Neomycin
Framycetin
Kanamycin Kinase
Kanamycin
Aminoglycosides
Streptomycin
Drug Resistance, Microbial
Gentamicins
Oxytetracycline
Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci. (1/850)
BACKGROUND: High-level gentamicin resistance in enterococci and staphylococci is conferred by AAC(6')-APH(2"), an enzyme with 6'-N-acetyltransferase and 2"-O-phosphotransferase activities. The presence of this enzyme in pathogenic gram-positive bacteria prevents the successful use of gentamicin C and most other aminoglycosides as therapeutic agents. RESULTS: In an effort to understand the mechanism of aminoglycoside modification, we expressed AAC(6')-APH(2") in Bacillus subtilis. The purified enzyme is monomeric with a molecular mass of 57 kDa and displays both the expected aminoglycoside N-acetyltransferase and O-phosphotransferase activities. Structure-function analysis with various aminoglycosides substrates reveals an enzyme with broad specificity in both enzymatic activities, accounting for AAC(6')-APH(2")'s dramatic negative impact on clinical aminoglycoside therapy. Both lividomycin A and paromomycin, aminoglycosides lacking a 6'-amino group, were acetylated by AAC(6')-APH(2"). The infrared spectrum of the product of paromomycin acetylation yielded a signal consistent with O-acetylation. Mass spectral and nuclear magnetic resonance analysis of the products of neomycin phosphorylation indicated that phosphoryl transfer occurred primarily at the 3'-OH of the 6-aminohexose ring A, and that some diphosphorylated material was also present with phosphates at the 3'-OH and the 3"'-OH of ring D, both unprecedented observations for this enzyme. Furthermore, the phosphorylation site of lividomycin A was determined to be the 5"-OH of the pentose ring C. CONCLUSIONS: The bifunctional AAC(6')-APH(2") has the capacity to inactivate virtually all clinically important aminoglycosides through N- and O-acetylation and phosphorylation of hydroxyl groups. The extremely broad substrate specificity of this enzyme will impact on future development of aminoglycosides and presents a significant challenge for antibiotic design. (+info)Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus. (2/850)
The Ig heavy chain (IgH) constant region (CH) genes are organized from 5' to 3' in the order Cmicro, Cdelta, Cgamma3, Cgamma1, Cgamma2b, Cgamma2a, Cepsilon, and Calpha. Expression of CH genes downstream of Cdelta involves class-switch recombination (CSR), a process that is targeted by germ-line transcription (GT) of the corresponding CH gene. Previously, we demonstrated that insertion of a PGK-neor cassette at two sites downstream of Calpha inhibits, in cultured B cells, GT of and CSR to a subset of CH genes (including Cgamma3, Cgamma2a, Cgamma2b, and Cepsilon) that lie as far as 120 kb upstream. Here we show that insertion of the PGK-neor cassette in place of sequences in the Igamma2b locus inhibits GT of and CSR to the upstream Cgamma3 gene, but has no major effect on the downstream Cgamma2a and Cepsilon genes. Moreover, replacement of the Cepsilon exons with a PGK-neor cassette in the opposite transcriptional orientation also inhibits, in culture, GT of and CSR to the upstream Cgamma3, Cgamma2b, and Cgamma2a genes. As with the PGK-neor insertions 3' of Calpha studied previously, the Cgamma1 and Calpha genes were less affected by these mutations both in culture and in mice, whereas the Cgamma2b gene appeared less affected in vivo. Our findings support the existence of a long-range 3' IgH regulatory region required for GT of and CSR to multiple CH genes and suggest that PGK-neor cassette insertion into the locus short circuits the ability of this region to facilitate GT of dependent CH genes upstream of the insertion. (+info)The role of the pseudo-disaccharide neamine as an intermediate in the biosynthesis of neomycin. (3/850)
By using wild-type and deoxystreptamine-negative mutants of Streptomyces fradiae grown in media containing [6(-3)H]glucose or [U-14C]glucose, and by subsequent hydrolysis of the labelled neomycin produced, neamines labelled with 3H in both rings I and II, but with 14C in ring I only, were prepared. A mixture of these two forms of neamine was converted by deoxystreptamine-negative Streptomyces rimosus forma paromomycinus into neomycin (not paromomycin) with a 30% yield. The3H: 14C ratio in this neomycin was the same as the measured in neamine produced by hydrolysis of the neomycin, and in unused neamine reisolated from the incubation medium. The 3H:14C ratio in the neomycin was not affected by the presence of unlabelled deoxystreptamine during the incubation. The radioactivity in the neomycin was associated with rings I and II only. It is concluded that the added neamine is incorporated into antibiotic intact, without initial hydrolysis, and that the probable first step in the subunit assembly of neomycin is the formation of neamine. (+info)A conserved sequence block in the murine and human TCR J alpha region: assessment of regulatory function in vivo. (4/850)
Temporal control of rearrangement at the TCR alpha/delta locus is crucial for development of the gamma delta and alpha beta T cell lineages. Because the TCR delta locus is embedded within the alpha locus, rearrangement of any V alpha-J alpha excises the delta locus, precluding expression of a functional gamma delta TCR. Approximately 100 kb spanning the C delta-C alpha region has been sequenced from both human and mouse, and comparison has revealed an unexpectedly high degree of conservation between the two. Of interest in terms of regulation, several highly conserved sequence blocks (> 90% over > 50 bp) were identified that did not correspond to known regulatory elements such as the TCR alpha and delta enhancers or to coding regions. One of these blocks lying between J alpha 4 and J alpha 3, which appears to be conserved in other vertebrates, has been shown to augment TCR alpha enhancer function in vitro and differentially bind factors from nuclear extracts. To further assess a plausible regulatory role for this element, we have created mice in which this conserved sequence block is either deleted or replaced with a neomycin resistance gene driven by the phosphoglycerate kinase promoter (pgk-neor). Deletion of this conserved sequence block in vivo did have a local effect on J alpha usage, echoing the in vitro data. However, its replacement with pgk-neor had a much more dramatic, long range effect, perhaps underscoring the importance of maintaining overall structure at this locus. (+info)Integrin-regulated secretion of interleukin 4: A novel pathway of mechanotransduction in human articular chondrocytes. (5/850)
Chondrocyte function is regulated partly by mechanical stimulation. Optimal mechanical stimulation maintains articular cartilage integrity, whereas abnormal mechanical stimulation results in development and progression of osteoarthritis (OA). The responses of signal transduction pathways in human articular chondrocytes (HAC) to mechanical stimuli remain unclear. Previous work has shown the involvement of integrins and integrin-associated signaling pathways in activation of plasma membrane apamin-sensitive Ca2+-activated K+ channels that results in membrane hyperpolarization of HAC after 0. 33 Hz cyclical mechanical stimulation. To further investigate mechanotransduction pathways in HAC and show that the hyperpolarization response to mechanical stimulation is a result of an integrin-dependent release of a transferable secreted factor, we used this response. Neutralizing antibodies to interleukin 4 (IL-4) and IL-4 receptor alpha inhibit mechanically induced membrane hyperpolarization and anti-IL-4 antibodies neutralize the hyperpolarizing activity of medium from mechanically stimulated cells. Antibodies to interleukin 1beta (IL-1beta) and cytokine receptors, interleukin 1 receptor type I and the common gamma chain/CD132 (gamma) have no effect on me- chanically induced membrane hyperpolarization. Chondrocytes from IL-4 knockout mice fail to show a membrane hyperpolarization response to cyclical mechanical stimulation. Mechanically induced release of the chondroprotective cytokine IL-4 from HAC with subsequent autocrine/paracrine activity is likely to be an important regulatory pathway in the maintenance of articular cartilage structure and function. Finally, dysfunction of this pathway may be implicated in OA. (+info)Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. (6/850)
Effective use of conditional Cre recombinase-loxP gene modification requires Cre-expressing mouse strains with defined patterns of expression. To assess the in vivo functionality of Cre-expressing mice, we have engineered an improved reporter strain for monitoring Cre-mediated excisions. The beta-galactosidase-neomycin phosphotransferase fusion gene (betageo)-trapped ROSA26 locus was modified by gene targeting such that betageo is expressed only after Cre-mediated excision of loxP-flanked DNA sequences. betageo from the excised ROSA26 allele is expressed ubiquitously in embryos and adult mice. By mating the reporter strain with Cre-expressing transgenic mice, we have shown that the loxP-flanked ROSA26 allele is accessible to Cre during early embryogenesis, as well as in a specific hematopoietic lineage (T lymphocytes). This improved reporter strain should facilitate monitoring in vivo Cre-mediated excision events in a variety of experimental contexts. (+info)Aluminum is a weak agonist for the calcium-sensing receptor. (7/850)
BACKGROUND: Aluminum (Al3+) has diverse biological effects mediated through activation of a putative extracellular cation-sensing receptor. A recently identified calcium-sensing receptor (CaSR), which has been identified in target tissues for Al3+, may transduce some of the biological effects of Al3+. METHODS: To test this possibility, we transfected human embryonic kidney 293 (HEK 293) cells with a cDNA encoding the rat CaSR and evaluated CaSR expression by Western blot analysis and function by measurement of intracellular calcium ([Ca2+]i) levels and inositol monophosphate (IP1) generation following stimulation with Al3+ and a panel of CaSR agonists. RESULTS: The CaSR protein was detected by immunoblot analysis in cells transfected with the CaSR cDNA but not in nontransfected HEK 293 cells. In addition, [Ca2+]i levels and IP1 generation were enhanced in a dose-dependent fashion by additions of the CaSR agonists calcium (Ca2+), magnesium (Mg2+), gadolinium (Gd3+), and neomycin only in cells transfected with CaSR. To determine if Al3+ activated CaSR, we stimulated cells transfected with rat CaSR with 10 microM to 1 mM concentrations of Al3+. Concentrations of Al3+ in the range of 10 microM to 100 microM had no effect on [Ca2+]i levels or IP1 generation. In contrast, 1 mM Al3+ induced small but significant increases in both parameters. Whereas Gd3+ antagonized calcium-mediated activation of CaSR, pretreatment with Al3+ failed to block subsequent activation of rat CaSR by Ca2+, suggesting a distinct mechanism of Al3+ action. CONCLUSION: Al3+ is not a potent agonist for CaSR. Because Al3+ affects a variety of target tissues at micromolar concentrations, it seems unlikely that CaSR mediates these cellular actions of Al3+. (+info)The supporting-cell antigen: a receptor-like protein tyrosine phosphatase expressed in the sensory epithelia of the avian inner ear. (8/850)
After noise- or drug-induced hair-cell loss, the sensory epithelia of the avian inner ear can regenerate new hair cells. Few molecular markers are available for the supporting-cell precursors of the hair cells that regenerate, and little is known about the signaling mechanisms underlying this regenerative response. Hybridoma methodology was used to obtain a monoclonal antibody (mAb) that stains the apical surface of supporting cells in the sensory epithelia of the inner ear. The mAb recognizes the supporting-cell antigen (SCA), a protein that is also found on the apical surfaces of retinal Muller cells, renal tubule cells, and intestinal brush border cells. Expression screening and molecular cloning reveal that the SCA is a novel receptor-like protein tyrosine phosphatase (RPTP), sharing similarity with human density-enhanced phosphatase, an RPTP thought to have a role in the density-dependent arrest of cell growth. In response to hair-cell damage induced by noise in vivo or hair-cell loss caused by ototoxic drug treatment in vitro, some supporting cells show a dramatic decrease in SCA expression levels on their apical surface. This decrease occurs before supporting cells are known to first enter S-phase after trauma, indicating that it may be a primary rather than a secondary response to injury. These results indicate that the SCA is a signaling molecule that may influence the potential of nonsensory supporting cells to either proliferate or differentiate into hair cells. (+info)
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Neomycin
... B is the most active component in neomycin followed by neomycin C and neomycin A. Neomycin A is an inactive ... Neomycin received approval for medical use in 1952. Rutgers University was granted the patent for neomycin in 1957. Neomycin ... Standard grade neomycin is composed of several related compounds including neomycin A (neamine), neomycin B (framycetin), ... Neomycin is a mixture of neomycin B (framycetin); and its epimer neomycin C, the latter component accounting for some 5-15% of ...
Neomycin C transaminase
... (EC 2.6.1.95, neoN (gene)) is an enzyme with systematic name 2-oxoglutarate:neomycin C aminotransferase ... Neomycin+C+transaminase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 2.6.1). ... This enzyme catalyses the following chemical reaction neomycin C + 2-oxoglutarate ⇌ {\displaystyle \rightleftharpoons } 6'''- ... "Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin". ChemBioChem. 8 (3): 283-8. doi:10.1002/cbic. ...
Allergen of the Year
2010). Neomycin Is Named Contact Allergen of the Year Archived 2015-04-22 at archive.today Sasseville, D (2010). "Neomycin". ... Neomycin (antibiotic) 2009 - Mixed dialkyl thiourea - Neoprene rubber is a common source. 2008 - Nickel 2007 - Fragrance 2006 ...
List of antibiotics
Pocket (September 1999), ISBN 0-671-02727-1. "Neomycin Drug Information". uptodate. Retrieved November 2, 2012.(subscription ...
Streptomyces brasiliensis
S. brasiliensis produces neomycin. S. brasiliensis sporulates when it is cultured with galactose and glutamic acid as carbon ...
Polymyxin B
"DailyMed - neomycin, bacitracin, polymyxin b ointment". dailymed.nlm.nih.gov. Retrieved 19 April 2019. Woo, Teri Moser; ... It is also available as the combinations bacitracin/polymyxin B and neomycin/polymyxin B/bacitracin for use on the skin. Common ...
Mycobacterium psychrotolerans
Sensitive to ciprofloxacin, gentamicin, neomycin and oxytetracycline. Differential characteristics Growth at 4°C. First ...
Busch Campus of Rutgers University
Streptomycin and neomycin, and actinomycin, were commercialized. Center for Advanced Biotechnology and Medicine (CABM) was ...
Kanamycin kinase
Antibiotics, such as the aminoglycosides kanamycin or neomycin, are added to the cultures during growth phases in order to ... This enzyme is also called neomycin-kanamycin phosphotransferase. APH(3') thermodynamically favors a dimer form of two ... neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginoa". Applied Microbiology. 16 (9): 1276-81. doi: ...
Polymyxin
"Neomycin sulfate (Cortisporin): Drug Side Effects and Dosing". MedicineNet. Retrieved 11 June 2017. Tsubery, H.; Ofek, I.; ...
Dorris J. Hutchison
Working with Waksman, Hutchison devised methods for the production and isolation of streptomycin and neomycin as anti ... Waksman, S A (1949). "Neomycin activity upon Mycobacterium tuberculosis and other mycobacteria". Am Rev Tuberc. 60 (1): 78-89. ...
Waksman Institute of Microbiology
Of these, streptomycin and neomycin, and actinomycin were commercialized. Streptomycin, in particular, was the first antibiotic ...
Nickel allergy
... neomycin, ethylenediamine, and benzocaine. Relationships between age, sex, history of exposure, and reactivity to standard ...
Streptomyces
They produce over two-thirds of the clinically useful antibiotics of natural origin (e.g., neomycin, streptomycin, cypemycin, ... Dulmage HT (March 1953). "The production of neomycin by Streptomyces fradiae in synthetic media". Applied Microbiology. 1 (2): ... Neomycin (from S. fradiae) Nourseothricin[citation needed] Puromycin (from S. alboniger) Streptomycin (from S. griseus) ...
Streptomyces isolates
Howard T. Dulmage (March 1953). "The Production of Neomycin by Streptomyces fradiae in Synthetic Media". Applied Microbiology. ... Neomycin (Streptomyces fradiae) Platensimycin (Streptomyces platensis) Puromycin (Streptomyces alboniger) Spenolimycin ( ...
Biodiversity and drugs
Streptomycin, neomycin, and erythromycin are derived from tropical soil fungi. A lot of plant species are used in today's ...
Neonatal conjunctivitis
In most countries, neomycin and chloramphenicol eye drops are used, instead. However, newborns can develop neonatal ...
Paromomycin
The in-vitro and in-vivo activities parallel those of neomycin. Almost 100% of the oral dose is eliminated unchanged via feces ... This broad-spectrum antibiotic soluble in water, is very similar in action to neomycin. Antimicrobial activity of paromomycin ...
Neamine transaminase
"Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin". ChemBioChem. 8 (3): 283-8. doi:10.1002/cbic. ... modifications in the aminoglycosides lividomycin and neomycin". Journal of Applied Microbiology. 111 (3): 642-51. doi:10.1111/j ...
6'''-Hydroxyneomycin C oxidase
H2O2 This enzyme participates in biosynthesis of aminoglycoside antibiotics of the neomycin family. Huang F, Spiteller D, ... "Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin". ChemBioChem. 8 (3): 283-8. doi:10.1002/cbic. ... modifications in the aminoglycosides lividomycin and neomycin". Journal of Applied Microbiology. 111 (3): 642-51. doi:10.1111/j ...
Paromamine 6'-oxidase
... neomycin and ribostamycin. Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB (February 2007). "Elaboration ... modifications in the aminoglycosides lividomycin and neomycin". Journal of Applied Microbiology. 111 (3): 642-51. doi:10.1111/j ... of neosamine rings in the biosynthesis of neomycin and butirosin". ChemBioChem. 8 (3): 283-8. doi:10.1002/cbic.200600371. PMID ...
Herminiimonas glaciei
Its growth is inhibited by the antibiotics gentamicin, neomycin and tetracycline. Carnobacterium pleistocenium Chryseobacterium ...
Protein synthesis inhibitor
Mehta, Roopal; Champney, W. Scott (2003). "Neomycin and Paromomycin Inhibit 30S Ribosomal Subunit Assembly in Staphylococcus ...
Cluster of Excellence Frankfurt Macromolecular Complexes
"Structure guided fluorescence labeling reveals a two-step binding mechanism of neomycin to its RNA aptamer". Nucleic Acids Res ... "Structure guided fluorescence labeling reveals a two-step binding mechanism of neomycin to its RNA aptamer". Nucleic Acids Res ... "PELDOR spectroscopy reveals preorganization of the neomycin-responsive riboswitch tertiary structure". J Am Chem Soc. 132 (5): ...
Gene expression
Protein synthesis inhibitors include the antibiotic neomycin and the toxin ricin. Post-translational modifications (PTMs) are ...
Phosphatidylinositol 4,5-bisphosphate
5-bisphosphate-interacting proteins by neomycin extraction". Mol Cell Proteomics. 10 (2): M110.003376. doi:10.1074/mcp. ...
Chinchilla
... s may be treated with chloramphenicol, neomycin, or spectinomycin for digestive problems. Sulfonamides dissolved in ...
Nystatin
... combined with neomycin sulfate and triamcinolone acetonide) Stamicin (oral tablets, Antibiotice Iaşi) Lystin Animax (veterinary ... topical ointment or cream; combined with neomycin sulfate, thiostrepton and triamcinolone acetonide) Nyata (topical powder) " ...
MON 863
MON863 contains an GM antibiotic resistance gene (nptII) against kanamycin and neomycin. Staff (8 August 2005) concerning the ...
Neamine
... (neomycin A) is a degradation product of the aminoglycoside antibiotic neomycin. Zimmermann L, Bussière A, Ouberai M, ...
Neomycin Topical: MedlinePlus Drug Information
Neomycin Topical: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Neomycin is for external use only. Do not let neomycin get into your eyes, nose, or mouth, and do not swallow it. Do not apply ... Neomycin comes in cream and ointment that is applied to the skin. Neomycin usually is used one to three times a day. Follow the ... Before using neomycin,. *tell your doctor and pharmacist if you are allergic to neomycin or any other drugs. ...
neomycin | FactMonster
neomycin nē˝ōmī´sĭn [key], broad spectrum antibiotic effective against both gram positive and gram negative bacteria (see ... Neomycin was first isolated in 1949 by the American microbiologist Selman Waksman from a strain of the bacterial species ... Neomycin is mainly used topically in the treatment of skin and mucous membrane infections, wounds, and burns. Although it is ...
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Neomycin-Bacitracin-Polymyxin Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
Find patient medical information for neomycin-bacitracin-polymyxin topical on WebMD including its uses, side effects and safety ... Neomycin-Bacitracin-Polymyxin Packet - Uses, Side Effects, and More. Generic Name(S): neomycin-bacitracin-polymyxin View Free ... List Neomycin-Bacitracin-Polymyxin Packet side effects by likelihood and severity * Who should not take Neomycin-Bacitracin- ... How to use Neomycin-Bacitracin-Polymyxin Packet This medication is for use on the skin only. Follow all directions on the ...
Casporyn (Neomycin Optic Suspension): Uses, Dosage, Side Effects, Interactions, Warning
Neomycin Optic Suspension) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related ... Neomycin sulfate is the sulfate salt of neomycin B and C, which are produced by the growth of Streptomyces fradiae Waksman (Fam ... Each mL contains: neomycin sulfate equivalent to 3.5 mg neomycin base, polymyxin B sulfate equivalent to 10,000 polymyxin B ... including neomycin. The manifestation of sensitization to neomycin is usually a low-grade reddening with swelling, dry scaling ...
Neomycin, Polymyxin B, And Hydrocortisone (Ophthalmic Route) Precautions - Mayo Clinic
Neomycin, polymyxin B, and hydrocortisone is a combination antibiotic and cortisone-like medicine. It is used to treat ... Glaucoma-Use of neomycin, polymyxin B, and hydrocortisone ophthalmic drops may make the condition worse ... Neomycin, polymyxin B, and hydrocortisone combination is available only with your doctors prescription. ... Cataract surgery, recent-Use of neomycin, polymyxin B, and hydrocortisone ophthalmic drops may delay healing or cause other ...
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... neomycin, and polymyxin B ophthalmic (ophthalmic) patient information - includes bacitracin, hydrocortisone, neomycin, and ... Bacitracin, hydrocortisone, neomycin, and polymyxin B (ophthalmic). Generic name: bacitracin, hydrocortisone, neomycin, and ... What is bacitracin, hydrocortisone, neomycin, and polymyxin B ophthalmic?. Bacitracin, hydrocortisone, neomycin, and polymyxin ... Bacitracin, hydrocortisone, neomycin, and polymyxin B may cause serious side effects. Call your doctor at once if you have: ...
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polymyxin B drug combination neomycin hydrocortisone
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PDF] The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles...
Specific deletion of each of the neo8, neo15 and neo16 genes confirmed that they are all essential for neomycin biosynthesis. ... containing aminoglycoside antibiotic neomycin. This has allowed the in vivo analysis of the respective roles of the ... glycosyltransferases Neo8 and Neo15, and of the deacetylase Neo16 in neomycin biosynthesis. ... Biosynthetic enzymes for the aminoglycosides butirosin and neomycin.. *F. Kudo, T. Eguchi ...
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Neomycin. The risk of allergy to neomycin is related directly to the extent of its use in a population. The risk of allergy to ... Certain allergens (eg, neomycin), however, penetrate intact skin poorly; in such cases, the onset of dermatitis may be delayed ... Assier-Bonnet H, Revuz J. [Topical neomycin: risks and benefits. Plea for withdrawal]. Ann Dermatol Venereol. 1997. 124(10):721 ... Assume that individuals allergic to neomycin are allergic to chemically related aminoglycoside antibiotics (eg, gentamicin, ...
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Sulfate4
- Neomycin sulfate is the sulfate salt of neomycin B and C, which are produced by the growth of Streptomyces fradiae Waksman (Fam. (rxlist.com)
- Neomycin, Polymyxin b sulfate and Hydrocortisone otic suspension (exp 4/2008) was used in my eye in error. (medschat.com)
- Active ingredient is Neomycin Sulfate 3.5mg. (mfasco.com)
- Single Antibiotic Ointment contains Neomycin Sulfate. (nickelcityinnovations.com)
Ointment4
- Neomycin comes in cream and ointment that is applied to the skin. (medlineplus.gov)
- Water-Jel Neomycin antibiotic ointment for the prevention of skin infections in cuts, scratches and minor burns. (mfasco.com)
- Clobetasol Propionate + Miconazole Nitrate + Neomycin Sulphate + Chlorocresol Ointment - This ointment is a synthesis of four medicines including Clobetasol Propionate, Miconazole Nitrate, Neomycin Sulphate, and Chlorocresol. (mestrapharma.com)
- The three active ingredients in Neosporin Antibiotic Ointment are Neomycin, Polymyxin, and Bacitracin. (northwestpharmacy.com)
Hydrocortisone11
- CASPORYN HC Optic Suspension (neomycin and polymyxin B sulfates and hydrocortisone otic suspension, USP) is a sterile antibacterial and anti-inflammatory suspension for otic use. (rxlist.com)
- Neomycin, polymyxin B, and hydrocortisone is a combination antibiotic and cortisone-like medicine. (mayoclinic.org)
- Neomycin, polymyxin B, and hydrocortisone combination is available only with your doctor's prescription. (mayoclinic.org)
- There is no specific information comparing use of ophthalmic neomycin, polymyxin B, and hydrocortisone combination in the elderly with use in other age groups. (mayoclinic.org)
- Bacitracin , hydrocortisone , neomycin , and polymyxin B ophthalmic ophthalmic (for the eyes) is a combination antibiotic and steroid medicine that is used to treat eye inflammation caused by uveitis , eye injury, radiation, chemical burns, or certain other conditions. (drugs.com)
- bacitracin , hydrocortisone , neomycin, and polymyxin B is used when there is a risk of bacterial infection in or around the eye. (drugs.com)
- Bacitracin , hydrocortisone, neomycin, and polymyxin B ophthalmic may also be used for purposes not listed in this medication guide. (drugs.com)
- You should not use this medicine if you are allergic to bacitracin, hydrocortisone, neomycin, or polymyxin B, or if you have a fungal or viral infection of the eye (including herpes). (drugs.com)
- Bacitracin, hydrocortisone, neomycin, and polymyxin B ophthalmic is not approved for use by anyone younger than 18 years old. (drugs.com)
- An overdose of bacitracin, hydrocortisone, neomycin, and polymyxin B ophthalmic is not expected to be dangerous. (drugs.com)
- Save on Neomycin-Polymyxin-Hydrocortisone at your pharmacy with the free discount below. (helprx.info)
Clobetasol Propionate2
- Clobetasol Propionate 0.05%+Neomycin 0.10%+Tolnaftate 1%+Idochlorhydroxy. (pharmahopers.com)
- Clobetasol Propionate,Neomycin Sulphate, Micona. (pharmahopers.com)
Topical1
- Free of topical antibiotics such as neomycin and bacitracin. (skinsafeproducts.com)
Drugs5
- tell your doctor and pharmacist if you are allergic to neomycin or any other drugs. (medlineplus.gov)
- What other drugs will affect neomycin? (jpeeiclinic.com)
- Other drugs may affect neomycin, including prescription and over-the-counter medicines, vitamins, and herbal products. (jpeeiclinic.com)
- Neomycin Sulphate - An antibiotic Neomycin Sulphate comes from a class of drugs called aminoglycoside that fights bacteria in the body and is used to decrease the risk of infection during certain intestinal surgeries. (mestrapharma.com)
- Regarding workers' use of drugs in a noisy environment, studies imply that persons working or living in high level noise environments may run an increased risk of auditory damage when they are on a schedule of aminoglycoside antibiotic therapy, such as neomycin (1404042) or kanamycin (8063078). (cdc.gov)
Aminoglycoside4
- An efficient protocol has been developed for the genetic manipulation of Streptomyces fradiae NCIMB 8233, which produces the 2-deoxystreptamine (2-DOS)-containing aminoglycoside antibiotic neomycin. (semanticscholar.org)
- Neomycin is an aminoglycoside antibiotic that displays bactericidal activity against gram-negative aerobic bacilli and some anaerobic bacilli where resistance has not yet arisen. (medschat.com)
- Neomycin belongs to the aminoglycoside class of antibiotics that contain two or more amino sugars connected by glycosidic bonds. (medschat.com)
- Neomycin is an aminoglycoside antibiotic which has been used for a long time in veterinary clinical practice. (antibodymall.com)
Sulphate4
- Clobetasol Propionate0.05%, Neomycin Sulphate 0. (pharmahopers.com)
- Clobetasole Propionate 0.05%, Neomycin Sulphate. (pharmahopers.com)
- With the help of our expertise, we are engaged in involved in offering Neomycin Sulphate Cream , which stops the bacteria from growing, which helps to resolve your symptoms and cure the underlying infection. (worldmedimart.com)
- Apart from this, our offered Neomycin Sulphate Cream comes in a class of medications called antibiotics. (worldmedimart.com)
Kanamycin1
- an allergic reaction to a medicine like neomycin (such as kanamycin, paromomycin , streptomycin, or gentamicin ). (drugs.com)
Antibiotics4
- A different treatment may be necessary for these types of conditions.This product contains neomycin , bacitracin , and polymyxin , antibiotics that work by stopping the growth of bacteria. (webmd.com)
- This product contains neomycin, bacitracin, and polymyxin, antibiotics that work by stopping the growth of bacteria. (blinkhealth.com)
- The antibiotics in the triple action creams is usually neomycin most times. (com.ng)
- It contains components such as neomycin, bacitracin, polymyxin, and antibiotics that work to stop bacteria's growth, leading to possible infections. (animalfate.com)
Amounts of neomycin2
- Apply only small amounts of neomycin to scrapes, cuts, burns, sores, and wounds, and do not apply it more frequently than directed. (medlineplus.gov)
- ACAM2000 is provided as a lyophilized preparation of purified live virus containing the following non-active excipients: 6-8 mM HEPES (pH 6.5-7.5), 2% human serum albumin USP, 0.5 - 0.7% sodium chloride USP, 5% mannitol USP, and trace amounts of neomycin and polymyxin B. (newstarget.com)
Infection3
- If you still have symptoms of infection after you finish the neomycin, call your doctor. (medlineplus.gov)
- Neomycin is an antibiotic that is used to prevent bacterial infection in the intestines. (jpeeiclinic.com)
- Neomycin will not treat a viral infection (flu or a common cold). (jpeeiclinic.com)
Streptomycin1
- What are the applications of streptomycin and neomycin? (yahoo.com)
Clotrimazole4
- Surfaz-SN cream is a combination of beclomethasone, clotrimazole and neomycin. (365chemists.com)
- Beclometasone is a steroid and has anti-inflammatory properties while neomycin is an antibacterial and clotrimazole is an antifungal medicine. (365chemists.com)
- If you are allergic to neomycin, clotrimazole, beclomethasone or any other ingredients of the Surfaz-SN cream. (365chemists.com)
- Usually a combination of a high or mid potency steroid like clobetasol dipropionate or betamethasone dipropionate, an antifungal like clotrimazole or ketoconazole and an antibacterial like neomycin. (com.ng)
0.0251
- Beclomethasone Dipropionate 0.025% , Neomycin S. (pharmahopers.com)
Ointments1
- We tested 259 methicillin-resistant Staphylococcus aureus isolates and 2 USA300 ATCC type strains for susceptibility to bacitracin and neomycin contained in over-the-counter antibacterial ointments. (cdc.gov)
Ampicillin1
- According to the experts, a combination treatment of ampicillin, neomycin, metronidazole and vancomycin completely inhibited hepatic neutrophil and lymphocyte infiltration in mice given the control diet. (naturalnews.com)
Bacterial2
- Neomycin is an antibiotic agent which is widely used for treating various bacterial infections of the skin. (365chemists.com)
- Against general bacterial invasion, a full dose of Neomycin can be used with a full dose of Nitrofurazone in a hospital tank. (advancedaquaticecosystems.com)
0.052
- Clobetasole 0.05% w/w , Neomycin 0.5% w/w , Mic. (pharmahopers.com)
- Clobetasol 0.05 % w/w, Neomycin 0.1 % w/w, Mico. (pharmahopers.com)
Symptoms2
- Neomycin is also used to reduce the symptoms of hepatic coma. (jpeeiclinic.com)
- Do not share neomycin with another person, even if they have the same symptoms you have. (jpeeiclinic.com)
Spectinomycin1
- Resistance levels to antimicrobials varied, but resistance was most commonly seen for spectinomycin, tetracyclines and neomycin. (cdc.gov)
Infections2
- Neomycin, an antibiotic, is used to prevent or treat skin infections caused by bacteria. (medlineplus.gov)
- Neomycin is mainly used topically in the treatment of skin and mucous membrane infections, wounds, and burns. (factmonster.com)
Resistance gene4
- IMSEAR at SEARO: Expression and stable germline transmission of neomycin-resistance gene in transgenic mice. (who.int)
- Transgenic mice were produced to study the expression of amino-3' glycosyl phosphotransferase gene (neomycin resistance gene) in the embryonic fibroblast cells. (who.int)
- A 1.9 Kb linear fragment of neomycin resistance gene under the control of pPGK promoter was microinjected into the pronucleus of mouse embryos. (who.int)
- pIRES includes a neomycin resistance gene (Neor) to aid in the selection of transfected cells. (biofeng.com)
Fradiae1
- PDF] The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase. (semanticscholar.org)
Promoter1
- Luciferase was constitutively expressed under CMV promoter, A Neomycin antibiotic marker was expressed under Rsv promoter. (gentarget.com)
Side effects2
- Neomycin may cause side effects. (medlineplus.gov)
- What is neomycin and its side effects? (jpeeiclinic.com)
Gram-positive2
- neomycin nē˝ōmī´sĭn [ key ] , broad spectrum antibiotic effective against both gram positive and gram negative bacteria (see Gram's stain ). (factmonster.com)
- Neomycin is an antibiotic found effective against gram positive and gram negative bacteria such as pseudomonas. (advancedaquaticecosystems.com)
Affinity2
- Neo-acridine was a potent inhibitor of HIV-1 Rev-Response Element (RRE) binding showing a two order of magnitude higher affinity for RRE than that of the parent neomycin B. It appears that neo-acridine is the strongest competitive inhibitor of Rev-RRE binding. (bioorganic-chemistry.com)
- This product utilizes the high affinity of monoclonal antibody against neomycin, which can identify neomycin in milk easily. (antibodymall.com)
Synthesis1
- It is composed of neomycins A, B, and C, and acts by inhibiting translation during protein synthesis. (bvsalud.org)