AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Neisseria gonorrhoeaeGonorrheaNeisseriaNeisseria meningitidisPenicillinaseSpectinomycinCefiximeNeisseria lactamicaChlamydia trachomatisUrethraUrethritisBacterial Outer Membrane ProteinsChlamydia InfectionsMicrobial Sensitivity TestsDNA, BacterialPenicillin ResistanceBacterial ProteinsCeftriaxoneFimbriae ProteinsAnti-Bacterial AgentsBacteriological TechniquesPorinsCervix UteriPenicillinsBlood Bactericidal ActivityPyocinsDrug Resistance, MicrobialFimbriae, BacterialPili, SexTransformation, BacterialCulture MediaAntigens, BacterialNeisseriaceaeMeningococcal InfectionsPenicillin GCiprofloxacinGenes, BacterialMolecular Sequence DataSexually Transmitted Diseases, BacterialNeisseria meningitidis, Serogroup BNucleic Acid Amplification TechniquesPharyngeal DiseasesTrichomonas vaginalisPelvic Inflammatory DiseaseSerotypingVaginaMeningitis, MeningococcalAnti-Infective AgentsReagent Kits, DiagnosticDrug Resistance, BacterialUterine CervicitisAgglutination TestsTetracyclineSpecimen HandlingAntibodies, BacterialBacterial AdhesionMale Urogenital DiseasesNeisseriaceae InfectionsQuinolonesNeisseria meningitidis, Serogroup W-135UrineCephalosporinsTransferrin-Binding Protein BTrichomonas InfectionsCytidine Monophosphate N-Acetylneuraminic AcidLipopolysaccharidesSpecies SpecificityBase SequenceNeisseria meningitidis, Serogroup CTetracycline ResistanceAmino Acid SequenceUrethral DiseasesTransferrin-Binding Protein APeptidoglycanSexually Transmitted DiseasesNeisseria meningitidis, Serogroup ASalpingitisTrichomonas VaginitisEvaluation Studies as TopicNeisseria meningitidis, Serogroup YMoraxellaMycoplasma genitaliumNorfloxacinPlasmidsFluoroquinolonesFemale Urogenital DiseasesCefotaximeAntigenic VariationCefuroximePolymerase Chain ReactionPenicillin G ProcaineOphthalmia NeonatorumThiamphenicolCeftizoximeLeukorrheaTransformation, GeneticPenicillin-Binding ProteinsBacterial Typing TechniquesDNA GyraseMutation
Neisseria gonorrhoeae
A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.
Gonorrhea
Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.
Neisseria
A genus of gram-negative, aerobic, coccoid bacteria whose organisms are part of the normal flora of the oropharynx, nasopharynx, and genitourinary tract. Some species are primary pathogens for humans.
Neisseria meningitidis
A species of gram-negative, aerobic BACTERIA. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the NASOPHARYNX. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis (MENINGITIS, MENINGOCOCCAL). It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype.
Penicillinase
A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.
Spectinomycin
An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
Cefixime
A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
Neisseria lactamica
A species of gram-negative, aerobic BACTERIA commonly found in the NASOPHARYNX of infants and children, but rarely pathogenic. It is the only species to produce acid from LACTOSE.
Chlamydia trachomatis
Type species of CHLAMYDIA causing a variety of ocular and urogenital diseases.
Urethra
A tube that transports URINE from the URINARY BLADDER to the outside of the body in both the sexes. It also has a reproductive function in the male by providing a passage for SPERM.
Urethritis
Inflammation involving the URETHRA. Similar to CYSTITIS, clinical symptoms range from vague discomfort to painful urination (DYSURIA), urethral discharge, or both.
Bacterial Outer Membrane Proteins
Proteins isolated from the outer membrane of Gram-negative bacteria.
Chlamydia Infections
Infections with bacteria of the genus CHLAMYDIA.
Microbial Sensitivity Tests
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
DNA, Bacterial
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Penicillin Resistance
Nonsusceptibility of an organism to the action of penicillins.
Bacterial Proteins
Proteins found in any species of bacterium.
Ceftriaxone
A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
Fimbriae Proteins
Proteins that are structural components of bacterial fimbriae (FIMBRIAE, BACTERIAL) or sex pili (PILI, SEX).
Anti-Bacterial Agents
Substances that reduce the growth or reproduction of BACTERIA.
Bacteriological Techniques
Techniques used in studying bacteria.
Porins
Porins are protein molecules that were originally found in the outer membrane of GRAM-NEGATIVE BACTERIA and that form multi-meric channels for the passive DIFFUSION of WATER; IONS; or other small molecules. Porins are present in bacterial CELL WALLS, as well as in plant, fungal, mammalian and other vertebrate CELL MEMBRANES and MITOCHONDRIAL MEMBRANES.
Cervix Uteri
The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.
Penicillins
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Blood Bactericidal Activity
The natural bactericidal property of BLOOD due to normally occurring antibacterial substances such as beta lysin, leukin, etc. This activity needs to be distinguished from the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy, which is measured by a SERUM BACTERICIDAL TEST.
Pyocins
Bacteriocins elaborated by mutant strains of Pseudomonas aeruginosa. They are protein or protein-lipopolysaccharide complexes lethal to other strains of the same or related species.
Drug Resistance, Microbial
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Fimbriae, Bacterial
Thin, hairlike appendages, 1 to 20 microns in length and often occurring in large numbers, present on the cells of gram-negative bacteria, particularly Enterobacteriaceae and Neisseria. Unlike flagella, they do not possess motility, but being protein (pilin) in nature, they possess antigenic and hemagglutinating properties. They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). Bacterial fimbriae refer to common pili, to be distinguished from the preferred use of "pili", which is confined to sex pili (PILI, SEX).
Pili, Sex
Filamentous or elongated proteinaceous structures which extend from the cell surface in gram-negative bacteria that contain certain types of conjugative plasmid. These pili are the organs associated with genetic transfer and have essential roles in conjugation. Normally, only one or a few pili occur on a given donor cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed, p675) This preferred use of "pili" refers to the sexual appendage, to be distinguished from bacterial fimbriae (FIMBRIAE, BACTERIAL), also known as common pili, which are usually concerned with adhesion.
Transformation, Bacterial
The heritable modification of the properties of a competent bacterium by naked DNA from another source. The uptake of naked DNA is a naturally occuring phenomenon in some bacteria. It is often used as a GENE TRANSFER TECHNIQUE.
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Antigens, Bacterial
Substances elaborated by bacteria that have antigenic activity.
Neisseriaceae
A family of gram-negative, parasitic bacteria including several important pathogens of man.
Meningococcal Infections
Infections with bacteria of the species NEISSERIA MENINGITIDIS.
Penicillin G
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
Ciprofloxacin
A broad-spectrum antimicrobial carboxyfluoroquinoline.
Genes, Bacterial
The functional hereditary units of BACTERIA.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Sexually Transmitted Diseases, Bacterial
Bacterial diseases transmitted or propagated by sexual conduct.
Neisseria meningitidis, Serogroup B
Strains of Neisseria meningitidis which are the most common ones causing infections or disease in infants. Serogroup B strains are isolated most frequently in sporadic cases, and are less common in outbreaks and epidemics.
Nucleic Acid Amplification Techniques
Laboratory techniques that involve the in-vitro synthesis of many copies of DNA or RNA from one original template.
Pharyngeal Diseases
Pathological processes involving the PHARYNX.
Trichomonas vaginalis
A species of TRICHOMONAS that produces a refractory vaginal discharge in females, as well as bladder and urethral infections in males.
Pelvic Inflammatory Disease
A spectrum of inflammation involving the female upper genital tract and the supporting tissues. It is usually caused by an ascending infection of organisms from the endocervix. Infection may be confined to the uterus (ENDOMETRITIS), the FALLOPIAN TUBES; (SALPINGITIS); the ovaries (OOPHORITIS), the supporting ligaments (PARAMETRITIS), or may involve several of the above uterine appendages. Such inflammation can lead to functional impairment and infertility.
Serotyping
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
Vagina
The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)
Meningitis, Meningococcal
A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8)
Anti-Infective Agents
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Reagent Kits, Diagnostic
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
Drug Resistance, Bacterial
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Uterine Cervicitis
Inflammation of the UTERINE CERVIX.
Agglutination Tests
Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)
Tetracycline
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Specimen Handling
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
Antibodies, Bacterial
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Bacterial Adhesion
Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
Male Urogenital Diseases
Pathological processes of the male URINARY TRACT and the reproductive system (GENITALIA, MALE).
Neisseriaceae Infections
Infections with bacteria of the family NEISSERIACEAE.
Quinolones
A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.
Neisseria meningitidis, Serogroup W-135
Strains of Neisseria meningitidis found mostly in Africa.
Urine
Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.
Cephalosporins
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
Transferrin-Binding Protein B
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN A.
Trichomonas Infections
Infections in birds and mammals produced by various species of Trichomonas.
Cytidine Monophosphate N-Acetylneuraminic Acid
A nucleoside monophosphate sugar which donates N-acetylneuraminic acid to the terminal sugar of a ganglioside or glycoprotein.
Lipopolysaccharides
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Neisseria meningitidis, Serogroup C
Strains of Neisseria meningitidis responsible for most sporadic cases in teenagers and almost all outbreaks of disease in this age group. These strains are less common in infants.
Tetracycline Resistance
Nonsusceptibility of bacteria to the action of TETRACYCLINE which inhibits aminoacyl-tRNA binding to the 30S ribosomal subunit during protein synthesis.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Urethral Diseases
Pathological processes involving the URETHRA.
Transferrin-Binding Protein A
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN B.
Peptidoglycan
Sexually Transmitted Diseases
Diseases due to or propagated by sexual contact.
Neisseria meningitidis, Serogroup A
Strains of Neisseria meningitidis responsible for most outbreaks of meningococcal disease in Western Europe and the United States in the first half of the 20th century. They continue to be a major cause of disease in Asia and Africa, and especially localized epidemics in Sub-Sahara Africa.
Salpingitis
Inflammation of the uterine salpinx, the trumpet-shaped FALLOPIAN TUBES, usually caused by ascending infections of organisms from the lower reproductive tract. Salpingitis can lead to tubal scarring, hydrosalpinx, tubal occlusion, INFERTILITY, and ectopic pregnancy (PREGNANCY, ECTOPIC)
Trichomonas Vaginitis
Inflammation of the vagina, marked by a purulent discharge. This disease is caused by the protozoan TRICHOMONAS VAGINALIS.
Evaluation Studies as Topic
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Neisseria meningitidis, Serogroup Y
Strains of Neisseria meningitidis which, in the United States, causes disease in mostly adults and the elderly. Serogroup Y strains are associated with PNEUMONIA.
Moraxella
A genus of gram-negative, aerobic bacteria occurring as rods (subgenus Moraxella) or cocci (subgenus Branhamella). Its organisms are parasitic on the mucous membranes of humans and other warm-blooded animals.
Mycoplasma genitalium
A species of gram-negative bacteria originally isolated from urethral specimens of patients with non-gonoccocal URETHRITIS. In primates it exists in parasitic association with ciliated EPITHELIAL CELLS in the genital and respiratory tracts.
Norfloxacin
A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
Plasmids
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Fluoroquinolones
A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.
Female Urogenital Diseases
Pathological processes of the female URINARY TRACT and the reproductive system (GENITALIA, FEMALE).
Cefotaxime
Semisynthetic broad-spectrum cephalosporin.
Antigenic Variation
Change in the surface ANTIGEN of a microorganism. There are two different types. One is a phenomenon, especially associated with INFLUENZA VIRUSES, where they undergo spontaneous variation both as slow antigenic drift and sudden emergence of new strains (antigenic shift). The second type is when certain PARASITES, especially trypanosomes, PLASMODIUM, and BORRELIA, survive the immune response of the host by changing the surface coat (antigen switching). (From Herbert et al., The Dictionary of Immunology, 4th ed)
Cefuroxime
Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Penicillin G Procaine
Semisynthetic antibiotic prepared by combining penicillin G with PROCAINE.
Ophthalmia Neonatorum
Acute conjunctival inflammation in the newborn, usually caused by maternal gonococcal infection. The causative agent is NEISSERIA GONORRHOEAE. The baby's eyes are contaminated during passage through the birth canal.
Thiamphenicol
A methylsulfonyl analog of CHLORAMPHENICOL. It is an antibiotic and immunosuppressive agent.
Ceftizoxime
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Leukorrhea
A clear or white discharge from the VAGINA, consisting mainly of MUCUS.
Transformation, Genetic
Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.
Penicillin-Binding Proteins
Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.
Bacterial Typing Techniques
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
DNA Gyrase
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Pharynx
A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).
Ampicillin
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
DNA Topoisomerase IV
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
Gene Expression Regulation, Bacterial
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Haemophilus ducreyi
A species of HAEMOPHILUS that appears to be the pathogen or causative agent of the sexually transmitted disease, CHANCROID.

Effect of a staphylococcin on Neisseria gonorrhoeae. (1/2711)

Phage group 2 staphylococcal strain UT0002 contains a large 56S virulence plasmid with genes that code for both exfoliative toxin and a specific staphylococcin termed Bac R(1). Four penicillinase-producing strains and three penicillin-susceptible strains of Neisseria gonorrhoeae were killed by Bac R(1). After 30 min of growth of the penicillin-resistant TR1 strain in 62.5 arbitrary units of Bac R(1) per ml, loss of viability was approximately 90%, and, after 5 h, an approximately 99.99% loss of viability was observed. Lysis did not accompany cell death, and 84% of the Bac R(1) added to the growth medium was adsorbed to the gonococcal cells. The extracellular supernatant fluid from a substrain of staphylococcal strain UT0002 cured of the plasmid for Bac R(1) production had no lethal effect on the gonococcal strains. Bac R(1) was also shown to have bactericidal activity against an L-form of N. meningitidis, indicating that the outer envelope of a neisserial cell is not needed for bacteriocin activity. Ten different normal human sera were unable to neutralize Bac R(1) activity. The bacteriocin lacks adsorption specificity. It binds to but does not kill Escherichia coli cells, indicating that the cell envelope of gram-negative organisms can provide protection against the staphylococcin.  (+info)

Invasion of human mucosal epithelial cells by Neisseria gonorrhoeae upregulates expression of intercellular adhesion molecule 1 (ICAM-1). (2/2711)

Infection of the mucosa by Neisseria gonorrhoeae involves adherence to and invasion of epithelial cells. Little is known, however, about the expression by mucosal epithelial cells of molecules that mediate cellular interactions between epithelial cells and neutrophils at the site of gonococcal infection. The aim of this study was to determine the expression of intercellular adhesion molecule 1 (ICAM-1) by epithelial cells during the process of gonococcal invasion. The highly invasive strain FA1090 and the poorly invasive strain MS11 were incubated with human endometrial adenocarcinoma (HEC-1-B) or human cervical carcinoma (ME-180) epithelial cells, after which ICAM-1 expression was measured by flow cytometry. After 15 h of infection with FA1090, expression of ICAM-1 increased 4.7- and 2.1-fold for HEC-1-B and ME-180 cells, respectively, whereas 15 h of infection of HEC-1-B cells with MS11 increased ICAM-1 expression only 1.6-fold. ICAM-1 expression was restricted to the cell surface, since no soluble ICAM-1 was detected. The distribution of staining was heterogeneous and mimicked that seen after treatment of HEC-1-B cells with the ICAM-1 agonist tumor necrosis factor alpha (TNF-alpha) in the absence of bacteria. PCR and dot blot analyses of ICAM-1 mRNA showed no change in levels over time in response to infection. Although TNF-alpha was produced by HEC-1-B cells after infection, the extent of ICAM-1 upregulation was not affected by neutralizing anti-TNF-alpha antiserum. Dual-fluorescence flow cytometry showed that the cells with the highest levels of ICAM-1 expression were cells with associated gonococci. We conclude that epithelial cells upregulate the expression of ICAM-1 in response to infection with invasive gonococci. On the mucosa, upregulation of ICAM-1 by infected epithelial cells may function to maintain neutrophils at the site of infection, thereby reducing further invasion of the mucosa by gonococci.  (+info)

Longitudinal evaluation of serovar-specific immunity to Neisseria gonorrhoeae. (3/2711)

The serovars of Neisseria gonorrhoeae that are predominant in a community change over time, a phenomenon that may be due to the development of immunity to repeat infection with the same serovar. This study evaluated the epidemiologic evidence for serovar-specific immunity to N. gonorrhoeae. During a 17-month period in 1992-1994, all clients of a sexually transmitted disease clinic in rural North Carolina underwent genital culture for N. gonorrhoeae. Gonococcal isolates were serotyped according to standard methods. Odds ratios for repeat infection with the same serovar versus any different serovar were calculated on the basis of the distribution of serovars in the community at the time of reinfection. Of 2,838 patients, 608 (21.4%; 427 males and 181 females) were found to be infected with N. gonorrhoeae at the initial visit. Ninety patients (14.8% of the 608) had a total of 112 repeat gonococcal infections. Repeat infection with the same serovar occurred slightly more often than would be expected based on the serovars prevalent in the community at the time of reinfection, though the result was marginally nonsignificant (odds ratio = 1.5, 95% confidence interval 1.0-2.4; p = 0.05). Choosing partners within a sexual network may increase the likelihood of repeat exposure to the same serovar of N. gonorrhoeae. Gonococcal infection did not induce evident immunity to reinfection with the same serovar.  (+info)

Natural competence for DNA transformation by Legionella pneumophila and its association with expression of type IV pili. (4/2711)

We have recently described the expression of two pili of different lengths on the surface of Legionella pneumophila (B. J. Stone and Y. Abu Kwaik, Infect. Immun. 66:1768-1775, 1998). Production of long pili requires a functional pilEL locus, encoding a type IV pilin protein. Since type IV pili in Neisseria gonorrhoeae are associated with competence for DNA transformation, we examined the competence of L. pneumophila for DNA transformation under conditions that allowed the expression of type IV pili. We show that L. pneumophila is naturally competent for DNA transformation by isogenic chromosomal DNA and by plasmid DNA containing L. pneumophila DNA. Many different L. pneumophila loci are able to transform L. pneumophila after addition of plasmid DNA, including gspA, ppa, asd, and pilEL. The transformation frequency is reduced when competing DNA containing either L. pneumophila DNA or vector sequences is added to the bacteria, suggesting that uptake-specific sequences may not be involved in DNA uptake. Competence for DNA transformation correlates with expression of the type IV pili, and a pilEL mutant defective in expression of type IV pili is not competent for DNA transformation. Complementation of the mutant for competence is restored by the reintroduction of a cosmid that restores production of type IV pili. Minimal competence is restored to the mutant by introduction of pilEL alone. We conclude that competence for DNA transformation in L. pneumophila is associated with expression of the type IV pilus and results in recombination of L. pneumophila DNA into the chromosome. Since expression of type IV pili also facilitates attachment of L. pneumophila to mammalian cells and protozoa, we designated the type IV pili CAP (for competence- and adherence-associated pili).  (+info)

Identification of Neisseria gonorrhoeae from primary cultures by a slide agglutination test. (5/2711)

Hen antigonococcal lipopolysaccharide hen serum was used in a simple slide agglutination test for the identification of Neisseria gonorrhoeae from primary isolates.  (+info)

Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors. (6/2711)

We reported recently that the human opportunistic pathogen Pseudomonas aeruginosa strain PA14 kills Caenorhabditis elegans and that many P. aeruginosa virulence factors (genes) required for maximum virulence in mouse pathogenicity are also required for maximum killing of C. elegans. Here we report that among eight P. aeruginosa PA14 TnphoA mutants isolated that exhibited reduced killing of C. elegans, at least five also exhibited reduced virulence in mice. Three of the TnphoA mutants corresponded to the known virulence-related genes lasR, gacA, and lemA. Three of the mutants corresponded to known genes (aefA from Escherichia coli, pstP from Azotobacter vinelandii, and mtrR from Neisseria gonorrhoeae) that had not been shown previously to play a role in pathogenesis, and two of the mutants contained TnphoA inserted into novel sequences. These data indicate that the killing of C. elegans by P. aeruginosa can be exploited to identify novel P. aeruginosa virulence factors important for mammalian pathogenesis.  (+info)

Antimicrobial susceptibilities and plasmid contents of Neisseria gonorrhoeae isolates from commercial sex workers in Dhaka, Bangladesh: emergence of high-level resistance to ciprofloxacin. (7/2711)

Commercial sex workers (CSWs) serve as the most important reservoir of sexually transmitted diseases (STD), including gonorrhea. Periodic monitoring of the antimicrobial susceptibility profile of Neisseria gonorrhoeae in a high-risk population provides essential clues regarding the rapidly changing pattern of antimicrobial susceptibilities. A study concerning the prevalence of gonococcal infection among CSWs was conducted in Bangladesh. The isolates were examined with regards to their antimicrobial susceptibility to, and the MICs of, penicillin, tetracycline, ciprofloxacin, cefuroxime, ceftriaxone, and spectinomycin by disk diffusion and agar dilution methods. The total plasmid profile of the isolates was also analyzed. Of the 224 CSWs, 94 (42%) were culture positive for N. gonorrhoeae. There was a good correlation between the results of the disk diffusion and agar dilution methods. Some 66% of the isolates were resistant to penicillin, and 34% were moderately susceptible to penicillin. Among the resistant isolates, 23.4% were penicillinase-producing N. gonorrhoeae (PPNG). 60.6% of the isolates were resistant and 38.3% were moderately susceptible to tetracycline, 17.5% were tetracycline-resistant N. gonorrhoeae, 11.7% were resistant and 26.6% had reduced susceptibility to ciprofloxacin, 2.1% were resistant and 11.7% had reduced susceptibility to cefuroxime, and 1% were resistant to ceftriaxone. All PPNG isolates contained a 3.2-MDa African type of plasmid, and a 24.2-MDa conjugative plasmid was present in 34.1% of the isolates. Since quinolones such as ciprofloxacin are recommended as the first line of therapy for gonorrhea, the emergence of significant resistance to ciprofloxacin will limit the usefulness of this drug for treatment of gonorrhea in Bangladesh.  (+info)

Characterization of the recD gene of Neisseria gonorrhoeae MS11 and the effect of recD inactivation on pilin variation and DNA transformation. (8/2711)

Pilin antigenic variation in Neisseria gonorrhoeae may result following intrachromosomal recombination between homologous pil genes. Despite extensive study, recA is the only previously characterized gene known to be involved in this process. In this study, the gonococcal recD gene, encoding one subunit of the putative RecBCD holoenzyme, was characterized and its role in pilin variation assessed. The complete recD gene of N. gonorrhoeae MS11 was cloned and its nucleotide sequence determined. The gonococcal recD gene complemented a defined Escherichia coli recD mutant, based on plaque formation of bacteriophage lambda and the restoration of ATP-dependent nuclease activity. Inactivation of the gonococcal recD gene had no measurable effect on cell viability or survival following UV exposure, but did decrease the frequency of DNA transformation approximately threefold. The frequency at which non-parental pilin phenotypes were spawned was 12-fold greater in MS11 recD mutants compared with the parental MS11 rec+ strain. Similar results were obtained using recD mutants that were not competent for DNA transformation. Complementation of the MS11 recD mutant with a wild-type recD gene copy restored the frequency of pilin phenotypic variation to approximately wild-type levels. The nucleotide changes at pilE in the recD mutants were confined to the variable regions of the gene and were similar to changes previously attributed to gene conversion.  (+info)

Physical map of the chromosome of Neisseria gonorrhoeae FA1090 with locations of genetic markers, including opa and pil genes. ...Physical map of the chromosome of Neisseria gonorrhoeae FA1090 with locations of genetic markers, including opa and pil genes. ...
A physical map of the chromosome of Neisseria gonorrhoeae FA1090 has been constructed. Digestion of strain FA1090 DNA with NheI, SpeI, BglII, or PacI resulted in a limited number of fragments that were resolved by contour-clamped homogeneous electric field electrophoresis. The estimated genome size was 2,219 kb. To construct the map, probes corresponding to single-copy chromosomal sequences were used in Southern blots of digested DNA separated on pulsed-field gels, to determine how the fragments from different digests overlapped. Some of the probes represented identified gonococcal genes, whereas others were anonymous cloned fragments of strain FA1090 DNA. By using this approach, a macrorestriction map of the strain FA1090 chromosome was assembled, and the locations of various genetic markers on the map were determined. Once the map was completed, the repeated gene families encoding Opa and pilin proteins were mapped. The 11 opa loci of strain FA1090 were distributed over approximately 60% of ...
https://jb.asm.org/content/173/17/5476?ijkey=66f2e62eb3b28cb35d33f07dacfc95aa62d18af5&keytype2=tf_ipsecsha
Emergence of fluoroquinolone-resistant Neisseria gonorrhoeae in São Paulo, BrazilEmergence of fluoroquinolone-resistant Neisseria gonorrhoeae in São Paulo, Brazil
BELDA JUNIOR, Walter; VELHO, Paulo Eduardo Neves Ferreira; ARNONE, Marcelo and FAGUNDES, Luis Jorge. Emergence of fluoroquinolone-resistant Neisseria gonorrhoeae in São Paulo, Brazil. Braz. J. Microbiol. [online]. 2007, vol.38, n.2, pp.293-295. ISSN 1517-8382. http://dx.doi.org/10.1590/S1517-83822007000200020.. Continued monitoring of antimicrobial resistance patterns is essential in order for Sexually Transmitted Diseases (STD) treatment to be effective. Gonococci isolates from 65 patients in São Paulo were submitted to susceptibility testing, and a decreased susceptibility or resistance to ciprofloxacin was observed in 8.7% of these patients, indicating that Neisseria gonorrhoeae fluoroquinolone resistance is emerging in Brazil.. Keywords : anti-bacterial agents; ciprofloxacin; drug resistance; Neisseria gonorrhoeae. ...
http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1517-83822007000200020&lng=en&nrm=iso&tlng=en
Locations of genetic markers on the physical map of the chromosome of Neisseria gonorrhoeae FA1090. | Journal of BacteriologyLocations of genetic markers on the physical map of the chromosome of Neisseria gonorrhoeae FA1090. | Journal of Bacteriology
To increase the utility of the previously constructed physical map of the chromosome of Neisseria gonorrhoeae FA1090, 28 additional genetic markers were localized on the map. Cloned gonococcal genes were used to probe Southern blots of restriction enzyme-digested DNA separated on pulsed-field gels, thus identifying the fragment in each of several digests to which the probe hybridized and the map location of each gene. The addition of the new markers brings the total number of mapped loci for this strain to 68; the locations of all of those markers on the updated map are shown. ...
https://jb.asm.org/content/176/7/2055?ijkey=7f22425f816a0b05503d35359d925ce478768742&keytype2=tf_ipsecsha
Evaluation of predominant Neisseria gonorrhoeae strain types and its c by Summiya Nizamuddin, Kauser Jabeen et al.Evaluation of predominant Neisseria gonorrhoeae strain types and its c by Summiya Nizamuddin, Kauser Jabeen et al.
OBJECTIVE: To study the predominant Neisseria gonorrhoeae strain types in Pakistan and to evaluate their correlation with fluoroquinolone resistance. METHOD: A total of 314 strains were collected from 2007-2009. Of these 112 strains were randomly selected for serotyping via the coagglutination technique. Fluoroquinolone susceptibility was checked through the E-test method. Chi square was performed to assess the correlation between the strain type and fluoroquinolone resistance pattern. RESULTS: N. gonorrhoeae isolates were typed in two serogroups and 28 serovars. Serogroup WI comprised 40% (n = 45) whereas WII/WIII was 60% (n = 67). Most commonly isolated serovar belonged to serogroup WI namely Aorst (10%). The other predominant circulating serovars of the serogroup WI were Aost (9%) and Ast (8%) and Bsy (8%), Bopyt (5%) and Bprt (4.5%) in the serogroup WII/III. Fluoroquinolone resistance was 98%, with an MIC of 2 microg/mL in 47%, 4 microg/mL in 36% and | 32 microg/mL in 12% of the isolates. On
https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/22/
Genetic variation regulates the activation and specificity of Restriction-Modification systems in Neisseria gonorrhoeae
ABSTRACT Restriction-Modification systems (RMS) are one of the main mechanisms of defence against foreign DNA invasion and can have an important role in the regulation of gene expression. The obligate human pathogen Neisseria gonorrhoeae carries one of the highest loads of RMS in its genome; between 13 to 15 of the three main types. Previous work has described their organization in the reference genome FA1090 and has experimentally inferred the associated methylated motifs. Here, we studied the structure of RMS and target methylated motifs in 25 gonococcal strains sequenced with Single Molecule Real-Time (SMRT) technology, which provides data on DNA modification. The results showed a variable picture of active RMS in different strains, with phase variation switching the activity of Type III RMS, and both the activity and specificity of a Type I RMS. Interestingly, the Dam methylase was found in place of the NgoAXI endonuclease in two of the strains, despite being previously thought to be absent ...
https://www.repository.cam.ac.uk/handle/1810/300661
Antimicrobial susceptibility of Neisseria gonorrhoeae strains isolated in Guangzhou, China, 1996-2001. - ScienceOpenAntimicrobial susceptibility of Neisseria gonorrhoeae strains isolated in Guangzhou, China, 1996-2001. - ScienceOpen
To investigate the in vitro antimicrobial susceptibility and resistant trends of Neisseria gonorrhoeae strains isolated in Guangzhou, from 1996 to 2001. The agar dilution method was used to determine the minimum inhibitory concentrations (MICs) to four antimicrobials, penicillin G, ciprofloxacin, ceftriaxone, and spectinomycin. The resistance of all strains to four antibiotics was interpreted according to criteria used in the project of surveillance of gonococcal antibiotic susceptibility in the WHO Western Pacific Region. Penicillinase producing N gonorrhoeae (PPNG) was analysed by the paper acidometric method. 793 consecutive N gonorrhoeae isolates collected in Guangzhou were studied from 1996 to 2001. A total of 55 strains of PPNG were identified and the prevalence rapidly spread from 2% to 21.8%. Of the four antibiotics examined, ceftriaxone and spectinomycin appeared to be the most effective agents although two spectinomycin resistant strains were isolated in 1996. Their MIC(50), MIC(90), ...
https://www.scienceopen.com/document?vid=2b855de0-5735-442d-b557-75201a4b99e1
Differentiation of Neisseria gonorrhoeae strains by polymerase chain reaction and restriction fragment length polymorphism of...Differentiation of Neisseria gonorrhoeae strains by polymerase chain reaction and restriction fragment length polymorphism of...
OBJECTIVES--To employ polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis for the rapid differentiation of Neisseria gonorrhoeae protein IB (PIB) isolates and to compare its usefulness with the widely accepted auxotype/serovar classification scheme. METHODS--The outer membrane protein IB genes of 47 gonococcal isolates belonging to 10 different serovars were amplified by PCR. The approximately 1 kb DNA products were then digested separately with restriction enzymes CfoI and MspA1I, and electrophoresed on agarose gels. RESULTS--Cleavage of PIB genes by MspA1I and CfoI differentiated all the N gonorrhoeae strains into five and six PCR-RFLP profiles, respectively. PCR-RFLP was more discriminatory than auxotyping, which classifies the strains into only two auxotypes. Some strains belonging to common serovars could be further differentiated. A combination of PCR-RFLP analysis, auxotyping and serotyping further increased the discrimination of the strains into ...
http://sti.bmj.com/content/71/6/363
MODULATION OF APOPTOSIS IN HUMAN URETHRAL EPITHELIAL CELLS BY WILD-TYPE NEISSERIA GONORRHOEAE AND ITS ISOGENIC MinD MUTANT...
The obligate human pathogen, Neisseria gonorrhoeae, has evolved mechanisms to manipulate the apoptotic machinery in human epithelial cells in favor of host niche adaptation. In the present research, I investigated the apoptotic effect of N. gonorrhoeae on transduced human urethral epithelial cells (THUEC) and the underlying mechanism of apoptosis modulation. Flow cytometric analysis showed that gonococcal infection conferred an anti-apoptotic effect in early infection, but induced apoptosis during prolonged infection periods in THUEC. Intracellular gonococci were required to provide the anti-apoptotic effect. Furthermore, immunoblotting analysis of the mitogen-activated protein kinase (MAPK) pathways mapped the apoptosis resistance to a signaling cascade involving epidermal growth factor receptor (EGFR), extracellular signal-regulated kinases (ERK), and Bim/Bad, in which the inhibition of ERK activation by N. gonorrhoeae contributed to the anti-apoptotic effect on THUEC. A N. gonorrhoeae minD ...
https://ecommons.usask.ca/handle/10388/ETD-2012-11-764
Design of a multiplex PCR assay for the simultaneous detection and confirmation of Neisseria gonorrhoeae | Journal of Clinical...Design of a multiplex PCR assay for the simultaneous detection and confirmation of Neisseria gonorrhoeae | Journal of Clinical...
Objectives To improve the detection of Neisseria gonorrhoeae by designing a multiplex PCR assay using two N gonorrhoeae-specific genes as targets, thereby providing detection and confirmation of a positive result simultaneously.. Methods PCR primers were designed to detect two N gonorrhoeae genes, namely porA and pgi1. Primers for an internal control targeting the ompW gene of Vibrio cholerae were also designed and incorporated in the assay. The DNA of 45 clinical isolates including 33 N gonorrhoeae isolates, seven non-gonococcal Neisseria species, and five non-Neisseria species was tested using the multiplex PCR assay.. Results All 33 N gonorrhoeae isolates were successfully detected by the assay and none of the non-gonococcal isolates was detected. The assay showed a sensitivity and specificity of 100%, and a limit of detection of 1.25 ng of DNA.. Conclusion This multiplex PCR assay offers a sensitive and specific assay suitable for the detection of N gonorrhoeae, and offers real potential for ...
http://jcp.bmj.com/content/63/5/431
Welcome to CDC stacks | Screening tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae infections -- 2002 - 5475 |...Welcome to CDC stacks | Screening tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae infections -- 2002 - 5475 |...
Since publication of CDCs 1993 guidelines (CDC. Recommendations for the prevention and management of Chlamydia trachomatis infections, 1993. MMWR 1993;42[No. RR-12]:1--39), nucleic acid amplification tests (NAATs) have been introduced as critical new tools to diagnose and treat C. trachomatis and Neisseria gonorrhoeae infections. NAATs for C. trachomatis are substantially more sensitive than previous tests. When using a NAAT, any sacrifice in performance when urine is substituted for a traditional swab specimen is limited, thus reducing dependence on invasive procedures and expanding the venues where specimens can be obtained. NAATs can also detect both C. trachomatis and N. gonorrhoeae organisms in the same specimen. However, NAATs are usually more expensive than previous tests, making test performance from an economic perspective a key consideration. This report updates the 1993 guidelines for selecting laboratory tests for C. trachomatis with an emphasis on screening men and women in the ...
https://stacks.cdc.gov/view/cdc/5475
Neisseria gonorrhoeae Infections - Pipeline Review, H2 2016 | Global Market Research ReportsNeisseria gonorrhoeae Infections - Pipeline Review, H2 2016 | Global Market Research Reports
Global Markets Directs, Neisseria gonorrhoeae Infections - Pipeline Review, H2 2016, provides an overview of the Neisseria gonorrhoeae Infections pipeline landscape.
http://www.gosreports.com/neisseria-gonorrhoeae-infections-pipeline-review-h2-2016/
H5N1: Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level...
Via Eurosurveillance: Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018. The abstract: We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a...
https://crofsblogs.typepad.com/h5n1/2018/07/gonorrhoea-treatment-failure-caused-by-a-neisseria-gonorrhoeae-strain-with-combined-ceftriaxone-and-high-level-azithromycin-r.html
Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses.
Gonorrhea is one of the most prevalent sexually transmitted diseases in the world. A naturally occurring variation of the terminal carbohydrates on the lipooligosaccharide (LOS) molecule correlates with altered disease states. Here, we investigated t
http://www.biomedsearch.com/nih/Variation-Neisseria-gonorrhoeae-lipooligosaccharide-directs/19834553.html
Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infection in adolescents in Northern Italy: an observational...Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infection in adolescents in Northern Italy: an observational...
We carried out a study to evaluate the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae genital infections in school-based adolescents in Northern Italy. Systematic screening for C. trachomatis and N. gonorrhoeae genital infection was performed in 13th grade students in the province of Brescia, an industrialized area in Northern Italy. Student filled in a questionnaire on sexual behaviour and provided a urine sample for microbiological testing. A total of 2,718 students (mean age: 18.4 years; 59.1 % females) provided complete data (62.2 % of those eligible). Overall 2,059 students (75.8 %) were sexually active (i.e. had had at least one partner), and the mean age at sexual debut was 16.1 years (SD: 1.4). Only 27.5 % of the sexually active students reported regular condom use during the previous 6 months, with higher frequency in males than in females (33.8 % vs 24.2 %). No case of N. gonorrhoeae infection was detected, while C. trachomatis was found in 36 adolescents, with a prevalence of 1
https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-016-2839-x/tables/2
OPUS Würzburg | SearchOPUS Würzburg | Search
The obligate human pathogen Neisseria gonorrhoeae is responsible for the widespread sexually transmitted disease gonorrhoea, which in rare cases also leads to the development of disseminated gonococcal infection (DGI). DGI is mediated by PorBIA-expressing bacteria that invade host cells under low phosphate condition by interaction with the scavenger receptor-1 (SREC-I) expressed on the surface of endothelial cells. The interaction of PorBIA and SREC-I was analysed using different in vitro approaches, including surface plasmon resonance experiments that revealed a direct phosphate-independent high affinity interaction of SREC-I to PorBIA. However, the same binding affinity was also found for the other allele PorBIB, which indicates unspecific binding and suggests that the applied methods were unsuitable for this interaction analysis. Since N. gonorrhoeae was recently classified as a super-bug due to a rising number of antibiotic-resistant strains, this study aimed to discover inhibitors against ...
https://opus.bibliothek.uni-wuerzburg.de/solrsearch/index/search/searchtype/all/rows/100/facetNumber_subject/all/institutefq/Theodor-Boveri-Institut+f%C3%BCr+Biowissenschaften/start/0/subjectfq/Neisseria+gonorrhoeae
Azithromycin Susceptibility Among Neisseria gonorrhoeae Isolates and Seasonal Macrolide Use. - MIDASAzithromycin Susceptibility Among Neisseria gonorrhoeae Isolates and Seasonal Macrolide Use. - MIDAS
Rising azithromycin nonsusceptibility among Neisseria gonorrhoeae isolates threatens current treatment recommendations, but the cause of this rise is not well understood. We performed an ecological study of seasonal patterns in macrolide use and azithromycin resistance in N. gonorrhoeae, finding that population-wide macrolide use is associated with increased azithromycin nonsusceptibility. These results, indicative of bystander selection, have implications for antibiotic prescribing guidelines ...
https://midasnetwork.us/papers/azithromycin-susceptibility-among-neisseria-gonorrhoeae-isolates-and-seasonal-macrolide-use/
Ceftriaxone-Resistant Neisseria gonorrhoeae, Japan - Volume 17, Number 1-January 2011 - Emerging Infectious Disease journal -...
To the Editor: Spread of multidrug-resistant Neisseria gonorrhoeae is a major public health concern. Effective antimicrobial therapy is a key element in gonorrhea control. However, N. gonorrhoeae has developed resistance to multiple classes of antimicrobial drugs, including β-lactams, tetracyclines, and fluoroquinolones (1-3). Even an extended-spectrum oral cephalosporin-resistant, cefixime-resistant N. gonorrhoeae has emerged, and cefixime has now been withdrawn from use in Japan. Best practice treatment is limited to injectable extended-spectrum cephalosporins, such as ceftriaxone and spectinomycin. The emergence of ceftriaxone-resistant N. gonorrhoeae threatens effective disease control.. We identified a novel ceftriaxone-resistant N. gonorrhoeae isolated from a 31-year-old female commercial sex worker; MIC of ceftriaxone for this isolate was high (2 µg/mL). The woman visited a clinic in Kyoto for a routine examination for sexually transmitted infections in January 2009. Although she had no ...
https://wwwnc.cdc.gov/eid/article/17/1/10-0397_article
Welcome to CDC stacks | Identification of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain FC428...Welcome to CDC stacks | Identification of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain FC428...
In 2016, we identified a ceftriaxone-resistant Neisseria gonorrhoeae isolate in China. The strain genotype was identical to the resistant clone FC428 that originated in Japan. Enhanced international collaborative surveillance programs are crucial to track the transmission of the ceftriaxone-resistant clones ...
https://stacks.cdc.gov/view/cdc/79638
Studies on local isolates of neisseria gonorrhoeae:role in different clinical populations antimicrobial profile and mechanisms...Studies on local isolates of neisseria gonorrhoeae:role in different clinical populations antimicrobial profile and mechanisms...
Studies were performed on local isolates of Neisseria gonorrhoeae to assess their aetiological role in different clinical populations, to determine the evolution of antimicrobial resistance and characterisation of quinolone resistance. In the study performed on women presenting for termination of pregnancy (TOP) the prevalence of common sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis) was much higher than reported from other studies in TOP populations. The commonest organism isolated was C. trachomatis. There were no significant differences in infection rates in women with or without signs and symptoms of vaginal discharge. Therefore all women presenting for TOP need to be screened and treated for sexually transmitted pathogens. In the study to determine the co-infection rates in men presenting with urethritis (discharge and/or burning on micturition (BOM)), the overall infection rate was 65% with co-infections (more than one pathogen ...
http://ulspace.ul.ac.za/handle/10386/277
Neisseria gonorrhoeae MntC protein Summary Report | CureHunterNeisseria gonorrhoeae MntC protein Summary Report | CureHunter
Neisseria gonorrhoeae MntC protein: a periplasmic-binding protein that be a component of an ABC transporter that imports manganese ion to combat oxidative stress; isolated from Neisseria gonorrhoeae; GenBank AE004969
http://www.curehunter.com/public/keywordSummaryC432956-Neisseria-gonorrhoeae-MntC-protein.do
DiVA - Search resultDiVA - Search result
Background: This study aimed to investigate the prevalence of penicillinase-producing Neisseria gonorrhoeae (PPNG) and their bla(TEM-135) gene variant in 2007 and 2012 in Nanjing, China. In addition, molecular epidemiological typing of all isolates was performed to elucidate the genetic relationships of the PPNG strains. Methods: A total of 199 and 77 N. gonorrhoeae isolates were collected at the National Center for STD Control in 2007 and 2012, respectively. Nitrocefin tests were performed to identify PPNG. Mismatch amplification mutation assay was used to identify bla(TEM-135). All isolates were genotyped using N. gonorrhoeae multiantigen sequence typing (NG-MAST), and additionally, porB-based phylogenetic analysis was performed for the PPNG isolates. Results: The total prevalence of PPNG isolates was 41% (114/276) and 58% (66/114) of these PPNG isolates possessed bla(TEM-135). In 2007, 45% (90/199) produced beta-lactamase, and of those PPNG, 58% (52/90) possessed bla(TEM-135). In 2012, 31% ...
http://oru.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22journalId%22%3A%228832%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=
Attachment of Neisseria gonorrhoeae to human sperm. Microscopical study of trypsin and iron | Meta
Pilated Neisseria gonorrhoeae of colony type 1 (T1) and non-pilated bacteria of colony type 4 (T4) were observed by transmission (TEM) and scanning electron microscopy (SEM). No pili were observed on T4 gonogocci, but two types of pili--straight, type a, and bent, type b--were seen on T1 by TEM. When incubated with human sperum and examined by either TEM or SEM, T1 gonococci were seen to attach by individual pili, by several pili wound together as a rope, or by direct contact. Gonococci from T4 colonies attached only by direct contact. Treatment with typsin (1 mg/ml) damaged or removed pili from gonococci. After incubation with trypsin, attachment of pilated gonococci to sperm was decreased significantly, but such treatment did not affect attachment of non-pilated gonococci. Incubation of gonococci from either colony type in 0.1 mmol/l ferric nitrate, followed by incubation with sperm, significantly increased attachment of only T4 bacteria. No pili were seen on T4 gonococci treated with ferric ...
https://www.meta.org/papers/attachment-of-neisseria-gonorrhoeae-to-human/39583
Analysis of Mutations Within Multiple Genes Associated With Resistance in a Clinical Isolate of Neisseria Gonorrhoeae With...Analysis of Mutations Within Multiple Genes Associated With Resistance in a Clinical Isolate of Neisseria Gonorrhoeae With...
A Neisseria gonorrhoeae strain with a reduced susceptibility to ceftriaxone (minimum inhibitory concentration (MIC) = 0.5 microg/mL) was isolated among 398 clinical isolates obtained from 2000-2001 in Fukuoka City, Japan. The N. gonorrhoeae strain was negative for penicillinase production but it sho …
https://pubmed.ncbi.nlm.nih.gov/16318912/?dopt=Abstract
Chlamydia trachomatis & Neisseria gonorrhoeae DNA ProbeChlamydia trachomatis & Neisseria gonorrhoeae DNA Probe
Chlamydia trachomatis & Neisseria gonorrhoeae DNA Probe,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories client,medicine,medical supply,medical supplies,medical product
http://www.bio-medicine.org/medicine-products/Chlamydia-trachomatis--26-Neisseria-gonorrhoeae-DNA-Probe-22028-1/
Neisseria gonorrhoeae FA19 supercont1.10 genomic scaffold, whole genom - Nucleotide - NCBINeisseria gonorrhoeae FA19 supercont1.10 genomic scaffold, whole genom - Nucleotide - NCBI
Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More... ...
https://www.ncbi.nlm.nih.gov/nuccore/222154489?report=fasta
Identification and purification of a hemoglobin-binding outer membrane protein from Neisseria gonorrhoeae. | Infection and...Identification and purification of a hemoglobin-binding outer membrane protein from Neisseria gonorrhoeae. | Infection and...
The majority of in vitro-grown Neisseria gonorrhoeae strains were unable to use hemoglobin as the sole source of iron for growth (Hgb-), but a minor population was able to do so (Hgb+). The ability of Hgb+ gonococci to utilize hemoglobin as the iron source was associated with the expression of an iron-repressible 89-kDa hemoglobin-binding protein in the outer membrane. The N-terminal amino acid sequence of this protein revealed amino acids, from positions 2 to 16, identical to those of HpuB, an 85 kDa iron-regulated hemoglobin-haptoglobin utilization outer membrane protein of Neisseria meningitidis. Isogenic mutants constructed by allelic replacement with a meningococcal hpu::mini-Tn3erm construct no longer expressed the 89-kDa protein. Mutants could not utilize hemoglobin to support growth but still grew on heme. Thus, the gonococcal HpuB homolog is a functional hemoglobin receptor and is essential for growth with hemoglobin. ...
https://iai.asm.org/content/64/12/5008?ijkey=8e709e0e533d46291c19cc1856a63beda95a750f&keytype2=tf_ipsecsha
Plasmids in Neisseria gonorrhoeae are associated with distinct lineages and economic status of their country of origin - Oxford...
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https://www.neuroscience.ox.ac.uk/publications/1084473
RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates - Nuffield Department of...
Abstract Increasing Neisseria gonorrhoeae resistance to ceftriaxone, the last antibiotic recommended for empiric gonorrhea treatment, poses an urgent public health threat. However, the genetic basis of reduced susceptibility to ceftriaxone is not completely understood: while most ceftriaxone resistance in clinical isolates is caused by target site mutations in penA , others lack these mutations. Here, we show that penA -independent ceftriaxone resistance has evolved multiple times through distinct mutations in rpoB and rpoD . We identify five mutations in these genes that each increase resistance to ceftriaxone, including one mutation that arose independently in two lineages, and show that clinical isolates from multiple lineages are a single nucleotide change from ceftriaxone resistance. These RNA polymerase mutations result in large-scale transcriptional changes without altering susceptibility to other antibiotics, reducing growth rate, or deranging cell morphology. These results underscore the
https://www.ndph.ox.ac.uk/publications/1049071
Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae. - Peter Medawar Building for...
BACKGROUND: Antimicrobial resistance in Neisseria gonorrhoeae is a global health concern. Strains from two internationally circulating sequence types, ST-7363 and ST-1901, have acquired resistance to third-generation cephalosporins, mainly due to mosaic penA alleles. These two STs were first detected in Japan; however, the timeline, mechanism, and process of emergence and spread of these mosaic penA alleles to other countries remain unknown. METHODS: We studied the evolution of penA alleles by obtaining the complete genomes from three Japanese ST-1901 clinical isolates harboring mosaic penA allele 34 (penA-34) dating from 2005 and generating a phylogenetic representation of 1075 strains sampled from 35 countries. We also sequenced the genomes of 103 Japanese ST-7363 N. gonorrhoeae isolates from 1996 to 2005 and reconstructed a phylogeny including 88 previously sequenced genomes. RESULTS: Based on an estimate of the time-of-emergence of ST-1901 (harboring mosaic penA-34) and ST-7363 (harboring mosaic
https://www.medawar.ox.ac.uk/publications/1170085
RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates. - Oxford Big Data Institute
Increasing Neisseria gonorrhoeae resistance to ceftriaxone, the last antibiotic recommended for empiric gonorrhea treatment, poses an urgent public health threat. However, the genetic basis of reduced susceptibility to ceftriaxone is not completely understood: while most ceftriaxone resistance in clinical isolates is caused by target site mutations in penA, some isolates lack these mutations. We show that penA-independent ceftriaxone resistance has evolved multiple times through distinct mutations in rpoB and rpoD. We identify five mutations in these genes that each increase resistance to ceftriaxone, including one mutation that arose independently in two lineages, and show that clinical isolates from multiple lineages are a single nucleotide change from ceftriaxone resistance. These RNA polymerase mutations cause large-scale transcriptional changes without altering susceptibility to other antibiotics, reducing growth rate, or deranging cell morphology. These results underscore the unexpected diversity
https://www.bdi.ox.ac.uk/publications/1085370
Lactate Acquisition Promotes Successful Colonization of the Murine Genital Tract by Neisseria gonorrhoeae | Infection and...Lactate Acquisition Promotes Successful Colonization of the Murine Genital Tract by Neisseria gonorrhoeae | Infection and...
At all stages of the disease process, bacteria must acquire nutrients from the surrounding microenvironment to sustain growth and replication. Recent findings from genetic screening methods to identify factors required for bacterial pathogenesis in vivo have served to emphasize the essential role of microbial physiology during pathogenesis (25, 35).. N. gonorrhoeae has stringent nutrient requirements for growth. Only a limited repertoire of carbon energy sources, including glucose and lactate, are effectively utilized by this bacterium (2). Both are available in the genital tract, the normal habitat of N. gonorrhoeae. While biochemical evidence has demonstrated the effect of additional lactate on gonococcal metabolism and resistance against complement, this is the first description of a strain of N. gonorrhoeae that is specifically unable to utilize this carbon source. This was achieved by taking advantage of the recent identification of the gene encoding the lactate permease in the related ...
https://iai.asm.org/content/75/3/1318.full
Is Neisseria gonorrhoeae Initiating a Future Era of Untreatable Gonorrhea?: Detailed Characterization of the First Strain with...Is Neisseria gonorrhoeae Initiating a Future Era of Untreatable Gonorrhea?: Detailed Characterization of the First Strain with...
The present study describes the detailed phenotypic and genetic confirmation and characterization, including elucidation of the resistance mechanisms, of the first identified N. gonorrhoeae strain (H041) displaying high-level resistance to ceftriaxone worldwide. H041 was isolated from a female commercial sex worker in Japan (23), and the ceftriaxone MIC of H041 was 4- to 8-fold higher than any previously observed. Ceftriaxone is also the last remaining option for empirical first-line treatment of gonorrhea. Accordingly, N. gonorrhoeae has now shown its ability to develop resistance to ceftriaxone also and, although the biological fitness of ceftriaxone resistance in N. gonorrhoeae remains unknown, the gonococcus may become a true superbug that initiates a future era of untreatable gonorrhea.. Although a posttreatment isolate was unavailable (only one specimen positive with SDA [ProbeTec ET; Becton-Dickinson], sampled 2 weeks after treatment) to definitively verify treatment failure using 1 g ...
https://aac.asm.org/content/55/7/3538
Thioredoxin Reductase is Essential for Protection of Neisseria gonorrhoeae against Killing by Nitric Oxide and for Bacterial...Thioredoxin Reductase is Essential for Protection of Neisseria gonorrhoeae against Killing by Nitric Oxide and for Bacterial...
In Neisseria gonorrhoeae, the MerR family transcription factor NmlR activates 3 operons in response to disulfide stress. In the present study, we show that trxB, a monocistronic operon under the control of NmlR, encodes a functional thioredoxin reductase. It is shown that neisserial TrxB has biochemical properties similar to those of its homologue from Escherichia coli. Analysis of a trxB mutant of N. gonorrhoeae showed that it was more sensitive to disulfide stress and to stress induced by organic hydroperoxides, superoxide, and nitric oxide than wild-type gonococcus. TrxB was found to be essential for the microaerobic induction of aniA and norB, the genes encoding nitrite reductase and nitric oxide reductase, respectively. The importance of TrxB during natural infection was demonstrated by the fact that the survival of gonococci within human cervical epithelial cells, as well as biofilm formation on these cells, was greatly reduced for a trxB mutant compared with a wild-type strain ...
https://research-repository.griffith.edu.au/handle/10072/33884
Microarray genomotyping of key experimental strains of Neisseria gonorrhoeae reveals gene complement diversity and five new...Microarray genomotyping of key experimental strains of Neisseria gonorrhoeae reveals gene complement diversity and five new...
The Neisseria gonorrhoeae population structure is not clonal [1-5], its panmictic structure being the result of horizontal genetic exchange [6]. The pathogenic Neisseria spp. are naturally transformable [7] and chromosomal changes are largely mediated by homologous recombination. Natural competence for transformation and homologous recombination allow the generation of mosaic genes, such as the divergent opa genes [8, 9], antigenic variation through recombination with silent cassettes, such as in the pilE/pilS system [10, 11], and the horizontal exchange of whole genes or groups of genes in Minimal Mobile Elements (MMEs) [12]. A Minimal Mobile Element (MME) is defined as a region between two conserved genes within which different genes are found in different strains. These elements are described as minimal reflecting the fact that they do not have features suggesting mobilization by associated transposases, nor do they currently appear to have features by which remotely encoded systems would ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-5-23
ASMscience | Neisseria gonorrhoeae: A
Uncomplicated gonorrhea is most commonly an acute urogenital infection involving the urethra in men and the endocervix in women of reproductive age. Upon entering the urogenital tract, Neisseria gonorrhoeae adheres to columnar epithelial cells, a step that presumably enables the gonococcus to withstand the flushing force of urine and the constant shedding of cervical mucus. Transcriptional regulation of genes in response to environmental stimuli in the mucus layer may coordinate adaptation of this pathogen to nutritionally different microenvironments and to physiological stress induced by nonspecific host defenses. The major pilin subunit, PilE, is encoded by one or two expression loci (pilE) on the chromosome. This chapter focuses on the survival mechanisms utilized by the gonococcus specifically in the context of the urogenital mucosa. The isolation of a gonococcal fur mutant by Thomas and Sparling facilitated the identification of numerous fur-dependent iron-induced (Fip) and iron-repressed (Frp)
http://www.asmscience.org/content/book/10.1128/9781555818104.chap11
MOUSE ANTI NEISSERIA GONORRHOEAE MOMP 30kDa Antibody | scrazzl.com - Simply Connecting Science
Major outer membrane proteins (MOMP) from a mixture of detergent-treated Neisseria gonorrhoeae strains: SB587, SB2262, SB2265 & SB2275 ...
http://scrazzl.com/242031/mouse-anti-neisseria-gonorrhoeae-momp-30kda-antibody
Antibiotics | Free Full-Text | Future Prospects for Neisseria gonorrhoeae TreatmentAntibiotics | Free Full-Text | Future Prospects for Neisseria gonorrhoeae Treatment
Gonorrhea is a sexually transmitted disease with a high morbidity burden. Incidence of this disease is rising due to the increasing number of antibiotic-resistant strains. Neisseria gonorrhoeae has shown an extraordinary ability to develop resistance to all antimicrobials introduced for its treatment. In fact, it was recently classified as a “Priority 2” microorganism in the World Health Organization (WHO) Global Priority List of Antibiotic-Resistant Bacteria to Guide Research, Discovery and Development of New Antibiotics. Seeing as there is no gonococcal vaccine, control of the disease relies entirely on prevention, diagnosis, and, especially, antibiotic treatment. Different health organizations worldwide have established treatment guidelines against gonorrhea, mostly consisting of dual therapy with a single oral or intramuscular dose. However, gonococci continue to develop resistances to all antibiotics introduced for treatment. In fact, the first strain of super-resistant N.gonorrhoeae
https://www.mdpi.com/2079-6382/7/2/49
Department of Health | Surveillance of antibiotic resistance in <em>Neisseria gonorrhoeae</em> in the WHO Western Pacific and...Department of Health | Surveillance of antibiotic resistance in <em>Neisseria gonorrhoeae</em> in the WHO Western Pacific and...
The World Health Organization (WHO) Gonococcal Antimicrobial Surveillance Programme (GASP) conducts surveillance of antimicrobial resistance in Neisseria gonorrhoeae in the WHO Western Pacific Region (WPR) and the South East Asian Region (SEAR) to optimise antibiotic treatment and control of gonococcal disease. This report details the results of this surveillance during 2010.
https://www.cancerscreening.gov.au/internet/main/publishing.nsf/Content/cda-cdi3601d.htm
Future Prospects for Neisseria gonorrhoeae Treatment[v1] | PreprintsFuture Prospects for Neisseria gonorrhoeae Treatment[v1] | Preprints
Gonorrhea is a sexually transmitted disease with a high morbidity burden. Incidence of this disease is rising due to the increasing number of antibiotic-resistant strains. Neisseria gonorrhoeae has shown an extraordinary ability to develop resistance to all antimicrobials introduced for its treatment. In fact, it was recently classified as a “Priority 2” microorganism in the WHO Global Priority List of Antibiotic-Resistant Bacteria to Guide Research, Discovery and Development of New Antibiotics. Seeing as there is no gonococcal vaccine, control of the disease relies entirely on prevention, diagnosis and, especially, antibiotic treatment. Different health organizations worldwide have established treatment guidelines against gonorrhea, mostly consisting in dual therapy with a single oral or intramuscular dose. However, gonococci continue to develop resistances to all antibiotics introduced for treatment. In fact, the first strain of super-resistant N. gonorrhoeae was recently detected in the
https://www.preprints.org/manuscript/201805.0315/v1
Heptose I glycan substitutions on Neisseria gonorrhoeae lipooligosacch by Sanjay Ram, Jutamas Ngampasutadol et al.Heptose I glycan substitutions on Neisseria gonorrhoeae lipooligosacch by Sanjay Ram, Jutamas Ngampasutadol et al.
Lipooligosaccharide (LOS) heptose (Hep) glycan substitutions influence gonococcal serum resistance. Several gonococcal strains bind the classical complement pathway inhibitor, C4b-binding protein (C4BP), via their porin (Por) molecule to escape complement-dependent killing by normal human serum (NHS). We show that the proximal glucose (Glc) on HepI is required for C4BP binding to Por1B-bearing gonococcal strains MS11 and 1291 but not to FA19 (Por1A). The presence of only the proximal Glc on HepI (lgtE mutant) permitted maximal C4BP binding to MS11 but not to 1291. Replacing 1291 lgtE Por with MS11 Por increased C4BP binding to levels that paralleled MS11 lgtE, suggesting that replacement of the Por1B molecule dictated the effects of HepI glycans on C4BP binding. The remainder of the strain background did not affect C4BP binding; replacing the Por of strain F62 with MS11 Por (F62 PorMS11) and truncating HepI mirrored the findings in the MS11 background. C4BP binding correlated with resistance to killing
https://escholarship.umassmed.edu/oapubs/1263/
Increasing Trend of Resistance to Penicillin, Tetracycline, and Fluoro by Kauser Jabeen, Summiya Nizamuddin et al.Increasing Trend of Resistance to Penicillin, Tetracycline, and Fluoro by Kauser Jabeen, Summiya Nizamuddin et al.
Emergence and spread of drug resistant Neisseria gonorrhoeae is global concern. We evaluated trends of antimicrobial resistance in Neisseria gonorrhoeae over years 1992-2009 in Pakistan. Resistance rates were compared between years (2007-2009) and (1992-2006). Antimicrobial susceptibility testing was performed and interpreted according to Clinical Laboratory Standards Institute (CLSI) criteria using the disk diffusion methodology against penicillin, ceftriaxone, tetracycline and ofloxacin. Additional antibiotics tested in 100 strains isolated during 2007-2009, included cefotaxime, cefoxitin, cefuroxime, cefipime, ceftazidime, ceftizoxime, cefixime, cefpodoxime, spectinomycin and azithromycin. Neisseria gonorrhoeae ATCC 49226 was used as control. Chi-square for trend analysis was conducted to assess resistance trend over the study period. During study period significant increase in combined resistance to penicillin, tetracycline and ofloxacin was observed (P value
https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/130/
Primary Diagnostics Laboratory: CHLAMYDIA/NEISSERIA GONORRHOEAE RNA, TMA
This test was performed using the APTIMA® COMBO2 Assay (GEN-PROBE).. Clinical Significance. C. trachomatis infections are the leading cause of sexually transmitted diseases in the United States. C. trachomatis is known to cause cervicitis, pelvic inflammatory disease (PID), epididymitis and proctitis. It is also the most frequent cause of non-gonococcal urethritis in men. Among women, the consequences of Chlamydial infections are severe if left untreated. Approximately half of Chlamydial infections are asymptomatic.Neisseria gonorrhoeae (gonococci) is the causative agent of gonorrhea. In men, this disease generally results in anterior urethritis accompanied by purulent exudate. In women, the disease is most often found in the cervix, but the vagina and uterus may also be infected.. Alternative Name(s) CT/NG APTIMA®, CT/GC APTIMA®, Hologic, CT/GC TMA, CT/NG TMA. ...
http://primarydiagnosticslaboratory.com/virtual-test-guide/chlamydianeisseria-gonorrhoeae-rna-tma-2/
Neisseria gonorrhoeae抗体(FITC)|Abcam中国|Anti-Neisseria gonorrhoeae抗体(FITC)Neisseria gonorrhoeae抗体(FITC)|Abcam中国|Anti-Neisseria gonorrhoeae抗体(FITC)
FITC偶联Neisseria gonorrhoeae抗体(ab20815)经ELISA, ICC/IF实验严格验证，实验条件参看说明书。Abcam对所有产品均提供质保服务和专属技术支持，中国75%以上现货。
http://www.abcam.cn/neisseria-gonorrhoeae-antibody-fitc-ab20815.html
Effects of recA Mutations on Pilus Antigenic Variation and Phase Transitions in Neisseria gonorrhoeae | GeneticsEffects of recA Mutations on Pilus Antigenic Variation and Phase Transitions in Neisseria gonorrhoeae | Genetics
Intragenic recombination between the single complete pilin gene (expression locus) and multiple, distinct, partial pilin gene copies (silent, storage loci) is thought to account for the generation of pilus antigenic diversity and piliation phase (on-off) changes exhibited by Neisseria gonorrhoeae. The mechanisms operating in the genomic rearrangements associated with these forms of pilus variation were investigated through the study of isogenic strains of gonococci bearing either wild-type or altered recA alleles. Examination of the rates of pilus phase variation and the genetic basis for changes in piliation status displayed by these strains show that recA mediated homologous recombination is required for these high frequency events and confirm that the nonpiliated state results from mutations in the expressed pilin gene. In a strain that is deficient in recA mediated homologous recombination, pilus phase variation occurs at a 100-1000-fold reduced rate and results predominantly from one class ...
https://www.genetics.org/content/117/3/391?ijkey=4d86a204aed9fe4d9590a927cbf66888d689a750&keytype2=tf_ipsecsha
Differing Neisseria gonorrhoeae bacterial loads in the pharynx and rectum in men who have sex with men: Implications for...
TY - JOUR. T1 - Differing Neisseria gonorrhoeae bacterial loads in the pharynx and rectum in men who have sex with men. T2 - Implications for gonococcal detection, transmission, and control. AU - Bissessor, M. AU - Tabrizi, S N. AU - Fairley, C. K.. AU - Danielewski, Jennifer A. AU - Whitton, B.. AU - Bird, S.. AU - Garland, S.. AU - Chen, M. Y.. PY - 2011/12. Y1 - 2011/12. N2 - The bacterial loads for gonococcal infections of the pharynx and rectum were determined among men with male sexual partners. The median bacterial load for rectal infections (18,960 copies/swab) was significantly higher than the load for pharyngeal infections (2,100 copies/swab; P = 0.001). Bacterial loads among men with symptomatic proctitis were strikingly high (median, 278,000 copies/swab).. AB - The bacterial loads for gonococcal infections of the pharynx and rectum were determined among men with male sexual partners. The median bacterial load for rectal infections (18,960 copies/swab) was significantly higher than ...
https://research.monash.edu/en/publications/differing-neisseria-gonorrhoeae-bacterial-loads-in-the-pharynx-an
Characterization of the recD gene of Neisseria gonorrhoeae MS11 and the effect of recD inactivation on pilin variation and DNA...Characterization of the recD gene of Neisseria gonorrhoeae MS11 and the effect of recD inactivation on pilin variation and DNA...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/10075421?dopt=Abstract
Penicillinase-producing Neisseria gonorrhoeae isolates from different localities in south east Asia. Susceptibility to 15...Penicillinase-producing Neisseria gonorrhoeae isolates from different localities in south east Asia. Susceptibility to 15...
Sixty four penicillinase-producing Neisseria gonorrhoeae (PPNG) and 24 non-penicillinase-producing (non-PPNG) strains isolated from six different south east Asian localities were tested by the agar dilution method against 15 antibiotics. All isolates were susceptible to spectinomycin and sulphamethoxazole-trimethoprim (19:1 ratio). A large proportion of both PPNG and non-PPNG strains showed, however, a decreased susceptibility to tetracycline, kanamycin, and erythromycin: 49% with minimum inhibitory concentrations (MICs) of tetracycline greater than or equal to 2 micrograms/ml, 34% with MICs of kanamycin greater than or equal to 32 micrograms/ml, and 80% with MICs of erythromycin greater than or equal to 2 micrograms/ml. These MIC cut-off values were chosen since they are close to the highest concentrations of these antibiotics attainable in serum after drug administration. Resistance to these antibiotics was not related to penicillinase production and does not appear to be confined to gonococci ...
http://sti.bmj.com/content/59/4/232
Antimicrobial susceptibility and genetic characteristics of Neisseria gonorrhoeae isolates from India, Pakistan and Bhutan in...Antimicrobial susceptibility and genetic characteristics of Neisseria gonorrhoeae isolates from India, Pakistan and Bhutan in...
Background: Knowledge on antimicrobial drug resistance and genetic characteristics of Neisseria gonorrhoeae isolates circulating in India, Pakistan, and Bhutan is sorely lacking. In this paper, we describe the prevalence of antimicrobial resistance and molecular characteristics of N. gonorrhoeae isolates from India, Pakistan, and Bhutan in 2007-2011. Methods: Antimicrobial susceptibility and beta-lactamase production were tested for 65 N. gonorrhoeae isolates from India (n=40), Pakistan (n=18) and Bhutan (n=7) using Etest methodology (eight antimicrobials) and nitrocefin solution, respectively. Resistance determinants, i.e. penA, mtrR, porB1b, gyrA, and parC, were sequenced. N. gonorrhoeae multiantigen sequence typing (NG-MAST) was performed for molecular epidemiology. Results: The highest resistance level was observed for ciprofloxacin (94%), followed by penicillin G (68%), erythromycin (62%), tetracycline (55%), and azithromycin (7.7%). All the isolates were susceptible to ceftriaxone, ...
http://oru.diva-portal.org/smash/record.jsf?pid=diva2:1083947
Lactobacillus crispatus inhibits growth of Gardnerella vaginalis and Neisseria gonorrhoeae on a porcine vaginal mucosa model |...Lactobacillus crispatus inhibits growth of Gardnerella vaginalis and Neisseria gonorrhoeae on a porcine vaginal mucosa model |...
The vaginal microbiota can impact the susceptibility of women to bacterial vaginosis (BV) and sexually transmitted infections (STIs). BV is characterized by depletion of Lactobacillus spp., an overgrowth of anaerobes (often dominated by Gardnerella vaginalis) and a pH | 4.5. BV is associated with an increased risk of acquiring STIs such as chlamydia and gonorrhea. While these associations have been identified, the molecular mechanism(s) driving the risk of infections are unknown. An ex vivo porcine vaginal mucosal model (PVM) was developed to explore the mechanistic role of Lactobacillus spp. in affecting colonization by G. vaginalis and Neisseria gonorrhoeae. The data presented here demonstrate that all organisms tested can colonize and grow on PVM to clinically relevant densities. Additionally, G. vaginalis and N. gonorrhoeae form biofilms on PVM. It was observed that lactic acid, acetic acid, and hydrochloric acid inhibit the growth of G. vaginalis on PVM in a pH-dependent manner. N. gonorrhoeae
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-015-0608-0/figures/4
Neisseria meningitidis Archives | Microbe NotesNeisseria meningitidis Archives | Microbe Notes
Differences between Neisseria meningitidis and Neisseria gonorrhoeae Neisseria meningitidis and Neisseria gonorrhoeae, are obligate human pathogens that cause distinctly different disease syndromes. They are both Gram negative diplococci, non-sporing, oxidase positive and difficult to differentiate on morphological and cultural characteristics. However, they can be differentiated on the following grounds: S.N. Character Neisseria gonorrhoeae Neisseria meningitidis 1. Commonly Called Gonococcus Meningococcus 2. …. Read more32 Differences between Neisseria meningitidis and Neisseria gonorrhoeae ...
https://microbenotes.com/tag/neisseria-meningitidis/
Opacity-associated protein A contributes to the binding of Haemophilus influenzae to chang epithelial cells<...
TY - JOUR. T1 - Opacity-associated protein A contributes to the binding of Haemophilus influenzae to chang epithelial cells. AU - Prasadarao, Nemani V.. AU - Lysenko, Elena. AU - Wass, Carol A.. AU - Kim, Kwang Sik. AU - Weiser, Jeffrey N.. PY - 1999/8. Y1 - 1999/8. N2 - Opacity-associated protein A (OapA), which is responsible for the transparent-colony phenotype of Haemophilus influenzae, has been implicated in the colonization of the nasopharynx in an infant rat model of carriage. In this report, we show that OapA mediates attachment to Chang epithelial cells examined by using genetically defined type b and nontypeable H. influenzae strains with or without OapA. We also showed that OapA was conserved among H. influenzae strains by comparing deduced amino acid sequences. Both recombinant OapA and polyclonal anti-OapA antiserum blocked the binding of H. influenzae to Chang epithelial cells, suggesting that the interaction of H. influenzae is specific to OapA. Moreover, the binding of ...
https://jhu.pure.elsevier.com/en/publications/opacity-associated-protein-a-contributes-to-the-binding-of-haemop-3
Evaluation of the RIM-N, Gonochek II, and Phadebact systems for the identification of pathogenic Neisseria spp. and Branhamella...
Methods for identifying Neisseria spp. include conventional and modified carbohydrate degradation procedures, chromogenic enzyme substrate tests, and immunologic coagglutination tests for Neisseria gonorrhoeae. In this study, we evaluated the abilities of the RIM-N carbohydrate degradation system (American MicroScan, Campbell, Calif.), the Gonochek II enzymatic identification system (Du Pont Co., Wilmington, Del.), and the Phadebact Gonococcus coagglutination test (Pharmacia Diagnostics, Piscataway, N.J.) to identify pathogenic Neisseria spp. and Branhamella catarrhalis. Both stock strains and clinical isolates, including 176 N. gonorrhoeae, 173 Neisseria meningitidis, 48 Neisseria lactamica, and 12 B. catarrhalis strains, were tested. The RIM-N identified 98% of the gonococci, 99% of the meningococci, 94% of the N. lactamica strains, and 100% of the B. catarrhalis strains within 1 h. The Gonochek II system identified 99% of the gonococci, 97% of the meningococci, 100% of the N. lactamica ...
https://www.meta.org/papers/evaluation-of-the-rim-n-gonochek-ii-and-phadebact/3889044
Defenses against oxidative stress in Neisseria gonorrhoeae and Neisseria meningitidis: distinctive systems for different...Defenses against oxidative stress in Neisseria gonorrhoeae and Neisseria meningitidis: distinctive systems for different...
Defenses against oxidative stress are crucial for the survival of the pathogens Neisseria meningitidis and Neisseria gonorrhoeae. An Mn(II) uptake system is involved in manganese (Mn)-dependent resistance to superoxide radicals in N. gonorrhoeae. Here, we show that accumulation of Mn also confers re …
https://pubmed.ncbi.nlm.nih.gov/15195253/?dopt=Abstract
KEGG PATHWAY: Methane metabolism - Neisseria gonorrhoeae FA 1090
Methane is metabolized principally by methanotrophs and methanogens in the global carbon cycle. Methanotrophs consume methane as the only source of carbon, while methanogens produce methane as a metabolic byproduct. Methylotrophs, which are microorganisms that can obtain energy for growth by oxidizing one-carbon compounds, such as methanol and methane, are situated between methanotrophs and methanogens. Methanogens can obtain energy for growth by converting a limited number of substrates to methane under anaerobic conditions. Three types of methanogenic pathways are known: CO2 to methane [MD:M00567], methanol to methane [MD:M00356], and acetate to methane [MD:M00357]. Methanogens use 2-mercaptoethanesulfonate (CoM; coenzyme M) as the terminal methyl carrier in methanogenesis and have four enzymes for CoM biosynthesis [MD:M00358]. Coenzyme B-Coenzyme M heterodisulfide reductase (Hdr), requiring for the final reaction steps of methanogenic pathway, is divided into two types: cytoplasmic HdrABC in ...
http://www.genome.jp/kegg-bin/show_pathway?ngo00680+NGO2020
Neisseria gonorrhoeae with Reduced Susceptibility to Azithromycin --- San Diego County, California, 2009Neisseria gonorrhoeae with Reduced Susceptibility to Azithromycin --- San Diego County, California, 2009
A single 2 g dose of azithromycin effectively treats genitourinary infections caused by susceptible Neisseria gonorrhoeae and has been used to treat uncomplicated gonorrhea in persons with cephalosporin allergy. However, azithromycin is not recommended as monotherapy because of concern over the emergence of resistance. Instead, a 1 g dose of azithromycin is recommended as a component of dual therapy for gonorrhea, in conjunction with a cephalosporin (i.e., 250 mg of ceftriaxone or 400 mg of cefixime, if ceftriaxone is not an option). During January 1992--July 2009, of 87,566 N. gonorrhoeae isolates tested for azithromycin susceptibility by CDCs national Gonoccoccal Isolate Surveillance Project (GISP), only 39 (0.04%) had minimum inhibitory concentrations (MICs) ≥8 µg/mL (including 25 with 8 µg/mL and 14 with 16 µg/mL), indicating reduced susceptibility; none of the isolates were collected in San Diego County, California (CDC, unpublished data, 2011). During August--October 2009, five of 55 ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6018a2.htm?s_cid=mm6018a2_w
STD Awareness: Genetics and the Gonococcus | Planned Parenthood Advocates of Arizona
Third, some gonococci are able to engage in conjugation, which is essentially bacteria sex! During conjugation, one bacterium uses an appendage called a sex pilus to attach to another bacterium and deliver a circular piece of DNA from the donor to the recipient. The recipient is now in possession of any traits its new DNA encodes.. You know how we humans are officially Homo sapiens? The scientific name for gonococci is Neisseria gonorrhoeae. And, just as we had genetic cousins in the form of Homo neanderthalensis (aka the Neanderthals), so too do Neisseria gonorrhoeae have cousins in the Neisseria genus. Most human-associated Neisseria species dont cause disease, and live peacefully in our upper respiratory tracts. These species include Neisseria flavescens, Neisseria flava, Neisseria perflava, Neisseria mucosa, Neisseria sicca, Neisseria polysaccharea, and more.. When gonococci meet their cousins at a family reunion, they dont swap recipes for potato salad - they swap genetic material. ...
http://advocatesaz.org/2015/07/27/std-awareness-genetics-and-the-gonococcus/
High-Level Ciprofloxacin Resistance in Neisseria gonorrhoeae: First Report from Israel - Volume 7, Number 1-February 2001 -...
To the Editor: We report a case of male gonococcal urethritis that persisted despite ciprofloxacin therapy. The isolate was found to be highly resistant (MIC 32 µg/mL).. A 30-year-old man visited his family physician with a 2-day history of urethral discharge and dysuria. The symptoms began 7 days after a single, unprotected orogenital contact with a female hitchhiker. The patient denied exchange of money for the act and reported no other recent sex partners or travel outside Israel. After a urethral swab was obtained for culture, the patient received a single dose of ciprofloxacin (500 mg orally). Growth of Neisseria gonorrhoeae was subsequently reported. However, symptoms persisted, and a regimen of doxycycline (100 mg orally twice daily for 10 days) was initiated. After temporary clinical improvement, the patient returned with worsening symptoms: bloody urethral discharge, severe dysuria, edema of the penis, and painful erection. N. gonorrhoeae was reisolated from a repeat urethral swab. ...
https://wwwnc.cdc.gov/eid/article/7/1/70-0158_article
The composition and metabolic phenotype of Neisseria gonorrhoeae biofilms - UQ eSpace
Neisseria gonorrhoeae has been shown to form biofilms during cervical infection. Thus, biofilm formation may play an important role in the infection of women. The ability of N. gonorrhoeae to form membrane blebs is crucial to biofilm formation. Blebs contain DNA and outer membrane structures, which have been shown to be major constituents of the biofilm matrix. The organism expresses a DNA thermonuclease that is involved in remodeling of the biofilm matrix. Comparison of the transcriptional profiles of gonococcal biofilms and planktonic runoff indicate that genes involved in anaerobic metabolism and oxidative stress tolerance are more highly expressed in biofilm. The expression of aniA, ccp, and norB, which encode nitrite reductase, cytochrome c peroxidase, and nitric oxide reductase respectively, is required for mature biofilm formation over glass and human cervical cells. In addition, anaerobic respiration occurs in the substratum of gonococcal biofilms and disruption of the norB gene required ...
https://espace.library.uq.edu.au/view/UQ:317082
Strong Positive Selection and Recombination Drive the Antigenic Variation of the PilE Protein of the Human Pathogen Neisseria...
TY - JOUR. T1 - Strong Positive Selection and Recombination Drive the Antigenic Variation of the PilE Protein of the Human Pathogen Neisseria meningitidis. AU - Andrews, T. Daniel. AU - Gojobori, Takashi. PY - 2004/1/1. Y1 - 2004/1/1. N2 - The PilE protein is the major component of the Neisseria meningitidis pilus, which is encoded by the pilE/pilS locus that includes an expressed gene and eight homologous silent fragments. The silent gene fragments have been shown to recombine through gene conversion with the expressed gene and thereby provide a means by which novel antigenic variants of the PilE protein can be generated. We have analyzed the evolutionary rate of the pilE gene using the nucleotide sequence of two complete pilE/pilS loci. The very high rate of evolution displayed by the PilE protein appears driven by both recombination and positive selection. Within the semivariable region of the pilE and pilS genes, recombination appears to occur within multiple small sequence blocks that lie ...
https://research.kaust.edu.sa/en/publications/strong-positive-selection-and-recombination-drive-the-antigenic-v
Genetic Resistance Determinants for Cefixime and Molecular Analysis of Gonococci Isolated in Italy<...
TY - JOUR. T1 - Genetic Resistance Determinants for Cefixime and Molecular Analysis of Gonococci Isolated in Italy. AU - Carannante, Anna. AU - Vacca, Paola. AU - Ghisetti, Valeria. AU - Latino, Maria Agnese. AU - Cusini, Marco. AU - Matteelli, Alberto. AU - Vocale, Caterina. AU - Prignano, Grazia. AU - Leli, Christian. AU - Ober, Patrizia. AU - Antonetti, Raffaele. AU - Poletti, Federica. AU - Stefanelli, Paola. PY - 2017/3. Y1 - 2017/3. N2 - A strictly defined subset of gonococci (n = 65) isolated in Italy from 2011 to 2014 was characterized by antimicrobial susceptibility for cefixime (CFM) and ceftriaxone (CRO) and by sequencing of resistance determinant genes (penA, mtrR, porB1b, ponA) for extended-spectrum cephalosporins and Neisseria gonorrhoeae multiantigen sequence typing (NG-MAST). The penA mosaic alleles XXXIV and XXXV were found in all resistant (R) and decreased susceptibility (DS) gonococci to CFM, except for one. They were associated with an adenine deletion in the mtrR promoter ...
https://moh-it.pure.elsevier.com/en/publications/genetic-resistance-determinants-for-cefixime-and-molecular-analys
MCQ on Neisseria gonorrhoeae and Neisseria meningitidis (Medical Microbiology)
9) About 10 to 20 percent of young children with severe meningococcal meningitis develop a syndrome called Waterhouse Friedrichsen syndrome, which one of these is not the symptomatic characteristic of this syndrome ...
https://www.medicalbiochemist.com/2019/01/neisseria-gonorrhoeae-mcq.html
Loop-Mediated Isothermal Amplification Test for Detection of Neisseria gonorrhoeae in Urine Samples and Tolerance of the Assay...Loop-Mediated Isothermal Amplification Test for Detection of Neisseria gonorrhoeae in Urine Samples and Tolerance of the Assay...
A loop-mediated isothermal amplification (LAMP) assay for open reading frame 1 (ORF1) of the glutamine synthetase gene of Neisseria gonorrhoeae was able to tolerate urea concentrations of ≤1.8 M, compared with a PCR assay that was functional at concentrations of ,100 mM. The LAMP assay was as sensitive as the PCR assay while being faster and simpler to perform.. ...
http://researchonline.ljmu.ac.uk/7560/
High-Throughput Screening for Novel Inhibitors of Neisseria gonorrhoeae Penicillin-Binding Protein 2High-Throughput Screening for Novel Inhibitors of Neisseria gonorrhoeae Penicillin-Binding Protein 2
The increasing prevalence of N. gonorrhoeae strains exhibiting decreased susceptibility to third-generation cephalosporins and the recent isolation of two distinct strains with high-level resistance to cefixime or ceftriaxone heralds the possible demise of β-lactam antibiotics as effective treatments for gonorrhea. To identify new compounds that inhibit penicillin-binding proteins (PBPs), which are proven targets for β-lactam antibiotics, we developed a high-throughput assay that uses fluorescence polarization (FP) to distinguish the fluorescent penicillin, Bocillin-FL, in free or PBP-bound form. This assay was used to screen a 50,000 compound library for potential inhibitors of N. gonorrhoeae PBP 2, and 32 compounds were identified that exhibited |50% inhibition of Bocillin-FL binding to PBP 2. These included a cephalosporin that provided validation of the assay. After elimination of compounds that failed to exhibit concentration-dependent inhibition, the antimicrobial activity of the remaining 24
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044918
neisseria gonorrhoeae | MICROBIOLOGY MATTERS !
Neisseria meningitidis is more classically known as the cause of meningococcal sepsis and meningococcal meningitis. However its role as a cause of urethritis/cervicitis has been the subject of ongoing speculation over the years, and several studies have backed such a link up. For example, check this study out, and this one.. A recent study has added more weight to this hypothesis, backing the assertion up with DNA studies of the N. meningitidis isolates showing adaptation to a genital environment. (loss of outer capsules, and acquisition of enzymes facilitating survival in a low oxygen environment). So what does this all mean for clinical microbiology laboratories?. I guess it shows the inherent weakness of molecular diagnosis. There could be a widespread outbreak of urethritis due to Neisseria meningitidis in your local area, but the laboratory would be completely naïve to it, if it only performs molecular testing for C. trachomatis and N. gonorrhoeae. Particularly in the Sexual Health Clinic ...
http://microbiologymatters.com/?tag=neisseria-gonorrhoeae
Failure Rate of Cefixime for N. gonorrhoeae Infection Explored - MPRFailure Rate of Cefixime for N. gonorrhoeae Infection Explored - MPR
For Neisseria gonorrhoeae (N. gonorrhoeae) infections, the rate of clinical treatment failure with cefixime is 6.77%, and is associated with minimum inhibitory concentrations (MICs) of ≥0.12µg/mL.
http://www.empr.com/news/failure-rate-of-cefixime-for-n-gonorrhoeae-infection-explored/article/275347/
Genetics of Chromosomally Mediated Intermediate Resistance to Ceftriaxone and Cefixime in Neisseria gonorrhoeae | Antimicrobial...Genetics of Chromosomally Mediated Intermediate Resistance to Ceftriaxone and Cefixime in Neisseria gonorrhoeae | Antimicrobial...
FIG. 3. Effects of deletion of the MtrC-MtrD-MtrE efflux pump or reversion of penB to the wild-type sequence in strains FA6140, FA6140 penA35, and 35/02 on the MICs of penicillin G, ceftriaxone, and cefixime. To investigate the individual contributions of mtrR and penB to Cephi, FA6140, FA6140 penA35, and 35/02 were transformed with plasmids harboring mtrD insertionally inactivated with a kanamycin resistance cassette or porB1b with a downstream erythromycin resistance cassette, and the MICs of the resulting transformants were determined as described in Materials and Methods. The MICs represent the averages ± standard deviations for at least two transformants in a minimum of three independent experiments. ...
https://aac.asm.org/content/53/9/3744/figures-only
Cefixime | Buy Online Usa | Все пресс-релизы - бесплатная публикация пресс-релизовCefixime | Buy Online Usa | Все пресс-релизы - бесплатная публикация пресс-релизов
Additionally, the most effective point with regards to a personal clinic is that it is preparing to make sure the confidentiality of an affected person, plus check outcomes are speedily decided. The strains of Neisseria gonorrhoeae are fast becoming resisted to Ceftriaxone and cefixime, which are very effective treatments for gonorrhea, but you are proofing being ineffective on these strains. Such people might opt for a medication for example Doxycycline, thats required to be taken for a long period. He also added that so far there are actually no reported treatment failures here inside U. Examples of Gram-positive bacteria include Staphylococcus, Streptococcus, Enterococcus, (that are cocci), and Bacillus, Corynebacterium, Nocardia, Clostridium, Actinobacteria, and Listeria (which can be rods). Currently the treatment for gonorrhea is either ceftriaxone (single dose injection) or cefixime (single dose oral). Due to their capacity to penetrate the central nervous sxstem, third-generation ...
http://p-release.ru/internet/cefixime-buy-online-usa
Demonstration by Light and Electron Microscopy of Capsules on Gonococci Recently Grown in vivo | Microbiology SocietyDemonstration by Light and Electron Microscopy of Capsules on Gonococci Recently Grown in vivo | Microbiology Society
A study by light microscopy, using Leishman's stain alone or Leishman's stain followed by nigrosin, showed the presence of capsules on gonococci of two strains subcultured from subcutaneous chambers in guinea pigs. With the Alcian blue method of preparation for electron microscopy, gonococci of both strains recently grown in vivo showed densely stained capsules on some cells, while others in the same preparation showed only irregular masses of dense material on their surfaces with strands connecting adjacent bacteria. Treatment with antiserum, complement and conglutinin revealed irregular masses and strands of extracellular material with fixatives that did not contain Alcian blue.
https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-106-1-81
subject:(neisseria gonorrhea) - OATDsubject:(neisseria gonorrhea) - OATD
Objectives Currently, ceftriaxone is the last remaining drug recommended for empirical treatment of gonorrhoea. Neisseria gonorrhoeae with reduced susceptibility to ceftriaxone have been isolated worldwide in countries such as Japan, France, Spain, Slovenia, Australia and Sweden. These have led to treatment failures and the emergence of ceftriaxone-resistant N. gonorrhoeae. Various mutations in penA (mosaic and nonmosaic), which encodes the penicillin-binding protein 2 (PBP2), have been reported to be the primary reason for reduced ceftriaxone susceptibility, but it can be reduced further by mutations in mtrR, porBIB and ponA. In this study, we aimed to determine the antimicrobial resistance patterns of New Zealand isolates of N. gonorrhoeae with reduced susceptibility to ceftriaxone and to characterise the penA, mtrR, porBIB and ponA in the isolates. Methods A total of 28 N. gonorrhoeae isolates with elevated ceftriaxone MIC (0.03 to 0.12 mg/L), collected from 2012 to 2015 and obtained from the ...
https://oatd.org/oatd/search?q=subject%3A%28neisseria%20gonorrhea%29&pagesize=30
Time to clearance of Chlamydia trachomatis RNA and DNA after treatment in patients coinfected with Neisseria gonorrhoeae - a...Time to clearance of Chlamydia trachomatis RNA and DNA after treatment in patients coinfected with Neisseria gonorrhoeae - a...
In this study we analysed the time to clearance of anogenital C. trachomatis after treatment in patients coinfected with N. gonorrhoeae, using modern RNA- and DNA-based NAATs and daily collected samples. The median time to clearance was 7 days for RNA and 6 days for DNA. Ninety-five per cent of patients had cleared C. trachomatis RNA and DNA after 13 and 14 days, respectively.. Several previous studies reported on in vivo clearance of C. trachomatis after treatment, but used different molecular testing methods, and a sampling frequency of no more than twice a week. Some studies observed clearance of DNA within 3 weeks using ligase chain reaction or in-house PCR methods [13, 14], while other studies reported 5-25 % DNA persistence after 3-4 weeks [9, 15, 16, 25]. The exact time to clearance of RNA, when tested by NAAT, was also previously unknown. Sena et al. reported 12 % RNA persistence after 4 weeks in men, while Dukers et al. reported 42 % intermittent positive results up to 51 days [9, 19]. ...
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-1878-3
lsog.org.lb
August 10, 2012 - The US Centers for Disease Control and Prevention (CDC) no longer recommends oral cephalosporin treatment for gonococcal infections, according to theirreported in the August 10 issue of theMorbidity and Mortality Weekly Report. The new recommendations update the CDCs 2010 Sexually Transmitted Diseases Treatment Guidelines. Infection with [Neisseria] gonorrhoeae is a major cause of pelvic inflammatory disease, ectopic pregnancy, and infertility, and can facilitate HIV transmission, write Carlos del Rio, MD, from the Rollins School of Public Health at Emory University in Atlanta, Georgia, and colleagues. In the United States, gonorrhea is the second most commonly reported notifiable infection, with ,300,000 cases reported during 2011. Gonorrhea treatment has been complicated by the ability ofN. gonorrhoeae to develop resistance to antimicrobials used for treatment. Urethral isolates of N gonorrhoeae collected in the United States during 2006 through 2011 have shown declining ...
http://pdfmedfinder.com/l/lsog.org.lb1.html
Thayer-Martin agar | definition of Thayer-Martin agar by Medical dictionaryThayer-Martin agar | definition of Thayer-Martin agar by Medical dictionary
Looking for online definition of Thayer-Martin agar in the Medical Dictionary? Thayer-Martin agar explanation free. What is Thayer-Martin agar? Meaning of Thayer-Martin agar medical term. What does Thayer-Martin agar mean?
http://medical-dictionary.thefreedictionary.com/Thayer-Martin+agar
Gonorrhoea test kit
Neisseria gonorrhoeae in female cervical swab and male urethral swab specimens. This kit is intended for use as an aid in the diagnosis of Gonorrhea. Principle:Gonorrhea is a sexually transmitted disease caused by the bacterium Neisseria gonorrhoeae. Gonorrhea is one of the most common infectious bacterial diseases and is most frequently transmitted during sexual intercourse,…
http://1099rdistributioncode7.xyz/gonorrhoea-test-kit/
A New Family of Secreted Toxins in Pathogenic Neisseria SpeciesA New Family of Secreted Toxins in Pathogenic Neisseria Species
Author Summary Many bacteria are able to secrete toxins targeted against neighboring cells. In order to protect themselves against their own toxin, they also express an
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004592
Notice to Readers: Discontinuation of SpectinomycinNotice to Readers: Discontinuation of Spectinomycin
In January 2006, CDC learned that Pfizer, Inc. (New York, New York) had discontinued U.S. distribution of spectinomycin (Trobicin®) in November 2005; remaining inventory will expire in May 2006. No other pharmaceutical company manufactures or sells spectinomycin in the United States. Pfizer is continuing to distribute spectinomycin outside the United States for the international market. CDC and the Food and Drug Administration are working with Pfizer to make spectinomycin available again in the United States and will update this information as soon as possible. Historically, spectinomycin has been used to treat persons infected with Neisseria gonorrhoeae who cannot receive one of the two first-line treatments (i.e., fluoroquinolones or third-generation cephalosporins) currently recommended for treatment of uncomplicated gonococcal infection (1). Relatively few indications exist for which spectinomycin is the preferred treatment option for N. gonorrhoeae; these include 1) pregnant women with ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5513a5.htm
Research | the Department of ImmunobiologyResearch | the Department of Immunobiology
The genus Neisseria contains many species. Most of them are part of the normal flora of humans and animals; only two are human pathogens: Neisseria gonorrhoeae, which causes a sexually transmitted disease of the same name, and Neisseria meningitidis, which causes meningitis. These pathogens often behave like their related commensal cousins in that they establish asymptomatic infection at high frequency. This commensal-like trait was likely inherited by the pathogens as they evolved from commensal species. Supporting this idea is the observation that many N. gonorrhoeae and N. meningiditis genes that mediate pathogen interactions with their hosts are also in the commensals. A major goal of our lab is to determine how commensal and pathogenic Neisseria differentially regulate these host interaction genes, and how these regulatory events might affect their lifecycle in the host.. Another goal of our lab is to use our new mouse model for Neisseria colonization, persistence, and asymptomatic ...
http://immunobiology.arizona.edu/research/so-lab/research
Self-Obtained Vaginal Swabs for Chlamydia and Gonorrhea Testing - Full Text View - ClinicalTrials.govSelf-Obtained Vaginal Swabs for Chlamydia and Gonorrhea Testing - Full Text View - ClinicalTrials.gov
To evaluate the agreement between NAAT results for Chlamydia trachomatis and Neisseria gonorrhoeae infection obtained with self-obtained vaginal swabs (SOVS), collected in a non-clinical setting vs. NAAT results using SOVS collected in a clinical setting. This is a new use of this specimen type as SOVS are FDA cleared only for use in clinics. The NAAT (Gen-Probe APTIMA Combo 2® Assay (AC2)) result with the home-collected SOVS specimen will be compared to the result obtained with an SOVS collected in the clinic on multiple platforms (Direct Tube Sampling (DTS) / Panther / Tigris). The term home-collected is used to refer to any specimen that is not collected in a clinic, since there is no certainty that a specimen is collected at home or in a restroom in an office setting, etc. To compare the SOVS results to an FDA cleared predicate test with the collection of two clinician collected vaginal swabs ...
https://clinicaltrials.gov/ct2/show/NCT01849653?recr=Open&cond=%22Gonorrhea%22&rank=4
What future treatment is recommended?
In 1998, Jones et al. determined that a new quinolone antibiotic, trovafloxacin, is highly active in vitro against uncomplicated gonorrhea, even against strains that showed mild resistance to ciprofloxacin and ofloxacin. It is also active against Chlamydia trachomatis, since many individuals with gonorrhea concurrently are infected with chlamydia, along with numerous other Gram positive and Gram negative bacteria. Jones et al. determined that these resistance phenotypes included ones that were pencillin-susceptible; chromosomally mediated resistance to pencillin and tetracycline; penicillinase-producing N. gonorrhoeae and those strains with plasmid-mediated resistance because of the TetM determinant; and plasmid-mediated resistance to tetracycline. As of 1999, no clinically significant resistance to the broad-spectrum cephalosporins have been identified, and fluoroquinolone-resistant gonococcal strains are now prevalent in Australia and much of the Far East (Fox and Knapp, 1999). Due to the ...
http://biology.kenyon.edu/slonc/bio38/stancikd_02/What_future_treatment_is_recommended.html
Increasing Trend of Resistance to Penicillin, Tetracycline, and Fluoroquinolone Resistance in Neisseria gonorrhoeae from...Increasing Trend of Resistance to Penicillin, Tetracycline, and Fluoroquinolone Resistance in Neisseria gonorrhoeae from...
Journal of Tropical Medicine is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of tropical diseases. Articles on the pathology, diagnosis, and treatment of tropical diseases, parasites and their hosts, epidemiology, and public health issues will be considered. Journal of Tropical Medicine aims to facilitate the communication of advances addressing global health and mortality relating to tropical diseases.
https://www.hindawi.com/journals/jtm/2011/960501/abs/
Neisseria gonorrhoeae Nucleic Acid by TMA - Covenant HealthCare Laboratory Test Directory
Specimens submitted with the white cleaning swab or with two swabs. Transport tubes without swabs. Swabs in gel, wooden swabs, dry swabs other than BD Dry Swab system. Swabs in bacterial transport medium (e.g., culturettes). Urine specimens where the liquid level in the urine transport tube does not fall between the two black indicator lines. Urine specimens in sterile containers that have exceeded the 24 hour stability. Specimens collected in liquid cytology containers or media will not be tested.. Specimens collected in Universal Transport Medium (UTM). ...
https://covenantlab.testcatalog.org/show/MISC1WARDEGCRNA-1
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We describe the results of the Quality Control for Molecular Diagnostics 2013 Neisseria gonorrhoeae external quality assessment programme that included an N. gonorrhoeae strain harbouring an N. meningitidis porA gene which causes false-negative results in molecular diagnostic assays targeting the gonococcal porA pseudogene. Enhanced awareness of the international transmission of such gonococcal strains is needed to avoid false-negative results in both in-house and commercial molecular diagnostic assays used in laboratories worldwide, but particularly in Europe.
http://www.eurosurveillance.org/content/10.2807/1560-7917.ES2014.19.8.20711
Martin Lewis Agar with Lincomycin, Pill Pocket - for Neisseria gonorrhoeae
Method of Use: Bring media to room temperature before use. Inoculate media by swabbing the surface from side to side while rolling in a large z pattern to sufficiently transfer the specimen. Remove the CO 2 generating tablet from the foil wrapper and immediately place the tablet into the circular well of the petri plate. The tablet will be activated by the moisture in the medium. Do not place a drop of water on the tablet. There is adequate moisture generated in the bag to slowly release the CO 2 . Place the plate in the ziplock bag and seal. The completeness of the seal is essential to maintain CO 2 environment for growth. Invert plates and incubate at 35ºC. for 24-48 hours. Some strains may require up to 72 hours to appear. If the plate is to be sent to a laboratory after inoculation, incubate them under appropriate conditions before shipment. Specimens should be submitted directly to the laboratory without delay and protected from excessive heat and cold. Specimens must be transported at ...
https://catalog.hardydiagnostics.com/cp_prod/Content/hugo/MartinLewisLincomycinPP.htm
Virulence factors of Neisseria gonorrhoeae Archives - Bacteriology Notes
I am Sagar Aryal, a passionate Microbiologist and the Scientific Blogger. I did my Masters Degree in Medical Microbiology and currently working as a Lecturer at Department of Microbiology, St. Xaviers College, Kathmandu, Nepal. I am particularly interested in research related to Medical Microbiology and Virology.. ...
http://bacteriologynotes.com/tag/virulence-factors-of-neisseria-gonorrhoeae/
Association of Neisseria gonorrhoeae OpaCEA with Dendritic Cells Suppresses Their Ability to Elicit an HIV-1-Specific T Cell...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
http://pubmedcentralcanada.ca/pmcc/articles/PMC3570455/?lang=en-ca
Gonococcal Infection of Anus and Rectum
Anorectal infection with Neisseria gonorrhoeae may follow appropriate sexual contact or secondary contamination. It is associated with proctitis,
https://www.health-portal.net/disease/alphabetically/index_eng.html?disease=98700
ASMscience | Gonorrhea
The purpose of this chapter is (i) to review the pathophysiology of gonorrhea during pregnancy, (ii) to summarize epidemiologic data regarding gonorrhea among pregnant women, and (iii) to discuss the manifestations of maternal and infant infections, with special emphasis on principles of prevention and management. Neisseria gonorrhoeae is a sexually transmitted bacterium which infects columnar and transitional epithelium of the genitourinary tract, including the urethra, endocervix, and anal canal, and the conjunctivae and pharynx. The majority of pregnant women with gonorrhea are asymptomatic; the proportion of symptomatic patients among pregnant women with gonorrhea has been reported to be as low as 1.2%. Pregnant women who are diagnosed with uncomplicated gonococcal infections or who are the sexual partners of men with gonorrhea should be treated with ceftriaxone (125 mg intramuscularly) in a single dose or with cefixime (400 mg orally) in a single dose. Due to the higher risk of pharyngeal gonorrhea
https://www.asmscience.org/content/book/10.1128/9781555818210.chap9
Efficacy of Combination Therapies for Gonorrhea Treatment - Full Text View - ClinicalTrials.govEfficacy of Combination Therapies for Gonorrhea Treatment - Full Text View - ClinicalTrials.gov
Infection with Neisseria (N.) gonorrhoeae carries a significant public health burden in the United States (U.S.). Gonococcal infection can result in pelvic inflammatory disease (PID), ectopic pregnancy, infertility, chronic pelvic pain, and increases the risk of transmission and acquisition of human immunodeficiency virus (HIV). With over 350,000 cases of gonorrhea reported each year, gonorrhea is the second most common notifiable condition. Furthermore, it is estimated that case reports account for only half of the incident cases of gonorrhea in the U.S. each year. Given that gonorrhea is a bacterial infection which causes symptoms in approximately 90 percent of infected men and 50 percent of infected women, the most critical aspect of reducing the public health burden of gonorrhea for affected populations is provision of effective antimicrobial therapy. In order to identify treatment options for patients with suspect or confirmed cephalosporin-resistant N. gonorrhoeae infection and patients ...
https://clinicaltrials.gov/ct2/show/NCT00926796?recr=Open&cond=%22Gonorrhea%22&rank=3
Fujibio Gonorrhea Test Kit - HIV Test Kit Philippines - HIV Testing at Home. 99.98% Accuracy with 100% Privacy.
Fujibio Gonorrhea Rapid Test Kit is a direct binding test for the visual detection of gonorrhea antigen , in the secretory specimen and urine from urogenital system, as an aid in the diagnosis of gonococcal infection. It is Based on the principle of double sandwich immunoassay for the detection of gonorrhea antigen in the secretory specimen or urine. Monoclonal and polyclonal antibodies are employed to identify gonorrhea specifically. Both sensitivity and specifically of the test are higher than those of the present methods, which often involve long hours of culturing the collected specimen. Test results are not affected by any medication that is being taken. Results are read visually without any instrumentation. This test is ideal for screening specimen samples containing at least 1x 10 bacteria per ml.. Gonorrhea or gonorrhea is a sexually transmitted disease (STD) that can infect both men and women which is caused by the bacterium Neisseria gonorrhoeae. It can cause infections in the ...
https://hivtestkit.ph/shop/fujibio-gonorrhea-test-kit/
Neisseria gonorrhoeaeNeisseria gonorrhoeae
Gonorrhea at eMedicine "Neisseria gonorrhoeae". NCBI Taxonomy Browser. 485. Type strain of Neisseria gonorrhoeae at BacDive - ... Neisseria gonorrhoeae is named for Albert Neisser, who isolated it as the causative agent of the disease gonorrhea in 1878. ... "Neisseria gonorrhoeae genome statistics". Broad Institute. Retrieved 8 April 2017. Chung, G. T.; Yoo, J. S.; Oh, H. B.; Lee, Y ... Neisseria gonorrhoeae, also known as gonococcus (singular), or gonococci (plural), is a species of Gram-negative diplococci ...
https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae
Antibiotic resistance in gonorrheaAntibiotic resistance in gonorrhea
Neisseria gonorrhoeae Antibiotic resistance Ligon BL (2005). "Albert Ludwig Sigesmund Neisser: discoverer of the cause of ... Neisseria gonorrhoeae, the bacterium that causes the sexually transmitted infection gonorrhea, has developed antibiotic ... Deguchi T, Nakane K, Yasuda M, Maeda S (September 2010). "Emergence and spread of drug resistant Neisseria gonorrhoeae". J. ... Print Rouquette-Loughlin, Dunham, Kuhn, Balthazar, Shafer (2003) The NorM Efflux Pump of Neisseria gonorrhoeae and Neissera ...
https://en.wikipedia.org/wiki/Antibiotic_resistance_in_gonorrhea
OfloxacinOfloxacin
Knapp JS, Fox KK, Trees DL, Whittington WL (1997). "Fluoroquinolone resistance in Neisseria gonorrhoeae". Emerg. Infect. Dis. 3 ... Enterobacter aerogenes Escherichia coli Haemophilus influenzae Klebsiella pneumoniae Neisseria gonorrhoeae Proteus mirabilis ...
https://en.wikipedia.org/wiki/Ofloxacin
Bacterial adhesinBacterial adhesin
... characterizes Neisseria gonorrhoeae infections. Additionally, recent studies out of Stockholm have shown that Neisseria can ... Davies, J. K.; Koomey, J. M.; Seifert, H. S. (1994). "Pili (fimbriae) of Neisseria gonorrhoeae". In Klemm, Per (ed.). Fimbriae ... as is the case in Neisseria gonorrhoeae). Despite these challenges, progress is being made in the creation of anti-adhesion ... N. gonorrhoeae is host restricted almost entirely to humans. "Extensive studies have established type 4 fimbrial adhesins of N ...
https://en.wikipedia.org/wiki/Bacterial_adhesin
Fastidious organismFastidious organism
Neisseria gonorrhoeae, the Gonococcus, and Gonorrhea. Archived 2013-01-19 at the Wayback Machine Lectures in Microbiology. 2009 ... An example of a fastidious bacterium is Neisseria gonorrhoeae, which requires blood or hemoglobin and several amino acids and ...
https://en.wikipedia.org/wiki/Fastidious_organism
Pelvic inflammatory diseasePelvic inflammatory disease
Infections by Neisseria gonorrhoeae or Chlamydia trachomatis are present in 75 to 90 percent of cases. Often, multiple ... Chlamydia trachomatis Neisseria gonorrhoeae Prevotella spp. Streptococcus pyogenes Prevotella bivia Prevotella disiens ... Chlamydia trachomatis and Neisseria gonorrhoeae are usually the main cause of PID. Data suggest that PID is often polymicrobial ... N. gonorrhoeae has been isolated from fallopian tubes, facultative and anaerobic organisms were recovered from endometrial ...
https://en.wikipedia.org/wiki/Pelvic_inflammatory_disease
GonorrheaGonorrhea
... is caused by the bacterium Neisseria gonorrhoeae. Previous infection does not confer immunity - a person who has been ... Deguchi T, Nakane K, Yasuda M, Maeda S (September 2010). "Emergence and spread of drug resistant Neisseria gonorrhoeae". J. ... Ng, Lai-King; Martin, Irene E (2005). "The laboratory diagnosis of Neisseria gonorrhoeae". The Canadian Journal of Infectious ... cite journal}}: ,first1= has generic name (help) Emergence of multi-drug resistant Neisseria gonorrhoeae (PDF) (Report). World ...
https://en.wikipedia.org/wiki/Gonorrhea
ProtegrinProtegrin
Qu XD, Harwig SS, Oren AM, Shafer WM, Lehrer RI (April 1996). "Susceptibility of Neisseria gonorrhoeae to protegrins". ... Neisseria gonorrhoeae, and the virions of the human immunodeficiency virus in vitro under conditions which mimic the tonicity ...
https://en.wikipedia.org/wiki/Protegrin
Povidone-iodinePovidone-iodine
Martin I, Sawatzky P, Liu G, Mulvey MR (February 2015). "Neisseria gonorrhoeae in Canada: 2009-2013". Canada Communicable ... especially if it is caused by Neisseria gonorrhoeae, or Chlamydia trachomatis. It is currently unclear whether PVP-I is more ...
https://en.wikipedia.org/wiki/Povidone-iodine
Rectal dischargeRectal discharge
Rectal gonorrhea is caused by Neisseria gonorrhoeae. The condition is usually asymptomatic, but symptoms can include rectal ...
https://en.wikipedia.org/wiki/Rectal_discharge
TonsillitisTonsillitis
Rarely bacteria such as Neisseria gonorrhoeae, Corynebacterium diphtheriae, or Haemophilus influenzae may be the cause. ... and Neisseria gonorrhoeae. Anaerobic bacteria have been implicated in tonsillitis, and a possible role in the acute ...
https://en.wikipedia.org/wiki/Tonsillitis
James Howard BrownJames Howard Brown
Koch, Marie L. (1949). "A Transparent Agar Medium for Growing Neisseria Gonorrhoeae". Journal of Bacteriology. 57 (5): 574. doi ...
https://en.wikipedia.org/wiki/James_Howard_Brown
DNA replicationDNA replication
Tobiason DM, Seifert HS (June 2006). "The obligate human pathogen, Neisseria gonorrhoeae, is polyploid". PLOS Biology. 4 (6): ...
https://en.wikipedia.org/wiki/DNA_replication
Vaginal floraVaginal flora
Graver MA, Wade JJ (February 2011). "The role of acidification in the inhibition of Neisseria gonorrhoeae by vaginal ... Neisseria gonorrhoeae, Peptostreptococcus anaerobius, Prevotella bivia and Staphylococcus aureus. It is generally accepted that ...
https://en.wikipedia.org/wiki/Vaginal_flora
Alpha-D-phosphohexomutase superfamilyAlpha-D-phosphohexomutase superfamily
Sandlin RC, Stein DC (May 1994). "Role of phosphoglucomutase in lipooligosaccharide biosynthesis in Neisseria gonorrhoeae". ... "Phase-variation of the truncated lipo-oligosaccharide of Neisseria meningitidis NMB phosphoglucomutase isogenic mutant NMB-R6 ... "Lipooligosaccharide biosynthesis in pathogenic Neisseria. Cloning, identification, and characterization of the ...
https://en.wikipedia.org/wiki/Alpha-D-phosphohexomutase_superfamily
3-dehydroquinate synthase3-dehydroquinate synthase
Barten R, Meyer TF (April 1998). "Cloning and characterisation of the Neisseria gonorrhoeae aroB gene". Molecular & General ...
https://en.wikipedia.org/wiki/3-dehydroquinate_synthase
Anaerobic infectionAnaerobic infection
including groups A and B), Neisseria gonorrhoeae, Chlamydia spp. and Mycoplasma hominis. Free gas in the tissues, abscess ...
https://en.wikipedia.org/wiki/Anaerobic_infection
QRNGQRNG
... a function that generates a series of numbers that fill some range in an even pattern Quinolone-resistant neisseria gonorrhoeae ... "Increasing rates of quinolone-resistant Neisseria gonorrhoeae in Paris, France". Journal of the European Academy of Dermatology ...
https://en.wikipedia.org/wiki/QRNG
NeutrophilNeutrophil
Chlamydia pneumoniae and Neisseria gonorrhoeae have been reported to delay neutrophil apoptosis. Thus, some bacteria - and ... Simons MP, Nauseef WM, Griffith TS, Apicella MA (November 2006). "Neisseria gonorrhoeae delays the onset of apoptosis in ... Chen A, Seifert HS (November 2011). "Neisseria gonorrhoeae-mediated inhibition of apoptotic signalling in polymorphonuclear ...
https://en.wikipedia.org/wiki/Neutrophil
PyomyositisPyomyositis
Jensen M (2021). "Neisseria gonorrhoeae pyomyositis complicated by compartment syndrome: A rare manifestation of disseminated ... Gonococcal pyomyositis is a rare infection caused by Neisseria gonorrhoeae. CT with IV contrast showing enlargement and ...
https://en.wikipedia.org/wiki/Pyomyositis
InflammasomeInflammasome
May 2009). "Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC ... Neisseria gonorrhoeae, and bacterial toxins e.g. nigericin and maitotoxin. All NLRP3 activators induce cytosolic potassium ...
https://en.wikipedia.org/wiki/Inflammasome
Autotransporter familyAutotransporter family
This secretion pathway is exemplified by the prototypical IgA1 Protease of Neisseria gonorrhoeae. The protein is directed to ... Pohlner J, Halter R, Beyreuther K, Meyer TF (1987). "Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA ...
https://en.wikipedia.org/wiki/Autotransporter_family
Terminalia macropteraTerminalia macroptera
Silva O, Ferreira E, Pato M, Caniça M, Gomes ET (2002). "In vitro anti-Neisseria gonorrhoeae activity of Terminalia macroptera ... Extracts of the plant have shown activity against Helicobacter pylori and Neisseria gonorrhoeae. Parts of the plant are also ...
https://en.wikipedia.org/wiki/Terminalia_macroptera
ORFeomeORFeome
Neisseria gonorrhoeae,Pseudomonas aeruginosa, Schizosaccharomyces pombe, Staphylococcus aureus and human herpesviruses A ... "Expression capable library for studies of Neisseria gonorrhoeae, version 1.0". BMC Microbiology. 5: 50. doi:10.1186/1471-2180-5 ...
https://en.wikipedia.org/wiki/ORFeome
ZabofloxacinZabofloxacin
It also has activity against Neisseria gonorrhoeae including strains that are resistant to other quinolone antibiotics. ... Jones RN, Biedenbach DJ, Ambrose PG, Wikler MA (2008). "Zabofloxacin (DW-224a) activity against Neisseria gonorrhoeae including ...
https://en.wikipedia.org/wiki/Zabofloxacin
Antimicrobial resistanceAntimicrobial resistance
Penicillinase-producing Neisseria gonorrhoeae developed a resistance to penicillin in 1976. Another example is Azithromycin- ... resistant Neisseria gonorrhoeae, which developed a resistance to azithromycin in 2011. In gram-negative bacteria, plasmid- ...
https://en.wikipedia.org/wiki/Antimicrobial_resistance
Discovery and development of cephalosporinsDiscovery and development of cephalosporins
For example, the binding site of PBP2 in Neisseria gonorrhoeae has been structurally determined and has three sequence motifs ... Spratt, Brian G. (10 March 1988). "Hybrid penicillin-binding proteins in penicillin-resistant strains of Neisseria gonorrhoeae ... resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance". Journal of ...
https://en.wikipedia.org/wiki/Discovery_and_development_of_cephalosporins
Neisseria cinereaNeisseria cinerea
Using DNA hybridization, N. cinerea exhibits 50% similarity to Neisseria gonorrhoeae. Neisseria cinerea has been formerly ... Neisseria cinerea can produce acid from glucose like N. gonorrhoeae, but it will then oxidize the acid to carbon dioxide. ... "Neisseria cinerea" at the Encyclopedia of Life Type strain of Neisseria cinerea at BacDive - the Bacterial Diversity ... Knapp, J.S.; E.W. Hook (1988). "Prevalence and persistence of Neisseria cinerea and other Neisseria spp. in adults". Journal of ...
https://en.wikipedia.org/wiki/Neisseria_cinerea
RecARecA
Neisseria gonorrhoeae, Hemophilus influenzae, Streptococcus pneumoniae, Streptococcus mutans and Helicobacter pylori). In the ...
https://en.wikipedia.org/wiki/RecA
GonococcemiaGonococcemia
Neisseria gonorrhoeae is a gram negative diplococcus (also referred to as "Gonococcus") and a pathogenic bacteria. In 2019, ... Neisseria gonorrhoeae is transmitted during sexual contact with an infected individual. The bacteria invade the non-ciliated ... Bacterial resistance to antibiotics is increasingly common in Neisseria gonorrhoeae, so it is often advised to check ... Risk factors include female sex, sexual promiscuity, and infection with resistant strains of Neisseria gonorrhoeae. This ...
https://en.wikipedia.org/wiki/Gonococcemia
Fitz-Hugh-Curtis syndromeFitz-Hugh-Curtis syndrome
It is usually caused by Chlamydia trachomatis (Chlamydia) or Neisseria gonorrhoeae (Gonorrhea) though other bacteria such as ...
https://en.wikipedia.org/wiki/Fitz-Hugh–Curtis_syndrome
CoccusCoccus
Streptococcus pneumoniae and Neisseria gonorrhoeae) Streptococci are chains of cocci (e.g. Streptococcus pyogenes). ...
https://en.wikipedia.org/wiki/Coccus
Neonatal conjunctivitisNeonatal conjunctivitis
Right after delivery Neisseria gonorrhoeae: Delivery of the baby until 5 days after birth (early onset) Chlamydia trachomatis: ... most commonly Neisseria gonorrhoeae or Chlamydia trachomatis. Antibiotic ointment is typically applied to the newborn's eyes ... gonorrhoeae) typically manifests in the first 5 days after birth and is associated with marked bilateral purulent discharge and ...
https://en.wikipedia.org/wiki/Neonatal_conjunctivitis
History of human sexualityHistory of human sexuality
Baarda, Benjamin I.; Sikora, Aleksandra E. (2015). "Proteomics of Neisseria gonorrhoeae: the treasure hunt for countermeasures ... Prostitution has been described as the "world's oldest profession". Gonorrhoeae is recorded at least up to 700 years ago and ...
https://en.wikipedia.org/wiki/History_of_human_sexuality
Cefuroxime axetilCefuroxime axetil
Gram-negative aerobic microorganisms Haemophilus influenzae Moraxella catarrhalis Neisseria gonorrhoeae Escherichia coli ...
https://en.wikipedia.org/wiki/Cefuroxime_axetil
SpermatoceleSpermatocele
... and urine nucleic acid amplification tests for presence of Neisseria gonorrhoeae and Chlamydia trachomatis. Management of ...
https://en.wikipedia.org/wiki/Spermatocele
Pamela TolimanPamela Toliman
Neisseria gonorrhoeae isolates from four centres in Papua New Guinea remain susceptible to amoxycillin-clavulanate therapy. ...
https://en.wikipedia.org/wiki/Pamela_Toliman
Septic arthritisSeptic arthritis
Gonococcal arthritis - Neisseria gonorrhoeae is a common cause of septic arthritis in people who are sexually active and under ... a common cause in infants Haemophilus influenzae Neisseria gonorrhoeae - the most common cause of septic arthritis in young, ... Neisseria meningitidis Escherichia coli - in the elderly, IV drug users and the seriously ill Pseudomonas aeruginosa - IV drug ... This can include NAAT testing for N. gonorrhoeae if suspected in a sexually active person. In children, the Kocher criteria is ...
https://en.wikipedia.org/wiki/Septic_arthritis
ProctocolitisProctocolitis
Common infectious causes of proctocolitis include Chlamydia trachomatis, LGV (Lymphogranuloma venereum), Neisseria gonorrhoeae ...
https://en.wikipedia.org/wiki/Proctocolitis
CefotaximeCefotaxime
... pyogenes Escherichia coli Haemophilus influenzae Neisseria gonorrhoeae and N. meningitidis Klebsiella spp. Burkholderia cepacia ...
https://en.wikipedia.org/wiki/Cefotaxime
EndometritisEndometritis
The most common organisms are Chlamydia trachomatis (chlamydia), Neisseria gonorrhoeae (gonorrhea), Streptococcus agalactiae ( ...
https://en.wikipedia.org/wiki/Endometritis
Kalai MatheeKalai Mathee
... and completed her master's in molecular genetics focusing on Neisseria gonorrhoeae in 1986 under the tutelage of Chong-Lek Koh ...
https://en.wikipedia.org/wiki/Kalai_Mathee
New York City agarNew York City agar
The NYC (New York City) medium or GC (Neisseria gonorrhoeae) medium agar is used for isolating Gonococci. The agar base is ... Also, presence of yeast autolysate reduces the lag phase of growth of Neisseria, thus enhancing both size and number of ... Typical colonial morphology is as follows: N. gonorrhoeae may appear as small (0.5-1.0 mm) grayish white to colorless mucoid ... This medium is superior to other media generally employed for the isolation of Neisseria species. The transparent nature of the ...
https://en.wikipedia.org/wiki/New_York_City_agar
Uptake signal sequenceUptake signal sequence
... including Neisseria meningitidis and Neisseria gonorrhoeae). Genetic transformation is the process by which a recipient ...
https://en.wikipedia.org/wiki/Uptake_signal_sequence
BenzylpenicillinBenzylpenicillin
Some gram-negative organisms such as Neisseria gonorrhoeae and Leptospira weilii are also reported to be susceptible to ...
https://en.wikipedia.org/wiki/Benzylpenicillin
Twitching motilityTwitching motility
It has been observed in many bacterial species, but is most well studied in Pseudomonas aeruginosa, Neisseria gonorrhoeae and ... Most well studied and wide spread are the twitching Pseudomonadota, such as Neisseria gonorrhoeae, Myxococcus xanthus and ... In N. gonorrhoeae for example, the roughly spherical cell shape and uniform distribution of pili results in cells adopting a 2D ...
https://en.wikipedia.org/wiki/Twitching_motility
MezlocillinMezlocillin
Escherichia coli Haemophilus influenzae Klebsiella species Morganella morganii Neisseria gonorrhoeae Proteus mirabilis Proteus ...
https://en.wikipedia.org/wiki/Mezlocillin
International Pathogenic Neisseria ConferenceInternational Pathogenic Neisseria Conference
This includes immunology, vaccinology and physiology and metabolism of Neisseria meningitidis, Neisseria gonorrhoeae and the ... "IPNC - Neisseria.org". neisseria.org/ipnc/. Retrieved 2018-08-02. "IPNC - Neisseria.org". neisseria.org. Retrieved 2015-06-14 ... "The Igor Stojiljkovic Memorial Fund - Neisseria.org". neisseria.org. Retrieved 2015-06-14. IPNC IPNC 2016 (Articles with VIAF ... The International Pathogenic Neisseria Conference (IPNC) occurs every two years and is a forum for the presentation of cutting- ...
https://en.wikipedia.org/wiki/International_Pathogenic_Neisseria_Conference
Subclinical infectionSubclinical infection
Neisseria gonorrhoeae (gonorrhoea) Neisseria meningitidis (Meningitis) nontyphoidal Salmonella noroviruses Poliovirus ( ... "Features of Chlamydia trachomatis and Neisseria gonorrhoeae Infection in Male Army Recruits". The Journal of Infectious ... Yazdankhah SP, Caugant DA (September 2004). "Neisseria meningitidis: an overview of the carriage state". J. Med. Microbiol. 53 ...
https://en.wikipedia.org/wiki/Subclinical_infection
Sexually transmitted infectionSexually transmitted infection
Baarda BI, Sikora AE (2015). "Proteomics of Neisseria gonorrhoeae: the treasure hunt for countermeasures against an old disease ... Chancroid (Haemophilus ducreyi) Chlamydia (Chlamydia trachomatis) Gonorrhea (Neisseria gonorrhoeae) Granuloma inguinale or ( ...
https://en.wikipedia.org/wiki/Sexually_transmitted_infection
EravacyclineEravacycline
Acinetobacter baumannii Stenotrophomonas maltophilia Haemophilus influenzae Moraxella catarrhalis Neisseria gonorrhoeae ...
https://en.wikipedia.org/wiki/Eravacycline
VaginitisVaginitis
Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, herpes simplex virus, and human papillomavirus). Symptoms ...
https://en.wikipedia.org/wiki/Vaginitis
Browsing Meeting reports by Subject Neisseria gonorrhoeaeBrowsing Meeting reports by Subject "Neisseria gonorrhoeae"
Response to the Threat of Untreatable Neisseria Gonorrhoeae and Emergence of Cephalosporin Resistance in Neisseria Gonorrhoeae ... Browsing Meeting reports by Subject "Neisseria gonorrhoeae". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U ...
https://apps.who.int/iris/handle/10665/197911/browse?authority=Neisseria+gonorrhoeae&type=mesh
Parcourir par sujet NEISSERIA GONORRHOEAEParcourir par sujet "NEISSERIA GONORRHOEAE"
Response to the Threat of Untreatable Neisseria Gonorrhoeae and Emergence of Cephalosporin Resistance in Neisseria Gonorrhoeae ... Neisseria meningitidis, Streptococcus pneumoniae, Neisseria gonorrhoeae, Salmonella serotipo Typhi, Shigella y Vibrio cholerae ... Neisseria gonorrhoeae et les infections gonococciques : rapport d un groupe scientifique de l OMS [‎réuni à Genève du 2 au ... Antimicrobial resistance in Neisseria gonorrhoeae / John Tapsall  Tapsall, John; World Health Organization. Anti-Infective ...
https://extranet.who.int/iris/restricted/browse?locale-attribute=fr&type=mesh&authority=Neisseria+gonorrhoeae
Fluoroquinolone-Resistant Neisseria gonorrhoeae -- San Diego, California, 1997Fluoroquinolone-Resistant Neisseria gonorrhoeae -- San Diego, California, 1997
... MMWR 47(20);405-8 Publication date: 05/29/1998. ... Decreased susceptibility of Neisseria gonorrhoeae to fluoroquinolones -- Ohio and Hawaii, 1992-1993. MMWR 1994;43:325-7. * Fox ... Antimicrobial resistance in Neisseria gonorrhoeae in the United States, 1988-1994: the emergence of decreased susceptibility to ... Fluoroquinolone resistance in Neisseria gonorrhoeae -- Colorado and Washington, 1995. MMWR 1995;44:761-4. * CDC. ...
https://wonder.cdc.gov/wonder/prevguid/m0053026/m0053026.asp
Neisseria gonorrhoeae AUSMDU00010541
Gonorrhea (Neisseria gonorrhoeae) | Wisconsin Department of Health ServicesGonorrhea (Neisseria gonorrhoeae) | Wisconsin Department of Health Services
Gonorrhea (Neisseria gonorrhoeae) Assigned Number Title. Version Date Publication Type Other Location Language ... Gonorrhea (Neisseria gonorrhoeae) August 1, 2019 PDF None English P-42048 Gonorrhea (Neisseria gonorrhoeae), Hmong August 1, ...
https://www.dhs.wisconsin.gov/library/P-42048.htm
View source for Neisseria gonorrhoeae - microbewiki
http://www.ebi.ac.uk/2can/genomes/bacteria/Neisseria_gonorrhoeae.html a. "Neisseria gonorrhoeae causes Gonorrhea" European ... Neisseria gonorrhoeae also have a well-developed iron acquisition system that allows it to extract iron from its host during ... 8]. Neisseria gonorrhoeae is only found after sexual contact with an infected person (or direct contact, in the case of ... 10] In women, Neisseria gonorrhoeae primarily infects the cervix in women. The symptoms of gonorrhea are often mild and most ...
https://microbewiki.kenyon.edu/index.php?title=Neisseria_gonorrhoeae&action=edit&oldid=25183
Resistance or Elevated Minimum Inhibitory Concentration (MIC) Patterns of Neisseria gonorrhoeae Isolates to Antimicrobials,...Resistance or Elevated Minimum Inhibitory Concentration (MIC) Patterns of Neisseria gonorrhoeae Isolates to Antimicrobials,...
Resistance or Elevated Minimum Inhibitory Concentration (MIC) Patterns of Neisseria gonorrhoeae Isolates to Antimicrobials, ...
https://www.cdc.gov/std/statistics/2019/figures/GISP-2.htm
Increases in fluoroquinolone-resistant Neisseria gonorrhoeae among men who have sex with men--United States, 2003, and revised...Increases in fluoroquinolone-resistant Neisseria gonorrhoeae among men who have sex with men--United States, 2003, and revised...
... an estimated 700,000-800,000 persons are infected with Neisseria gonorrhoeae each year. Since 1993, CDC has recommended use of ... In the United States, an estimated 700,000-800,000 persons are infected with Neisseria gonorrhoeae each year. Since 1993, CDC ... Increases in fluoroquinolone-resistant Neisseria gonorrhoeae among men who have sex with men--United States, 2003, and revised ... However, because of increased prevalence of fluoroquinolone-resistant N. gonorrhoeae (QRNG) in Asia, the Pacific Islands ( ...
https://pubmed.ncbi.nlm.nih.gov/15123985/?dopt=Abstract
Neisseria gonorrhoeae Resistant to Ceftriaxone and Cefixime, Argentina - Volume 22, Number 6-June 2016 - Emerging Infectious...
Ohnishi M, Golparian D, Shimuta K, Saika T, Hoshina S, Iwasaku K, Is Neisseria gonorrhoeae initiating a future era of ... Whiley DM, Goire N, Lambert SB, Ray S, Limnios EA, Nissen MD, Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is ... Neisseria gonorrhoeae Resistant to Ceftriaxone and Cefixime, Argentina. Emerging Infectious Diseases. 2016;22(6):1139-1141. doi ... Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and ...
https://wwwnc.cdc.gov/eid/article/22/6/15-2091_article
Molecular Regulatory Mechanisms Drive Emergent Pathogenetic Properties of Neisseria gonorrhoeae | PNNLMolecular Regulatory Mechanisms Drive Emergent Pathogenetic Properties of Neisseria gonorrhoeae | PNNL
Neisseria gonorrhoeae is the causative agent of the sexually transmitted infection (STI) gonorrhea, with an estimated 87 ... 2022. Molecular Regulatory Mechanisms Drive Emergent Pathogenetic Properties of Neisseria gonorrhoeae. Microorganisms 10, no. 5 ... N. gonorrhoeae predominantly colonizes the male and female genital tract (FGT). In the FGT, N. gonorrhoeae confronts ... One mechanism utilized by N. gonorrhoeae to adapt to this dynamic FGT niche is to modulate gene expression primarily through ...
https://www.pnnl.gov/publications/molecular-regulatory-mechanisms-drive-emergent-pathogenetic-properties-neisseria
What are the cultural and biochemical tests for Neisseria gonorrhoeae?<...What are the cultural and biochemical tests for Neisseria gonorrhoeae?<...
What are the cultural and biochemical tests for Neisseria gonorrhoeae?. Many methods for the characterization of N gonorrhoeae ... What are the cultural and biochemical tests for Neisseria gonorrhoeae?. January 3, 2020. by Rhyley Bryan ... How do you test for Neisseria?. Urogenital N. gonorrhoeae infections can be diagnosed using culture or nonculture (e.g., the ... Gonochek II is a tube test that is designed to differentiate between Neisseria lactamica, N. meningitidis, N. gonorrhoeae and ...
https://www.handlebar-online.com/other/what-are-the-cultural-and-biochemical-tests-for-neisseria-gonorrhoeae/
Seminal Plasma Initiates a Neisseria gonorrhoeae Transmission State - Kölner UniversitätsPublikationsServerSeminal Plasma Initiates a Neisseria gonorrhoeae Transmission State - Kölner UniversitätsPublikationsServer
Neisseria gonorrhoeae causes the genital infection gonorrhea and is exposed to seminal fluid during sexual transmission. ... Seminal Plasma Initiates a Neisseria gonorrhoeae Transmission State. mBio, 5 (2). WASHINGTON: AMER SOC MICROBIOLOGY. ISSN 2150- ... Research characterizing the mechanisms of pathogenesis and transmission of Neisseria gonorrhoeae is important for developing ... Treatment of N. gonorrhoeae with seminal plasma or purified semen proteins lactoferrin, serum albumin, and prostate-specific ...
https://kups.ub.uni-koeln.de/44394/
Chlamydia trachomatis, Neisseria gonorrhoeae and syphilis among men who have sex with men in Brazil | BMC Public Health | Full...Chlamydia trachomatis, Neisseria gonorrhoeae and syphilis among men who have sex with men in Brazil | BMC Public Health | Full...
We aimed to assess the prevalence of rectal and urethral Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections ... From: Chlamydia trachomatis, Neisseria gonorrhoeae and syphilis among men who have sex with men in Brazil ...
https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-015-2002-0/tables/2
Neisseria gonorrhoeaeNeisseria gonorrhoeae
... : Drug Resistant Gonorrhea. Gonorrhea is a sexually transmitted disease (STD) caused by infection with the ... Neisseria gonorrhoeae is a Gram negative, diplococcus shaped bacterium, that only colonizes humans. It is never present in ... N. gonorrhoeae infections start by the bacteria attaching to epithelial cells. The bacteria then penetrates the cell and ... N. gonorrhoeae infects and grows rapidly in mucous membranes, especially in the reproductive tract (cervix, uterus, fallopian ...
https://medschool.ucsd.edu/som/pediatrics/Divisions/host-microbe-systems/CHARM/challenge/Pages/NG.aspx
A systematic review and appraisal of the quality of practice guidelines for the management of Neisseria gonorrhoeae infections ...
Direct detection of markers associated with Neisseria gonorrhoeae antimicrobial resistance in New Zealand using residual DNA...Direct detection of markers associated with Neisseria gonorrhoeae antimicrobial resistance in New Zealand using residual DNA...
Direct detection of markers associated with Neisseria gonorrhoeae antimicrobial resistance in New Zealand using residual DNA ... Direct detection of markers associated with Neisseria gonorrhoeae antimicrobial resistance in New Zealand using residual DNA ... in non-cultured clinical samples to enhance surveillance of Neisseria gonorrhoeae AMR in New Zealand. ... Overall, the results further highlight the potential of molecular methods to aid N. gonorrhoeae AMR surveillance, particularly ...
https://sti.bmj.com/content/91/2/91?ijkey=086b0c6b27c4ee5c6db110be7c94e02a4c0ede2f&keytype2=tf_ipsecsha
Department of Health and Aged Care | Surveillance of antibiotic resistance in <em>Neisseria gonorrhoeae</em> in the WHO Western...Department of Health and Aged Care | Surveillance of antibiotic resistance in <em>Neisseria gonorrhoeae</em> in the WHO Western...
Palmer HM, Young H, Winter A, Dave J. Emergence and spread of azithromycin-resistant Neisseria gonorrhoeae in Scotland. J ... 3. Bala M, Ray K, Kumari S. Alarming increase in ciprofloxacin and penicillin resistant Neisseria gonorrhoeae isolates in New ... Mosaic-like structure of penicillin-binding protein 2 Gene (penA) in clinical isolates of Neisseria gonorrhoeae with reduced ... Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific Region, 2006. Commun Dis Intell 2008( ...
https://www1.health.gov.au/internet/main/publishing.nsf/Content/cda-cdi3401a.htm
Triple co-culture and perfusion bioreactor for studying the interaction between Neisseria gonorrhoeae and neutrophils: A novel...Triple co-culture and perfusion bioreactor for studying the interaction between Neisseria gonorrhoeae and neutrophils: A novel...
Therefore, proper modeling of the N. gonorrhoeae interaction with neutrophils is very important for investigating and ... gonorrhoeae, we introduced primary human neutrophils to the endothelial side of the model using a perfusion-based bioreactor ... gonorrhoeae infection. The triple co-culture model consisted of epithelial cells (T84 human colorectal carcinoma cells), human ... gonorrhoeae and other bacterial infections and interactions with the innate immunity cells under conditions closely resembling ...
https://publica.fraunhofer.de/handle/publica/266295
Gonorrhea (Neisseria gonorrhoeae)| CDCGonorrhea (Neisseria gonorrhoeae)| CDC
Neisseria gonorrhoeae) case definitions; uniform criteria used to define a disease for public health surveillance. ... Gonorrhea (Neisseria gonorrhoeae infection) , 2023 Case Definition. *Gonorrhea (Neisseria gonorrhoeae) , 2014 Case Definition ... Gonorrhea (Neisseria gonorrhoeae) , 1996 Case Definition. *Gonorrhea (Neisseria gonorrhoeae) , 1990 Case Definition ...
https://ndc.services.cdc.gov/conditions/gonorrhea/
Gonorrhea (Neisseria gonorrhoeae)| CDCGonorrhea (Neisseria gonorrhoeae)| CDC
Neisseria gonorrhoeae) case definitions; uniform criteria used to define a disease for public health surveillance. ... Gonorrhea (Neisseria gonorrhoeae infection) , 2023 Case Definition. *Gonorrhea (Neisseria gonorrhoeae) , 2014 Case Definition ... Gonorrhea (Neisseria gonorrhoeae) , 1996 Case Definition. *Gonorrhea (Neisseria gonorrhoeae) , 1990 Case Definition ...
https://ndc.services.cdc.gov/?p=126656
Fluoroquinolone resistance in Neisseria gonorrhoeae.Fluoroquinolone resistance in Neisseria gonorrhoeae.
Title : High-level ciprofloxacin resistance in Neisseria gonorrhoeae: first report from Israel. Personal Author(s) : Dan, M.; ... Title : Fluoroquinolone resistance in Neisseria gonorrhoeae. Personal Author(s) : Knapp, Joan S.;Fox, Kimberley K.;Trees, David ... High-level ciprofloxacin resistance in Neisseria gonorrhoeae: first report from Israel. Cite ... However, clinically significant resistance to fluoroquinolones has emerged in Neisseria gonorrhoeae. Fluoroquinolone-resistant ...
https://stacks.cdc.gov/view/cdc/3705
In vitro susceptibility of Neisseria gonorrhoeae to spectinomycin examined by a broth dilution method.<...
Levy, J. ; Wicher, K. ; Rose, N. R. / In vitro susceptibility of Neisseria gonorrhoeae to spectinomycin examined by a broth ... In vitro susceptibility of Neisseria gonorrhoeae to spectinomycin examined by a broth dilution method. / Levy, J.; Wicher, K.; ... Levy, J., Wicher, K., & Rose, N. R. (1973). In vitro susceptibility of Neisseria gonorrhoeae to spectinomycin examined by a ... Levy, J, Wicher, K & Rose, NR 1973, In vitro susceptibility of Neisseria gonorrhoeae to spectinomycin examined by a broth ...
https://jhu.pure.elsevier.com/en/publications/in-vitro-susceptibility-of-neisseria-gonorrhoeae-to-spectinomycin-3
Isotype: MIgG3, MIgM, Positive Tested Species Reactivity: Hamster, Neisseria-gonorrhoeaeIsotype: MIgG3, MIgM, Positive Tested Species Reactivity: Hamster, Neisseria-gonorrhoeae
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https://dshb.biology.uiowa.edu/custitem16/MIgG3,MIgM/custitem34/Hamster,Neisseria-gonorrhoeae?custitem16%2FMIgG2c%2CMIgM%2Fcustitem34%2FDrosophila%2CHorse=
Notes from the Field: First Case in the United States of Neisseria gonorrhoeae Harboring Emerging Mosaic penA60 Allele,...Notes from the Field: First Case in the United States of Neisseria gonorrhoeae Harboring Emerging Mosaic penA60 Allele,...
Title : Notes from the Field: First Case in the United States of Neisseria gonorrhoeae Harboring Emerging Mosaic penA60 Allele ... Notes from the Field: First Case in the United States of Neisseria gonorrhoeae Harboring Emerging Mosaic penA60 Allele, ... Notes from the Field: First Case in the United States of Neisseria gonorrhoeae Harboring Emerging Mosaic penA60 Allele, ...
https://stacks.cdc.gov/view/cdc/99501
Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge |...Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge |...
Neisseria gonorrhoeae has developed antimicrobial resistance (AMR) to all drugs previously and currently recommended for ... Starnino S, Stefanelli P. Neisseria gonorrhoeae Italian Study Group I. Azithromycin-resistant Neisseria gonorrhoeae strains ... Various penA mutations together with mtrR, porB and ponA mutations in Neisseria gonorrhoeae isolates with reduced ... Table 2 Main characteristics of the verified Neisseria gonorrhoeae superbugs and examples of sporadic gonococcal strains with ...
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-015-1029-2
Neisseria gonorrhoeae, Miscellaneous Sites, Nucleic Acid Amplification, Varies - Mayo Clinic Laboratories Rochester
Neisseria gonorrhoeae, Miscellaneous Sites, Nucleic Acid Amplification, Varies Useful For. Detection of Neisseria gonorrhoeae ... For FDA-approved specimen types, order GCRNA / Neisseria gonorrhoeae, Nucleic Acid Amplification, Varies. ...
https://testcatalog.org/show/MGRNA
Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae. - List LabsVigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae. - List Labs
Neisseria gonorrhoeae, the cause of the sexually transmitted infection gonorrhea, elicits low levels of specific Ig that ... Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae. So, NS;Ostrowski, MA; ... In considering whether N. gonorrhoeae directly influences B cells, we observed that gonococcal infection prolonged viability of ...
https://listlabs.com/citations_products/vigorous-response-of-human-innate-functioning-igm-memory-b-cells-upon-infection-by-neisseria-gonorrhoeae/

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