Neoplasm metastasis. Medical search

The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.

Tumors or cancer of the LUNG.

Tumors or cancer of the LIVER.

Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

Ability of neoplasms to infiltrate and actively destroy surrounding tissue.

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Tumors or cancer of the SKIN.

Tumors or cancer of the human BREAST.

A cell line derived from cultured tumor cells.

Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

A malignant epithelial tumor with a glandular organization.

Tumors or cancers of the KIDNEY.

A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

Experimental transplantation of neoplasms in laboratory animals for research purposes.

Tumors or cancer of the THYROID GLAND.

Neoplasms containing cyst-like formations or producing mucin or serum.

Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)

Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.

The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Tumors or cancer of the STOMACH.

Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.

Tumors or cancer of the COLON.

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.

They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.

Tumors or cancer of the PROSTATE.

A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)

The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.

An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.

Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.

Tumors or cancer of the SPLEEN.

Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.

DNA present in neoplastic tissue.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.

Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.

The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.

Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.

A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.

Tumors or cancer of the EYE.

A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)

Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.

Tumors or cancer of the PAROTID GLAND.

Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.

A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.

Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.

Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.

An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.

The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.

Tumors or cancer of the PERITONEUM.

Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.

Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.

Transplantation between animals of different species.

Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.

Tumors or cancer of the APPENDIX.

A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)

Surgical excision of one or more lymph nodes. Its most common use is in cancer surgery. (From Dorland, 28th ed, p966)

Tumors or cancer of the ENDOCRINE GLANDS.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

The local implantation of tumor cells by contamination of instruments and surgical equipment during and after surgical resection, resulting in local growth of the cells and tumor formation.

Excision of all or part of the liver. (Dorland, 28th ed)

Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.

Tumors or cancer of the INTESTINES.

Neoplasms of the bony part of the skull.

Tumors or cancer of the MOUTH.

Experimentally induced tumors of the LIVER.

Tumors or cancer of the BILE DUCTS.

Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.

Tumors or cancer of the SALIVARY GLANDS.

Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).

Tumors or cancer of the UTERUS.

A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)

A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.

Tumors or cancer of the TONGUE.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

A benign epithelial tumor with a glandular organization.

Tumors or cancer of the RECTUM.

Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.

Tumors or cancer of the MANDIBLE.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.

Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition.

Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.

An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)

Tumors or cancer of the NOSE.

A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.

Elements of limited time intervals, contributing to particular results or situations.

Exfoliate neoplastic cells circulating in the blood and associated with metastasizing tumors.

Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.

A family of nucleotide diphosphate kinases that play a role in a variety of cellular signaling pathways that effect CELL DIFFERENTIATION; CELL PROLIFERATION; and APOPTOSIS. They are considered multifunctional proteins that interact with a variety of cellular proteins and have functions that are unrelated to their enzyme activity.

A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)

A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)

Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.

Tumors or cancer of the ESOPHAGUS.

Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.

Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.

Surgery to remove one or more NEOPLASM METASTASES.

A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.

Tumors or cancer of the BRONCHI.

Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)

Tumors or cancer of the URINARY BLADDER.

Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.

Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.

A general term for various neoplastic diseases of the lymphoid tissue.

Tumors or cancer of the DUODENUM.

Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.

Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.

Cancer or tumors of the MAXILLA or upper jaw.

Tumors or cancer of the THYMUS GLAND.

A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.

In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.

Tumors or cancer of the ADRENAL GLANDS.

Neoplasms composed of more than one type of neoplastic tissue.

Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Adherence of cells to surfaces or to other cells.

The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Tumors or cancer of the gallbladder.

Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).

A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)

Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Tumors or cancer of the MEDIASTINUM.

Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.

Tumors or cancer of the UVEA.

RNA present in neoplastic tissue.

A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.

A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)

Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.

A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.

Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.

Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.

Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.

Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.

A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)

Area of the human body underneath the SHOULDER JOINT, also known as the armpit or underarm.

Neoplasms of the bony orbit and contents except the eyeball.

The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.

Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

A diagnostic procedure used to determine whether LYMPHATIC METASTASIS has occurred. The sentinel lymph node is the first lymph node to receive drainage from a neoplasm.

In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.

The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.

An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.

The formation of LYMPHATIC VESSELS.

Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.

A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)

Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)

Tumors or cancer of the pelvic region.

An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.

Surgical removal of the pancreas. (Dorland, 28th ed)

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

The exposure of the head to roentgen rays or other forms of radioactivity for therapeutic or preventive purposes.

Tumors or cancer located in bone tissue or specific BONES.

Tumors or cancer of the NASOPHARYNX.

A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)

Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Tumors or cancers of the ADRENAL CORTEX.

Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.

Tumors or cancer of the VAGINA.

A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)

Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.

Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).

A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.

The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)

Surgical removal of the thyroid gland. (Dorland, 28th ed)

Dissection in the neck to remove all disease tissues including cervical LYMPH NODES and to leave an adequate margin of normal tissue. This type of surgery is usually used in tumors or cervical metastases in the head and neck. The prototype of neck dissection is the radical neck dissection described by Crile in 1906.

Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)

Tumors or cancer of the anal gland.

A widely expressed transmembrane glycoprotein that functions as a METASTASIS suppressor protein. It is underexpressed in a variety of human NEOPLASMS.

Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.

Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.

The milieu surrounding neoplasms consisting of cells, vessels, soluble factors, and molecules, that can influence and be influenced by, the neoplasm's growth.

Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)

A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.

Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).

Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis. (1/13013)

The Met tyrosine kinase - the HGF receptor - induces cell transformation and metastasis when constitutively activated. Met signaling is mediated by phosphorylation of two carboxy-terminal tyrosines which act as docking sites for a number of SH2-containing molecules. These include Grb2 and p85 which couple the receptor, respectively, with Ras and PI 3-kinase. We previously showed that a Met mutant designed to obtain preferential coupling with Grb2 (Met2xGrb2) is permissive for motility, increases transformation, but - surprisingly - is impaired in causing invasion and metastasis. In this work we used Met mutants optimized for binding either p85 alone (Met2xPI3K) or p85 and Grb2 (MetPI3K/Grb2) to evaluate the relative importance of Ras and PI 3-kinase as downstream effectors of Met. Met2xPI3K was competent in eliciting motility, but not transformation, invasion, or metastasis. Conversely, MetP13K/Grb2 induced motility, transformation, invasion and metastasis as efficiently as wild type Met. Furthermore, the expression of constitutively active PI 3-kinase in cells transformed by the Met2xGrb2 mutant, fully rescued their ability to invade and metastasize. These data point to a central role for PI 3-kinase in Met-mediated invasiveness, and indicate that simultaneous activation of Ras and PI 3-kinase is required to unleash the Met metastatic potential. (+info)

Control of metastasis by Asn-linked, beta1-6 branched oligosaccharides in mouse mammary cancer cells. (2/13013)

Studies in cell lines and malignant human tissues have shown that increased cell-surface Asn-linked beta1-6(GlcNAcbeta1-6Man) branching is associated with increased tumorigenic and metastatic properties. In this study, three mouse mammary cancer cell lines were transfected with an expression vector containing the mouse cDNA for N-acetylglucosaminyltransferase V (GlcNAcT-V EC 2.4.1.155), the glycosyltransferase responsible for initiating beta1-6 branching on Asn-linked carbohydrates. The cell lines were screened for increased cytotoxicity to L-PHA, a lectin specific for beta1-6 branching structures. Cell lines exhibiting increased L-PHA cytotoxicity expressed increased levels of beta1-6 branching structures. Northern blots detected the presence of GlcNAcT-V transcribed from the expression vector in the L-PHA sensitive cell lines. After injection into the tail veins of mice, transfected cell lines with increased beta1-6 branching on the cell surface formed elevated levels of lung tumors relative to control transfected cell lines (P < 0.002). Western blots of membrane proteins from GlcNAcT-V transfected and control cells probed with the lectins DSA and WGA did not show an increase in polyN-acetyllactosamine and sialic acid content in the transfected cell lines. These results demonstrate that a specific increase in beta1-6 branching due to an elevation in GlcNAcT-V expression increases metastatic potential. (+info)

Role of thrombin receptor in breast cancer invasiveness. (3/13013)

Invasion, the ability of an epithelial cancer cell to detach from and move through a basement membrane, is a central process in tumour metastasis. Two components of invasion are proteolysis of extracellular matrix and cellular movement through it. A potential promoter of these two processes is thrombin, the serine proteinase derived from the ubiquitous plasma protein prothrombin. Thrombin promotes the invasion of MDA-MB231 breast tumour cells (a highly aggressive cell line) in an in vitro assay. Invasion by MDA-MB436 and MCF-7 cells, less aggressive cell lines, is not promoted by thrombin. Thrombin, added to the cells, is a stimulator of cellular movement; fibroblast-conditioned medium is the chemotaxin. Thrombin-promoted invasion is inhibited by hirudin. Stimulation of invasion is a receptor-mediated process that is mimicked by a thrombin receptor-activating peptide. Thrombin has no effect on chemotaxis in vitro. Thrombin receptor is detectable on the surface of MDA-MB231 cells, but not on the other two cell lines. Introduction of oestrogen receptors into MDA-MB231 cells by transfection with pHEO had no effect on thrombin receptor expression, in the presence or absence of oestradiol. This paper demonstrates that thrombin increases invasion by the aggressive breast cancer cell line MDA-MB231 by a thrombin receptor-dependent mechanism. (+info)

Development of a sensitive, specific reverse transcriptase polymerase chain reaction-based assay for epithelial tumour cells in effusions. (4/13013)

We developed a sensitive and specific method for the detection of epithelial cancer cells in effusions with a two-stage molecular-based assay which combined enrichment for cancer cells by immunomagnetic bead selection and reverse transcriptase polymerase chain reaction (RT-PCR) detection of epithelial glycoprotein 2 (EGP-2) RNA. Preliminary experiments indicated that immunobead selection was essential to avoid occasional false-positive RT-PCR results, and this method detected ten breast cancer cells electively added to 10(7) cytologically negative effusion cells. We studied 110 cases of pleural (n = 68) and peritoneal (n = 42) effusions (30 from patients with known carcinoma and 80 from those without known carcinoma), and the results were compared with cytological findings. Of 18 effusions that were cytologically positive or suspicious for malignant cells, 17 (94%) were positive for EGP-2 RNA (the one negative sample was from a patient who recently received combination chemotherapy). Of 92 cytologically negative samples, 11 (12%) were positive for EGP-2, including six patients with a history of previous or current carcinoma. Our method appears to be highly specific and increases the sensitivity of detection of malignant cells; it may be a useful adjunct to routine cytopathological examination. (+info)

Expression of tissue factor in non-small-cell lung cancers and its relationship to metastasis. (5/13013)

Tissue factor (TF) is an initiator of the extrinsic cascade of blood coagulation. Although recent studies have revealed a relationship between metastatic properties and TF expression in some neoplastic cells, the significance of TF in lung cancer, especially in non-small-cell lung cancer (NSCLC), is still unclear. In this study, TF was detected in NSCLC cell lines by functional study, Western blot analysis and immunocytochemical staining. TF levels in eight NSCLC cell lines were also quantitated by enzyme-linked immunosorbent assay (ELISA), and TF expression was evaluated in 55 specimens of surgically resected NSCLCs. NSCLC cell lines derived from metastatic lesions produced high levels of TF (48.3+/-23.5 ng 10(-6) cells, mean +/- s.e.m.), whereas those derived from primary lesions produced low levels of TF (0.2+/-0.1 ng 10(-6) cells). Immunohistochemical studies disclosed significantly stronger staining for TF in cells from NSCLC patients with metastasis than in those without metastasis. Among the 28 patients with metastasis, ten were strongly positive, 16 were moderately positive and two were negative for TF. In contrast, among the 27 patients without metastasis, only two were strongly positive, 18 were moderately positive and seven were negative for TF. Therefore, malignant cells from patients with lung cancer produce various levels of TF, and TF may play an important role in the metastatic process. (+info)

Peritoneal cytology in the surgical evaluation of gastric carcinoma. (6/13013)

Many patients undergoing surgery for gastric carcinoma will develop peritoneal metastases. A method to identify those patients at risk of peritoneal recurrence would help in the selection of patients for adjuvant therapy. Peritoneal cytology has received little attention in the West, but may prove a useful additional means of evaluating patients with gastric cancer. The aims of this study were to evaluate sampling techniques for peritoneal cytology in patients with gastric cancer, to assess the prognostic significance of free peritoneal malignant cells and to discover the effect of the operative procedure on dissemination of malignant cells. The study is based on 85 consecutive patients undergoing surgical treatment of gastric cancer and followed up for 2 years or until death. Peritoneal cytology samples were collected at laparoscopy, and at operation prior to resection by intraperitoneal lavage and serosal brushings. After resection, samples were taken by peritoneal lavage, imprint cytology of the resected specimen and post-operatively by peritoneal irrigation via a percutaneous catheter. Malignant cells were diagnosed by two independent microscopists. Preoperative peritoneal lavage yielded malignant cells in 16 out of 85 cases (19%). The yield of free malignant cells was increased by using serosal brushings (by four cases) and imprint cytology (by two cases); all of the cases had evidence of serosal penetration. One serosa-negative case exhibited positive cytology in the post-resection peritoneal specimen in which the preresection cytology specimen was negative. Survival was worse in the cytology-positive group (chi2 = 25.1; P< 0.0001). Among serosa-positive patients, survival was significantly reduced if cytology was positive, if cases yielded by brushings and imprint cytology were included (log-rank test = 8.44; 1 df, P = 0.004). In conclusion, free peritoneal malignant cells can be identified in patients with gastric cancer who have a poor prognosis; the yield can be increased with brushings and imprint cytology in addition to conventional peritoneal lavage. Evaluation of peritoneal cytology by these methods may have a role in the selection of patients with the poorest prognosis who may benefit most from adjuvant therapy. (+info)

Expression of pyrimidine nucleoside phosphorylase mRNA plays an important role in the prognosis of patients with oesophageal cancer. (7/13013)

To clarify the significance of the expression of pyrimidine nucleoside phosphorylase (PyNPase) mRNA as a predictive factor for the prognosis of patients with oesophageal carcinoma, the PyNPase mRNA in the tumours and normal tissues from 55 resected cases of oesophageal carcinoma was examined by a reverse transcription polymerase chain reaction (RT-PCR). As a result, a positive correlation was observed between the tumour/normal (T/N) ratio of the expression of PyNPase mRNA by RT-PCR and that of the enzyme activity of PyNPase based on the findings of an enzyme linked immunosolvent assay (r = 0.594, P = 0.009). The T/N ratio of the expression of PyNPase mRNA was significantly higher in the cases with lymph vessel invasion (P = 0.013), lymph node metastasis (P = 0.0016), and an advanced stage of the disease (P = 0.021) than those without these factors. The patients with a higher T/N ratio of PyNPase mRNA showed significantly worse prognosis than those with a lower T/N ratio (P = 0.023 with log-rank tests). A multivariate analysis for the cumulative survival rates revealed that a high T/N ratio of the expression of PyNPase mRNA was independently related to a poor prognosis. These findings suggested that the determination of PyNPase mRNA by RT-PCR thus appears to be a new useful parameter for identifying both a poor prognosis and a highly malignant potential of oesophageal carcinoma. (+info)

Phase I study of escalating doses of edatrexate in combination with paclitaxel in patients with metastatic breast cancer. (8/13013)

Motivated by the observation of preclinical synergy, a Phase I dose escalation study of edatrexate in combination with a 3-h paclitaxel infusion was performed in patients with advanced breast cancer to determine the maximum tolerated dose (MTD) of edatrexate and the toxicities associated with this combination and to report preliminary observations of efficacy with this novel combination. Thirty-six patients were enrolled in this Phase I trial. Thirty-five eligible patients were treated every 21 days in cohorts of at least three patients and were assessable for toxicity. One patient was ineligible due to hyperbilirubinemia. Stepwise dose escalations of edatrexate were administered until grade >3 nonhematological dose-limiting toxicities were reported. The initial dose level of edatrexate was 180 mg/m2; subsequent cohorts were treated with escalating doses of edatrexate (210, 240, 270, 300, 350, and 400 mg/m2). Edatrexate was administered by i.v. infusion over 1 h. Paclitaxel was administered 24 h later at a fixed dose of 175 mg/m2 as a 3-h infusion with standard dexamethasone, diphenhydramine, and cimetidine premedication. The MTD of edatrexate was reached at the 350 mg/m2 level in this study. Grade 3 diarrhea was seen in one patient at the 300 and 400 mg/m2 dose levels, requiring dose reductions. Two patients experienced grade 4 stomatitis at the 400 mg/m2 dose level and also required dose reduction, establishing the MTD as 350 mg/m2. Grade 3 nausea and vomiting were noted in two of three patients at the highest dose level. Of 35 patients, 4 patients reported grade 3 myalgias and 1 patient reported grade 3 neurosensory complaints, which were seen mostly at the 350 and 400 mg/m2 dose levels; however, 1 patient reported grade 3 myalgias at 180 mg/m2. No cumulative neurotoxicity was observed, and no patient experienced an allergic reaction to paclitaxel. In 23 patients with bidimensionally measurable disease, there were four complete (17%) and seven partial responses, with an overall response rate of 48% (95% confidence interval, 27-69%). All of the responses were seen in patients who had not received prior chemotherapy for stage IV disease. The median duration of response was not assessable because many responding patients went on to receive high-dose chemotherapy treatment with stem cell support. The combination of edatrexate and paclitaxel for treatment of metastatic breast cancer is a feasible and safe regimen. The MTD of edatrexate was 350 mg/m2 when combined with a 3-h infusion of paclitaxel (175 mg/m2) given 24 h later. Activity was noted even among patients who had relapsed shortly after receiving methotrexate- and/or doxorubicin-containing adjuvant regimens. Additional studies evaluating the sequences and dosing schema for this combination are warranted to improve the response proportion and define the duration of the response. (+info)

"Choroidal Metastasis - The Eye Cancer Network". Archived from the original on 2010-09-29. Retrieved 2010-03-10. "Choroidal ... Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be ... Choroidal hemangioma Choroidal melanoma Choroidal metastasis Choroidal nevus Choroidal osteoma Ciliary body melanoma The nevus ...

https://en.wikipedia.org/wiki/Eye_neoplasm

Thyroid metastasis from lung adenocarcinoma (a, b). Some metastatic tumor cells (right) are positive for thyroglobulin due to ... Thyroid neoplasm is a neoplasm or tumor of the thyroid. It can be a benign tumor such as thyroid adenoma, or it can be a ... Thyroid neoplasm might be classified as benign or malignant.[citation needed] Thyroid adenoma is a benign neoplasm of the ... The first step in diagnosing a thyroid neoplasm is a physical exam of the neck area. If any abnormalities exist, a doctor needs ...

https://en.wikipedia.org/wiki/Thyroid_neoplasm

Neoplasm Metastasis Cancer Brain tumor Tse V (10 November 2009). "Brain Metastasis". Medscape. Retrieved 13 January 2010. " ... The metastasis typically shares a cancer cell type with the original site of the cancer. Metastasis is the most common cause of ... Brain metastases can occur in patients months or even years after their original cancer is treated. Brain metastases have a ... The diagnosis of brain metastases typically follows a diagnosis of a systemic cancer. Occasionally, brain metastases will be ...

https://en.wikipedia.org/wiki/Brain_metastasis

This mass can be detected and removed before transformation and metastasis. The tumor is often detected by imaging such as ... Hürthle cell neoplasm is a rare tumor of the thyroid, typically seen in women between the ages of 70 and 80 years old. When ... Ayana Suzuki, C.T., Andrey Bychkov, M.D., Ph.D. "Hürthle cell neoplasm". Pathology Outlines.{{cite web}}: CS1 maint: multiple ... References for findings: - Ayana Suzuki, C.T., Andrey Bychkov, M.D., Ph.D. "Hürthle cell neoplasm". Pathology Outlines.{{cite ...

https://en.wikipedia.org/wiki/Hürthle_cell_neoplasm

The most common malignant neoplasms (cancers) of the liver are metastases; those arising from colorectal cancer are among the ... Most hepatectomies are performed for the treatment of hepatic neoplasms, both benign or malign. Benign neoplasms include ... Prior to surgery, cytotoxic agents such as oxaliplatin given systemically for colorectal metastasis, or chemoembolization for ... repeat resections for reincident colorectal cancer metastases).[citation needed] Liver surgery is safe when performed by ...

https://en.wikipedia.org/wiki/Hepatectomy

breast cancer metastasis neoplasm chemotherapy Mouse models of breast cancer metastasis Phyllodes tumour John's Hopkins. " ... Brain metastases. Brain metastases occur in up to 10-15% of breast-cancer patients, and often (but not always) occur late in ... Bone metastases. The bones are a very common site of metastatic disease from breast cancer, and bone metastases can cause ... In breast cancer, spinal-cord compression occurs when a bone metastasis or spinal metastasis begins to push on the spinal cord ...

https://en.wikipedia.org/wiki/Metastatic_breast_cancer

... of people already have metastases. Small-cell carcinoma is an undifferentiated neoplasm composed of primitive-appearing cells. ... after metastasis. Symptomatic metastasis of SCCP to the brain is rare, and carries a poor prognosis. TP53 is mutated in 70 to ... pain from liver or bone metastases, or for treatment of brain metastases, which, in small-cell lung carcinoma, typically have a ... Of note, temozolomide yielded a response rate of 38% for brain metastases due to SCLC. In a clinical trial of 50 patients, ...

https://en.wikipedia.org/wiki/Small-cell_carcinoma

In its malignant form, metastasis to the lungs, liver, brain, and extremities may occur. It most commonly manifests itself in ... Hemangiopericytoma is a rare vascular neoplasm, or abnormal growth, that may either be benign or malignant. ...

https://en.wikipedia.org/wiki/Pericyte

Of further relevance is that this tumour is more commonly calcified than any other kidney neoplasm. Surgery is curative and no ... There is so far no evidence of metastases or local recurrence. Metanephric adenoma is diagnosed histologically. The tumours can ... the frequent gain of chromosomes 7 and 17 and losses of the Y chromosome that are typical of papillary renal cell neoplasms, ...

https://en.wikipedia.org/wiki/Metanephric_adenoma

Occasionally, a bone metastasis of a GCCL could potentially be mistaken for a primary giant-cell tumor of bone - the latter ... Spivach A, Borea B, Bertoli G, Daris G (July 1976). "[Primary lung neoplasm of rare incidence: giant cell carcinoma]". Minerva ... Within the small bowel, the jejunum seems to be a preferred site for metastasis of GCCL. GCCL also often metastasizes to bone, ... Hagihara N, Abe T, Wakamiya T, Sugita Y, Watanabe M, Tabuchi K (2010). "A case of brain metastasis from pulmonary giant cell ...

https://en.wikipedia.org/wiki/Giant-cell_carcinoma_of_the_lung

"A case of ovarian metastasis of gallbladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of ...

https://en.wikipedia.org/wiki/Signet_ring_cell

... also confirms the genetic heterogeneity between the primary neoplasm of breast cancer patients and their respective metastases ... Metastasis is a process of migration of tumour cells from the primary cancer site to a distant location where the cancer cells ... When looking at metastasis, it is difficult to determine the precise location as well as its frequency. Another issue revolves ... MMTV-PyMT is the model of breast cancer metastasis, in which MMTV-LTR is used to drive the expression of mammary gland specific ...

https://en.wikipedia.org/wiki/Mouse_models_of_breast_cancer_metastasis

Calcifications are commonly present, as may be seen with slow-growing neoplasms. Although ASPS displays a relatively indolent ... course, the ultimate prognosis is poor and is often characterized by late metastases. ASPS is an extremely rare cancer. While ...

https://en.wikipedia.org/wiki/Alveolar_soft_part_sarcoma

... parotid gland neoplasms or metastases. Sometimes, the facial nerve cannot be preserved during resection of these tumours.[ ...

https://en.wikipedia.org/wiki/Smile_surgery

v t e (Articles with short description, Short description is different from Wikidata, Sarcoma, All stub articles, Neoplasm ... "Left atrial myxosarcoma with previously detected intestinal metastasis". Tex Heart Inst J. 34 (1): 122-5. PMC 1847916. PMID ...

https://en.wikipedia.org/wiki/Myxosarcoma

Exceptions include local or metastasis-directed therapy with radiation may be used for advanced tumors with limited metastasis ... "Male Genitals - Prostate Neoplasms". Pathology study images. University of Virginia School of Medicine. Archived from the ... The route of metastasis to bone is thought to be venous, as the prostatic venous plexus draining the prostate connects with the ... Sclerosis of the bones of the thoracic spine due to prostate cancer metastases (CT image) Sclerosis of the bones of the ...

https://en.wikipedia.org/wiki/Prostate_cancer

... neoplasms can be separated into Hürthle cell adenomas and carcinomas, which are respectively benign and malignant ... On few occasions, patients with Hürthle cell carcinoma have distant metastases in the lungs or surrounding bones. Hürthle cell ... Some scientists have identified these mutations as deletions in the mitochondrial DNA of Hürthle cells found in neoplasms and ... References for findings: - Ayana Suzuki, C.T., Andrey Bychkov, M.D., Ph.D. "Hürthle cell neoplasm". Pathology Outlines.{{cite ...

https://en.wikipedia.org/wiki/Hürthle_cell

... more commonly a metastasis; or very rarely a primary neoplasm. The most common type is a sarcoma followed by lymphoma, ... Retroperitoneal fibrosis Retroperitoneal lymph node dissection It is also possible to have a neoplasm in this area, ...

https://en.wikipedia.org/wiki/Retroperitoneal_space

... or metastases of other tumours. Often, since facial neoplasms have such an intimate relationship with the facial nerve, ... While this will inevitably lead to facial paralysis, safe removal of a malignant neoplasm is vital for patient survival. After ... Common culprits are facial neuromas, congenital cholesteatomas, hemangiomas, acoustic neuromas, parotid gland neoplasms, ...

https://en.wikipedia.org/wiki/Facial_nerve_paralysis

... benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. Malignant neoplasms ... Tumors in the vagina may also be metastases (malignant tissue that has spread to the vagina from other parts of the body). ... A neoplasm is an abnormal growth of tissue that usually forms a tissue mass. Vaginal neoplasms may be solid, cystic or of mixed ... p. Neoplasm. ISBN 978-0781733908. "NCI Dictionary of Cancer Terms - Neoplasm". National Cancer Institute. 2011-02-02. Retrieved ...

https://en.wikipedia.org/wiki/List_of_vaginal_tumors

... which may be benign neoplasms) or else a malignant neoplasm (cancer). These neoplasms are also indicated, in the diagram below ... Cancer stem cell hypothesis might explain such phenomena as metastasis and remission. The monoclonal model of cancer and the ... Neoplasms are mosaics of different mutant cells with both genetic and epigenetic changes that distinguish them from normal ... In this way, a population of mutant cells, called a clone, can expand in the neoplasm. Clonal expansion is the signature of ...

https://en.wikipedia.org/wiki/Somatic_evolution_in_cancer

A pattern of multiple small nodular metastases has been described as miliary carcinosis which has a radiographic appearance ... Young, Robert H. (2004). "Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms". Seminars ... Currall, Verity A.; Dixon, John H. (2008). "Synovial Metastasis". The Journal of Arthroplasty. 23 (4): 631-636. doi:10.1016/j. ... Carcinosis, or carcinomatosis, is disseminated cancer, forms of metastasis, whether used generally or in specific patterns of ...

https://en.wikipedia.org/wiki/Carcinosis

... neoplasms is limited to lesions with no risk of nodal metastasis. Either polypectomy or endoscopic mucosal resection (EMR) is ... The resected size and shape can be controlled, en bloc resection is possible even in a large neoplasm, and neoplasms with ... So this technique can be applied to the resection of complex neoplasms such as large neoplasms, ulcerative non-lifting ... especially for large or ulcerative neoplasms. Recently, the ESD technique is applied to esophageal or colorectal neoplasms in ...

https://en.wikipedia.org/wiki/Endoscopic_submucosal_dissection

If metastases are present, signs and symptoms associated with the metastatic disease and more severe symptoms may be present. ... size or metastases of tumor and prior chemotherapy. Each risk factors are rated at levels 0-4 scores. The numbers are then ...

https://en.wikipedia.org/wiki/Trophoblastic_neoplasm

... but an infiltrating neoplasm makes it difficult to say where the tumor ends and the healthy tissue starts. metastasis (spread ... Neoplasms will often show as differently colored masses (also referred to as processes) in CT or MRI results.[citation needed] ... More generally a neoplasm may cause release of metabolic end products (e.g., free radicals, altered electrolytes, ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ...

https://en.wikipedia.org/wiki/Brain_tumor

Tumors that express keratin include carcinomas, thymomas, sarcomas and trophoblastic neoplasms. Furthermore, the precise ... while metastases of colorectal carcinomas express CK20, but not CK7. List of cutaneous conditions caused by mutations in ... expression-pattern of keratin subtypes allows prediction of the origin of the primary tumor when assessing metastases. For ...

https://en.wikipedia.org/wiki/Keratin

"Adrenal Metastasis". Cancer, Adrenal Metastasis. StatPearls at National Center for Biotechnology Information. PMID 28722909. ... An adrenal tumor or adrenal mass is any benign or malignant neoplasms of the adrenal gland, several of which are notable for ... Metastasis to one or both adrenal glands is the most common form of malignant adrenal lesion, and the second most common ... Pheochromocytoma is a neoplasm composed of cells similar to the chromaffin cells of the mature adrenal medulla. ...

https://en.wikipedia.org/wiki/Adrenal_tumor

It must be distinguished from Metastasis from the prior tumor or a relapse from it since a secondary malignant neoplasm is a ... Secondary malignant neoplasm is a malignant tumor whose cause is the treatment (usually radiation or chemotherapy) which was ...

https://en.wikipedia.org/wiki/Secondary_malignant_neoplasm

... parotid gland neoplasms, or metastases of other tumors. Other causes like viral, bacterial or fungal infections like chicken ...

https://en.wikipedia.org/wiki/Facial_nerve_decompression

... of cases have had local recurrence whereas some demonstrate regional lymph node or osseous metastasis. The rare neoplasms ... MCS is reported to have a high and continual risk of recurrence of metastasis, some patients experiencing metastasis nearly ... rate of metastasis and mortality in the order of 25%" (Ka, Gnangnon, and Diouf, 2016) with the highest recordings of metastases ... nodal metastasis, and distant metastasis, [respectively]" (Watarai, Amoh, Aki, Takasu, Katsuoka, 2011). In terms of prognosis ...

https://en.wikipedia.org/wiki/Malignant_chondroid_syringoma

In advanced disease, metastases may be present in the abdomen, lungs, or elsewhere. Symptoms of advanced cervical cancer may ... Myung SK, Ju W, Kim SC, Kim H (October 2011). "Vitamin or antioxidant intake (or serum level) and risk of cervical neoplasm: a ...

https://en.wikipedia.org/wiki/Cervical_cancer

... lymph node metastases occurred in 5 cases, and distant tissue metastasis occurred in 9 cases; the metastases occurred only in ... The World Health Organization (2019) classified papillary neoplasms (i.e. benign or cancerous tumors) of the breast into 5 ... 5 cm.) and axillary lymph node metastases (44.2% with no, 4.3% with, and 51.5% with unknown metastases) were treated with ... had no information on metastases) and 5) no cases had metastases to distant tissues. A study of 8 men aged 49 to 88 years ...

https://en.wikipedia.org/wiki/Papillary_carcinomas_of_the_breast

On imaging, multiple hamartomas may look similar to metastases or microabscesses.[citation needed] Observation as there is ... Neoplasm stubs). ...

https://en.wikipedia.org/wiki/Bile_duct_hamartoma

For example, neoplasms characterized by high-grade features, invasive glands and or signet ring cells, are termed ... December 2001). "Surgical debulking and intraperitoneal chemotherapy for established peritoneal metastases from colon and ... Young RH (May 2004). "Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms". Seminars in ... ISBN 978-0-323-35909-2. Sugarbaker PH (January 2006). "New standard of care for appendiceal epithelial neoplasms and ...

https://en.wikipedia.org/wiki/Pseudomyxoma_peritonei

Regression of cancer occurs mainly in soft tissue and osseous metastases. [...] Both of these progestational compounds possess ... "Pharmacology and Clinical Utility of Hormones in Hormone Related Neoplasms". In Alan C. Sartorelli; David G. Johns (eds.). ...

https://en.wikipedia.org/wiki/Bromoketoprogesterone

However, p16 can be expressed in other neoplasms and in several normal human tissues. More than a third of urinary bladder SCCs ... Sinha P, Thorstad WT, Nussenbaum B, Haughey BH, Adkins DR, Kallogjeri D, Lewis JS (January 2014). "Distant metastasis in p16- ... infection and neoplasms of cervical origin. The majority of SCCs of uterine cervix express p16. ...

https://en.wikipedia.org/wiki/P16

Renal epithelial neoplasms have characteristic cytogenetic aberrations that can aid in classification. See also Atlas of ... of chromosome 3 detected with single nucleotide polymorphisms is superior to monosomy 3 for predicting metastasis in uveal ... "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms." Nature 13 Aug 2009; 460, 904-909. Gondek LP, Tiu R, ... Malignant rhabdoid tumors are rare, highly aggressive neoplasms found most commonly in infants and young children. Due to their ...

https://en.wikipedia.org/wiki/Virtual_karyotype

... had metastases to the local lymph nodes, and 8.3% had distant metastases. (In the study 103 individuals, the distant metastasis ... Baranov E, Hornick JL (March 2020). "Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck ... of cases but no patients had lymph node metastasis and only 1 case had distant metastases (the presence of lymph node and ... Oylumlu M, Yildiz A, Ercan S, Oylumlu M, Davutoglu V (2014). "Cardiac metastasis of a low-grade myofibroblastic sarcoma". ...

https://en.wikipedia.org/wiki/Low-grade_myofibroblastic_sarcoma

They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... Metastasis is common in the late stages of cancer and it can occur via the blood or the lymphatic system or both. The typical ... Metastasis is common in the late stages of cancer and it can occur via the blood or the lymphatic system or both. The typical ... For painful bone metastasis, it has been found to be effective in about 70% of patients. Surgery is the primary method of ...

https://en.wikipedia.org/wiki/Cancer

Summy JM, Gallick GE (December 2003). "Src family kinases in tumor progression and metastasis". Cancer and Metastasis Reviews. ... Mitchell RS, Kumar V, Abbas AK, Fausto N (2007). "Chapter 20 - Neoplasms of the Thyroid". Robbins Basic Pathology (8th ed.). ... Yokota J (March 2000). "Tumor progression and metastasis". Carcinogenesis. 21 (3): 497-503. doi:10.1093/carcin/21.3.497. PMID ...

https://en.wikipedia.org/wiki/Oncogene

Ureteral neoplasm, a type of tumor that can be primary, or associated with a metastasis from another site Urethral cancer, ...

https://en.wikipedia.org/wiki/Ureteral_cancer

Abdominal CT or MRI scans as well as chest imaging are done to detect for metastasis. The analysis of tumor markers also helps ... It is a malignant neoplasm and is one of the most treatable and curable cancers, with a survival rate above 95% if discovered ... Low back pain may occur after metastasis to the retroperitoneum. Some cases of seminoma can present as a primary tumour outside ... Stage 3 seminoma is characterized by the presence of metastasis outside the retroperitoneum-the lungs in "good risk" cases or ...

https://en.wikipedia.org/wiki/Seminoma

Artigas C, Otte FX, Lemort M, van Velthoven R, Flamen P (May 2017). "Vertebral Hemangioma Mimicking Bone Metastasis in 68Ga- ... The consideration of VHs as a neoplasm is disputed, due to limited aggressive histopathological features. As such, some authors ... They are formed from benign vasoformative neoplasms of endothelial cells that present as thin-walled vessels infiltrating the ... bone metastasis, Ewing Sarcoma, and spinal dural arteriovenous fistula. Treatment for VHs normally only takes place if a ...

https://en.wikipedia.org/wiki/Vertebral_hemangioma

Malignant CCS tumors are diagnosed based on the individuals personal and family history of CCS, the presence of metastases, and ... Articles with short description, Short description is different from Wikidata, Epidermal nevi, neoplasms, and cysts, Conditions ... Trichofolliculoma Spiradenoma spiradenocarcinoma List of cutaneous conditions List of cutaneous neoplasms associated with ... "Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on ...

https://en.wikipedia.org/wiki/CYLD_cutaneous_syndrome

This is a concern during treatment of brain tumors and brain metastases, especially where there is pre-existing raised ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... A major use of systemic radioisotope therapy is in the treatment of bone metastasis from cancer. The radioisotopes travel ... Many low-dose palliative treatments (for example, radiation therapy to bony metastases) cause minimal or no side effects, ...

https://en.wikipedia.org/wiki/Radiation_therapy

Gynoroentgenologic imaging can detect and diagnose primary neoplasms, metastasis, therapy-related lesions, congenital lesions, ...

https://en.wikipedia.org/wiki/Gynoroentgenology

... neoplasms, and cysts are skin lesions that develop from the epidermal layer of the skin. Aberrant basal cell carcinoma ... Wildervanck syndrome Xanthelasmoidal mastocytosis Zosteriform metastasis Dermatitis is a general term for "inflammation of the ... an overview with emphasis on the myeloid neoplasms". Chem. Biol. Interact. 184 (1-2): 16-20. doi:10.1016/j.cbi.2009.10.009. ... neoplasms invading or aberrantly present in the dermis. Acquired progressive lymphangioma (benign lymphangioendothelioma) Acral ...

https://en.wikipedia.org/wiki/List_of_skin_conditions

Hensiek AE, Kellerman AJ, Hill JT (August 2000). "Spontaneous regression of a solitary cerebral metastases in renal carcinoma ... ISBN 978-0-323-32195-2. Meningeal Neoplasms-Advances in Research and Treatment: 2012 Edition: ScholarlyBrief. ScholarlyEditions ...

https://en.wikipedia.org/wiki/Side_effects_of_cyproterone_acetate

... in cancers is characterized by anaplasia, invasiveness, and metastasis. Malignant tumors are also characterized by ... Uses of "malignant" in oncology include: Malignancy, malignant neoplasm and malignant tumor are synonymous with cancer ...

https://en.wikipedia.org/wiki/Malignancy

MeSH website, tree at: "Pancreatic Neoplasms [C04.588.322.475]",[dead link] accessed 16 October 2014 "Insulinomas". The ... metastases) range from 5 to 30%. Over 99% of insulinomas originate in the pancreas, with rare cases from ectopic pancreatic ...

https://en.wikipedia.org/wiki/Insulinoma

This is a very rare neoplasm accounting for approximately 0.0003% of all tumors and about 2.5% of all external ear neoplasms. ... The local reoccurrence rate is 49% and the distant metastasis rate is 13%. With local reoccurrence being at 49%, follow-up is ... Ceruminous adenocarcinoma is a malignant neoplasm derived from ceruminous glands of the external auditory canal. This tumor is ... Benign and malignant glandular neoplasms". Archives of Otolaryngology. 106 (1): 13-19. doi:10.1001/archotol.1980.00790250015004 ...

https://en.wikipedia.org/wiki/Ceruminous_adenocarcinoma

Specifically, metastasis occurs most frequently in the lungs followed by bone and the brain, exhibiting a wide range of ... Table 3 from: Weiss, Lawrence M.; Gelb, Arnold B.; Jeffrey Medeiros, L. (1995). "Adult Renal Epithelial Neoplasms". American ... of all kidney neoplasms. Based on its morphological features, PRCC can be classified into two main subtypes, which are type 1 ( ... and metastasis. Type 2 PRCC is associated with irregularity of several signaling pathways, which includes CDKN2A silencing, ...

https://en.wikipedia.org/wiki/Papillary_renal_cell_carcinoma

Metastasis occurs in approximately 50% of cases with the most frequent occurrence in the lungs, which is common site of ... EMC shows the smallest morphological variation between the tumors among all myxoid soft tissue neoplasms. The myxoid matrix has ... There have been rare cases of spontaneous regression of pulmonary metastases without any treatment. As with all these subgroups ... Extraskeletal myxoid chondrosarcoma (EMC) is a rare low-grade malignant mesenchymal neoplasm of the soft tissues, that differs ...

https://en.wikipedia.org/wiki/Extraskeletal_myxoid_chondrosarcoma

Common sites for metastasis include lymph nodes, the liver, spleen, lung, skeletal muscle, blood vessels and parotid salivary ... Sarcoids are the most common type of skin neoplasm and are the most common type of cancer overall in horses. Squamous-cell ... Before treatment of squamous-cell carcinoma (SCC) is initiated, evidence of metastasis must be determined either by palpation ... metastasis) and location of the tumor. Not all cancers metastasize and some can be cured or mitigated by surgical removal of ...

https://en.wikipedia.org/wiki/Skin_cancer_in_horses

Distant metastasis (pM) "M0: No distant metastasis" "M1: Distant metastasis" Since many, if not most, anal cancers derive from ... Chemotherapy commonly used is similar to other squamous cell epithelial neoplasms, such as platinum analogues, anthracyclines ... Median survival rates for people with distant metastases range from 8 to 34 months. Surgical resection with permanent ... " "N1: Metastasis in inguinal, mesorectal, internal iliac or external iliac nodes" "N1a: Metastasis in inguinal, mesorectal or ...

https://en.wikipedia.org/wiki/Anal_cancer

A ureteral neoplasm is a type of tumor that can be primary, or associated with a metastasis from another site. Treatment may ... September 2000). "Gastric cancer recognized by metastasis to the ureter". Gastric Cancer. 3 (2): 102-105. doi:10.1007/ ...

https://en.wikipedia.org/wiki/Ureteral_neoplasm

Neoplasm Metastasis , Liver Metastases , secondary cancer , metastases , Prostate Disorders , Prostatic disorder , Malignant ... neoplasm of prostate , PSMA-PET , Bone Metastases , prostate tumors , Metastasis , metastatic tumor , prostate tumor , Prostate ... Metastasis, secondaries, Bone Metastases, Prostate Disorders, Malignant neoplasm of prostate, Liver Metastases, Prostatic ... Brain Metastases, prostate tumors, metastases, Prostate Cancer, Early, Recurrent, secondary cancer, ...

https://www.centerwatch.com/clinical-trials/listings/278297/68ga-psma-pet-in-the-prostate-cancer/?&geo_lat=34.341574&geo_lng=108.93977&radius=10&place=Xi

Neoplasm Metastasis. Get access to cutting edge treatment via RBS2418. View duration, location, compensation, and staffing ... Patient Self-Reporting Of Symptomsfor Neoplasm Metastasis. Phase-Based Progress Estimates. ... ARRY-380 Twice Daily Dosagefor Neoplasm Metastasis. Phase-Based Progress Estimates. ...

https://www.withpower.com/trial/phase-1-cancer-advanced-3-2022-e4c53

Neoplasm Metastasis. Neoplasms, Glandular and Epithelial. Neoplastic Processes. Neoplasms. Pathologic Processes. Neoplasms by ... Symptomatic brain metastases or any leptomeningeal metastases that are symptomatic and/or requires treatment. Patients with ... brain metastases are eligible if these have been treated (surgery, radiotherapy). *Penetrating tumour infiltration of major ...

https://www.clinicaltrials.gov/ct2/show/NCT04053283

Metastasis. Series: Ciba Foundation symposium ; 141Material type: Text; Format: print Publication details: Chichester : Wiley, ...

https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7BNeoplasm%20metastasis%7D

Prognostic significance of hyperammonemia in neuroendocrine neoplasm patients with liver metastases. Julie Refardt*, Caroline M ... N2 - Neuroendocrine neoplasms (NENs) are rare, usually slow-growing tumors, often presenting with extensive liver metastases. ... AB - Neuroendocrine neoplasms (NENs) are rare, usually slow-growing tumors, often presenting with extensive liver metastases. ... Neuroendocrine neoplasms (NENs) are rare, usually slow-growing tumors, often presenting with extensive liver metastases. ...

https://pure.eur.nl/en/publications/prognostic-significance-of-hyperammonemia-in-neuroendocrine-neopl

Metastases in the Breast from Nonmammary Malignant Neoplasms Syed A. Hoda The preoperative clinical workup of an apparently ... healthy patient with a breast mass can be cursory and is unlikely to exclude a metastasis from a clinically inapparent (that is ... Metastases from NMMN are rare and account for less than 1% of all mammary malignant neoplasms in clinical series, and up to 5% ... Hematopoietic and lymphoid neoplasms involving the breast are sometimes listed under the rubric of breast "metastases," but ...

https://basicmedicalkey.com/metastases-in-the-breast-from-nonmammary-malignant-neoplasms-2/

... Ragni, Alberto. ;Nervo, Alice;Papotti, ... Purpose Pituitary metastases (PM) are uncommon findings and are mainly derived from breast and lung cancers. No extensive ... Purpose Pituitary metastases (PM) are uncommon findings and are mainly derived from breast and lung cancers. No extensive ... Conclusions PM from NENs have clinical features similar to metastases derived from other solid tumours, albeit the involvement ...

https://iris.univr.it/handle/11562/1047678

Lymphadenopathy (reactive, neoplastic, lymphoma, metastasis) * Vascular neoplasms and malformations * Capillary hemangioma * ...

https://www.medscape.com/answers/1110351-93967/which-conditions-should-be-included-in-the-differential-diagnosis-of-branchial-cleft-cyst

The metastasis rate is low in cases of a tumor diameter < 1 cm or depth of invasion lower than the submucosa; therefore, the ... Metachronous liver metastases may occur after long interval following endoscopic resection; thus, long-term follow-up is ... Here, we report three cases of metachronous liver metastasis after long-term follow-up of endoscopic mucosal resection (EMR) ... All three cases showed metachronous multiple liver metastases after 9-13 years of follow-up for EMR, despite achieving complete ...

https://surgicalcasereports.springeropen.com/articles/10.1186/s40792-020-0792-5/tables/1

A malignant neoplasm (abnormal growth) located on the ovaries. ... A malignant neoplasm (abnormal growth) located on the ovaries. ...

https://medlineplus.gov/ency/imagepages/9627.htm

... and therefore presumably suppress the early phases of metastasis. Here, we determined that exposure of human colorectal cancer ... Colorectal Neoplasms / genetics* * Colorectal Neoplasms / metabolism* * Colorectal Neoplasms / pathology * Disease Models, ... and metastasis of CRC cell lines and was associated with nodal and distant metastasis in CRC patient samples. p53 activation in ... IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis J Clin Invest. 2014 Apr;124(4 ...

https://pubmed.ncbi.nlm.nih.gov/24642471/?dopt=Abstract

Solid pseudopapillary neoplasm of the ovary with metastases to the omentum and regional lymph nodes. Indian Journal of ... Solid pseudopapillary neoplasm of the ovary with metastases to the omentum and regional lymph nodes. ... We report an unusual case of SPN of right ovary with extraovarian spread and metastases to lymph nodes. To the best of our ... It is considered to be a malignant neoplasm with low‑grade biology. Ovarian SPNs are uncommon, have benign morphology, usually ...

https://imsear.searo.who.int/handle/123456789/179571

Neoplasm Metastasis. Neoplasms, Second Primary. Liver Neoplasms. Neoplastic Processes. Neoplasms. Pathologic Processes. ... Digestive System Neoplasms. Neoplasms by Site. Digestive System Diseases. Liver Diseases. Gemcitabine. Oxaliplatin. Mitomycins ... Intrahepatic Chemotherapy to Patients With Non-resectable Liver Metastases From Solid Tumor. The safety and scientific validity ... Intrahepatic and Systemic Chemotherapy Together With Antibody to Patients With Non-resectable Liver Metastases From Solid ...

https://clinicaltrials.gov/ct2/show/study/NCT01511146?term=NCT01511146&rank=1&view=record

Malignancies such as bronchogenic carcinoma, metastasis, lymphoma. *Benign neoplasms such as hamartoma and adenoma ... Benign neoplasms such as hamartoma or adenoma. *Vascular lesion such as a arteriovenous malformation, pulmonary infarction or ...

https://www.atsdr.cdc.gov/csem/asbestos/clinical_assessment.html

View mouse Tiam1 Chr16:89583999-89940657 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

http://www.informatics.jax.org/marker/MGI:103306

This Malignant Neoplasm and Metastatic Osteosarcoma study at UC Cancer is now recruiting people ages up to 50 years. ... Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma a study on Malignant Neoplasm ... Metastatic Malignant Neoplasm in the Lung, Metastatic Osteosarcoma, Osteosarcoma, Neoplasms, Thoracoscopy, Thoracotomy ... Patients must have =, 4 nodules per lung consistent with or suspicious for metastases, with at least one of which being ,= 3 mm ...

https://clinicaltrials.uccancer.org/trial/NCT05235165

Care guide for Bone Metastasis (Discharge Care). Includes: possible causes, signs and symptoms, standard treatment options and ... Learn more about Bone Metastasis. Treatment options. *Medications for Neoplasm of Bone ... Manage a bone metastasis:. *Prevent falls. Wear shoes that fit well and have soles that grip. Wear shoes both inside and ... Bone metastasis often happens in the spine, upper arm or leg bone, ribs, hips, or skull. Cancer that spreads to a bone can ...

https://www.drugs.com/cg/bone-metastasis-discharge-care.html

Neoplasm Metastasis. *Neoplasms, Hormone-Dependent. *Ovarian Neoplasms. *Pelvic Neoplasms. *Uterine Neoplasms. *Endometrial ...

https://medicine.yale.edu/obgyn/drs/faculty/

Categories: Neoplasm Metastasis Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted ...

https://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Neoplasm+Metastasis&parentid=17772&catid=17735

Detection of distant metastases to the mediastinum, liver, lung, bone, and brain is also possible via CT scanning or MRI. ... Oncocytic adrenocortical neoplasms--a clinicopathologic study of 13 new cases emphasizing the importance of their recognition. ... Obtain serum calcium levels to rule out medullary thyroid carcinoma or parathyroid neoplasms. Imaging studies are used to ... Positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) can visualize primary tumors, lymph node metastases, ...

https://emedicine.medscape.com/article/283165-workup

... the pathogenesis of breast cancer metastasis, and breast stromal neoplasms. ... Benign and Low-Grade Fibroepithelial Neoplasms of the Breast have Low Recurrence Rate after Positive Surgical Margins. Mod ... Breast tumor microenvironment and immunotherapy; pathogenesis of breast cancer metastasis; breast stromal and spindle cell ... Cimino-Mathewss ongoing research interests include breast cancer immunotherapy, the pathogenesis of breast cancer metastasis, ...

https://www.hopkinsmedicine.org/profiles/details/ashley-cimino-mathews

primary with liver metastasis. 2. Between 18-75 years old. 3. Patients who will receive TAI using cisplatin or oxaliplatin. 4. ... Neoplasm Metastasis. *Vomiting. .map{width:100%;height:300px;margin-bottom:15px;} Name. Location. ...

http://www.knowcancer.com/cancer-trials/NCT00430313/

Neoplasm Metastasis. 1. 2020. 5161. 0.350. Why? Nuclear Receptor Subfamily 4, Group A, Member 1. 2. 2021. 73. 0.270. Why? ...

https://connects.catalyst.harvard.edu/Profiles/display/person/163627/network/researchareas/details

associated with Neoplasm Metastasis; protein:increased expression:lung, lymph node (human). DNA:CNV, amplification:exon (human) ...

https://rgd.mcw.edu/rgdweb/ontology/annot.html?species=Rat&acc_id=DOID:5409

Pathological tumor-node-metastasis (pTNM) staging for papillary and follicular thyroid carcinomas: a retrospective analysis of ... Diagnosis and management of pediatric endocrine neoplasms. Curr Opin Pediatr. 2009 Jun. 21(3):379-85. [QxMD MEDLINE Link]. ... iodine-avid persistent locoregional or nodal disease and also for identified or assumed iodine-avid distant metastases. ...

https://emedicine.medscape.com/article/924550-guidelines

... colorectal neoplasms; humans; leukemia; lungs; lysine; meta-analysis; metastasis; neoplasm cells; rapamycin; securinine; shrubs ... esophageal neoplasms; glutamine; human health; liver neoplasms; neoplasm cells; pH; pancreatic neoplasms; pollution; research; ... antineoplastic activity; antineoplastic agents; biosynthesis; breast neoplasms; colorectal neoplasms; humans; lung neoplasms; ... metastasis; pancreatic neoplasms; research. Abstract:. ... Histone deacetylase 6 (HDAC6) is a promising target for cancer ...

https://pubag.nal.usda.gov/?f%5Bsubject_facet%5D%5B%5D=antineoplastic+agents&f%5Bsubject_term%5D%5B%5D=antineoplastic+activity&f%5Btext_availability_facet%5D%5B%5D=Citation+in+PubAg&per_page=50&sort=relevance

Neoplasms -- genetics. *Drosophila, cancer, invasion, metastasis, screen, RNAi, lgl, tumour suppressor, invasion suppressor ... Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding ... R Medicine::RC Internal medicine::RC 254 Neoplasms. Tumors. Oncology (including Cancer) ...

https://unow.nottingham.ac.uk/handle/internal/6462

Neoplasm Metastasis. dc.subject. Estrogen Antagonists. dc.subject. Estrogen Receptor alpha. dc.subject. Antineoplastic Agents, ...

https://www.repository.cam.ac.uk/handle/1810/285383?show=full

Dive into the research topics of Expression of the C-C chemokine receptor 7 mediates metastasis of breast cancer to the Lymph ... Expression of the C-C chemokine receptor 7 mediates metastasis of breast cancer to the Lymph nodes in mice. ...

https://www.scholars.northwestern.edu/en/publications/expression-of-the-c-c-chemokine-receptor-7-mediates-metastasis-of/fingerprints/

Members of the miR-34 family are induced by the tumor suppressor p53 and are known to inhibit epithelial-to-mesenchymal transition (EMT) and therefore presumably suppress the early phases of metastasis. (nih.gov)
Dr. Cimino-Mathews's research focuses on the breast cancer tumor microenvironment and immunotherapy, the pathogenesis of breast cancer metastasis, and breast stromal neoplasms. (hopkinsmedicine.org)
Moreover, we have examined the efficacy of D2O-based pharmacological intervention in murine models of human melanoma tumor growth and metastasis. (cdc.gov)
KDR and flt1 mRNA were limited to tumor endothelial cells and were more strongly expressed in the hepatic metastases than in the sinusoidal endothelium of the surrounding liver parenchyma. (jci.org)
VEGF monoclonal antibody administration in tumor-bearing athymic mice led to a dose- and time-dependent inhibition of growth of subcutaneous xenografts and to a marked reduction in the number and size of experimental liver metastases. (jci.org)
Primary carcinoid tumor of the skin (PCTS) is an uncommon indolent neoplasm, with 10 cases described in the literature. (elsevier.com)
Choroid plexus neoplasms can produce hydrocephalus and increased intracranial pressure by a number of mechanisms, including obstruction of normal cerebrospinal fluid (CSF) flow, overproduction of CSF by the tumor itself, local expansion of the ventricles, or spontaneous hemorrhage. (medscape.com)
Secondary neoplasm refers to any of a class of cancerous tumor that is either a metastatic offshoot of a primary tumor, or an apparently unrelated tumor that increases in frequency following certain cancer treatments such as chemotherapy or radiotherapy . (wikipedia.org)
In modern English, tumor is used as a synonym for neoplasm (a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears enlarged in size. (wikipedia.org)
[12] [13] Some neoplasms do not form a tumor - these include leukemia and most forms of carcinoma in situ . (wikipedia.org)

Neuroendocrine neoplasms (NENs) are rare, usually slow-growing tumors, often presenting with extensive liver metastases. (eur.nl)
Usually, there have already been metastases at other sites, or the tumors are detected at various sites synchronously ( 2 , 3 ). (basicmedicalkey.com)
Metastasis from the contralateral breast is a diagnostic consideration when there is bilateral involvement (or history thereof), the histologic appearances of the tumors in the breasts are similar, and there is no evidence of in situ carcinoma in the contralateral breast. (basicmedicalkey.com)
Extrapancreatic solid pseudopapillary neoplasms (SPNs) are rare tumors, which bear morphological, immunohistochemical, and molecular features similar to those of pancreatic counterparts. (who.int)
Positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) can visualize primary tumors, lymph node metastases, lung metastases, and other distant metastases. (medscape.com)
Abundant message for VEGF was found in all tumors, localized to the malignant cells within each neoplasm. (jci.org)
Macrophage influx is associated with negative outcomes for women with breast cancer and has been demonstrated to be required for metastasis of mammary tumors in mouse models. (nih.gov)
PCTS typically follows a benign clinical course and therefore has to be distinguished from cutaneous metastases of visceral carcinoid tumors, which herald dissemination of malignancy and poor prognosis. (elsevier.com)
Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) tumors derived from choroid plexus epithelium that are seen predominantly in children. (medscape.com)
[ 2 , 3 ] In adults, they account for less than 1% of primary intracranial neoplasms, whereas choroid plexus tumors represent up to 5% of pediatric brain tumors, and up to 20% of those arising in children aged 1 year and younger. (medscape.com)
Subsequent radiotherapy in case of incompletely resected tumors can be an important option to avoid recurrence or metastasis even though this occurs rarely. (hindawi.com)
Methods: The American Society for Radiation Oncology convened a task force to address 4 key questions focused on the radiotherapeutic management of intact and resected brain metastases from nonhematologic solid tumors. (elsevier.com)
it represents 4% of malignant skin tumors and is responsible for 80% of deaths from this type of neoplasm. (bvsalud.org)
It represents 4% of treatment with Temozolomide in patients with all malignant skin tumors, responsible for 80% of deaths metastatic MM using the RECIST criteria, in addition to from this type of neoplasm. (bvsalud.org)

Calcific deposits are uncommon in metastases from NMMN but may occur in metastatic mullerian (tubal, ovarian, or peritoneal) carcinomas ( 4 , 5 ). (basicmedicalkey.com)
Nonetheless, primary melanocytic lesions of the breast are exceedingly less common than metastatic melanocytic neoplasms. (basicmedicalkey.com)
Rarely there can be a metastatic neoplasm with no known site of the primary cancer and this is classed as a cancer of unknown primary origin . (wikipedia.org)
However, if these superior lymph nodes are clogged by a metastatic carcinoma, flow of lymph into the paratracheal lymph nodes may take place in the form of the so-called paradoxical metastasis [1,2]. (who.int)
The incidence of metastatic involvement of the PTNs in patients with hypopharyngeal carcinoma, as well as the clinicopathological factors associated with their metastases are not adequately documented. (who.int)
Malignant melanoma (MM) is a malignant neoplasm glioblastoma and a decade for the treatment of that affects the meninges, mucous membranes, and (4) metastatic melanoma , at doses of 200 mg/m2 per day, (5) eyes. (bvsalud.org)

If hematopoietic and lymphoid neoplasms are excluded, the most common NMMNs that secondarily involve the breast include carcinomas of the lung, ovary, stomach, kidney, and cutaneous melanoma. (basicmedicalkey.com)
Deuterium oxide (D2O) induces early stress response gene expression and impairs growth and metastasis of experimental malignant melanoma. (cdc.gov)
Feasibility of D2O-based chemotherapeutic intervention (drinking water (30% w/w)) was demonstrated in a severe combined immunodeficiency (SCID) mouse melanoma metastasis model using luciferase-expressing A375-Luc2 cells. (cdc.gov)
These data demonstrate for the first time that systemic D2O administration impairs growth and metastasis of malignant melanoma through the pharmacological induction of deuterium (2H)-stress. (cdc.gov)
Correct identification of this uncommon AFX variant is essential in order to avoid its misdiagnosis as an aggressive neoplasm such as melanoma. (anncaserep.com)

To compare patterns of recurrence (ipsilateral and/or contralateral) in patients who undergo open or thoracoscopic resection for unilateral or bilateral pulmonary metastases . (uccancer.org)
Cowan M, Argani P, Cimino-Mathews A . Benign and Low-Grade Fibroepithelial Neoplasms of the Breast have Low Recurrence Rate after Positive Surgical Margins. (hopkinsmedicine.org)

Metastases from NMMN are rare and account for less than 1% of all mammary malignant neoplasms in clinical series, and up to 5% of autopsies of patients who die as a result of NMMN ( 1 ). (basicmedicalkey.com)
benign neoplasms , in situ neoplasms , malignant neoplasms , and neoplasms of uncertain or unknown behavior. (wikipedia.org)
[7] Malignant neoplasms are also simply known as cancers and are the focus of oncology . (wikipedia.org)
Potentially-malignant neoplasms include carcinoma in situ . (wikipedia.org)
Malignant neoplasms are commonly called cancer. (wikipedia.org)
Background/purpose: Laparoscopic liver surgery is attracting wider interest for the treatment of benign and malignant neoplasms. (elsevier.com)

To investigate the relationship between angiogenesis and hepatic tumorigenesis, we examined the expression of vascular endothelial growth factor (VEGF) in 8 human colon carcinoma cell lines and in 30 human colorectal cancer liver metastases. (jci.org)
These data indicate that VEGF is a commonly expressed angiogenic factor in human colorectal cancer metastases, that VEGF receptors are up-regulated as a concomitant of hepatic tumorigenesis, and that modulation of VEGF gene expression or activity may represent a potentially effective antineoplastic therapy in colorectal cancer. (jci.org)

The spine is the most frequent area of bone metastasis in patients with systemic neoplastic disease. (bvsalud.org)
Used with neoplasms to indicate the secondary location to which the neoplastic process has metastasized. (bvsalud.org)

All patients had liver metastases with 30% (n = 13) showing signs of portal hypertension. (eur.nl)
In conclusion, hyperammonemia comprises a relevant and potentially underdiagnosed complication of NEN liver metastases and is associated with worse outcomes. (eur.nl)
The purpose of this study is to see if treatment with intrahepatic chemotherapy is a good options in patients with liver metastases. (clinicaltrials.gov)
Detection of distant metastases to the mediastinum, liver, lung, bone, and brain is also possible via CT scanning or MRI. (medscape.com)
The liver tumour was found to be a very large metastasis of pleomorphic adenoma with unharmed resection margins. (minervamedica.it)
Fabbri N, Reale D, Ferrocci G, Ghisellini E, Pansini G. A late solitary liver metastasis from pleomorphic salivary adenoma. (minervamedica.it)
Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. (jci.org)
Even if at initial stages a tumour does not seem aggressive, its central location in proximity with several other organs makes it very dangerous: the most common metastases are in the lymph nodes and in the lungs (55%), liver and bones (33%), followed by the other kidney, the brain, the spleen, the colon and the skin. (lugnani.com)
The first patient was a 61-year-old woman with colorectal carcinoma and liver metastasis, who underwent chemotherapy consisting of 6 cycles of oxaliplatin (the FOLFOX scheme, a chemotherapy regimen consisting of fluorouracil [5 FU], folinic acid, and oxaliplatin). (cdc.gov)
In September 2003, a left colectomy, resection of metastasis in the left side of the liver, and a ligation of the right portal vein were performed. (cdc.gov)
As with all types aims to regroup all the available information on GC of cancer, GC presents at specific metastasis sites, with in this region, discuss the clinicopathological and liver, peritoneal surface and distant lymph nodes being epidemiological factors and compare them with data the most frequent ( 2,5 ). (who.int)

Efficacy of 68Ga PSMA PET / CT in the diagnosis of lymph node metastasis in patients with prostate cancer: a single center prospective randomized controlled trial. (centerwatch.com)
The mean overall survival time was 63.2 +/- 7.7 months and survival time was shorter for younger patients with palliative resection, lymph node metastasis and peritoneal nodules. (who.int)

Bone metastasis is cancer that starts in one area and then spreads to a bone. (drugs.com)
Dr. Cimino-Mathews's ongoing research interests include breast cancer immunotherapy, the pathogenesis of breast cancer metastasis, and breast stromal neoplasms. (hopkinsmedicine.org)
Compare the survival and progression-free survival of patients with hormone-refractory stage IV prostate cancer and bone metastases treated with docetaxel and prednisone combined with either atrasentan vs placebo. (knowcancer.com)
Metastasis is the leading cause of death for cancer patients. (nottingham.ac.uk)
BACKGROUND: In Alpharadin in Symptomatic Prostate Cancer (ALSYMPCA) trial, radium-223 versus placebo prolonged overall survival with favorable safety in castration-resistant prostate cancer patients with symptomatic bone metastases. (qub.ac.uk)
Hacking C, Pelvic metastases from breast cancer. (radiopaedia.org)
Background: Breast cancer bone metastasis is a complication that significantly compromises patient survival due, in part, to the lack of disease-specific biomarkers that allow early and accurate diagnosis. (elsevier.com)
Methods: Using mass spectrometry protein profiling, plasma samples were screened from three independent breast cancer patient cohorts with and without clinical evidence of bone metastasis. (elsevier.com)
Conclusions: These data show that PTHrP(12-48) circulates in plasma of patient with breast cancer and is a novel and predictive biomarker of breast cancer bone metastasis. (elsevier.com)
Importantly, the clinical measurement of PTHrP(12-48) in combination with NTx improves the detection of breast cancer bone metastasis. (elsevier.com)
Impact: In summary, we present the first validated, plasma biomarker signature for diagnosis of breast cancer bone metastasis that may improve the early diagnosis of high-risk individuals. (elsevier.com)
Stereotactic radiosurgery for the treatment of brain metastases is commonly delivered without regard to primary cancer histology. (oldcitypublishing.com)
A neoplasm can be benign , potentially malignant, or malignant ( cancer ). (wikipedia.org)
Peritoneal metastasis is the most common pathway for the spread of ovarian cancer and one of the major causes of cancer death. (jcancer.org)
This provides us a novel strategy for the treatment of ovarian cancer peritoneal metastasis and may help improve the overall survival of ovarian cancer patients. (jcancer.org)
Results: There were 161 eligible breast cancer patients who were treated with PRT secondary to painful bone metastases between 1st January 2005 and 31st December 2009. (bvsalud.org)
A favorable Memorial Sloan-Kettering Cancer Center risk score and absent symptoms related to metastasis are associated with longer survival in these patients. (elsevier.com)
EUS has an integral role in the diagnosis of pancreatic cancer given its high sensitivity for detecting pancreatic neoplasms and the access it affords to perform fine needle aspiration (FNA) of the suspected lesions. (abdominalkey.com)
Similar results were seen in another trial by Tian and co-workers, in which they found that helical CT had the highest accuracy in detecting vascular invasion of pancreatic cancer, and EUS had the highest accuracy of assessing lymph node metastases. (abdominalkey.com)
Matrix metalloproteinases (MMPs) are key enzymes involved in cancer invasion and metastasis. (elsevier.com)
Local therapies, such as radiation therapy for breast cancer, do not increase the incidence of brain metastases. (medscape.com)
terms "stomach neoplasm" and keywords "gastric" and The epidemiological features of GC have been "cancer" were used in combination with MeSH terms and widely studied in Western countries, making them well keywords related to the Arab World: "Lebanon", "Tunisia", understood ( 12,13 ). (who.int)
Adjunctive chemotherapy with bisphosphonates has been reported to delay bone metastasis and improve overall survival in breast cancer. (elsevier.com)

Purpose Pituitary metastases (PM) are uncommon findings and are mainly derived from breast and lung cancers. (univr.it)
This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). (uccancer.org)
Chest radiography may be used to determine the presence of lung metastases. (medscape.com)
Shunt-related metastases have been reported at abdominal sites, with extracranial metastases to the lung and bone reported in rare cases. (medscape.com)

An active IL-6R/STAT3/miR-34a loop was necessary for EMT, invasion, and metastasis of CRC cell lines and was associated with nodal and distant metastasis in CRC patient samples. (nih.gov)

Som [4] emphasized the importance of removing these nodes when attempting radical resection of pharyngo-oesophageal neoplasms and advocated dissection of the lymph nodes lying above the innominate vein in the superior mediastinum. (who.int)

Imaging studies are used to assess local spread and distant metastasis. (medscape.com)
Occasionally, distant metastasis can be seen by EUS and, in this case, the lesion is an M1 lesion, which is also inoperable. (abdominalkey.com)

The preoperative clinical workup of an apparently healthy patient with a breast mass can be cursory and is unlikely to exclude a metastasis from a clinically inapparent (that is, "occult") nonmammary malignant neoplasm (NMMN). (basicmedicalkey.com)
Thus, when faced with a mammary neoplasm that has unusual clinical, radiologic, or histologic features, it is important to consider metastasis in the differential diagnosis. (basicmedicalkey.com)
Clinical and Experimental Metastasis. (umn.edu)
Conclusions: The task force has proposed recommendations to inform best clinical practices on the use of radiation therapy for brain metastases with strong emphasis on multidisciplinary care. (elsevier.com)
Clinical features were reviewed for metastases, disease status, treatment, and any other pre-existing conditions. (anncaserep.com)

In stereotactic radiotherapy (SRT) of 27-30 Gy in three fractions for patients with one to five brain metastases with less than 3.0 cm diameter, daily irradiation is used in the standard arm while irradiation at two- to three-day intervals is performed in the experimental arm. (who.int)

Pleomorphic adenoma (also known as mixed tumour) is the most common neoplasm of the salivary glands. (minervamedica.it)

Unfortunately, one of the consequences of longer survival is the increased risk for the development of brain metastases . (medscape.com)
The neoplasm is highly chemosensitive and radiosensitive, and 5-year survival rates greater than 75% are not uncommon. (medscape.com)

For lymphoid neoplasms, e.g. lymphoma and leukemia , clonality is proven by the amplification of a single rearrangement of their immunoglobulin gene (for B cell lesions) or T cell receptor gene (for T cell lesions). (wikipedia.org)

The overall annual incidence of choroid plexus neoplasms for all ages is 0.3 cases per million. (medscape.com)
There was a statistically significant increase in the incidence of positive paratracheal lymph nodes with thyroid gland invasion, vocal cord invasion, metastasis to the internal jugular chain of the deep cervical nodes and extracapsular and perineural spread. (who.int)
Interestingly, the incidence of pancreatic endocrine neoplasms increased over the same time periods by 106% in men and 125% in women. (abdominalkey.com)

OBJECTIVE The internal high-dose volume varies widely for a given prescribed dose during stereotactic radiosurgery (SRS) to treat brain metastases (BMs). (elsevier.com)
Purpose: This guideline provides updated evidence-based recommendations addressing recent developments in the management of patients with brain metastases, including advanced radiation therapy techniques such as stereotactic radiosurgery (SRS) and hippocampal avoidance whole brain radiation therapy and the emergence of systemic therapies with central nervous system activity. (elsevier.com)

In this study, we examined the MGMT and GLUT2 status in gastrointestinal neuroendocrine neoplasm (NEN). (biomedcentral.com)

Hematopoietic and lymphoid neoplasms involving the breast are sometimes listed under the rubric of breast "metastases," but they are best regarded as either primary breast neoplasms or as a manifestation of a systemic condition, depending upon the extent of organ involvement. (basicmedicalkey.com)
For patients with asymptomatic brain metastases eligible for central nervous system-active systemic therapy, multidisciplinary and patient-centered decision-making to determine whether local therapy may be safely deferred is conditionally recommended. (elsevier.com)
Medical evaluation confirmed the absence of systemic disorders or distant metastases. (bvsalud.org)

Metastases have been described in the ipsilateral axillary lymph nodes in a substantial proportion of patients with metastases in the breast ( 2 ). (basicmedicalkey.com)
Patients are stratified according to disease progression (measurable or non-measurable disease progression vs prostate-specific antigen progression only), use of bisphosphonates at study entry (yes vs no), worst pain, measured by the Brief Pain Inventory "pain" scale ( vs ≥ grade 4), and extraskeletal metastases (yes vs no). (knowcancer.com)
A total of 83 patients with 200 brain metastases were examined retrospectively for predictors of infield failure. (oldcitypublishing.com)
Diabetes mellitus and the risk of progression or malignancy of pancreatic cystic neoplasms in patients undergoing surveillance: A systematic review and meta-analysis. (amedeo.com)
Results: Strong recommendations are made for SRS for patients with limited brain metastases and Eastern Cooperative Oncology Group performance status 0 to 2. (elsevier.com)
For patients with symptomatic brain metastases, upfront local therapy is strongly recommended. (elsevier.com)
For patients with resected brain metastases, SRS is strongly recommended to improve local control. (elsevier.com)
For patients with favorable prognosis and brain metastases receiving whole brain radiation therapy, hippocampal avoidance and memantine are strongly recommended. (elsevier.com)
Temozolomide as monotherapy is a treatment that presents low rates of complete response and partial response, showing better results in patients with lymph node metastases. (bvsalud.org)

The terms 'neoplasm' and 'tumour' are used interchangeably. (who.int)

Generally, within an individual patient the primary and metastases appeared to share a DNA fingerprint pattern with minor variations occurring in different sites suggesting that different populations have derived from a common stem line. (edu.au)

the induction of benign neoplasms may in some circumstances (see Section 9) contribute to the judgement that the exposure is carcinogenic. (who.int)

15, 228S and 216S to investigate the nature of somatic changes and frequency with which clonal changes could be demonstrated during metastasis and progression. (edu.au)

Results A 59-year old female patient, previously submitted to duodeno-cephalo-pancreasectomy for a well-differentiated pancreatic NEN, with known hepatic metastases, underwent a (68) Ga-DOTATOC PET/CT that revealed an uptake in the pituitary gland. (univr.it)
In hepatic metastases of VEGF antibody-treated mice, neither blood vessels nor expression of the mouse KDR homologue flk-1 could be demonstrated. (jci.org)

This study sought to determine if the primary site of origin for brain metastases affected the propensity for local failure. (oldcitypublishing.com)
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. (bvsalud.org)
The present study aimed to evaluate the clinicopathological characteristics of primary hypopharyngeal carcinoma and neck secondaries, which are associated with PTN metastases. (who.int)

In approximately one-third of the cases, the metastasis in the breast is the first presentation of the NMMN. (basicmedicalkey.com)
Radiologic techniques such as MRI (magnetic resonance imaging) and FDG-PET/CT (fluorodeoxyglucose-positron emission tomography-computed tomography) have also detected metastases in the breast from carcinoma of the thyroid ( 7 ), ovary ( 8 ), and soft tissue liposarcoma ( 9 ). (basicmedicalkey.com)

Chronological improvement of pancreatectomy for resectable but advanced pancreatic neuroendocrine neoplasms. (amedeo.com)

Anatomy7

Organisms4

Diseases150

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment56

Phenomena and Processes18

Disciplines and Occupations1

Information Science2

Health Care12

Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis. (1/13013)

Control of metastasis by Asn-linked, beta1-6 branched oligosaccharides in mouse mammary cancer cells. (2/13013)

Role of thrombin receptor in breast cancer invasiveness. (3/13013)

Development of a sensitive, specific reverse transcriptase polymerase chain reaction-based assay for epithelial tumour cells in effusions. (4/13013)

Expression of tissue factor in non-small-cell lung cancers and its relationship to metastasis. (5/13013)

Peritoneal cytology in the surgical evaluation of gastric carcinoma. (6/13013)

Expression of pyrimidine nucleoside phosphorylase mRNA plays an important role in the prognosis of patients with oesophageal cancer. (7/13013)

Phase I study of escalating doses of edatrexate in combination with paclitaxel in patients with metastatic breast cancer. (8/13013)

Neoplasm Metastasis

Lymphatic Metastasis

Lung Neoplasms

Liver Neoplasms

Pancreatic Neoplasms

Neoplasm Invasiveness

Neoplasms

Skin Neoplasms

Breast Neoplasms

Cell Line, Tumor

Neoplasm Staging

Immunohistochemistry

Adenocarcinoma

Kidney Neoplasms

Melanoma

Prognosis

Colorectal Neoplasms

Tumor Markers, Biological

Neoplasm Transplantation

Thyroid Neoplasms

Neoplasms, Cystic, Mucinous, and Serous

Neoplasms, Multiple Primary

Gene Expression Regulation, Neoplastic

Carcinoma

Mice, Nude

Neoplasm Recurrence, Local

Retrospective Studies

Stomach Neoplasms

Brain Neoplasms

Spinal Neoplasms

Colonic Neoplasms

Neoplasm Proteins

Tomography, X-Ray Computed

Neoplasms, Experimental

Lymph Nodes

Prostatic Neoplasms

Carcinoma, Papillary

Cell Movement

Adenocarcinoma, Mucinous

Neoplasms, Second Primary

Ovarian Neoplasms

Splenic Neoplasms

Fatal Outcome

DNA, Neoplasm

Disease Progression

Treatment Outcome

Gastrointestinal Neoplasms

Soft Tissue Neoplasms

Survival Rate

Melanoma, Experimental

Neovascularization, Pathologic

Eye Neoplasms

Carcinoma, Squamous Cell

Mammary Neoplasms, Experimental

Parotid Neoplasms

Muscle Neoplasms

Survival Analysis

Heart Neoplasms

Carcinoma, Pancreatic Ductal

Adenocarcinoma, Papillary

Tumor Cells, Cultured

Antineoplastic Agents

Antigens, Neoplasm

Combined Modality Therapy

Peritoneal Neoplasms

Meningeal Neoplasms

Bone Marrow Neoplasms

Transplantation, Heterologous

Abdominal Neoplasms

Myeloproliferative Disorders

Appendiceal Neoplasms

Osteosarcoma

Lymph Node Excision

Endocrine Gland Neoplasms

Cell Proliferation

Neoplasm Seeding

Hepatectomy

Testicular Neoplasms

Intestinal Neoplasms

Skull Neoplasms