64.2%.[6, 20, 21]. Overall survival rates at 2 and 5 years are 22% and 11%, respectively, with a median survival time of only 7 months[16, 17]. Locoregional recurrence after curative esophagectomy in patients with esophageal cancer remains a challenge to clinical oncologists, regardless of the pathological type. The National Comprehensive Cancer Network (NCCN) guidelines indicate that a subgroup of patients with postoperative locoregional recurrence may be able to tolerate concurrent radiochemotherapy[9, 16, 26]. The limited survival benefit may arise from the limited competence of the routine radiation technique. With the disadvantage of localization using 2-dimensional radiation fields, the radiation doses for the targeted tumor in patients with locoregional recurrent ESCC could not satisfy the demands of the prescribed doses. Curative ...
As mentioned, one of the most important partners in allowing or preventing metastatic cell survival and growth is immune cancer surveillance [20]. If immune surveillance and its proper balance are key to prevent or fight against an effective metastatic process, it is likely that disruption of the immune surveillance system plays a key role in the recognition of HCC recurrence. Immune surveillance is the result of several factors that are the consequence of the relationship between the personal inflammatory/immune phenotype and the modification of the inflammation process that is in place during viral infection and its modification by effective therapy. Thus, inflammatory status with heterogeneous activation of stromal cells and lymphocyte recruitment is sure responsible for the delay, or even complete abrogation, of the growth of clones of cells that may have nested away from the primary tumor. In the setting of DAA-based antiviral therapy, there is an extremely fast inhibition of HCV ...
Local recurrence is a major cause of morbidity and mortality, usually implies a worse prognosis. It may occur as a result from two potential etiopathogeneses. First, metastases through endothelial-lined channels occur to both lymphatic and hematogenous routes [18], which are controlled by neoadjuvant therapy and optimal TME. Indeed, TME reduced the high local recurrence rates from 30-40% to 5-10% [19] and even greater when associated with chemoradiotherapy (CRT) [20]. The second is by implantation of viable exfoliated malignant cells from a rectal adenocarcinoma on preexisting benign perineal lesions [21-24]; it was estimated that 70% of the specimens were found to have viable exfoliated colorectal cancer cells with median cell number ranging from 0.55 × 105 to 0.78 × 10 [6].. Since the first case of cell implantation into the anal fistula in 1954 by Guiss [4], several case reports and small case series reported the colorectal cancer recurrence on preexisting benign perineal lesions such as ...
and LinkedIn.. This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to the benefits of the Oncotype DX Breast Recurrence Score test to physicians, patients and payors; the results of the TAILORx study including its implications on clinical treatment decisions; the ability of the Oncotype DX Breast Recurrence Score test to improve patient outcomes; and the ability of the company to expand commercial access and increase utilization of its Oncotype DX Breast Recurrence Score test. Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially, and reported results should not be considered as an indication of future performance. These risks and uncertainties include, but are not limited to: the results of clinical studies; the applicability of clinical study results to actual outcomes; the ability of the test results to change treatment ...
Despite improvements in adjuvant therapy, late systemic recurrences remain a lethal consequence of both early- and late-stage breast cancer. A delayed recurrence is thought to arise from a state of tumor dormancy, but the mechanisms that govern tumor dormancy remain poorly understood. To address the features of breast tumors associated with late recurrence, but not confounded by variations in systemic treatment, we compiled breast tumor gene expression data from 4,767 patients and established a discovery cohort consisting of 743 lymph node-negative patients who did not receive systemic neoadjuvant or adjuvant therapy. We interrogated the gene expression profiles of the 743 tumors and identified gene expression patterns that were associated with early and late disease recurrence among these patients. We applied this classification to a subset of 46 patients for whom expression data from microdissected tumor epithelium and stroma was available, and identified a distinct gene signature in the stroma and
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial t
True or False. A positive margin which is defined as ink on ductal carcinoma in situ (DCIS) is associated with an increase in ipsilateral breast tumor recurrence (IBTR), which is nullified by the use of whole-breast radiation therapy (WBRT). ...
See also bug #70693 Activesyncd is losing the nth attribute for monthly repeating BYDAY events. The following EAS data: ,Recurrence xmlns=Calendar:, ,Recurrence_Type,3,/Recurrence_Type, ,Recurrence_Interval,1,/Recurrence_Interval, ,Recurrence_WeekOfMonth,1,/Recurrence_WeekOfMonth, ,Recurrence_DayOfWeek,16,/Recurrence_DayOfWeek, ,/Recurrence, is turned into the following RRULE: RRULE:FREQ=MONTHLY;BYDAY=TH which should be: RRULE:FREQ=MONTHLY;BYDAY=1TH This is obviously related to bug #70693. Until I investigate further, I dont know if this is caused by the same underlying problem as that bug, is a deliberate attempt to avoid triggering that bug or is a separate bug. Even if this is separate, bug #70693 may still prevent the corrected event from being synchronised. As events with recurrence like first Monday of the month are very common, it would be nice to fix this ...
Treatment of recurrent breast cancer depends mainly on where the cancer recurs and past treatment. Learn about treatment of local or metastatic recurrence.
Treatment of recurrent breast cancer depends mainly on where the cancer recurs and past treatment. Learn about treatment of local or metastatic recurrence.
Approximately 10% to 15% of patients with stage I/II invasive breast cancer will develop a clinically isolated local recurrence. The standard management of an ipsilateral breast tumor recurrence following breast- ...
Eliminating pro-inflammatory cells after treatment relieves symptoms in mice.. January 17, 2017/Novato, California: Standard chemotherapy is a blunt force instrument against cancer - and its a rare cancer patient who escapes debilitating side effects from systemic treatments that mostly affect dividing cells, both malignant and healthy, throughout the body. Researchers at the Buck Institute and elsewhere now show that chemotherapy triggers a pro-inflammatory stress response termed cellular senescence, promoting the adverse effects of chemotherapy as well as cancer relapse and metastasis. Eliminating the senescent cells in mice prevented the side effects and relapse. The research is published in Cancer Discovery.. While chemotherapy does save lives, it often comes with a very high price, said Judith Campisi, PhD, Buck faculty and senior scientist on the study. Our work in mice studied the effects of chemotherapy on cancer relapse and other serious side effects. It provides a ...
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TY - JOUR. T1 - Evaluation of HER-2 neu oncoprotein expression as a prognostic indicator of local recurrence in conservatively treated breast cancer. T2 - A case-control study. AU - Haffty, Bruce G.. AU - Brown, Felix. AU - Carter, Darryl. AU - Flynn, Stuart. PY - 1996/7/1. Y1 - 1996/7/1. N2 - Purpose: The purpose of this study is to determine the prognostic significance of overexpression of the HER-2 neu oncoprotein with respect to local relapse following conservative surgery and radiation therapy (CS+RT). Methods and Materials: Twenty consecutive patients who sustained a local recurrence as the first and only site of failure following CS+RT comprised the case population base for this study. Only patients who received no adjuvant systemic chemotherapy or tamoxifen were selected for analysis. Following the identification of 20 consecutive local-relapse patients, the patient database was searched for 20 matching control patients who did not sustain a local relapse. Each control patient was ...
Optimizing the odds of avoiding cancer recurrence: Go jogging in your Speedo or bikini!. I have been looking around, mostly on pubmed ( https://www.ncbi.nlm.nih.gov/pubmed/ ), for non-chemotherapy strategies to reduce cancer recurrence and mortality. To avoid an overlong post, I will summarize very briefly the information I have found, with hopefully a link to one supporting study. If the topic interests you, I encourage you to go to pubmed and read more. Of course, all of this information is from my perspective only and you should use it as a springboard for discussion with your doctor or your own research.. Vitamin D: One of the most surprising results of my research was the impact of vitamin D on colorectal cancer recurrence and mortality. One article reports, Freedman et al demonstrated in one of the largest prospective studies including 16,818 participants that CRC mortality was inversely related to serum 25(OH)D level. Individuals with serum levels of 50-80 ng/mL and , 80 ng/mL had a ...
While we do not talk about recurrence much in my family, everyone knows way too much about it because we all remember my mothers experience. She was diagnosed at an early stage. Low grade. Her cancer still metastasized.. Broadly speaking, the greatest risk of recurrence is during the first two years following diagnosis. Certain more aggressive breast cancers are more likely to metastasize early on, before the five year benchmark. Others, like my mothers and mine (ER+,PR+), are less likely to metastasize early on, but can and sometimes do many years later. A reader (thank you) shared this piece, Understanding the Risk of Late Recurrence of Breast Cancer.. The bottom line is, theres no guarantee. The five-year benchmark suggesting youre cured is a myth that has been perpetuated for years partly due to Pink Ribbon Fantasy Land hype.. Many women (and men) do struggle with recurrence worries.. Perhaps adding to this worry (for me anyway and perhaps for you, too) is the fact that generally ...
Eighty-five patients met the inclusion criteria, and 27% of them had an atypical histology. Typical EVNs had a better prognosis than atypical EVNs after primary treatment, with a 5-year recurrence rate of 36% compared with 68% (p , 0.001), and a 5-year mortality rate of 4% compared with 44%, respectively (p , 0.001). Age younger 50 years was associated with a better prognosis than age equal to or greater than 50 years, with a 5-year recurrence rate of 33% and 74%, respectively (p , 0.001), and a 5-year mortality rate of 4% and 52%, respectively (p , 0.001). Multivariate analysis demonstrated that atypical EVNs carried significantly increased risk for recurrence (hazard ratio [HR] 4.91, p , 0.001) and death (HR 22.91, p , 0.01). Gross-total resection was superior to subtotal resection (STR) alone in tumor control rates for typical EVNs (95% and 68%, p , 0.05), and there was a trend for adjuvant external-beam radiotherapy to benefit STR. There was suggestion of similar trends in patients with ...
Immunotherapy (tumor vaccine) is recommended for dogs with malignant melanoma because of the high risk of metastasis to the lymph nodes and lungs. Chemotherapy is recommended for dogs with oral osteosarcoma. Chemotherapy should also be considered for other oral tumors and the palliative management of cats with SCC.. PROGNOSIS. Dogs. Malignant Melanoma. Malignant melenoma is the most common oral tumor in dogs and also has the highest metastatic potential, particularly to the regional lymph nodes and lungs. Based on a combination of early papers, the local recurrence rate following mandibulectomy was 22% with a median survival time of 9-11 months and a 1-year survival rate of 21%. Similarly, the local recurrence rate following maxillectomy is as high as 48% with a median survival time of 5-10 months and a 1-year survival rate of 27%. However, in two large 2014 studies, the overall local recurrence rate was 16%-17%. Clinical stage has prognostic significance with median survival times of 20 months ...
There has been scanty data regarding the clinical significance of tumor conspicuity in pancreatic cancer. In this study, we attempted to investigate the prognostic significance of pancreatic tumor conspicuity and determine prognostic factors for postoperative recurrence in patients with surgically resected pancreatic cancer. Between January 2011 and September 2019, 62 patients who underwent preoperative computed tomography (CT) for pancreatic cancer were retrospectively included. Two reviewers evaluated various clinical, imaging, and pathologic variables and reviewed all available medical records to determine patient outcomes after surgery. Tumor conspicuity was defined as the attenuation ratio between normal parenchyma and tumor lesions on dynamic-enhanced CT images and represented the conspicuity score. Recurrence-free survival and overall survival were investigated using Cox regression analysis. Patient mean age was 65.9 (±11.6) years, and 56.5% were male. The median follow-up period was 11 months
Recurrent Breast cancer can return after successful treatment. The initial treatment involves eliminating all cancer cells, but it is possible for a few to
Although the initial cancer treatment is aimed at eliminating all cancer cells, a few of them may still stay in the body, which likely cause breast cancer recurrence. Breast cancer can recur at any time but mostly occur in the first three to five year
The main objective of the current investigation was to study the efficacy of EPA as an inhibitor of recurrent colorectal cancer growth and to determine whether EPA in combination with FuOx would be more effective than either agent/regimen alone.. The preventive and therapeutic efficacy of a combination of EPA and DHA or each PUFA alone has been demonstrated in multiple preclinical studies using a variety of rodent models of early-stage colorectal cancer (37). These studies have consistently demonstrated reduction in colorectal cancer incidence (reviewed in ref. 37). Our data demonstrate for the first time that EPA acts synergistically with FuOx to markedly inhibit the growth of chemoresistant colon cancer cells that form bulk of the recurrent tumor. Although the underlying cause for tumor recurrence is not fully understood, one of the reasons is thought to be the presence of CSCs/CSLCs that are resistant to conventional chemotherapy and retain limitless potential to regenerate (1-3, 38). The ...
Process monitoring is an important research problem in numerous areas. This paper proposes a novel process monitoring scheme by integrating the recurrence plot (RP) method and the control chart technique. Recently, the RP method has emerged as an effective tool to analyze waveform signals. However, unlike the existing RP methods that employ recurrence quantification analysis (RQA) to quantify the recurrence plot by a few summary statistics; we propose new concepts of template recurrence plots and continuous-scale recurrence plots to characterize the waveform signals. A new feature extraction method is developed based on continuous-scale recurrence plot. Then, a monitoring statistic based on the top- approach is constructed from the continuous-scale recurrence plot. Finally, a bootstrap control chart is built to detect the signal changes based on the constructed monitoring statistics. The comprehensive simulation studies show that the proposed
For treatment, most women with newly diagnosed ovarian cancer undergo surgery to remove as much of the visible tumor as possible and determine a specific diagnosis. Survival time is markedly better for women who have complete tumor removal, yet great variability exists in the extent of tumor removal. For women in whom an optimal removal is not feasible, or who are unable to undergo surgery, neoadjuvant chemotherapy can reduce tumor size and facilitate subsequent surgical resection. While the majority of women respond well to initial treatments, most will experience a recurrence of ovarian cancer, and virtually all recurrent ovarian cancers ultimately become resistant to current drug therapies. The committee said there is a need for better tools to predict near- and long-term response to treatments for both newly diagnosed and recurrent cancers.. While clinicians should have better ways to select the most appropriate treatment for individual patients, they also require more treatment options, and ...
Weill Cornell Medicine is one of only a handful of locations in the United States enrolling patients in this innovative trial for GBM
Mark G. Kris, MD, chief of the Thoracic Oncology Service at Memorial Sloan-Kettering Cancer Center, describes the genetic mutation screening multicenter study that he was the lead author for and presented at the 2011 annual meeting of the American Society of Clinical Oncology.
Portrait of Mark Ptashne (born 1940), US molecular biologist. Ptashne was the first scientist to demonstrate specific binding between protein and DNA. Much of his research has focused on molecular mechanisms in the lifecycle of the virus bacteriophage lambda. He holds the Ludwig Chair of Molecular Biology at Memorial Sloan-Kettering Cancer Center in New York, where he works on gene regulation mechanisms in yeast. - Stock Image C021/9054
CVSROOT: /cvs/purrs Module name: purrs Changes by: zolo at cs.unipr.it 2003-11-14 12:45:47 Modified files: demos : purrs_rrs_cgi.cc src : Recurrence.cc Recurrence.defs.hh Recurrence.inlines.hh rr_classifier.cc tests : rrs_driver.cc Log message: Removed the status `HAS_HUGE_DECREMENT from `Solver_Status. Now the status `HAS_HUGE_DECREMENT of `Classifier_Status is mapped in the status `TOO_COMPLEX of `Solver_Status. Added and fixed several comments. Patches: http://www.cs.unipr.it/cgi-bin/cvsweb.cgi/purrs/demos/purrs_rrs_cgi.cc.diff?cvsroot=purrs&r1=1.24&r2=1.25 http://www.cs.unipr.it/cgi-bin/cvsweb.cgi/purrs/src/Recurrence.cc.diff?cvsroot=purrs&r1=1.121&r2=1.122 http://www.cs.unipr.it/cgi-bin/cvsweb.cgi/purrs/src/Recurrence.defs.hh.diff?cvsroot=purrs&r1=1.126&r2=1.127 http://www.cs.unipr.it/cgi-bin/cvsweb.cgi/purrs/src/Recurrence.inlines.hh.diff?cvsroot=purrs&r1=1.88&r2=1.89 http://www.cs.unipr.it/cgi-bin/cvsweb.cgi/purrs/src/rr_classifier.cc.diff?cvsroot=purrs&r1=1.75&r2=1.76 ...
Treatment is by simple enucleation and local curettage, and recurrence is rare. Clinically, they are initially slow growing and ... Squamous odontogenic tumors (SOTs) are very rare benign locally infiltrative odontogenic neoplasms of epithelial origin. Only ...
There is so far no evidence of metastases or local recurrence. Metanephric adenoma is diagnosed histologically. The tumours can ... Of further relevance is that this tumour is more commonly calcified than any other kidney neoplasm. Surgery is curative and no ... the frequent gain of chromosomes 7 and 17 and losses of the Y chromosome that are typical of papillary renal cell neoplasms, ...
... of cases have had local recurrence whereas some demonstrate regional lymph node or osseous metastasis. The rare neoplasms ... The standard duration between diagnosis and reappearance was "23 months, 50 months, and 66 months for local recurrence, nodal ... and local recurrence" (IADVL, 2004). Though it is usually found within women in the forties, the youngest-recorded case was ... The patient has a routine check-up of every three months to ensure no recurrence occurs and so far, has not had any relapse for ...
Surgical excision is usually curative and local recurrences are rare, although malignant tumors may metastasize. Gross ... Obaidat NA, Alsaad KO, Ghazarian D (February 2007). "Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat ... clear cell type Spiroma List of cutaneous conditions List of cutaneous neoplasms associated with systemic syndromes Laws RA, ...
... neoplasm seeding MeSH C23.550.727.650.895 - neoplasms, unknown primary MeSH C23.550.727.655 - neoplasm recurrence, local MeSH ... neoplasm metastasis MeSH C23.550.727.650.560 - lymphatic metastasis MeSH C23.550.727.650.645 - neoplasm circulating cells MeSH ... C23.550.727.670 - neoplasm regression, spontaneous MeSH C23.550.727.700 - neoplasm, residual MeSH C23.550.737.500 - retrograde ... recurrence MeSH C23.550.325.250 - mediastinal emphysema MeSH C23.550.325.500 - subcutaneous emphysema MeSH C23.550.355.500 - ...
An associated skin disease favors recurrence. This may be attributed to the persistent colonization of abnormal skin with S. ... Bacterial colonisation begins in the hair follicles and can cause local cellulitis and inflammation. Myiasis caused by the ... lymphoproliferative neoplasms, malnutrition, and use of immunosuppressive drugs. People with recurrent boils are as well more ...
Recurrence rates are high, and therefore there is a poor prognosis. There is frequently local tissue invasion and metastasis to ... A mammary tumor is a neoplasm originating in the mammary gland. It is a common finding in older female dogs and cats that are ... Removal should be with wide margins to prevent recurrence, taking the whole mammary gland if necessary. Because 40 to 50 ... Benjamin S, Lee A, Saunders W (1999). "Classification and behavior of canine mammary epithelial neoplasms based on life-span ...
... invasive carcinoma that has penetrated the muscularis mocos has the potential for lymph node metastasis and local recurrence ... Paris classification of colorectal neoplasms. In colonoscopy, colorectal polyps can be classified by NICE (Narrow-band imaging ... A neoplasm is a tissue whose cells have lost normal differentiation. They can be either benign growths or malignant growths. ...
... surgical resection of local tumor could lead to complete cure without recurrence in 20-25% of patients. Gastrinoma is the ... Patients with gastrinomas that are also known to be part of neuroendocrine neoplasms must have to deal with two factors related ... Patients who do not seek medical treatment such anti-ulcer medication have high rate of recurrence and death secondary to ulcer ... arise as primary neoplasms in lymph nodes of the pancreaticoduodenal region (gastrinoma triangle). Most gastrinomas are ...
Recurrence has been reported to occur as many as 36 years after treatment. To reduce the likelihood of recurrence within ... Wang A, Zhang B, Huang H, Zhang L, Zeng D, Tao Q, Wang J, Pan C (June 2008). "Suppression of local invasion of ameloblastoma by ... The neoplasms are often associated with the presence of unerupted teeth, displacement of adjacent teeth and resorption of roots ... Recurrence is common, although the recurrence rates for block resection followed by bone graft are lower than those of ...
... had a non-recurrence rate after four years of 97.9% in one retrospective study. There is a chance of sarcoid recurrence for all ... Sarcoids are the most common type of skin neoplasm and are the most common type of cancer overall in horses. Squamous-cell ... Prognosis and treatment effectiveness varies based on type of cancer, degree of local tissue destruction, evidence of spread to ... Surgical removal alone is not effective, with recurrence occurring in 50 to 64% of cases, but removal is often done in ...
Recent statistics demonstrate that EMC shows a higher incidence of local recurrence, metastasis and patient mortality and ... EMC shows the smallest morphological variation between the tumors among all myxoid soft tissue neoplasms. The myxoid matrix has ... Local recurrences occur in up to 48% of patients. Metastasis occurs in approximately 50% of cases with the most frequent ... Extraskeletal myxoid chondrosarcoma (EMC) is a rare low-grade malignant mesenchymal neoplasm of the soft tissues, that differs ...
Such techniques ensure that adequate resection margins are obtained at the time of surgery to minimize tumor recurrence. The ... Hemipelvectomy is generally reserved for the treatment of pelvic neoplasms. Examples of malignancies that are treated with ... and magnetic resonance imaging help the surgeon visualize the anatomy and its relationship to the local pathology. Surgical ...
Local recurrence has been described after simple surgical excision but it is rare.[citation needed] Histologically vast array ... Oliveira AM, Chou MM (January 2014). "USP6-induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular ... Because recurrence is rare, even when there is incomplete excision, in case of recurrence initial diagnosis of nodular ...
The risk of developing local recurrence or metastases is related to the histologic grade, according to the above-named features ... They account for less than 1% of all breast neoplasms. This is predominantly a tumor of adult women, with very few examples ... Radiation treatment after breast-conserving surgery with negative margins may significantly reduce the local recurrence rate ... The common treatment for phyllodes is wide local excision. Other than surgery, there is no cure for phyllodes, as chemotherapy ...
Moreover, the liposuctioning of the breast does not increase the rate of local medical complications; decreased NAC sensitivity ... given the hypertrophy's high rate of recurrence.[citation needed] Breast reduction by liposuction only cannot be performed upon ... liposuction mammoplasty also is contraindicated for any woman whose mammograms indicate the presence of unevaluated neoplasms; ...
This is due to the proportionally higher rate of local recurrence for these higher-grade tumors. Grade II tumors may behave ... The neoplasms currently referred to as meningiomas were referred to with a wide range of names in older medical literature, ... Even if, by general rule, neoplasms of the nervous system (brain tumors) cannot metastasize into the body because of the blood- ... Goyal LK, Suh JH, Mohan DS, Prayson RA, Lee J, Barnett GH (January 2000). "Local control and overall survival in atypical ...
In thyroid neoplasm, TAZ allows follicular adenomas to be distinguished from follicular carcinomas, while in cervical cancer ... A common phenotype is both generalized and local weakness. Weakness is exhibited as overt muscle weakness and increased ... potentially offering insight into cancer recurrence in patients. A potential link between PI3K and TAZ indicates a possible ... TAZ overexpression has been linked to rectal cancer, prostate cancer, thyroid neoplasm, and cervical cancer. In a study of 140 ...
Frequent (44%) local recurrence is seen, often many years after the initial presentation. As of 2012[update], no regional or ... Definitions: A low-grade spindle-cell neoplasm of the sinonasal tract associated with overlying respiratory epithelium and ... Infiltrative, highly cellular spindled cell neoplasm is poorly circumscribed and unencapsulated. Bone destruction or invasion ...
It has a slow infiltrative growth and a high rate of local recurrence if not completely excised. Sclerosing DFSP is a variant ... As with many other stromal neoplasms, DFSPs appear to express low levels of hormone receptors, which may be one factor that ... Distant hematogenous metastases are even rarer and are most likely in patients who have had multiple local recurrences after ... Recurrence rate with WLE is about 8.5% with a lower recurrence rate related to wider excision. DFSP characteristic features are ...
Stage II is a tumor extending in the local area, or that with any evidence of limited neck (nodal) disease. Stage III is a ... Additionally, chemotherapy can be used as an adjuvant therapy after radiation to lower the risk of recurrence in the patient. ... Nasopharyngeal carcinoma, also known as nasopharyngeal cancer, is classified as a malignant neoplasm, or cancer, arising from ... More importantly, EBV DNA levels appear to correlate with treatment response and may predict disease recurrence, suggesting ...
... local dissection of the tumor is not recommended due to high incidence of recurrence. The facial nerve should be preserved ... Morphological diversity is the most characteristic feature of this neoplasm. Histologically, it is highly variable in ... Malignant salivary tumors usually require wide local resection of the primary tumor. However, if complete resection cannot be ... Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation of parenchymatous ...
Recurrence of enchondromas was observed in some cases. In cases of Ollier disease, early surgical treatment of enchondromas in ... While chondrosarcoma is the most common form of a secondary malignant bone neoplasm found in cases of Ollier disease, other ... wide-local excisions, hemipelvectomy, and arthroplasty. Cobalt and chemotherapy are typically not primary methods of surgery as ... Early detection and consistent and repeated monitoring is important in order to prevent and treat any potential bone neoplasms ...
Furthermore, MMS is associated with significantly lower local and distant recurrence rates in both periocular and extraocular ... SGc is often misdiagnosed as an inflammatory condition or a more common neoplasm. SGc is commonly treated with wide local ... Local SGc is most commonly managed with local resection and/or radiation therapy. Systemic therapy for metastatic disease is ... increasing the risk of local recurrence. Immunohistochemistry may be used to establish a definitive diagnosis, but it is not ...
... of the Bartholin gland is another uncommon malignancy with symptoms that include local painful intermittent recurrences. The ... of all vulvar malignant neoplasms. It is most common in women in their mid-60s. The tumor can become large before a woman is ...
High failure and recurrence rates are expected in the presence of larger or intramural fibroids. Radiofrequency ablation is a ... Fibroids can be mistaken for ovarian neoplasms. An uncommon tumor which may be mistaken for a fibroid is Sarcoma botryoides. It ... Also, with advanced malignant lesions, there may be evidence of local invasion. A biopsy is rarely performed and if performed, ... In leiomyoma with vascular invasion, an ordinary-appearing fibroid invades into a vessel but there is no risk of recurrence. In ...
Local recurrences of the disease in non-pseudocyst sites did occur but responded to further treatment. Three individuals with ... An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation". The ... 30 of the 36 cases of FA-DBCL for which there is follow-up results had a benign course with no disease recurrence over 1 to 130 ...
Overall, the outcome is good, although it is quite unpredictable, with about 30% of patients have a recurrence. In about 10% of ... Definitions: A rare, biphasic, neuroblastic, and pigmented epithelial neoplasm of craniofacial sites, usually involving the ... there is usually a benign clinical course after complete local excision (usually by partial maxillectomy) with clear or free ...
The rationale of hypofractionation is to reduce the probability of local recurrence by denying clonogenic cells the time they ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... It may also be used as palliative treatment (where cure is not possible and the aim is for local disease control or symptomatic ... It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor ...
The UCSF Cancer of the Prostate Risk Assessment (CAPRA) score predicts both pathologic status and recurrence after surgery. It ... "Male Genitals - Prostate Neoplasms". Pathology study images. University of Virginia School of Medicine. Archived from the ... In the United States, prostate cancer that is local or regional at the time of diagnosis has a 5-year survival rate of nearly ... "Veterans exposed to Agent Orange have higher rates of prostate cancer recurrence". Medical College of Georgia News. May 20, ...
Secondary neoplasm[edit]. Development of secondary neoplasia after successful chemotherapy or radiotherapy treatment can occur ... Neoadjuvant chemotherapy is given prior to a local treatment such as surgery, and is designed to shrink the primary tumor.[3]: ... but there is risk of recurrence.[3]:55-59 It is also useful in killing any cancerous cells that have spread to other parts of ... Systemic therapy is often used in conjunction with other modalities that constitute local therapy (i.e. treatments whose ...
"How well does the new lung cancer staging system predict for local/regional recurrence after surgery?: A comparison of the TNM ... 8560-8580) Complex epithelial neoplasms. Carcinoma In situ[edit]. The term carcinoma in situ (or CIS) is a term for cells that ... If this process of continuous growth, local invasion, and regional and distant metastasis is not halted via a combination of ... The hallmark of a malignant tumor is its tendency to invade and infiltrate local and adjacent structures and, eventually, ...
Local trauma is also associated with aphthous stomatitis, and it is known that trauma can decrease the mucosal barrier. Trauma ... Recurrence may be so frequent that ulceration is virtually continuous. It generally occurs in a slightly older age group than ... Salivary gland neoplasms *Benign: Basal cell adenoma. *Canalicular adenoma. *Ductal papilloma. *Monomorphic adenoma ... For example, there is some evidence that vitamin B12 supplementation may prevent recurrence in some individuals.[20] ...
Radioactive iodine brachytherapy at the margins of wedge excision may reduce the risk of recurrence. Rarely, removal of a whole ... Depending on the type of tumor, paraneoplastic phenomena-symptoms not due to the local presence of cancer-may initially attract ... Horn, L; Lovly, CM; Johnson, DH (2015). "Chapter 107: Neoplasms of the lung". In Kasper, DL; Hauser, SL; Jameson, JL; Fauci, AS ... However, wedge resection has a higher risk of recurrence than lobectomy. ...
The average five-year recurrence rate in people where surgery is successful is 5% for stage I cancers, 12% in stage II and 33% ... Srikumar Chakravarthi; Baba Krishnan; Malathy Madhavan (1999). "Apoptosis and expression of p53 in colorectal neoplasms". ... epigenetic alterations and local inflammatory changes.[48] The polyp to CRC sequence can be used as an underlying framework to ... The two most common sites of recurrence of colorectal cancer are the liver and lungs.[19] ...
Local skin flaps are a method of closing defects with tissue that closely matches the defect in color and quality. Skin from ... Tumors: Skin neoplasm, skin appendages / Adnexal and skin appendage (C44.L40-L68/D23.L15-49, 173/216) ... and whether the cancer is primary or a recurrence. For a small basal-cell cancer in a young person, the treatment with the best ... Various forms of local flaps can be designed to minimize disruption to surrounding tissues and maximize cosmetic outcome of the ...
Predictive factors for local recurrence in osteosarcoma: 540 patients with extremity tumors followed for minimum 2.5 years ... Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms. „In Vivo". 21 (5 ...
It can occur more than a week before or after a symptomatic recurrence in 50% of cases.[33] Virus enters into susceptible cells ... One of the projects of The Herpes Resource Center (HRC) was to create a network of local support (HELP) groups. The goal of ... Salivary gland neoplasms *Benign: Basal cell adenoma. *Canalicular adenoma. *Ductal papilloma. *Monomorphic adenoma ... During recurrence, fewer lesions are likely to develop and are less painful and heal faster (within 5-10 days without antiviral ...
In the skin, the virus causes local inflammation and blistering. The short- and long-term pain caused by shingles outbreaks ... and it is extremely rare for a person to have more than three recurrences.[30] ... Salivary gland neoplasms *Benign: Basal cell adenoma. *Canalicular adenoma. *Ductal papilloma. *Monomorphic adenoma ... Two to four days before the rash occurs there may be tingling or local pain in the area.[1][7] Otherwise there are typically ...
Gastric cancer: preoperative local staging with 3D multi-detector row CT--correlation with surgical and histopathologic results ... Impact of the extent of surgery and postoperative chemoradiotherapy on recurrence patterns in gastric cancer. „J Clin Oncol". ... Benefits of endoscopic submucosal dissection according to size and location of gastric neoplasm, compared with conventional ... Extended local resection for advanced gastric cancer: increased survival versus increased morbidity. „Ann Surg". 236 (2), s. ...
Local recurrences tend to behave similarly to a primary unless they are at the site of a wide local excision (as opposed to a ... Tumors: Skin neoplasm, nevi and melanomas (C43/D22, 172/216, ICD-O 8720-8799) ... It may reduce the rate of local recurrence but does not prolong survival.[119] Radioimmunotherapy of metastatic melanoma is ... Often this is done by a wide local excision (WLE) with 1-2 cm (0.4-0.8 in) margins. Melanoma-in-situ and lentigo malignas are ...
Fibroids can be mistaken for ovarian neoplasms. An uncommon tumor which may be mistaken for a fibroid is Sarcoma botryoides. It ... In leiomyoma with vascular invasion, an ordinary-appearing fibroid invades into a vessel but there is no risk of recurrence. ... Also, with advanced malignant lesions, there may be evidence of local invasion. A biopsy is rarely performed and if performed, ... High failure and recurrence rates are expected in the presence of larger or intramural fibroids. ...
breast cancer metastasis neoplasm chemotherapy Mouse models of breast cancer metastasis Phyllodes tumour "Secondary (metastatic ... interactions with local factors promoting tumor-cell growth, survival, angiogenesis, invasion and metastasis. This is explained ... hence allowing for tumor recurrence in the central nervous system. The main steps involved in the metastatic cascade of a ...
Park KK, Brodell RT, Helms SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis; cutaneous medicine for the ... Prodromal (day 0-1): Symptoms often precede a recurrence. Symptoms typically begin with tingling (itching) and reddening of the ... Salivary gland neoplasms *Benign: Basal cell adenoma. *Canalicular adenoma. *Ductal papilloma. *Monomorphic adenoma ... Cold sore outbreaks may be influenced by stress, menstruation, sunlight, sunburn, fever, dehydration, or local skin trauma. ...
Recurrence in the residual cervix is very rare if the cancer has been cleared with the trachelectomy. Yet, women are ... Alternatives include local surgical procedures such as a loop electrical excision procedure or cone biopsy. A systematic review ... Myung SK, Ju W, Kim SC, Kim H (October 2011). "Vitamin or antioxidant intake (or serum level) and risk of cervical neoplasm: a ... Lin Y, Zhou J, Dai L, Cheng Y, Wang J (September 2017). "Vaginectomy and vaginoplasty for isolated vaginal recurrence 8 years ...
This specific type of tumor appears to have a high potential for local recurrence with a high tumor bed recurrence rate during ... The critical diagnosis of this neoplasm is often difficult because of its similarity with other primary or secondary papillary ... is a recently described neoplasm that has been formally recognized in the 2007 World Health Organization (WHO) "Classification ...
Exceptions include local or metastasis-directed therapy with radiation may be used for advanced tumors with limited metastasis ... "Male Genitals - Prostate Neoplasms". Pathology study images. University of Virginia School of Medicine. Archived from the ... US war veterans who had been exposed to Agent Orange had a 48% increased risk of prostate cancer recurrence following surgery.[ ... In India in the 1990s, half of those diagnosed with local cancer died within 19 years. One study reported that African- ...
It was overexpressed in cancers that later developed local or distant recurrence. Its expression did not correlate with the ... In contrast to most other cancers, adrenocortical neoplasms appear to have decreased expression of H19. To determine a possible ... reported no cancer recurrence and no side effects. The ovarian cancer patient experienced a 50% decline in the amount of the ... cancer recurrence and malignant potential. The activation of the H19 promoter in cancerous cells (and its silence in normal ...
A meta analysis of local tetracycline found improvement. Local application of statin may be useful. Systemic drug delivery in ... Therefore if the brushing techniques are not modified, a periodontal recurrence is probable. Most alternative "at-home" gum ... neoplasms, endocrine, nutritional and metabolic, and traumatic lesions or gingival pigmentation. Periodontitis Necrotizing ... Local drug deliveries in periodontology has gained acceptance and popularity compared to systemic drugs due to decreased risk ...
For patients who develop local or regional recurrences after their initial radiation therapy, physicians are limited in their ... Two prominent examples are pediatric neoplasms (such as medulloblastoma) and prostate cancer. Irreversible long-term side ... A study led by Memorial Sloan Kettering Cancer Center suggests that IMPT can improve local control when compared to passive ... 2005). "Increased risk of biochemical and local failure in patients with distended rectum on the planning CT for prostate ...
Its expression is also increased in a wide range of other malignant neoplasms. Factor X (F10) is frequently expressed in normal ... However, it is the F protein (one of many membrane fusion proteins) that, when triggered by local dehydration and a ... tumor recurrence, and overall patient survival for an extremely wide range of cancers. Therefore, SeV virus preferentially can ... March 2000). "Fusogenic membrane glycoproteins as a novel class of genes for the local and immune-mediated control of tumor ...
The disease has a tendency to develop local recurrences and metastasis thereafter to regional lymph nodes, lung, bone, brain, ... a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study ... Rao, Bhaskar N.; Rodriguez-Galindo, Carlos (2003). "Local control in childhood extremity sarcomas: Salvaging limbs and sparing ...
... therapy after submucosal injection of normal saline solution for local recurrence of large nonampullary duodenal neoplasm. ... therapy after submucosal injection of normal saline solution for local recurrence of large nonampullary duodenal neoplasmArgon ...
"Neoplasm Recurrence, Local" by people in this website by year, and whether "Neoplasm Recurrence, Local" was a major or minor ... The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have ... "Neoplasm Recurrence, Local" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Neoplasm Recurrence, Local" by people in Profiles. ...
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have ...
Access scientific research and medical evidence related to Neoplasm Recurrence, Local quickly, easily and effectively with ... Neoplasm Recurrence, Local research, articles, guidelines & medical evidence database search.. Title. Abstract. Authors. ... Access the latest scientific research and medical evidence related to Neoplasm Recurrence, Local treatment, diagnosis and ... Access the latest scientific research and medical evidence related to Neoplasm Recurrence, Local treatment, diagnosis and ...
Neoplasms - diagnosis Neoplasms - psychology Neoplasms - complications Neoplasm Recurrence, Local - psychology Neoplasm ... Neoplasms - psychology Neoplasm Recurrence, Local - psychology Neoplasm Metastasis Palliative Care Social Support Adaptation, ... Neoplasms - psychology Neoplasm Recurrence, Local - psychology Popular Works Abstract. Adapted from a publication by US ... Neoplasms - psychology - popular works - pamphlets Neoplasm Recurrence, Local - psychology - popular works - pamphlets Abstract ...
Local recurrence. 25. All. Child, Adult, Senior. NCT03169439. IREAT. July 1, 2017. April 1, 2019. August 1, 2019. May 30, 2017 ... recurrence free survival. 100. All. Child, Adult, Senior. NCT02555163. Mans17-9-2015. HoLERBT. September 2015. September 2017. ... Time-to-event, where event is defined as the earliest occurrence any of the following: Locoregional/distant recurrence of the ... neoplasms [CONDITION] AND child [AGE-GROUP] , Recruiting, Not yet recruiting, Available Studies (1984 records) ...
Overall survival Local recurrence Early or late complication associated with preoperative radiotherapy Quality of life Accuracy ... Resection rate, rate of sphincter preservation, tumor regression, cumulative incidence of local and distant recurrences, ... Irreversible Electroporation(IRE) For Unresectable Rectal Neoplasms. *Rectal Neoplasms. *Procedure: Irreversible ... local control. 25. All. 18 Years and older (Adult, Senior). NCT00910494. EB/JK/LET/LN1277. January 2010. January 2012. January ...
Neoplasm Recurrence, Local * Neoplasm Staging * Prognosis * Survival Rate Grant support * R01 DK029961-19/DK/NIDDK NIH HHS/ ...
Neoplasm Metastasis * Neoplasm Recurrence, Local / pathology* * Neoplasm Recurrence, Local / therapy* * Neoplasm Staging ... Patients whose local disease was treated by surgical resection had a 3-year local control rate of 71% compared with 38% by ... The recurrent disease was stage II in 61%, stage III in 30%, and stage IV in 9%. The local disease was rT1-2 in 67% and rT3-4 ... Further locoregional failure represents the major failure pattern, and the proportion of patients who had further local, ...
Bladder neoplasm. Intravesical drug administration. Neoplasm recurrence, local. Transitional cell, carcinoma. Carcinoma in situ ... Neoplasms. Urinary Bladder Neoplasms. Urologic Neoplasms. Urogenital Neoplasms. Neoplasms by Site. Urinary Bladder Diseases. ... Bladder Neoplasms Drug: Mycobacterial cell wall-DNA complex Phase 2 Phase 3 ... Efficacy and safety of MCNA in patients with nonmuscle invasive bladder cancer at high risk for recurrence and progression ...
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; COMPARATIVE EVALUATIONS; NEOPLASMS; PATIENTS; RECTUM; REVIEWS; SURGERY; ... The overall salvage rate for local recurrence was 93%. Local recurrence-free survival at 5 years was 69% (all local recurrences ... Local recurrence may develop in 31% of patients with initial cCR when early regrowths (≤12 months) and late recurrences are ... and late recurrences were considered together, 28 patients (31%) experienced local recurrence (median follow-up time, 60 months ...
Neoplasm Recurrence, Local / therapy. Neoplasm Staging. Ovarian Neoplasms / mortality, radiotherapy, therapy*. Prognosis. ... 22283194 - P-cadherin expression in merkel cell carcinomas is associated with prolonged recurrence.... ...
Neoplasm Recurrence, Local / mortality, pathology, surgery. Neoplasm Staging. Radiotherapy, Adjuvant. Retrospective Studies. ... 21946765 - Local lymph node micrometastasis in a patient with negative sentinel lymph node biopsie.... 9738805 - Prognostic ... Cerebellar Neoplasms / mortality, pathology, surgery*. Cerebrospinal Fluid Shunts. Chemotherapy, Adjuvant. Combined Modality ... Only the histological type has a statistically significant influence on survival and recurrence: we have found that patients ...
Treated by simple excision or wide local excision to prevent local recurrence ... Lipoma: most common benign soft tissue neoplasm. Subcutaneous tissues of trunk and proximal limbs (thighs). Frequently solitary ... Local excision, with recurrence ,2%. *Angiomyolipoma: renal tumor composed of fat, smooth muscle, and blood vessel. Presents ... Due to location, excision often has close margins, and local recurrence 10-20% ...
Four of 6 patients with MDTs who died had local recurrence. One patient died of liver metastasis and 1 of esophageal cancer. ... of Intraductal papillary mucinous neoplasm of the pancreas (IPMN): Evaluation and management. 66 ...
Neoplasm Recurrence, Local. *Genetic Predisposition. *Germ-Line Mutation. *DNA Repair. *Chromosome 10 ... tissue samples with early recurrence (less than 1 year, with invasion and metastasis out of liver) and late recurrence (longer ... The recurrence-free and overall survival rates of patients in Cluster B1 were lower than those of patients in Clusters A and B2 ... Recurrence, invasion, and metastasis are the major reasons of the low 5-year survival of hepatocellular carcinoma. However, the ...
Neoplasm recurrence local.. Receptor epidermal growth factor. Vascular endothelial growth factor. Resumo em inglês ... Local recurrence of squamous cell carcinomas of the mouth and oropharynx: a study of anatomic pathology variables and ... CONCLUSION: Local recurrence in oral and oropharyngeal squamous cell carcinomas usually indicates an unfavorable prognosis. A ... METHODS: The charts of 111 patients with local recurrence of oral or oropharyngeal squamous cell carcinomas were ...
Neoplasm Recurrence, Local. *Cancer Gene Expression Regulation. *Base Sequence. *Membrane Glycoproteins. *Lymphoma ... Mature lymphoid neoplasms (MLN) are clinically and pathologically more complex than precursor lymphoid neoplasms. Until ... Disease-specific mutations in mature lymphoid neoplasms: recent advances.. Cancer Sci. 2014; 105(6):623-9 [PubMed] Related ...
Objectives To determine the value of 18F-FDG-PET/MRI in the diagnosis and management of patients with pelvic recurrence of ... Positron-emission tomography Magnetic resonance imaging Rectal cancer Neoplasm Recurrence, local The original version of this ... Huguier M, Houry S, Barrier A (2001) Local recurrence of cancer of the rectum. Am J Surg 182:437-439CrossRefGoogle Scholar ... Hupkens BJP, Maas M, Martens MH et al (2017) MRI surveillance for the detection of local recurrence after transanal endoscopic ...
Neoplasm Metastasis. *Neoplasm Recurrence, Local. *Recurrence. .map{width:100%;height:300px;margin-bottom:15px}. Name. Location ...
If there has been no local recurrence or metastasis, rate on residuals.. ... DC 7914: Neoplasm, Malignant, Any Specified Part of the Endocrine System. *DC 7915: Neoplasm, Benign, Any Specified Part of the ... DC 7915: Neoplasm, Benign, Any Specified Part of the Endocrine System. VA proposes to retain the existing direction to rate ... 7914 Neoplasm, malignant, any specified part of the endocrine system. 100. Note: A rating of 100 percent shall continue beyond ...
If there has been no local recurrence or metastasis, rate on residuals. ... 6820 Neoplasms, benign, any specified part of respiratory system. Evaluate using an appropriate respiratory analogy. ... 6819 Neoplasms, malignant, any specified part of respiratory system exclusive of skin growths. 100 ...
Breast Neoplasms. *Neoplasm Recurrence, Local. *Breast Neoplasms. *Neoplasms. *Neoplasm Recurrence, Local. *Recurrence ... Screening MRI for Cancer Recurrence in Patients Treated With Breast Conserving Therapy. Trial Phase:. N/A. Minimum Age:. 20 ... Patients treated with breast conserving therapy will be followed for recurrence in the. ipsilateral or contralateral breast by ...
Neoplasm Recurrence, Local. 1. 2015. 7710. 0.040. Why? Sterol Regulatory Element Binding Proteins. 1. 2015. 30. 0.040. Why? ...
Local Neoplasm Recurrence * Blood Disorders * Lung Cancer * Cancerous Tumor * Cancer * Kidney Cancer ...
Local Neoplasm Recurrence * Deviated Septum * Nasopharynx Cancer (Nasopharyngeal Neoplasm) * Head and Neck Cancer ...
Palabras clave : COLONIC NEOPLASMS; COLONIC NEOPLASMS [therapy]; COLONIC NEOPLASMS [surgery]; NEOPLASM RECURRENCE, LOCAL; ... Teaching Provincial Hospital of Santiago de Cuba from 1990 to 2008 that presented tumorous recurrence, diagnosed in outpatient ... because during that biennium most of the recurrences take place in any localization. ...
Neoplasm Recurrence, Local. 3. 2019. 7780. 0.070. Why? Chemical Phenomena. 2. 2002. 681. 0.070. Why? ...
Local recurrences are common and systemic dissemination is rare. Histologic examination of involved lymph nodes shows ... Therapy-related myeloid neoplasms. Therapy-related myeloid neoplasms (t-MNs) remain as a distinct category in the ... "systemic mastocytosis with an associated hematological neoplasm (SM-AHN)." In many cases, the AHN is an aggressive neoplasm ... Myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1 or with PCM1-JAK2. The ...
Local recurrences after radiotherapy for prostate cancer (PCa) often originate at the location of the macroscopic tumour(s). ... The biochemical recurrence after local treatment for prostate cancer is an often challenging condition of clinical management. ... Prostate cancer recurrence in vas deferens - fusion image guide as an important tool in diagnosis. ... Predicting biochemical recurrence and prostate cancer specific mortality after radical prostatectomy: comparison of six ...
  • Chemotherapy, local recurrence, lymph node metastasis, and poorly differentiated tumour were significantly associated with survival. (hkmj.org)
  • There are reports of local recurrence as well as metastasis to the lymph nodes and lungs. (thedoctorsdoctor.com)
  • In this system, designations T, N, and M were used to describe tiie extent of local involvement and of local and distant metastasis: T describes the extent of local tumor involvement, N refers to local or regional lymph node involvement, and M designates metastasis. (healio.com)
  • These tumors are classified as anaplastic (malignant) meningiomas of WHO grade III (MIII) ( 2 ) and are associated with a high risk for local recurrence and metastasis ( 1 ). (pnas.org)
  • 4 ] In general, thymomas are indolent tumors with a tendency toward local recurrence rather than metastasis. (healthlinkbc.ca)
  • Liver transplantation may be an effective therapeutic method for the treatment of cHCC-CC. Strict screening of potential liver transplantation candidates with cHCC-CC can help reduce the risks of tumor recurrence and metastasis. (biomedcentral.com)
  • No histologic or molecular parameters exist at the present time that could predict the development of metastasis in these neoplasms. (scirp.org)
  • She developed two recurrences in 2000 and 2001, but 25 years later the first operation she presented a metastasis in her right gluteal region with evidence of local recurrence. (scirp.org)
  • The tumor has a propensity for local recurrence and recurrent hemorrhage but rarely for remote metastasis. (thejns.org)
  • Approximately 10% of cases of SFTP demonstrate malignant potential, leading to local recurrence after radical surgery and subsequent metastasis. (dovepress.com)
  • However, the high rate of distant metastasis has not been addressed by these local modalities of therapy. (aacrjournals.org)
  • Although chemotherapy has been used for unresectable disease and to palliate local-regional recurrence, the role of adjuvant chemotherapy has not been clearly defined in preventing distant metastasis. (aacrjournals.org)
  • Seventeen patients received surgery for regional and/or local failures with or without combined radiotherapy (ST group), 14 patients received reirradiation to both local and regional disease (RT group), and 12 patients received palliative chemotherapy only (CT group). (nih.gov)
  • Patients whose local disease was treated by surgical resection had a 3-year local control rate of 71% compared with 38% by reirradiation using brachytherapy or external radiotherapy. (nih.gov)
  • Based on clinical experience, many centers advocate postoperative radiotherapy to help limit local failure. (oralcancerfoundation.org)
  • Swedish Rectal Cancer Trial : long lasting benefits from radiotherapy on survival and local recurrence rate. (diva-portal.org)
  • Radiotherapy improves local control following incomplete resection, but nearby organs at risk may limit the dose to the target volume. (ufl.edu)
  • Currently, DCIS accounts for 20-25% of all newly diagnosed cases of breast cancer [ 3 ] and 17-34% of mammographically detected breast neoplasms [ 4 , 5 ]. (hindawi.com)
  • The primary head and neck neoplasms involved the maxillary sinus (eight cases), hard palate (one case), and infratemporal fossa (two cases). (ajnr.org)
  • INTRODUCTION: Local and regional relapses are the main sites of treatment failure in patients with oral and oropharyngeal squamous cell carcinoma. (usp.br)
  • Albersen M, Parnham A, Joniau S, Sahdev V, Christodoulidou M, Castiglione F, Nigam R, Malone P, Freeman A, Jameson C et al (2017) Predictive factors for local recurrence after glansectomy and neoglans reconstruction for penile squamous cell carcinoma. (springer.com)
  • Agrawal A, Pai D, Ananthakrishnan N, Smile SR, Ratnakar C (2000) The histological extent of the local spread of carcinoma of the penis and its therapeutic implications. (springer.com)
  • Parathyroid carcinoma is an extremely rare malignant endocrine neoplasm that is very challenging in its diagnosis as well as its treatment. (egms.de)
  • Their study showed that MA lacks the frequent gain of chromosomes 7 and 17 and losses of the Y chromosome that are typical of papillary renal cell neoplasms, suggesting that MA is not related to renal cell carcinoma and papillary adenoma. (wikipedia.org)
  • Several nomograms were developed for predicting the potential recurrence and cancer death risk in renal cell carcinoma patients. (medscimonit.com)
  • Adenoid cystic carcinoma (ACC) is an uncommon form of malignant neoplasm that arises within secretory glands, most commonly the major and minor salivary glands of the head and neck. (oralcancerfoundation.org)
  • Adenosquamous Carcinoma of the Salivary Glands is an extremely rare malignant neoplasm that simultaneously arises from surface mucosal epithelium and salivary gland ductal epithelium. (disabled-world.com)
  • This carcinoma behaves aggressively with extensive infiltrating local disease as well as distant metastatic disease. (disabled-world.com)
  • Adenosquamous Carcinoma - Limited data indicate that this is a highly aggressive neoplasm with a poor prognosis. (disabled-world.com)
  • Ductal carcinoma in situ (DCIS) of the breast is a heterogeneous neoplasm with invasive potential. (hindawi.com)
  • The critical diagnosis of this neoplasm is often difficult because of its similarity with other primary or secondary papillary lesions of the pineal region, including parenchymal pineal tumors, papillary ependymoma, papillary meningioma, choroid plexus papilloma, and metastatic papillary carcinoma. (wikipedia.org)
  • In one case, recurrence and metastases were recognized rather rapidly, only 3 months after the first excision. (thedoctorsdoctor.com)
  • There have been no reports of early recurrence or metastases, especially the latter. (thedoctorsdoctor.com)
  • Even after radical excision which is the standard management, local recurrence and metastases are frequent. (egms.de)
  • There is so far no evidence of metastases or local recurrence. (wikipedia.org)
  • Apart from other prognostic factors obesity increased the risk of recurrence and influenced disease-free survival in breast cancer patients without lymph node metastases. (termedia.pl)
  • Progression can be with local recurrence or distant metastases. (disabled-world.com)
  • Despite systemic chemotherapy, OS may give rise to local recurrences and metastases. (eurekaselect.com)
  • Repeated 18F-FDG PET suggested left lower limb recurrence, without other metastases. (endocrine-abstracts.org)
  • These tumors are designated as atypical meningiomas (WHO grade II, MII) ( 2 ) and show a tendency for local tumor recurrence even after complete resection ( 3 ). (pnas.org)
  • Primary therapy for SFT is wide surgical resection to reduce local tumor recurrence. (ctsnet.org)
  • After surgical violation, the PPF will always appear abnormal on MR images, and the expected imaging findings must be recognized to avoid the misdiagnosis of tumor recurrence. (ajnr.org)
  • Predicting biochemical recurrence and prostate cancer specific mortality after radical prostatectomy: comparison of six prediction models in a cohort of screen and clinically detected prostate cancer patients. (urotoday.com)
  • To perform a comparison and external validation of three models predicting biochemical recurrence (BCR) and three models predicting prostate cancer specific mortality (PCSM) in a screening setting, i. (urotoday.com)
  • Stomach cancer is a high mortality neoplasm. (cun.es)
  • The insertion of a pericardial catheter for prolonged drainage or pericardial sclerosis provides more definitive freedom from recurrence, without a significant increase in periprocedural mortality or morbidity. (acc.org)
  • Neoplasm Recurrence, Local" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • There is a consensus that synthetic mesh must be avoided in infected operations, and the alternatives to using synthetic mesh, such as component separation techniques and biologic mesh, present disappointing results with expressive wound infection and hernia recurrence rates. (bioportfolio.com)
  • FDG-PET/MRI is a valuable tool in the diagnosis and staging of pelvic recurrence in patients with rectal cancer. (springer.com)
  • An understanding of the approaches used for staging of musculoskeletal neoplasms requires knowledge of their biologic behavior and natural history. (healio.com)
  • Preoperative PLT, serum sodium, and tumor staging were independent risk factors for local recurrence. (medscimonit.com)
  • Access the latest scientific research and medical evidence related to Neoplasm Recurrence, Local treatment, diagnosis and symptoms, quickly and easily with doctorAsyou. (doctorasyou.com)
  • To determine the value of 18 F-FDG-PET/MRI in the diagnosis and management of patients with pelvic recurrence of rectal cancer. (springer.com)
  • In recent years the PET/CT with choline has changed the handling of prostate cancer in Europe, and it is commonly used for initial stratification or for the diagnosis of a biochemical recurrence, although it does not lack limitations. (urotoday.com)
  • Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
  • The study also reported that recurrence risk factors for these lesions included positive and uncertain resection margins, as well as younger age at diagnosis. (medscape.com)
  • Biopsy is required to confirm the diagnosis and to histologically characterize the neoplasm. (oncologynurseadvisor.com)
  • The differential diagnosis is largely that of other benign and malignant neoplasms that arise in these locations. (oralcancerfoundation.org)
  • The first investigation aims to build the population-based incidence of sarcoma in a two-year period, using the new 2002 WHO classification and the "second opinion" given by an expert regional pathologist on the initial diagnosis by a local pathologist. (ebscohost.com)
  • With the current emphasis on limb salvage procedures for local control of tumors, and with the addition of adjunctive therapy, the ability to classify and stage these unusual tumors is important in determining prognosis and treatment. (healio.com)
  • We have studied the influence of some factors such as age, sex, location of tumour in the cerebellum, amount of surgical resection and histological variants on survival and recurrence of the disease. (biomedsearch.com)
  • Two patients underwent resection and had histologically proven pelvic recurrence without showing suspicious findings on FDG-PET/MRI. (springer.com)
  • Even-Sapir E, Parag Y, Lerman H et al (2004) Detection of recurrence in patients with rectal cancer: PET/CT after abdominoperineal or anterior resection. (springer.com)
  • Management of pleural recurrence after curative resection of thymoma. (curehunter.com)
  • From the pleural recurrence resection, the overall 5- and 10-year survivals are 43.1% and 25.8%, respectively. (curehunter.com)
  • Purpose: We studied whether a single instillation of epirubicin after transurethral bladder tumor resection would influence the interval to and size of the first recurrence. (diva-portal.org)
  • Regardless of treatment, the rate of recurrence of GCT of small bones trends toward the higher end of the ranges for all bones: 27-65% after curettage alone, 12-34% after curettage with adjuvants, and 0-12% after complete resection [ 2 , 6 , 8 - 11 ]. (hindawi.com)
  • We report a case of a second recurrence of giant cell tumor of the first metatarsal in a female who was treated successfully with wide resection and iliac crest arthrodesis. (hindawi.com)
  • References in the literature support the role of resection margins as a predictor of local recurrence. (springer.com)
  • The aim of this study was to characterize patterns of local progression following resection for pancreatic intraductal papillary mucinous neoplasms (IPMN) using targeted next-generation sequencing (NGS). (ovid.com)
  • In parallel, clinical and pathological characteristics of 260 patients who underwent resection of noninvasive IPMN were reviewed to identify risk factors associated with local progression. (ovid.com)
  • We identified 3 mechanisms underlying local progression in the remnant pancreas: (1) residual microscopic disease at the resection margin, (2) intraparenchymal spread of neoplastic cells, leading to an anatomically separate but genetically related recurrence, and (3) multifocal disease with genetically distinct lesions. (ovid.com)
  • Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. (medscape.com)
  • Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
  • Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands. (medscape.com)
  • Squamous odontogenic tumors (SOTs) are very rare benign locally infiltrative odontogenic neoplasms of epithelial origin. (wikipedia.org)
  • Giant cell tumor of bone is a benign, aggressive neoplasm commonly arising in the femur, tibia, and distal radius and less commonly in the hands and feet. (hindawi.com)
  • Giant cell tumor of bone (GCTB) is a benign, aggressive neoplasm with metastatic and high local recurrence potential. (hindawi.com)
  • The lesions are benign but incomplete biopsy/removal may result in local recurrence. (oncologynurseadvisor.com)
  • Desmoid tumors are benign mesenchymal tumors with a strong tendency for local recurrence after surgery. (ufl.edu)
  • The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the table below. (medscape.com)
  • Six months following the index surgery, she had a recurrence treated with repeat curettage, liquid nitrogen local adjuvant, and placement of bone substitute graft. (hindawi.com)
  • Due to a high rate of local recurrence, radiosynoviorthesis (RSO) is used as an adjuvant method in many cases. (springer.com)
  • The aim of this study was to compare local recurrence (LR) rates after surgical synovectomy with and without adjuvant RSO. (springer.com)
  • Adjuvant therapy is tailored based on the molecular profile of the neoplasm and can include aromatase inhibitors, anti-estrogen, anti-progesterone (or a combination of antiestrogen and antiprogesterone), and HER2 neu suppression therapy. (hindawi.com)
  • Very low-quality evidence does not allow drawing conclusions on activated charcoal for preoperative localization of thyroid cancer recurrence, although it might be useful in identifying deep and difficult access lesions in patients with prior surgery in the relapsed area. (york.ac.uk)
  • It continues to have a high recurrence rate after surgery in the form of local relapse or occult micrometastatic disease. (cun.es)
  • Local recurrence after surgery has been described in 1 % - 5 % of cases, and malignant evolution in 2 % - 9% of cases. (scirp.org)
  • Further locoregional failure represents the major failure pattern, and the proportion of patients who had further local, regional, and both locoregional failures were 16%, 9%, and 53%, respectively. (nih.gov)
  • When early tumor regrowths (up to and including the initial 12 months of follow-up) and late recurrences were considered together, 28 patients (31%) experienced local recurrence (median follow-up time, 60 months). (osti.gov)
  • In 4 patients, local re-recurrence developed after Watch and Wait plus salvage. (osti.gov)
  • Thirteen patients (14%) experienced systemic recurrence. (osti.gov)
  • Conclusions: Local recurrence may develop in 31% of patients with initial cCR when early regrowths (≤12 months) and late recurrences are grouped together. (osti.gov)
  • Only the histological type has a statistically significant influence on survival and recurrence: we have found that patients presenting classic medulloblastoma have a long survival and a long relapse-free interval. (biomedsearch.com)
  • Four of 6 patients with MDTs who died had local recurrence. (uptodate.com)
  • METHODS: The charts of 111 patients with local recurrence of oral or oropharyngeal squamous cell carcinomas were retrospectively analyzed. (usp.br)
  • Patients treated with breast conserving therapy will be followed for recurrence in the ipsilateral or contralateral breast by physical examination every six month and imaging studies performed annually. (knowcancer.com)
  • a descriptive, observational and prospective study was carried out on the "disease free interval " in 68 patients after having surgical treatment of colon cancer in ¨Saturnino Lora¨ Teaching Provincial Hospital of Santiago de Cuba from 1990 to 2008 that presented tumorous recurrence, diagnosed in outpatient department by means of a posoperative follow up outline during a five year period or more. (sld.cu)
  • It is imposed to increase the surveillance of the operated patients due to colon cancer with healing intention in the first 2 years of posoperative follow up, because during that biennium most of the recurrences take place in any localization. (sld.cu)
  • Fifteen patients had a thymus-related syndrome (in 13 patients it resulted myasthenia gravis ), and in 11 patients it improved or remitted after treatment of the pleural recurrence. (curehunter.com)
  • Repeat operation on patients with thymoma pleural recurrences is feasible and safe. (curehunter.com)
  • Multimodal therapy increased survival among uterine CS patients, but the recurrence rate remained high. (curehunter.com)
  • Among patients with a pCR, patients with TNBC had similar recurrence-free survival (RFS) and overall survival (OS) to patients without TNBC. (nih.gov)
  • Recurrence-free survival in patients with breast cancer without a pathologic complete response after neoadjuvant treatment with gemcitabine plus docetaxel alternating with vinorelbine plus epirubicin according to triple-negative status. (nih.gov)
  • Results: Of 155 evaluable patients in the epirubicin group 79 (51.0%) had recurrence compared to 95 of 152 (62.5%) in the placebo group (p = 0.04). (diva-portal.org)
  • Of 79 patients with recurrence in the epirubicin arm 33 (42.9%) vs 29 (31.5%) of 95 in the placebo arm had larger (more than 5 mm) first recurrences (p = 0.12). (diva-portal.org)
  • Approximately half of the patients with first recurrences were treated as outpatients and the other half spent a total of 145 days in the hospital with no difference between the groups. (diva-portal.org)
  • Conclusions: We confirmed the results of previous studies showing that 8.5 patients must be treated with a single instillation to prevent I recurrence. (diva-portal.org)
  • Method: Local recurrence and survival rates of 4153 patients registered 1995-1997 in the Swedish Rectal Cancer Registry were analysed. (diva-portal.org)
  • Using NGS, we identify distinct mechanisms for development of metachronous or synchronous neoplasms in patients with IPMN. (ovid.com)
  • Patients with a primary IPMN with HGD or with positive family history are at an increased risk to develop subsequent high-risk neoplasms in the remnant pancreas. (ovid.com)
  • Analyzes the clinicoradiographic, microscopic and immunophenotypic features of 21 tumors from 13 patients with mesenchymal chondrosarcoma neoplasms. (ebscohost.com)
  • Ameloblastoma is an odontogenic neoplasm with local invasiveness and high recurrence. (jove.com)
  • Purpose: To review the risk of local recurrence and impact of salvage therapy after Watch and Wait for rectal cancer with complete clinical response (cCR) after chemoradiation therapy (CRT). (osti.gov)
  • Metabolic information obtained from PET coupled with excellent soft tissue contrast from MRI could facilitate detection of rectal cancer recurrence and assist in treatment planning. (springer.com)
  • In recent decades, the local treatment of penile cancer has focused primary on the removal of the primary tumor. (springer.com)
  • The aim of this article is to highlight current standards in the local treatment of penile cancer. (springer.com)
  • Aim: Despite advances in rectal cancer treatment, local recurrence (LR) remains a significant problem. (diva-portal.org)
  • Only two clinical practice guidelines suggest its potential use in thyroid cancer recurrence and no coverage policies were found mentioning this technology. (york.ac.uk)
  • Breast cancer is the most frequent malignant neoplasm in women and it is a leading cause of death from cancer in Poland. (termedia.pl)
  • The treatment of the primary tumor should be based on the stage and the local extent and size of the tumor. (springer.com)
  • Of those 9 recurrences, 3 (17%) were seen in primary disease, 6 (32%) in already recurring cases (n.s. (springer.com)
  • They account for 15-25% of primary intracranial and intraspinal neoplasms and their annual incidence has been estimated to be about 6 per 100,000 individuals ( 1 ). (pnas.org)
  • Osteosarcoma (OS) is the second most common primary malign bone neoplasm after multiple myeloma. (eurekaselect.com)
  • Primary adrenal leiomyosarcoma is an infrequent malignant neoplasm arising from adrenal veins. (elsevier.es)
  • The predetermined primary endpoint was recurrence of pericardial effusion. (acc.org)
  • The primary endpoint of MPE recurrence was pooled for each intervention using the random-effects model. (acc.org)
  • Esthesioneuroblastoma (ENB) is a very rare malignant neoplasm arising from the olfactory epithelium which is recognized for its propensity for local recurrence and distant dissemination. (hu-berlin.de)
  • This systemic review and pooled analysis suggests that while pericardiocentesis can be safely performed with appropriate imaging guidance to provide immediate symptomatic relief, it has a relatively high recurrence rate compared with combined procedures. (acc.org)
  • Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue neoplasm that most commonly appears in the limbs, typically affecting children and young adults. (thejns.org)
  • Dermatofibrosarcoma protuberans is an uncommon soft tissue neoplasm. (ebscohost.com)
  • Medulloblastoma in adulthood: prognostic factors influencing survival and recurrence. (biomedsearch.com)
  • Since then, there have been numerous advances in the identification of unique biomarkers associated with some myeloid neoplasms and acute leukemias, largely derived from gene expression analysis and next-generation sequencing that can significantly improve the diagnostic criteria as well as the prognostic relevance of entities currently included in the WHO classification and that also suggest new entities that should be added. (bloodjournal.org)
  • 1 ] Although some thymoma histologic types are more likely to be invasive and clinically aggressive, treatment outcome and the likelihood of recurrence appear to correlate more closely with the invasive/metastasizing properties of the tumor cells. (healthlinkbc.ca)
  • Salvage therapy is possible in ≥90% of recurrences, leading to 94% local disease control, with 78% organ preservation. (osti.gov)
  • Local excision is recommended as initial therapy and also for recurrences. (ovid.com)
  • Twenty-four months after initiation of proton therapy, the patient is without clinical or radiographic evidence of disease recurrence. (ufl.edu)
  • This neoplasm is associated with a high risk of local recurrence and regional lymph node involvement. (endocrine-abstracts.org)
  • [ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. (medscape.com)
  • Advanced tumors may present with pain and/or nerve paralysis, for this neoplasm has a propensity to invade peripheral nerves. (oralcancerfoundation.org)
  • Unfortunately, there is no standard treatment for pleural recurrence. (curehunter.com)
  • Solitary fibrous tumors (SFT) are rare neoplasms representing less than 5% of pleural tumors (1, 2). (ctsnet.org)
  • 5% of pleural neoplasms. (dovepress.com)
  • Mesenchymal Chondrosarcoma: A Small Cell Neoplasm with Polyphenotypic Differentiation. (ebscohost.com)
  • Recidiva local de carcinomas epidermóides da boca e orofaringe: estudo de variáveis. (usp.br)
  • CASUÍSTICA E MÉTODOS: Os prontuários de 111 pacientes portadores de recorrência local de carcinomas epidermóides de boca e orofaringe foram analisados de forma retrospectiva. (usp.br)
  • 3 ] Thymic carcinomas are rare and have been reported to account for only 0.06% of all thymic neoplasms. (healthlinkbc.ca)
  • The local recurrence of a neoplasm following treatment. (wakehealth.edu)
  • Treatment included wide local or radical excision and local recurrences were not reported. (thedoctorsdoctor.com)
  • Treatment is by simple enucleation and local curettage, and recurrence is rare. (wikipedia.org)
  • ABSTRACT: In the treatment of musculoskeletal neoplasms, preservation of limb function and prolongation of survival have improved over the past decade. (healio.com)
  • Local treatment methods such as TACE and percutaneous ethanol injection may have poor efficacy because of abundant interfibrillar substances and the poor blood supply found in cHCC-CC [ 7 ]. (biomedcentral.com)
  • Improved characterization and standardization of morphological features aiding in the differentiation of disease groups, particularly of the BCR-ABL1 − myeloproliferative neoplasms (MPNs), has increased the reliability and reproducibility of diagnoses. (bloodjournal.org)
  • It is essential to review this area on both pre- and posttreatment studies of head and neck malignancies to assess local extent of disease or recurrence and perineural tumor spread. (ajnr.org)
  • A study from the Netherlands, by Valstar et al, found an overall 20-year recurrence rate for salivary gland pleomorphic adenomas of 6.7%, with the first recurrence arising at a median of 7 years. (medscape.com)
  • Those located in the minor salivary glands had a lower recurrence risk than did pleomorphic adenomas in the parotid glands. (medscape.com)
  • The term, thymoma, is customarily used to describe neoplasms that show no overt atypia of the epithelial component. (healthlinkbc.ca)