Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A cell line derived from cultured tumor cells.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Neoplasms containing cyst-like formations or producing mucin or serum.
Tumors or cancer of the SKIN.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the LUNG.
An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Tumors or cancer of the human BREAST.
Tumors or cancers of the KIDNEY.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Tumors or cancer of the LIVER.
Tumors or cancer of the THYROID GLAND.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
DNA present in neoplastic tissue.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
A malignant epithelial tumor with a glandular organization.
Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Tumors or cancer of the COLON.
Adherence of cells to surfaces or to other cells.
Tumors or cancer of the PAROTID GLAND.
A benign epithelial tumor with a glandular organization.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Tumors or cancer of the APPENDIX.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Tumors or cancer located in bone tissue or specific BONES.
A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tumors or cancer of the ENDOCRINE GLANDS.
A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Tumors or cancer of the STOMACH.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Tumors or cancer of the PROSTATE.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Tumors or cancer of the BILE DUCTS.
Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Tumors or cancer of the EYE.
Tumors or cancer of the NOSE.
Glycoproteins which have a very high polysaccharide content.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Tumors or cancer of the SALIVARY GLANDS.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
Tumors or cancer of the MOUTH.
Tumors or cancer of the THYMUS GLAND.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.
Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.
Tumors or cancer of the URINARY BLADDER.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
A widely expressed transmembrane glycoprotein that functions as a METASTASIS suppressor protein. It is underexpressed in a variety of human NEOPLASMS.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
An extracellular receptor specific for UROKINASE-TYPE PLASMINOGEN ACTIVATOR. It is attached to the cell membrane via a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE and plays a role in the co-localization of urokinase-type plasminogen activator with PLASMINOGEN.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Tumors or cancer of the UTERUS.
Tumors or cancer of the INTESTINES.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.
A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.
Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition.
Compounds that inhibit the enzyme activity or activation of MATRIX METALLOPROTEINASES.
Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A general term for various neoplastic diseases of the lymphoid tissue.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Neoplasms composed of more than one type of neoplastic tissue.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Tumors or cancer of the MANDIBLE.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Tumors or cancer of the SPLEEN.
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
RNA present in neoplastic tissue.
Cancer or tumors of the MAXILLA or upper jaw.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.
Transplantation between animals of different species.
Tumors or cancer of the anal gland.
Established cell cultures that have the potential to propagate indefinitely.
Experimentally induced tumors of the LIVER.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
An intermediate filament protein found in most differentiating cells, in cells grown in tissue culture, and in certain fully differentiated cells. Its insolubility suggests that it serves a structural function in the cytoplasm. MW 52,000.
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.
Neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
Tumors or cancer of the DUODENUM.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Non-native organisms brought into a region, habitat, or ECOSYSTEM by human activity.
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Tumors or cancer of the PERITONEUM.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Tumors or cancers of the ADRENAL CORTEX.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Tumors or cancer of the MEDIASTINUM.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations of the gene for PROTO-ONCOGENE PROTEINS C-MET are associated with papillary renal carcinoma and other neoplasia.
Tumors or cancer of the TONGUE.
Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.
Interruption or suppression of the expression of a gene at transcriptional or translational levels.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Tumors or cancer of the VAGINA.
The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE-STRANDED RNA, such as SMALL INTERFERING RNA and RNA containing HAIRPIN LOOP SEQUENCE, and ANTI-SENSE OLIGONUCLEOTIDES.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.
A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
The smallest member of the MATRIX METALLOPROTEINASES. It plays a role in tumor progression.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Clonal myeloid disorders that possess both dysplastic and proliferative features but are not properly classified as either MYELODYSPLASTIC SYNDROMES or MYELOPROLIFERATIVE DISORDERS.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
Surgical removal of the pancreas. (Dorland, 28th ed)
A class of enzymes that catalyzes the degradation of gelatin by acting on the peptide bonds. EC 3.4.24.-.
Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)
Elements of limited time intervals, contributing to particular results or situations.
Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a N-glycosylated protein, molecular weight 28 kD, produced by a vast range of cell types and found in a variety of tissues and body fluids. It has been shown to suppress metastasis and inhibit tumor invasion in vitro.
Tumors or cancer of the PARANASAL SINUSES.
Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
Matrix metalloproteinases that are associated with the CELL MEMBRANE, either through transmembrane domains or GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORS. Membrane-type matrix metalloproteinases may act within the pericellular environment to influence the process of CELL MIGRATION.
The middle germ layer of an embryo derived from three paired mesenchymal aggregates along the neural tube.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Cancers or tumors of the MAXILLA or MANDIBLE unspecified. For neoplasms of the maxilla, MAXILLARY NEOPLASMS is available and of the mandible, MANDIBULAR NEOPLASMS is available.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Tumors or cancer of the ESOPHAGUS.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Neoplasms of the bony orbit and contents except the eyeball.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
ENDOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Enzymes that catalyze the degradation of collagen by acting on the peptide bonds.

Immunohistochemical expression of mdm2 and p21WAF1 in invasive cervical cancer: correlation with p53 protein and high risk HPV infection. (1/11529)

AIM: To investigate the immunocytochemical staining pattern of mdm2 and p21WAF1 proteins in invasive cervical cancer and to determine its relation with the expression of p53 and with the high risk HPV infection. METHODS: Immunocytochemistry for p53, mdm2, and p21WAF1 was performed in 31 paraffin embedded sections of invasive cervical cancer. The results were assessed by image analysis, evaluating for each protein the optical density of the immunostained area, scored as percentage of the total nuclear area. The presence of high risk human papillomavirus (HPV) infection was detected by using the polymerase chain reaction. RESULTS: Immunostaining for both mdm2 and p21WAF1 was correlated with p53 expression; however, the correlation between p53 and mdm2 (R = 0.49; p < 0.01) was more significant than between p53 and p21WAF1 (R = 0.31; p < 0.05); the less stringent correlation between p53 and p21WAF1 might reflect the p53 independent mechanisms of p21WAF1 induction. Similar average levels of p53, mdm2, and p21WAF1 immunostaining were found in the presence or absence of high risk HPV-DNA, without significant differences between the two groups. CONCLUSIONS: These data suggest that mdm2 and p21WAF1 proteins are expressed in invasive cervical cancer and that their immunocytochemical staining pattern is not abrogated by the presence of high risk HPV genomic sequences.  (+info)

The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells. (2/11529)

The acquisition of invasiveness is a crucial step in the malignant progression of cancer. In cancers of the colon and of other organs the E-cadherin/catenin complex, which is implicated in homotypic cell-cell adhesion as well as in signal transduction, serves as a powerful inhibitor of invasion. We show here that one allele of the alphaE-catenin (CTNNA1) gene is mutated in the human colon cancer cell family HCT-8, which is identical to HCT-15, DLD-1 and HRT-18. Genetic instability, due to mutations in the HMSH6 (also called GTBP) mismatch repair gene, results in the spontaneous occurrence of invasive variants, all carrying either a mutation or exon skipping in the second alphaE-catenin allele. The alphaE-catenin gene is therefore, an invasion-suppressor gene in accordance with the two-hit model of Knudsen for tumour-suppressor genes.  (+info)

Role of thrombin receptor in breast cancer invasiveness. (3/11529)

Invasion, the ability of an epithelial cancer cell to detach from and move through a basement membrane, is a central process in tumour metastasis. Two components of invasion are proteolysis of extracellular matrix and cellular movement through it. A potential promoter of these two processes is thrombin, the serine proteinase derived from the ubiquitous plasma protein prothrombin. Thrombin promotes the invasion of MDA-MB231 breast tumour cells (a highly aggressive cell line) in an in vitro assay. Invasion by MDA-MB436 and MCF-7 cells, less aggressive cell lines, is not promoted by thrombin. Thrombin, added to the cells, is a stimulator of cellular movement; fibroblast-conditioned medium is the chemotaxin. Thrombin-promoted invasion is inhibited by hirudin. Stimulation of invasion is a receptor-mediated process that is mimicked by a thrombin receptor-activating peptide. Thrombin has no effect on chemotaxis in vitro. Thrombin receptor is detectable on the surface of MDA-MB231 cells, but not on the other two cell lines. Introduction of oestrogen receptors into MDA-MB231 cells by transfection with pHEO had no effect on thrombin receptor expression, in the presence or absence of oestradiol. This paper demonstrates that thrombin increases invasion by the aggressive breast cancer cell line MDA-MB231 by a thrombin receptor-dependent mechanism.  (+info)

Expression of pyrimidine nucleoside phosphorylase mRNA plays an important role in the prognosis of patients with oesophageal cancer. (4/11529)

To clarify the significance of the expression of pyrimidine nucleoside phosphorylase (PyNPase) mRNA as a predictive factor for the prognosis of patients with oesophageal carcinoma, the PyNPase mRNA in the tumours and normal tissues from 55 resected cases of oesophageal carcinoma was examined by a reverse transcription polymerase chain reaction (RT-PCR). As a result, a positive correlation was observed between the tumour/normal (T/N) ratio of the expression of PyNPase mRNA by RT-PCR and that of the enzyme activity of PyNPase based on the findings of an enzyme linked immunosolvent assay (r = 0.594, P = 0.009). The T/N ratio of the expression of PyNPase mRNA was significantly higher in the cases with lymph vessel invasion (P = 0.013), lymph node metastasis (P = 0.0016), and an advanced stage of the disease (P = 0.021) than those without these factors. The patients with a higher T/N ratio of PyNPase mRNA showed significantly worse prognosis than those with a lower T/N ratio (P = 0.023 with log-rank tests). A multivariate analysis for the cumulative survival rates revealed that a high T/N ratio of the expression of PyNPase mRNA was independently related to a poor prognosis. These findings suggested that the determination of PyNPase mRNA by RT-PCR thus appears to be a new useful parameter for identifying both a poor prognosis and a highly malignant potential of oesophageal carcinoma.  (+info)

Low tumour cell proliferation at the invasive margin is associated with a poor prognosis in Dukes' stage B colorectal cancers. (5/11529)

The conflicting results about the prognostic impact of tumour cell proliferation in colorectal cancer might be explained by the heterogeneity observed within these tumours. We have investigated whether a systematic spatial heterogeneity exists between different compartments, and whether the presence of such a systematic heterogeneity has any impact on survival. Fifty-six Dukes' stage B colorectal cancers were carefully morphometrically quantified with respect to the immunohistochemical expression of the proliferative marker Ki-67 at both the luminal border and the invasive margin. The proliferative activity was significantly higher at the luminal border compared with the invasive margin (P<0.001), although the two compartments were also significantly correlated with each other. Tumours with low proliferation at the invasive margin had a significantly poorer prognosis both in univariate (P = 0.014) and in multivariate survival analyses (P = 0.042). We conclude that Dukes' B colorectal cancers exhibit a systematic spatial heterogeneity with respect to proliferation, and tumours with low proliferation at the invasive margin had a poor prognosis. The present data independently confirm recent results from the authors, and provide new insights into the understanding of tumour cell proliferation in colorectal cancer.  (+info)

A possible involvement of aberrant expression of the FHIT gene in the carcinogenesis of squamous cell carcinoma of the uterine cervix. (6/11529)

To investigate involvement of an aberrant expression of the FHIT (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by the reverse transcriptase polymerase chain reaction (RT-PCR) and cDNA sequence method in 32 cervical invasive carcinomas (25 squamous cell carcinomas and seven adeno- or adenosquamous carcinomas) and 18 of its precursor lesions [four low-grade and 14 high-grade cervical intraepithelial neoplasias (CINs)]. We also examined a link between the occurrence of the aberrant expression and human papillomavirus (HPV). We detected the aberrant FHIT transcripts in 11 of 25 (44%) cervical invasive squamous cell carcinomas and in 5 of 14 (36%) high-grade CINs (CIN 2 or 3), whereas they were not found in seven non-squamous type and four low-grade CINs (CIN 1). The alteration patterns of the FHIT gene expression in high-grade CINs were virtually similar to those found in invasive carcinomas, such that the exons 5-7 were consistently deleted associated or unassociated with loss of the exon 4 and/or 8. The incidence of the aberrant expression was not related to the presence of HPV and its type. These data indicate that the aberrant expression of the FHIT gene is observed in precursor lesions of cervical carcinoma as well as invasive carcinomas, with its incidence not increasing with advance of clinical stage. Given the squamous cell type dominant expression, the aberrant expression may play a critical role in the generation of squamous cell carcinoma of the uterine cervix, but not the consequence of the progression of the cancer.  (+info)

Enhanced tumor growth and invasiveness in vivo by a carboxyl-terminal fragment of alpha1-proteinase inhibitor generated by matrix metalloproteinases: a possible modulatory role in natural killer cytotoxicity. (7/11529)

Matrix metalloproteinases (MMPs) are believed to contribute to the complex process of cancer progression. They also exhibit an alpha1-proteinase inhibitor (alphaPI)-degrading activity generating a carboxyl-terminal fragment of approximately 5 kd (alphaPI-C). This study reports that overexpression of alphaPI-C in S2-020, a cloned subline derived from the human pancreas adenocarcinoma cell line SUIT-2, potentiates the growth capability of the cells in nude mice. After stable transfection of a vector containing a chimeric cDNA encoding a signal peptide sequence of tissue inhibitor of metalloproteinase-1 followed by cDNA for alphaPI-C into S2-020 cells, three clones that stably secrete alphaPI-C were obtained. The ectopic expression of alphaPI-C did not alter in vitro cellular growth. However, subcutaneous injection of the alphaPI-C-secreting clones resulted in tumors that were 1.5 to 3-fold larger than those of control clones with an increased tendency to invasiveness and lymph node metastasis. These effects could be a result of modulation of natural killer (NK) cell-mediated control of tumor growth in nude mice, as the growth advantage of alphaPI-C-secreting clones was not observed in NK-depleted mice, and alphaPI-C-secreting clones showed decreased NK sensitivity in vitro. In addition, production of alphaPI and generation of the cleaved form of alphaPI by MMP were observed in various human tumor cell lines and in a highly metastatic subline of SUIT-2 in vitro. These results provide experimental evidence that the alphaPI-degrading activity of MMPs may play a role in tumor progression not only via the inactivation of alphaPI but also via the generation of alphaPI-C.  (+info)

Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas. (8/11529)

Collagenase-3 (MMP-13) is a human matrix metalloproteinase specifically expressed by invading tumor cells in squamous cell carcinomas (SCCs) of the head and neck. Here, we have further elucidated the role of MMP-13 in tumor invasion by examining its expression in invasive malignant tumors of the female genital tract. Using in situ hybridization, expression of MMP-13 mRNA was detected in 9 of 12 vulvar SCCs, primarily in tumor cells, but not in intact vulvar epithelium, in cervical SCCs (n = 12), or in endometrial (n = 11) or ovarian adenocarcinomas (n = 8). MMP-13 expression was especially abundant in vulvar carcinomas showing metastasis to lymph nodes and was associated with expression of membrane type 1 MMP by tumor cells and gelatinase-A (MMP-2) by stromal cells, as detected by immunohistochemistry. MMP-13 mRNAs were detected in 9 of 11 cell lines established from vulvar carcinomas and in 4 of 6 cell lines from cervical carcinomas, whereas endometrial (n = 10) and ovarian (n = 9) carcinoma cell lines were negative for MMP-13 mRNA. No correlation was detected between MMP-13 expression and p53 gene mutations in vulvar SCC cell lines. However, MMP-13 expression was detected in 5 of 6 vulvar and cervical SCC cell lines harboring HPV 16 or 68 DNA. These results show that MMP-13 is specifically expressed by malignantly transformed squamous epithelial cells, including vulvar SCC cells, and appears to serve as a marker for their invasive capacity.  (+info)

Keywords: Arsenic trioxide, Thalidomide, Vascular Endothelial Development Factor (VEGF), severe myeloid leukemia Launch Severe myeloid leukemia (AML) may be the heterogeneous malignant which is normally seen as a the uncontrolled proliferation of hematopoietic stem cells and myeloid (D?hner et al., 2015; Mohammadi et al., 2016). Although with typical AML regiment many sufferers obtain remission originally, but ultimately relapse occur because of chemotherapy evaded leukemic stem cells (Mohammadi et al., 2017a; Mohammadi et al., 2017b). Angiogenesis is normally a regulated procedure, which creates brand-new arteries from a pre-existing vascular network (Kerbel, 2008), and has an important function in the development of hematolymphoid malignancies. Vascular Endothelial Development Factor (VEGF) is normally a 46 KD heparin-binding homodimer protein including six different isoforms specifically VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E and VEGF-F (Tischer et al., 1991; Lei et al., 1998; Mirzaei et al., ...
Relationship between Tumor Cell Invasiveness and Polyploidization. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2), an enzyme mediating 3-O-sulfation of heparan sulfate (HS), is silenced by hypermethylation in breast cancer. As HS has an important co-receptor function for numerous signal transduction pathways, the phenotypical changes due to HS3ST2 reexpression were investigated in vitro using high and low invasive breast cancer cell lines. Compared to controls, highly invasive HS3ST2-expressing MDA-MB-231 cells showed enhanced Matrigel invasiveness, transendothelial migration and motility. Affymetrix screening and confirmatory real-time PCR and Western blotting analysis revealed increased expression of several matrix metalloproteinases, cadherin-11, E-cadherin and CEACAM-1, while protease inhibitor and annexin A10 expression were decreased. Low invasive HS3ST2 -expressing MCF-7 cells became even less invasive, with no change in gelatinolytic MMP activity. HS3ST2 expression increased HS-dependent basal and FGF2-specific signaling through the constitutively ...
By using microarray and an invasion/metastasis lung cell line model, we identified the DnaJ-like heat shock protein 40, HLJ1, and found that the expression of HLJ1 correlates negatively with cancer cell invasion ability . Overexpression of HLJ1 can suppress cancer cell invasion in vitro. We further characterize the putative promoter region and investigate the transcriptional regulations of human HLJ1. A serial deletion of the 1.2 kb at the 5′-flanking region of the human HLJ1 gene was subcloned into a vector containing reporter gene and transfected into human lung adenocarcinoma cell line CL1-0, followed by luciferase activity assay. The results indicated that the region from -232 to +176 could drive the basal transcriptional activity of the HLJ1 gene. Sequence analysis of the HLJ1 gene promoter region showed absence of a TATA box, but identified an inverted CCAAT box and four YY1 transcriptional factor-binding sites, which may be important in the regulation of HLJ1 expression. Co- ...
Cancer invasion involves the growth of the tumor and the invasion of cancer cells. During this process, the tumor typically elongates protrusion-like structures, which triggers the invasion of cells into the blood vessel, and thereby, initiate metastasis. Recent evidences using individual cells have identified the key role of membrane protrusion fluctuations in the physicochemical mechanism of directed cell motion]. The exact roles of protrusion fluctuations during tumor growth and invasion have yet not been reported. Different in vitro and in vivo models have been developed to monitor cancer invasion and its mechanistic determinants. These models display certain limitations, which threaten the relevancy of the obtained data. In contrast, organs-on-chip devices can replicate all the key cellular, structural, and rheological properties of solid tumors, contributing to assess the mechanism at work of the disease. In this work, an organ-on-chip approach is used to analyze the important role of ...
MT1-MMP drives cancer cell invasion and intravasation. (A and B) HT-1080 or SCC-1 cells were incubated alone with TIMP-1, TIMP-2, a 21-bp MT1-MMP siRNA, or a 21
guys... PMs are very very good things to straighten out differences...to talk below the water line so as not to upset some of our more gentle folk..and to
guys... PMs are very very good things to straighten out differences...to talk below the water line so as not to upset some of our more gentle folk..and to
The results of the current study showed the molecular and functional activation of β-catenin by hypoxia in HCC and showed its contribution to hypoxia-induced metastatic phenotypes. The induction of EMT was one of the proinvasive mechanisms augmented by β-catenin during hypoxia. The coexpression of β-catenin and HIF-1α (a marker of hypoxia) in HCC was found to be correlated with metastases and poor prognosis in two independent cohorts of patients. These results confirm the importance of β-catenin in HCC under hypoxic conditions.. Hypoxia plays a critical role in tumor progression (1). Consistent with our previous report (17), it not only facilitated in vitro cell invasion in HCC but also resulted in peritoneal seeding and pulmonary metastasis in an in vivo HAL model. However, the growth of HCC cells and xenografts were suppressed by hypoxia. Further analysis revealed that this could be attributed to the arrest of cell proliferation rather than the induction of apoptosis (Supplementary Fig. ...
Fingerprint Dive into the research topics of ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasation. Together they form a unique fingerprint. ...
One year of biology and chemistry and physics or equal courses of all three subjects. Obviously, if illness is prevented by pure means earlier than resulting in the breakdown of the immune system which is the bodys mechanism of defence towards illness, severe illnesses equivalent to most cancers and other so-known as incurable diseases can be revented, and so there would be little need for the administration of high-priced conventional drugs since that might be obligatory solely in case of surgery and different traumatic circumstances.. In vitro studies have demonstrated that melatonin induces apoptosis and reduces breast cancer invasiveness and metastasis. The curriculum is designed to permit the scholar to gain the data essential to work in the different medicine setting. But the battle has prevented folks from exercising various medical treatments.. In the event you (or someone you already know) are concerned about finding an appropriate alternative medication university to assist attain ...
Perineural invasion (PNI) is the neoplastic invasion of nerves. PNI is widely recognized as an important adverse pathological feature of many malignancies, including pancreatic, prostate, and head and neck cancers and is associated with a poor prognosis.
Proteolytic degradation of the extracellular matrix plays a crucial role in both cancer invasion and non-neoplastic tissue remodeling processes. In human cancers the components of matrix degrading protease systems (uPA, uPAR, PAI-1 and MMPs) can be expressed by either the non-neoplastic stromal cell …
해설: 최종 병리 결과 병변은 중등도 분화도를 보이는 편평세포암이었고, 크기는 4.8 x 3.7 cm 이었습니다. 수직방향으로 lamina propria 까지 침윤하였고, 절제면에 종양세포는 없었습니다. Lymphovascular invasion 및 perineural invasion 없었습니다. 일반적으로 식도 ESD 후 발생가능한 합병증으로는 출혈, 천공, 협착이 있으며, 이 증례의 경우 360도 절제를 하여 협착이 특히 우려되었습니다. 서울아산병원 경험에 의하면, 전체 ESD 환자 중 합병증은 약 13%에서 발생하였으며, 협착 (6.5%), 천공 (4.6%), 출혈 (1.5%) 순이었습니다. 본 증례에서는 협착을 예방하기 위해 병변이 제거된 궤양 바닥에 스테로이드를 시술 중 바로 주입하였습니다 (그림2, D). 이후 환자는 협착 증상 없이 위 림프종 항암치료를 무사히 마칠 수 있었습니다. 식도 ESD 후 협착의 예방 및 치료에는 스테로이드 ...
The initiation and progression of cancer is closely associated with the tumor microenvironment. The overexpression of oncogenes during tumor growth and progression by stromal stimuli can affect the...
Oct 06, 2016 · Malfunction of Rabs-regulating vesicle trafficking could promote cancer invasion. For example, Rab11 is an important component for membrane proteins recycling and proteins transport from TGN to the plasma membrane. Rab11-mediated α6β4 integrin trafficking has been found to contribute to increase cancer cell invasion in breast cancer.
BACKGROUND: Ubiquitination is a highly dynamic and reversible process with a central role in cell homeostasis. Deregulation of several deubiquitinating enzymes has been linked to tumor development but their specific role in prostate cancer progression remains unexplored. METHODS: RNAi screening was used to investigate the role of the ovarian tumor proteases (OTU) family of deubiquitinating enzymes on the proliferation and invasion capacity of prostate cancer cells. RhoA activity was measured in relation with OTUB1 effects on prostate cancer cell invasion. Tumor xenograft mouse model with stable OTUB1 knockdown was used to investigate OTUB1 influence in tumor growth. RESULTS: Our RNAi screening identified OTUB1 as an important regulator of prostate cancer cell invasion through the modulation of RhoA activation. The effect of OTUB1 on RhoA activation is important for androgen-induced repression of p53 expression in prostate cancer cells. In localized prostate cancer tumors OTUB1 was found overexpressed as
BACKGROUND: Ubiquitination is a highly dynamic and reversible process with a central role in cell homeostasis. Deregulation of several deubiquitinating enzymes has been linked to tumor development but their specific role in prostate cancer progression remains unexplored. METHODS: RNAi screening was used to investigate the role of the ovarian tumor proteases (OTU) family of deubiquitinating enzymes on the proliferation and invasion capacity of prostate cancer cells. RhoA activity was measured in relation with OTUB1 effects on prostate cancer cell invasion. Tumor xenograft mouse model with stable OTUB1 knockdown was used to investigate OTUB1 influence in tumor growth. RESULTS: Our RNAi screening identified OTUB1 as an important regulator of prostate cancer cell invasion through the modulation of RhoA activation. The effect of OTUB1 on RhoA activation is important for androgen-induced repression of p53 expression in prostate cancer cells. In localized prostate cancer tumors OTUB1 was found overexpressed as
TY - JOUR. T1 - The mode and dynamics of glioblastoma cell invasion into a decellularized tissue-derived extracellular matrix-based three-dimensional tumor model. AU - Koh, Ilkyoo. AU - Cha, Junghwa. AU - Park, Junseong. AU - Choi, Junjeong. AU - Kang, Seok Gu. AU - Kim, Pilnam. PY - 2018/3/1. Y1 - 2018/3/1. N2 - Glioblastoma multiforme (GBM) is the most common brain tumor with very aggressive and infiltrative. Extracellular matrix (ECM) plays pivotal roles in the infiltrative characteristics of GBM. To understand the invasive characteristic of GBM, it is necessary to study cell-ECM interaction in the physiologically relevant biomimetic model that recapitulates the GBM-specific ECM microenvironment. Here, we propose biomimetic GBM-specific ECM microenvironment for studying mode and dynamics of glioblastoma cell invasion. Using tissue decellularization process, we constructed a patient tissue-derived ECM (pdECM)-based three-dimensional in vitro model. In our model, GBM cells exhibited ...
Peroxisome proliferator-activated receptor β (PPARβ) and NaV1.5 voltage-gated sodium channels have independently been shown to regulate human breast cancer cell invasiveness. The n-3 polyunsaturated docosahexaenoic acid (DHA, 22:6n-3), a natural ligand of PPAR, is effective in increasing survival and chemotherapy efficacy in breast cancer patient with metastasis. DHA reduces breast cancer cell invasiveness and it also inhibits PPARβ expression. We have shown previously that NaV1.5 promotes MDA-MB-231 breast cancer cells invasiveness by potentiating the activity of Na(+)/H(+) exchanger type 1 (NHE-1), the major regulator of H(+) efflux in these cells. We report here that DHA inhibited NaV1.5 current and NHE-1 activity in human breast cancer cells, and in turn reduced NaV1.5-dependent cancer cell invasiveness. For the first time, we show that antagonizing PPARβ, or inhibiting its expression, reduced NaV1.5 mRNA and protein expression and NaV1.5 current, as well as NHE-1 activity and cell ...
We demonstrate that the alpha6beta4 integrin promotes carcinoma invasion through a preferential and localized targeting of phosphoinositide-3 OH kinase (PI3K) activity. Stable expression of alpha6beta4 increased carcinoma invasion in a PI3K-dependent manner, and transient expression of a constitutiv …
Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is implicated in many cancers; however, it is unclear specifically which EGFR pathways are involved in triggering tumor cell invasiveness. The abundance of the small guanosine triphosphatase Arf6, which regulates processes such as membrane trafficking and endocytosis, correlates with the invasiveness of malignant breast cancer cells. In this context, Morishige et al. used small interfering RNA (siRNA) to individually decrease the expression of the 10 genes that encode guanine nucleotide exchange factors (GEFs) that activate Arf family proteins in the invasive human breast cancer cell line MDA-MB-231. GEP100 was the only ArfGEF whose depletion resulted in the inhibition of MDA-MB-231 invasion activity, as measured by an in-gel invasiveness assay. Coimmunoprecipitation studies showed that EGF treatment of MDA-MB-231 cells triggered the association of GEP100 with EGFR. In transfected Cos-7 cells, the authors showed the ...
Purified Cell Invasion Assay (Basement Membrane), 24-well, 8 μm from Creative Biomart. Cell Invasion Assay (Basement Membrane), 24-well, 8 μm can be used for research.
TY - JOUR. T1 - Tumor volume and lymphovascular space invasion as a prognostic factor in early invasive adenocarcinoma of the cervix. AU - Murakami, Isao. AU - Fujii, Takuma. AU - Kameyama, Kaori. AU - Iwata, Takashi. AU - Saito, Miyuki. AU - Kubushiro, Kaneyuki. AU - Aoki, Daisuke. PY - 2012/6. Y1 - 2012/6. N2 - Objective: The aim of this study was to investigate the risk and recurrence of early invasive adenocarcinoma of the cervix, and to determine whether non-radical methods of management could be performed. Methods: The medical and histopathological records of 50 patients with early invasive adenocarcinoma of the cervix treated at Keio University Hospital between 1993 and 2005 were reviewed, and compared with the literature. Results: The median follow-up period was 64.3 months. The depth of stromal invasion was ≤3 mm in 33 cases and ,3 mm, but ≤5 mm in 17 cases. The horizontal spread was ≤7 mm in 25 cases and ,7 mm in 25 cases. One of the 33 cases that had tumor volumes of ≤500 mm ...
Background Stromal fibroblasts can contribute to tumor invasion through the release of matrix metalloproteinases (MMPs). Population studies have suggested that single nucleotide polymorphisms (SNPs) in MMP genes influence levels of expression and may be associated with breast cancer risk and with disease progression. This study directly examined the impact of MMP SNP genotype on the ability of host fibroblasts to promote tumor cell invasion. Methods Primary breast fibroblasts were isolated from patients with (n = 13) or without (n = 19) breast cancer, and their ability to promote breast cancer cell invasion was measured in in vitro invasion assays. Fibroblast invasion-promoting capacity (IPC) was analyzed in relation to donor type (tumor or non-tumor patient), MMP-1, MMP-3, and MMP-9 SNP genotype and MMP activity using independent samples t test and analysis of variance. All statistical tests were two-sided. Results Tumor-derived fibroblasts promoted higher levels of invasion than normal ...
Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian cancers have different metastatic phenotypes. To investigate if platelet-cancer cell interactions play a role, we characterized the response of ovarian cancer cell lines to platelets both functionally and at a molecular level. Cell lines 59 M and SK-OV-3 were used as in vitro model systems of metastatic ovarian cancer. Platelet cloaking of each cell line was quantified by flow cytometry. Matrigel invasion chamber assays were used to assess the invasive capacity of the cell lines. The induction of an EMT was assessed by morphology analysis and by gene expression analysis of a panel of 11 EMT markers using TaqMan RT-PCR. SK-OV-3 cells adhered to and activated more platelets than 59 M cells (p = 0.0333). Platelets significantly promoted the ability of only SK-OV-3 cells to invade (p ≤ 0.0001).
Sigma-Aldrich offers abstracts and full-text articles by [Hai Zhang, Shanyu Cheng, Min Zhang, Xiuping Ma, Li Zhang, Yipin Wang, Rong Rong, Juan Ma, Shukai Xia, Mingzhan Du, Feng Shi, Jie Wang, Qinyi Yang, Xiaoming Bai, Jing Leng].
4360 Secreted acidic protein rich in cysteine (SPARC) has been suggested as a potential glioma invasion promoting gene. SPARC is highly expressed in human gliomas, promotes glioma invasion, and delays tumor growth in vitro and in vivo. cDNA array reports were performed to determine whether SPARC, which interacts at the cell surface, has an impact on intracellular signaling and downstream gene expression changes that might account for some of its effects on invasion and growth. Additional in vitro studies demonstrated that SPARC delays growth, increases attachment, and modulates migration of tumor cells in extracellular matrix-specific and concentration-dependent manners. It has been reported that SPARC functionally contributes to brain tumor invasion and delays tumor growth in vivo, and that the effects of SPARC are related to the level of SPARC secreted into the extracellular matrix. Thus far, the signaling aspects of glioma migration and invasion are not fully understood. As such, we made an ...
Furin, a subtilisin/kesin-like proprotein convertase (PC), activates membrane-bound MT1-MMP, which facilitates pro-gelatinase A (MMP2). These activated MT1-MMP and MMP2 are involved in cancer cell invasion and metastasis. In this study, we investigate the contribution of MMP2 activated by furin to cellular invasiveness of cumulatively irradiated cells.. Using previously established AMC-HN3 and AMC-HN8 cell line from laryngeal carcinoma patient, we have generated isogenic model of cumulatively irradiated AMC-HN3R and AMC-HN8R cell line, respectively. AMC-HN3R cells were increased furin expression with upregulation of MT1-MMP/MMP2 and their invasiveness by two fold (p , 0.05) compared to AMC-HN3, while AMC-HN8R cells had no differences compared to AMC-HN8. In case of AMC-HN3R, inhibition of furin activity with the synthetic inhibitor decanoyl-Arg-Val-Lys-Arg-chloromethyl-keton, CMK, showed a significant decrease of MT1-MMP/MMP2 and in vitro cellular invasiveness. Tumors obtained after subcutaneous ...
TY - JOUR. T1 - EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1. AU - Lau, Steven K.M.. AU - Shields, David J.. AU - Murphy, Eric A.. AU - Desgrosellier, Jay S.. AU - Anand, Sudarshan. AU - Huang, Miller. AU - Kato, Shumei. AU - Lim, Ssang Taek. AU - Weis, Sara M.. AU - Stupack, Dwayne G.. AU - Schlaepfer, David D.. AU - Cheresh, David A.. PY - 2012/5/7. Y1 - 2012/5/7. N2 - Receptor tyrosine kinases and integrins play an essential role in tumor cell invasion and metastasis. We previously showed that EGF and other growth factors induce human carcinoma cell invasion and metastasis mediated by integrin αvβ5 that is prevented by Src blockade [1]. MUC1, a transmembrane glycoprotein, is expressed in most epithelial tumors as a heterodimer consisting of an extracellular and a transmembrane subunit. The MUC1 cytoplasmic domain of the transmembrane subunit (MUC1.CD) translocates to the nucleus where it promotes the transcription of ...
Salmonellosis is one of the most common and widely distributed food borne diseases caused by Salmonella enterica serovar Typhi (S.Typhi). Powerful str..
Fig. 3 PTENs intact PDZ binding domain is required for antagonism of PREX2-driven invasion, and the PTEN C2-tail is sufficient to suppress invasion.. (A) PREX2 drives invasion. BT549 cells were transfected as indicated and subjected to invasion assays using an FBS gradient or no gradient. (B) PTEN constructs used in invasion assays. (C) PTEN C2-tail, G129E, and C124S block PREX2-driven invasion. BT549 cells were transfected as indicated, and invasion experiments were performed using an FBS gradient. (D) Immunoblots showing PREX2 and PTEN from cells used in invasion assays. Lysates from breast cancer cell lines with endogenous PTEN are shown. (E) C2-tail antagonizes PREX2-driven invasion in SUM149 cells. SUM149 cells were transfected as indicated, and invasion experiments were performed. (F) Coimmunoprecipitation of PTEN constructs and PREX2. BT549 cells were transfected with V5-PREX2 along with the indicated FLAG-PTEN constructs. (G) Schematic showing the binding of the PTEN PDZ binding domain ...
Die Universität zu Köln ist eine Exzellenzuniversität mit dem klassischen Fächerspektrum einer Volluniversität. Als eine der größen Hochschulen Europas arbeitet sie in Forschung und Lehre auch international auf höchstem Niveau.
Chemotherapy is widely used to treat metastatic disease. However, while many patients initially respond, a high percentage of them ultimately relapse. Cells plated in a monolayer respond much better to cytotoxic therapy than the same cells grown in 3D spheroids, or in xenograft tumors in mice, suggesting that the ECM and stromal cells that make up the tumor microenvironment drive drug resistance. While there has been work highlighting mechanisms of resistance derived from the release of cytokines from stromal cells, the role of the ECM in this process remains understudied in 3D in vitro systems or in vivo using mouse models. In addition, how chemotherapy treatment alters the ECM remains unknown. Finally, most studies focus on the effect chemotherapeutics on cell death, while the potentially dangerous effects of these drugs on tumor cell invasion and metastatic capability remain understudied. Our preliminary data show that chemotherapeutics can have different effects on growth and motility in ...
Celldance 2015: Spying on Cancer Cell Invasion, by Edison Leung with Allison Harney, John Condeelis lab, Albert Einstein College of Medicine.
Perineural invasion (PNI) is thought to be one of the factors responsible for the high rate of tumor recurrence after surgery and the pain generation associated with pancreatic cancer. Signaling via the nerve growth factor (NGF) pathway between pancreatic cancer cells and the surrounding nerves has been implicated in PNI, and increased levels of these proteins have been correlated to poor prognosis. In this study, we examine the molecular mechanism of the NGF signaling pathway in PNI in pancreatic cancer. We show that knocking down NGF or its receptors, TRKA and p75NTR, or treatment with GW441756, a TRKA kinase inhibitor, reduces the proliferation and migration of pancreatic cancer cells in vitro ...
Publications (* co-first): Kim HD*, Sileika TS*, Maniak P, Messersmith PB. Antibacterial performance of polydopamine modified polymer surfaces containing passive and active components. Submitted. 2011 Kim HD, Peyton SR. Bio-inspired materials for parsing matrix physicochemical control of cell migration. Integr Biol. Accepted. 2011 Kim HD*, Hause RJ*, Leung K*, Jones RA. Targeted protein-omic methods are bridging the gap between proteomic and hypothesis-driven protein analysis approaches. Expert Rev Proteomics. Accepted. 2011 Kim HD, Meyer AS, Wagner JP, Alford SK, Wells A, Gertler FB, Lauffenburger DA. Signaling network state predicts Twist-mediated effects on breast cell migration across diverse growth factor contexts. Mol Cell Proteomics. Accepted. 2011 Philippar U, Roussos ET, Oser M, Yamaguchi H, Kim HD, Giampieri S, Wang Y, Goswami S, Wyckoff JB, Lauffenburger DA, Sahai E, Condeelis JS, Gertler FB. A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev ...
Cell migration & Invasion Assays are important investigate for different cell types and disease states. Read more in this Article.
Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells [Corrigendum] Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells [Corrigendum]Ye T, Su J, Huang C, et al. OncoTargets Ther. 2016;9:7481â 7492.The authors have advised that a number of errors were made in some of the figures within their paper.Read the original article
OGT-2115 is a heparanase inhibitor (IC50 = 0.4 μM). Heparanase inhibitors suppress breast cancer cell invasion and migration induced by ER stress, and provide a strong rationale for the development of heparanase-based therapeutics for the prevention of metastasis induced by chemotherapeutic reagents.
EXTERNAL SPEAKER. Dr Sara Rossana Zanivan, Senior Lecturer, Beatson Institute for Cancer Research, University of Glasgow. Pro-invasive tumour-stroma interactions:thekey role of cancer associated fibroblasts. Hosted in room C1071 C Floor South Block Queens Medical Centre and dual broadcast to The Staff Room Academic Oncology 1st Floor above South Entrance City Hospital. This forms part of the Division of Cancer & Stem Cells seminar series ...
Research Topics, Genomes and Genes, Species, Research Grants, Publications about Control of lung cancer invasion and metastasis by vimentin
Effect of TGFβ1 on the phenotype, migratory ability, and survival of CD16− monocytes. PBMCs were depleted of CD16+ cells using miniMACS magnetic selection. T
CONCLUSIONS: The circular RNA hsa_circ_0091017 can inhibit the proliferation, migration and invasiveness of BCa cells by regulating the expression of microRNA-589-5p. PMID: 31957821 [PubMed - in process]...
Invasion was calculated employing BioCoat MatriGel Invasion Chambers (BD Biosciences) in accordance to the manufacturers recommendations. The upper insert
Human bodies are highly fluctuating complex systems. They detect and integrate the clues from changing environments and their own internal states, making numerous responses after delicate computation and regulation. Traditional routes of drug administration includes oral intake or intravenous injection may be too simplified to promptly fit the real-time condition of the body states. In addition, the frequent and repetitive intake of drugs may be annoying, and sometimes the invasive processes are suffering, bringing inconvenience to our daily lives. Medical instruments or electrical monitors can instantaneously detect and response to some specific physiological or pathological parameters, but they are usually too heavy and bulky to carry, which restrict the mobility of patients while using it. Therefore we aim to program the intestinal microbes to build our novel smart drug delivery systems-PEPDEX. There are around \(10^{13}\) to \(10^{14}\) microorganisms inhabiting in our gastrointestinal ...
Human bodies are highly fluctuating complex systems. They detect and integrate the clues from changing environments and their own internal states, making numerous responses after delicate computation and regulation. Traditional routes of drug administration includes oral intake or intravenous injection may be too simplified to promptly fit the real-time condition of the body states. In addition, the frequent and repetitive intake of drugs may be annoying, and sometimes the invasive processes are suffering, bringing inconvenience to our daily lives. Medical instruments or electrical monitors can instantaneously detect and response to some specific physiological or pathological parameters, but they are usually too heavy and bulky to carry, which restrict the mobility of patients while using it. Therefore we aim to program the intestinal microbes to build our novel smart drug delivery systems-PEPDEX. There are around \(10^{13}\) to \(10^{14}\) microorganisms inhabiting in our gastrointestinal ...
Most noticeable on CEATEC Japan for those of us who dont live in Japan was a host of robotic and sensor products programmed to talk, think, and behave like Japanese people, mirroring Japanese sensibilities, preferences, and habits.
Ent survival. However, tumor invasion and metastasis contribute to the great majority of breast Tubastatin A supplier cancer deaths. Our efforts towards the
The KOMP Repository Collection is located at the MMRRC at the University of California, Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
BioTek 應用報告, 10/09 2014, Automated Kinetic Imaging of Cell Migration and Invasion Assays using Corning FluoroBlok Permeable Supports
BioTek 应用手册, 10/09 2014, Automated, Kinetic Imaging of Cell Migration and Invasion Assays using Corning FluoroBlok™ Permeable Supports
Its the zombie-slaying survival game with JRPG elements you didnt know you wanted! Get swarmed by zombies in active-time battles, search for other survivors, eat and most importantly: SURVIVE!
Invasion of the Bunny Snatchers: The Return is a 1995 short subject which is directed by Greg Ford, Terry Lennon and Martin Gates. This is a Sequel to Invasion of the Bunny Snatchers.
Disease of cellular proliferation characterized by uncontrolled cellular proliferation, local tissue invasion, and disseminated metastasis
The resected size and shape can be controlled, en bloc resection is possible even in a large neoplasm, and neoplasms with ... Either polypectomy or endoscopic mucosal resection (EMR) is beneficial for patients because of its low level of invasiveness. ... So this technique can be applied to the resection of complex neoplasms such as large neoplasms, ulcerative non-lifting ... especially for large or ulcerative neoplasms. Recently, the ESD technique is applied to esophageal or colorectal neoplasms in ...
... resulting in a cellularly diverse neoplasm. This new diversity has been observed to increase the invasiveness of the tumor, ...
... neoplasm invasiveness MeSH C23.550.727.645.500 - leukemic infiltration MeSH C23.550.727.650 - neoplasm metastasis MeSH C23.550. ... neoplasm seeding MeSH C23.550.727.650.895 - neoplasms, unknown primary MeSH C23.550.727.655 - neoplasm recurrence, local MeSH ... C23.550.727.670 - neoplasm regression, spontaneous MeSH C23.550.727.700 - neoplasm, residual MeSH C23.550.737.500 - retrograde ... 727.650.560 - lymphatic metastasis MeSH C23.550.727.650.645 - neoplasm circulating cells MeSH C23.550.727.650.830 - ...
Invasion or invasiveness is the spatial expansion of the tumor through uncontrolled mitosis, in the sense that the neoplasm ... Neoplasms will often show as differently colored masses (also referred to as processes) in CT or MRI results.[citation needed] ... More generally a neoplasm may cause release of metabolic end products (e.g., free radicals, altered electrolytes, ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ...
Lung cancer is an extremely heterogeneous family of malignant neoplasms, with well over 50 different histological variants ... invasiveness, and metastasis characteristic of malignant tumors. The increased differential activity usually results in fewer ...
The neoplasms are often associated with the presence of unerupted teeth, displacement of adjacent teeth and resorption of roots ... There is also some research suggesting that α5β1 integrin may participate in the local invasiveness of ameloblastomas. People ... Smaller mandibular neoplasms have been enucleated where the cavity of the tumour is curetted, allowing preservation of the bone ... Thus, surgery is the most common treatment of this neoplasm. A case of giant ameloblastoma was recently reported and managed ...
... may occur around a neoplasm, causing dense fibrosis around the tumor, or scar tissue (adhesions) within the abdomen ... the cancer cells secrete matrix degrading enzymes to destroy normal tissue ECM thereby promoting growth and invasiveness of the ... Desmoplasia is usually only associated with malignant neoplasms, which can evoke a fibrotic response invading healthy tissue. ... not all scars are associated with malignant neoplasms. Mature scars are usually thick, collagenous bundles arranged ...
There are a few different treatment options, ranging in levels of invasiveness. Certain drugs such as oral analgesics or anti- ... and neoplasm. The primary care physician may diagnose and manage benign causes of scrotal masses such as hydrocele, varicocele ...
Lobular and Medullary Neoplasms (8550-8559) Acinar cell neoplasms (8560-8580) Complex epithelial neoplasms The term carcinoma ... local invasiveness); the ability to spread to other sites within the body (metastasize) by penetrating or entering into the ... Adnexal and Skin appendage Neoplasms (8430-8439) Mucoepidermoid Neoplasms (8440-8490) Cystic, Mucinous and Serous Neoplasms ( ... 8010-8045) Epithelial neoplasms, NOS (8050-8080) Squamous cell neoplasms (M8070/3) Squamous cell carcinoma, NOS (8090-8110) ...
A mammary tumor is a neoplasm originating in the mammary gland. It is a common finding in older female dogs and cats that are ... Biopsy will give type and invasiveness of the tumor. In addition, newer studies showed that certain gene expression patterns ... Benjamin S, Lee A, Saunders W (1999). "Classification and behavior of canine mammary epithelial neoplasms based on life-span ...
... is expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. ... 1 February 2013). "A Broad Survey of Cathepsin K Immunoreactivity in Human Neoplasms". American Journal of Clinical Pathology. ...
It is suggested that the presence of these fusion genes indicates that SEC is a true neoplasm. Unicameral bone cysts are found ... depending on the invasiveness of the cyst, it can cause a pathological fracture or even destroy the epiphyseal plate leading to ...
G1 and G2 neuroendocrine neoplasms are called neuroendocrine tumors (NETs) - formerly called carcinoid tumours. G3 neoplasms ... Several issues help define appropriate treatment of a neuroendocrine tumor, including its location, invasiveness, hormone ... Although there are many kinds of NETs, they are treated as a group of tissue because the cells of these neoplasms share common ... Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. They most ...
Shea, Christopher R.; Reed, Jon A.; Prieto, Victor G. (2014-11-03). Pathology of Challenging Melanocytic Neoplasms: Diagnosis ... This second biopsy will determine the depth and invasiveness of the melanoma, and will help to define what the final treatment ...
Proponents of saliva testing cite its ease of collection, safety, non-invasiveness, affordability, accuracy, and capacity to ... and neoplasms. The following conditions are among those that can be detected through saliva testing (list not comprehensive): ... benign and metastatic neoplasms (such as breast cancer, pancreatic cancer, and oral cancer), infectious conditions (such as HIV ...
Other neoplasms (or sources of inflammation) should therefore be considered in known or suspected LAM cases in which FDG-PET ... Increased LAM cell migration and invasiveness is rescued by TSC2 re-expression. The cellular and molecular mechanisms of ...
... without which muscle invasiveness cannot be determined), then a second TURBT is strongly recommended. Moreover, nearly half of ... neoplasms of the urinary bladder. Bladder Consensus Conference Committee". The American Journal of Surgical Pathology. 22 (12 ... Papillary lesions Urothelial Papilloma Papillary urothelial neoplasm of low malignant potential (PUNLMP) Low Grade High Grade ...
Such mutations and epigenetic alterations can give rise to cancer (see malignant neoplasms).[verification needed] Investigation ... "Promoter hypermethylation of tumor suppressor genes correlates with tumor grade and invasiveness in patients with urothelial ...
This lymphoma also belongs to a group of lymphoid neoplasms with plasmablastic differentiation that involve malignant ... binds with P53 to inhibit cell death and interacts with beta-catenin to promote the tissue-invasiveness of cancer cells; and 6 ... List of hematologic conditions Chen BJ, Chuang SS (March 2020). "Lymphoid Neoplasms With Plasmablastic Differentiation: A ... "Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the ...
Aoyama A, Chen WT (November 1990). "A 170-kDa membrane-bound protease is associated with the expression of invasiveness by ... in cervical carcinoma and cervical intraepithelial neoplasm". Anticancer Research. 23 (4): 3195-8. PMID 12926053. Iwasa S, Jin ... "A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells". Cancer ...
... in cancers is characterized by anaplasia, invasiveness, and metastasis. Malignant tumors are also characterized by ... Uses of "malignant" in oncology include: Malignancy, malignant neoplasm and malignant tumor are synonymous with cancer ...
They are also involved in cancer stem cell coordination and disease invasiveness and metastasis. Hhat inhibitors (such as RU- ... a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study ...
CT scans, FDG-positron emission tomography, and magnetic resonance imaging to detect 1) the shape and local invasiveness of ... "Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation". ... "Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on ... List of cutaneous conditions Dermal cylindroma Trichoepithelioma CYLD cutaneous syndrome List of cutaneous neoplasms associated ...
... signaling that enhances cancer cell motility and invasiveness". Cancer Cell 2005, 7(6):521-32. Ripka S, Neesse A, Riedel J, Bug ... "Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression". Blood 2011, 118:167-76. ... of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms ...
... an alternative explanation for increased invasiveness of IDH1 mutant gliomas". Neuro-Oncology. 16 (12): 1669-70. doi:10.1093/ ... "A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option". ...
... poorly differentiated neoplasm, i.e. an abnormal growth of cells that have an unclear identity and/or cell of origin. WHO ... tumors deemed highly aggressive based on their pathology and/or local invasiveness, inoperable tumors, and resections that did ...
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Neoplasm Invasiveness. en_US. dc.subject.mesh. Early Detection of Cancer. en_US. ...
Neoplasm Invasiveness * Phenotype * Receptor, PAR-1 / metabolism * Signal Transduction * Syndecan-2 / genetics ...
MRI is increasingly being used in determining the extent of local invasiveness of urethral neoplasms for accurate staging and ...
Neoplasm Invasiveness 1 0 Stomach Neoplasms 1 0 Note: The number of publications displayed in this table will differ from the ...
Neoplasm Invasiveness, Vimentin ...
Neoplasm invasiveness. * Utility of minimally invasive surgery in endometrial cancer care. * Feasibility and perioperative ...
Breast Neoplasms, Carcinoma, Lobular, Female, Humans, Magnetic Resonance Imaging, Neoplasm Invasiveness. © 2022 University of ...
Astrocytomas comprise a wide range of neoplasms that differ in their extent of invasiveness, morphological features, tendency ... BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel ... These tumors are the principle CNS neoplasm of neurofibromatosis type 1 (NF1). ...
N2 - Object: Malignant gliomas are incurable, primary brain neoplasms noted for their potential to extensively invade brain ... Our goal was to apply a mathematical modeling approach to estimate the overall tumor invasiveness on a patient-by-patient basis ... Our goal was to apply a mathematical modeling approach to estimate the overall tumor invasiveness on a patient-by-patient basis ... Our goal was to apply a mathematical modeling approach to estimate the overall tumor invasiveness on a patient-by-patient basis ...
As seen in this example, neoplasm size, contour, degree of invasiveness and tissue density can be accurately evaluated by ... to provide further information on neoplasm size and/or degree of invasiveness. ... Invasiveness and tissue architecture cannot be assessed.. Ultrasound evaluations of small soft tissue masses occurring along ...
Colorectal Neoplasms. Wang R, Chen Y-S, Dashwood W-M, Li Q, Löhr CV, Fischer K, Ho E, Williams DE, Dashwood RH. 2017. Divergent ... roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin ...
The authors of the concept of neoplasm chemoprevention are L.W. Wattenberg and M.B. Sporn. Their studies made in the 1960s and ... Genistein also proved to inhibit the invasiveness of tumour cells. This effect was due to the inhibition of expression of c- ... The presence of premalignant condition does not imply that a neoplasm will develop for sure; it only results in increased risk ... EGRF overexpression was confirmed in numerous types of neoplasms, also in more than 80% of HNSCC. This resulted in searching ...
Neoplasms [C04] * Neoplasms by Histologic Type [C04.557] * Neoplasms, Glandular and Epithelial [C04.557.470] * Neoplasms, ... The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. ... Neoplasms [C04] * Neoplasms by Histologic Type [C04.557] * Neoplasms, Glandular and Epithelial [C04.557.470] * Carcinoma [ ... coordinate with precoordinated organ/neoplasm term. Scope Note. A malignant neoplasm derived from glandular epithelium, in ...
Neoplasm Invasiveness. H. Y. Chang, Sneddon, J. B., Alizadeh, A. A., Sood, R., West, R. B., Montgomery, K., Chi, J. - T., van ... Neoplasms. H. Y. Chang, Sneddon, J. B., Alizadeh, A. A., Sood, R., West, R. B., Montgomery, K., Chi, J. - T., van de Rijn, M., ...
Neoplasm invasiveness, Neoplasm metastasis, Prognosis, Prostatic neoplasms, Review, Tumor markers", ...
Neoplasm Invasiveness - Preferred Concept UI. M0014576. Scope note. Ability of neoplasms to infiltrate and actively destroy ... Ability of neoplasms to infiltrate and actively destroy surrounding tissue.. Annotation:. IM general only or for invasive ... process; coordinate NIM with specific neoplasm terms / pathol (IM). Allowable Qualifiers:. DG diagnostic imaging. DI diagnosis ... Invasion, Neoplasm. Invasiveness, Neoplasm. Neoplasm Invasion. Tree number(s):. C04.697.645. C23.550.727.645. ...
Neoplasm Invasiveness. en_US. dc.subject.mesh. Neoplasm Recurrence, Local --pathology. en_US. ...
The mechanisms whereby MMP-9 expression influences tumor recurrence and invasiveness, and its association with angiogenesis, ... Adenoma, Carcinoma, Humans, Immunohistochemistry, Matrix Metalloproteinase 9, Neoplasm Invasiveness, Neoplasm Recurrence, Local ... The mechanisms whereby MMP-9 expression influences tumor recurrence and invasiveness, and its association with angiogenesis, ...
Invasiveness; Shear devices; Vinculin, Diseases, actin; vinculin, animal; cell adhesion; metabolism; mouse; neoplasm; NIH 3T3 ... These correlations in adhesion strengths and traction stresses with cell invasiveness may be useful in cancer diagnostics and ... Cell adhesion strength and tractions are mechano-diagnostic features of cellular invasiveness ... Cell adhesion strength and tractions are mechano-diagnostic features of cellular invasiveness. In: Soft Matter, 18 (23). pp. ...
Table 2 Sperm protein 17 expression frequencies in different histological subtypes of primary nervous system neoplasms. The ... invasiveness, tendency to progression and recurrence, and response to treatments [1-4]. Their still highly unfavourable ... Immunohistochemistry of Sp17 in nervous system neoplasms: a-c. glioblastomas; d. astrocytoma; e. meningioma; f. ependimoma. In ... Brain and other nervous system (NS) tumours are a group of neoplasms that vary in terms of their site of origin, morphological ...
MALAT1 promoted invasiveness of gastric adenocarcinoma. Na Keum Lee, Jung Hwa Lee, Cristina Ivan, Hui Ling, Xinna Zhang, Chan ... Dive into the research topics of MALAT1 promoted invasiveness of gastric adenocarcinoma. Together they form a unique ...
"Neoplasm Invasiveness", "type": "DefinedTerm" }, { "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", "name": "Polymorphism, ... ": "Urinary Bladder Neoplasms", "type": "DefinedTerm" } ], "author": [ { "affiliation": { "alternateName": "USC Norris ... ": "DNA, Neoplasm", "type": "DefinedTerm" }, { "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", "name": "ErbB Receptors", " ...
Neoplasm Invasiveness; Paxillin/*metabolism; Phosphorylation. ... Neoplasm Transplantation; Organ Size/drug effects; Osteoblasts/ ... MDA-MB-231-luc2-tdtomato, IVIS, tdtomato, fluorescent protein, Animals; Breast Neoplasms/enzymology/*metabolism/*pathology; ... MDA-MB-231-D3H2Ln, IVIS, Bioluminescence, Activins/*metabolism; Animals; Bone Neoplasms/*complications/pathology/ ... Neoplasm Metastasis; Solubility/drug effects; Subcellular Fractions/drug effects/metabolism; Tryptophan/*analogs & derivatives/ ...
  • The majority of cases (90%) of primary tracheal neoplasms in adults are malignant and among these 75% are represented by epithelial histotypes (mainly squamous cell carcinoma and adenoid cystic carcinoma) [ 3 , 4 ]. (imedpub.com)
  • The mechanisms whereby MMP-9 expression influences tumor recurrence and invasiveness, and its association with angiogenesis, remains to be elucidated. (ox.ac.uk)
  • Object: Malignant gliomas are incurable, primary brain neoplasms noted for their potential to extensively invade brain parenchyma. (elsevier.com)
  • The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. (nih.gov)
  • These tumors are the principle CNS neoplasm of neurofibromatosis type 1 (NF1) . (medscape.com)
  • Thymic neuroendocrine neoplasms (Th-NENs) are extremely rare, with an age-adjusted annual incidence of 0.02 per 100,000 US population, and account for approximately 5% of thymic tumors and 0.4% of all neuroendocrine neoplasms ( 1 , 2 ). (amegroups.com)
  • Pleomorphic adenoma (PA) is the most commonly found neoplasm amongst tumors of the major and minor salivary glands, originally called a mixed benign tumor in 1866 3-5 . (bvsalud.org)
  • Tracheal tumors are rare neoplasms with extremely heterogeneous histological aspects and can be potentially life-threatening, due to airway obstruction. (imedpub.com)
  • Tracheal tumors are extremely rare, representing less than 0.2% of all neoplasms of the respiratory system [ 1 ]. (imedpub.com)
  • As concerns nonepithelial tracheal neoplasms, the distinction between benign and malignant forms is generally less evident than epithelial tumors [ 5 ], due to difficulties in histological classification of these rare tumors, thus hiding a potential malignant behavior. (imedpub.com)
  • In agreement with other Authors, we believe that some tracheal tumors, even if benign, for their characteristics of invasiveness and recurrency, should always be considered as potentially malignant and thus require a more aggressive treatment [ 2 , 4 ]. (imedpub.com)
  • Gastrointestinal stromal tumors formerly classified as either leiomyomas or leiomyosarcomas account for 2% of gastric neoplasms (see Gastric Stromal Tumors ). (medscape.com)
  • The distinction between benign and malignant neoplasms is usually based on morphological aspects, biological behavior, local invasiveness and metastatic spread. (imedpub.com)
  • A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (nih.gov)
  • Astrocytomas comprise a wide range of neoplasms that differ in their extent of invasiveness, morphological features, tendency for progression, and clinical course. (medscape.com)
  • MRI is increasingly being used in determining the extent of local invasiveness of urethral neoplasms for accurate staging and preoperative planning. (medscape.com)
  • The diagnosis of thymomas entails histological classification (cytological components), assessing the malignant potential (cytologic grade and invasiveness), and TNM staging. (cap.org)
  • Pancreatic endocrine tumours (PETs) are rare and heterogeneous neoplasms, often diagnosed at metastatic stage, for which no cure is currently available. (elsevier.com)
  • STAT5b confers gemcitabine chemoresistance and promotes cell adherence and invasiveness in pancreatic cancer cells. (cusabio.com)
  • A very rare malignant epithelial neoplasm of the pancreas composed of cystic structures lined by glycogen-rich clear cells, associated with local invasiveness often involving the spleen, duodenum and/or stomach and metastatic spread to the liver, peritoneum and/or lymph nodes. (cdc.gov)
  • Pleomorphic adenoma is the most common neoplasm in major and minor salivary glands. (bvsalud.org)
  • The diversity of histological aspects displayed by neoplasms of the salivary glands causes great difficulty in terms of universal classification 1-2 . (bvsalud.org)
  • Our findings provide new insight into the role of miR-34c in the prostate, exhibiting tumor suppressing effects on proliferation, apoptosis and invasiveness. (ox.ac.uk)
  • Methods: In 243 patients presenting with contrast-enhancing gliomas, estimates of the relative invasiveness of each patient's tumor, in terms of the ratio of net proliferation rate of the glioma cells to their net dispersal rate, were derived by applying a patient-specific mathematical model to routine pretreatment MR imaging. (elsevier.com)
  • Recently, activation of two pathways that support proliferation and invasiveness of cancer cells, the Src family kinase (SFK) and mammalian target of rapamycin (mTOR) pathways, was demonstrated in PETs. (elsevier.com)
  • Lung tumor burden (visualized by bioluminescence imaging) was attenuated by D2O, and inhibition of invasiveness was also confirmed in an in vitro Matrigel transwell invasion assay. (cdc.gov)
  • The expression frequencies of many CT antigens have been determined in a variety of neoplasms [ 11 ], but little is known about their expression in human NS tumours. (biomedcentral.com)
  • The sensitivity and specificity of the various modalities, such as survey radiography, ultrasonography (US) and X-ray computed tomography (CT) vary, and therefore, their abilities to distinguish tumor size, margins, and invasiveness differ. (veterinarypracticenews.com)
  • The effect of varying degrees of extent of resection on overall survival was assessed for cohorts of patients grouped by tumor invasiveness. (elsevier.com)
  • Conclusions: These results suggest that our patient-specific, model-based estimates of tumor invasiveness have clinical utility in surgical decision making. (elsevier.com)
  • Even if rare, tracheal neoplasms can be potentially lifethreatening, due to the involvement of the airway which may cause acute asphyctic syndromes, requiring a prompt diagnosis and correct treatment (endoscopic and/or surgical) in order to restore a normal air flow. (imedpub.com)
  • Thymic neuroendocrine neoplasms (Th-NENs) are extremely rare. (amegroups.com)
  • Thymic neoplasms account for less than 1% of all malignancies with an incidence of approximately 1-5 per million. (cap.org)
  • Our goal was to apply a mathematical modeling approach to estimate the overall tumor invasiveness on a patient-by-patient basis and determine whether gross total resection would improve survival in patients with relatively less invasive gliomas. (elsevier.com)
  • Quantification of relative invasiveness assessed from routinely obtained pre-operative imaging provides a practical predictor of the benefit of gross total resection. (elsevier.com)
  • Conclusions: Although our predetermined criterion for specificity was not statistically confirmed, radiological diagnosis of noninvasive lung cancer with a thin-section computed tomography scan corresponded well with pathological invasiveness. (elsevier.com)
  • Lysyl oxidase-like 2 (LOXL2) is associated with invasiveness and metastasis in breast cancer. (yonsei.ac.kr)
  • Loss of E-cadherin, which is caused by several tumor-promoting factors, is associated with metastasis and poor prognosis in many neoplasms. (elsevier.com)
  • Neoplasm Metastasis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • This graph shows the total number of publications written about "Neoplasm Metastasis" by people in this website by year, and whether "Neoplasm Metastasis" was a major or minor topic of these publications. (uchicago.edu)
  • Below are the most recent publications written about "Neoplasm Metastasis" by people in Profiles. (uchicago.edu)
  • 15. [X-ray diagnosis of the invasiveness of colorectal neoplasms]. (nih.gov)
  • 7. [Arteriography of both mesenteric arteries in diagnosis of colonic neoplasms]. (nih.gov)
  • Reported percentages of sarcoid among skin diseases and skin neoplasms vary from 13% to 90% and 8% to 38% when considering ocular neoplasms. (intechopen.com)
  • The MWCNTs proved to guarantee the appropriate spatial arrangement of the mimetic allowing a stronger inhibition of migration and invasiveness of human melanoma (A375) cells compared to other multivalent constructs reported before. (cnrs.fr)
  • PDGF-C enhances human melanoma invasiveness through activation of neuropilin-1, a co-receptor for VEGF receptors and contribute to a metastatic phenotype [2] . (hapres.com)
  • In squamous cell carcinomas the differentiation phenotype seems to be influenced by the cell of origin and the kind of driver mutation, both responsible for the invasiveness and aggressiveness of the tumor (37, 38). (ourworldisblue.com)
  • [ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. (medscape.com)
  • Thus, the small intestine is remarkably resistant to the development of benign or malignant neoplasms, particularly when compared to the high incidence rates of adenocarcinoma of the colon. (aacrjournals.org)
  • There is no available data to estimate the incidence of this neoplasm in México. (amegroups.com)
  • Pleomorphic adenoma is the most common neoplasm in major and minor salivary glands. (bvsalud.org)
  • Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands. (medscape.com)
  • The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the table below. (medscape.com)
  • Common parotid neoplasms. (medscape.com)
  • YUHSpace: LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients. (yonsei.ac.kr)
  • These clinical and preclinical data confirm that higher LOXL2 expression is associated with invasiveness of basal-like breast cancer cells and lower survival of breast cancer patients. (yonsei.ac.kr)
  • mh:'Breast Neoplasms' OR (tw:(Mama* OR seio* OR breast* OR mamma* OR seno*) AND tw:(neopl. (bvsalud.org)
  • INTRODUCTION: Breast cancer is the most frequent neoplasm among women, representing 24.5% of all types of cancer in this population. (bvsalud.org)
  • Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. (medscape.com)
  • Among salivary gland neoplasms, 80% arise in the parotid glands, 10-15% arise in the submandibular glands, and the remainder arise in the sublingual and minor salivary glands. (medscape.com)
  • The diversity of histological aspects displayed by neoplasms of the salivary glands causes great difficulty in terms of universal classification 1-2 . (bvsalud.org)
  • Of the described mechanisms, only reduced E-cadherin/catenin expression and overexpression of hst gene seem to be relatively specific markers for prolactinoma invasiveness compared with other pituitary adenomas. (ox.ac.uk)
  • These neoplasms are biologically unusual in that they rarely metastasize outside the neuraxis yet are capable of invasion of the brain parenchyma. (nih.gov)
  • Lung tumor burden (visualized by bioluminescence imaging) was attenuated by D2O, and inhibition of invasiveness was also confirmed in an in vitro Matrigel transwell invasion assay. (cdc.gov)
  • Malignant neoplasms have features, such as excessive growth, local invasiveness, and the ability to form distant metastases (Figure 2, Table 1). (tmc.gov.in)