Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Neoplasms
Cell Movement
Neoplasms, Cystic, Mucinous, and Serous
Neoplasm Metastasis
Gene Expression Regulation, Neoplastic
Matrix Metalloproteinase 2
Immunohistochemistry
Matrix Metalloproteinase 9
Neoplasms, Multiple Primary
Tumor Cells, Cultured
Neoplasms, Second Primary
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Ovarian Neoplasms
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Carcinoma, Pancreatic Ductal
Mice, Nude
Cadherins
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Neoplasms, Experimental
Neoplasm Transplantation
Adenocarcinoma, Mucinous
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Myeloproliferative Disorders
Laminin
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Gastrointestinal Neoplasms
Cystadenoma
Neoplasm Staging
Neoplasms, Connective and Soft Tissue
Neoplasms, Plasma Cell
Reverse Transcriptase Polymerase Chain Reaction
Carcinoma, Papillary
Cell Transformation, Neoplastic
Carcinoma
Drug Combinations
RNA, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Cystadenoma, Mucinous
Blotting, Western
Urokinase-Type Plasminogen Activator
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Transfection
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Neoplasms, Vascular Tissue
Antigens, Neoplasm
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Colorectal Neoplasms
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Trophoblasts
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
Neoplasms, Radiation-Induced
Adenocarcinoma, Papillary
Testicular Neoplasms
Neoplasms, Muscle Tissue
Neoplasms, Glandular and Epithelial
Disease Progression
Collagen
Cystadenocarcinoma, Mucinous
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
Antigens, CD82
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Receptors, Urokinase Plasminogen Activator
Up-Regulation
Carcinoma, Squamous Cell
Soft Tissue Neoplasms
Hematologic Neoplasms
Dog Diseases
Neoplasms, Adnexal and Skin Appendage
Matrix Metalloproteinases
Epithelial-Mesenchymal Transition
Matrix Metalloproteinase Inhibitors
Vascular Neoplasms
Cell Division
Prognosis
Palatal Neoplasms
Down-Regulation
RNA Interference
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Cystadenocarcinoma
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Heart Neoplasms
Cystadenoma, Serous
A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)
Neovascularization, Pathologic
Neoplasm Recurrence, Local
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Phenotype
Matrix Metalloproteinase 14
A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.
Neoplasms, Germ Cell and Embryonal
Bone Marrow Neoplasms
Virulence
Vimentin
Astrocytoma
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Hepatocyte Growth Factor
Neoplasms, Adipose Tissue
Head and Neck Neoplasms
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
S100 Proteins
A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
Meningeal Neoplasms
Mice, SCID
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Introduced Species
Pituitary Neoplasms
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Mutation
Gene Expression Profiling
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Immunoenzyme Techniques
Tomography, X-Ray Computed
Proto-Oncogene Proteins c-met
Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations of the gene for PROTO-ONCOGENE PROTEINS C-MET are associated with papillary renal carcinoma and other neoplasia.
Tissue Inhibitor of Metalloproteinase-2
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.
Gene Silencing
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Extracellular Matrix
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Carcinoma, Acinar Cell
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Spinal Cord Neoplasms
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Gene Knockdown Techniques
Adenoma, Oxyphilic
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
Nervous System Neoplasms
Neoplasm Grading
Janus Kinase 2
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
Muscle Neoplasms
Hemangiosarcoma
Phosphorylation
Matrix Metalloproteinase 7
Dogs
Myelodysplastic-Myeloproliferative Diseases
Mammary Neoplasms, Experimental
Gelatinases
Peripheral Nervous System Neoplasms
Cerebral Ventricle Neoplasms
Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.
Tissue Inhibitor of Metalloproteinase-1
Pleural Neoplasms
Transcription Factors
Gene Expression
Sarcoma
Fibrosarcoma
Common Bile Duct Neoplasms
Matrix Metalloproteinases, Membrane-Associated
Mesoderm
Lymphatic Metastasis
Jaw Neoplasms
Fibroblasts
Oligonucleotide Array Sequence Analysis
Carcinogens
Transforming Growth Factor beta
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Real-Time Polymerase Chain Reaction
Cerebellar Neoplasms
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
Cells, Cultured
Cell Survival
Immunohistochemical expression of mdm2 and p21WAF1 in invasive cervical cancer: correlation with p53 protein and high risk HPV infection. (1/11529)
AIM: To investigate the immunocytochemical staining pattern of mdm2 and p21WAF1 proteins in invasive cervical cancer and to determine its relation with the expression of p53 and with the high risk HPV infection. METHODS: Immunocytochemistry for p53, mdm2, and p21WAF1 was performed in 31 paraffin embedded sections of invasive cervical cancer. The results were assessed by image analysis, evaluating for each protein the optical density of the immunostained area, scored as percentage of the total nuclear area. The presence of high risk human papillomavirus (HPV) infection was detected by using the polymerase chain reaction. RESULTS: Immunostaining for both mdm2 and p21WAF1 was correlated with p53 expression; however, the correlation between p53 and mdm2 (R = 0.49; p < 0.01) was more significant than between p53 and p21WAF1 (R = 0.31; p < 0.05); the less stringent correlation between p53 and p21WAF1 might reflect the p53 independent mechanisms of p21WAF1 induction. Similar average levels of p53, mdm2, and p21WAF1 immunostaining were found in the presence or absence of high risk HPV-DNA, without significant differences between the two groups. CONCLUSIONS: These data suggest that mdm2 and p21WAF1 proteins are expressed in invasive cervical cancer and that their immunocytochemical staining pattern is not abrogated by the presence of high risk HPV genomic sequences. (+info)The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells. (2/11529)
The acquisition of invasiveness is a crucial step in the malignant progression of cancer. In cancers of the colon and of other organs the E-cadherin/catenin complex, which is implicated in homotypic cell-cell adhesion as well as in signal transduction, serves as a powerful inhibitor of invasion. We show here that one allele of the alphaE-catenin (CTNNA1) gene is mutated in the human colon cancer cell family HCT-8, which is identical to HCT-15, DLD-1 and HRT-18. Genetic instability, due to mutations in the HMSH6 (also called GTBP) mismatch repair gene, results in the spontaneous occurrence of invasive variants, all carrying either a mutation or exon skipping in the second alphaE-catenin allele. The alphaE-catenin gene is therefore, an invasion-suppressor gene in accordance with the two-hit model of Knudsen for tumour-suppressor genes. (+info)Role of thrombin receptor in breast cancer invasiveness. (3/11529)
Invasion, the ability of an epithelial cancer cell to detach from and move through a basement membrane, is a central process in tumour metastasis. Two components of invasion are proteolysis of extracellular matrix and cellular movement through it. A potential promoter of these two processes is thrombin, the serine proteinase derived from the ubiquitous plasma protein prothrombin. Thrombin promotes the invasion of MDA-MB231 breast tumour cells (a highly aggressive cell line) in an in vitro assay. Invasion by MDA-MB436 and MCF-7 cells, less aggressive cell lines, is not promoted by thrombin. Thrombin, added to the cells, is a stimulator of cellular movement; fibroblast-conditioned medium is the chemotaxin. Thrombin-promoted invasion is inhibited by hirudin. Stimulation of invasion is a receptor-mediated process that is mimicked by a thrombin receptor-activating peptide. Thrombin has no effect on chemotaxis in vitro. Thrombin receptor is detectable on the surface of MDA-MB231 cells, but not on the other two cell lines. Introduction of oestrogen receptors into MDA-MB231 cells by transfection with pHEO had no effect on thrombin receptor expression, in the presence or absence of oestradiol. This paper demonstrates that thrombin increases invasion by the aggressive breast cancer cell line MDA-MB231 by a thrombin receptor-dependent mechanism. (+info)Expression of pyrimidine nucleoside phosphorylase mRNA plays an important role in the prognosis of patients with oesophageal cancer. (4/11529)
To clarify the significance of the expression of pyrimidine nucleoside phosphorylase (PyNPase) mRNA as a predictive factor for the prognosis of patients with oesophageal carcinoma, the PyNPase mRNA in the tumours and normal tissues from 55 resected cases of oesophageal carcinoma was examined by a reverse transcription polymerase chain reaction (RT-PCR). As a result, a positive correlation was observed between the tumour/normal (T/N) ratio of the expression of PyNPase mRNA by RT-PCR and that of the enzyme activity of PyNPase based on the findings of an enzyme linked immunosolvent assay (r = 0.594, P = 0.009). The T/N ratio of the expression of PyNPase mRNA was significantly higher in the cases with lymph vessel invasion (P = 0.013), lymph node metastasis (P = 0.0016), and an advanced stage of the disease (P = 0.021) than those without these factors. The patients with a higher T/N ratio of PyNPase mRNA showed significantly worse prognosis than those with a lower T/N ratio (P = 0.023 with log-rank tests). A multivariate analysis for the cumulative survival rates revealed that a high T/N ratio of the expression of PyNPase mRNA was independently related to a poor prognosis. These findings suggested that the determination of PyNPase mRNA by RT-PCR thus appears to be a new useful parameter for identifying both a poor prognosis and a highly malignant potential of oesophageal carcinoma. (+info)Low tumour cell proliferation at the invasive margin is associated with a poor prognosis in Dukes' stage B colorectal cancers. (5/11529)
The conflicting results about the prognostic impact of tumour cell proliferation in colorectal cancer might be explained by the heterogeneity observed within these tumours. We have investigated whether a systematic spatial heterogeneity exists between different compartments, and whether the presence of such a systematic heterogeneity has any impact on survival. Fifty-six Dukes' stage B colorectal cancers were carefully morphometrically quantified with respect to the immunohistochemical expression of the proliferative marker Ki-67 at both the luminal border and the invasive margin. The proliferative activity was significantly higher at the luminal border compared with the invasive margin (P<0.001), although the two compartments were also significantly correlated with each other. Tumours with low proliferation at the invasive margin had a significantly poorer prognosis both in univariate (P = 0.014) and in multivariate survival analyses (P = 0.042). We conclude that Dukes' B colorectal cancers exhibit a systematic spatial heterogeneity with respect to proliferation, and tumours with low proliferation at the invasive margin had a poor prognosis. The present data independently confirm recent results from the authors, and provide new insights into the understanding of tumour cell proliferation in colorectal cancer. (+info)A possible involvement of aberrant expression of the FHIT gene in the carcinogenesis of squamous cell carcinoma of the uterine cervix. (6/11529)
To investigate involvement of an aberrant expression of the FHIT (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by the reverse transcriptase polymerase chain reaction (RT-PCR) and cDNA sequence method in 32 cervical invasive carcinomas (25 squamous cell carcinomas and seven adeno- or adenosquamous carcinomas) and 18 of its precursor lesions [four low-grade and 14 high-grade cervical intraepithelial neoplasias (CINs)]. We also examined a link between the occurrence of the aberrant expression and human papillomavirus (HPV). We detected the aberrant FHIT transcripts in 11 of 25 (44%) cervical invasive squamous cell carcinomas and in 5 of 14 (36%) high-grade CINs (CIN 2 or 3), whereas they were not found in seven non-squamous type and four low-grade CINs (CIN 1). The alteration patterns of the FHIT gene expression in high-grade CINs were virtually similar to those found in invasive carcinomas, such that the exons 5-7 were consistently deleted associated or unassociated with loss of the exon 4 and/or 8. The incidence of the aberrant expression was not related to the presence of HPV and its type. These data indicate that the aberrant expression of the FHIT gene is observed in precursor lesions of cervical carcinoma as well as invasive carcinomas, with its incidence not increasing with advance of clinical stage. Given the squamous cell type dominant expression, the aberrant expression may play a critical role in the generation of squamous cell carcinoma of the uterine cervix, but not the consequence of the progression of the cancer. (+info)Enhanced tumor growth and invasiveness in vivo by a carboxyl-terminal fragment of alpha1-proteinase inhibitor generated by matrix metalloproteinases: a possible modulatory role in natural killer cytotoxicity. (7/11529)
Matrix metalloproteinases (MMPs) are believed to contribute to the complex process of cancer progression. They also exhibit an alpha1-proteinase inhibitor (alphaPI)-degrading activity generating a carboxyl-terminal fragment of approximately 5 kd (alphaPI-C). This study reports that overexpression of alphaPI-C in S2-020, a cloned subline derived from the human pancreas adenocarcinoma cell line SUIT-2, potentiates the growth capability of the cells in nude mice. After stable transfection of a vector containing a chimeric cDNA encoding a signal peptide sequence of tissue inhibitor of metalloproteinase-1 followed by cDNA for alphaPI-C into S2-020 cells, three clones that stably secrete alphaPI-C were obtained. The ectopic expression of alphaPI-C did not alter in vitro cellular growth. However, subcutaneous injection of the alphaPI-C-secreting clones resulted in tumors that were 1.5 to 3-fold larger than those of control clones with an increased tendency to invasiveness and lymph node metastasis. These effects could be a result of modulation of natural killer (NK) cell-mediated control of tumor growth in nude mice, as the growth advantage of alphaPI-C-secreting clones was not observed in NK-depleted mice, and alphaPI-C-secreting clones showed decreased NK sensitivity in vitro. In addition, production of alphaPI and generation of the cleaved form of alphaPI by MMP were observed in various human tumor cell lines and in a highly metastatic subline of SUIT-2 in vitro. These results provide experimental evidence that the alphaPI-degrading activity of MMPs may play a role in tumor progression not only via the inactivation of alphaPI but also via the generation of alphaPI-C. (+info)Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas. (8/11529)
Collagenase-3 (MMP-13) is a human matrix metalloproteinase specifically expressed by invading tumor cells in squamous cell carcinomas (SCCs) of the head and neck. Here, we have further elucidated the role of MMP-13 in tumor invasion by examining its expression in invasive malignant tumors of the female genital tract. Using in situ hybridization, expression of MMP-13 mRNA was detected in 9 of 12 vulvar SCCs, primarily in tumor cells, but not in intact vulvar epithelium, in cervical SCCs (n = 12), or in endometrial (n = 11) or ovarian adenocarcinomas (n = 8). MMP-13 expression was especially abundant in vulvar carcinomas showing metastasis to lymph nodes and was associated with expression of membrane type 1 MMP by tumor cells and gelatinase-A (MMP-2) by stromal cells, as detected by immunohistochemistry. MMP-13 mRNAs were detected in 9 of 11 cell lines established from vulvar carcinomas and in 4 of 6 cell lines from cervical carcinomas, whereas endometrial (n = 10) and ovarian (n = 9) carcinoma cell lines were negative for MMP-13 mRNA. No correlation was detected between MMP-13 expression and p53 gene mutations in vulvar SCC cell lines. However, MMP-13 expression was detected in 5 of 6 vulvar and cervical SCC cell lines harboring HPV 16 or 68 DNA. These results show that MMP-13 is specifically expressed by malignantly transformed squamous epithelial cells, including vulvar SCC cells, and appears to serve as a marker for their invasive capacity. (+info)
The proliferation rate of cells was analyzed by MTT assay - MEK Inhibitors in highly invasive breast cancer cells
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OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo. - NDM Research...
The mode and dynamics of glioblastoma cell invasion into a decellularized tissue-derived extracellular matrix-based three...
Suppression of PPARβ, and DHA treatment, inhibit NaV1.5 and NHE-1 pro-invasive activities.
| DIAL.pr - BOREAL
Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
Invasion Signal | Science Signaling
Cell Invasion Assay (Basement Membrane), 24-well, 8 μm Kit-2313 - Creative BioMart
Tumor volume and lymphovascular space invasion as a prognostic factor in early invasive adenocarcinoma of the cervix<...
Leicester Research Archive: Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: Matrix...
Aspirin and P2Y 12 inhibition attenuate platelet-induced ovarian cancer cell invasion | BMC Cancer | Full Text
Prostaglandin E2 promotes hepatocellular carcinoma cell invasion through upregulation of YB-1 protein expression. | Sigma...
Plus it
Plus it
EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1<...
In silico studies on structure prediction and inhibitory action of selected natural compounds on cell invasion protein SipB...
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion | Science Signaling
Role of CRN2 in glioblastoma cell invasion and characterization of CRN2 deficient mice - Kölner UniversitätsPublikationsServer
The Madeleine Oudin Lab | Sackler
Spying on Cancer Cell Invasion [video] | EurekAlert! Science News
Most recent papers with the keyword pancreatic cancer neural invasion | Read by QxMD
Difference between revisions of Hyung-Do Kim - OpenWetWare
Cell Migration or Invasion Assay | BMG LABTECH
corrigendum-Isoorientin induces apoptosis, decreases invasiveness, and | OTT
OGT2115 | OGT-2115 | CAS#853929-59-6 | heparanase inhibitor | MedKoo
Seminar - Pro-invasive tumour-stroma interactions:the key role of cancer associated fibroblasts - The University of Nottingham
Control of lung cancer invasion and metastasis by vimentin
Effect of TGFβ1 on the phenotype, migratory ability, a | Open-i
Cyclic RNA hsa circ 0091017 inhibits proliferation, migration and invasiveness of bladder cancer cells by binding to microRNA...
The decrease chambers were filled with DME medium made up of five% FBS as a chemoattractant | MEK Inhibitor-sgkinhibitor.com
Team:NTU-Taida/Project/Introduction - 2012.igem.org
Team:NTU-Taida/Project/Introduction - 2012.igem.org
Cobot Invasion at Japans CEATEC | EE Times
Ent survival. However, tumor invasion and metastasis contribute to the great | URAT1 inhibitor urat1inhibitor.com
SCAI (suppressor of cancer cell invasion) - KOMP (Knockout Mouse Project)
Automated, Kinetic Imaging of Cell Migration and Invasion Assays using Corning FluoroBlok™ Permeable Supports | October 9, 2014
Automated Kinetic Imaging of Cell Migration and Invasion Assays using Corning FluoroBlok Permeable Supports | October 9, 2014
Save 51% on Invasion: Brain Craving on Steam
Invasion of the Bunny Snatchers: The Return | Looney Tunes Fanon Wiki | Fandom
Cancer - Wiki | Golden
Endoscopic submucosal dissection
The resected size and shape can be controlled, en bloc resection is possible even in a large neoplasm, and neoplasms with ... Either polypectomy or endoscopic mucosal resection (EMR) is beneficial for patients because of its low level of invasiveness. ... So this technique can be applied to the resection of complex neoplasms such as large neoplasms, ulcerative non-lifting ... especially for large or ulcerative neoplasms. Recently, the ESD technique is applied to esophageal or colorectal neoplasms in ...
ZNF238
... resulting in a cellularly diverse neoplasm. This new diversity has been observed to increase the invasiveness of the tumor, ...
List of MeSH codes (C23)
... neoplasm invasiveness MeSH C23.550.727.645.500 - leukemic infiltration MeSH C23.550.727.650 - neoplasm metastasis MeSH C23.550. ... neoplasm seeding MeSH C23.550.727.650.895 - neoplasms, unknown primary MeSH C23.550.727.655 - neoplasm recurrence, local MeSH ... C23.550.727.670 - neoplasm regression, spontaneous MeSH C23.550.727.700 - neoplasm, residual MeSH C23.550.737.500 - retrograde ... 727.650.560 - lymphatic metastasis MeSH C23.550.727.650.645 - neoplasm circulating cells MeSH C23.550.727.650.830 - ...
Malignancy
... in cancers is characterized by anaplasia, invasiveness, and metastasis.[1] Malignant tumors are also characterized ... Malignancy, malignant neoplasm and malignant tumor are synonymous with cancer. *Malignant ascites ...
Cystadenocarcinoma
... is a malignant form of a cystadenoma and is a malignant neoplasm derived from glandular epithelium, in which ... The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. ...
Targeted therapy of lung cancer
Lung cancer is an extremely heterogeneous family of malignant neoplasms, with well over 50 different histological variants ... invasiveness, and metastasis characteristic of malignant tumors. The increased differential activity usually results in fewer ...
Brain tumor
Invasion or invasiveness is the spatial expansion of the tumor through uncontrolled mitosis, in the sense that the neoplasm ... Neoplasms will often show as differently colored masses (also referred to as processes) in CT or MRI results. ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... "CNS and Miscellaneous Intracranial and Intraspinal Neoplasms" (PDF). SEER Pediatric Monograph. National Cancer Institute. pp. ...
Brain tumor
Invasion or invasiveness is the spatial expansion of the tumor through uncontrolled mitosis, in the sense that the neoplasm ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... "CNS and Miscellaneous Intracranial and Intraspinal Neoplasms" (PDF). SEER Pediatric Monograph. National Cancer Institute. pp. ... More generally a neoplasm may cause release of metabolic end products (e.g., free radicals, altered electrolytes, ...
Ameloblastoma
The neoplasms are often associated with the presence of unerupted teeth, displacement of adjacent teeth and resorption of roots ... There is also some research suggesting that α5β1 integrin may participate in the local invasiveness of ameloblastomas. People ... Smaller mandibular neoplasms have been enucleated where the cavity of the tumour is curetted, allowing preservation of the bone ... V600E mutation is also seen in other malignant and benign neoplasms, which activate the MAP kinase pathway required for cell ...
Desmoplasia
... may occur around a neoplasm, causing dense fibrosis around the tumor, or scar tissue (adhesions) within the abdomen ... the cancer cells secrete matrix degrading enzymes to destroy normal tissue ECM thereby promoting growth and invasiveness of the ... Desmoplasia is usually only associated with malignant neoplasms, which can evoke a fibrosis response by invading healthy tissue ... not all scars are associated with malignant neoplasms. Mature scars are usually thick, collagenous bundles arranged ...
Malignancy
... in cancers is characterized by anaplasia, invasiveness, and metastasis. Malignant tumors are also characterized by ... Uses of "malignant" in oncology: Malignancy, malignant neoplasm and malignant tumor are synonymous with cancer Malignant ...
Mammary tumor
A mammary tumor is a neoplasm originating in the mammary gland. It is a common finding in older female dogs and cats that are ... Biopsy will give type and invasiveness of the tumor. In addition, newer studies showed that certain gene expression patterns ... Benjamin S, Lee A, Saunders W (1999). "Classification and behavior of canine mammary epithelial neoplasms based on life-span ...
Cathepsin K
... is expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. ... 1 February 2013). "A Broad Survey of Cathepsin K Immunoreactivity in Human Neoplasms". American Journal of Clinical Pathology. ...
Neuroendocrine tumor
G1 and G2 neuroendocrine neoplasms are called neuroendocrine tumors (NETs) - formerly called carcinoid tumours. G3 neoplasms ... Several issues help define appropriate treatment of a neuroendocrine tumor, including its location, invasiveness, hormone ... Although there are many kinds of NETs, they are treated as a group of tissue because the cells of these neoplasms share common ... Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. They most ...
Acral lentiginous melanoma
Shea, Christopher R.; Reed, Jon A.; Prieto, Victor G. (2014-11-03). Pathology of Challenging Melanocytic Neoplasms: Diagnosis ... This second biopsy will determine the depth and invasiveness of the melanoma, and will help to define what the final treatment ...
Saliva testing
Proponents of saliva testing cite its ease of collection, safety, non-invasiveness, affordability, accuracy, and capacity to ... and neoplasms. The following conditions are among those that can be detected through saliva testing (list not comprehensive): ... benign and metastatic neoplasms (such as breast cancer, pancreatic cancer, and oral cancer), infectious conditions (such as HIV ...
Lymphangioleiomyomatosis
Other neoplasms (or sources of inflammation) should therefore be considered in known or suspected LAM cases in which FDG-PET ... Increased LAM cell migration and invasiveness is rescued by TSC2 re-expression. The cellular and molecular mechanisms of ...
Primary effusion lymphoma
This lymphoma also belongs to a group of lymphoid neoplasms with plasmablastic differentiation that involve malignant ... binds with P53 to inhibit cell death and interacts with beta-catenin to promote the tissue-invasiveness of cancer cells; and 6 ... List of hematologic conditions Chen BJ, Chuang SS (March 2020). "Lymphoid Neoplasms With Plasmablastic Differentiation: A ... "Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the ...
Bladder cancer
... without which muscle invasiveness cannot be determined) a second TURBT is strongly recommended. Moreover, nearly half of the ... neoplasms of the urinary bladder. Bladder Consensus Conference Committee". The American Journal of Surgical Pathology. 22 (12 ... Papillary lesions Urothelial Papilloma Papillary urothelial neoplasm of low malignant potential (PUNLMP) Low Grade High Grade ...
Fibroblast activation protein, alpha
Aoyama A, Chen WT (November 1990). "A 170-kDa membrane-bound protease is associated with the expression of invasiveness by ... in cervical carcinoma and cervical intraepithelial neoplasm". Anticancer Research. 23 (4): 3195-8. PMID 12926053. Iwasa S, Jin ... "A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells". Cancer ...
Carcinoma
8560-8580) Complex epithelial neoplasms. Carcinoma In situ[edit]. The term carcinoma in situ (or CIS) is a term for cells that ... local invasiveness); ... 8090-8110) Basal cell neoplasms *(M8090/3) Basal cell carcinoma ... and imaging studies in a logical fashion to obtain information about the size of the neoplasm and the extent of its invasion ... or other notable characteristics consistent with a more highly differentiated neoplasm. ...
Epithelioid sarcoma
They are also involved in cancer stem cell coordination and disease invasiveness and metastasis. Hhat inhibitors (such as RU- ... a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study ...
CUX1
... signaling that enhances cancer cell motility and invasiveness". Cancer Cell 2005, 7(6):521-32. Ripka S, Neesse A, Riedel J, Bug ... "Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression". Blood 2011, 118:167-76. ... of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms ...
Glioblastoma
... an alternative explanation for increased invasiveness of IDH1 mutant gliomas". Neuro-Oncology. 16 (12): 1669-70. doi:10.1093/ ... "A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option". ...
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
A Jnk-Rho-Actin remodeling positive feedback network directs Src-driven invasion
RNA Therapeutics - & related info | Mendeley
Laringectomía total ampliada en carcinoma laríngeo avanzado T4a
Effects of small interfering RNA targeting heparanase-1 combined with heparin on invasiveness of mouse hepatocellular carcinoma...
Liver Neoplasms, Experimental / metabolism, pathology*. Mice. Neoplasm Invasiveness*. Neoplasm Metastasis. RNA, Messenger / ... Effects of small interfering RNA targeting heparanase-1 combined with heparin on invasiveness of mouse hepatocellular carcinoma ... invasiveness of Hca-F cells was observed by Matrigel invasion assay.. RESULTS: HPA-1 was negative in Hepa1-6 cells while ... The combined application of specific siRNA targeting HPA-1 and heparin is more effective in inhibiting the invasiveness of ...
Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells.
Endometrial Cancer | Cancer Genetics Web
Osteosarcoma | Cancer Genetics Web
POVEZANOST POJAVE PERITUMORALNIH PUKOTINA U DUKTALNOM INVAZIVNOM KARCINOMU DOJKE S MIOFIBROBLASTIČNOM REAKCIJOM STROME
CO2 Pneumoperitoneum Effects on Molecular Markers of Tumor Invasiveness in SH-SY5Y Neuroblastoma Cells
These data suggest that CO2 pneumoperitoneum might not adversely impact NB cell invasiveness; however, it is necessary to ... Recurrent Malignant Solid Neoplasm; Recurrent Medulloblastoma; Recurrent Ne uroblastoma; Recurrent Non-Hodgkin Lymphoma; ... CO2 Pneumoperitoneum Effects on Molecular Markers of Tumor Invasiveness in SH-SY5Y Neuroblastoma Cells. *. ... These data suggest that CO2 pneumoperitoneum might not adversely impact NB cell invasiveness; however, it is necessary to ...
Article abstract | Medical Science Monitor
Risk factors for recurrence of stage I/II (TNM) colorectal adenocarcinoma in patients undergoing surgery with curative intent
Key words: Neoplastic invasiveness; Adenocarcinoma; Prognosis; Colorectal neoplasms. RESUMO. OBJETIVO:. Analisar fatores de ... Patients mean age was 58.5 ± 12.6 years (24-79 years), with a slight predominance of male (53.3%). Rectal neoplasm accounted ... Currently, the biological behavior of malignant colorectal neoplasm still surpasses the ability to predict recurrence ... aggressive neoplasm.7 15 16 17 18 In this study, 29% of patients had lymphatic vascular infiltration and 12% had venous ...
Epo (erythropoietin) - Rat Genome Database
Neoplasm Invasiveness ISO. RGD:735849. 9068941. CTD Direct Evidence: marker/mechanism. CTD. PMID:16699298. ... Mammary Neoplasms, Experimental treatment. ISO. RGD:2559. 9068941. RGD. PMID:12118093, REF_RGD_ID:11041669. ... Neoplasm Metastasis ISO. RGD:735849. 9068941. CTD Direct Evidence: marker/mechanism. CTD. PMID:16699298. ... Thyroid Neoplasms ISO. RGD:735849. 9068941. CTD Direct Evidence: marker/mechanism. CTD. PMID:16699298. ...
Mir217 (microRNA 217) - Rat Genome Database
Análise da expressão plasmática e tecidual das metaloproteinases de matriz 2 e 9...
Diagnostic, clinical and therapeutic aspects of primary transitional cell carcinoma of the prostate]. - PubMed - NCBI
It is marked by local invasiveness and distant metastases. Transitional cell carcinoma has its origin at the level of the ... Transitional cell carcinoma is a rare neoplasm with an reported incidence of 2%. It is biologically different from ... The Authors report 3 new cases, discussing diagnostic, clinical and therapeutical aspects of this rare neoplasm. ...
The natural compound atraric acid is an antagonist of the human androgen receptor inhibiting cellular invasiveness and...
The natural compound atraric acid is an antagonist of the human androgen receptor inhibiting cellular invasiveness and prostate ... Prostatic Neoplasms (pathology) Join CureHunter, for free Research Interface BASIC access!. Take advantage of free CureHunter ... The natural compound atraric acid is an antagonist of the human androgen receptor inhibiting cellular invasiveness and prostate ... Analyses of cell invasion revealed that AA inhibits the invasiveness of LNCaP cells through extracellular matrix. Thus, this ...
Article abstract | Medical Science Monitor
Polo-like kinase 1 is overexpressed in renal cancer and participates in the proliferation and invasion of renal cancer cells. |...
Proliferative and Invasive Effects of Progesterone-Induced Blocking Factor in Human Glioblastoma Cells. - NextBio article
LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non-small cell lung cancer cells. - NextBio...
Cancer Glossary
Early versus deferred androgen suppression therapy for patients with lymph node-positive prostate cancer after local therapy...
Neoplasm Invasiveness/; 7: (nod* adj3 positiv*).mp.; 8: N1.mp.; 9: D1.mp.; 10: N2.mp.; 11: (lymph* adj3 (metastas* or tumo* or ... MeSH descriptor Neoplasm Invasiveness, this term only; 7: (nod* NEAR/3 positiv*); 8: (N1 OR N2 OR D1); 9: (lymph NEAR/3 ( ... 1: Prostatic Neoplasms/; 2: (prostat* adj3 (cancer* or tumo* or neoplas* or carcinom* or malign*)).tw.; 3: 1 or 2; 4: Lymph ... 1: MeSH descriptor Prostatic Neoplasms, this term only; 2: (prostat* NEAR/3 (cancer* OR tumo* OR neoplas* or carcinom* or ...
Staging Systems for Musculoskeletal Neoplasms
In the treatment of musculoskeletal neoplasms, preservation of limb function and prolongation of survival have improved over ... and their presence may be an indication of invasiveness. ... Staging Systems for Musculoskeletal Neoplasms. Henry A Finn, MD ... Musculoskeletal neoplasms infrequently metastasize to regional lymph nodes, but distant metastasis without regional lymph node ... An understanding of the approaches used for staging of musculoskeletal neoplasms requires knowledge of their biologic behavior ...
Neoplasms 1 Flashcards by Charlie Lefroy | Brainscape
Malignant neoplasm. A tumour having the properties of anaplasia, invasiveness and metastasis.. ... A benign epithelial neoplasm characterised by the formation of finger-like projections from the epithelial surface. ... A benign epithelial neoplasm that forms glands OR which derives from glandular tissue ...
VI - Neoplasia Flashcards by Yvonne Danielle Vinas | Brainscape
This is a benign epithelial neoplasm which produces glandular patterns or neoplasms derived from glands but not necessarily ... This component of tumors is crucial to the growth of neoplasms since it carries the blood supply and provides support to the ... These are benign epithelial neoplasms, growing on any surface that produce microscopic or macroscopic finger-like fronds. ... These are benign epithelial neoplasms, growing on any surface that produce microscopic or macroscopic finger-like fronds. ...
JUB is highly upregulated in colorectal cancer (CRC) sp | Open-i
MiR-139-5p inhibits CRC invasion via directly targeting | Open-i
CIC (capicua transcriptional repressor)
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Ameloblastoma is an odontogenic neoplasm with local invasiveness and high recurrence. We previously suggested that growth ... Expression of molecules related to AKT pathway as putative regulators of ameloblastoma local invasiveness. ... factors, matrix metalloproteinases (MMPs), and TIMPs influence ameloblastoma invasiveness (Pathol. Res. Pract., 208, 2012, 225 ...
MetastasisBreast NeoplasmsPathologyCarcinomaColonic NeoplasmsPapillary mucinousNeoplasticIntraductalStomach neoplasmsRecurrenceProgressionLocal invasivenessTumorsParotid neoplasmsMalignant neoplasmCellsEpithelialIntracranialSalivary gland neoplasmsPrognosis2017ColorectalMotility and invasivenessProliferationOverexpressionCystic neoplasmsStagingBenignOvarianRare neoplasmTumor Invasiveness
Metastasis6
- Application of endoscopic resection (ER) to gastrointestinal (GI) neoplasms is limited to lesions with no risk of nodal metastasis. (wikipedia.org)
- Malignancy in cancers is characterized by anaplasia , invasiveness, and metastasis . (wikipedia.org)
- discovered that exogenously expressed wt MxA inhibited the motility and invasiveness of PC3M prostate cancer cells, including hepatic metastasis [17]. (termedia.pl)
- SACC is one of the most common malignant salivary gland tumors, comprising 10% of all salivary gland neoplasms, which is characterized by PNI, strong invasiveness, and hematogenous metastasis ( 3 ). (frontiersin.org)
- GPR48 may thus play an important role in invasiveness and metastasis of carcinoma and might therefore represent a potential prognostic marker or therapeutic target. (elsevier.com)
- Expression levels of Plexin-B1 protein were significantly higher in serous ovarian carcinomas than in normal ovaries or benign ovarian neoplasms, and in the former, Plexin-B1 expression was positively correlated with lymphatic metastasis, and the membrane and cytoplasm of cancer cells stained positively. (springer.com)
Breast Neoplasms1
- Breast Neoplasms and 69 others ), proposed to participate in pathways (CARM1 and Regulation of the Estrogen Receptor, Downregulated of MTA-3 in ER-negative Breast Tumors, Pelp1 Modulation of Estrogen Receptor Activity) and processes (androgen metabolic process, antral ovarian follicle growth, epithelial cell development, epithelial cell proliferation involved in mammary gland duct elongation, male gonad development and 12 others ). (nrresource.org)
Pathology1
- We evaluated their molecular and cytogenetic alterations, identifying shared and unique abnormalities, providing evidence of a clonal relationship between these two groups of neoplasms, which traditionally represent different cellular origins.MethodsA search of the pathology database at a major referral center (Memorial Sloan-Kettering Cancer Center) was performed to identify patients diagnosed with GCT between 2012-2018, and had at least 1 prior or subsequent bone marrow biopsy. (medworm.com)
Carcinoma6
- Effects of small interfering RNA targeting heparanase-1 combined with heparin on invasiveness of mouse hepatocellular carcinoma cell lines. (biomedsearch.com)
- This study was to explore the effects of specific small interfering RNA (siRNA) targeting HPA-1 combined with heparin on invasiveness of mouse hepatocellular carcinoma cells. (biomedsearch.com)
- However, it remains unclear whether additional alterations are required for the progression of high-grade neoplasms to invasive pancreatic carcinoma. (aacrjournals.org)
- Parathyroid carcinoma is an extremely rare malignant endocrine neoplasm that is very challenging in its diagnosis as well as its treatment. (egms.de)
- Hepatocellular carcinoma (HCC) is the sixth most common neoplasm and the third most frequent cause of cancer death[ 1 ]. (biomedcentral.com)
- giant cell carcinoma a poorly differentiated, highly malignant, epithelial neoplasm containing many large multinucleated tumor cells, such as occurs in the lungs. (thefreedictionary.com)
Colonic Neoplasms1
- Colonic Neoplasms and 26 others ) and proposed to participate in processes (behavioral fear response, brain development, epithelial cell maturation involved in prostate gland development, learning or memory, negative regulation of androgen receptor signaling pathway and 13 others ). (nrresource.org)
Papillary mucinous6
- Intraductal papillary mucinous neoplasms (IPMNs) represent a group of cystic pancreatic neoplasms with large range of clinical behaviours, ranging from low-grade dysplasia or borderline lesions to invasive carcinomas. (hindawi.com)
- Intraductal papillary mucinous neoplasms (IPMNs) are a subgroup of cystic pancreatic neoplasms, representing an estimated 0.5-9.8% of all pancreatic exocrine tumours [ 1 , 2 ]. (hindawi.com)
- Only in 1997 the term intraductal papillary mucinous neoplasms (IPMN) was introduced by the WHO (Word Health Organization) [ 1 , 10 ]. (hindawi.com)
- The progression from precursor lesions of pancreatic cancer, including pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm (IPMN), to invasive disease is characterized by stepwise accumulation of genetic alterations. (aacrjournals.org)
- See Cancer , Doubling time , Intraductal papillary-mucinous neoplasm of pancreas, Metastases, Papillary & solid neoplasm of pancreas. (thefreedictionary.com)
- Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas. (semanticscholar.org)
Neoplastic2
- The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. (wikipedia.org)
- Intraductal papillary neoplasm of the bile duct (IPNB) is characterized by dilated intrahepatic bile ducts filled with papillary or villous neoplastic biliary epithelium [1]. (semanticscholar.org)
Intraductal4
- Following discussion in our multidisciplinary board meeting the patient underwent a pylorus preserving pancreatoduodenectomy, and histopathological examination revealed an ovarian‑stromal type intraductal mucinous cystic neoplasm of the extra hepatic biliary. (spandidos-publications.com)
- A previously undescribed form of intraductal papillary neoplasm of the bile duct. (semanticscholar.org)
- Not infrequently, because of its production of excess mucin, this tumor causes cystic dilation of the affected bile ducts as well as branched-type intraductal mucinous papillary neoplasm of the pancreas [2]. (semanticscholar.org)
- Non-invasive intraductal papillary neoplasms of the common bile duct: a clinicopathologic study of six cases. (semanticscholar.org)
Stomach neoplasms1
- In Japan, ESD is now gaining acceptance as the standard endoscopic resection technique for stomach neoplasms in an early stage, especially for large or ulcerative neoplasms. (wikipedia.org)
Recurrence3
- Ameloblastoma is an odontogenic neoplasm with local invasiveness and high recurrence. (jove.com)
- Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. (stanford.edu)
- Since biliary mucinous cystic neoplasms are characterized by malignant transformation and high rates of recurrence, surgical resection with negative margins is the treatment of choice for both non‑invasive and invasive biliary mucinous cystic neoplasms. (spandidos-publications.com)
Progression1
- Gliomas comprise a heterogeneous group of neoplasms that differ in location within the central nervous system, in age and sex distribution, in growth potential, in extent of invasiveness, in morphological features, in tendency for progression, and in response to treatments. (medscape.com)
Local invasiveness2
Tumors13
- This component of tumors is crucial to the growth of neoplasms since it carries the blood supply and provides support to the growth of cells. (brainscape.com)
- Our results suggest that analysis of the methylation of DNA in mucosal wash fluid may be a good molecular marker for predicting the invasiveness of colorectal tumors. (aacrjournals.org)
- Recently, narrow-band imaging magnification endoscopy has also been used to predict the invasiveness of colorectal tumors ( 11 ). (aacrjournals.org)
- As yet, there is no study describing a molecular test for predicting the invasiveness of colorectal tumors. (aacrjournals.org)
- Biliary mucinous cystic neoplasms are very rare tumors of the biliary tract with malignant potential. (spandidos-publications.com)
- 1] reported 5% of lymph node ''when defined with strict histopathologic criteria, these metastases and 1% of distant metastases in 102 patients tumors are not expected to show molecular alterations V600E with ''noninvasive follicular thyroid neoplasm with papil- associated with classic PTC, such as BRAF muta- lary-like nuclear features'' (NIFTP). (deepdyve.com)
- Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
- Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
- Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
- Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
- In tumors such as medulloblastomas, the loss of ZNF238 can disorganize the tumor's cellular divisional processes, resulting in a cellularly diverse neoplasm. (wikipedia.org)
- Of the estimated 19,000 primary brain tumors diagnosed in the United States each year, approximately 60 percent are gliomas, a heterogeneous group of neoplasms that differ in location within the central nervous system, growth potential, invasiveness and response to treatment. (memorialhermann.org)
- Several previous reports have demonstrated that Castleman's disease can mimic various tumors, for example: thymoma (1), angiofibroma (2), meningioma (8), pulmonary neoplasms (9), adnexal mass (10), and cervical mass (4). (upmc.edu)
Parotid neoplasms3
- Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands. (medscape.com)
- The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the table below. (medscape.com)
- Common parotid neoplasms. (medscape.com)
Malignant neoplasm2
- Neoplasm may be further spoken of as a malignant neoplasm or cancer. (news-medical.net)
- Cystadenocarcinoma is a malignant form of a cystadenoma and is a malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (wikipedia.org)
Cells16
- Hypoxic stimulation accelerated the invasive activity of PK8 cells, and invasiveness was thus further accelerated when the hypoxic PK8 cells were cultured with conditioned medium prepared from hypoxic MRC5 cells (hypoxic conditioned medium). (nih.gov)
- We propose that membrane-associated IL-1alpha expressed on malignant cells stimulates anti-tumour immunity, while secretable IL-1beta derived from the micro-environment or the malignant cells, activates inflammation that promotes invasiveness and induces tumour-mediated suppression. (nih.gov)
- After transfection with two specific siRNAs targeting HPA-1, siRNA-1 and siRNA-2, and treatment with heparin, invasiveness of Hca-F cells was observed by Matrigel invasion assay. (biomedsearch.com)
- CONCLUSION: The combined application of specific siRNA targeting HPA-1 and heparin is more effective in inhibiting the invasiveness of mouse hepatoma cells. (biomedsearch.com)
- Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells. (biomedsearch.com)
- Overexpression of p21SNFT led to a reduction in invasiveness of HepG2 cells through type I collagen and reconstituted basement membrane, an effect similar to that obtained via direct immunodepletion of matrix metalloproteinase-1. (biomedsearch.com)
- Analyses of cell invasion revealed that AA inhibits the invasiveness of LNCaP cells through extracellular matrix. (curehunter.com)
- Consistently, we demonstrated that stable overexpression of ROCK2 significantly enhanced cell motility and invasiveness in HCC cells. (hku.hk)
- Restoration of DUSP4 expression in pancreatic cancer cells significantly suppressed invasiveness and anoikis resistance via ERK inactivation. (aacrjournals.org)
- Colon cancer cells with elevated PLAC8 levels exhibited EMT features, including increased expression of VIM and zinc finger E-box binding homeobox 1 (ZEB1), aberrant cell motility, and increased invasiveness. (zfin.org)
- The present study was designed to determine whether tumor-associated endothelial cells (TAECs) could contribute to the invasiveness of HCC after insufficient RFA. (biomedcentral.com)
- The effects of TAECs on the invasiveness of HepG2-GFP or HCCLM3-GFP cells after insufficient RFA were analyzed. (biomedcentral.com)
- In 1990, Rosai (5) suggested that the onset of Kaposi sarcoma-like neoplasms in hyaline vascular Castleman's disease could be mediated by the production of angiogenic factors by the activated lymphoid cells. (upmc.edu)
- Title: Modification of α2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway. (nih.gov)
- Dashevsky O , Varon D, Brill A. Platelet-derived microparticles promote invasiveness of prostate cancer cells via upregulation of MMP-2 production. (harvard.edu)
- In the present study, through the establishment of highly invasive cells from pancreatic cancer and a comprehensive gene analysis, it is suggested that IL‑32 may serve an important role as a molecule involved in the invasiveness of this neoplasm. (spandidos-publications.com)
Epithelial1
- GEP-NETs are a heterogeneous group of epithelial neoplasms with neuroendocrine differentiation. (jove.com)
Intracranial1
- Pituitary adenomas (PAs) represent 10% to 25% of all intracranial neoplasms. (oncotarget.com)
Salivary gland neoplasms6
- Some common salivary gland neoplasms are listed in the table below. (medscape.com)
- [ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. (medscape.com)
- Salivary gland neoplasms most commonly appear in the sixth decade of life. (medscape.com)
- Among salivary gland neoplasms, 80% arise in the parotid glands, 10-15% arise in the submandibular glands, and the remainder arise in the sublingual and minor salivary glands. (medscape.com)
- Salivary gland neoplasms are rare in children. (medscape.com)
- In children, 35% of salivary gland neoplasms are malignant. (medscape.com)
Prognosis2
- Our purpose was to ascertain whether the levels of transcript expression of any of 20 genes under study correlated with tumor grade and clinical stage (which even in the year 2000 remain the best overall predictors of prognosis in patients with these three neoplasms). (springer.com)
- Its role in guiding the treatment of neoplasms, making diagnosis and predicting prognosis has been reported. (oncotarget.com)
20171
- Rosário, Pedro 2017-11-10 00:00:00 World J Surg (2018) 42:2277-2278 DOI 10.1007/s00268-017-4351-6 LETTE R T O T HE EDI T OR Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Did We Trade Six for a Half a Dozen? (deepdyve.com)
Colorectal2
- Using the diagnostic tree constructed by an objective algorithm, the diagnostic accuracy of the invasiveness of colorectal cancer was 91.3% for the training set and 85.1% for the test set. (aacrjournals.org)
- Recently, the ESD technique is applied to esophageal or colorectal neoplasms in some institutions, although it is still controversial considering the technical difficulty, associated risks, and favorable outcomes by EMR. (wikipedia.org)
Motility and invasiveness1
- It has long been established that IFNs decrease cancer cell proliferation, motility and invasiveness [1, 5, 6]. (termedia.pl)
Proliferation2
- They are graded histologically between 1 and 4 according to the WHO classification system of tumor cellularity, proliferation, angiogenesis, and invasiveness ( 4 ). (aacrjournals.org)
- This new diversity has been observed to increase the invasiveness of the tumor, yielding proliferation into more areas of the brain than before the loss of ZNF238. (wikipedia.org)
Overexpression1
- We suggest that survivin overexpression is potentially associated with PA invasiveness. (oncotarget.com)
Cystic neoplasms1
- Their imaging features are frequently overlapped with cystic neoplasms. (hindawi.com)
Staging1
- An understanding of the approaches used for staging of musculoskeletal neoplasms requires knowledge of their biologic behavior and natural history. (healio.com)
Benign4
- Benign neoplasm or benign tumor. (news-medical.net)
- Neoplasms may be benign or malignant. (thefreedictionary.com)
- Neoplasms show partial or complete lack of structural organization and functional coordination with the normal tissue, and usually form a distinct mass of tissue that may be either benign ( benign tumor ) or malignant ( cancer ). (thefreedictionary.com)
- Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. (medscape.com)
Ovarian2
- Circulating Levels of CSF-1 (M-CSF), a Lymphohematopoietic Cytokine, May Be a Useful Marker of Disease Status in Patients with Malignant Ovarian Neoplasms. (springer.com)
- The Macrophage Colony Stimulating Factor CSF-1, an Auto-and Paracrine Tumor Cytokine, is also a Circulating "Tumor Marker" in Patients with Ovarian, Endometrial and Pulmonary Neoplasms. (springer.com)
Rare neoplasm1
- The Authors report 3 new cases, discussing diagnostic, clinical and therapeutical aspects of this rare neoplasm. (nih.gov)
Tumor Invasiveness1
- These contrasting endoscopic technologies not only improve the visualization of early foci missed by conventional endoscopy, but also gain the insight of histopathology and tumor invasiveness, that is so-called optical biopsy. (hindawi.com)