Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Neoplasms
Cell Movement
Neoplasms, Cystic, Mucinous, and Serous
Neoplasm Metastasis
Gene Expression Regulation, Neoplastic
Matrix Metalloproteinase 2
Immunohistochemistry
Matrix Metalloproteinase 9
Neoplasms, Multiple Primary
Tumor Cells, Cultured
Neoplasms, Second Primary
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Ovarian Neoplasms
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Carcinoma, Pancreatic Ductal
Mice, Nude
Cadherins
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Neoplasms, Experimental
Neoplasm Transplantation
Adenocarcinoma, Mucinous
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Myeloproliferative Disorders
Laminin
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Gastrointestinal Neoplasms
Cystadenoma
Neoplasm Staging
Neoplasms, Connective and Soft Tissue
Neoplasms, Plasma Cell
Reverse Transcriptase Polymerase Chain Reaction
Carcinoma, Papillary
Cell Transformation, Neoplastic
Carcinoma
Drug Combinations
RNA, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Cystadenoma, Mucinous
Blotting, Western
Urokinase-Type Plasminogen Activator
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Transfection
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Neoplasms, Vascular Tissue
Antigens, Neoplasm
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Colorectal Neoplasms
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Trophoblasts
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
Neoplasms, Radiation-Induced
Adenocarcinoma, Papillary
Testicular Neoplasms
Neoplasms, Muscle Tissue
Neoplasms, Glandular and Epithelial
Disease Progression
Collagen
Cystadenocarcinoma, Mucinous
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
Antigens, CD82
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Receptors, Urokinase Plasminogen Activator
Up-Regulation
Carcinoma, Squamous Cell
Soft Tissue Neoplasms
Hematologic Neoplasms
Dog Diseases
Neoplasms, Adnexal and Skin Appendage
Matrix Metalloproteinases
Epithelial-Mesenchymal Transition
Matrix Metalloproteinase Inhibitors
Vascular Neoplasms
Cell Division
Prognosis
Palatal Neoplasms
Down-Regulation
RNA Interference
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Cystadenocarcinoma
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Heart Neoplasms
Cystadenoma, Serous
A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)
Neovascularization, Pathologic
Neoplasm Recurrence, Local
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Phenotype
Matrix Metalloproteinase 14
A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.
Neoplasms, Germ Cell and Embryonal
Bone Marrow Neoplasms
Virulence
Vimentin
Astrocytoma
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Hepatocyte Growth Factor
Neoplasms, Adipose Tissue
Head and Neck Neoplasms
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
S100 Proteins
A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
Meningeal Neoplasms
Mice, SCID
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Introduced Species
Pituitary Neoplasms
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Mutation
Gene Expression Profiling
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Immunoenzyme Techniques
Tomography, X-Ray Computed
Proto-Oncogene Proteins c-met
Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations of the gene for PROTO-ONCOGENE PROTEINS C-MET are associated with papillary renal carcinoma and other neoplasia.
Tissue Inhibitor of Metalloproteinase-2
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.
Gene Silencing
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Extracellular Matrix
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Carcinoma, Acinar Cell
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Spinal Cord Neoplasms
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Gene Knockdown Techniques
Adenoma, Oxyphilic
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
Nervous System Neoplasms
Neoplasm Grading
Janus Kinase 2
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
Muscle Neoplasms
Hemangiosarcoma
Phosphorylation
Matrix Metalloproteinase 7
Dogs
Myelodysplastic-Myeloproliferative Diseases
Mammary Neoplasms, Experimental
Gelatinases
Peripheral Nervous System Neoplasms
Cerebral Ventricle Neoplasms
Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.
Tissue Inhibitor of Metalloproteinase-1
Pleural Neoplasms
Transcription Factors
Gene Expression
Sarcoma
Fibrosarcoma
Common Bile Duct Neoplasms
Matrix Metalloproteinases, Membrane-Associated
Mesoderm
Lymphatic Metastasis
Jaw Neoplasms
Fibroblasts
Oligonucleotide Array Sequence Analysis
Carcinogens
Transforming Growth Factor beta
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Real-Time Polymerase Chain Reaction
Cerebellar Neoplasms
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
Cells, Cultured
Cell Survival
Immunohistochemical expression of mdm2 and p21WAF1 in invasive cervical cancer: correlation with p53 protein and high risk HPV infection. (1/11529)
AIM: To investigate the immunocytochemical staining pattern of mdm2 and p21WAF1 proteins in invasive cervical cancer and to determine its relation with the expression of p53 and with the high risk HPV infection. METHODS: Immunocytochemistry for p53, mdm2, and p21WAF1 was performed in 31 paraffin embedded sections of invasive cervical cancer. The results were assessed by image analysis, evaluating for each protein the optical density of the immunostained area, scored as percentage of the total nuclear area. The presence of high risk human papillomavirus (HPV) infection was detected by using the polymerase chain reaction. RESULTS: Immunostaining for both mdm2 and p21WAF1 was correlated with p53 expression; however, the correlation between p53 and mdm2 (R = 0.49; p < 0.01) was more significant than between p53 and p21WAF1 (R = 0.31; p < 0.05); the less stringent correlation between p53 and p21WAF1 might reflect the p53 independent mechanisms of p21WAF1 induction. Similar average levels of p53, mdm2, and p21WAF1 immunostaining were found in the presence or absence of high risk HPV-DNA, without significant differences between the two groups. CONCLUSIONS: These data suggest that mdm2 and p21WAF1 proteins are expressed in invasive cervical cancer and that their immunocytochemical staining pattern is not abrogated by the presence of high risk HPV genomic sequences. (+info)The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells. (2/11529)
The acquisition of invasiveness is a crucial step in the malignant progression of cancer. In cancers of the colon and of other organs the E-cadherin/catenin complex, which is implicated in homotypic cell-cell adhesion as well as in signal transduction, serves as a powerful inhibitor of invasion. We show here that one allele of the alphaE-catenin (CTNNA1) gene is mutated in the human colon cancer cell family HCT-8, which is identical to HCT-15, DLD-1 and HRT-18. Genetic instability, due to mutations in the HMSH6 (also called GTBP) mismatch repair gene, results in the spontaneous occurrence of invasive variants, all carrying either a mutation or exon skipping in the second alphaE-catenin allele. The alphaE-catenin gene is therefore, an invasion-suppressor gene in accordance with the two-hit model of Knudsen for tumour-suppressor genes. (+info)Role of thrombin receptor in breast cancer invasiveness. (3/11529)
Invasion, the ability of an epithelial cancer cell to detach from and move through a basement membrane, is a central process in tumour metastasis. Two components of invasion are proteolysis of extracellular matrix and cellular movement through it. A potential promoter of these two processes is thrombin, the serine proteinase derived from the ubiquitous plasma protein prothrombin. Thrombin promotes the invasion of MDA-MB231 breast tumour cells (a highly aggressive cell line) in an in vitro assay. Invasion by MDA-MB436 and MCF-7 cells, less aggressive cell lines, is not promoted by thrombin. Thrombin, added to the cells, is a stimulator of cellular movement; fibroblast-conditioned medium is the chemotaxin. Thrombin-promoted invasion is inhibited by hirudin. Stimulation of invasion is a receptor-mediated process that is mimicked by a thrombin receptor-activating peptide. Thrombin has no effect on chemotaxis in vitro. Thrombin receptor is detectable on the surface of MDA-MB231 cells, but not on the other two cell lines. Introduction of oestrogen receptors into MDA-MB231 cells by transfection with pHEO had no effect on thrombin receptor expression, in the presence or absence of oestradiol. This paper demonstrates that thrombin increases invasion by the aggressive breast cancer cell line MDA-MB231 by a thrombin receptor-dependent mechanism. (+info)Expression of pyrimidine nucleoside phosphorylase mRNA plays an important role in the prognosis of patients with oesophageal cancer. (4/11529)
To clarify the significance of the expression of pyrimidine nucleoside phosphorylase (PyNPase) mRNA as a predictive factor for the prognosis of patients with oesophageal carcinoma, the PyNPase mRNA in the tumours and normal tissues from 55 resected cases of oesophageal carcinoma was examined by a reverse transcription polymerase chain reaction (RT-PCR). As a result, a positive correlation was observed between the tumour/normal (T/N) ratio of the expression of PyNPase mRNA by RT-PCR and that of the enzyme activity of PyNPase based on the findings of an enzyme linked immunosolvent assay (r = 0.594, P = 0.009). The T/N ratio of the expression of PyNPase mRNA was significantly higher in the cases with lymph vessel invasion (P = 0.013), lymph node metastasis (P = 0.0016), and an advanced stage of the disease (P = 0.021) than those without these factors. The patients with a higher T/N ratio of PyNPase mRNA showed significantly worse prognosis than those with a lower T/N ratio (P = 0.023 with log-rank tests). A multivariate analysis for the cumulative survival rates revealed that a high T/N ratio of the expression of PyNPase mRNA was independently related to a poor prognosis. These findings suggested that the determination of PyNPase mRNA by RT-PCR thus appears to be a new useful parameter for identifying both a poor prognosis and a highly malignant potential of oesophageal carcinoma. (+info)Low tumour cell proliferation at the invasive margin is associated with a poor prognosis in Dukes' stage B colorectal cancers. (5/11529)
The conflicting results about the prognostic impact of tumour cell proliferation in colorectal cancer might be explained by the heterogeneity observed within these tumours. We have investigated whether a systematic spatial heterogeneity exists between different compartments, and whether the presence of such a systematic heterogeneity has any impact on survival. Fifty-six Dukes' stage B colorectal cancers were carefully morphometrically quantified with respect to the immunohistochemical expression of the proliferative marker Ki-67 at both the luminal border and the invasive margin. The proliferative activity was significantly higher at the luminal border compared with the invasive margin (P<0.001), although the two compartments were also significantly correlated with each other. Tumours with low proliferation at the invasive margin had a significantly poorer prognosis both in univariate (P = 0.014) and in multivariate survival analyses (P = 0.042). We conclude that Dukes' B colorectal cancers exhibit a systematic spatial heterogeneity with respect to proliferation, and tumours with low proliferation at the invasive margin had a poor prognosis. The present data independently confirm recent results from the authors, and provide new insights into the understanding of tumour cell proliferation in colorectal cancer. (+info)A possible involvement of aberrant expression of the FHIT gene in the carcinogenesis of squamous cell carcinoma of the uterine cervix. (6/11529)
To investigate involvement of an aberrant expression of the FHIT (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by the reverse transcriptase polymerase chain reaction (RT-PCR) and cDNA sequence method in 32 cervical invasive carcinomas (25 squamous cell carcinomas and seven adeno- or adenosquamous carcinomas) and 18 of its precursor lesions [four low-grade and 14 high-grade cervical intraepithelial neoplasias (CINs)]. We also examined a link between the occurrence of the aberrant expression and human papillomavirus (HPV). We detected the aberrant FHIT transcripts in 11 of 25 (44%) cervical invasive squamous cell carcinomas and in 5 of 14 (36%) high-grade CINs (CIN 2 or 3), whereas they were not found in seven non-squamous type and four low-grade CINs (CIN 1). The alteration patterns of the FHIT gene expression in high-grade CINs were virtually similar to those found in invasive carcinomas, such that the exons 5-7 were consistently deleted associated or unassociated with loss of the exon 4 and/or 8. The incidence of the aberrant expression was not related to the presence of HPV and its type. These data indicate that the aberrant expression of the FHIT gene is observed in precursor lesions of cervical carcinoma as well as invasive carcinomas, with its incidence not increasing with advance of clinical stage. Given the squamous cell type dominant expression, the aberrant expression may play a critical role in the generation of squamous cell carcinoma of the uterine cervix, but not the consequence of the progression of the cancer. (+info)Enhanced tumor growth and invasiveness in vivo by a carboxyl-terminal fragment of alpha1-proteinase inhibitor generated by matrix metalloproteinases: a possible modulatory role in natural killer cytotoxicity. (7/11529)
Matrix metalloproteinases (MMPs) are believed to contribute to the complex process of cancer progression. They also exhibit an alpha1-proteinase inhibitor (alphaPI)-degrading activity generating a carboxyl-terminal fragment of approximately 5 kd (alphaPI-C). This study reports that overexpression of alphaPI-C in S2-020, a cloned subline derived from the human pancreas adenocarcinoma cell line SUIT-2, potentiates the growth capability of the cells in nude mice. After stable transfection of a vector containing a chimeric cDNA encoding a signal peptide sequence of tissue inhibitor of metalloproteinase-1 followed by cDNA for alphaPI-C into S2-020 cells, three clones that stably secrete alphaPI-C were obtained. The ectopic expression of alphaPI-C did not alter in vitro cellular growth. However, subcutaneous injection of the alphaPI-C-secreting clones resulted in tumors that were 1.5 to 3-fold larger than those of control clones with an increased tendency to invasiveness and lymph node metastasis. These effects could be a result of modulation of natural killer (NK) cell-mediated control of tumor growth in nude mice, as the growth advantage of alphaPI-C-secreting clones was not observed in NK-depleted mice, and alphaPI-C-secreting clones showed decreased NK sensitivity in vitro. In addition, production of alphaPI and generation of the cleaved form of alphaPI by MMP were observed in various human tumor cell lines and in a highly metastatic subline of SUIT-2 in vitro. These results provide experimental evidence that the alphaPI-degrading activity of MMPs may play a role in tumor progression not only via the inactivation of alphaPI but also via the generation of alphaPI-C. (+info)Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas. (8/11529)
Collagenase-3 (MMP-13) is a human matrix metalloproteinase specifically expressed by invading tumor cells in squamous cell carcinomas (SCCs) of the head and neck. Here, we have further elucidated the role of MMP-13 in tumor invasion by examining its expression in invasive malignant tumors of the female genital tract. Using in situ hybridization, expression of MMP-13 mRNA was detected in 9 of 12 vulvar SCCs, primarily in tumor cells, but not in intact vulvar epithelium, in cervical SCCs (n = 12), or in endometrial (n = 11) or ovarian adenocarcinomas (n = 8). MMP-13 expression was especially abundant in vulvar carcinomas showing metastasis to lymph nodes and was associated with expression of membrane type 1 MMP by tumor cells and gelatinase-A (MMP-2) by stromal cells, as detected by immunohistochemistry. MMP-13 mRNAs were detected in 9 of 11 cell lines established from vulvar carcinomas and in 4 of 6 cell lines from cervical carcinomas, whereas endometrial (n = 10) and ovarian (n = 9) carcinoma cell lines were negative for MMP-13 mRNA. No correlation was detected between MMP-13 expression and p53 gene mutations in vulvar SCC cell lines. However, MMP-13 expression was detected in 5 of 6 vulvar and cervical SCC cell lines harboring HPV 16 or 68 DNA. These results show that MMP-13 is specifically expressed by malignantly transformed squamous epithelial cells, including vulvar SCC cells, and appears to serve as a marker for their invasive capacity. (+info)The proliferation rate of cells was analyzed by MTT assay - MEK Inhibitors in highly invasive breast cancer cells
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OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo. - NDM Research...
The mode and dynamics of glioblastoma cell invasion into a decellularized tissue-derived extracellular matrix-based three...
Suppression of PPARβ, and DHA treatment, inhibit NaV1.5 and NHE-1 pro-invasive activities.
| DIAL.pr - BOREAL
Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
Invasion Signal | Science Signaling
Cell Invasion Assay (Basement Membrane), 24-well, 8 μm Kit-2313 - Creative BioMart
Tumor volume and lymphovascular space invasion as a prognostic factor in early invasive adenocarcinoma of the cervix<...
Leicester Research Archive: Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: Matrix...
Aspirin and P2Y 12 inhibition attenuate platelet-induced ovarian cancer cell invasion | BMC Cancer | Full Text
Prostaglandin E2 promotes hepatocellular carcinoma cell invasion through upregulation of YB-1 protein expression. | Sigma...
Plus it
Plus it
EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1<...
In silico studies on structure prediction and inhibitory action of selected natural compounds on cell invasion protein SipB...
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion | Science Signaling
Role of CRN2 in glioblastoma cell invasion and characterization of CRN2 deficient mice - Kölner UniversitätsPublikationsServer
The Madeleine Oudin Lab | Sackler
Spying on Cancer Cell Invasion [video] | EurekAlert! Science News
Most recent papers with the keyword pancreatic cancer neural invasion | Read by QxMD
Difference between revisions of Hyung-Do Kim - OpenWetWare
Cell Migration or Invasion Assay | BMG LABTECH
corrigendum-Isoorientin induces apoptosis, decreases invasiveness, and | OTT
OGT2115 | OGT-2115 | CAS#853929-59-6 | heparanase inhibitor | MedKoo
Seminar - Pro-invasive tumour-stroma interactions:the key role of cancer associated fibroblasts - The University of Nottingham
Control of lung cancer invasion and metastasis by vimentin
Effect of TGFβ1 on the phenotype, migratory ability, a | Open-i
Cyclic RNA hsa circ 0091017 inhibits proliferation, migration and invasiveness of bladder cancer cells by binding to microRNA...
The decrease chambers were filled with DME medium made up of five% FBS as a chemoattractant | MEK Inhibitor-sgkinhibitor.com
Team:NTU-Taida/Project/Introduction - 2012.igem.org
Team:NTU-Taida/Project/Introduction - 2012.igem.org
Cobot Invasion at Japans CEATEC | EE Times
Ent survival. However, tumor invasion and metastasis contribute to the great | URAT1 inhibitor urat1inhibitor.com
SCAI (suppressor of cancer cell invasion) - KOMP (Knockout Mouse Project)
Automated Kinetic Imaging of Cell Migration and Invasion Assays using Corning FluoroBlok Permeable Supports | October 9, 2014
Automated, Kinetic Imaging of Cell Migration and Invasion Assays using Corning FluoroBlok™ Permeable Supports | October 9, 2014
Save 51% on Invasion: Brain Craving on Steam
Invasion of the Bunny Snatchers: The Return | Looney Tunes Fanon Wiki | Fandom
Cancer - Wiki | Golden
Endoscopic submucosal dissection
The resected size and shape can be controlled, en bloc resection is possible even in a large neoplasm, and neoplasms with ... Either polypectomy or endoscopic mucosal resection (EMR) is beneficial for patients because of its low level of invasiveness. ... So this technique can be applied to the resection of complex neoplasms such as large neoplasms, ulcerative non-lifting ... especially for large or ulcerative neoplasms. Recently, the ESD technique is applied to esophageal or colorectal neoplasms in ...
ZNF238
... resulting in a cellularly diverse neoplasm. This new diversity has been observed to increase the invasiveness of the tumor, ...
List of MeSH codes (C23)
... neoplasm invasiveness MeSH C23.550.727.645.500 - leukemic infiltration MeSH C23.550.727.650 - neoplasm metastasis MeSH C23.550. ... neoplasm seeding MeSH C23.550.727.650.895 - neoplasms, unknown primary MeSH C23.550.727.655 - neoplasm recurrence, local MeSH ... C23.550.727.670 - neoplasm regression, spontaneous MeSH C23.550.727.700 - neoplasm, residual MeSH C23.550.737.500 - retrograde ... 727.650.560 - lymphatic metastasis MeSH C23.550.727.650.645 - neoplasm circulating cells MeSH C23.550.727.650.830 - ...
Brain tumor
Invasion or invasiveness is the spatial expansion of the tumor through uncontrolled mitosis, in the sense that the neoplasm ... Neoplasms will often show as differently colored masses (also referred to as processes) in CT or MRI results.[citation needed] ... More generally a neoplasm may cause release of metabolic end products (e.g., free radicals, altered electrolytes, ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ...
Targeted therapy of lung cancer
Lung cancer is an extremely heterogeneous family of malignant neoplasms, with well over 50 different histological variants ... invasiveness, and metastasis characteristic of malignant tumors. The increased differential activity usually results in fewer ...
Ameloblastoma
The neoplasms are often associated with the presence of unerupted teeth, displacement of adjacent teeth and resorption of roots ... There is also some research suggesting that α5β1 integrin may participate in the local invasiveness of ameloblastomas. People ... Smaller mandibular neoplasms have been enucleated where the cavity of the tumour is curetted, allowing preservation of the bone ... Thus, surgery is the most common treatment of this neoplasm. A case of giant ameloblastoma was recently reported and managed ...
Desmoplasia
... may occur around a neoplasm, causing dense fibrosis around the tumor, or scar tissue (adhesions) within the abdomen ... the cancer cells secrete matrix degrading enzymes to destroy normal tissue ECM thereby promoting growth and invasiveness of the ... Desmoplasia is usually only associated with malignant neoplasms, which can evoke a fibrotic response invading healthy tissue. ... not all scars are associated with malignant neoplasms. Mature scars are usually thick, collagenous bundles arranged ...
Spermatocele
There are a few different treatment options, ranging in levels of invasiveness. Certain drugs such as oral analgesics or anti- ... and neoplasm. The primary care physician may diagnose and manage benign causes of scrotal masses such as hydrocele, varicocele ...
Carcinoma
Lobular and Medullary Neoplasms (8550-8559) Acinar cell neoplasms (8560-8580) Complex epithelial neoplasms The term carcinoma ... local invasiveness); the ability to spread to other sites within the body (metastasize) by penetrating or entering into the ... Adnexal and Skin appendage Neoplasms (8430-8439) Mucoepidermoid Neoplasms (8440-8490) Cystic, Mucinous and Serous Neoplasms ( ... 8010-8045) Epithelial neoplasms, NOS (8050-8080) Squamous cell neoplasms (M8070/3) Squamous cell carcinoma, NOS (8090-8110) ...
Mammary tumor
A mammary tumor is a neoplasm originating in the mammary gland. It is a common finding in older female dogs and cats that are ... Biopsy will give type and invasiveness of the tumor. In addition, newer studies showed that certain gene expression patterns ... Benjamin S, Lee A, Saunders W (1999). "Classification and behavior of canine mammary epithelial neoplasms based on life-span ...
Cathepsin K
... is expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. ... 1 February 2013). "A Broad Survey of Cathepsin K Immunoreactivity in Human Neoplasms". American Journal of Clinical Pathology. ...
Unicameral bone cyst
It is suggested that the presence of these fusion genes indicates that SEC is a true neoplasm. Unicameral bone cysts are found ... depending on the invasiveness of the cyst, it can cause a pathological fracture or even destroy the epiphyseal plate leading to ...
Neuroendocrine tumor
G1 and G2 neuroendocrine neoplasms are called neuroendocrine tumors (NETs) - formerly called carcinoid tumours. G3 neoplasms ... Several issues help define appropriate treatment of a neuroendocrine tumor, including its location, invasiveness, hormone ... Although there are many kinds of NETs, they are treated as a group of tissue because the cells of these neoplasms share common ... Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. They most ...
Acral lentiginous melanoma
Shea, Christopher R.; Reed, Jon A.; Prieto, Victor G. (2014-11-03). Pathology of Challenging Melanocytic Neoplasms: Diagnosis ... This second biopsy will determine the depth and invasiveness of the melanoma, and will help to define what the final treatment ...
Saliva testing
Proponents of saliva testing cite its ease of collection, safety, non-invasiveness, affordability, accuracy, and capacity to ... and neoplasms. The following conditions are among those that can be detected through saliva testing (list not comprehensive): ... benign and metastatic neoplasms (such as breast cancer, pancreatic cancer, and oral cancer), infectious conditions (such as HIV ...
Lymphangioleiomyomatosis
Other neoplasms (or sources of inflammation) should therefore be considered in known or suspected LAM cases in which FDG-PET ... Increased LAM cell migration and invasiveness is rescued by TSC2 re-expression. The cellular and molecular mechanisms of ...
Bladder cancer
... without which muscle invasiveness cannot be determined), then a second TURBT is strongly recommended. Moreover, nearly half of ... neoplasms of the urinary bladder. Bladder Consensus Conference Committee". The American Journal of Surgical Pathology. 22 (12 ... Papillary lesions Urothelial Papilloma Papillary urothelial neoplasm of low malignant potential (PUNLMP) Low Grade High Grade ...
Downregulation and upregulation
Such mutations and epigenetic alterations can give rise to cancer (see malignant neoplasms).[verification needed] Investigation ... "Promoter hypermethylation of tumor suppressor genes correlates with tumor grade and invasiveness in patients with urothelial ...
Primary effusion lymphoma
This lymphoma also belongs to a group of lymphoid neoplasms with plasmablastic differentiation that involve malignant ... binds with P53 to inhibit cell death and interacts with beta-catenin to promote the tissue-invasiveness of cancer cells; and 6 ... List of hematologic conditions Chen BJ, Chuang SS (March 2020). "Lymphoid Neoplasms With Plasmablastic Differentiation: A ... "Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the ...
Fibroblast activation protein, alpha
Aoyama A, Chen WT (November 1990). "A 170-kDa membrane-bound protease is associated with the expression of invasiveness by ... in cervical carcinoma and cervical intraepithelial neoplasm". Anticancer Research. 23 (4): 3195-8. PMID 12926053. Iwasa S, Jin ... "A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells". Cancer ...
Malignancy
... in cancers is characterized by anaplasia, invasiveness, and metastasis. Malignant tumors are also characterized by ... Uses of "malignant" in oncology include: Malignancy, malignant neoplasm and malignant tumor are synonymous with cancer ...
Epithelioid sarcoma
They are also involved in cancer stem cell coordination and disease invasiveness and metastasis. Hhat inhibitors (such as RU- ... a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study ...
Spiradenoma
CT scans, FDG-positron emission tomography, and magnetic resonance imaging to detect 1) the shape and local invasiveness of ... "Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation". ... "Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on ... List of cutaneous conditions Dermal cylindroma Trichoepithelioma CYLD cutaneous syndrome List of cutaneous neoplasms associated ...
CUX1
... signaling that enhances cancer cell motility and invasiveness". Cancer Cell 2005, 7(6):521-32. Ripka S, Neesse A, Riedel J, Bug ... "Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression". Blood 2011, 118:167-76. ... of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms ...
Glioblastoma
... an alternative explanation for increased invasiveness of IDH1 mutant gliomas". Neuro-Oncology. 16 (12): 1669-70. doi:10.1093/ ... "A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option". ...
Undifferentiated pleomorphic sarcoma
... poorly differentiated neoplasm, i.e. an abnormal growth of cells that have an unclear identity and/or cell of origin. WHO ... tumors deemed highly aggressive based on their pathology and/or local invasiveness, inoperable tumors, and resections that did ...
Browsing by Subject "Neoplasm Invasiveness"
Cadre de mise en œuvre de l'initiative mondiale contre le cancer du sein : évaluation, renforcement et amplification des...
Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells
Urethral Cancer Workup: Laboratory Studies, Imaging Studies, Other Tests
HuGE Navigator|Genopedia|PHGKB
Medical Science Monitor | LINC00922 Accelerates the Proliferation, Migration and Invasion of Lung Cancer Via the miRNA-204...
Gynecology and Obstetrics Conferences | Gynecology and Obstetrics 2023| Gynecology and Obstetrics Events | Gynecology and...
Multiple foci of invasive breast cancer: can breast MRI influence surgical management? - Nuffield Department of Orthopaedics,...
Pediatric Astrocytoma: Practice Essentials, Background, Pathophysiology
Astrocytomas comprise a wide range of neoplasms that differ in their extent of invasiveness, morphological features, tendency ... BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel ... These tumors are the principle CNS neoplasm of neurofibromatosis type 1 (NF1). ...
Patient-specific metrics of invasiveness reveal significant prognostic benefit of resection in a predictable subset of gliomas<...
N2 - Object: Malignant gliomas are incurable, primary brain neoplasms noted for their potential to extensively invade brain ... Our goal was to apply a mathematical modeling approach to estimate the overall tumor invasiveness on a patient-by-patient basis ... Our goal was to apply a mathematical modeling approach to estimate the overall tumor invasiveness on a patient-by-patient basis ... Our goal was to apply a mathematical modeling approach to estimate the overall tumor invasiveness on a patient-by-patient basis ...
CT Can Help Avoid Useless Surgery
As seen in this example, neoplasm size, contour, degree of invasiveness and tissue density can be accurately evaluated by ... to provide further information on neoplasm size and/or degree of invasiveness. ... Invasiveness and tissue architecture cannot be assessed.. Ultrasound evaluations of small soft tissue masses occurring along ...
Biblio | Page 5 | Linus Pauling Institute | Oregon State University
Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?
The authors of the concept of neoplasm chemoprevention are L.W. Wattenberg and M.B. Sporn. Their studies made in the 1960s and ... Genistein also proved to inhibit the invasiveness of tumour cells. This effect was due to the inhibition of expression of c- ... The presence of premalignant condition does not imply that a neoplasm will develop for sure; it only results in increased risk ... EGRF overexpression was confirmed in numerous types of neoplasms, also in more than 80% of HNSCC. This resulted in searching ...
MeSH Browser
Neoplasms [C04] * Neoplasms by Histologic Type [C04.557] * Neoplasms, Glandular and Epithelial [C04.557.470] * Neoplasms, ... The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. ... Neoplasms [C04] * Neoplasms by Histologic Type [C04.557] * Neoplasms, Glandular and Epithelial [C04.557.470] * Carcinoma [ ... coordinate with precoordinated organ/neoplasm term. Scope Note. A malignant neoplasm derived from glandular epithelium, in ...
Faculty Publications Archive | Lewis-Sigler Institute
New experimental markers for early detection of high-risk prostate cancer: Role of cell-cell adhesion and cell migration<...
HuGE Navigator|Genopedia|PHGKB
HuGE Navigator|Genopedia|PHGKB
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DeCS
Neoplasm Invasiveness - Preferred Concept UI. M0014576. Scope note. Ability of neoplasms to infiltrate and actively destroy ... Ability of neoplasms to infiltrate and actively destroy surrounding tissue.. Annotation:. IM general only or for invasive ... process; coordinate NIM with specific neoplasm terms / pathol (IM). Allowable Qualifiers:. DG diagnostic imaging. DI diagnosis ... Invasion, Neoplasm. Invasiveness, Neoplasm. Neoplasm Invasion. Tree number(s):. C04.697.645. C23.550.727.645. ...
IMSEAR at SEARO: Clinicopathological features predicting recurrence of intracranial meningiomas.
Role of matrix metalloproteinase 9 in pituitary tumor behavior. - MRC Weatherall Institute of Molecular Medicine
The mechanisms whereby MMP-9 expression influences tumor recurrence and invasiveness, and its association with angiogenesis, ... Adenoma, Carcinoma, Humans, Immunohistochemistry, Matrix Metalloproteinase 9, Neoplasm Invasiveness, Neoplasm Recurrence, Local ... The mechanisms whereby MMP-9 expression influences tumor recurrence and invasiveness, and its association with angiogenesis, ...
Cell adhesion strength and tractions are mechano-diagnostic features of cellular invasiveness [email protected]
Invasiveness; Shear devices; Vinculin, Diseases, actin; vinculin, animal; cell adhesion; metabolism; mouse; neoplasm; NIH 3T3 ... These correlations in adhesion strengths and traction stresses with cell invasiveness may be useful in cancer diagnostics and ... Cell adhesion strength and tractions are mechano-diagnostic features of cellular invasiveness ... Cell adhesion strength and tractions are mechano-diagnostic features of cellular invasiveness. In: Soft Matter, 18 (23). pp. ...
Sperm protein 17 is expressed in human nervous system tumours | BMC Cancer | Full Text
Table 2 Sperm protein 17 expression frequencies in different histological subtypes of primary nervous system neoplasms. The ... invasiveness, tendency to progression and recurrence, and response to treatments [1-4]. Their still highly unfavourable ... Immunohistochemistry of Sp17 in nervous system neoplasms: a-c. glioblastomas; d. astrocytoma; e. meningioma; f. ependimoma. In ... Brain and other nervous system (NS) tumours are a group of neoplasms that vary in terms of their site of origin, morphological ...
MALAT1 promoted invasiveness of gastric adenocarcinoma - Fingerprint
- Yonsei University
sg:pub.10.1007/bf00184243 - Springer Nature SciGraph
"Neoplasm Invasiveness", "type": "DefinedTerm" }, { "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", "name": "Polymorphism, ... ": "Urinary Bladder Neoplasms", "type": "DefinedTerm" } ], "author": [ { "affiliation": { "alternateName": "USC Norris ... ": "DNA, Neoplasm", "type": "DefinedTerm" }, { "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", "name": "ErbB Receptors", " ...
Citations Library | PerkinElmer
Neoplasm Invasiveness; Paxillin/*metabolism; Phosphorylation. ... Neoplasm Transplantation; Organ Size/drug effects; Osteoblasts/ ... MDA-MB-231-luc2-tdtomato, IVIS, tdtomato, fluorescent protein, Animals; Breast Neoplasms/enzymology/*metabolism/*pathology; ... MDA-MB-231-D3H2Ln, IVIS, Bioluminescence, Activins/*metabolism; Animals; Bone Neoplasms/*complications/pathology/ ... Neoplasm Metastasis; Solubility/drug effects; Subcellular Fractions/drug effects/metabolism; Tryptophan/*analogs & derivatives/ ...
CarcinomaRecurrenceBrain neoplasmsNeoplasticTumorsBiologicalGlandularMorphological featuresStagingPancreaticEpithelialAdenomaHistological aspectsApoptosisProliferationMatrigelTumoursDifferExtentSurgicalThymicResectionDiagnosisMetastasisColorectal NeoplasmsColonic neoplasmsSkin NeoplasmsMelanomaSquamous CellIncidenceCommon neoplasmParotid neoplasmsBreastSalivary glandsPituitaryInvasionLocal
Carcinoma1
- The majority of cases (90%) of primary tracheal neoplasms in adults are malignant and among these 75% are represented by epithelial histotypes (mainly squamous cell carcinoma and adenoid cystic carcinoma) [ 3 , 4 ]. (imedpub.com)
Recurrence1
- The mechanisms whereby MMP-9 expression influences tumor recurrence and invasiveness, and its association with angiogenesis, remains to be elucidated. (ox.ac.uk)
Brain neoplasms1
- Object: Malignant gliomas are incurable, primary brain neoplasms noted for their potential to extensively invade brain parenchyma. (elsevier.com)
Neoplastic1
- The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. (nih.gov)
Tumors8
- These tumors are the principle CNS neoplasm of neurofibromatosis type 1 (NF1) . (medscape.com)
- Thymic neuroendocrine neoplasms (Th-NENs) are extremely rare, with an age-adjusted annual incidence of 0.02 per 100,000 US population, and account for approximately 5% of thymic tumors and 0.4% of all neuroendocrine neoplasms ( 1 , 2 ). (amegroups.com)
- Pleomorphic adenoma (PA) is the most commonly found neoplasm amongst tumors of the major and minor salivary glands, originally called a mixed benign tumor in 1866 3-5 . (bvsalud.org)
- Tracheal tumors are rare neoplasms with extremely heterogeneous histological aspects and can be potentially life-threatening, due to airway obstruction. (imedpub.com)
- Tracheal tumors are extremely rare, representing less than 0.2% of all neoplasms of the respiratory system [ 1 ]. (imedpub.com)
- As concerns nonepithelial tracheal neoplasms, the distinction between benign and malignant forms is generally less evident than epithelial tumors [ 5 ], due to difficulties in histological classification of these rare tumors, thus hiding a potential malignant behavior. (imedpub.com)
- In agreement with other Authors, we believe that some tracheal tumors, even if benign, for their characteristics of invasiveness and recurrency, should always be considered as potentially malignant and thus require a more aggressive treatment [ 2 , 4 ]. (imedpub.com)
- Gastrointestinal stromal tumors formerly classified as either leiomyomas or leiomyosarcomas account for 2% of gastric neoplasms (see Gastric Stromal Tumors ). (medscape.com)
Biological1
- The distinction between benign and malignant neoplasms is usually based on morphological aspects, biological behavior, local invasiveness and metastatic spread. (imedpub.com)
Glandular1
- A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (nih.gov)
Morphological features1
- Astrocytomas comprise a wide range of neoplasms that differ in their extent of invasiveness, morphological features, tendency for progression, and clinical course. (medscape.com)
Staging2
- MRI is increasingly being used in determining the extent of local invasiveness of urethral neoplasms for accurate staging and preoperative planning. (medscape.com)
- The diagnosis of thymomas entails histological classification (cytological components), assessing the malignant potential (cytologic grade and invasiveness), and TNM staging. (cap.org)
Pancreatic2
- Pancreatic endocrine tumours (PETs) are rare and heterogeneous neoplasms, often diagnosed at metastatic stage, for which no cure is currently available. (elsevier.com)
- STAT5b confers gemcitabine chemoresistance and promotes cell adherence and invasiveness in pancreatic cancer cells. (cusabio.com)
Epithelial1
- A very rare malignant epithelial neoplasm of the pancreas composed of cystic structures lined by glycogen-rich clear cells, associated with local invasiveness often involving the spleen, duodenum and/or stomach and metastatic spread to the liver, peritoneum and/or lymph nodes. (cdc.gov)
Adenoma1
- Pleomorphic adenoma is the most common neoplasm in major and minor salivary glands. (bvsalud.org)
Histological aspects1
- The diversity of histological aspects displayed by neoplasms of the salivary glands causes great difficulty in terms of universal classification 1-2 . (bvsalud.org)
Apoptosis1
- Our findings provide new insight into the role of miR-34c in the prostate, exhibiting tumor suppressing effects on proliferation, apoptosis and invasiveness. (ox.ac.uk)
Proliferation2
- Methods: In 243 patients presenting with contrast-enhancing gliomas, estimates of the relative invasiveness of each patient's tumor, in terms of the ratio of net proliferation rate of the glioma cells to their net dispersal rate, were derived by applying a patient-specific mathematical model to routine pretreatment MR imaging. (elsevier.com)
- Recently, activation of two pathways that support proliferation and invasiveness of cancer cells, the Src family kinase (SFK) and mammalian target of rapamycin (mTOR) pathways, was demonstrated in PETs. (elsevier.com)
Matrigel1
- Lung tumor burden (visualized by bioluminescence imaging) was attenuated by D2O, and inhibition of invasiveness was also confirmed in an in vitro Matrigel transwell invasion assay. (cdc.gov)
Tumours1
- The expression frequencies of many CT antigens have been determined in a variety of neoplasms [ 11 ], but little is known about their expression in human NS tumours. (biomedcentral.com)
Differ1
- The sensitivity and specificity of the various modalities, such as survey radiography, ultrasonography (US) and X-ray computed tomography (CT) vary, and therefore, their abilities to distinguish tumor size, margins, and invasiveness differ. (veterinarypracticenews.com)
Extent1
- The effect of varying degrees of extent of resection on overall survival was assessed for cohorts of patients grouped by tumor invasiveness. (elsevier.com)
Surgical2
- Conclusions: These results suggest that our patient-specific, model-based estimates of tumor invasiveness have clinical utility in surgical decision making. (elsevier.com)
- Even if rare, tracheal neoplasms can be potentially lifethreatening, due to the involvement of the airway which may cause acute asphyctic syndromes, requiring a prompt diagnosis and correct treatment (endoscopic and/or surgical) in order to restore a normal air flow. (imedpub.com)
Thymic2
- Thymic neuroendocrine neoplasms (Th-NENs) are extremely rare. (amegroups.com)
- Thymic neoplasms account for less than 1% of all malignancies with an incidence of approximately 1-5 per million. (cap.org)
Resection2
- Our goal was to apply a mathematical modeling approach to estimate the overall tumor invasiveness on a patient-by-patient basis and determine whether gross total resection would improve survival in patients with relatively less invasive gliomas. (elsevier.com)
- Quantification of relative invasiveness assessed from routinely obtained pre-operative imaging provides a practical predictor of the benefit of gross total resection. (elsevier.com)
Diagnosis1
- Conclusions: Although our predetermined criterion for specificity was not statistically confirmed, radiological diagnosis of noninvasive lung cancer with a thin-section computed tomography scan corresponded well with pathological invasiveness. (elsevier.com)
Metastasis5
- Lysyl oxidase-like 2 (LOXL2) is associated with invasiveness and metastasis in breast cancer. (yonsei.ac.kr)
- Loss of E-cadherin, which is caused by several tumor-promoting factors, is associated with metastasis and poor prognosis in many neoplasms. (elsevier.com)
- Neoplasm Metastasis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- This graph shows the total number of publications written about "Neoplasm Metastasis" by people in this website by year, and whether "Neoplasm Metastasis" was a major or minor topic of these publications. (uchicago.edu)
- Below are the most recent publications written about "Neoplasm Metastasis" by people in Profiles. (uchicago.edu)
Colorectal Neoplasms1
- 15. [X-ray diagnosis of the invasiveness of colorectal neoplasms]. (nih.gov)
Colonic neoplasms1
- 7. [Arteriography of both mesenteric arteries in diagnosis of colonic neoplasms]. (nih.gov)
Skin Neoplasms1
- Reported percentages of sarcoid among skin diseases and skin neoplasms vary from 13% to 90% and 8% to 38% when considering ocular neoplasms. (intechopen.com)
Melanoma2
- The MWCNTs proved to guarantee the appropriate spatial arrangement of the mimetic allowing a stronger inhibition of migration and invasiveness of human melanoma (A375) cells compared to other multivalent constructs reported before. (cnrs.fr)
- PDGF-C enhances human melanoma invasiveness through activation of neuropilin-1, a co-receptor for VEGF receptors and contribute to a metastatic phenotype [2] . (hapres.com)
Squamous Cell1
- In squamous cell carcinomas the differentiation phenotype seems to be influenced by the cell of origin and the kind of driver mutation, both responsible for the invasiveness and aggressiveness of the tumor (37, 38). (ourworldisblue.com)
Incidence3
- [ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. (medscape.com)
- Thus, the small intestine is remarkably resistant to the development of benign or malignant neoplasms, particularly when compared to the high incidence rates of adenocarcinoma of the colon. (aacrjournals.org)
- There is no available data to estimate the incidence of this neoplasm in México. (amegroups.com)
Common neoplasm1
- Pleomorphic adenoma is the most common neoplasm in major and minor salivary glands. (bvsalud.org)
Parotid neoplasms3
- Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands. (medscape.com)
- The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the table below. (medscape.com)
- Common parotid neoplasms. (medscape.com)
Breast4
- YUHSpace: LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients. (yonsei.ac.kr)
- These clinical and preclinical data confirm that higher LOXL2 expression is associated with invasiveness of basal-like breast cancer cells and lower survival of breast cancer patients. (yonsei.ac.kr)
- mh:'Breast Neoplasms' OR (tw:(Mama* OR seio* OR breast* OR mamma* OR seno*) AND tw:(neopl. (bvsalud.org)
- INTRODUCTION: Breast cancer is the most frequent neoplasm among women, representing 24.5% of all types of cancer in this population. (bvsalud.org)
Salivary glands3
- Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. (medscape.com)
- Among salivary gland neoplasms, 80% arise in the parotid glands, 10-15% arise in the submandibular glands, and the remainder arise in the sublingual and minor salivary glands. (medscape.com)
- The diversity of histological aspects displayed by neoplasms of the salivary glands causes great difficulty in terms of universal classification 1-2 . (bvsalud.org)
Pituitary1
- Of the described mechanisms, only reduced E-cadherin/catenin expression and overexpression of hst gene seem to be relatively specific markers for prolactinoma invasiveness compared with other pituitary adenomas. (ox.ac.uk)
Invasion2
- These neoplasms are biologically unusual in that they rarely metastasize outside the neuraxis yet are capable of invasion of the brain parenchyma. (nih.gov)
- Lung tumor burden (visualized by bioluminescence imaging) was attenuated by D2O, and inhibition of invasiveness was also confirmed in an in vitro Matrigel transwell invasion assay. (cdc.gov)
Local1
- Malignant neoplasms have features, such as excessive growth, local invasiveness, and the ability to form distant metastases (Figure 2, Table 1). (tmc.gov.in)