A genus of gram-negative, aerobic, coccoid bacteria whose organisms are part of the normal flora of the oropharynx, nasopharynx, and genitourinary tract. Some species are primary pathogens for humans.
A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.
A species of gram-negative, aerobic BACTERIA. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the NASOPHARYNX. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis (MENINGITIS, MENINGOCOCCAL). It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype.
A species of gram-negative, aerobic BACTERIA commonly found in the NASOPHARYNX of infants and children, but rarely pathogenic. It is the only species to produce acid from LACTOSE.
Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.
Infections with bacteria of the species NEISSERIA MENINGITIDIS.
Strains of Neisseria meningitidis which are the most common ones causing infections or disease in infants. Serogroup B strains are isolated most frequently in sporadic cases, and are less common in outbreaks and epidemics.
A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8)
Strains of Neisseria meningitidis found mostly in Africa.
Strains of Neisseria meningitidis responsible for most sporadic cases in teenagers and almost all outbreaks of disease in this age group. These strains are less common in infants.
Strains of Neisseria meningitidis responsible for most outbreaks of meningococcal disease in Western Europe and the United States in the first half of the 20th century. They continue to be a major cause of disease in Asia and Africa, and especially localized epidemics in Sub-Sahara Africa.
Strains of Neisseria meningitidis which, in the United States, causes disease in mostly adults and the elderly. Serogroup Y strains are associated with PNEUMONIA.
Infections with bacteria of the family NEISSERIACEAE.
A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.
A species of gram-negative, aerobic bacteria found in the human NASOPHARYNX.
A species of gram-negative, aerobic BACTERIA, found in the human NASOPHARYNX and in the normal flora of the respiratory tissues in DOLPHINS. It is occasionally pathogenic for humans and pathogenic for MICE. (Bergey's Manual of Systemic Bacteriology, 1st edition, p295)
Proteins isolated from the outer membrane of Gram-negative bacteria.
A family of gram-negative, parasitic bacteria including several important pathogens of man.
An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
Vaccines or candidate vaccines used to prevent infection with NEISSERIA MENINGITIDIS.
Porins are protein molecules that were originally found in the outer membrane of GRAM-NEGATIVE BACTERIA and that form multi-meric channels for the passive DIFFUSION of WATER; IONS; or other small molecules. Porins are present in bacterial CELL WALLS, as well as in plant, fungal, mammalian and other vertebrate CELL MEMBRANES and MITOCHONDRIAL MEMBRANES.
Proteins found in any species of bacterium.
A species of gram-negative, aerobic BACTERIA found in the human NASOPHARYNX; SALIVA; and SPUTUM.
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
The natural bactericidal property of BLOOD due to normally occurring antibacterial substances such as beta lysin, leukin, etc. This activity needs to be distinguished from the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy, which is measured by a SERUM BACTERICIDAL TEST.
A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
Substances elaborated by bacteria that have antigenic activity.
Proteins that are structural components of bacterial fimbriae (FIMBRIAE, BACTERIAL) or sex pili (PILI, SEX).
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A tube that transports URINE from the URINARY BLADDER to the outside of the body in both the sexes. It also has a reproductive function in the male by providing a passage for SPERM.
Inflammation involving the URETHRA. Similar to CYSTITIS, clinical symptoms range from vague discomfort to painful urination (DYSURIA), urethral discharge, or both.
Thin, hairlike appendages, 1 to 20 microns in length and often occurring in large numbers, present on the cells of gram-negative bacteria, particularly Enterobacteriaceae and Neisseria. Unlike flagella, they do not possess motility, but being protein (pilin) in nature, they possess antigenic and hemagglutinating properties. They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). Bacterial fimbriae refer to common pili, to be distinguished from the preferred use of "pili", which is confined to sex pili (PILI, SEX).
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Nonsusceptibility of an organism to the action of penicillins.
Techniques used in studying bacteria.
The functional hereditary units of BACTERIA.
Type species of CHLAMYDIA causing a variety of ocular and urogenital diseases.
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN A.
Substances that reduce the growth or reproduction of BACTERIA.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
A species of gram-negative, aerobic BACTERIA consisting of short chains of rods. It has been isolated from the PHARYNX of healthy individuals and patients with ENDOCARDITIS. There are several recognized subspecies.
A class of carrier proteins that bind to TRANSFERRIN. Many strains of pathogenic bacteria utilize transferrin-binding proteins to acquire their supply of iron from serum.
A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
The heritable modification of the properties of a competent bacterium by naked DNA from another source. The uptake of naked DNA is a naturally occuring phenomenon in some bacteria. It is often used as a GENE TRANSFER TECHNIQUE.
Infections with bacteria of the genus CHLAMYDIA.
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
Filamentous or elongated proteinaceous structures which extend from the cell surface in gram-negative bacteria that contain certain types of conjugative plasmid. These pili are the organs associated with genetic transfer and have essential roles in conjugation. Normally, only one or a few pili occur on a given donor cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed, p675) This preferred use of "pili" refers to the sexual appendage, to be distinguished from bacterial fimbriae (FIMBRIAE, BACTERIAL), also known as common pili, which are usually concerned with adhesion.
An envelope of loose gel surrounding a bacterial cell which is associated with the virulence of pathogenic bacteria. Some capsules have a well-defined border, whereas others form a slime layer that trails off into the medium. Most capsules consist of relatively simple polysaccharides but there are some bacteria whose capsules are made of polypeptides.
Polysaccharides found in bacteria and in capsules thereof.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
A genus of gram-negative, aerobic bacteria occurring as rods (subgenus Moraxella) or cocci (subgenus Branhamella). Its organisms are parasitic on the mucous membranes of humans and other warm-blooded animals.
The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.
Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.
Bacteriocins elaborated by mutant strains of Pseudomonas aeruginosa. They are protein or protein-lipopolysaccharide complexes lethal to other strains of the same or related species.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).
Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Change in the surface ANTIGEN of a microorganism. There are two different types. One is a phenomenon, especially associated with INFLUENZA VIRUSES, where they undergo spontaneous variation both as slow antigenic drift and sudden emergence of new strains (antigenic shift). The second type is when certain PARASITES, especially trypanosomes, PLASMODIUM, and BORRELIA, survive the immune response of the host by changing the surface coat (antigen switching). (From Herbert et al., The Dictionary of Immunology, 4th ed)
One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
A broad-spectrum antimicrobial carboxyfluoroquinoline.
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN B.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Proteins that specifically bind to IRON.
A nucleoside monophosphate sugar which donates N-acetylneuraminic acid to the terminal sugar of a ganglioside or glycoprotein.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Procedures for identification and measurement of IMMUNOGLOBULINS in the blood that initiate lysis of bacteria.
Bacterial diseases transmitted or propagated by sexual conduct.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The top portion of the pharynx situated posterior to the nose and superior to the SOFT PALATE. The nasopharynx is the posterior extension of the nasal cavities and has a respiratory function.
Bacterial infections of the leptomeninges and subarachnoid space, frequently involving the cerebral cortex, cranial nerves, cerebral blood vessels, spinal cord, and nerve roots.
Acute conjunctival inflammation in the newborn, usually caused by maternal gonococcal infection. The causative agent is NEISSERIA GONORRHOEAE. The baby's eyes are contaminated during passage through the birth canal.
Pathological processes involving the PHARYNX.
Laboratory techniques that involve the in-vitro synthesis of many copies of DNA or RNA from one original template.
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
A spectrum of inflammation involving the female upper genital tract and the supporting tissues. It is usually caused by an ascending infection of organisms from the endocervix. Infection may be confined to the uterus (ENDOMETRITIS), the FALLOPIAN TUBES; (SALPINGITIS); the ovaries (OOPHORITIS), the supporting ligaments (PARAMETRITIS), or may involve several of the above uterine appendages. Such inflammation can lead to functional impairment and infertility.
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Inflammation of the UTERINE CERVIX.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
A species of TRICHOMONAS that produces a refractory vaginal discharge in females, as well as bladder and urethral infections in males.
A genus of gram-negative, aerobic, rod-shaped bacteria whose organisms are part of the normal flora of the mucous membranes of the upper respiratory tract. Some species are pathogenic for man.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
Semisynthetic broad-spectrum cephalosporin.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.
Genotypic differences observed among individuals in a population.
A compound originally developed as an anticoagulant, but possessing anticomplement action and lowering the bactericidal action of blood. It is used in vitro to inhibit blood coagulation and as a diagnostic reagent to encourage the growth of pathogens in the blood. It is also used to stabilize colloidal solutions such as milk and gelatin. (From Merck Index, 11th ed)
A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.
Sites on an antigen that interact with specific antibodies.
The genetic complement of a BACTERIA as represented in its DNA.
Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.
An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)
Infections in birds and mammals produced by various species of Trichomonas.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Enzymes that catalyze the transfer of glycosyl groups to an acceptor. Most often another carbohydrate molecule acts as an acceptor, but inorganic phosphate can also act as an acceptor, such as in the case of PHOSPHORYLASES. Some of the enzymes in this group also catalyze hydrolysis, which can be regarded as transfer of a glycosyl group from the donor to water. Subclasses include the HEXOSYLTRANSFERASES; PENTOSYLTRANSFERASES; SIALYLTRANSFERASES; and those transferring other glycosyl groups. EC 2.4.
Diseases due to or propagated by sexual contact.
A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.
Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.
The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
A clear or white discharge from the VAGINA, consisting mainly of MUCUS.
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties.
Inflammation of the uterine salpinx, the trumpet-shaped FALLOPIAN TUBES, usually caused by ascending infections of organisms from the lower reproductive tract. Salpingitis can lead to tubal scarring, hydrosalpinx, tubal occlusion, INFERTILITY, and ectopic pregnancy (PREGNANCY, ECTOPIC)
Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.
A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.
Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
A group of enzymes with the general formula CMP-N-acetylneuraminate:acceptor N-acetylneuraminyl transferase. They catalyze the transfer of N-acetylneuraminic acid from CMP-N-acetylneuraminic acid to an acceptor, which is usually the terminal sugar residue of an oligosaccharide, a glycoprotein, or a glycolipid. EC 2.4.99.-.
A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.
Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
A species of HAEMOPHILUS that appears to be the pathogen or causative agent of the sexually transmitted disease, CHANCROID.
Pathological processes of the male URINARY TRACT and the reproductive system (GENITALIA, MALE).
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Antibodies produced by a single clone of cells.
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
All the organs involved in reproduction and the formation and release of URINE. It includes the kidneys, ureters, BLADDER; URETHRA, and the organs of reproduction - ovaries, UTERUS; FALLOPIAN TUBES; VAGINA; and CLITORIS in women and the testes; SEMINAL VESICLES; PROSTATE; seminal ducts; and PENIS in men.
Pathological processes involving the URETHRA.
A species of gram-negative bacteria originally isolated from urethral specimens of patients with non-gonoccocal URETHRITIS. In primates it exists in parasitic association with ciliated EPITHELIAL CELLS in the genital and respiratory tracts.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.
Inflammation of the vagina, marked by a purulent discharge. This disease is caused by the protozoan TRICHOMONAS VAGINALIS.
Direct nucleotide sequencing of gene fragments from multiple housekeeping genes for the purpose of phylogenetic analysis, organism identification, and typing of species, strain, serovar, or other distinguishable phylogenetic level.
Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.
A methylsulfonyl analog of CHLORAMPHENICOL. It is an antibiotic and immunosuppressive agent.
Infections of the nervous system caused by bacteria of the genus HAEMOPHILUS, and marked by prominent inflammation of the MENINGES. HAEMOPHILUS INFLUENZAE TYPE B is the most common causative organism. The condition primarily affects children under 6 years of age but may occur in adults.

In vitro activities of ketolides HMR 3647 [correction of HRM 3647] and HMR 3004 [correction of HRM 3004], levofloxacin, and other quinolones and macrolides against Neisseria spp. and Moraxella catarrhalis. (1/381)

In vitro activities of the ketolides HMR 3647 [corrected] and HMR 3004 [corrected] against pathogenic Neisseria gonorrhoeae and N. meningitidis, saprophytic Neisseria isolates, and Moraxella catarrhalis were determined. The comparison of ketolide activities with those of the other macrolides shows a much better activity in the majority of species, with macrolide MICs at which 90% of the isolates are inhibited between 8- and 10-fold higher.  (+info)

Pathogenic neisseriae: complexity of pathogen-host cell interplay. (2/381)

Recent studies have provided insight into the function of important neisserial adhesins (pili and Opa) and their interaction with cellular receptors, including members of heparan sulfate proteoglycan, CD66, and integrin receptor families. These interactions not only allow colonization of the human mucosa but also stimulate cellular signaling cascades involving phosphatidylcholine-dependent phospholipase C, acidic sphingomyelinase and protein kinase C in epithelial cells, and Src-related kinases, Rac1, p21-activated kinase, and Jun N-terminal kinase in phagocytic cells. Activation of these pathways is essential for cellular entry and intracellular accommodation of the pathogens but also leads to early induction of cytokine release, thus priming the immune response. Detailed knowledge of the cellular signaling cascades that are activated by infection will aid us in applying both current and novel interfering drugs (in addition to classical antibiotic therapy) as therapy and prophylaxis for persistent or otherwise difficult-to-treat bacterial infections, including periodontal infections.  (+info)

Structural and evolutionary inference from molecular variation in Neisseria porins. (3/381)

The porin proteins of the pathogenic Neisseria species, Neisseria gonorrhoeae and Neisseria meningitidis, are important as serotyping antigens, putative vaccine components, and for their proposed role in the intracellular colonization of humans. A three-dimensional structural homology model for Neisseria porins was generated from Escherichia coli porin structures and N. meningitidis PorA and PorB sequences. The Neisseria sequences were readily assembled into the 16-strand beta-barrel fold characteristic of porins, despite relatively low sequence identity with the Escherichia proteins. The model provided information on the spatial relationships of variable regions of peptide sequences in the PorA and PorB trimers and insights relevant to the use of these proteins in vaccines. The nucleotide sequences of the porin genes from a number of other Neisseria species were obtained by PCR direct sequencing and from GenBank. Alignment and analysis of all available Neisseria porin sequences by use of the structurally conserved regions derived from the PorA and PorB structural models resulted in the recovery of an improved phylogenetic signal. Phylogenetic analyses were consistent with an important role for horizontal genetic exchange in the emergence of different porin classes and confirmed the close evolutionary relationships of the porins from N. meningitidis, N. gonorrhoeae, Neisseria lactamica, and Neisseria polysaccharea. Only members of this group contained three conserved lysine residues which form a potential GTP binding site implicated in pathogenesis. The model placed these residues on the inside of the pore, in close proximity, consistent with their role in regulating pore function when inserted into host cells.  (+info)

Erythromycin-resistant Neisseria gonorrhoeae and oral commensal Neisseria spp. carry known rRNA methylase genes. (4/381)

Two Neisseria gonorrhoeae isolates from Seattle and two isolates from Uruguay were resistant to erythromycin (MIC, 4 to 16 microg/ml) and had reduced susceptibility to azithromycin (MIC, 1 to 4 microg/ml) due to the presence of the self-mobile rRNA methylase gene(s) ermF or ermB and ermF. The two Seattle isolates and one isolate from Uruguay were multiresistant, carrying either the 25.2-MDa tetM-containing plasmid (Seattle) or a beta-lactamase plasmid (Uruguay). Sixteen commensal Neisseria isolates (10 Neisseria perflava-N. sicca, 2 N. flava, and 4 N. mucosa) for which erythromycin MICs were 4 to 16 microg/ml were shown to carry one or more known rRNA methylase genes, including ermB, ermC, and/or ermF. Many of these isolates also were multiresistant and carried the tetM gene. This is the first time that a complete transposon or a complete conjugative transposon carrying an antibiotic resistance gene has been described for the genus Neisseria.  (+info)

Networks and groups within the genus Neisseria: analysis of argF, recA, rho, and 16S rRNA sequences from human Neisseria species. (5/381)

To understand the pattern of nucleotide sequence variation among bacteria that frequently exchange chromosomal genes, we analyzed sequences of the recA, argF, and rho genes, as well as part of the small-subunit (16S) rRNA gene, from about 50 isolates of human commensal Neisseria species and the pathogenic N. meningitidis and N. gonorrhoeae. Almost all isolates of these species could be assigned to five phylogenetic groups that are found for all genes examined and generally are supported by high bootstrap values. In contrast, the phylogenetic relationships among groups varied according to the gene analyzed with notable incongruences involving N. cinerea and N. lactamica. Further analysis using split decomposition showed that for each gene, including 16S rRNA, the patterns of sequence divergence within N. meningitidis and closely related species were inconsistent with a bifurcating treelike phylogeny and better represented by an interconnected network. These data indicate that the human commensal Neisseria species can be separated into discrete groups of related species but that the relationships both within and among these groups, including those reconstructed using 16S rRNA, have been distorted by interspecies recombination events.  (+info)

Molecular cloning, functional expression and purification of a glucan branching enzyme from Neisseria denitrificans(1). (6/381)

The nucleotide sequence containing the complete structural information for a glucan branching enzyme was isolated from a Neisseria denitrificans genomic library. The gene was expressed in Escherichia coli and the active recombinant protein was purified. The deduced protein of 762 amino acids with a calculated molecular weight of 86313 Da shows similarity to the primary protein sequences of other known glucan branching enzymes. Amino acid sequencing of the isolated protein by Edman degradation confirmed the deduced start codon of the structural gene of the glucan branching enzyme. The purified glucan branching enzyme has a stimulating effect on the Neisseria amylosucrase activity.  (+info)

Purification and characterization of an esterase involved in cellulose acetate degradation by Neisseria sicca SB. (7/381)

An esterase catalyzing the hydrolysis of acetyl ester moieties in cellulose acetate was purified 1,110-fold to electrophoretic homogeneity from the culture supernatant of Neisseria sicca SB, which can assimilate cellulose acetate as the sole carbon and energy source. The purified enzyme was a monomeric protein with a molecular mass of 40 kDa and the isoelectric point was 5.3. The pH and temperature optima of the enzyme were 8.0-8.5 and 45 degrees C. The enzyme catalyzed the hydrolysis of acetyl saccharides, p-nitrophenyl esters of short-chain fatty acids, and was slightly active toward aliphatic and aromatic esters. The K(m) and Vmax for cellulose acetate (degree of substitution, 0.88) and p-nitrophenyl acetate were 0.0162% (716 microM as acetyl content in the polymer) and 36.0 microM, and 66.8 and 39.1 mumol/min/mg, respectively. The enzyme was strongly inhibited by phenylmethylsulfonyl fluoride and diisopropyl fluorophosphate, which indicated that the enzyme was a serine esterase.  (+info)

Rapid micro-carbohydrate test for confirmation of Neisseria gonorrhoeae. (8/381)

A rapid carbohydrate utilization procedure for the confirmation of Neisseria gonorrhoeae and identification of other Neisseria species has been developed. This method utilizes both preformed enzymes, introduced in a heavy inoculum, and enzymes formed by the microorganisms as a result of growth in a small volume of super-enriched medium. Expected carbohydrate reactions were produced by 383 clinical isolates of neisseriae and were clearly visible within 4 h of incubation. The combined use of disposable glass tubes (6 by 50 mm) and microamounts of media (0.05 ml) make this method not only rapid, but also low in cost.  (+info)

Methods for identifying Neisseria spp. include conventional and modified carbohydrate degradation procedures, chromogenic enzyme substrate tests, and immunologic coagglutination tests for Neisseria gonorrhoeae. In this study, we evaluated the abilities of the RIM-N carbohydrate degradation system (American MicroScan, Campbell, Calif.), the Gonochek II enzymatic identification system (Du Pont Co., Wilmington, Del.), and the Phadebact Gonococcus coagglutination test (Pharmacia Diagnostics, Piscataway, N.J.) to identify pathogenic Neisseria spp. and Branhamella catarrhalis. Both stock strains and clinical isolates, including 176 N. gonorrhoeae, 173 Neisseria meningitidis, 48 Neisseria lactamica, and 12 B. catarrhalis strains, were tested. The RIM-N identified 98% of the gonococci, 99% of the meningococci, 94% of the N. lactamica strains, and 100% of the B. catarrhalis strains within 1 h. The Gonochek II system identified 99% of the gonococci, 97% of the meningococci, 100% of the N. lactamica ...
Third, some gonococci are able to engage in conjugation, which is essentially bacteria sex! During conjugation, one bacterium uses an appendage called a sex pilus to attach to another bacterium and deliver a circular piece of DNA from the donor to the recipient. The recipient is now in possession of any traits its new DNA encodes.. You know how we humans are officially Homo sapiens? The scientific name for gonococci is Neisseria gonorrhoeae. And, just as we had genetic cousins in the form of Homo neanderthalensis (aka the Neanderthals), so too do Neisseria gonorrhoeae have cousins in the Neisseria genus. Most human-associated Neisseria species dont cause disease, and live peacefully in our upper respiratory tracts. These species include Neisseria flavescens, Neisseria flava, Neisseria perflava, Neisseria mucosa, Neisseria sicca, Neisseria polysaccharea, and more.. When gonococci meet their cousins at a family reunion, they dont swap recipes for potato salad - they swap genetic material. ...
Neisseria perflava ATCC ® 14799D-5™ Designation: Genomic DNA from Neisseria perflava strain 28 TypeStrain=False Application:
Curated}} {{Biorealm Genus}} [[Image:ng-lym1.jpg,thumb,250px,right,Neisseria gonorrhoeae. From [http://neisseria.org/ng/images/ Dr. Ian Boulton.]]] ==Classification== ===Higher order taxa:=== Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae ===Species:=== Neisseria animalis; N. bacilliformis; N. canis; N. cinerea; N. dentrificans; N. dentiae; N. elongata; N. flava; N. flavescens; [[N. gonorrhoeae]]; N. iguanae; N. lactamica; N. macacae; N. meningitidis; N. mucosa; Neisseria perflava; Neisseria pharyngis; Neisseria polysaccharea; N. sicca; N. subflava; N. weaveri; N. sp. {, , height=10 bgcolor=#FFDF95 align=center , NCBI: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=482&lvl=3&lin=f&keep=1&srchmode=1&unlock Taxonomy] Genome: -,font size=2>[http://www.ncbi.nlm.nih.gov/genomes/framik.cgi?db=Genome&gi=155 Neisseria meningitidis MC58] -[http://www.ncbi.nlm.nih.gov/genomes/framik.cgi?db=Genome&gi=156 Neisseria meningitidis Z2491 ...
Author Summary Many bacteria are able to secrete toxins targeted against neighboring cells. In order to protect themselves against their own toxin, they also express an
Horizontal gene transfer is an important source of genetic variation among Neisseria species and has contributed to the spread of resistance to penicillin and sulfonamide drugs in the pathogen Neisseria meningitidis. Sulfonamide resistance in Neisseria meningitidis is mediated by altered chromosomal folP genes. At least some folP alleles conferring resistance have been horizontally acquired from other species, presumably from commensal Neisseriae. In this work, the DNA sequence surrounding folP in commensal Neisseria species was determined and compared to corresponding regions in pathogenic Neisseriae, in order to elucidate the potential for inter-species DNA transfer within this region ...
Genus Neisseria has a specie called Neisseria gonorhea or commonly called Gonococcus. It has a gram negative, kidney or bean shaped intracellular diplococcic. This is usually killed when outside of the human body. It is transmitted through sexual intercourse, with an infected partner via infected birth canal of infected mother during delivery; indirectly transmitted via contaminated hands, fomites contaminated with purulent discharges; directly also via oral sex.. Gonorrhea originated from the two Greek words: gono meaning semen and rhein which means flow. It is an acute, inflammatory and infectious disease o the mucus membrane of the genitor-urinary tracts of men and women as well as the eyes of the newborn due to N. Gonorrhoea. Its incubation period usually is 3-5 days after the contact with an infected partner. ...
1JG9: Crystal structures of amylosucrase from Neisseria polysaccharea in complex with D-glucose and the active site mutant Glu328Gln in complex with the natural substrate sucrose.
The emergence of antibiotic-resistant gonorrhea is considered one of the most pressing problems in infectious disease - just two years ago, the Centers for Disease Control and Prevention named it an urgent threat, and indeed, gonorrhea seems to be evolving resistance to drugs at quite a rapid clip. Gonococci can acquire resistance to antibiotics in three ways.. First, a genetic mutation can endow bacteria with special antibiotic-fighting powers, making it harder for a drug like penicillin to attach to their cells and destroy them. Such a mutant is more likely to gain evolutionary traction if it finds itself in an antibiotic-drenched environment in which resistance to that drug allows it to outcompete other bacteria. Indeed, antibiotic resistance was first documented in the 1940s, just years after sulfonamides and penicillin were introduced as the first effective cures for gonorrhea. Continue reading →. ...
The Neisseria species are believed to be non-clonal bacteria with a high degree of genetic transfer within and between different species [2, 3, 14-18]. Previous reports of transformation in N. meningitidis have suggested that different regions of the genome may have different recombination rates [19, 20]. This work identified the region upstream of folP as particularly active in recombination events. The most obvious example is the insertion of a complete Correia element, upstream of folP in N. lactamica. Correia elements are small putative transposable elements, around 152 base pairs long with inverted repeats at the ends [12]. Hundreds of Correia copies are scattered around the genomes of pathogenic Neisseriae [13, 21, 22] and they have also been reported in N. lactamica [23]. We detected another copy of a Correia repeat in the N. subflava sequence, suggesting that these elements are ubiquitous in the Neisseria genus and possibly was introduced before the divergence into different ...
In the context of our interest in host-pathogen interactions, we are pursuing currently the following projects:. Neisseria. We have developed a novel mouse model to study the mechanisms of commensalism, from the standpoint of both the host and bacterium. The model involves noninvasive inoculation of the well-studied lab mouse with a new commensal Neisseria species isolated from the normal flora of healthy wild mice. The model allows studies of colonization, and the elusive process of persistence, in a variety of mucosal niches, from the relatively well-studied intestinal tract to the less well-studied respiratory tract and oral cavity. Experimentation is guided by a vast store of knowledge on the mouse and close relatives of the bacterium. Using this unique model, we will identify immune processes and mouse genes critical for susceptibility to N. tucsonensis colonization and bacterial genes critical for colonization and persistence.. Valley Fever. Coccidioidomycosis is a serious respiratory ...
Author Summary The closely related bacterial species N. meningitidis, N. gonorrhoeae and N. lactamica exclusively colonise mucosal surfaces in humans. While N. gonorrhoeae leads to gonorrhea, the other two species persist mainly in their host in the absence of disease. N. meningitidis does occasionally cause severe, life threatening illness, however. Little is known about the factors and elements that dictate the unique human interactions exhibited by each species. Moreover, the evolutionary relationships between these species are poorly characterized. Here, we describe two successive alterations in a single gene that can be linked first to all species within the genus Neisseria and then the species N. meningitidis. We also show these signature alterations have phenotypic consequences by affecting core respiratory metabolic processes. These findings have significant implications for the evolution of related bacterial species within a single host and provide a novel perspective on the episodic and
The genus Neisseria contains many species. Most of them are part of the normal flora of humans and animals; only two are human pathogens: Neisseria gonorrhoeae, which causes a sexually transmitted disease of the same name, and Neisseria meningitidis, which causes meningitis. These pathogens often behave like their related commensal cousins in that they establish asymptomatic infection at high frequency. This commensal-like trait was likely inherited by the pathogens as they evolved from commensal species. Supporting this idea is the observation that many N. gonorrhoeae and N. meningiditis genes that mediate pathogen interactions with their hosts are also in the commensals. A major goal of our lab is to determine how commensal and pathogenic Neisseria differentially regulate these host interaction genes, and how these regulatory events might affect their lifecycle in the host.. Another goal of our lab is to use our new mouse model for Neisseria colonization, persistence, and asymptomatic ...
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PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
It is important to understand the caveats to interpreting the MenDeVAR Index:. Source of data - These data combine multiple sources of information including: peptide sequence identity through whole genome sequencing; experimental assays developed as indirect measures of the breadth of vaccine protection against diverse meningococci; and assays developed to assess immunogenicity. The Meningococcal Antigen Typing System (MATS)2 assay was used for Bexsero®.. Cross-reactivity definition - An antigenic variant was considered cross-reactive if it had been tested in ≥5 isolates/subjects and was above the accepted threshold in ≥75% of those isolates. This was established through combined analysis of published experimental studies (PMID provided for each variant), not from genomic data. These assays were based on serogroup B disease isolates.. Protein expression - We have not inferred from genomic data, therefore there may be isolates that possess genes but do no express the protein in vivo.. Age of ...
Please select the required isolate ids and loci for comparison - use CTRL or SHIFT to make multiple selections in list boxes. In addition to selecting individual loci, you can choose to include all loci defined in schemes by selecting the appropriate scheme description.. Interactive analysis is limited to 750,000 data points (isolates x loci). If you select more than this then output will be restricted to static tables ...
The insulin signaling pathways play key roles in energy metabolism, growth, and cellular differentiation. The key ligands for these pathways include the hormone insulin and insulin-like growth factors I and II (IGF1 and IGF2). These ligands bind with different affinities to insulin receptor and IGF1 receptor homo- and heteroduplexes. Receptor activation leads to downstream signaling through the MAPK and PI3K signaling pathways, ultimately activating target gene expression. Signaling through the insulin receptor either promotes mitogenesis or glucose and fatty acid storage. This pathway also inhibits lipid and carbohydrate degradation. Signaling through IGF1R promotes cell growth and inhibits apoptosis. Dysregulation of these pathways commonly occurs during carcinogenesis, possibly due to the prominent role of insulin signaling in mitogenesis. Insulin resistance is a common symptom of diabetes and obesity, resulting from dysregulated energy homeostasis ...
The insulin signaling pathways play key roles in energy metabolism, growth, and cellular differentiation. The key ligands for these pathways include the hormone insulin and insulin-like growth factors I and II (IGF1 and IGF2). These ligands bind with different affinities to insulin receptor and IGF1 receptor homo- and heteroduplexes. Receptor activation leads to downstream signaling through the MAPK and PI3K signaling pathways, ultimately activating target gene expression. Signaling through the insulin receptor either promotes mitogenesis or glucose and fatty acid storage. This pathway also inhibits lipid and carbohydrate degradation. Signaling through IGF1R promotes cell growth and inhibits apoptosis. Dysregulation of these pathways commonly occurs during carcinogenesis, possibly due to the prominent role of insulin signaling in mitogenesis. Insulin resistance is a common symptom of diabetes and obesity, resulting from dysregulated energy homeostasis ...
Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, BIOLOGY, NEISSERIA-MENINGITIDIS, POPULATION-STRUCTURE, GENETIC EXCHANGE, GENUS NEISSERIA, STREPTOCOCCUS, RECOMBINATION, PROKARYOTES, DEFINITION, PHYLOGENY, SEQUENCES. ...
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TY - JOUR. T1 - Nasal inoculation of the commensal neisseria lactamica inhibits carriage of neisseria meningitidis by young adults. T2 - A controlled human infection study. AU - Deasy, Alice M.. AU - Guccione, Ed. AU - Dale, Adam P.. AU - Andrews, Nicholas. AU - Evans, Cariad M.. AU - Bennett, Julia S.. AU - Bratcher, Holly B.. AU - Maiden, Martin C.J.. AU - Gorringe, Andrew. AU - Read, Robert C.. N1 - Funding Information: Financial support. This work was supported by Life for a Cure, a charity established by Michelle and John Bresnahan in memory of their son Ryan; and Meningitis UK (now Meningitis Now). Potential conflicts of interest. All authors: No reported conflicts. Funding Information: Acknowledgments. Infrastructure and Service support was provided by the National Institute of Health Research Clinical Research Network, UK. We are grateful to the university volunteers who took part in this project and would also like to thank Abida Nazir and the staff in the Clinical Research Unit at the ...
The availability of new polysaccharide-protein conjugate vaccines against Neisseria meningitidis serogroup C prompted European National Health authorities to carefully monitor isolate characteristics. In Italy, during 1999-2001, the average incidence was 0.4 cases per 100,000 inhabitants. Serogroup B was predominant and accounted for 75% of the isolates, followed by serogroup C with 24%. Serogroup C was isolated almost twice as frequently in cases of septicemia than in cases of meningitis, and the most common phenotypes were C: 2a:P1.5 and C:2b:P1.5. Among serogroup B meningococci, the trend of predominant phenotypes has changed from year to year, with a recent increase in the frequency of B:15:P1.4. Only a few meningococci had decreased susceptibility to penicillin, and, in the penA gene, all of these strains had exogenous DNA blocks deriving from the DNA of commensal Neisseria flavescens, Neisseria cinerea, and Neisseria perflava/sicca. Fluorescent amplified fragment-length polymorphism ...
The genome of Neisseria meningitidis serogroup B strain MC58 contains three genes - nmb0278, nmb0294 and nmb0407 - encoding putative homologues of DsbA, a periplasmic thiol disulphide oxidoreductase protein-folding catalyst of the Dsb protein family. DsbA assists the folding of periplasmic and membrane proteins in diverse organisms. While all three cloned genes complemented the DTT sensitivity of dsbA-null Escherichia coli, they showed different activities in folding specific target proteins in this background. NMB0278 protein was the most active in complementing defects in motility and alkaline phosphatase activity, while NMB0294 was the most active in folding periplasmic MalF. NMB0407 showed the weakest activity in all assays. It is extremely unusual for organisms to contain more than one chromosomal dsbA. Among the members of the genus Neisseria, only the meningococcus carries all three of these genes. Strains of Neisseria gonorrhoeae, Neisseria lactamica, Neisseria cinerea and Neisseria
Fumarase is one of the key enzymes in the TCA cycle and has been implicated in virulence and survival of some microorganisms under suboptimal environmental conditions. In this study, the fumC genes that encode fumarase C (FUMCs) from Neisseria meningitidis, N. gonorrhoeae and N. subflava were identified by homology-based analysis, cloned by polymerase chain reactions and fully sequenced. The inferred primary sequence of neisserial FUMCs showed a high degree of conservation with 97.8-98.7% amino acid identity. However, phylogenetic analysis revealed that these neisserial FUMCs are divergent from class II fumarases found in other microorganisms, rat and human. The putative fumC genes were subcloned into the expression vector, pGEX-6P-1 and efficiently expressed in Esherichia coli BL21. The purified recombinant fusion proteins obtained by affinity chromatography demonstrated high catalytic activities (120-180 U/mg), thus authenticating the identities and functionalities of the cloned genes. Whether ...
A DNA vaccine strategy for effective antibody induction to pathogen-derived antigens -- Antigen identification starting from the genome: A Reverse vaccinology Approach applied to MenB -- Analysis of the immune response to Neisseria meningitidis using a proteomics approach -- Analysis of parameters associated with prevention of cellular apoptosis by pathogenic Neisseriae and purified porins -- The use of the pan-Neisseria microarray and experimental design for transcriptomics studies of Neisseria -- Transcriptome analyses in the interaction of Neisseria meningitidis with mammalian host cells -- Visualising PAMP-PRR interactions using nanoscale imaging -- Hydrogen-deuterium exchange coupled to mass spectrometry to investigate ligand-receptor interactions -- Human dendritic cell culture and bacterial infection -- Techniques to measure pilus retraction forces -- A laminar-flow chamber assay for measuring bacterial adhesion under shear stress -- Methods for studying Neisseria meningitidis biofilms ...
A DNA vaccine strategy for effective antibody induction to pathogen-derived antigens -- Antigen identification starting from the genome: A Reverse vaccinology Approach applied to MenB -- Analysis of the immune response to Neisseria meningitidis using a proteomics approach -- Analysis of parameters associated with prevention of cellular apoptosis by pathogenic Neisseriae and purified porins -- The use of the pan-Neisseria microarray and experimental design for transcriptomics studies of Neisseria -- Transcriptome analyses in the interaction of Neisseria meningitidis with mammalian host cells -- Visualising PAMP-PRR interactions using nanoscale imaging -- Hydrogen-deuterium exchange coupled to mass spectrometry to investigate ligand-receptor interactions -- Human dendritic cell culture and bacterial infection -- Techniques to measure pilus retraction forces -- A laminar-flow chamber assay for measuring bacterial adhesion under shear stress -- Methods for studying Neisseria meningitidis biofilms ...
Neisseria spp. - Includes:Neisseria gonorrhoeaeNeisseria meningitidis - Neisseria gonorrhoeae - Neisseria meningitidis - Gram-negative diplococciContain lipooligosaccharides (LOS) with strong endotoxin activity - Contain lipooligosaccharides (LOS) with strong endotoxin activity - Facultatively intracellularOften visualized within epithelial cells - Often visualized within epithelial cells - Grows on Thayer-Martin agarSelective chocolate (heated-blood) agar-based medium containing the antibiotics vancomycin, colistin, nystatin and trimethoprimPrevents growth of microbes other than Neisseria - Selective chocolate (heated-blood) agar-based medium containing the antibiotics vancomycin, colistin, nystatin and trimethoprim - Prevents growth of microbes other than Neisseria - Produce IgA proteaseCleave IgA at hinge region, impairing its function at mucosal surfacesImproves mucosal adherence - Cleave IgA at hinge region, impairing its function at mucosal surfaces - Improves mucosal adherence - Increased risk
The Neisseria gonorrhoeae population structure is not clonal [1-5], its panmictic structure being the result of horizontal genetic exchange [6]. The pathogenic Neisseria spp. are naturally transformable [7] and chromosomal changes are largely mediated by homologous recombination. Natural competence for transformation and homologous recombination allow the generation of mosaic genes, such as the divergent opa genes [8, 9], antigenic variation through recombination with silent cassettes, such as in the pilE/pilS system [10, 11], and the horizontal exchange of whole genes or groups of genes in Minimal Mobile Elements (MMEs) [12]. A Minimal Mobile Element (MME) is defined as a region between two conserved genes within which different genes are found in different strains. These elements are described as minimal reflecting the fact that they do not have features suggesting mobilization by associated transposases, nor do they currently appear to have features by which remotely encoded systems would ...
Neisseria mucosa ATCC ® 49233™ Designation: AmMS 138 TypeStrain=False Application: Quality control of MicroScan ® panels
Looking for online definition of Neisseria ovis in the Medical Dictionary? Neisseria ovis explanation free. What is Neisseria ovis? Meaning of Neisseria ovis medical term. What does Neisseria ovis mean?
Looking for online definition of Neisseria in the Medical Dictionary? Neisseria explanation free. What is Neisseria? Meaning of Neisseria medical term. What does Neisseria mean?
After publication of the original article [1] it was identified that an incorrect version of the manuscript has been published. This was caused by a technical error which led to a discrepancy between the editorially-accepted version of the manuscript, and the published version.
The Neisseriaceae are a family[2] of Proteobacteria, within the Neisseriales order. While many organisms in the family are mammalian commensals or part of the normal flora, the genus Neisseria includes two important human pathogens, specifically those responsible for gonorrhea (caused by N. gonorrhoeae) and many cases of meningitis (meningococcal meningitis, caused by N. meningitidis). As a group, the Neisseriaceae are strictly aerobic and Gram-negative, occur mainly in pairs (diplococci), and typically do not have flagella. ...
Tezera, L., Molierinho, S., Virji, M., Jackson, S. K. and Davenport, V. (2008) Differential induction on innate immunity to Neisseria lactamica and N.meningitidis in nasopharyngeal epithelial cells. In: 16th International Pathogenic Neisseria Conference, Rotterdam, 7-12 September 2008. Available from: http://eprints.uwe.ac.uk/7487 ...
Tezera, L., Molierinho, S., Virji, M., Jackson, S. K. and Davenport, V. (2008) Differential induction on innate immunity to Neisseria lactamica and N.meningitidis in nasopharyngeal epithelial cells. In: 16th International Pathogenic Neisseria Conference, Rotterdam, 7-12 September 2008. Available from: http://eprints.uwe.ac.uk/7487 ...
Bacillus amyloliquefaciens strain FZB42 is a free-living bacterium that competitively colonizes plant roots and stimulates plant growth by many different modes of action. The molecular basis of singular beneficial effects that this Plant Growth-Promoting Rhizobacteria (PGPR) exert on their hosts have been studied. To decipher the molecular cross-talk of B. amyloliquefaciens and its host plants as a whole system, an extensive proteomic approach was performed. Reference maps of the extracellular and cytosolic protein fractions were established. The highest number of secreted proteins was observed during stationary growth phase. Identified extracellular proteins belong to different functional classes, with the most prominent classes involved in carbohydrate degradation and transportation of molecules across the cell wall. Cytosolic extracts obtained from cultures grown in 1C and minimal media subjected to the 2 Dimensional Electrophoresis (2 DE), revealed 461 and 245 different protein entries, ...
The genome of the thermophilic fungus Scytalidium thermophilum (strain CBS 625.91) harbours a wide range of genes involved in carbohydrate degradation, including three genes, abf62A, abf62B and abf62C, predicted to encode glycoside hydrolase family 62 (GH62) enzymes. Transcriptome analysis showed that only abf62A and abf62C are actively expressed during growth on diverse substrates including straws from barley, alfalfa, triticale and canola. The abf62A and abf62C genes were expressed in Escherichia coli and the resulting recombinant proteins were characterized. Calcium-free crystal structures of Abf62C in apo and xylotriose bound forms were determined to 1.23 and 1.48 Å resolution respectively. Site-directed mutagenesis confirmed Asp55, Asp171 and Glu230 as catalytic triad residues, and revealed the critical role of non-catalytic residues Asp194, Trp229 and Tyr338 in positioning the scissile α-L-arabinofuranoside bond at the catalytic site. Further, the +2R substrate-binding site residues ...
The wood of the gender Eucalyptus occupies a prominence place among other cellulose sources due to its chemical composition, its low cost, abundance and availability. Among the chemical pulping processes, kraft process is the most extensively one used for the production of cellulosic pulps starting from eucalyptus wood. The anthraquinone (AQ) usage in the pulping has as main purposes to increase the delignification rate as well as to protect the pulp from the carbohydrate degradation. The present work has aimed to use the anthraquinone as an addictive in the cooking seeking to reduce the load of applied sulphidity without harming the quality of the pulp. The kraft and kraft/AQ cooking were accomplished in rotative laboratorial digester being varied the active alkali initially (10, 13, 16 and 19%) and, later, the sulphidity (5, 10, 15, 20 and 25%), maintaining the other conditions constant aiming to obtain pulp with kappa number close to nine. Starting from the variation of the active alkali and ...
General Information: Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria ...
General Information: Isolated from a patient with meningococcal septicemia. Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, ...
|strong|Rabbit anti |em|Neisseria meningitidis|/em| antibody|/strong|reacts with |i|Neisseria meningitidis |/i| serogroups A, B and C recognizing multiple antigens. Other serogroups have not been test…
Neisseria meningitidis, a causative agent of bacterial meningitis, has a relatively small repertoire of transcription factors, including NMB0573 (annotated AsnC), a member of the Lrp-AsnC family of regulators that are widely expressed in both Bacteria and Archaea. In the present study we show that NMB0573 binds to l-leucine and l-methionine and have solved the structure of the protein with and without bound amino acids. This has shown, for the first time that amino acid binding does not induce significant conformational changes in the structure of an AsnC/Lrp regulator although it does appear to stabilize the octameric assembly of the protein. Transcriptional profiling of wild-type and NMB0573 knock-out strains of N. meningitidis has shown that NMB0573 is associated with an adaptive response to nutrient poor conditions reflected in a reduction in major surface protein expression. On the basis of its structure and the transcriptional response, we propose that NMB0573 is a global regulator in Neisseria
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TY - JOUR. T1 - Interrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera. AU - Mendum, Tom A.. AU - McFadden, Johnjoe. A2 - Newcombe, Jane. A2 - Mannan, Ahmad A. A2 - Kierzek, Andrzej M. PY - 2011/12/30. Y1 - 2011/12/30. N2 - BackgroundNeisseria meningitidis is an important human commensal and pathogen that causes several thousand deaths each year, mostly in young children. How the pathogen replicates and causes disease in the host is largely unknown, particularly the role of metabolism in colonization and disease. Completed genome sequences are available for several strains but our understanding of how these data relate to phenotype remains limited.ResultsTo investigate the metabolism of N. meningitidis we generated and then selected a representative Tn5 library on rich medium, a minimal defined medium and in human serum to identify genes essential for growth under these conditions. To relate these data to a ...
Bacterial infection of human vasculature can lead to unregulated systemic activation of coagulation and innate immunity and rapidly becomes life threatening. Neisseria meningitidis is a vascular pathogen that causes fatal septic shock and meningitis. Post-mortem histological analysis of tissues from individuals infected with N. meningitidis show large bacterial aggregates in close association with the vascular wall of small vessels. The ability of this bacterium to colonize blood vessel endothelium is likely to impact its capacity to both multiply in the blood stream and reach the brain. This process is referred to as vascular colonization. Recent work from our group exploring the early steps in N. meningitidis vascular colonization will be reported, from attachment to proliferation and dissemination, focusing on the bacterial-host interaction.. Selected publications. ...
Acronym using Neisseria. Acronym including the word Neisseria Acronyms with NEISSERIAFurther acronym search. Find the acronyms that include a word!
Mendum , T A , Newcombe , J , Mannan , A A , Kierzek , A M & McFadden , J 2011 , Interrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera , Genome Biology , vol. 12 , R127 . https://doi.org/10.1186/gb-2011-12-12- ...
Neisseria meningitidis, IgG, Vaccine Response, MAID (Quest). Get know how much does lab test cost. Direct access testing with or without insurance.
Domain combinations containing the TrpR-like superfamily in Neisseria meningitidis Z2491. Domain architectures illustrate each occurrence of the TrpR-like superfamily.
Antigenic potential of a highly conserved Neisseria meningitidis lipopolysaccharide inner core structure defined by chemical synthesis
Neisseria gonorrheae bacteria are the causative agent of the second most common sexually transmitted infection in the world. The bacteria move on a surface by means of twitching motility. Their movement is mediated by multiple long and flexible filaments, called type IV pili, that extend from the cell body, attach to the surface, and retract, thus generating a pulling force. Moving cells also use pili to aggregate and form microcolonies. However, the mechanism by which the pili surrounding the cell body work together to propel bacteria remains unclear. Understanding this process will help describe the motility of N. gonorrheae bacteria, and thus the dissemination of the disease which they cause. In this article we track individual twitching cells and observe that their trajectories consist of alternating moving and pausing intervals, while the cell body is preferably oriented with its wide side toward the direction of motion. Based on these data, we propose a model for the collective pili ...
Neisseria meningitis is a human commensal bacterium that occasionally causes life-threatening disease. As with a number of other bacterial pathogens, meningococcal populations comprise distinct lineages, which persist over many decades and during global spread in the face of high rates of
Eine einfache Messung der ATP Assay und lebenden/Toten Färbung Methode dienten zu quantifizieren und zu visualisieren, Neisseria...
What do UK sexual health clinicians think about saliva as a transmissible vector for Neisseria g onorrhoea e in men who have sex with men? ...
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As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
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It is also called knock knees. It is a condition in which the knee angle is in and they touch each other when the legs are straightened ...
Neisseria sp., Mannheimia haemolytica, Pasteurella ureae, Proteus mirabilis, P. penneri, Pseudomonas sp., Salmonella sp., ...
Thjötta (1938). "Neisseria hemolysans. A Hemolytic Species of Neisseria trevisan". Acta Path. Et Microb. Scandinavica. BERGER, ... It was reclassified as a new genus in 1960 when strains were found to be distinct enough from Neisseria to require a new genus ... A Gemella species was first described as Neisseria hemolysans in 1938. ...
Neisseria sp. and Lactobacillus sp. etc.26, 27 Furthermore, Candida albicans can grow well in highly acidic environments,28 and ... Haemophilus and Neisseria) are present. Fungal genera include Candida, Aspergillus, and Penicillium. The lachrymal glands ... Neisseria meningitidis, and Staphylococcus aureus.[citation needed] Fungal genera that compose the pulmonary mycobiome include ...
... s are effective only against aerobic Gram-negative bacteria (e.g., Neisseria, Pseudomonas). Siderophore-conjugated ...
Neisseria spp.) groups of four or eight known respectively as tetrads and sarcina (e.g. Micrococcus spp.) bead-like chains (e.g ...
Neisseria spp.) and selected Gram-positive bacteria. Its ligands also include several viral proteins, polysaccharide, and a ...
Neisseria meningitidis; Streptococcus Pneumoniae; and Streptococcus pyogenes. The Gram-negative bacterium B.burgdorferi has ...
Neisseria species • Pseudomonas aeruginosa • Pseudomonas pyocyanea • Salmonella species • Selenomonas sputigena • Shigella ...
Neisseria meningitidis. Meningococcal meningitis. Meningococcal vaccine. Serotype C: Neisvac C and Meningitec. Serotypes A/C/W- ...
Neisseria species. *Streptococcus pneumoniae. Primary or secondary[edit]. Distinction between primary versus secondary ...
talk , contribs)‎ (→‎Requesting an assessment or re-assessment: neisseria gonorrhoeae). 8 December 2017. *(diff , hist) . . m ...
Neisseria gonorrhoeae[editar , editar a fonte]. Neisseria gonorrhoeae é a bacteria transmitida por vía sexual que produce a ... Deguchi T, Nakane K, Yasuda M, Maeda S (setembro de 2010). "Emergence and spread of drug resistant Neisseria gonorrhoeae". J. ...
Hollis DG, Wiggins GL, Weaver RE (January 1969). "Neisseria lactamicus sp. n., a lactose-fermenting species resembling ... Neisseria meningitidis". Appl Microbiol. 17 (1): 71-7. PMC 377615. PMID 4975454. "University of Wisconsin - Madison, Veterinary ...
Unlike Neisseria meningitidis, which is a morphological relative of M. catarrhalis, it hardly ever causes bacteremia or ... LPSN lpsn.dsmz.de Ala'Aldeen, D. A. A. (2007). "Neisseria and moraxella". In Greenwood, David; Slack, Richard; Peitherer, John ...
... a Chlamydia trachomatis or Neisseria gonorrhoeae infection may be the cause.[9][43] These infections are typically classified ...
Neisseria gonorrhoeae typically sexually transmitted[1]. Diagnostic method. Testing the urine, urethra in males, or cervix in ... Gonorrhea is caused by the bacterium Neisseria gonorrhoeae.[15] Previous infection does not confer immunity - a person who has ... Gonorrhea, colloquially known as the clap, is a sexually transmitted infection (STI) caused by the bacterium Neisseria ... Neisseria gonorrhoeae in pus from a case of gonorrhoea in a man (Gram stain) ...
Neisseria meningitidis/meningococcus *Meningococcal disease, Waterhouse-Friderichsen syndrome, Meningococcal septicaemia. M−. * ...
Neisseria meningitidis/meningococcus *Meningococcal disease, Waterhouse-Friderichsen syndrome, Meningococcal septicaemia. M−. * ...
Neisseria meningitidis/meningococcus *Meningococcal disease, Waterhouse-Friderichsen syndrome, Meningococcal septicaemia. M−. * ...
Neisseria meningitidis colonises a substantial proportion of the general population harmlessly, but in a very small percentage ... Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed meningococcus). It has a ... Al'Aldeen AA, Cartwright KA; Cartwright (November 1996). "Neisseria meningitidis: vaccines and vaccine candidates". J. Infect. ... Ross SC, Rosenthal PJ, Berberich HM, Densen P (June 1987). "Killing of Neisseria meningitidis by human neutrophils: ...
Neisseria meningitidis/meningococcus *Meningococcal disease, Waterhouse-Friderichsen syndrome, Meningococcal septicaemia. M−. * ...
Neisseria meningitidis/meningococcus *Meningococcal disease, Waterhouse-Friderichsen syndrome, Meningococcal septicaemia. M−. * ...
... such as members of the genus Neisseria: N. gonorrhoeae and N. meninngitides being primary examples, which cause gonorrhea and ...
Neisseria gonorrhoeae Granuloma inguinale (Donovanosis) Klebsiella granulomatis Group A streptococcal infection Streptococcus ...
Neisseria meningitidis/meningococcus *Meningococcal disease, Waterhouse-Friderichsen syndrome, Meningococcal septicaemia. M−. * ...
Neisseria meningitidis/meningococcus *Meningococcal disease, Waterhouse-Friderichsen syndrome, Meningococcal septicaemia. M−. * ...
Neisseria meningitidis/meningococcus *Meningococcal disease, Waterhouse-Friderichsen syndrome, Meningococcal septicaemia. M−. * ...
Neisseria gonorrhoeae typically sexually transmitted[1]. Diagnostic method. Testing the urine, urethra in males, or cervix in ... Gonorrhea is caused by the bacterium Neisseria gonorrhoeae.[15] Previous infection does not confer immunity - a person who has ... Gonorrhea, colloquially known as the clap, is a sexually transmitted infection (STI) caused by the bacterium Neisseria ... Deguchi T, Nakane K, Yasuda M, Maeda S (September 2010). "Emergence and spread of drug resistant Neisseria gonorrhoeae". J. ...
Neisseria meningitidis/meningococcus *Meningococcal disease, Waterhouse-Friderichsen syndrome, Meningococcal septicaemia. M−. * ...
Tobiason, D. M.; Seifert, H. S. (19 February 2010). "Genomic Content of Neisseria Species". Journal of Bacteriology. 192 (8): ...
"Neisseria meningitidis". NCBI Taxonomy Browser. 487.. *Type strain of Neisseria meningitidis at BacDive - the Bacterial ... "Neisseria meningitidis". Centers for Disease Control and Prevention. 24 October 2008.. *^ "Neisseria meningitidis". Brown ... Neisseria meningitidis. Albrecht & Ghon 1901 Neisseria meningitidis, often referred to as meningococcus, is a Gram-negative ... 2010). Neisseria: Molecular Mechanisms of Pathogenesis. Caister Academic. ISBN 978-1-904455-51-6.. ...
Neisseria (family Neisseriaceae [1])* A genus of Gram-negative [2] bacteria [3] in which the cells are typically spherical and ... Neisseria (family Neisseriaceae) A genus of Gram-negative bacteria in which the cells are typically spherical and often occur ... Neisseria (ny-seer-iă) n. a genus of spherical Gram-negative aerobic nonmotile bacteria characteristically grouped in pairs. N ... Neisseria A Dictionary of Plant Sciences © A Dictionary of Plant Sciences 1998, originally published by Oxford University Press ...
Invasive meningococcal disease: isolation of Neisseria meningitidis from normally sterile site in a resident of a surveillance ... Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Neisseria meningitidis, 2009. ...
Neisseria meningitidis, a bacterium usually associated with meningitis and sepsis, is the cause of a recent cluster of sexually ... currently under development for the prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroup B ... greatly improved protective antibody responses to a new mutant vaccine antigen for prevention of disease caused by Neisseria ...
Neisseria meningitidis, a bacterium usually associated with meningitis and sepsis, is the cause of a recent cluster of sexually ... has unraveled a key stage in infection by Neisseria meningitidis, a human pathogen responsible for meningitis in infants and ... greatly improved protective antibody responses to a new mutant vaccine antigen for prevention of disease caused by Neisseria ...
Thermo Scientific™ Remel™ BactiCard™ Neisseria Uses enzyme technology for presumptive identification of Neisseria spp. and ... Rapidly detect antigens to Neisseria meningitidis group B and E. coli K1 present in human body fluids, blood cultures, or on ... Thermo Scientific™ Wellcogen™ Neisseria meningitidis A, C, Y, W135 Rapid Latex Agglutination Test Rapidly detect antigens to ... Thermo Scientific™ Remel™ Agglutinating Sera, Neisseria meningitidis Used for serological identification of N. meningitidis by ...
Neisseria is a large genus of bacteria that colonize the mucosal surfaces of many animals. Of the 11 species that colonize ...
Medical definition of Neisseria: a genus (the type of the family Neisseriaceae) of parasitic bacteria that grow in pairs and ... Resources for Neisseria. Time Traveler: Explore other words from the year Neisseria first appeared Time Traveler! Explore the ... Comments on Neisseria. What made you want to look up Neisseria? Please tell us where you read or heard it (including the quote ... Post the Definition of Neisseria to Facebook Share the Definition of Neisseria on Twitter ...
Authoritative and practical, Neisseria meningitidis: Methods and Protocols will allow for the use of these methods by more ... Meningococcus Strain analysis Vaccine development Disease progression Neisseria gonorrhoeae Host cells Editors and affiliations ... Many of these methods are applicable to the close relative, Neisseria gonorrhoeae, and several of the methods described can ... Modeling Neisseria meningitidis Infection in Mice: Methods and Logistical Considerations for Nasal Colonization and Invasive ...
Neisseria meningitidis serogroup W135. ›Neisseria meningitidis str. alpha275. ›Neisseria meningitidis strain alpha275. ...
... the continual development and application of new methods and protocols to understand the biology of the pathogen Neisseria ... Comprehensive and cutting-edge, Neisseria gonorrhoeae: Methods and Protocols provides researchers with a foundation for ... Use of Human Monocyte-Derived Macrophages to Study Neisseria gonorrhoeae Infection Jimena Gatica, Paula I. Rodas, Alejandro ... Phenotypic MicroArray Screening of Neisseria gonorrhoeae in Chemically Defined Liquid Medium Benjamin I. Baarda, Aleksandra E. ...
Neisseria polysaccharea was described in 1983 and is characterized by its ability to produce acid from glucose and maltose and ... Other Neisseria species have been be misidentified as N. polysaccharea by acid production tests and supplemental tests. ... Neisseria polysacchareais a Gram-negative diplococcus, catalase positive, culturable bacteria. It has been identified as being ... "Neisseria polysaccharea - Gonorrhea - STD Information from CDC". www.cdc.gov. Retrieved 22 August 2017. CS1 maint: discouraged ...
... , Gonococcal Infection, Gonorrhea, Gonococcus, Gonococci, Gonococcemia, Disseminated Gonococcus, Multi- ... Resistant Neisseria Gonorrhea, Gonococcal Urethritis, Gonococcal Cervicitis, Gonococcal Proctitis. ... GONOKOKKI, NEISSERIA GONORRHOEAE, ГОНОКОККИ. Spanish. Neisseria gonorrhoeae, Neisseria gonorrheae, Neisseria gonorrhoeae ( ... Gonococcus, Neisseria gonorrhoeae, Neisseria gonorrheae, N. gonorrhoeae, gonococcus, gonorrhoeae neisseria, neisseria ...
Chlamydia trachomatis,Neisseria gonorrhoeae, and Trichomonas vaginalis, NAA. TEST: 183160 Test number copied ...
Spinal Meningitis (Neisseria Meningitidis). What is Neisseria Meningitis? Neisseria Meningitis is a bacterial infection of the ... How is Neisseria Meningitis treated? It can be treated with antibiotics. It is very important that the disease be diagnosed ... The Neisseria meningitidis bacterium is usually spread through close, personal or prolonged contact with respiratory or oral ...
2018 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.. CPT Statement/Profile Statement. The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf. ...
MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Neisseria gonorrhoeae SYNONYM OR CROSS REFERENCE: Gonococcus, Gonorrhea, GC CHARACTERISTICS: Family Neisseriaceae; gram negative diplococci, intra and extra-cellular, ßlactamases plasmids (PNPG strain); infects columnar and transitional epithelium; antigenically heterogeneous SECTION II - HEALTH HAZARD PATHOGENICITY: Localized inflammatory conditions - urethritis, cervicitis, salpingitis (PID), pharyngitis of adults, vulvovaginitis in children; conjunctivitis of the newborn; septicemia may occur with lesions, bacteremia in the arthritis and dermatitis syndrome; endocarditis and meningitis; other complications include perihepatitis and neonatal amnionitis; death is rare except among those with endocarditis; reinfection is common despite development of antibodies EPIDEMIOLOGY: Common worldwide; affects both sexes and all ages; prevalent in sexually active adolescents and younger adults; incidence increasing ...
All about Meningitis (Neisseria meningitidis). FACTS: Meningitis is technically an inflammation of the meninges, or the ... There are a number of viral and bacterial causes of meningitis, but Neisseria meningitidis is the most common cause of the more ... There are a number of viral and bacterial causes of meningitis, but Neisseria meningitidis is the most common cause of the more ... 1887: Anton Weichselbaum discovered meningococcus, also known as Neisseria meningitidis, the bacterium that causes meningitis. ...
NAME: Neisseria meningitidis SYNONYM OR CROSS REFERENCE: Meningococcal meningitis, Meningococcal infection, cerebrospinal fever ...
Neisseria gonorrhoeae FA19 supercont1.10 genomic scaffold, whole genome shotgun sequence. GenBank: EQ972754.1 ...
The Neisseria gonorrhoeae pilus protein is one of the major antigenic determinants on the cells surface. It is comprised of ... Pilus expression in Neisseria gonorrhoeae involves chromosomal rearrangement.. Meyer TF, Mlawer N, So M. ...
Neisseria gonorrhoeae ATCC ® 43070™ Designation: CDC Ng-98 TypeStrain=False Application: Media testing Sexually Transmitted ... Neisseria gonorrhoeae (Zopf) Trevisan (ATCC® 43070™) Strain Designations: CDC Ng-98 / Type Strain: no / Biosafety Level: 2 ...
Neisseria gonorrhoeae ATCC ® 700825™ Designation: FA1090 TypeStrain=False Application: Sexually Transmitted Disease Research ... Neisseria gonorrhoeae (Zopf) Trevisan (ATCC® 700825D-5™) Add to dried Total DNA: At least 5 µg in 1X TE buffer. OD260/OD280: ... Quantitative Genomic DNA from Neisseria gonorrhoeae (ATCC® 700825DQ™) Add to frozen Specification range: ≥1 x 105 copies/µL. ... Neisseria gonorrhoeae (Zopf) Trevisan (ATCC® 700825™) Strain Designations: FA1090 / Type Strain: no / Biosafety Level: 2 ...
Neisseria gonorrhoeae DNA Probe,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative ...
Testing of vaginal swab specimen requires use of Aptima Multitest Swab Specimen Collection Kit. Testing of endocervical or male urethral swab specimens requires use of Aptima Unisex Swab specimen collection kit. Large white swab is for preparatory cleaning of the endocervix and is unacceptable for testing Testing of male and female urine specimens: Patient should not have urinated for at least 1 hour prior to specimen collection. Patient should collect first portion of a voided urine (first part of stream- not midstream) into a screw-capped, sterile, plastic, preservative-free specimen collection container. Do not collect more than 20mL of urine. Females should NOT clean the labial area prior to urination. Testing of throat, conjunctival, or anal/rectal swab specimens requires collection using M4 Collection Kit (swab and M4 media).Culture for Chlamydia on such nongential specimens can be ordered on the same specimen. If a GC culture is also requested see GC culture collection procedure.. ...
... Appl Microbiol. 1972 May;23(5):986-9. ...
... a Neisseria meningitidis aparece como casos esporádicos com alguns surtos sazonais locais. A notificação da infecção ... Casos de Neisseria meningitidis na Grécia * J Kremastinou1, G Tzanakaki1, N Vakalis1, A Velonaki1 ... Na Grécia, a Neisseria meningitidis aparece como casos esporádicos com alguns surtos sazonais locais. A notificação da infecção ... Casos de Neisseria meningitidis na Grécia. Euro Surveill. 1997;2(10):pii=150. https://doi.org/10.2807/esm.02.10.00150-pt ...
  • Other Neisseria species have been be misidentified as N. polysaccharea by acid production tests and supplemental tests. (wikipedia.org)
  • The bacterial genus Neisseria contains the two well-recognized pathogenic species, Neisseria gonorrhoeae and Neisseria meningitidis, which are the leading causes of bacterial meningitis and gonorrhoea worldwide. (fems-microbiology.org)
  • N. meningitidis is the only Neisseria species known to express two outer membrane porins, PorA and PorB. (ingentaconnect.com)
  • Rates of isolation of Neisseria species were also compared to those in two other geographical areas which did not have an elevated incidence of meningococcal disease. (hindawi.com)
  • 1) The majority of human-associated Neisseria species are non-pathogenic and are normal inhabitants of the upper respiratory tract. (canada.ca)
  • Individuals with underlying medical conditions and/or immune suppression or deficiency may develop serious infections caused by the normally commensal Neisseria species. (canada.ca)
  • The type species is Neisseria gonorrhoeae . (thefreedictionary.com)
  • Neisseria gonorrhoeae - a species that causes gonorrhea in humans. (thefreedictionary.com)
  • Neisseria gonorrhoeae is a species of Gram-negative, coffee bean-shaped, diplococci bacteria responsible for the sexually transmitted infection gonorrhoea. (sciencephoto.com)
  • However, in vivo animal modeling of human pharyngeal infections by pathogenic Neisseria species is challenging due to numerous host tropism barriers. (asm.org)
  • Although the pathogenic Neisseria species are considered classical extracellular pathogens, intraepithelial cell growth was documented recently, and it is possible that invasion of and growth within host cells plays an important role in pathogenesis. (asmscience.org)
  • The pathogenic Neisseria species express a wide array of iron acquisition systems. (asmscience.org)
  • Although the Neisseria species are not known to synthesize or secrete detectable siderophores, they are capable of iron acquisition from host transferrin, lactoferrin, and hemoglobin without the synthesis of a siderophore intermediate. (asmscience.org)
  • In addition to these sources of iron, the pathogenic Neisseria species are capable of using heme, siderophores made by other microorganisms (xenosiderophores), and a variety of keto acid-iron complexes as sole iron sources. (asmscience.org)
  • Model of iron acquisition systems expressed by the Neisseria species. (asmscience.org)
  • Of the eleven species of ''Neisseria'' that colonize humans, only two are pathogens. (wikidoc.org)
  • Novel Genus-Specific PCR-Based Assays for Rapid Identification of Neisseria Species and Neisseria meningitidis. (ebscohost.com)
  • This study presents the development ofpolymerase chain reaction (PCR)-based tests for the identification and detection of Neisseria species and Neisseria meningitidis. (ebscohost.com)
  • Neisseria gonorrhoeae causes gonorrhea, a sexually transmitted disease (STD) that can result in life-threatening ectopic pregnancy and infertility, and can increase the risk of getting and giving HIV. (cdc.gov)
  • Comprehensive and cutting-edge, Neisseria gonorrhoeae: Methods and Protocols provides researchers with a foundation for progress toward the eventual control of this disease and a significant reduction in global case numbers of gonorrhea. (springer.com)
  • Neisseria gonorrhoeae , also known as gonococcus , is a fastidious gram-negative diplococcus responsible for the disease gonorrhea . (conservapedia.com)
  • The emergence of resistance to azithromycin complicates treatment of Neisseria gonorrhoeae , the etiologic agent of gonorrhea. (nature.com)
  • Colour enhanced transmission electron micrograph (TEM) of Neisseria gonorrhoeae, the bacterium that causes Gonorrhea. (sciencephoto.com)
  • Neisseria gonorrhoeae causes the genital infection gonorrhea and is exposed to seminal fluid during sexual transmission. (asm.org)
  • The Detroit 562 Pharyngeal Immortalized Cell Line Model for the Assessment of Infectivity of Pathogenic Neisseria sp. (springer.com)
  • Conserved lipoprotein H.8 of pathogenic Neisseria consists entirely of pentapeptide repeats. (biomedsearch.com)
  • The pathogenic Neisseria, N. gonorrhoeae and N. meningitidis, possess an outer membrane protein (OMP), designated H.8, with a conserved monoclonal antibody (MAb)-binding epitope. (biomedsearch.com)
  • Neisseria (family Neisseriaceae ) A genus of Gram-negative bacteria in which the cells are typically spherical and often occur in pairs with adjacent sides flattened. (encyclopedia.com)
  • Neisseria meningitidis , like most other members of the Neisseriaceae family are aerobic organisms with catalase and oxidase activity. (kenyon.edu)
  • Neisseria - a genus of aerobic to facultatively anaerobic bacteria (family Neisseriaceae) that are parasites of animals. (thefreedictionary.com)
  • Genus Neisseria has a specie called Neisseria gonorhea or commonly called Gonococcus. (nursingcrib.com)
  • Neisseria meningitidis , often referred to as meningococcus , is a Gram-negative bacterium that can cause meningitis and other forms of meningococcal disease such as meningococcemia , a life-threatening sepsis . (wikipedia.org)
  • Septicaemia caused by Neisseria meningitidis has received much less public attention than meningococcal meningitis even though septicaemia has been linked to infant deaths. (wikipedia.org)
  • Neisseria meningitidis, a bacterium usually associated with meningitis and sepsis, is the cause of a recent cluster of sexually transmitted infections in Columbus, Ohio and in other US cities. (news-medical.net)
  • A study conducted by UCSF Benioff Children's Hospital Oakland Research Institute scientists shows greatly improved protective antibody responses to a new mutant vaccine antigen for prevention of disease caused by Neisseria meningitidis - also known as meningococcus - that has the potential to improve the current vaccines for meningitis. (news-medical.net)
  • The Inserm team led by Guillaume Duménil at the Institut Pasteur, in collaboration with several teams of physicists, has unraveled a key stage in infection by Neisseria meningitidis, a human pathogen responsible for meningitis in infants and young adults. (news-medical.net)
  • What is Neisseria Meningitis? (scdhec.gov)
  • Neisseria Meningitis is a bacterial infection of the fluid around spinal cord and brain. (scdhec.gov)
  • How is Neisseria Meningitis treated? (scdhec.gov)
  • Meningitis (Neisseria meningitidis) under a microscope! (giantmicrobes.com)
  • There are a number of viral and bacterial causes of meningitis, but Neisseria meningitidis is the most common cause of the more serious bacterial meningitis in children (who are most susceptible to the disease), and one of the most common in adults. (giantmicrobes.com)
  • Neisseria meningitidis is the causative agent of meningitis and meningococcal septicemia is a major cause of disease worldwide, resulting in brain damage and hearing loss, and can be fatal in a large proportion of cases. (rcsb.org)
  • Neisseria meningitidis is a parasitic, aerobic, Gram-negative, non endospore forming, nonmotile (although piliated) , coccal bacterium that is responsible for causing meningitis, inflammation of the meninges layer covering the brain. (kenyon.edu)
  • TY - JOUR T1 - Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. (unboundmedicine.com)
  • Neisseria meningitidis (the meningococcus) is primarily a commensal of the human oropharynx that sporadically causes septicemia and meningitis. (uva.nl)
  • Meningitis caused by Neisseria meningitidis is sometimes referred to as meningococcal disease. (lmh.org)
  • Neisseria meningitidis causes meningitis in about 25 out of 100 people who get the illness every year in the United States. (lmh.org)
  • Neisseria meningitidis also can cause outbreaks of meningitis. (lmh.org)
  • A case of Neisseria meningitidis, the bacteria that causes meningitis, was reported at Scotsboro Junior High School in Scottsboro, Ala., late last week. (timesfreepress.com)
  • MSNBC.com is reporting that a laboratory researcher died April 28 after becoming infected with Neisseria meningitis bacteria at the San Francisco Veterans Affairs Medical Center, according to public health officials. (infectioncontroltoday.com)
  • Neisseria meningitidis is a major causative agent, worldwide, of potentially life-threatening meningitis and septicaemia, which carry with them a high mortality rate and permanent physical and neurological issues for survivors. (springer.com)
  • The 2,272,351-base pair genome of Neisseria meningitidis strain MC58 (serogroup B), a causative agent of meningitis and septicemia, contains 2158 predicted coding regions, 1158 (53.7%) of which were assigned a biological role. (sciencemag.org)
  • A genus of small, aerobic, GRAM NEGATIVE micro-organisms occurring in pairs (diplococci) that includes Neisseria gonorrhoea , the cause of GONORRHOEA and Neisseria meningitidis the cause of epidemic cerebrospinal MENINGITIS . (thefreedictionary.com)
  • False-colour transmission electron micrograph of Neisseria meningitidis, spherical bacteria which cause meningitis in humans. (sciencephoto.com)
  • Neisseria meningitidis is an important cause of septicemia and meningitis. (jimmunol.org)
  • Neisseria meningitidis (Nm) remains a leading cause of meningitis and rapidly fatal sepsis in otherwise healthy individuals. (pnas.org)
  • Neisseria meningitidis is a leading cause of bacterial meningitis and sepsis in older children and young adults in the United States. (clinicaladvisor.com)
  • Neisseria meningitidis, the causative agent of bacterial meningitis, acquires the essential element iron from the host glycoprotein transferrin during infection through a surface transferrin receptor system composed of proteins TbpA and TbpB. (ebscohost.com)
  • Neisseria meningitidis is the principal cause of bacterial meningitis. (ebscohost.com)
  • [6] This means that laboratory tests may be less likely to confirm the presence of Neisseria meningitidis as the antibiotics will dramatically lower the number of bacteria in the body. (wikipedia.org)
  • Neisseria (ny- seer -iă) n. a genus of spherical Gram-negative aerobic nonmotile bacteria characteristically grouped in pairs. (encyclopedia.com)
  • Professor Frédéric Veyrier of the Institut national de la recherche scientifique has received $711,450 from the Canadian Institutes of Health Research for a project on bacteria of the nasopharynx, including Neisseria. (news-medical.net)
  • Neisseria is a large genus of bacteria that colonize the mucosal surfaces of many animals. (wikipedia.org)
  • Neisseria polysacchareais a Gram-negative diplococcus, catalase positive, culturable bacteria. (wikipedia.org)
  • Neisseria gonorrhoeae is a gram-negative coccus, or bacteria whose overall shape is spherical. (kenyon.edu)
  • What are the key principles of preventing gram negative bacteria - Neisseria meningitides? (clinicaladvisor.com)
  • What are the conclusions of clinical trials and meta-analyses regarding gram negative bacteria - Neisseria meningitides? (clinicaladvisor.com)
  • Neisseria meningitidis (meningococcus), a Gram-negative β-Proteobacterium (a class that includes Bordetella , Burkholderia , Kingella , and Methylomonas ), is a cause of life-threatening invasive bacterial infections, especially in young infants. (sciencemag.org)
  • This study was ap- ease were identified in Rio de Janeiro State, Brazil, all caused by serogroup C Neisseria meningitidis . (cdc.gov)
  • N. meningitidis serogroup was determined by slide agglu- he last epidemic of Neisseria meningitidis serogroup C tination with specific rabbit antisera (BD Difco, Sparks, meningococcal disease in Rio de Janeiro State, Brazil, MD, USA) or serogroup-specific PCR directly from ce- occurred in 1994. (cdc.gov)
  • A single clone, Neisseria meningitidis serogroup C (C:2a:P1.2), was isolated from seven patients during a cluster of cases of meningococcal disease in Ontario in 1989. (hindawi.com)
  • The vaccine protects against certain strains of Neisseria meningitidis . (lmh.org)
  • Fluoroquinolone-resistant strains of Neisseria gonorrhoeae have been identified frequently during the 1990s in the Far East (2). (cdc.gov)
  • The rise of extensively drug-resistant and multidrug-resistant strains of Neisseria gonorrhoeae has occurred in parallel with the increasing demand for new drugs. (asm.org)
  • Neisseria gonorrhoeae is a bacterial sexually transmitted pathogen that most commonly infects the lower genital tract, the cervix in women, and anterior urethra in men. (frontiersin.org)
  • Neisseria gonorrhoeae LOS phenotype C constitutes the first bacterial ligand to be described for the human C-type lectin receptor MGL. (biomedsearch.com)
  • Monoclonal antibodies against Neisseria gonorrhoeae: production of antibodies directed against a strain-specific cell surface antigen. (atcc.org)
  • Mapping of monoclonal antibodies specific to P64k: A common antigen of several isolates of Neisseria meningitidis. (ebscohost.com)
  • Genetic basis of Neisseria gonorrhoeae lipooligosaccharide antigenic variation. (asm.org)
  • This includes the opacity (Opa) proteins which are responsible for the opaque colony phenotype caused by tight junctions between adjacent Neisseria , and are also responsible for tight adherence to host cells. (kenyon.edu)
  • 1] Neisseria gonorrhoeae can produce one or several Opa proteins. (kenyon.edu)
  • Epitope determination of immunogenic proteins of Neisseria gonorrhoeae. (abcam.com)
  • Identification of Novel Immunogenic Proteins of Neisseria gonorrhoeae by Phage Display. (abcam.com)
  • The article presents abstracts on molecular biosciences topics discussed at the Canadian Society for Molecular Biosciences 57th Annual Meeting, including role of membrane proteins in disease, structural analysis of Neisseria meningitidis porin, and screening of membrane protein crystals. (ebscohost.com)
  • Neisseria gonorrhoeae infections are acquired by sexual contact and usually affect the mucous membranes of the urethra in males and the endocervix and urethra in females, although the infection may disseminate to a variety of tissues. (abcam.com)
  • The serovars of Neisseria gonorrhoeae that are predominant in a community change over time, a phenomenon that may be due to the development of immunity to repeat infection with the same serovar. (nih.gov)
  • People who have contact with someone with a Neisseria meningitidis infection may need to take a course of antibiotics to prevent the infection from spreading. (lmh.org)
  • The most common site of Neisseria gonorrhoeae infection is the urogenital tract. (aafp.org)
  • Neisseria gonorrhoeae is the bacterium responsible for the sexually transmitted infection gonorrhoea, also known as the clap. (sciblogs.co.nz)
  • The bug responsible, Neisseria meningitidis, is a pretty nasty one and the symptoms of infection can often be fatally mistaken for flu. (sciblogs.co.nz)
  • Erythromycin-Resistant Neisseria gonorrhoeae and Oral Commensal Neisseria spp. (asm.org)
  • Chlamydia trachomatis and Neisseria gonorrhoeae infections in women attending inner city general practices. (bmj.com)
  • Southgate L J , Treharne J D , Forsey T . Chlamydia trachomatis and Neisseria gonorrhoeae infections in women attending inner city general practices. (bmj.com)
  • We used the hybrid capture assays to investigate the prevalence of human papillomavirus (HPV), Chlamydia trachomatis and Neisseria gonorrhoeae among commercial sex workers in Tokyo. (hindawi.com)
  • PID is often caused by sexually transmitted organisms, most commonly Chlamydia trachomatis and Neisseria gonorrhoeae . (questdiagnostics.com)
  • This report compares laboratory surveillance data for Neisseria gonorrhoeae isolates submitted by provincial microbiology laboratories to the National Microbiology Laboratory (NML) from 2011-2015. (canada.ca)
  • Microbiology == ''[[Neisseria]]'' are fastidious Gram-negative cocci that require nutrient supplementation to grow in laboratory cultures. (wikidoc.org)
  • The metabolism of glucose was examined in several clinical isolates of Neisseria gonorrhoeae . (asm.org)
  • Gonococci isolates from 65 patients in São Paulo were submitted to susceptibility testing, and a decreased susceptibility or resistance to ciprofloxacin was observed in 8.7% of these patients, indicating that Neisseria gonorrhoeae fluoroquinolone resistance is emerging in Brazil. (scielo.br)
  • Antibiotic resistance in Neisseria gonorrhoeae (GC) has become an emerging threat worldwide and heightens the need for monitoring treatment failures. (mdpi.com)
  • Research characterizing the mechanisms of pathogenesis and transmission of Neisseria gonorrhoeae is important for developing new prevention strategies, since antibiotic resistance of the organism is becoming increasingly prevalent. (asm.org)
  • Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses. (biomedsearch.com)
  • The Neisseria gonorrhoeae pilus protein is one of the major antigenic determinants on the cell's surface. (nih.gov)
  • Neisseria gonorrhoeae suppresses exfoliation by stimulating epithelial cells to produce endoglin (ENG, also known as CD105), a matrix-binding protein that is normally produced by endothelial cells. (sciencemag.org)
  • P64k is a minor outer membrane protein from Neisseria meningitidis. (ebscohost.com)
  • If you are planning foreign travel, particularly to sub-Saharan Africa, talk with a doctor about getting the Neisseria meningitidis vaccine. (lmh.org)
  • The intimate relationship between humans and Neisseria gonorrhoeae infections span centuries, which is evidenced in case reports from studies dating back to the late 1700s and historical references that predate medical literature. (frontiersin.org)
  • Rapidly detect antigens to Neisseria meningitidis groups A, C, Y, W135 present in human body fluids or blood cultures by latex agglutination. (fishersci.com)
  • Rapidly detect antigens to Neisseria meningitidis group B and E. coli K1 present in human body fluids, blood cultures, or on culture media by latex agglutination. (fishersci.com)
  • Reacts to all antigens of Neisseria gonorrhoeae. (abcam.com)
  • This antibody reacts with all Neisseria Meningitidis antigens (Types A, B, C). May react with related microbes. (fishersci.com)
  • This antibody reacts with Neisseria meningitidis serogroups A, B and C and is thought to recognize all antigens. (antibodies-online.com)
  • Neisseria gonorrhoeae culture test is done to detect the presence of the gram negative, coffee bean - shaped bacterium, Neisseria gonorrhoeae. (medindia.net)
  • Neisseria meningitidis është një bakter gram negativ. (wikipedia.org)
  • Neisseria meningitidis is a gram negative, encapsulated bacterium which at any time colonizes the upper respiratory tract of ∼10% of human population. (rupress.org)
  • The Neisseria meningitidis organisms are gram negative, aerobic diplococcic that can attach to the surface of mucosal cells of the nasopharynx. (clinicaladvisor.com)
  • Neisseria gonorrhoeae FA 1090, complete genome. (atcc.org)
  • Neisseria gonorrhoeae have a circular DNA genome. (kenyon.edu)
  • By genome mining, we discovered GNA1870, a new surface-exposed lipoprotein of Neisseria meningitidis that induces high levels of bactericidal antibodies. (rupress.org)
  • Neisseria gonorrhoeae (GC) infects epithelial cells lining the female reproductive tract. (umd.edu)
  • We must fear a diffusion of extensively drug-resistant Neisseria gonorrhoeae in the future. (sigmaaldrich.com)
  • Decreased susceptibility of Neisseria meningitidis iso- chial rash, neck stiffness, and altered sensory functions. (cdc.gov)
  • Many of these methods are applicable to the close relative, Neisseria gonorrhoeae , and several of the methods described can also be used in investigating host-pathogen interactions for a range of other organisms. (springer.com)
  • Authoritative and practical, Neisseria meningitidis: Methods and Protocols will allow for the use of these methods by more laboratories and foster collaboration and consistency in investigations of this enigmatic and dangerous pathogen. (springer.com)
  • This detailed book addresses the continual development and application of new methods and protocols to understand the biology of the pathogen Neisseria gonorrhoeae . (springer.com)
  • Background: Survival of the human pathogen, Neisseria meningitidis, requires an effective response to oxidative stress resulting from the release of hydrogen peroxide by cells of the human immune system. (ebscohost.com)
  • The global threat of antimicrobial resistance (AMR) has emphasized the need to better understand the biology of Neisseria for future therapeutic solutions. (fems-microbiology.org)