Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Neoplasms containing cyst-like formations or producing mucin or serum.
Tumors or cancer of the SKIN.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Tumors or cancers of the KIDNEY.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Tumors or cancer of the THYROID GLAND.
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
DNA present in neoplastic tissue.
Tumors or cancer of the LUNG.
Tumors or cancer of the PAROTID GLAND.
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.
Tumors or cancer of the APPENDIX.
Tumors or cancer of the LIVER.
A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Tumors or cancer of the ENDOCRINE GLANDS.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.
Tumors or cancer of the EYE.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the NOSE.
Tumors or cancer of the SALIVARY GLANDS.
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.
Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
A benign epithelial tumor with a glandular organization.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Tumors or cancer of the UTERUS.
Tumors or cancer of the INTESTINES.
Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.
A general term for various neoplastic diseases of the lymphoid tissue.
Tumors or cancer located in bone tissue or specific BONES.
Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.
Neoplasms composed of more than one type of neoplastic tissue.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Tumors or cancer of the MANDIBLE.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Tumors or cancer of the BILE DUCTS.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the THYMUS GLAND.
Tumors or cancer of the SPLEEN.
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)
Tumors or cancer of the COLON.
Cancer or tumors of the MAXILLA or upper jaw.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Tumors or cancer of the anal gland.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
Neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
Tumors or cancer of the DUODENUM.
Tumors or cancers of the ADRENAL CORTEX.
Tumors or cancer of the MOUTH.
Tumors or cancer of the MEDIASTINUM.
Tumors or cancer of the TONGUE.
Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).
Tumors or cancer of the STOMACH.
Tumors or cancer of the URINARY BLADDER.
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Tumors or cancer of the VAGINA.
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.
Experimentally induced tumors of the LIVER.
A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A malignant epithelial tumor with a glandular organization.
Clonal myeloid disorders that possess both dysplastic and proliferative features but are not properly classified as either MYELODYSPLASTIC SYNDROMES or MYELOPROLIFERATIVE DISORDERS.
Surgical removal of the pancreas. (Dorland, 28th ed)
Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)
Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.
Tumors or cancer of the PARANASAL SINUSES.
Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.
Tumors or cancer of the human BREAST.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
Neoplasms of the bony orbit and contents except the eyeball.
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
A benign tumor composed of fat cells (ADIPOCYTES). It can be surrounded by a thin layer of connective tissue (encapsulated), or diffuse without the capsule.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as BRAIN NEOPLASMS; DUODENAL NEOPLASMS; LIVER NEOPLASMS; etc.
Tumors or cancer of the BRONCHI.
Tumors or cancer of the PERITONEUM.
Distinctive neoplastic disorders of histiocytes. Included are malignant neoplasms of MACROPHAGES and DENDRITIC CELLS.
Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.
Neoplasms of the bony part of the skull.
Tumors or cancer of the VULVA.
Neoplasms composed of neuroepithelial cells, which have the capacity to differentiate into NEURONS, oligodendrocytes, and ASTROCYTES. The majority of craniospinal tumors are of neuroepithelial origin. (From Dev Biol 1998 Aug 1;200(1):1-5)
Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).
Tumors or cancer of the LIP.
A benign tumor of fibrous or fully developed connective tissue.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Tumors or cancer of the ADRENAL GLANDS.
Tumors or cancer of the pelvic region.
Tumors or cancer of the gallbladder.
The local implantation of tumor cells by contamination of instruments and surgical equipment during and after surgical resection, resulting in local growth of the cells and tumor formation.
Neoplasms composed of fibrous and epithelial tissue. The concept does not refer to neoplasms located in fibrous tissue or epithelium.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Neoplasms composed of connective tissue, including elastic, mucous, reticular, osseous, and cartilaginous tissue. The concept does not refer to neoplasms located in connective tissue.
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
A clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets.
RNA present in neoplastic tissue.
Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)
A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
Tumors or cancer of the CECUM.
A malignant disease of the B-LYMPHOCYTES in the bone marrow and/or blood.
A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
Tumors or cancer of the DIGESTIVE SYSTEM.
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)
Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
Liquid material found in epithelial-lined closed cavities or sacs.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
A benign epithelial tumor of the LIVER.
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.
A benign, non-neoplastic, usually self-limiting epithelial lesion closely resembling squamous cell carcinoma clinically and histopathologically. It occurs in solitary, multiple, and eruptive forms. The solitary and multiple forms occur on sunlight exposed areas and are identical histologically; they affect primarily white males. The eruptive form usually involves both sexes and appears as a generalized papular eruption.
A condition characterized by poorly-circumscribed gelatinous masses filled with malignant mucin-secreting cells. Forty-five percent of pseudomyxomas arise from the ovary, usually in a mucinous cystadenocarcinoma (CYSTADENOCARCINOMA, MUCINOUS), which has prognostic significance. Pseudomyxoma peritonei must be differentiated from mucinous spillage into the peritoneum by a benign mucocele of the appendix. (Segen, Dictionary of Modern Medicine, 1992)
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Tumor or cancer of the MALE GENITALIA.
Intracranial tumors originating in the region of the brain inferior to the tentorium cerebelli, which contains the cerebellum, fourth ventricle, cerebellopontine angle, brain stem, and related structures. Primary tumors of this region are more frequent in children, and may present with ATAXIA; CRANIAL NERVE DISEASES; vomiting; HEADACHE; HYDROCEPHALUS; or other signs of neurologic dysfunction. Relatively frequent histologic subtypes include TERATOMA; MEDULLOBLASTOMA; GLIOBLASTOMA; ASTROCYTOMA; EPENDYMOMA; CRANIOPHARYNGIOMA; and choroid plexus papilloma (PAPILLOMA, CHOROID PLEXUS).
Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
Tumors of the iris characterized by increased pigmentation of melanocytes. Iris nevi are composed of proliferated melanocytes and are associated with neurofibromatosis and malignant melanoma of the choroid and ciliary body. Malignant melanoma of the iris often originates from preexisting nevi.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Primary urethral carcinomas are rare and typically of squamous cells. Urethral carcinoma is the only urological malignancy that is more common in females than in males.
Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
A family of mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. These cells do not have a normal anatomic homolog. (From Fletcher CDM, et. al., World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone, 2002).
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A mixed mesenchymal tumor composed of two or more mesodermal cellular elements not commonly associated, not counting fibrous tissue as one of the elements. Mesenchymomas are widely distributed in the body and about 75% are malignant. (Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
Tumors or cancer of the RECTUM.
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.
Tumors or cancer of the ESOPHAGUS.
Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.
Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A usually benign tumor made up predominantly of myoepithelial cells.
Tumors or cancer of the PROSTATE.
Tumors of cancer of the EYELIDS.
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
Benign and malignant tumors of the HYPOTHALAMUS. Pilocytic astrocytomas and hamartomas are relatively frequent histologic types. Neoplasms of the hypothalamus frequently originate from adjacent structures, including the OPTIC CHIASM, optic nerve (see OPTIC NERVE NEOPLASMS), and pituitary gland (see PITUITARY NEOPLASMS). Relatively frequent clinical manifestations include visual loss, developmental delay, macrocephaly, and precocious puberty. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2051)
A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Tumors or cancer of the MAXILLARY SINUS. They represent the majority of paranasal neoplasms.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Glycopeptides from the surgace of human neuroblastoma cells. (1/19029)

Glycopeptides suggesting a complex oligosaccharide composition are present on the surface of cells from human neuroblastoma tumors and several cell lines derived from the tumors. The glycopeptides, labeled with radioactive L-fucose, were removed from the cell surface with trypsin, digested with Pronase, and examined by chromatography on Sephadex G-50. Human skin fibroblasts, brain cells, and a fibroblast line derived from neuroblastoma tumor tissue show less complex glycopeptides. Although some differences exist between the cell lines and the primary tumor cells, the similarities between these human tumors and animal tumors examined previously are striking.  (+info)

Diphtheria toxin effects on human cells in tissue culture. (2/19029)

HeLa cells exposed to a single sublethal concentration of diphtheria toxin were found to have diminished sensitivity when subsequently reexposed to the toxin. Three cells strains exhibiting toxin resistance were developed. In the cells that had previously been exposed to toxin at 0.015 mug/ml, 50% inhibition of protein synthesis required a toxin concentration of 0.3 mug/ml, which is more than 10 times that required in normal HeLa cells. There appears to be a threshold level of diphtheria toxin action. Concentrations of toxin greater than that required for 50% inhibition of protein synthesis (0.01 mug/ml) are associated with cytotoxicity, whereas those below this concentration may not be lethal. Several established human cell lines of both normal and neoplastic origin were tested for their sensitivity to the effects of the toxin. No special sensitivity was observed with the cells of tumor origin. Fifty % inhibition of protein synthesis of HeLa cells was achieved with diphtheria toxin (0.01 mug/ml) as compared to the normal human cell lines tested (0.03 and 0.5 mug/ml) and a cell line derived from a human pancreatic adenocarcinoma (0.2 mug/ml). A human breast carcinoma cell line showed a maximum of 45% inhibition of protein synthesis. This required a diphtheria toxin concentration of 5 mug/ml. These results suggest that different human cell lines show wide variation in their sensitivity to the toxin.  (+info)

The effects of androgens and antiandrogens on hormone-responsive human breast cancer in long-term tissue culture. (3/19029)

We have examined five human breast cancer cell lines in continuous tissue culture for androgen responsiveness. One of these cell lines shows a 2- to 4-fold stimulation of thymidine incorporation into DNA, apparent as early as 10 hr following androgen addition to cells incubated in serum-free medium. This stimulation is accompanied by an acceleration in cell replication. Antiandrogens [cyproterone acetate (6-chloro-17alpha-acetate-1,2alpha-methylene-4,6-pregnadiene-3,20-dione) and R2956 (17beta-hydroxy-2,2,17alpha-trimethoxyestra-4,9,11-triene-1-one)] inhibit both protein and DNA synthesis below control levels and block androgen-mediated stimulation. Prolonged incubation (greater than 72 hr) in antiandrogen is lethal. The MCF- cell line contains high-affinity receptors for androgenic steroids demonstrable by sucrose density gradients and competitive protein binding analysis. By cross-competition studies, androgen receptors are distinguishable from estrogen receptors also found in this cell line. Concentrations of steroid that saturate androgen receptor sites in vitro are about 1000 times lower than concentrations that maximally stimulate the cells. Changes in quantity and affinity of androgen binding to intact cells at 37 degrees as compared with usual binding techniques using cytosol preparation at 0 degrees do not explain this difference between dissociation of binding and effect. However, this difference can be explained by conversion of [3H]-5alpha-dihydrotestosterone to 5alpha-androstanediol and more polar metabolites at 37 degrees. An examination of incubation media, cytoplasmic extracts and crude nuclear pellets reveals probable conversion of [3H]testosterone to [3H]-5alpha-dihydrotestosterone. Our data provide compelling evidence that some human breast cancer, at least in vitro, may be androgen dependent.  (+info)

Transformation mediated by RhoA requires activity of ROCK kinases. (4/19029)

BACKGROUND: The Ras-related GTPase RhoA controls signalling processes required for cytoskeletal reorganisation, transcriptional regulation, and transformation. The ability of RhoA mutants to transform cells correlates not with transcription but with their ability to bind ROCK-I, an effector kinase involved in cytoskeletal reorganisation. We used a recently developed specific ROCK inhibitor, Y-27632, and ROCK truncation mutants to investigate the role of ROCK kinases in transcriptional activation and transformation. RESULTS: In NIH3T3 cells, Y-27632 did not prevent the activation of serum response factor, transcription of c-fos or cell cycle re-entry following serum stimulation. Repeated treatment of NIH3T3 cells with Y-27632, however, substantially disrupted their actin fibre network but did not affect their growth rate. Y-27632 blocked focus formation by RhoA and its guanine-nucleotide exchange factors Dbl and mNET1. It did not affect the growth rate of cells transformed by Dbl and mNET1, but restored normal growth control at confluence and prevented their growth in soft agar. Y-27632 also significantly inhibited focus formation by Ras, but had no effect on the establishment or maintenance of transformation by Src. Furthermore, it significantly inhibited anchorage-independent growth of two out of four colorectal tumour cell lines. Consistent with these data, a truncated ROCK derivative exhibited weak ability to cooperate with activated Raf in focus formation assays. CONCLUSIONS: ROCK signalling is required for both the establishment and maintenance of transformation by constitutive activation of RhoA, and contributes to the Ras-transformed phenotype. These observations provide a potential explanation for the requirement for Rho in Ras-mediated transformation. Moreover, the inhibition of ROCK kinases may be of therapeutic use.  (+info)

Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. (5/19029)

The Id subfamily of helix-loop-helix (HLH) proteins plays a fundamental role in the regulation of cellular proliferation and differentiation. Id proteins are thought to inhibit differentiation mainly through interaction with other HLH proteins and by blocking their DNA-binding activity. Members of the ternary complex factor (TCF) subfamily of ETS-domain proteins have key functions in regulating immediate-early gene expression in response to mitogenic stimulation. TCFs form DNA-bound complexes with the serum response factor (SRF) and are direct targets of MAP kinase (MAPK) signal transduction cascades. In this study we demonstrate functional interactions between Id proteins and TCFs. Ids bind to the ETS DNA-binding domain and disrupt the formation of DNA-bound complexes between TCFs and SRF on the c-fos serum response element (SRE). Inhibition occurs by disrupting protein-DNA interactions with the TCF component of this complex. In vivo, the Id proteins cause down-regulation of the transcriptional activity mediated by the TCFs and thereby block MAPK signalling to SREs. Therefore, our results demonstrate a novel facet of Id function in the coordination of mitogenic signalling and cell cycle entry.  (+info)

Human papillomavirus DNA in adenosquamous carcinoma of the lung. (6/19029)

AIM: To investigate the presence of human papillomavirus (HPV) DNA in adenosquamous carcinoma of the lung--which is relatively common in Okinawa but not in mainland Japan--and examine its histological features. METHODS: Of 207 cases where primary lung cancers were surgically removed between January 1995 and June 1997 in Okinawa, 23 were adenosquamous carcinoma. HPV was detected by non-isotopic in situ hybridisation (NISH) and polymerase chain reaction (PCR) amplification with primers specific for E6 and E7 regions of the HPV genome. PCR products were analysed by Southern blotting. Immunohistochemical determination of high molecular weight cytokeratin (HMC) and involucrin was also carried out. RESULTS: 18 cases were positive for HPV DNA by PCR and NISH. HPV types 6, 11, 16, and 18 were found. Seven cases were dual positive for different types of HPV. Using NISH, HPV was also found in the squamous cell components and in neighbouring enlarged adenocarcinoma cells. The HMC and involucrin were demonstrated immunohistochemically in the same areas. CONCLUSIONS: HPV DNA was found in a high proportion (78.3%) of adenosquamous carcinomas in Okinawa, a region where HPV has previously been shown to be prevalent in squamous cell carcinoma of the lung. The adenocarcinoma cells adjacent to the squamous cell carcinoma component were enlarged and positive for HPV, HMC, and involucrin. This is thought to indicate the transition from adenocarcinoma to squamous cell carcinoma.  (+info)

Immunohistochemical expression of mdm2 and p21WAF1 in invasive cervical cancer: correlation with p53 protein and high risk HPV infection. (7/19029)

AIM: To investigate the immunocytochemical staining pattern of mdm2 and p21WAF1 proteins in invasive cervical cancer and to determine its relation with the expression of p53 and with the high risk HPV infection. METHODS: Immunocytochemistry for p53, mdm2, and p21WAF1 was performed in 31 paraffin embedded sections of invasive cervical cancer. The results were assessed by image analysis, evaluating for each protein the optical density of the immunostained area, scored as percentage of the total nuclear area. The presence of high risk human papillomavirus (HPV) infection was detected by using the polymerase chain reaction. RESULTS: Immunostaining for both mdm2 and p21WAF1 was correlated with p53 expression; however, the correlation between p53 and mdm2 (R = 0.49; p < 0.01) was more significant than between p53 and p21WAF1 (R = 0.31; p < 0.05); the less stringent correlation between p53 and p21WAF1 might reflect the p53 independent mechanisms of p21WAF1 induction. Similar average levels of p53, mdm2, and p21WAF1 immunostaining were found in the presence or absence of high risk HPV-DNA, without significant differences between the two groups. CONCLUSIONS: These data suggest that mdm2 and p21WAF1 proteins are expressed in invasive cervical cancer and that their immunocytochemical staining pattern is not abrogated by the presence of high risk HPV genomic sequences.  (+info)

Expression of extracellular matrix proteins in cervical squamous cell carcinoma--a clinicopathological study. (8/19029)

AIM: To evaluate the intracellular and peritumoral expression of matrix proteins in squamous cell carcinoma of the uterine cervix using immunohistochemistry. METHODS: 71 squamous cell carcinomas and 10 controls were stained for laminin, fibronectin, and collagen IV. Cytoplasmic staining in tumour cells and peritumoral deposition of matrix proteins were evaluated. The association between staining results and patient age, tumour stage, histological grade, and survival was studied. RESULTS: Positive cytoplasmic staining for laminin, fibronectin, and collagen IV was observed in 17 (23.9%), 27 (38%), and 10 (14.1%) cases, respectively. Staining for laminin was most pronounced in the invasive front of tumour islands, while for fibronectin and collagen IV it appeared to be diffuse. Peritumoral staining for laminin and collagen IV was detected in 12 cases (16.9%). Early stage (Ia1-Ia2) tumours were uniformly negative for all three proteins. Cytoplasmic staining for laminin correlated with positive staining for fibronectin and collagen IV, and with the presence of a peritumoral deposition of collagen IV and laminin. There was no correlation with any of the three markers between staining results and patient age, stage, grade, or survival. CONCLUSIONS: Expression of extracellular matrix proteins in some cervical squamous cell carcinomas might reflect the enhanced ability of these tumours to modify the peritumoral stroma. This ability seems to be absent in early stage tumours. The correlation between intracytoplasmic and peritumoral expression of matrix proteins supports the evidence of their synthesis by tumour cells. However, this property did not correlate with disease outcome in this study.  (+info)

The major factor in the morbidity and mortality of cancer patients is metastasis. There exists a relative lack of specific therapeutic approaches to control metastasis, and this is a fruitful area for
This gene is a member of the MAGED gene family. It is expressed only in brain and ovary, and some transcript variants of this gene are specifically expressed in glioma cells. This gene is clustered with other MAGED genes on chromosome Xp11. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011] ...
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Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (TUMOR MARKERS, BIOLOGICAL) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm ...
DB-ID: Database ID of variant, grouping multiple observations of the same variant together, starting with the HGNC gene symbol, followed by an underscore (_) and a six digit number (e.g. DMD_012345). _000000 is used for variants where DNA was not analysed (change predicted from RNA analysis), variants seen in animal models or variants not seen in humans but functionally tested in vitro ...
Title: Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2). VOLUME: 11 ISSUE: 7. Author(s):Zhanglin Ni, Zsolt Bikadi, Mark F. Rosenberg and Qingcheng Mao. Affiliation:Department of Pharmaceutics,School of Pharmacy, University of Washington, Health Science Building H272, 1959 NE Pacific Street , Seattle, Washington 98195-7610, USA.. Keywords:Breast cancer resistance protein, BCRP, ATP-binding cassette transporter, ABCG2, multidrug resistance, drug disposition, homology model, mutation analysis, BCRP/ABCG2, mitoxantrone-resistant human cancer cell lines, MXR, human placenta, ABCP, nucleotide binding domains, membrane spanning domains, MSDs, affinity constants, SAR, QSAR, flavonoids, tamoxifen analogues, cyclindependent kinase inhibitors, tariquidar analogues, FTC analogues, 2D-QSAR, CoMFA, CoMSIA, 3D-QSAR, MIFs, HEK cells, Pichia pastoris, Lactococcus lactis, fluorescence resonance energy transfer v, MODELLER. Abstract: The human breast cancer resistance protein ...
The KOMP Repository Collection is located at the MMRRC at the University of California, Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
The human fragile histidine triad (FHIT) gene encodes a protein that is involved in purine metabolism. Aberrant transcripts from this gene, typically from carcinogen-induced damage and translocations, have been found in about half of all esophageal, stomach, and colon carcinomas. Although the exact function of human FHIT protein is not known, animal studies have demonstrated its role as a tumor suppressor in breast and lung cancers. FHIT protein is also known as bis(5-adenosyl)-triphosphatase, diadenosine 5,5-P1,P3-triphosphate hydrolase, AP3A hydrolase, AP3Aase, dinucleosidetriphosphatase, and FRA3B.. ...
The human fragile histidine triad (FHIT) gene encodes a protein that is involved in purine metabolism. Aberrant transcripts from this gene, typically from carcinogen-induced damage and translocations, have been found in about half of all esophageal, stomach, and colon carcinomas. Although the exact function of human FHIT protein is not known, animal studies have demonstrated its role as a tumor suppressor in breast and lung cancers. FHIT protein is also known as bis(5-adenosyl)-triphosphatase, diadenosine 5,5-P1,P3-triphosphate hydrolase, AP3A hydrolase, AP3Aase, dinucleosidetriphosphatase, and FRA3B.. ...
Division of Molecular Biotherapy [Y. I., M. N., K. K., S. T., E. I., Y. S.] and Division of Experimental Chemotherapy [T. T.], Cancer Chemotherapy Center, and Department of Molecular Diagnosis [Y. M.], Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 170-8455, and Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032 [T. T.], ...
Objective(s) The growing trend of research demonstrates that dynamic expression of two metastasis repressor classes (metastasis suppressor genes and anti-metastatic miRNA) has a close relationship with tumor invasion and metastasis. Using different strategies, it was revealed that cellular levels of miR-31 and Breast cancer Metastasis Suppressor1 (BRMS1) protein, which are among the most significant modulators of metastasis, have a correlation with the cells capability for invading and metastasizing; cells containing higher levels of miR-31 or BRMS1 were less metastatic. This project was carried out to determine whether the combinations of miR-31 and BRMS1 genes are able to enhance the capability of repressing the claudin-low breast cancer cell (MDA-MB-231) invasion. Materials and Methods This study used a restoration-based approach by miR-31 mimic and optimized BRMS1 gene sequences, which were cloned into a chimeric construct and transfected to the MDA-M231cells. Results Our data revealed that the
TY - JOUR. T1 - Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy. AU - Noguchi, Kohji. AU - Katayama, Kazuhiro. AU - Mitsuhashi, Junko. AU - Sugimoto, Yoshikazu. N1 - Funding Information: We apologize that, due to space limitations, we could not cite the excellent work of many investigators. This work was supported by a grant-in-aid for Cancer Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.. PY - 2009/1/31. Y1 - 2009/1/31. N2 - The breast cancer resistance protein, BCRP/ABCG2, is a half-molecule ATP-binding cassette transporter that facilitates the efflux of various anticancer agents from the cell, including 7-ethyl-10-hydroxycamptothecin, topotecan and mitoxantrone. The expression of BCRP can thus confer a multidrug resistance phenotype in cancer cells, and its transporter activity is involved in the in vivo efficacy of chemotherapeutic agents. Thus, the elucidation of the substrate preferences and structural relationships ...
We have shown: (a) that adenoviral vector-mediated overexpression of the wild-type FHIT gene efficiently inhibited growth of tumor cells of varying FHIT gene and gene product status in vitro; (b) that the tumorigenicity of the Ad-FHIT-transduced tumor cells was eliminated in vivo; and (c) that tumor growth was significantly suppressed by direct injection of the FHIT-expressing adenoviral vector into s.c. tumors in nude mice. These results provided direct evidence for the biological function of FHIT as a tumor suppressor gene both in vitro and in vivo.. The lung cancer cell lines H1299, A549, and H460 and the head and neck carcinoma cell line 1483 all exhibit an altered or inactivated FHIT gene, as shown by reverse transcription-PCR and Northern blot analysis (7 , 9 , 18) , lack endogenous Fhit protein expression, as shown by Western blot analysis, and are highly tumorigenic. Alterations in the FHIT locus have been shown to be correlated with loss or reduction of Fhit protein expression in tumors ...
In this study, we have demonstrated that 44% of colorectal cancers have markedly reduced expression of Fhit protein. A similar reduction of Fhit protein expression has been reported in other human tumors such as lung (4) , cervical (12) , renal (11) , pancreatic (10) , head and neck (6) , and breast (5) carcinomas. The frequent loss of Fhit protein expression, the expression of aberrant FHIT transcripts, and numerous deletions within the FHIT gene suggest that FHIT is a candidate suppressor gene common to many cancers (reviewed in Ref. 1 ). In addition to the loss of Fhit protein expression, our studies found additional evidence that suggests that Fhit is important in colon tumorigenesis. A trend of increased proportions of colorectal cancers expressed reduced levels of Fhit (a) with decreasing degrees of differentiation, (b) with more advanced stages (Dukes stage C and D) compared with less advanced stages (Dukes stage A and B) of primary tumors, and (c) in metastatic lesions compared with ...
The tumour suppressor gene FHIT, encompassing the FRA3B fragile web page on chromosome 3p14. two, is a lot more than 1 Mb in size and encodes to get a one. 1 kb cDNA. It belongs for the histidine triad superfamily and encodes a cytoplasmic 16. eight kDa protein. Epithelial cells in many human tissues strongly express Fhit protein, though Fhit expression is absent or decreased inside a massive fraction of tumours. Fhit protein reduction or absence takes place in 70% of breast cancer specimens, suggesting that alter ation of Fhit expression on this tumour is really a regular occasion, brought on by each alterations while in the regulation of Fhit expression and from the very well documented biallelic deletion of the gene. To determine how Fhit down regulation influ ences breast cancer progression, we have examined protein expression at various phases with the sickness.. Commencing from usual epithelia, we now have also considered morphological lesions of various grades, such as atypical ductal ...
1FHI: Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.
Nightboat Books, 160 pp.. When I begin to think of a (any) body and its liminal (autocorrect wants to reaffirm it as luminal) itineraries in a world that aches to slap a miscellany of labels onto it, two different declarations splice my grasp of reality -. We have acceleration. We have trajectory. But above all, we have synthesis. (Ahmed Salman). I, the holding and the holding back. (Traci Brimhall, closing lines to Arctic Lullaby ). Is the parallax from synthesis to separation (and subtraction even, if we delve further into the act of holding back following the holding) merely another form of contour rivalry or an active, ungoverned metamorphosis?. Seattle-based poet Maged Zaher likes to send his poems swimming in this very fathomless arroyo, like the small, yet ancient pupfish of Death Valley, which I had the privilege and delight of saying hi to earlier this year. I also had the privilege and delight of spending time listening to Maged in his house, seated amidst books and plants, ...
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Extra resources for Chemistry and pharmacology of anticancer drugs. Example text. 3). Patrin is already being investigated in the clinic in combination with temozolomide (see Chapter 3 and Chapter 12). Similarly, there is much interest in developing drugs that can inhibit the action of MDR1 as a means to enhance the effectiveness of existing chemotherapeutic agents. There is also growing interest in developing inhibitors against the recently discovered breast cancer resistance protein (BCRP or ABCG2). This protein, an ABC transporter and marker of stem and progenitor cells, confers a strong survival advantage to breast cancer cells under hypoxic conditions. Totowa, NJ: Humana Press, 2003. J. ): Smith and Williams Introduction to the Principles of Drug Design and Action, 4th Edition, CRC Press, Boca Raton, FL, 411-522, 2005. J. Viruses and Human Cancer, Brit. Med. , 50:560-581, 1994. What You Need to Know About Cancer, Sci. Am. (Special Issue), 275:4-167, 1996. , ed. New Approaches in ...
The statements, opinions and data contained in the journal Biology are solely those of the individual authors and contributors and not of the publisher and the editor(s ...
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DB-ID: Database ID of variant, grouping multiple observations of the same variant together, starting with the HGNC gene symbol, followed by an underscore (_) and a six digit number (e.g. DMD_012345). _000000 is used for variants where DNA was not analysed (change predicted from RNA analysis), variants seen in animal models or variants not seen in humans but functionally tested in vitro ...
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Эндосиалин (CD248), называемый также TEM1 (от англ. tumor endothelial marker 1), экспрессирован на стромальных клетках растущих тканей на эмбриональной стадии. Во взрослом организме отсутствует, но может быть экспрессирован на опухолевых клетках и при воспалении. Играет роль в росте опухоли и воспалении, но механизм его влияния неизвестен.[1][2]. Экспрессирован на сосудистых эндотелиальных клетках злокачественных опухолей, но не на клетках нормальных сосудов.[3] ...
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ラット・モノクローナル抗体 ab24115 交差種: Ms,Hu 適用: WB,IHC-P,IHC-Fr,ICC,Flow Cyt,ICC/IF…BCRP/ABCG2抗体一覧…画像、プロトコール、文献などWeb上の情報が満載のアブカムの Antibody…
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Definition of fragile histidine triad. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Methionyl-tRNA synthetase (MetRS) belongs to the family of 20 enzymes essential for protein biosynthesis. It links covalently methionine with its cognate tRNA. Crystal structures solved for bacterial MetRSs have given a number of interesting insights into enzyme architecture and methionylation catalysis. A comparison of sequences of MetRSs belonging to all kingdoms of life, as well as numerous biochemical and genetic studies have revealed the presence of various additional domains appended to the catalytic core of synthetase. They are responsible for interactions with tRNA and proteins. Tertiary structure of C-terminal tRNA-binding appendices can be deduced from those determined for their homologues: tRNA binding protein 111 and endothelial monocyte-activating polypeptide II. Contacts between MetRS and other proteins could be mediated not only by noncatalytic peptides but also by structural elements present in the catalytic core, e.g. Arg-Gly-Asp (RGD) motifs. Additional activities involve MetRS ...
Breast Tumor Kinase (Brk/PTK6) has a relatively limited expression profile in normal tissue. Its expression is restricted to epithelial cells that are differentiating such as those in the epidermis, and Brk expression appears to be absent from proliferating cells in normal tissue. Also, there is now some evidence to suggest that Brk plays a functional role in the differentiation of the keratinocytes in the epidermis. We have, therefore, investigated the role that Brk/PTK6 plays in normal human primary keratinocytes by suppressing protein levels using RNA interference. We show that as primary human keratinocytes are induced to differentiate in vitro, Brk levels decrease. Decreasing Brk protein levels lead to an increase in the number of cells with a permeable plasma membrane, a decrease in epidermal growth factor receptor (EGFR) and a parallel increase in keratin 10 levels, but classical markers of apoptosis or terminal differentiation are not affected. We propose Brk, Keratin 10 and EGFR are ...
Background: Development of a multidrug resistance (MDR) phenotype to chemotherapy remains a major barrier in the treatment of cancer. Gankyrin (p28, p28GANK or PSMD10) is an oncoprotein overexpressed in different carcinoma cell lines. The aim of this study was to compare Gankyrin expression level in MDR cells (MCF-7/ADR and MCF-7/ MX) and non-MDR counterparts (MCF-7). Methods: Gankyrin, MDR1 (also known as ABCB1; the ATP-binding cassette sub-family B member 1) and ABCG2 (also known as BCRP; the human breast cancer resistance protein) mRNA levels were analyzed by real-time RT-PCR. Western blot analysis was used to detect the protein expression levels of Gankyrin. Results: The PCR results showed that the expression of Gankyrin was significantly lower in the ABCG2 overexpressing cell line MCF-7/MX than in non-resistanct MCF-7 cells. In contrast, there were no significant differences in mRNA expression of Gankyrin in the MDR1 overexpressing cell line MCF-7/ADR in comparison with MCF-7 cells. Similarly,
Differential Effects of Chrysin on Nitrofurantoin Pharmacokinetics Mediated by Intestinal Breast Cancer Resistance Protein in Rats and Mice
Human melanoma antigen (MAGE) genes have been shown to be expressed in both normal tissues and in various tumors and tumor related cells. Two types of MAGE genes have been characterized based on their expression: type-I members are silent in all normal tissues except for in the male germ line and placenta while type-II members are expressed ubiquitously in both tumor and normal cells (Figure 1). MAGE-C subfamily members are type-I genes expressed in various tumor types; their proteins are tumor-specific antigens that can be recognized by cytolytic T lymphocytes. MAGE-D subfamily members are type-II members they do not encode for those tumor-specific antigens seen in type-I MAGE and are also expressed ubiquitously in normal adult tissues. While MAGE genes could be targets for immunotherapy, information on the function and expression pattern of MAGE-C and MAGE D genes, however, remains incomplete. Analysis of the gene expression of type-I and type-II MAGE genes in various histological tumors may ...
Get this from a library! Analyse des tumorrelevanten proteins survivin : molekulare charakterisierung der dimerisierung. [Cecilia Vallet; Shirley Knauer] -- Cecilia Vallet untersucht, wie der Wechsel zwischen der monomeren und der dimeren Form des Proteins Survivin reguliert ist. Survivin ist in nahezu allen malignen Tumorerkrankungen überexprimiert und ...
Purified Recombinant Human ABCG2, GST-tagged from Creative Biomart. Recombinant Human ABCG2, GST-tagged can be used for research.
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目的 系统评价卵巢癌组织中 Survivin mRNA 表达与卵巢癌的相关性。 方法 计算机检索 PubMed、The Cochrane Library(2016 年 11 期)、CBM、CNKI、VIP 和 WanFang Data 数据库,搜集公开发表的所有关于 Survivin mRNA 表达与卵巢癌临床病理特征关系的病例-对照研究,检索时限均为从建库至 2016 年 11 月。由 2 位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用 RevMan 5.2 软件进行 Meta 分析。 结果 共纳入 10 个病例-对照研究。Meta 分析结果显示:Survivin mRNA 表达在卵巢癌组高于对照组[OR=24.63,95% CI(13.44,45.15),P|0.000 01],其在低分化组表达高于高分化组[OR=3.69,95% CI(2.29,5.93),P|0.000 01],在临床 Ⅲ~Ⅳ 期组表达高于临床 Ⅰ~Ⅱ 期组[OR=4.76,95% CI(2.99,7.57),P|0.000 01]。但其表达与有无淋巴结转移
目的 系统评价卵巢癌组织中 Survivin mRNA 表达与卵巢癌的相关性。 方法 计算机检索 PubMed、The Cochrane Library(2016 年 11 期)、CBM、CNKI、VIP 和 WanFang Data 数据库,搜集公开发表的所有关于 Survivin mRNA 表达与卵巢癌临床病理特征关系的病例-对照研究,检索时限均为从建库至 2016 年 11 月。由 2 位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用 RevMan 5.2 软件进行 Meta 分析。 结果 共纳入 10 个病例-对照研究。Meta 分析结果显示:Survivin mRNA 表达在卵巢癌组高于对照组[OR=24.63,95% CI(13.44,45.15),P|0.000 01],其在低分化组表达高于高分化组[OR=3.69,95% CI(2.29,5.93),P|0.000 01],在临床 Ⅲ~Ⅳ 期组表达高于临床 Ⅰ~Ⅱ 期组[OR=4.76,95% CI(2.99,7.57),P|0.000 01]。但其表达与有无淋巴结转移
Mouse monoclonal Stromal interaction molecule 1 antibody validated for WB, IP, IHC, ICC, Flow Cyt, ICC/IF and tested in Human. Referenced in 2 publications and…
TY - JOUR. T1 - Online fluorescent method to assess BCRP/ABCG2 activity in suspension cells. AU - Hooijberg, J H. AU - Peters, G J. AU - Kaspers, G J L. AU - Wielinga, P R. AU - Veerman, A J P. AU - Pieters, R. AU - Jansen, G. PY - 2004/10. Y1 - 2004/10. N2 - An online method was developed to monitor BCRP mediated efflux of fluorescent substrates in suspension cells. To this end, a 2-compartment system consisting of a transwell cup and a cuvette was used. In this system we were able to observe differences in efflux kinetics between BCRP overexpressing RPMI 8226/MR cells and parental myeloid RPMI 8226(s) cells using only 50,000 cells per experiment. 8226/MR cells displayed a larger cellular efflux rate of the BCRP substrate Hoechst 33342, as compared to the wildtype cells. This difference in efflux rate was completely decreased in the presence of the BCRP inhibitor Ko143.. AB - An online method was developed to monitor BCRP mediated efflux of fluorescent substrates in suspension cells. To this ...
The principle role of the company is to identify, to verify the validity and ultimately to offer a range of biochemical assays each of which will provide unique and informative results to the condition of an individual patient from which the physician can
The human MAGE genes are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. These genes encode tumor-specific antigens recognized by cytolytic T lymphocytes. The MAGE genes are located on …
Complete information for STIM2 gene (Protein Coding), Stromal Interaction Molecule 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
MAAAPGLLVW LLVLRLPWRV PGQLDPSTGR RFSEHKLCAD DECSMLMYRG EALEDFTGPD CRFVNFKKGD PVYVYYKLAR GWPEVWAGSV GRTFGYFPKD LIQVVHEYTK EELQVPTDET DFVCFDGGRD DFHNYNVEEL LGFLELYNSA ATDSEKAVEK TLQDMEKNPE LSKEREPEPE PVEANSEESD SVFSENTEDL QEQFTTQKHH SHANSQANHA QGEQASFESF EEMLQDKLKV PESENNKTSN SSQVSNEQDK IDAYKLLKKE MTLDLKTKFG STADALVSDD ETTRLVTSLE DDFDEELDTE YYAVGKEDEE NQEDFDELPL LTFTDGEDMK TPAKSGVEKY PTDKEQNSNE EDKVQLTVPP GIKNDDKNIL TTWGDTIFSI VTGGEETRDT MDLESSSSEE EKEDDDDALV PDSKQGKPQS ATDYSDPDNV DDGLFIVDIP KTNNDKEVNA EHHIKGKGRG VQESKRGLVQ DKTELEDENQ EGMTVHSSVH SNNLNSMPAA EKGKDTLKSA YDDTENDLKG AAIHISKGML HEEKPGEQIL EGGSESESAQ KAAGNQMNDR KIQQESLGSA PLMGDDHPNA SRDSVEGDAL VNGAKLHTLS VEHQREELKE ELVLKTQNQP RFSSPDEIDL PRELEDEVPI LGRNLPWQQE RDVAATASKQ MSEKIRLSEG EAKEDSLDEE FFHHKAMQGT EVGQTDQTDS TGGPAFLSKV EEDDYPSEEL LEDENAINAK RSKEKNPGNQ GRQFDVNLQV PDRAVLGTIH PDPEIEESKQ ETSMILDSEK TSETAAKGVN TGGREPNTMV EKERPLADKK AQRPFERSDF SDSIKIQTPE LGEVFQNKDS DYLKNDNPEE HLKTSGLAGE PEGELSKEDH ENTEKYMGTE SQGSAAAEPE DDSFHWTPHT ...
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Survivin expression becomes gradually restricted to β-cells after birth. A: Survivin expression in pancreatic endocrine and exocrine cells from E15.5 to P21, a
Predicted to have ATP binding activity and ATPase-coupled transmembrane transporter activity. Predicted to be involved in cholesterol efflux. Predicted to localize to plasma membrane. Orthologous to human ABCG4 (ATP binding cassette subfamily G member 4 ...
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
北海道大学電子科学研究所は、物理・化学・数学に基礎をおいた従来の学問体系から脱却し、生命科学の成果をも積極的に取り込んで新しい電子科学の領域を開拓することを目的としています。
The first human (mammalian) members of the MAGE (Melanoma-associated antigen) gene family that have been described are expressed in tumor cells but silent in
Each rotation list is more of a priority list--in real-time, youll constantly be determining which ability to use next. Arcane mages are getting an 8% overall buff next week in 8.2.5! Or sign in with one of these services. Fire Mage. Mage Arcane Mage Fire Mage Frost Mage. In this guide, we will detail the best stat priority for your Arcane Mage, as well as provide explanations covering how to determine Arcane Mage stat priorities personalized for your character in , as well as how to check if a piece of gear is BiS, upgrade or just bad for you. #Frost Mage DPS Rotation & Cooldowns. Mage pve dps gear/legendaries and Macro Icy Veins. Mage mage in TBC! Patch 9.0. MAGE: Talent Calculator - AoWoW - World of Warcraft Database Mage AOE Talent Spec ARCANE: Level 1 - Arcane Intellect Rank 1 , Level 2 Level 3 Level 4 - Conjure Water Rank 1 , Level 5 Level 6 - Conjure Food Rank 1 , Level 7 Level 8 - Arcane Missiles Rank 1 , Polymorph Rank 1 Level 9 Level 10 - Conjure Water Rank 2 Level 11 Level 12 - ...
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Desmoyokin (AHNAK) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species ...
TaeKwonDood tips us to news that a new cancer resistance treatment is going into clinical trials after being quite successful at eradicating cancer in mice. Researchers discovered that certain white blood cells called granulocytes from cancer-immune mice were able to cure cancer in other mice. Now, ...
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TTYH1 - TTYH1 (untagged)-ORIGENE UNIQUE VARIANT 1 of Human tweety homolog 1 (Drosophila) (TTYH1), available for purchase from OriGene - Your Gene Company.
An international team of researchers has discovered a new anti cancer protein which can help in the diagnosis of liver cancer. The protein is ...
View mouse Fermt1 Chr2:132904389-132945906 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
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Chen S, Maul RS, Kim HR, Chang DD (Jul 2000). "Characterization of the human EPLIN (Epithelial Protein Lost in Neoplasm) gene ... Maul RS, Chang DD (Feb 2000). "EPLIN, epithelial protein lost in neoplasm". Oncogene. 18 (54): 7838-41. doi:10.1038/sj.onc. ... LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene. EPLIN is a cytoskeleton- ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ...
Steroid Receptor Associated and Regulated Protein (SRARP) in humans is a protein encoded by a gene of the same name with two ... September 1999). "DNA copy number losses in human neoplasms". The American Journal of Pathology. 155 (3): 683-94. doi:10.1016/ ... "Steroid receptor-associated and regulated protein". UniProt. Retrieved 2 May 2020. Su D, Fu X, Fan S, Wu X, Wang XX, Fu L, et ... Another similar molecular feature between SRARP and HSPB7 is the fact that both of these proteins interact with the 14-3-3 ...
Eye cancer Eye examination Retinoblastoma protein American Cancer Society (2003). "Chapter 85. Neoplasms of the Eye". Cancer ... In other cases, it is caused by a congenital mutation in the chromosome 13 gene 13q14 (retinoblastoma protein). Retinoblastoma ... Although RB1 interacts with over 100 cell proteins, its negative regulator effect on the cell cycle principally arises from ... Roarty JD, McLean IW, Zimmerman LE (November 1988). "Incidence of second neoplasms in patients with bilateral retinoblastoma". ...
... matrix protein (M), fusion protein (F), neuraminidase (NA) and large protein (L). All these proteins have variable functions ... Its expression is also increased in a wide range of other malignant neoplasms. Factor X (F10) is frequently expressed in normal ... F-protein, as other paramyxoviral fusion proteins, is a trimeric class I viral membrane fusion protein. It is produced in the ... "ASGR1 protein expression summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2020-01-14. "ASGR2 protein ...
The mammalian TET proteins were found to be orthologues of Trypanosoma brucei base J-binding protein 1 (JBP1) and JBP2. Base J ... Mutations in this gene were first identified in myeloid neoplasms with deletion or uniparental disomy at 4q24. TET2 may also be ... An explanation for protein function was provided in 2009 via computational search for enzymes that could modify 5mC. At this ... TET2 encodes a protein that catalyzes the conversion of the modified DNA base methylcytosine to 5-hydroxymethylcytosine. The ...
2013). "Screening for Muir-Torre syndrome using mismatch repair protein immunohisochemistry of sebaceous neoplasms". J Genet ... Along with neoplasms of the sebaceous gland, this patient developed cerebral neoplasms, characteristic of Turcot syndrome. ... Colorectal cancer is the most common visceral neoplasm in Muir-Torre syndrome patients. It is named for EG Muir and Douglas ... Age of onset of first sebaceous neoplasm: 2 = 2 points. Personal history of Lynch related cancers: No = 0 points, Yes = 1 point ...
2006). "Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms". Cancer Biol. Ther ... Hedgehog interacting protein (HHIP) is a protein that in humans is encoded by the HHIP gene. This gene encodes a protein ... 2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and ... 2004). "Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in ...
2007). "Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms". Haematologica. 92 (2): 176- ... This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH ... Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene. ... "Entrez Gene: IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2". Yisraeli JK (2005). "VICKZ proteins: a multi- ...
... proteins, and fats in food entering the duodenum from the stomach. Papillary - In oncology, papillary refers to neoplasms with ... Antibody - (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is ... Fingernails and toenails are made of a tough protective protein called alpha-keratin which is found in the hooves, hair, claws ... Cytokines - are a broad and loose category of small proteins (~5-20 kDa) that are important in cell signaling. Cytokines are ...
"Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms". Thyroid. 15 (10): 1131-6 ... acetylation of ribosomal protein S18". Protein Science. 17 (10): 1781-90. doi:10.1110/ps.035899.108. PMC 2548364. PMID 18596200 ... "N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...
"Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms". Thyroid. 15 (10): 1131-6 ... The crystal structure of human NatA bound to the protein HYPK has also been solved. Because TPR motifs mediate protein-protein ... NatA may also regulate co-translational protein folding and protein targeting to the endoplasmic reticulum, possibly through ... NMDA receptor-regulated protein 1 (NARG1), and Tbdn100 is a protein that in humans is encoded by the NAA15 gene. NARG1 is the ...
This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. NUP88 has been shown ... "Developing chick embryos express a protein which shares homology with the nuclear pore complex protein Nup88 present in human ... The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 ... Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene. The nuclear pore complex is a massive ...
The coding region is 2086 base pairs, and the protein sequence contains 615 amino acids. The protein encoded by c2orf81 is ... Disease states in which it is expressed include in gliomas, neoplasm, and lymphoma. Only a few mutations have been documented ... The N-terminus of the protein has evolved less quickly than the rest of the protein. "Chromosome 2: 74,414,176-74,421,591 - ... The c2orf81 protein is conserved highly in primates and other mammals, but less so in non-mammalian vertebrates. Its most ...
PaSCs express the intermediate filament proteins desmin and glial fibrillary acidic protein. The expression of a diverse range ... distinguished by an increase in the connective tissue that surrounds the neoplasm. Activated PaSCs in the tumour desmoplasia of ... Protein kinases such as MAPKs are primary mediators of activating signals initiated by the growth factors, angiotensin II and ... The up regulation of matri-cellular proteins such as galectin-1, and tenascin-C is present in the stromal tissues of pancreatic ...
This V617F mutation render's the protein's tyrosine kinase continuously active and results in a myeloproliferative neoplasm ... The FLT3 gene codes for the cluster of differentiation antigen 135 (i.e. CD135) protein or FLT3 protein. This protein is a ... The ACSL6 gene encodes a protein, CSL6 acyl-CoA synthetase long-chain family member 6 (or ACSL6 protein). This protein is a ... BCR encodes the breakpoint cluster region protein. This protein possess Serine/threonine-specific protein kinase activity and ...
The protein was identified during investigations on the origin of multiple myeloma, a B-cell hematologic neoplasm. To ... The discovery of Protein M, a new protein from M. genitalium, was announced in February 2014. ... The protein is about 50 kDa in size, and composed of 556 amino acids. Tully, J. G.; Taylor-Robinson, D.; Rose, D. L.; Cole, R. ... The antibody reactivity was due to a protein never known before, and is chemically responsive to all types of human and ...
The same article also pointed out that MYB-QKI protein facilitates the growth of vessels around the glioma. AG often behaves as ... Brat DJ, Scheithauer BW, Fuller GN, Tihan T (July 2007). "Newly codified glial neoplasms of the 2007 WHO Classification of ... Yet, a series of suspected causes are under discussion, including the possible MYB-QKI protein fusion theory on AG etiology. ... The research group proved that this protein alternation could be the critical contributor to AG oncogenicity since mice showed ...
Pathologists discovered a BCL-2 protein, commonly present in neoplasms, to exist in the tissue layers of the GOC. The protein ... The analysis of PTCH, a gene that specialises in neoplasm inhibition, was carried out to determine if any existing mutations ... a popular type of neoplasm at the salivary glands. GOC is usually misdiagnosed with other lesions developed at the glandular ...
Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene. Mutations in ... in pulmonary neuroendocrine cells and neoplasms". Pathol. Int. 46 (6): 393-8. doi:10.1111/j.1440-1827.1996.tb03629.x. PMID ... Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and ... Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and ...
The molecular mass of the mature, glycosylated PDGFRα protein is approximately 170 kDA. cell surface tyrosine kinase receptor ... myeloproliferative neoplasm/myeloblastic leukemia; a T-lymphoblastic leukemia/lymphoma; or myeloid sarcoma; b) are diagnosed ... The fused gene encodes a FIP1L1-PDGFRA protein that causes: a) chronic eosinophilia which progresses to chronic eosinophilic ... These mutations create fused genes which encode chimeric proteins that possess continuously active PDGFRA-derived tyrosine ...
The MPL gene codes for a protein that acts as a receptor for thrombopoietin. A mutation in that gene, known as a W515 mutation ... It is classified by the World Health Organization (WHO) as a type of myeloproliferative neoplasm, a group of cancers in which ... The V617F mutation to the JAK2 protein is found in approximately half of individuals with primary myelofibrosis. The V617F ... In 2016, the WHO revised their classification of myeloproliferative neoplasms to define Prefibrotic primary myelofibrosis as a ...
... is commonly found in precancerous dysplasias and malignant neoplasms. Nucleoporin protein aladin is a component of the nuclear ... The proteins lining the inner pore make up the NUP62 complex. On the nucleoplasm side, extra proteins associated with the ring ... Different sets of proteins associate on either ring, and some transmembrane proteins anchor the assembly to the lipid bilayer. ... Karyopherins can serve as an importin (transporting proteins into the nucleus) or an exportin (transporting proteins out of the ...
Cancer alters the DNA of cells and the mutated genetic material is passed on to daughter cells, resulting in neoplasms. The ... The Oncept vaccine activates T-cell responses and antibodies against tumor-specific tyrosinase proteins. There is limited ... Carcinogenesis is linked with DNA mutations, chromosomal translocations, dysfunctional proteins, and aberrant cell cycle ...
... a marker protein for neuroendocrine cells and neoplasms". Proceedings of the National Academy of Sciences of the United States ... The encoded protein has 313 amino acids with a predicted molecular weight of 33.845 kDa. The protein is a synaptic vesicle ... Synaptophysin, also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene. ... The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when ...
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as ... or monoclonal antibody termed Ki-67 can be used for grading of different neoplasms, e.g. astrocytoma. They can be of diagnostic ... Proteins binding to PCNA via the PIP-box are mainly involved in DNA replication whereas proteins binding to PCNA via APIM are ... binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. ...
One small series of 6 cases showed that MDM2 protein was expressed in 5 of them (83%), and p53 protein was overexpressed in 50 ... Although it is not normally considered a fast-growing malignant neoplasm, FA can exhibit high uptake on FDG-PET scanning. ... Identification of aberrant nuclear localization of a mutated protein product of the beta-catenin gene has been proposed as a ...
... is a protein that in humans is encoded by the AKNA gene. The protein is an AT-hook transcription factor which contains an ... It is not uncommon for this chromosome to play a role in neoplasm and inflammatory diseases because how frequently it undergoes ... "AKNA - Microtubule organization protein AKNA - Homo sapiens (Human) - AKNA gene & protein". www.uniprot.org. Retrieved 2020-05- ... "AKNA protein expression summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2020-05-01. "AKNA Gene - GeneCards ...
These neoplasms also accounted for 73% of the multiple primary cancers occurring in 15 family members. Six of these patients ... P53 The p53 tumor suppressor protein. National Center for Biotechnology Information (US). 1998. Wikiquote has quotations ... and other neoplasms in young patients. Cancer developed in an autosomal dominant pattern in 151 blood relatives, 119 (79%) of ... and other neoplasms". Science. 250 (4985): 1233-8. Bibcode:1990Sci...250.1233M. doi:10.1126/science.1978757. PMID 1978757. ...
... in the serum protein electrophoresis because there will be an excess of production of one protein. There are two large classes ... It is usually due to an underlying immunoproliferative disorder or hematologic neoplasms, especially multiple myeloma. It is ... AL amyloidosis These are characterized by the presence of any abnormal protein that is involved in the immune system, which are ... The β band consists of transferrin, low-density lipoproteins, and complement system proteins. The γ band is where the ...
Zinc finger protein 238 (also known as RP58 or ZBTB18) is a zinc finger containing transcription factor that in humans is ... resulting in a cellularly diverse neoplasm. This new diversity has been observed to increase the invasiveness of the tumor, ... ZNF238+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... C2H2-type zinc finger proteins, such as ZNF238, act on the molecular level as transcriptional activators or repressors and are ...
Male Genitals - Prostate Neoplasms»։ Pathology study images։ University of Virginia School of Medicine։ Արխիվացված է օրիգինալից ... Expression of X-linked inhibitor of apoptosis protein in human prostate cancer specimens with and without neo-adjuvant hormonal ...
Within this protein-coding DNA (called the exome), an average cancer of the breast or colon can have about 60 to 70 protein ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... p. Neoplasm. ISBN 978-0781733908. .. *^ "II Neoplasms". International Statistical Classification of Diseases and Related Health ... The term neoplasm is a synonym of tumor. Neoplasia denotes the process of the formation of neoplasms/tumors, and the process is ...
Neoplasm. பன்னாட்டுத் தரப்புத்தக எண்:978-0781733908. *↑ "Causes and risk factors". Macmillan Cancer Support. 13 பெப்ரவரி 2019 ... Retinoblastoma protein) அல்லது புற்று நோய் வரமால் அடக்கி வைக்கும் மரபணுக்களில் (en:Tumor suppressor (எ.கா.en:p53) ஏற்படும் ... புத்திழையப் பெருக்கம் (Neoplasm): சூழவுள்ள இழையத்திலிருந்து வேறுபட்டு, குறிப்பிட்ட ஒரு இழையத்தில், புதிதாக நிகழும் ஒரு அசாதாரண ... Neoplasm) ஒரு பிரிவாகும். எல்லாப் புற்றுநோய்க் கட்டிகளிலும் ஆறு முக்கியமான இயல்புகள் (en:The Hallmarks of Cancer)
Rindi G, Klimstra DS, Abedi-Ardekani B, Asa SL, et al «A common classification framework for neuroendocrine neoplasms: an ... UniProt «Transthyretin» (en anglès). Protein knowledgebase. UniProt Consortium, 2019 Gen 16; P02766 (TTHY_HUMAN) (rev), pàgs: ... Masroor FA, Gilde J, Liang J «Vidian Nerve Schwannoma: A Rare Skull-Base Neoplasm Presenting with Ocular Manifestations: A Case ... Macarenco, RS; Ellinger, F; Oliveira, AM «Perineurioma: A Distinctive and Underrecognized Peripheral Nerve Sheath Neoplasm» (en ...
Neoplasms of the Eye". Cancer Medicine. Hamilton, Ontario: BC Decker Inc. ISBN 978-1-55009-213-4. .. ... U drugim slučajevima je uzrokovana urođenom mutacijom u hromosomu 13, genu na lokusu13q14 (retinoblastomski protein).[2] ... "Incidence of second neoplasms in patients with bilateral retinoblastoma". Ophthalmology. 95 (11): 1583-1587. doi:10.1016/s0161 ...
Hanash SM (September 2000). "Operomics: molecular analysis of tissues from DNA to RNA to protein". Clin. Chem. Lab. Med. 38 (9 ... caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm ... Two such classes are the kinase family, involved in adding phosphate groups to proteins and the phosphatase family, involved ... The mutations disregulated mTOR, the protein inhibited by everolimus, allowing it to reproduce without limit. As a result, in ...
Within this protein-coding DNA (called the exome), an average cancer of the breast or colon can have about 60 to 70 protein ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... p. Neoplasm. ISBN 978-0781733908. .. *^ "II Neoplasms". International Statistical Classification of Diseases and Related Health ... The term neoplasm is a synonym of tumor. Neoplasia denotes the process of the formation of neoplasms/tumors, and the process is ...
Naziv leukemijski virus nosi sličan protein. Simbol BCR je izveden iz regiona klastera tačke prekida, gena koji kodira protein ... "Myeloproliferative Neoplasms" (PDF). NCCN Clinical Practice Guidelines. National Cancer Comprehensive Network. 15 November 2021 ... Ovaj gen je ABL1 na hromosomu 9 klasterske regije tačke prekida gena BCR sa hromosoma 22, kodirajući za hibridni protein: ... Prerađeni protein BCR-ABL1 stupa u interakciju sa beta(c) podjedinicom receptora interleukina-3 i moderira aktivacijsku petlju ...
"The stomach cancer proteome - The Human Protein Atlas". www.proteinatlas.org.. *^ Uhlen M, Zhang C, Lee S, Sjöstedt E, ... "Volatile organic compounds as a potential screening tool for neoplasm of the digestive system: a meta-analysis". Scientific ... "Gastric Cancer Pre-Stage Detection and Early Diagnosis of Gastritis Using Serum Protein Signatures". Molecules. 27 (9): 2857. ...
ASCL1 protein encoded by the ASCL1 gene, Dok-7 protein encoded by the DOK7 gene, enolase 2 encoded by the ENOL2 gene, ... The World Health Organization (2019) classified papillary neoplasms (i.e. benign or cancerous tumors) of the breast into 5 ... and the expression of neuroendocrine differentiation-related proteins such as the GDNF family of ligand proteins encoded by the ... Brogi E, Krystel-Whittemore M (January 2021). "Papillary neoplasms of the breast including upgrade rates and management of ...
These cells have proteins that make up the characteristics of the tumor. These proteins arise from blood vessels, nerve cells ... The critical diagnosis of this neoplasm is often difficult because of its similarity with other primary or secondary papillary ... The cytoplasmic and often nuclear expression of S100 protein is present in nearly all tumor cells, and vimentin typically ... neurofilament protein) → - CD56/N-CAM (neural cell adhesion molecule) → ++ S100 → ++ Transthyretin → - Vimentin → +++ Desmin ...
TTC39A has been tested for association to diseases like breast neoplasms and is expected to have molecular binding function and ... Tetratricopeptide repeat protein 39B is a protein that in humans is encoded by the TTC39B gene. TTC39B is also known as C9orf52 ... "Tetratricopeptide repeat protein 39B isoform 1 [Homo sapiens] - Protein - NCBI". "NCBI". Retrieved 9 May 2013.[permanent dead ... This article focuses on tetratricopeptide repeat protein 39B isoform 1, the longest of all of the proteins. When translated, ...
... protein defect of Cystinosis Cystinuria Cystinuria-lysinuria Cytochrome C oxidase deficiency Cytomegalic inclusion disease ... Carrington syndrome Cartilage hair hypoplasia like syndrome Cartilage-hair hypoplasia Cartilaginous neoplasms Cartwright-Nelson ... hypoxia Cerebral malformations hypertrichosis claw hands Cerebral palsy Cerebral thrombosis Cerebral ventricle neoplasms ... Choriocarcinoma Chorioretinitis Chorioretinopathy dominant form microcephaly Choroid plexus cyst Choroid plexus neoplasms ...
... protein that promotes cell growth and proliferation. Inactivation of one of the TSC1 or TSC2 genes appears responsible for ... Connective and soft tissue neoplasms, Benign neoplasms). ...
"Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The ... which is a myelodysplastic syndrome/myeloproliferative neoplasm). There is also an emerging body of evidence to suggest ... "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The ... "Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155". Molecular and Cellular ...
... cutaneous neoplasms associated with systemic syndromes List of cutaneous conditions caused by problems with junctional proteins ...
Blood tests show the level of IgM in the blood and the presence of proteins, or tumor markers, that are the key signs of ... ISBN 978-0-7817-5007-3. Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and ... Serum protein electrophoresis results indicate evidence of a monoclonal spike but cannot establish the spike as IgM. An M ... This is attributed to the IgM monoclonal protein increasing the viscosity of the blood by forming aggregates to each other, ...
Comparison of Neoplasms in Six Sources of Rats Diamond JM (January 2006). Collapse: How Societies Choose to Fail or Succeed. ... This results in the lowered expression of reelin protein, essential for proper cortex lamination and cerebellum development. ... The Lewis rat suffers from several spontaneous pathologies: first, they can suffer from high incidences of neoplasms, with the ... A 1972 study compared neoplasms in Sprague Dawley rats from six different commercial suppliers and found highly significant ...
Otherwise, CDK4/6 binds cyclin D and forms an active protein complex that phosphorylates retinoblastoma protein (pRB). Once ... However, p16 can be expressed in other neoplasms and in several normal human tissues. More than a third of urinary bladder SCCs ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi: ... a type 1 protein-phosphatase-binding protein". The Journal of Biological Chemistry. 276 (17): 14161-9. doi:10.1074/jbc. ...
The encoded protein is a type 1A regulatory subunit of protein kinase A. Inactivating germline mutations of this gene are found ... Melanocytic nevi and neoplasms, Syndromes affecting the skin, Syndromes affecting the heart, Syndromes with tumors). ... transition in the second codon position of the 74th codon in the protein) mutation in the PRKAR1A gene, confirming a diagnosis ... "Pancreatic ductal and acinar cell neoplasms in Carney complex: a possible new association". J Clin Endocrinol Metab. 96 (11): ...
Transport protein ZIP1 is responsible for the transport of zinc into prostate cells. One of zinc's important roles is to change ... "Male Genitals - Prostate Neoplasms". Pathology study images. University of Virginia School of Medicine. Archived from the ... Ford OH, Gregory CW, Kim D, Smitherman AB, Mohler JL (November 2003). "Androgen receptor gene amplification and protein ... Loss of the retinoblastoma (RB) protein induces androgen receptor deregulation in castration-resistant prostate cancer by ...
Upregulation of the DNA repair protein EYA3 in this tumour is mediated by the fusion protein transcription factor EWS/FLI1, ... "miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets ... It directly downregulates the transmembrane protein 88 (TMEM88), a negative regulator of the Wnt signalling pathway. MicroRNA ...
... neoplasm protein - Nernst equation - nerve - nerve growth factor - nerve growth factor receptor - nerve tissue protein - nerve ... protein - protein biosynthesis - Protein Data Bank - protein design - protein expression - protein folding - protein isoform - ... protein P16 - protein P34cdc2 - protein precursor - protein structure prediction - protein subunit - protein synthesis - ... proto-oncogene protein C-kit - proto-oncogene proteins c-abl - proto-oncogene proteins c-bcl-2 - Proto-oncogene proteins c-fos ...
It encodes the protein neuronatin, a proteolipid, that functions in the control of ion channels during brain development. ... The loss of methylation within these areas triggers an irregular cell growth, resulting in embryonic neoplasms. Numata, Shusuke ... Increased expression in pancreatic islet beta cells causes the beta form of the protein to build an aggregate structure. This ... Neuronatin (Nnat) is a protein coding gene involved in mammalian brain development. It is located on Chromosome 20 in humans ...
December 2004). "Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odontogenic ... usually suprasellar neoplasm, which may be cystic, that develops from nests of epithelium derived from Rathke's pouch. Rathke's ...
K1 protein which promotes the malignancy of host cells; 7) G-protein coupled receptor protein which promotes host cells' ... This lymphoma also belongs to a group of lymphoid neoplasms with plasmablastic differentiation that involve malignant ... As detected by immunostaining methods, the malignant cells typically express molecular marker proteins such as CD45 (which is ... Potentially important examples include: 1) overexpression of the APOBEC3B gene whose protein product (termed "probable DNA dC-> ...
It can be recognized by a constant expression of the tumour receptor necrosis factor CD30, a membrane protein expressed by ... "The 2016 revision of the World Health Organization classification of lymphoid neoplasms". Blood. 127 (20): 2375-2390. doi: ... HTLV-1 encodes viral proteins to facilitate the proliferation of HTLV-1 infected cells. In the latent period, accumulation of ... It has a chimeric monoclonal antibody (cAC10) that binds to the membrane protein CD30. This binding delivers monomethyl ...
An example of this includes the interaction of the membrane proteins of the B7 family of the dendritic cell with CD28 present ... Blastic plasmacytoid dendritic cell neoplasm is a rare type of myeloid cancer in which malignant pDCs infiltrate the skin, bone ... Wang S, Wang X, Liu M, Bai O (April 2018). "Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel ... This communication can take the form of direct cell-cell contact based on the interaction of cell-surface proteins. ...
Protein Disulfide Isomerase Is Associated with Increased Risk of Thrombosis in JAK2-Mutated Myeloproliferative Neoplasms Anish ... Protein disulfide isomerase (PDI), an endoplasmic reticulum protein vital for protein folding, also possesses essential ... Protein disulfide isomerase (PDI), an endoplasmic reticulum protein critical for protein folding and chaperoning functions, ... Protein disulfide isomerase (PDI) plays a regulatory role in thrombosis and its inhibitors have been shown to prevent TEs in ...
BRAF/KRAS gene sequencing of sebaceous neoplasms after mismatch repair protein analysis. Hum Pathol. 2014 Jun; 45(6):1213-20. ... BRAF/KRAS gene sequencing of sebaceous neoplasms after mismatch repair protein analysis. ... BRAF/KRAS gene sequencing of sebaceous neoplasms after mismatch repair protein analysis. ...
Expression and prognostic significance of 14-3-3σ and ERM family protein expression in periampullary neoplasms. Cancer Biology ... Expression and prognostic significance of 14-3-3σ and ERM family protein expression in periampullary neoplasms. In: Cancer ... Expression and prognostic significance of 14-3-3σ and ERM family protein expression in periampullary neoplasms. / Hustinx, ... title = "Expression and prognostic significance of 14-3-3σ and ERM family protein expression in periampullary neoplasms", ...
Neoplasms. Hemostatic Disorders. Vascular Diseases. Cardiovascular Diseases. Paraproteinemias. Blood Protein Disorders. ... Neoplasms, Plasma Cell. Smoldering Multiple Myeloma. Neoplasms by Histologic Type. ... defined as serum M-protein ≥30 g/L or urinary M-protein ≥500 mg per 24 hour or both, and/or clonal bone marrow plasma cells ( ...
Neoplasms, Glandular and Epithelial / diagnosis* * Neoplasms, Glandular and Epithelial / metabolism * Ovarian Neoplasms / ... Does risk for ovarian malignancy algorithm excel human epididymis protein 4 and CA125 in predicting epithelial ovarian cancer: ... Backgrounds: Risk for Ovarian Malignancy Algorithm (ROMA) and Human epididymis protein 4 (HE4) appear to be promising ...
This lab test measures the types of protein in the fluid (serum) part of a blood sample. This fluid is called serum. ... Munshi NC, Jagannath S. Plasma cell neoplasms. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles ... Abnormal loss of protein from the digestive tract or the inability of the digestive tract to absorb proteins (protein-losing ... Proteins are made from amino acids and are important parts of all cells and tissues. There are many different kinds of proteins ...
G-protein-coupled receptor 5 expression and clinicopathological features of colorectal neuroendocrine neoplasms」の研究トピックを掘り下げます。 ... G-protein-coupled receptor 5 expression and clinicopathological features of colorectal neuroendocrine neoplasms. In: Pathology ... G-protein-coupled receptor 5 expression and clinicopathological features of colorectal neuroendocrine neoplasms. Pathology ... G-protein-coupled receptor 5 expression and clinicopathological features of colorectal neuroendocrine neoplasms, Pathology ...
Peritoneal Neoplasms / secondary* * Retrospective Studies * Treatment Outcome Substances * CEACAM5 protein, human * ... Celecoxib and Myrtol: A Novel Therapy for Recurrent Appendiceal Mucinous Neoplasms With Extensive Peritoneal Dissemination Am J ... Background: Unresectable appendiceal mucinous neoplasms (AMNs) with extensive peritoneal dissemination cause significant ...
Humans; Cancer; Brain-tumors; Tumors; Malignancy; Malignant-neoplasms; Mutation; Genes; Gene-mutation; Genetic-factors; Risk- ... factors; Nucleotides; Proteins; Ribonucleic-acids; Biomarkers; Heredity; Families; Morphology; Cell-morphology; Adenocarcinomas ...
Maxillary Neoplasms. EN. dc.subject.mesh. Ameloblastoma. EN. dc.title. Immunohistochemical detection of p53 protein in ... Overexpression of p53 protein could be a valid screening method for predicting underlying malignant genetic changes in AB types ... Immunohistochemical detection of p53 protein in ameloblastoma types. dc.contributor.author. El Sissy, N.A.. ... Overexpression of p53 protein in unicystic ameloblastoma [‎uAB]‎ is denser than in the conventional ameloblastoma [‎cAB]‎ type ...
... and squamous cell neoplasm. Orthologous to human STRAP (serine/threonine kinase receptor associated protein). [provided by ... General protein information Go to the top of the page Help Preferred Names. serine-threonine kinase receptor-associated protein ... mRNA and Protein(s) * NM_011499.3 → NP_035629.2 serine-threonine kinase receptor-associated protein ... protein coding. RefSeq status. VALIDATED. Organism. Mus musculus Lineage. Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; ...
Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms. / Liu, Yulin; Saad, Reda S.; Shen, ... Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms. In: Advances in Anatomic Pathology. ... Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms. Advances in Anatomic Pathology. 2003 ... Dive into the research topics of Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms. ...
protein coding gene. Chr11:87649022-87676754 (+). 129S1/SvImJ MGP_129S1SvImJ_G0018911. protein coding gene. Chr11:89392775- ... protein coding gene. Chr11:88515809-88546266 (+). BALB/cJ MGP_BALBcJ_G0018851. protein coding gene. Chr11:86347937-86373306 (+) ... protein coding gene. Chr11:88758439-88783785 (+). PWK/PhJ MGP_PWKPhJ_G0017990. protein coding gene. Chr11:86349703-86375156 (+) ... protein coding gene. Chr11:88317535-88342841 (+). WSB/EiJ MGP_WSBEiJ_G0018271. protein coding gene. Chr11:88649491-88676505 (+) ...
In vivo studies; Laboratory animals; Asbestos fibers; Inhalation studies; Long term study; Lung tissue; Lung fibrosis; Proteins ... Malignant neoplasms. CAS No.. 1332-21-4; 12001-29-5; 12001-29-5; 14567-73-8; 77536-66-4 ...
Neoplasms. Neuroendocrine Tumors. Neuroectodermal Tumors. Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. ... Protein Binding PD-1 and CTLA-4 in Patients With Unresectable or Metastatic Neoplasms. ... MGD019 DART® Protein in Unresectable/Metastatic Cancer. The safety and scientific validity of this study is the responsibility ...
Dive into the research topics of Localization and function of bam protein require the benign gonial cell neoplasm gene product ... Localization and function of bam protein require the benign gonial cell neoplasm gene product. ...
Neoplasm Neoplasm, Neoplastic; Neuroblastoma, Nuclear Oligonucleotide Oncogene Polymerase Preschool; Profiling; Prognosis; ... Proteins, RNA, Rate; Reaction; Regulation, Reverse Risk Sequence Staging; Studies; Survival Time Transcriptase Tumor genetics/ ... Neoplasm Neoplasm, Neoplastic; Neuroblastoma, Nuclear Oligonucleotide Oncogene Polymerase Preschool; Profiling; Prognosis; ... Proteins, RNA, Rate; Reaction; Regulation, Reverse Risk Sequence Staging; Studies; Survival Time Transcriptase Tumor genetics/ ...
108010011376 AMP-Activated Protein Kinases Proteins 0.000 description 70 * 206010028980 Neoplasm Diseases 0.000 description 39 ... 108020001507 fusion proteins Proteins 0.000 claims description 3 * 102000037240 fusion proteins Human genes 0.000 claims ... 102000004169 proteins and genes Human genes 0.000 description 32 * 108090000623 proteins and genes Proteins 0.000 description ... 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 description 7 * 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 ...
Leukemia, myelogenous, chronic, BCR-ABL positive; Drug resistance; Drug monitoring, neoplasm; Receptor Protein-Tyrosine Kinases ... Keywords: Leukemia, myelogenous, chronic, BCR-ABL positive/drug therapy; Drug resistance; Drug monitoring, neoplasm; Receptor ... This gene fusion codes for a chimeric protein, BCR-ABL, which is associated with the uncontrolled activity of ABL tyrosine ... Protein-Tyrosine Kinases; Pyrimidines/therapeutic use; Antineoplastic agents/administration & dosage; Monitoring; Prognosis ...
Keywords: Clinical Trials, Phase I as Topic; Medical Oncology; IL15 protein, human; Interleukin-15; Receptors, Interleukin-15; ... CD8-Positive T-Lymphocytes; Melanoma; Neoplasms; Signal Transduction; Killer Cells, Natural; pembrolizumab ...
Mandibular Neoplasms. 1. 2015. 132. 0.030. Why? cdc42 GTP-Binding Protein. 1. 2015. 198. 0.030. Why? ... Receptor-Like Protein Tyrosine Phosphatases, Class 3. 1. 2015. 31. 0.140. Why? ...
... are also enriched in a subset of genes whose expression correlates with HAX1 expression in four analyzed neoplasms. The ... HAX1 is a human protein with no known homologues or structural domains. Mutations in the HAX1 gene cause severe congenital ... SONAR discovers RNA-Binding proteins from analysis of large-scale protein-protein interactomes. Mol. Cell 2016, 64, 282-293. [ ... HAX1 (HCLS1-associated protein X-1) is known as an antiapoptotic protein with a role in the regulation of cell migration, cell ...
The secondary protein structures of most soluble precursor proteins (except for SAA and chromosomal prion protein [Prpc]) have ... and occasionally with neoplasms; it was formerly termed secondary amyloidosis.. Worldwide, AA is the most common systemic ... The precursor protein is the normal- or mutant-sequence transport protein transthyretin (TTR), a transport protein synthesized ... The amyloid beta precursor protein (AβPP), which is a transmembrane glycoprotein, is the precursor protein in beta protein ...
... power of estimates of vCJD prevalence might be increased by expanding screening to include samples of lymphoreticular neoplasms ... Hilton DA, Ghani AC, Conyers L, Edwards P, McCardle L, Penney M, Accumulation of prion protein in tonsil and appendix: review ... Hilton DA, Sutak J, Smith ME, Penney M, Conyers L, Edwards P, Specificity of lymphoreticular accumulation of prion protein for ... Hilton DA, Ghani AC, Conyers L, Edwards P, McCardle L, Ritchie D, Prevalence of lymphoreticular prion protein accumulation in ...
Picornaviridae; RNA; genes; immunity; interferons; mutation; neoplasm cells; proteins; viruses. Abstract:. ... Induction of ... Lates calcarifer; Redspotted grouper nervous necrosis virus; cages; cell lines; coat proteins; cytopathogenicity; ... bacterial communities; biofilm; biomarkers; colorectal neoplasms; digestive system diseases; digestive tract mucosa; human ... by the acquisition by horizontal gene transfer of a gene that encodes the β-lactam-insensitive penicillin-binding protein PBP2a ...
Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) tumors derived from choroid plexus ... whereas staining for S100 protein, glial fibrillary acidic protein (GFAP), transthyretin, and synaptophysin is more variable ( ... encoded search term (Pathology of Choroid Plexus Neoplasms) and Pathology of Choroid Plexus Neoplasms What to Read Next on ... Pathology of Choroid Plexus Neoplasms. Updated: Jan 10, 2018 * Author: Christine Fuller, MD; Chief Editor: Adekunle M Adesina, ...
Within this protein-coding DNA (called the exome), an average cancer of the breast or colon can have about 60 to 70 protein ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... p. Neoplasm. ISBN 978-0781733908. .. *^ "II Neoplasms". International Statistical Classification of Diseases and Related Health ... The term neoplasm is a synonym of tumor. Neoplasia denotes the process of the formation of neoplasms/tumors, and the process is ...
Neoplasm Metastasis; Niacinamide; Outcome Assessment, Health Care; Phenylurea Compounds; prognosis; Protein Kinase Inhibitors; ... Kidney Neoplasms; Logistic Models; Male; Models, Biological; Multivariate Analysis; ...
The secondary protein structures of most soluble precursor proteins (except for SAA and chromosomal prion protein [Prpc]) have ... and occasionally with neoplasms; it was formerly termed secondary amyloidosis.. Worldwide, AA is the most common systemic ... The precursor protein is the normal- or mutant-sequence transport protein transthyretin (TTR), a transport protein synthesized ... The amyloid beta precursor protein (AβPP), which is a transmembrane glycoprotein, is the precursor protein in beta protein ...
associated with Neoplasm Metastasis; protein:increased expression:lung, lymph node (human). DNA:CNV, amplification:exon (human) ... Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer ( ... protein tyrosine kinase 2. disease_progression. ISO. DNA:CNV::. RGD. PMID:21800286 PMID:20802517. RGD:13825133, RGD:13825141. ... E1A binding protein p300. ISO. CTD Direct Evidence: marker/mechanism. CTD. PMID:22941188. NCBI chr 7:113,108,476...113,178,529 ...
  • This report details the diagnostic value of MAP-2 on tumors with neuroendocrine differentiation and neoplasms derived from the neural crest. (houstonmethodist.org)
  • Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) tumors derived from choroid plexus epithelium that are seen predominantly in children. (medscape.com)
  • [ 2 , 3 ] In adults, they account for less than 1% of primary intracranial neoplasms, whereas choroid plexus tumors represent up to 5% of pediatric brain tumors, and up to 20% of those arising in children aged 1 year and younger. (medscape.com)
  • We report protease-resistant prion protein (PrP res ) in spontaneous lymphoreticular tumors of mice infected with the agent of variant Creutzfeldt-Jakob disease (vCJD). (cdc.gov)
  • Biochemistry of Human Cancer focuses on advances in the application of biochemistry to the study of human cancers, such as neoplastic immunoglobulinopathies, cancer of the bladder, tumors of the neural crest, leukemias and lymphomas, and neoplasms of the bone. (elsevier.com)
  • The remaining chapters look at the role of enzymes and immunoglobulins in cancer, the tryptophan metabolism in cancer of the bladder and the carcinoid syndrome, the link between amino acid metabolism and tumors of the neural crest, and the neoplasms of the digestive tract and the accessory organs (pancreas and liver). (elsevier.com)
  • Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. (bvsalud.org)
  • Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
  • Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
  • [ 4 , 5 ] ) Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
  • Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
  • Pituitary adenomas (especially PRL- and GH-producing tumors) may be part of genetic familial syndromes such as MEN 1, Carney syndrome, or mutant aryl hydrocarbon receptor inhibitor protein (AIP) syndrome. (mhmedical.com)
  • MxA protein expression was significantly higher in tumors with high histologic grade (p=0.023) and high levels of TILs (p=0.002). (e-crt.org)
  • This benign clinical course underscores the importance of accurately distin- guishing these tumors from other glial neoplasms. (vdocuments.mx)
  • Polymorphisms that slightly vary native peptides or inflammatory processes set the stage for abnormal protein folding and amyloid fibril deposition. (medscape.com)
  • Proteins are made from amino acids and are important parts of all cells and tissues. (medlineplus.gov)
  • Serine-threonine Kinase Receptor-Associated Protein is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a Feed-Forward Mechanism. (nih.gov)
  • In addition to a germline mutation in one copy of the gene, a second somatic mutation usually occurs in the normal copy of the gene in cells that give rise to neoplasms. (cdc.gov)
  • Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING. (curehunter.com)
  • Also known as transcriptional activators for their ability to induce transcription of genes into RNA messages, these proteins are essential for the cells to function properly. (news-medical.net)
  • 2020). Protein-altering germline mutations implicate novel genes related to lung cancer development. (who.int)
  • In familial pituitary adenoma patients it is common that no germline defects are found after screening of aryl hydrocarbon receptor interacting protein (AIP) and other genes known to underlie the condition, suggesting the existence of yet unknown predisposition genes. (ox.ac.uk)
  • PAs generally have an excellent prognosis and are classi- fied as WHO grade I neoplasms [5]. (vdocuments.mx)
  • Immunoreactivity of MAP-2 has been demonstrated in most neuroendocrine and neuroectodermal related neoplasms such as small cell carcinoma, large cell neuroendocrine carcinoma, carcinoid tumor of the lung, Merkel cell carcinoma of the skin, medulloblastoma, neurocytoma of the central nervous system, extrapulmonary small cell carcinoma and carcinoid tumor, and malignant melanomas. (houstonmethodist.org)
  • Choroid plexus neoplasms can produce hydrocephalus and increased intracranial pressure by a number of mechanisms, including obstruction of normal cerebrospinal fluid (CSF) flow, overproduction of CSF by the tumor itself, local expansion of the ventricles, or spontaneous hemorrhage. (medscape.com)
  • Secondary neoplasm refers to any of a class of cancerous tumor that is either a metastatic offshoot of a primary tumor, or an apparently unrelated tumor that increases in frequency following certain cancer treatments such as chemotherapy or radiotherapy . (wikipedia.org)
  • In modern English, tumor is used as a synonym for neoplasm (a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears enlarged in size. (wikipedia.org)
  • [12] [13] Some neoplasms do not form a tumor - these include leukemia and most forms of carcinoma in situ . (wikipedia.org)
  • FAP can be detected in various of malignant neoplasms and is associated to tumor cell migration, invasion, and angiogenesis. (centerwatch.com)
  • La expresión anormal de las PROTEINAS ONCOGÉNICAS está implicada en la transformación neoplásica, mientras que la pérdida de la expresión de las PROTEINAS SUPRESORAS DE TUMOR está relacionada con la pérdida del control del crecimiento y progresión de la neoplasia. (bvsalud.org)
  • Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. (bvsalud.org)
  • Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm. (bvsalud.org)
  • The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the table below. (medscape.com)
  • The tumor was positive for OLIG2 and GFAP and negative for BRAF V600E and IDH1 R132H mutant protein immunostains. (vdocuments.mx)
  • [ 5 ] In humans, about 23 different unrelated proteins are known to form amyloid fibrils in vivo. (medscape.com)
  • It then discusses the important biochemical aspects of pulmonary and prostatic neoplasms, including the serum acid and alkaline phosphatase activities of prostatic carcinoma. (elsevier.com)
  • Here we investigated LGR5 expression in colorectal neuroendocrine neoplasms and analyzed the correlation with pathological characteristics. (elsevier.com)
  • The positive correlation between H-score and beta-catenin expression suggests that LGR5 expression might be affected by beta-catenin expression in neuroendocrine neoplasms and especially in NEC. (elsevier.com)
  • 2020). A molecular map of lung neuroendocrine neoplasms. (who.int)
  • His translational research in multiple myeloma and chronic myeloid neoplasms is concerned with the effects of chromatin remodeling on gene expression in cancer cells. (mayo.edu)
  • Chronic myeloid neoplasms. (mayo.edu)
  • Dr. Binder studies the epigenetic determinants of gene expression in chronic myeloid neoplasms associated with mutations in the chromatin-remodeling proteins such as ASXL1. (mayo.edu)
  • In collaboration with Mrinal S. Patnaik, M.B.B.S. , he investigates the suitability of cis-regulatory elements to serve as therapeutic targets in high-risk myeloid neoplasms. (mayo.edu)
  • It has also been described infrequently in other myeloid neoplasms, including chronic myelomonocytic leukemia and myelodysplastic syndrome. (marshfieldlabs.org)
  • Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. (idrblab.net)
  • Potentially-malignant neoplasms include carcinoma in situ . (wikipedia.org)
  • This study goal was to describe and graduate the local and systemic toxicity of intratumoral injections of HSP (Heat Shock Protein) 65 DNA vaccine in advanced-stage head and neck squamous cell carcinoma (SCCHN) patients and to define the highest well tolerated dose for them. (usp.br)
  • We investigated if combined targeting of vascular endothelial growth factor protein and expression might affect hepatocellular carcinoma growth and angiogenesis. (qub.ac.uk)
  • The perirenal infiltration is possible in both types and can be mistaken for common renal neoplasm (Wilms' tumour, clear cell carcinoma) or inflammatory process (renal or perirenal abscess, renal tuberculosis, focal or diffuse nephritis, sarcoidosis or Wegener granulomatosis disease). (springer.com)
  • benign neoplasms , in situ neoplasms , malignant neoplasms , and neoplasms of uncertain or unknown behavior. (wikipedia.org)
  • A neoplasm can be benign , potentially malignant, or malignant ( cancer ). (wikipedia.org)
  • Ovarian neoplasms range from benign to malignant and may be primary or secondary. (appliedradiology.com)
  • Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. (medscape.com)
  • Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands. (medscape.com)
  • A similar proportion of ampullary cancers showed 14-3-3σ and ERM protein expression. (elsevier.com)
  • Expression of 14-3-3σ and ERM protein was more likely in poorly differentiated cancers (p = 0.00005), and their expression was associated with poor survival in univariate analysis (p = 0.09). (elsevier.com)
  • [7] Malignant neoplasms are also simply known as cancers and are the focus of oncology . (wikipedia.org)
  • With a focus on genomically defined cancers, rare diseases and cancer immunotherapy, we are developing transformational medicines rooted in our leading expertise in protein kinases, which are proven drivers of disease. (biospace.com)
  • the emergence of blood cancers known as myeloproliferative neoplasms. (news-medical.net)
  • As a 10-year journey comes to fruition, MUSC Hollings Cancer Center researcher John O'Bryan, Ph.D., and colleagues have demonstrated a new therapeutic way to block a protein that is frequently mutated in cancers. (news-medical.net)
  • In previous studies, high levels of expression of Plu-1 mRNA and PLU-1 protein were detected in breast cancers, while expression in normal adult tissues was detected only in the testis, ovary and transiently in the mammary gland of the pregnant female. (ox.ac.uk)
  • The atomic-level structure of SOCS1 binding to its partner protein JAK could guide the development of drugs that alter disease-causing cell signalling pathways, and may have applications for treating some blood cancers, including leukaemias . (edu.au)
  • This study was undertaken to analyze miR-34a expression in simple endometrial hyperplasia and endometrial cancer, and to evaluate the relationship between expression of miR-34a and p16 and Ki-67 proteins in endometrial cancers. (koreamed.org)
  • These were analyzed for miR-34a expression by quantitative real-time PCR , and the expression of p16 and Ki-67 proteins in endometrial cancers was evaluated by immunohistochemistry. (koreamed.org)
  • Many mechanisms of protein function contribute to amyloidogenesis, including "nonphysiologic proteolysis, defective or absent physiologic proteolysis, mutations involving changes in thermodynamic or kinetic properties, and pathways that are yet to be defined. (medscape.com)
  • apply limited proteolysis-coupled mass spectrometry to assess structural perturbations of the proteome in myeloproliferative neoplasms (MPNs) with mutations in the endoplasmic reticulum chaperone calreticulin. (cell.com)
  • They show that calreticulin mutations perturb the structural landscape of the glycoproteome and provide molecular proof of protein misfolding in calreticulin -mutated MPNs. (cell.com)
  • IDH mutations are seen in 50% of chondrosarcomas, which represent approximately 25% of malignant bone neoplasms. (curesarcoma.org)
  • Together, the germline and somatic mutations result in a complete loss of BAP1 protein function in tumour cells. (cdc.gov)
  • The expression frequencies of many CT antigens have been determined in a variety of neoplasms [ 11 ], but little is known about their expression in human NS tumours. (biomedcentral.com)
  • Overexpression of p53 protein in unicystic ameloblastoma [‎uAB]‎ is denser than in the conventional ameloblastoma [‎cAB]‎ type, indicating increased wild type p53 - suppressing the growth potential of uAB and denoting the early event of neoplastic transformation, probably of a previous odontogenic cyst. (who.int)
  • The book explains the metabolism of purines and pyrimidines in cancer, hypercalcemia in neoplastic disease without evidence of bone metastases, and neoplasms of other organs, such as the pituitary gland, thyroid, testis, and adrenal cortex. (elsevier.com)
  • A negative result does not exclude the presence of a myeloproliferative neoplasm or other neoplastic process. (marshfieldlabs.org)
  • For lymphoid neoplasms, e.g. lymphoma and leukemia , clonality is proven by the amplification of a single rearrangement of their immunoglobulin gene (for B cell lesions) or T cell receptor gene (for T cell lesions). (wikipedia.org)
  • Expression of PIM1 protein in chronic lymphocytic leukemia/small lymphocytic lymphoma. (uchicago.edu)
  • As for a new umbrella category of PTCL, nodal peripheral T-cell lymphoma with T-follicular helper phenotype (NPTCL-TFH) was firstly classified in the 2017 revision of the World Health Organization (WHO) classification of hematolymphoid neoplasms. (researchsquare.com)
  • What is the ICD 10 diagnosis for protein deficiency? (icdcodesinfo.com)
  • The diagnosis of myeloproliferative neoplasm (MPN), The diagnosis of myeloproliferative neoplasm (MPN), unclassifiable, requires that either all 3 criteria are met. (who.int)
  • Risk for Ovarian Malignancy Algorithm (ROMA) and Human epididymis protein 4 (HE4) appear to be promising predictors for epithelial ovarian cancer (EOC), however, conflicting results exist in the diagnostic performance comparison among ROMA, HE4 and CA125. (nih.gov)
  • Malignant neoplasms are commonly called cancer. (wikipedia.org)
  • Rarely there can be a metastatic neoplasm with no known site of the primary cancer and this is classed as a cancer of unknown primary origin . (wikipedia.org)
  • Fibroblast-activation protein (FAP) is a type transmembrane serine protease and is overexpressed in cancer-associated fibroblasts (CAFs). (centerwatch.com)
  • Organized into 18 chapters, this book begins with an overview of the general metabolic features of cancer, with emphasis on the metabolism of lipids, proteins, and carbohydrates. (elsevier.com)
  • Genetic polymorphisms in RNA binding proteins contribute to breast cancer survival. (cdc.gov)
  • Breast cancer is the most common malignant neoplasm affecting women in Bahrain. (who.int)
  • Cette dernière affirmation contraste avec une incidence élevée du Cancer Primitif du Foie (CPF) dans nos pays en voie de développement. (bvsalud.org)
  • Ces deux sont différentes de par leurs caractéristiques socio-économiques.La grande majorité des enquêtés avait une notion du cancer (89%) en général et du CPF (64,4%) en particulier. (bvsalud.org)
  • Walter and Eliza Hall Institute researchers have visualised for the first time how the protein SOCS1 'switches off' cell signalling to dampen immune responses and block cancer growth. (edu.au)
  • The SOCS1 protein binds to JAK proteins to 'switch off' cell signalling, which dampens processes including immune responses and cancer growth. (edu.au)
  • Above: The structure of SOCS1 (red) bound to a JAK protein (beige) could inform the development of new drugs to treat cancer. (edu.au)
  • Dr Kershaw said both SOCS1 and JAK proteins had been implicated in driving diseases including cancer and inflammatory conditions . (edu.au)
  • In particular, overactive JAK signalling is linked to the development of cancer-like conditions called myeloproliferative neoplasms (MPNs) - which include polycythemia vera, essential thrombocythemia and primary myelofibrosis - as well as certain acute childhood leukaemias . (edu.au)
  • In addition, the existence of the four intrinsic subtypes of "luminal A," "luminal B," "HER2-enriched," and "basal-like" has been demonstrated by extensive profiling How to cite this article: Cho N. The molecular subtypes and imaging at the DNA, microRNA, and protein levels by The Cancer Genome Atlas (TCGA) Network [2]. (2medicalcare.com)
  • The major neoplasm worldwide is oral cancer. (bvsalud.org)
  • These proteins play a master role in diverse physiological processes and diseases such as the homeostatic tissue remodeling and cancer 17 . (bvsalud.org)
  • Proto-Oncogene Proteins c-pim-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • This graph shows the total number of publications written about "Proto-Oncogene Proteins c-pim-1" by people in this website by year, and whether "Proto-Oncogene Proteins c-pim-1" was a major or minor topic of these publications. (uchicago.edu)
  • Below are the most recent publications written about "Proto-Oncogene Proteins c-pim-1" by people in Profiles. (uchicago.edu)
  • A positive result is not specific for a particular subtype of myeloproliferative neoplasm and clinicopathologic correlation is necessary in all cases. (marshfieldlabs.org)
  • 1. A referral to p. 57 has been added to the table title, to refer the reader to the Myeloproliferative neoplasm, unclassifiable section, to which this table relates. (who.int)
  • BRAF/KRAS gene sequencing of sebaceous neoplasms after mismatch repair protein analysis. (umassmed.edu)
  • Overexpression of p53 in borderline cAB and malignant ameloblastoma [‎mAB]‎ types might reflect a mutational p53 protein playing an oncogenic role, promoting tumour growth. (who.int)
  • The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is removed. (wikipedia.org)
  • Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS . (bvsalud.org)
  • Signaling via JAK2 activation causes phosphorylation of downstream signal transducers and activators of transcription (STAT) proteins (eg, STAT5) ultimately leading to cell growth and differentiation. (marshfieldlabs.org)
  • We investigated the prognostic significance of aberrant expression of 14-3-3σ and the ERM proteins (Ezrin, radixin, Moesin) in a series of invasive periampullary adenocarcinomas including 300 infiltrating pancreatic adenocarcinomas, 54 ampullary adenocarcinomas, and 33 noninvasive intraductal papillary mucinous neoplasms from patients who underwent pancreaticoduodenal resection at The Johns Hopkins Hospital, Baltimore, MD, between 1991 and 2003. (elsevier.com)
  • Unresectable appendiceal mucinous neoplasms (AMNs) with extensive peritoneal dissemination cause significant morbidity and have limited treatment options. (nih.gov)
  • Nine JAK inhibitors have now been approved by agencies around the world to treat rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, ulcerative colitis, atopic dermatitis, graft versus host disease, and myeloproliferative neoplasms. (nih.gov)
  • Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. (idrblab.net)
  • and squamous cell neoplasm. (nih.gov)
  • The oncogenic proteins they code for result in the inhibition of enzymes normally associated with the removal of repressive chromatin marks. (curesarcoma.org)
  • This lab test measures the types of protein in the fluid (serum) part of a blood sample. (medlineplus.gov)
  • Serum proteins are classified as albumin or globulins. (medlineplus.gov)
  • Albumin is the most abundant protein in the serum. (medlineplus.gov)
  • Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)
  • A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. (ebi.ac.uk)
  • abstract = "Microtubule associated proteins (MAPs) are major components of cytoskeleton proteins associated with microtubule assembly. (houstonmethodist.org)
  • KIAA1549-BRAF fusion is the most common genetic event in pilocytic astrocytoma (PA), and leads to activation of the mitogen activated protein kinase (MAPK) signaling pathway. (vdocuments.mx)
  • We examined LGR5 expression using an RNAscope, a newly developed RNA in situ hybridization technique, with a tissue microarray of the neuroendocrine neoplasm samples. (elsevier.com)
  • Tissue membrane protein is prepared from whole tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. (biochain.com)
  • Further studies are needed to define the relationship between miR-34a expression and tissue specific protein expression. (koreamed.org)
  • Microtubule associated protein-2 (MAP-2), a component of the MAP family, has been shown to be specifically expressed in neuronally differentiated cells, and has been previously used as a sensitive and specific marker for neurons. (houstonmethodist.org)
  • These proteins either arise from proteins expressed by cells at the deposition site (localized), or they precipitate systemically after production at a local site (systemic). (medscape.com)
  • Yet little is known about these proteins, and it wasn't clear how many activators there might be in human cells - until now. (news-medical.net)
  • Among the cell cycle-related proteins, we found that expression of CDC25A was upregulated in MCS and displayed a time-dependent decrease during the transition from MCS to monolayer adherent cells. (jcancer.org)
  • To address this, we analysed the pattern of expression and localisation of this protein in mouse testicular cells during postnatal development and adulthood. (ox.ac.uk)
  • BioChain's membrane proteins are prepared from a large variety of documented and compliant quality tissues, including normal and diseased tissues from human and other species. (biochain.com)
  • Thromboembolic events (TE) are the most common complications of myeloproliferative neoplasms (MPN). (aacrjournals.org)
  • CAFs are the predominant component in the stroma of epithelial neoplasms. (centerwatch.com)
  • Contrasting information was derived through a literature review by Louredo et al, which indicated that in pediatric patients, most salivary gland neoplasms (75.4%) are malignant. (medscape.com)
  • The protein is stored in a buffer with protease inhibitor cocktail. (biochain.com)
  • 8. Participants who have received a prior ataxia telangiectasia and Rad3-related protein (ATR) inhibitor. (who.int)
  • Orthologous to human STRAP (serine/threonine kinase receptor associated protein). (nih.gov)
  • Serine threonine kinase receptor associated protein regulates early follicle development in the mouse ovary. (nih.gov)
  • (1) This gene fusion codes for a chimeric protein, BCR-ABL, which is associated with the uncontrolled activity of ABL tyrosine kinase (TK). (scielo.br)
  • Identification of a novel protein kinase Cδ-Smac complex that dissociates during paclitaxel-induced cell death. (lu.se)
  • Dr. O'Shea is being recognized for his work with the signaling protein JAK3 (Janus Kinase 3). (nih.gov)
  • Mechanistically, Wnt7a induced cellular senescence via inactivation of S-phase kinase-associated protein 2, an important alternate regulator of cellular senescence. (arizona.edu)