The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.
Focal accumulations of EDEMA fluid in the NASAL MUCOSA accompanied by HYPERPLASIA of the associated submucosal connective tissue. Polyps may be NEOPLASMS, foci of INFLAMMATION, degenerative lesions, or malformations.
The scroll-like bony plates with curved margins on the lateral wall of the NASAL CAVITY. Turbinates, also called nasal concha, increase the surface area of nasal cavity thus providing a mechanism for rapid warming and humidification of air as it passes to the lung.
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.
Fluid obtained by THERAPEUTIC IRRIGATION or washout of the nasal cavity and NASAL MUCOSA. The resulting fluid is used in cytologic and immunologic assays of the nasal mucosa such as with the NASAL PROVOCATION TEST in the diagnosis of nasal hypersensitivity.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Disorders of the nose, general or unspecified.
The partition separating the two NASAL CAVITIES in the midplane. It is formed by the SEPTAL NASAL CARTILAGE, parts of skull bones (ETHMOID BONE; VOMER), and membranous parts.
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.
A part of the upper respiratory tract. It contains the organ of SMELL. The term includes the external nose, the nasal cavity, and the PARANASAL SINUSES.
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
Delivery of medications through the nasal mucosa.
Tumors or cancer of the NOSE.
Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)
The sudden, forceful, involuntary expulsion of air from the NOSE and MOUTH caused by irritation to the MUCOUS MEMBRANES of the upper RESPIRATORY TRACT.
Application of allergens to the nasal mucosa. Interpretation includes observation of nasal symptoms, rhinoscopy, and rhinomanometry. Nasal provocation tests are used in the diagnosis of nasal hypersensitivity, including RHINITIS, ALLERGIC, SEASONAL.
Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.
That portion of the nasal mucosa containing the sensory nerve endings for SMELL, located at the dome of each NASAL CAVITY. The yellow-brownish olfactory epithelium consists of OLFACTORY RECEPTOR NEURONS; brush cells; STEM CELLS; and the associated olfactory glands.
The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA.
Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.
Any hindrance to the passage of air into and out of the nose. The obstruction may be unilateral or bilateral, and may involve any part of the NASAL CAVITY.
Skin irritant and allergen used in the manufacture of polyurethane foams and other elastomers.
A light and spongy (pneumatized) bone that lies between the orbital part of FRONTAL BONE and the anterior of SPHENOID BONE. Ethmoid bone separates the ORBIT from the ETHMOID SINUS. It consists of a horizontal plate, a perpendicular plate, and two lateral labyrinths.
Technique for measuring air pressure and the rate of airflow in the nasal cavity during respiration.
Either one of the two small elongated rectangular bones that together form the bridge of the nose.
Air-filled spaces located within the bones around the NASAL CAVITY. They are extensions of the nasal cavity and lined by the ciliated NASAL MUCOSA. Each sinus is named for the cranial bone in which it is located, such as the ETHMOID SINUS; the FRONTAL SINUS; the MAXILLARY SINUS; and the SPHENOID SINUS.
A chronic inflammation in which the NASAL MUCOSA gradually changes from a functional to a non-functional lining without mucociliary clearance. It is often accompanied by degradation of the bony TURBINATES, and the foul-smelling mucus which forms a greenish crust (ozena).
An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.
Pharmacologic agents delivered into the nostrils in the form of a mist or spray.
A plant genus of the family ASTERACEAE. The POLLEN is one cause of HAYFEVER.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.
Hyaline cartilages in the nose. There are five major nasal cartilages including two lateral, two alar, and one septal.
The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)
The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.
Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use.
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Diagnostic measurement of the nose and its cavity through acoustic reflections. Used to measure nasal anatomical landmarks, nasal septal deviation, and nasal airway changes in response to allergen provocation tests (NASAL PROVOCATION TESTS).
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
The fertilizing element of plants that contains the male GAMETOPHYTES.
A form of non-allergic rhinitis that is characterized by nasal congestion and posterior pharyngeal drainage.
A skin and mucous membrane disease characterized by an eruption of macules, papules, nodules, vesicles, and/or bullae with characteristic "bull's-eye" lesions usually occurring on the dorsal aspect of the hands and forearms.
Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Proteins found in EOSINOPHIL granules. They are primarily basic proteins that play a role in host defense and the proinflammatory actions of activated eosinophils.
A genus of gram-negative, aerobic bacteria whose cells are minute coccobacilli. It consists of both parasitic and pathogenic species.
Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.
Surgical operations on the nose and nasal cavity.
Irrigation of the nose with saline or irrigation solutions for diagnostic or therapeutic purposes. It is used to remove irritants, allergens, or microorganisms from the nose.
A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.
An order of MAMMALS, usually flesh eaters with appropriate dentition. Suborders include the terrestrial carnivores Fissipedia, and the aquatic carnivores PINNIPEDIA.
Modified oligonucleotides in which one of the oxygens of the phosphate group is replaced with a sulfur atom.
Infections with bacteria of the genus PASTEURELLA.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers.
A disease characterized by the chronic, progressive spread of lesions from New World cutaneous leishmaniasis caused by species of the L. braziliensis complex to the nasal, pharyngeal, and buccal mucosa some time after the appearance of the initial cutaneous lesion. Nasal obstruction and epistaxis are frequent presenting symptoms.

Zonula occludens toxin is a powerful mucosal adjuvant for intranasally delivered antigens. (1/1918)

Zonula occludens toxin (Zot) is produced by toxigenic strains of Vibrio cholerae and has the ability to reversibly alter intestinal epithelial tight junctions, allowing the passage of macromolecules through the mucosal barrier. In the present study, we investigated whether Zot could be exploited to deliver soluble antigens through the nasal mucosa for the induction of antigen-specific systemic and mucosal immune responses. Intranasal immunization of mice with ovalbumin (Ova) and recombinant Zot, either fused to the maltose-binding protein (MBP-Zot) or with a hexahistidine tag (His-Zot), induced anti-Ova serum immunoglobulin G (IgG) titers that were approximately 40-fold higher than those induced by immunization with antigen alone. Interestingly, Zot also stimulated high anti-Ova IgA titers in serum, as well as in vaginal and intestinal secretions. A comparison with Escherichia coli heat-labile enterotoxin (LT) revealed that the adjuvant activity of Zot was only sevenfold lower than that of LT. Moreover, Zot and LT induced similar patterns of Ova-specific IgG subclasses. The subtypes IgG1, IgG2a, and IgG2b were all stimulated, with a predominance of IgG1 and IgG2b. In conclusion, our results highlight Zot as a novel potent mucosal adjuvant of microbial origin.  (+info)

Morphology of intraepithelial corpuscular nerve endings in the nasal respiratory mucosa of the dog. (2/1918)

Corpuscular nerve endings in the nasal respiratory mucosa of the dog were investigated by immunohistochemical staining specific for protein gene product 9.5 by light and electron microscopy. In the nasal respiratory mucosa, complex corpuscular endings, which displayed bulbous, laminar and varicose expansions, were distributed on the dorsal elevated part of the nasal septum and on the dorsal nasal concha. The endings were 300-500 microm long and 100-250 microm wide. Some axons gave rise to a single ending while others branched into 2 endings. Cryostat sections revealed that the corpuscular endings were located within the nasal respiratory epithelium. On electron microscopy, immunoreactive nerve terminals that contained organelles, including mitochondria and neurofilaments, were observed within the epithelial layer near the lumen of the nasal cavity. Some terminals contacted the goblet cell. Such terminal regions were covered by the cytoplasmic process of ciliated cells and were never exposed to the lumen of the nasal cavity. These nerve endings are probably activated by pressure changes.  (+info)

Trigeminal and carotid body inputs controlling vascular resistance in muscle during post-contraction hyperaemia in cats. (3/1918)

1. In anaesthetized cats, the effects of stimulation of the receptors in the nasal mucosa and carotid body chemoreceptors on vascular resistance in hindlimb skeletal muscle were studied to see whether the responses were the same in active as in resting muscle. The measurements of vascular resistance were taken, first, in resting muscle, and second, in the immediate post-contraction hyperaemic phase that followed a 30 s period of isometric contractions. 2. Stimulation of the receptors in the nasal mucosa caused reflex apnoea and vasoconstriction in muscle. The latter response was attenuated when the test was repeated during post-contraction hyperaemia. 3. Stimulations of the carotid bodies were made during a period of apnoea evoked reflexly by electrical stimulation of both superior laryngeal nerves. This apnoea prevented any effects of changes in respiration on the carotid body reflex vascular responses. Stimulation of the carotid bodies evoked hindlimb muscle vasoconstriction. In the post-contraction hyperaemic period, the response was reduced or abolished. A similar attenuation of the reflex vasoconstrictor responses occurred in decentralized muscles stimulated through their motor roots in the cauda equina. 4. Evidence is presented that the attenuation of the vasoconstrictor responses evoked by the two reflexes is a phenomenon localized to the contracting muscles themselves resulting from an interaction between sympathetic neuronal activity and the local production of metabolites. 5. The results are discussed in relation to the metabolic needs of tissues in relation to asphyxial defence mechanisms such as occur in the diving response.  (+info)

Immunoglobulin-specific radioimmunoprecipitation assays for quantitation of nasal secretory antibodies to hemagglutinin of type A influenza viruses. (4/1918)

Radioimmunoprecipitation (RIP) assays were developed to selectively quantitate class-specific antibodies to purified hemagglutinins (HA) of type A influenza virus in nasal secretions. Rabbit anti-human secretory piece of immunoglobulin A (IgA) and rabbit anti-human IgG were used as second antibodies. A third antibody, goat anti-rabbit IgG, was incorporated into the system to separate immune complexes formed between iodinated HA, nasal wash test specimen, and second antibody. The utilization of this reagent avoided the need for large quantities of IgA and IgG antibody-negative carrier secretions. Nasal was specimens obtained from 14 adults immunized with an inactivated type A influenza virus vaccine were evaluated by RIP and viral neutralization assays. Significant homologous postvaccination secretory IgA and IgG antibody levels were demonstrable in 13 (93%) of individuals by RIP, whereas only 5 (36%) exhibited rises by viral neutralization tests. Moreover, the geometric mean IgA and IgG antibody levels were at least 20- and 37-fold greater than the neutralizing antibody titer. The pattern of heterologous immunoglobulin-specific antibody responses tended to be similar to those observed with the homologous HA subunit.  (+info)

Glycoconjugate expression in follicle-associated epithelium (FAE) covering the nasal-associated lymphoid tissue (NALT) in specific pathogen-free and conventional rats. (5/1918)

We examined lectin-histochemically the glycoconjugate expression in the follicle-associated epithelium (FAE) covering the nasal-associated lymphoid tissue (NALT) in the rat under specific pathogen-free (SPF) and conventional (CV) conditions and compared the results for SPF and CV rats as well as for membranous (M) cells and adjacent ciliated respiratory epithelial (CRE) cells in FAE. N-acetylgalactosamine-specific lectins, Dolichos biflorus (DBA), Helix pomatia (HPA), Glycine max (SBA) and Vicia villosa (VVA), and alpha-L-fucose-specific lectin, Ulex europaeus (UEA-I), preferentially bound to M cells mainly in the luminal surface compared with CRE cells in SPF rats, whereas DBA and UEA-I showed signs of preferential binding to the apical and basolateral cytoplasm as well as to the luminal surface of M cells in CV rats. In addition, HPA, SBA and VVA more frequently and extensively labeled M cells than CRE cells in CV rats with the same subcellular staining pattern as DBA and UEA-I. On the whole, the changes in lectin binding frequency and strength were more prominent in M cells than in CRE cells in both SPF and CV rats. The present results indicate that DBA and UEA-I are useful as markers of M cells in NALT. Furthermore, the pattern of expression of carbohydrate residues recognized by such lectins in SPF and CV rats suggests that M cells are highly sensitive to environmental changes.  (+info)

Anatomical structure and surface epithelial distribution in the nasal cavity of the common cotton-eared marmoset (Callithrix jacchus). (6/1918)

To validate use of the common cotton-eared marmoset (Callithrix jacchus) in inhalation toxicity studies, its nasal morphology was examined. The nasal turbinates each consisted of one maxilloturbinate and one ethmoturbinate: these were more planar in structure than the comparable structures of rodents or dogs. The nasal cavity epithelia comprised squamous epithelium (SE), nasal transitional epithelium (NTE), respiratory epithelium (RE) and olfactory epithelium (OE), listed in order of occurrence from anterior to posterior positions. NTE was distributed as a narrow band lying between SE and RE. OE was limited to the dorsal part of the cavity, which was structurally similar to that of the macaque or man. Overall, this study revealed structural the similarity of the whole nasal cavity in the marmoset to that of macaques or humans. Prediction of nasal cavity changes in man based on extrapolation from experimentally induced changes in the common marmoset therefore seems likely to be feasible, making it a useful animal model for inhalation studies.  (+info)

Nitric oxide-mediated regulation of transepithelial sodium and chloride transport in murine nasal epithelium. (7/1918)

Transepithelial ion transport is regulated by a variety of cellular factors. In light of recent evidence that nitric oxide (NO) production is decreased in cystic fibrosis airways, we examined the role of NO in regulating sodium and chloride transport in murine nasal epithelium. Acute intervention with the inducible NO synthase (iNOS)-selective inhibitor S-methylisothiourea resulted in an increase of amiloride-sensitive sodium absorption observed as a hyperpolarization of nasal transepithelial potential difference. Inhibition of iNOS expression with dexamethasone also hyperpolarized transepithelial potential difference, but only a portion of this increase proved to be amiloride sensitive. Chloride secretion was significantly inhibited in C57BL/6J mice by the addition of both S-methylisothiourea and dexamethasone. Mice lacking iNOS expression [NOS2(-/-)] also had a decreased chloride-secretory response compared with control mice. These data suggest that constitutive NO production likely plays some role in the downregulation of sodium absorption and leads to an increase in transepithelial chloride secretion.  (+info)

The rostral ventrolateral medulla mediates the sympathoactivation produced by chemical stimulation of the rat nasal mucosa. (8/1918)

1. We sought to outline the brainstem circuit responsible for the increase in sympathetic tone caused by chemical stimulation of the nasal passages with ammonia vapour. Experiments were performed in alpha-chloralose-anaesthetized, paralysed and artificially ventilated rats. 2. Stimulation of the nasal mucosa increased splanchnic sympathetic nerve discharge (SND), elevated arterial blood pressure (ABP), raised heart rate slightly and inhibited phrenic nerve discharge. 3. Bilateral injections of the broad-spectrum excitatory amino acid receptor antagonist kynurenate (Kyn) into the rostral part of the ventrolateral medulla (RVLM; rostral C1 area) greatly reduced the effects of nasal mucosa stimulation on SND (-80 %). These injections had no effect on resting ABP, resting SND or the sympathetic baroreflex. 4. Bilateral injections of Kyn into the ventrolateral medulla at the level of the obex (caudal C1 area) or into the nucleus tractus solitarii (NTS) greatly attenuated the baroreflex and significantly increased the baseline levels of both SND and ABP. However they did not reduce the effect of nasal mucosa stimulation on SND. 5. Single-unit recordings were made from 39 putative sympathoexcitatory neurons within the rostral C1 area. Most neurons (24 of 39) were activated by nasal mucosa stimulation (+65.8 % rise in discharge rate). Responding neurons had a wide range of conduction velocities and included slow-conducting neurons identified previously as C1 cells. The remaining putative sympathoexcitatory neurons were either unaffected (n = 8 neurons) or inhibited (n = 7) during nasal stimulation. We also recorded from ten respiratory-related neurons, all of which were silenced by nasal stimulation. 6. In conclusion, the sympathoexcitatory response to nasal stimulation is largely due to activation of bulbospinal presympathetic neurons within the RVLM. We suggest that these neurons receive convergent and directionally opposite polysynaptic inputs from arterial baroreceptors and trigeminal afferents. These inputs are integrated within the rostral C1 area as opposed to the NTS or the caudal C1 area.  (+info)

TY - JOUR. T1 - Effects of cocaine on human nasal mucosa. AU - Wang, S. H.. AU - Wang, H. W.. AU - Wang, J. Y.. PY - 1993/7. Y1 - 1993/7. N2 - The effects of cocaine on the contractile response of isolated human nasal mucosal blood vessels to field stimulation and methoxamine were investigated. Results showed that cocaine antagonized methoxamine and inhibited field stimulation. The drug increased resting tension in human nasal mucosa in vitro through direct actions and potentiated mucosal contractions by norepinephrine and epinephrine. The study indicated that high concentrations of cocaine may actually antagonize α-adrenoceptors, but these concentrations are not necessary in eliciting desired degrees of vasoconstriction in nasal blood vessels while being applied as a local anesthetic.. AB - The effects of cocaine on the contractile response of isolated human nasal mucosal blood vessels to field stimulation and methoxamine were investigated. Results showed that cocaine antagonized methoxamine ...
Phospholipase A2 (PLA2) is a superfamily of enzymes that promote inflammation by releasing arachidonic acid for the synthesis of eicosanoids and lysophospholipid for the synthesis of platelet-activating factor (PAF). On the other hand, several members of the PLA2 family (VIIA, VIIB, VIIIA and VIIIB) are able to degrade PAF and are therefore potentially important anti-inflammatory enzymes. The precise roles of the different PLA2 enzymes in airways inflammation are not known and the gene expression of the different PLA2s in the human nasal mucosa has not previously been examined. Using reversed transcription-polymerase chain reaction (RT-PCR) techniques, this thesis investigated (i) the occurrence of mRNAs for different PLA2 types in the nasal mucosa of healthy subjects; (ii) the effects of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) on the gene expression of different PLA2s in human nasal epithelial cells (RPMI 2650); (iii) the effects of IFN-γ and lipopolysaccharide (LPS) on ...
TY - JOUR. T1 - Surface-functionalized nanoparticles for targeted gene delivery across nasal respiratory epithelium. AU - Sundaram, Sneha. AU - Roy, Shyamal K. AU - Ambati, Balamurali K.. AU - Kompella, Uday B.. PY - 2009/11/5. Y1 - 2009/11/5. N2 - The objective of this study was to determine whether surface-modified nanoparticles enhance permeability across nasal mucosa, while retaining the effectiveness of the payload. The uptake and permeability of polystyrene nanoparticles (PS-NPs; Fluo-Spheres) was evaluated across the various regions of the bovine nasal epithelia following conjugation with deslorelin and transferrin. Uptake and transport of PS-NPs, deslorelin-PS-NPs, and transferrin-PS-NPs exhibited regional differences in the order: inferior turbinate posterior (ITP) , medium turbinate posterior (MTP) , medium turbinate anterior (MTA). Uptake and transport also exhibited directionality and temperature dependence in these tissues. Further, uptake as well as transport of functionalized ...
Epithelial cells are uniquely positioned at the interface between inside and outside of the organism, which makes them perfect candidates for initiating and orchestrating local immune responses. In addition to establishing which TLR receptors are expressed in primary nasal epithelial cells from healthy individuals, our data furthermore suggest that nasal epithelium has developed a delicate response system towards microbial exposures. Firstly, despite the presence of TLR4 and its prime co-stimulatory molecules CD14 and MD-2, nasal epithelium from healthy individuals does not respond to LPS. As the nasal mucosa is constantly exposed to high concentrations of endotoxin, this unresponsiveness could provide a mechanism to dampen the inflammatory response in the nasal mucosa in order to avoid a chronic inflammatory response. Secondly, levels of TLR expression in individuals varies strongly, to the extent that some individuals not express TLRs that others do. Thirdly, not only are the expression levels ...
Background: Nasal potential difference (NPD) test has long been used to assist in the diagnosis of Cystic Fibrosis (CF) and more recently as an outcome measure in clinical trials of new CF therapies. This test has also been adapted to the mouse nose. Objectives: We aimed at evaluating variability of the NPD measurements in CF patients displaying two severe CFTR mutations and in sex-matched healthy controls. NPD recorded from F508del-CF and normal wild-type mice were also compared. Methods and results: In each setting, tests were performed by a single qualified operator. In the clinical setting, the latest standardized operation protocol of the CF foundation was followed. A total of 80 tracings were obtained from 10 patients (23.2 y; range 14 to 32) and 10 healthy subjects (34 y; range 24 to 53), each tested twice, in both nostrils. Two CF and two controls were excluded from the statistical data analysis due to the presence of a single non interpretable NPD tracing (4/80, 5%). To achieve equal sample
Endobronchial and nasal mucosa biopsies were obtained from 5 patients with clinically-stable, diagnosed asthma (ATS criteria). A comparison was made of the presence and distribution of immunocompetent lymphocytes and macrophages within each sample. The distribution of immunocompetent cells within the nasal biopsies of the asthmatic patients reflected a very similar inflammatory infiltrate to that seen in the bronchial biopsies. Significantly raised numbers of T lymphocytes, CD45RO + lymphocytes, RFD1 + macrophage-like cells and RFD7 + macrophages were seen in both the nasal mucosa and the bronchial biopsies. Increases in HLA-DR expression were also seen in the nasal mucosa biopsies from asthmatics although the increases over normal did not reach statistical significance. It is concluded that inflammation present in the nasal mucosa of asymptomatic asthmatics exhibits cellular characteristics also seen in endobronchial biopsies. This observation offers the possibility that mucosal biopsy may be ...
The immune system has evolved to use sophisticated mechanisms to recruit lymphocytes to sites of pathogen exposure. Trafficking pathways are precise. For example, lymphocytes that are primed by gut pathogens can, in some cases, be imprinted with CCR9 membrane receptors, which can influence migration to the small intestine. Currently, little is known about T cell trafficking to the upper respiratory tract or the relationship between effectors that migrate to the diffuse nasal-associated lymphoid tissue (d-NALT), the lower airways, and the lung. To determine whether a T cell primed by Ag from a respiratory pathogen is imprinted for exclusive trafficking to the upper or lower respiratory tract or whether descendents from that cell have the capacity to migrate to both sites, we inoculated mice by the intranasal route with Sendai virus and conducted single-cell-sequencing analyses of CD8+ T lymphocytes responsive to a Kb-restricted immunodominant peptide, FAPGNYPAL (Tet+). Cells from the d-NALT, lung ...
Effect of Sample Storage Temperature on ciliary Beat Frequency of Flow Subjected Cilia. Sijumbila, Gibson; Mehta, Anil // Journal of Medical Science & Technology;Sep2015, Vol. 4 Issue 3, p196 The aim of this study was to determine the optimal temperature for storage and subsequent measurement of the ciliary beat frequency (CBF) of cells brushed from human nasal epithelium. In each case, human nasal epithelial cells were stored at 4, 20 or 32°C and CBF measured at 20 or 32°C.... ...
Nasopharynx surface, coloured scanning electron micrograph (SEM). Shown hear are tiny microvilli on the surface of a squamous nasal epithelial cell. The nasopharynx (nasal part of the pharynx) lies behind the nose and above the level of the soft palate. Stratified squamous nasal epithelial cells line the surface of the nasopharynx. The epithelial cell surfaces are covered with tiny microvilli that increase the cell surface area. The microvilli likely aid in localization of foreign debris (coming from the nose) and detection by immune cells. Mucus, secreted by cells in the epithelial lining (not seen), traps foreign objects, such as bacteria, preventing them from entering the lungs. Other sensory cells and features (not seen) also occur in the nasal epithelial layer. Magnification: x8,000 when shortest axis printed at 25 millimetres. - Stock Image C031/9876
The nasal mucosa is the tissue that lines the nasal cavity, which is made up of four layers. The main purpose of the nasal mucosa...
The freeMD virtual doctor has found 1 condition that can cause Itchy Nasal Mucosa and Multiple Joints. There is 1 somewhat common condition that can cause Itchy Nasal Mucosa and Multiple Joints.
With each passing year, there is a dramatic rise in the number of nasal allergy cases all around the world with one out of four people suffering from either seasonal or chronic allergy. Nasal allergies are said to be the most common respiratory illnesses and are not only mildly irritating but also hard to live with.. Nasal allergies are also known as allergic rhinitis and they come with numerous symptoms. It has been established that most nasal allergies occur when the bodys immune system rejects substances taken in from the air that we breathe and starts attacking them. During its process of rejecting, the immune system releases substances called histamines and leukotrienes which in turn cause inflammation of the nasal lining.. Some of the most common symptoms of nasal allergies are:. ...
Introduction and objectives: Pollen grains released by plants are dispersed into the air and can become trapped in human nasal mucosa, causing immediate release of allergens triggering severe Type 1 hypersensitivity reactions in susceptible allergic patients. Recent epidemiologic data show that...
The epithelium of the nasal mucosa is of two types - respiratory epithelium, and olfactory epithelium differing according to its functions. In the respiratory region it is columnar and ciliated.[3] Interspersed among the columnar cells are goblet or mucin cells, while between their bases are found smaller pyramidal cells. Beneath the epithelium and its basement membrane is a fibrous layer infiltrated with lymph corpuscles, so as to form in many parts a diffuse adenoid tissue, and under this a nearly continuous layer of small and larger glands, some mucous and some serous, the ducts of which open upon the surface. In the olfactory region the mucous membrane is yellowish in color and the epithelial cells are columnar and non-ciliated; they are of two kinds, supporting cells and olfactory cells. The supporting cells contain oval nuclei, which are situated in the deeper parts of the cells and constitute the zone of oval nuclei; the superficial part of each cell is columnar, and contains granules of ...
Nasopharynx surface, animated coloured scanning electron micrograph (SEM). Seen here are: squamous nasal epithelial cells, a ciliated nasal epithelial cell and an M cell (lymphoepithelium). The nasopharynx lies behind the nose and above the level of the soft palate. Stratified squamous nasal epithelial cells line the surface of the nasopharynx (tightly packed together in this image). The epithelial cell surfaces are covered with microvilli that increase the cell surface area. Mucus, secreted by cells in the epithelial lining (not seen), traps foreign objects, preventing them from entering the lungs. Near the centre of the image is a ciliated nasal epithelial cell. They have hair-like structures known as cilia. Coordinated, beating of the cilia propels the mucus to the back of the pharynx, where it is swallowed. The M-cell is part of the lymphoepithelium and aids in transporting foreign antigens to the underlying lymphoid follicles. Magnification: x1, 200 ...
Background. CFTR gene sequencing enhances the detection rate of molecular analysis but it frequently identifies mutations of uncertain significance for which it is difficult to define the pathogenic role without complex functional studies that require in vitro expression of the mutation.. Hypothesis and objectives. Set up and validate the sampling, culture and analysis of nasal epithelial cells using a series of techniques to study the effect of mutations in a novel ex-vivo model specifically obtained from the patient bearing the novel mutation.. ...
Acute respiratory illness is the leading cause of asthma exacerbations yet the mechanisms underlying this association remain unclear. To address the deficiencies in our understanding of the molecular events characterizing acute respiratory illness-induced asthma exacerbations, we undertook a transcriptional profiling study of the nasal mucosa over the course of acute respiratory illness amongst individuals with a history of asthma, allergic rhinitis and no underlying respiratory disease. Transcriptional profiling experiments were performed using the Agilent Whole Human Genome 4X44K array platform. Time point-based microarray and principal component analyses were conducted to identify and distinguish acute respiratory illness-associated transcriptional profiles over the course of our study. Gene enrichment analysis was conducted to identify biological processes over-represented within each acute respiratory illness-associated profile, and gene expression was subsequently confirmed by quantitative
Mental disorders during Cocainum use. Narcomaniacs usually smell cocainum, it is easily soaked up in a blood through a nasal mucosa. At intravenous injection the influence of a narcotic is stronger. Cocainum causes revaluation of the opportunities, often there are crazy ideas, hallucinations as a result of which [...]. ...
ICD-10-PCS code 09JKXZZ for Inspection of Nasal Mucosa and Soft Tissue, External Approach is a medical classification as listed by WHO under the range
Nasal Mucosa,Medical Illustration database of the best portfolios and stock images now features General and Commercial Illustration and illustrators. 8,000+ image database includes all types of subjects and features the largest directory of medical, science, and nature illustrators and illustration on the web.
Illustration of the human nasal passage with an enlarged section showing its histology. The nasal cavity forms part of the system of airways that conducts air to and from the lungs. The walls of the conducting airways are supported by cartilage and bone which prevents their collapse during ventilation. The inner lining consists of pseudostratified, columnar, ciliated epithelium (with oval, purple nuclei) interspersed with mucous- & hormone-secreting goblet cells (blue). The underlying lamina propria is rich in blood vessels & houses serous & mucous glands; some appear circular in transverse section, with one large central gland shown in longitudinal section. - Stock Image P414/0007
In addition, the saponins stimulate the sensitive receptors present in the nasal mucosa, inducing a nociceptive response transmitted by the trigeminal nerve. The nasal mucosa is entirely innervated by the trigeminal nerve, and therefore the cholinergic response generated in the nasal cavity is observed throughout the nasal mucosa, favouring opening of the ostium, increasing glandular secretions and increasing ciliar movement in the entire area. The accumulated secretions in the sinuses are consequently drained through the nose, providing rapid symptomatic relief of nasal congestion ...
Semax is applied intranasally. Memory impairment - 3 drops in each nasal passage 2 times a day for 10 days, 2 courses per year are recommended. Chronic brain ischemia, astheno-neurotic disorders - 3 drops in each nasal passage for 16 days, 2-4 courses per year are recommended. Prevention of stroke and TIA - 3 drops in each nasal passage 2 times a day for 10 days, 2 courses per year are recommended. The recovery period after a stroke and TIA - 4 drops in each nasal passage 6 times a day for 16 days. Prevention (prevention) of recurrent strokes and TIA - 3 drops in each nasal passage 3 times a day for 16 days, 2-3 courses per year are recommended. Traumatic brain injuries and neurosurgical operations - 3 drops in each nasal passage 3 times a day for 16 days, a repeated course is recommended after 6 months. Treatment of post-narcotic disorders of memory and attention - 3 drops in each nasal passage 3 times a day for 6 days. Minimal cerebral dysfunctions in children, including attention deficit ...
A stuffed nose can be the result of swelling of the nasal mucosa, secretion in the nose, polyps or other outgrowths, rarely foreign bodies or other conditions (for instance, in case of diseases of the nerve fibres of the nasal mucosa, the nose may feel stuffed although the breathing space is sufficient).. Stuffing (obstruction) may exist in the nose, but also in the nasal part of the pharynx, so that during examination not only the nose, but also the nasal part of the throat has to be examined.. In this case also the ear has to be examined, as the function of the nose canal so affect the middle ear.. Further, the examination includes the oral cavity and oral and lower part of the throat. In this way it is possible to detect a suspect laryngo-pharyngeal reflux, which canal so cause changes of the nasal mucosa.. Endoscopic examination may also be necessary.. ...
This study provides evidence that lipids are secreted to mucosal surfaces and contribute to the inherent antimicrobial activity of mucosal secretions. To examine the potential role of lipids in innate mucosal host defense, we used nasal mucosal secretions. Nasal mucosa is a primary microbial exposure site; nasal mucosa is not exposed to alimentary lipids, its secretions are easily accessible and its antibacterial activity has been previously established in respect to antimicrobial polypeptides (27).. We found all major lipid classes in nasal fluid collected from healthy adults and, to our knowledge, this study is the first quantification of lipids in human nasal fluid. Glycerophospholipids and cholesterol, as well as to a lesser extent triglycerides and free fatty acids, have already been described in bronchioalveolar and nasal lavages, whereby the lipids were mainly thought to originate from lung surfactant reaching the upper airways through mucociliary propulsion (35, 36, 37). However, the ...
Fig. 6. Nasal carriers of S. aureus are deficient in antimicrobial components that are restored by the addition of noncarrier secretions. (A) S. aureus, isolated from donor 24, was used as the target bacterium in a CFU microassay of nasal fluid from two noncarriers (donors 4 and 11) and two carriers (donors 20 and 24, gamma-irradiated fluid). While the noncarriers fluids were bacteriostatic or bactericidal, the carriers fluids did not inhibit bacterial growth. (B) The 1:1 mix of nasal secretions from an S. aureus carrier (donor 24) with fluid from a noncarrier (donor 4) is bactericidal to indigenous flora, while the mix of nasal secretions from an S. aureus carrier with heat-inactivated (boiling for 10 min) secretions from a noncarrier promoted the growth of indigenous bacteria. ...
Resp. 030 Nasal Epithelium 100X Price includes a one time usage. You will get immediate access to the file and for 30 days after purchase.
Save 28% Natural Care - SinuFix Nasal Mist Super Strength 0.5 Ounces SinuFix Nasal Mist Super Strength For Adults & Children Nasal Decongestant Mist Homeopathic Non-Addictive Works Quickly Year-Round Relief Non-Prescription No Chemical Dependency No Preservatives No Side Effects Indications This product is designed and formulated for the temporary, soothing relief of nasal and sinus congestion and pressure, and dry, irritated nasal membranes associated with a cold and sinusitis; irritated/swollen sinus passages; hay fever; or other upper respiratory allergies (allergic rhinitis).* Helps cleanse nasal passages and promotes nasal and sinus drainage. 90% of Germs, Viruses and Pollutants May Enter Your Body Through the Nose! All of us breath in through our nose and are inundated daily with thousands of foreign microparticles. Super Strength SinuFix Mist is an innovative formula specifically designed to assist with nasal congestion. Homeopathic Ingredient / *Possible Symptoms Addressed Ambroisia
List of 8 disease causes of Nasal allergies, patient stories, diagnostic guides, drug side effect causes. Diagnostic checklist, medical tests, doctor questions, and related signs or symptoms for Nasal allergies.
In vitro proteolytic cleavage of human IgA1. Human sIgA and human nasal secretions were proteolytically cleaved with recombinant IgA protease from N. gonorrhoeae. The digestion occurred in reaction buffer (50 mM Tris, 100 mM NaCl, 1 mM EDTA, pH 7.5) for 20 hours at 37°C with an enzyme/protein ratio of 1:50 (wt/wt). Cleavage of IgA was confirmed by Western blot and anti-human IgA conjugated to alkaline phosphatase.. Human nasal secretion-binding assay. Adherence of different pneumococcal strains to human nasal fluid (hNF) was assessed in a solid-phase binding assay as previously described (13, 69). To generate homogeneous samples, hNF samples were sonicated for 1 second with an amplitude of 10. In brief, nasal mucus or protease-treated mucus (10 μg/well) was immobilized in PBS in a 96-well flat-bottom plate (Sarstedt) followed by centrifugation at 250 g for 3 minutes and incubation overnight at 37°C. The plates were gently washed 3 times with DMEM medium, and the wells were blocked with 0.1% ...
The mucosa, or mucous membrane, is a type of tissue that lines the nasal cavity. Mucous membranes are usually moist tissues that are bathed by secretions such as in the nose ...
Buying bulk-size Tissue boxes? Dreading those late summer fall flowers pollens? Acute Nasal Balance your solution taken every minutes needed until your symptoms subside Acute Nasal Balance also works great with acute responses other foods Restores your body balance after exposed nasal discharge dust animals plants mold Contains Acidum Sulfuricum Renalis Mold Combo Nasal Mucosa Platelet Activating Factor Esch Cali
These cells in the nose may serve as the virus entry point, according to an analysis of a single-cell RNA sequencing dataset spanning multiple tissue types.
The respiratory tract is divided into the upper respiratory tract (extrathoracic airway passages above the neck) and lower respiratory track (airway passages and lung parenchyma below the pharynx) (Figure 15-1). The upper respiratory track reaches from the nostril or mouth to the pharynx and functions to conduct, heat, humidify, filter, and chemosense incoming air. Leaving the nasal passage, air is warmed to about 33°C and humidified to about 98% water saturation. Air is filtered in the nasal passages with highly water-soluble gases being absorbed efficiently. The nasal passages also filter particles, which may be deposited by impaction or diffusion on the nasal mucosa. ...
The respiratory tract is divided into the upper respiratory tract (extrathoracic airway passages above the neck) and lower respiratory track (airway passages and lung parenchyma below the pharynx) (Figure 15-1). The upper respiratory track reaches from the nostril or mouth to the pharynx and functions to conduct, heat, humidify, filter, and chemosense incoming air. Leaving the nasal passage, air is warmed to about 33°C and humidified to about 98% water saturation. Air is filtered in the nasal passages with highly water-soluble gases being absorbed efficiently. The nasal passages also filter particles, which may be deposited by impaction or diffusion on the nasal mucosa. ...
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In: 5th L.H. Gray Trust Workshop, The single cell microgel assay (COMET), technical aspects and applications, Sutton, England 1994. London : Inst. of Cancer Res. 1994 ...
Post nasal drip - What can cause post nasal drip into air passage in thoat and what can I do to stop it. Post nasal drip. Hello. The nasal mucus could be excessive especially during allergy season. I would recommend first a nasal saline wash. Sometimes just removing the pollen from the lining inside your nose is effective. Another option would be an OTC antihistamine like Zyrtec, Allegra or Claritin. Each is available an generic too. Good luck.
This research protocol involves one or more of the following procedures in healthy volunteers and patients with known or suspected predisposition to respiratory infection who are enrolled in National Institutes of Health (NIH) protocols: 1) Adults only: bronchoscopy with sampling of bronchoalveolar lavage fluid and epithelial cells in healthy adult volunteers and patients; 2) Adults and Children: sputum induction for collection of sputum specimens; 3) Adults and Children: nasal mucosal biopsies and brushings for sampling of epithelial cells; 4) Adults and Children: measurement of nasal nitric oxide production; 5) Adults and children: collection of exhaled breath condensate; 6) Adults and children: measurement of nasal potential difference. The cellular and acellular samples will be separated, and stored or transferred to the appropriate laboratories investigating these diseases.. Alveolar macrophages are the predominant (greater than 95%) cell type present in the lavage of normal subjects. ...
This research protocol involves one or more of the following procedures in healthy volunteers and patients with known or suspected predisposition to respiratory infection who are enrolled in National Institutes of Health (NIH) protocols: 1) Adults only: bronchoscopy with sampling of bronchoalveolar lavage fluid and epithelial cells in healthy adult volunteers and patients; 2) Adults and Children: sputum induction for collection of sputum specimens; 3) Adults and Children: nasal mucosal biopsies and brushings for sampling of epithelial cells; 4) Adults and Children: measurement of nasal nitric oxide production; 5) Adults and children: collection of exhaled breath condensate; 6) Adults and children: measurement of nasal potential difference. The cellular and acellular samples will be separated, and stored or transferred to the appropriate laboratories investigating these diseases.. Alveolar macrophages are the predominant (greater than 95%) cell type present in the lavage of normal subjects. ...
Desde 1981, o uso da pressão aérea positiva através do CPAP nasal vem sendo considerado o principal tratamento clínico da síndrome da apnéia-hipopnéia obstrutiva do sono (SAHOS), apesar de sua adesão parcial a longo prazo. Alguns autores referem que as queixas nasais provenientes do fluxo de ar sob pressão positiva na cavidade nasal são as principais responsáveis pela interrupção do tratamento. Isto ocorreria porque o uso do CPAP levaria a alterações na mucosa e mudanças no transporte mucociliar e, conseqüentemente, um maior número de infecções nasosinusais. OBJETIVO: Avaliar o clearance mucociliar nasal em pacientes com SAHOS em uso de CPAP nasal através do teste de sacarina e correlacionar os efeitos adversos desta terapia com o tempo de tratamento e o nível de pressão utilizada no mesmo. FORMA DE ESTUDO: Estudo clínico caso-controle. MATERIAL E MÉTODO: Foram avaliados 25 pacientes com SAHOS entre 18 a 70 anos em uso de CPAP nasal a partir de um mês acompanhados no ...
The method described in this study enables the culture of CF and control nasal epithelial cells. Since the harvesting of the cells is without marked trauma or stress to the patient or volunteer, it enables easy comparison of cells from patients with different CF mutations as well as the inclusion of age- and sex-matched control subjects. We believe that this method may help to investigate some of the challenging problems associated with the bioelectrical function of CF epithelium and the relationship to infection and inflammation.. This is not the first report to use nasal brushings as a source for epithelial cells. Noncultured brushings have been used to determine ciliary beat frequency (39) for the assessment of cell populations (4) and the determination of CFTR location and function (13, 20). Lopez-Souza et al. (28) described novel methods to establish three-dimensional cultures obtained by scraping the nose with a curette and subsequent electrophysiological investigations. However, these ...
Triamcinolone is used to prevent and treat seasonal and year-round allergy symptoms (such as stuffy/runny nose, itchy eyes/nose/throat, sneezing).
I am a strep carrier and have chronic swollen nasal passages that are most likely the result of lifelong allergies. Even though strep carriers are not supposed to become more ill than others, I alway...
Virtually all parents ask me why their new baby makes so much noise while breathing. The answer is simple: The noise is in the nose. Everyone, including newborns, produces nasal secretions. You and I unconsciously clear them by coughing or swallowing. But Lucy doesnt bother to clear her passages unless the accumulation is causing her serious breathing trouble. Also, her nasal passages are so narrow that a tiny bit of obstruction produces a tremendous amount of noise. The result is rumbling, grunting, and other monstrous sounds that seem wholly out of keeping with her delicate and cute appearance. This rumble is amplified by the silence of the night.. Nasal secretions do not indicate a cold, allergy, or discomfort. They are normal products of an infants respiratory system, and theres no need to try to fix them by changing the sleeping position, using nose drops, or, worst of all, wielding a nasal aspirator [See: Nasal Aspirator]. Nor will a humidifier reduce the noise. When she feels like it, ...
Did you experience any recurrence of the bloody nasal discharge and presence of other symptoms? The nasal mucosa is very vascular and minor or infrequent
Covid-19: Intracellular observation of reconstituted human respiratory epithelium MucilAir ™ infected with SARS-CoV-2. © Manuel Rosa-Calatrava, Inserm; Olivier Terrier, CNRS; Andrés Pizzorno, Signia Therapeutics; Elisabeth … Read more. ...
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The prevalence of asthma and rhinitis two major form of allergies was one and 10 percent likewise in 1964 in the country but new data shows that about 14 per cent people now have asthma, while over 20 per cent are pain from allergic rhinitis (AR) which results from an IgE-mediated inflammation of the nasal mucosa ...
Nasalate cream is designed for post -operative care of nasal mucosa and as an aid in the treatment of nasal vestbulitisFor more information www.carepharma.com.au
... s affect domestic cats via nasal mucosa. Oral ingestion has no effects. They induce noticeable behavioral effects ...
For nasal mucosa, sinuses, bronchi, and lungs. This group includes: Flunisolide Fluticasone furoate Fluticasone propionate ... A variety of steroid medications, from anti-allergy nasal sprays (Nasonex, Flonase) to topical skin creams, to eye drops ( ... Allergic rhinitis Atopic dermatitis Hives Angioedema Anaphylaxis Food allergies Drug allergies Nasal polyps Hypersensitivity ...
The drug was also astringent on nasal mucosa. In man, an oral dose of 50 mg produced no effects on blood pressure. Later ...
Bende M, Löth S (March 1986). "Vascular effects of topical oxymetazoline on human nasal mucosa". The Journal of Laryngology and ... It can reduce nasal airway resistance (NAR) up to 35.7% and reduce nasal mucosal blood flow up to 50%. Imidazolines are ... Some of these commercials showed men, women, and children using other brands of nasal sprays, and then standing upside down on ... Vasoconstriction of vessels results in relief of nasal congestion in two ways: first, it increases the diameter of the airway ...
Adhesions and synachiae between septal mucosa and lateral nasal wall. Saddle nose due to over-resection of the dorsal wall of ... the nasal septum being the partition between the two nasal cavities. Ideally, the septum should run down the center of the nose ... Deviated nasal septum or "crooked" internal nose can occur at childbirth or as the result of an injury or other trauma. If the ... The nasal tissues should mostly stabilize within 3-6 months post-surgery, although shifting is still possible for up to and ...
The eponym "Schneiderian membrane" is another name for the nasal mucosa. Liber de osse cribriformi, 1655. De catarrhis, 1660. ... In 1660-62 he published "De catarrhis", a multi-volume work in which he refuted the long-held belief that nasal mucus was a ...
"Acanthamoeba from human nasal mucosa infected with an obligate intracellular parasite". European Journal of Protistology. 30 (1 ... Using a nasal swab from volunteers, they were able to isolate coccoid-shaped bacteria that were present among other naturally- ...
They may cause pressure necrosis of the nasal septum or lateral wall of nose. Rhinoliths can cause nasal obstruction, epistaxis ... Nosebleed and pain may occur due to the ulceration of surrounding mucosa.[citation needed] They are removed under general ... A rhinolith is a stone present in the nasal cavity. The word is derived from the roots rhino- and -lith, literally meaning " ... They can be diagnosed from the history with unilateral foul-smelling blood-stained nasal discharge or by anterior rhinoscopy. ...
Adult flukes mate in a nasal mucosa of anatid birds (e.g. Anas platyrhynchos, Spatula clypeata or Cairina moschata) and produce ... adults laying eggs in the nasal mucosa (only in avian hosts). Although mice are accidental hosts, most of the studies dealing ... In avian hosts, T. regenti reaches the nasal tissue where it mates and lay eggs. The gross pathology at this site consists of ... Neither the presence of worms has been detected in a nasal cavity nor has their maturation been noticed in the nervous tissue. ...
... rex favours the mucosae of mouth, nose and throat in humans. Other leeches that also settle in mucosae have been ... When Tyrannobdella rex inhabits the nasal cavity it can cause strong headaches. Because of its small size the leech is most ... The finding of Tyrannobdella rex and genetic comparisons of its genome to other leeches that infest the mucosae of mammals has ... mucosae) of its host and feed on their blood. In contrast to other leeches, T. rex does not drop off its host after feeding but ...
April 2005). "Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis". Journal of Immunology. 174 (8 ... with normal IgE levels in their blood-recent research has shown that IgE production can occur locally in the nasal mucosa. IgE ...
The nasal congestion is due to dilation of vessels in the nasal mucosa.[medical citation needed] Prazosin is an α1-blocker that ...
The nasal mucosa also traps particles preventing their entry further into the tract. In the rest of the respiratory tract, ... In the upper part of the respiratory tract the nasal hair in the nostrils traps large particles, and the sneeze reflex may also ... This movement towards the pharynx is either upward from the lower respiratory tract or downwards from the nasal structures ...
... umbellulone will diffuse from the nasal mucosa into the blood circulation. Because of the high lipid solubility of umbellulone ... Exposure to umbellularia is likely to result in an intense cold sensation in the nasal cavity. When combined with a headache, ...
... the nasal mucosa came into contact with infectious material. Karunarathnae proposed that the satellite lesions in skin and ... This organism infects the mucosa of the nasal cavity, producing a mass-like lesion. This mass appears to be polypoidal in ... This mass may extend from the nasal cavity into the nasopharynx and present itself in the oral cavity. These lesions commonly ... List of parasites (human) Alexis Berrocal & Alfonso López (March 2007), "Nasal rhinosporidiosis in a mule", Can Vet J, 48 (3): ...
The virus replicates in the surface cells of the nasal mucosa, tonsils, and pharynx. Low body temperature allows the virus to ... CHV is transmitted to puppies in the birth canal and by contact with infected oral and nasal secretions from the mother or ...
... is located on the lateral wall of the nasal cavity below the posterior end of the inferior nasal concha ( ... turbinate). The plexus is of large thin-walled veins which lie in a thin mucosa. A nosebleed (epistaxis) usually occurs in the ... The plexus is located below the posterior end of the inferior concha, on the lateral wall of the nasal cavity. He described it ... Posterior nasal packing is needed for posterior epistaxis. Woodruff, GH (November 1949). "Cardiovascular epistaxis and the naso ...
Photophobia (light intolerance). Dryness of other mucosae, e.g., nasal, laryngeal, and/or genital. Burning sensation. Itching ... Mucosa that appears dry. A lack of saliva pooling in the floor of the mouth during examination. Dysphagia - difficulty ... Lozenges are soft and gentle on the mouth and there is a belief that prolonged contact with the oral mucosa mechanically ... These are viscous products which are applied to the oral mucosa, which can be found in the form of sprays, gels, oils, ...
The septal nasal cartilage, (cartilage of the septum or quadrangular cartilage) is composed of hyaline cartilage.[1] It is ... Septal nasal cartilage. Bones and cartilages of septum of nose. Right side (cartilage of the septum visible as blue structure ... Its anterior margin, thickest above, is connected with the nasal bones, and is continuous with the anterior margins of the ... Anatomy figure: 33:02-01 at Human Anatomy Online, SUNY Downstate Medical Center - "Diagram of skeleton of medial (septal) nasal ...
A nasal meatus is a nasal passage of the nasal cavity, of which there are three; the superior meatus, middle meatus and ... The nasal meatuses are located beneath each of the corresponding nasal conchae. In the case where a fourth, supreme nasal ... It lies below the inferior concha and above the nasal cavity. It extends most of the length of the nasal cavity's lateral wall ... These nasal meatuses are also known as meatus nasi superior, meatus nasi medius, and meatus nasi inferior. (A meatus is a ...
Eggs exit the host in nasal secretion or, if swallowed, with feces. When swallowed by an intermediate host, the four-legged ... Adult L. serrata embed their forebody into the nasopharyngeal mucosa, feeding on blood and fluids. Females live at least two ...
Pheromone Olfaction Grüneberg, H (1973). "A ganglion probably belonging to the N. terminalis system in the nasal mucosa of the ... The Grueneberg ganglion (GG), also written as Grüneberg ganglion is an olfactory subsystem located at the entrance of the nasal ...
It also supplies parasympathetic innervation to the nasal mucosa and the lacrimal gland via the pterygopalatine ganglion. The ... also mucosa of nasal cavity. Axons of type SVE, special visceral efferent, innervate muscles of facial expression, stapedius, ... It also provides parasympathetic innervation to the sphenoid sinus, frontal sinus, maxillary sinus, ethmoid sinus, and nasal ... including the nasal glands, the palatine glands, the lacrimal gland, and the pharyngeal gland. ...
Nasal polyps are polypoidal masses arising mainly from the mucous membranes of the nose and paranasal sinuses. They are ... overgrowths of the mucosa that frequently accompany allergic rhinitis. They are freely movable and nontender.[citation needed] ... The name is of ancient origin, in use in English from about 1400 for a nasal polyp, from Latin polypus through Greek. The ...
Nasal and oral mucosa bleeds. *Gastrointestinal bleeding. *Excessive/spontaneous bleeding or bruising from minor injury ...
The color and texture of the vomer mucosa matches the nasal mucosa much better than the oral mucosa. Sometimes, patients are ... and similarity between the vomer tissue and the nasal mucosa. A major disadvantage of the vomer flap surgery is the varying ... This procedure can be used to reconstruct the nasal or oral surfaces by either raising the vomer or creating a flap. Surgical ... The vomer is a triangle shaped bone that forms the inferior and posterior portion of the nasal septum (www.emedicine.com/ ...
The optimal temperature for rhinovirus replication is 33-35 °C, which corresponds to the temperature of nasal mucosa. At 37 °C ... This may be the major reason why rhinoviruses can replicate better in the nasal passages and upper tracheobronchial tree than ... Although an increase in polymorphonuclear neutrophils are shown in infected nasal epithelium, little or no mucosal damage ... pneumoniae infection may destroy respiratory mucosal cells and facilitate the penetration of antigens into the mucosa. A study ...
The larvae then make their way up the nasal passage in the mucosa and enter a nasal sinus. During this time it will develop, ... When the larva is fully developed it moves down the nasal passage and drops to the ground where it buries itself and pupates. ... Once the larvae have infested the nasal passage and sinuses, usually up to 15 larvae but can be up to 80, they cause irritation ... This can in some cases lead to malnutrition and death Sometimes mature larvae are unable to escape from the nasal sinus and die ...
"Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats". ... retro-nasal olfaction). Inside the nasal cavity, mucus lining the walls of the cavity dissolves odor molecules. Mucus also ... These agents not only damage the olfactory epithelium, but they are likely to enter the brain via the olfactory mucosa. Trauma- ... CHEN, M; LANDER, T; MURPHY, C (May 2006). "Nasal health in Down syndrome: A cross-sectional study". Otolaryngology-Head and ...
N. fowleri invades the central nervous system via the nose, specifically through the olfactory mucosa of the nasal tissues. ... "Safe Ritual Nasal Rinsing" (PDF). Centers for Disease Control and Prevention. Retrieved 28 September 2020. Marciano-Cabral, F; ... bathing or nasal irrigation. The amoeba follows the olfactory nerve fibers through the cribriform plate of the ethmoid bone ...
... s are due to the rupture of a blood vessel within the richly perfused nasal mucosa. Rupture may be spontaneous or ... There are two types of nasal packing, anterior nasal packing and posterior nasal packing.[12] There are a number of different ... Spontaneous epistaxis is more common in the elderly as the nasal mucosa (lining) becomes dry and thin and blood pressure tends ... Application of a topical antibiotic ointment to the nasal mucosa has been shown to be an effective treatment for recurrent ...
... colds are defined as upper respiratory tract infections that affect the predominantly nasal part of the respiratory mucosa,via ... 2 using a nasal gel) showed that the zinc treatment had a beneficial effect and 7 (5 using zinc lozenges, 1 using a nasal spray ... nasal sprays, and nasal gels on the common cold [69]. Of the 14 randomized, placebo-controlled studies included, 7 (5 using ... Nasal decongestants for the common cold,url=,journal=Cochrane Database Syst Rev,language=en,volume=,issue=1,page=CD001953,pages ...
Areas normally affected are lips, buccal mucosa, gingivae, frenum and tongue. The most common injuries are lips and gingivae. ... Nasal fracture. *Le Fort fracture of skull. *Zygomaticomaxillary complex fracture. *Zygoma fracture ... The facial nerve and parotid duct should be examined for any potential damage when the buccal mucosa is involved. ... Facial nerve should be examined for any potential damage when buccal mucosa is involved. ...
Treatment measures for localised GPA of the nose and sinuses includes nasal irrigation, nasal corticosteroids, and antibiotics ... non-specific ulcerations throughout oral mucosa[14] ... Nasal or oral inflammation: *painful or painless oral ulcers or ... Typical signs and symptoms include nosebleeds, stuffy nose and crustiness of nasal secretions, and inflammation of the uveal ... Mendenhall WM, Olivier KR, Lynch JW, Mendenhall NP (April 2006). "Lethal midline granuloma-nasal natural killer/T-cell lymphoma ...
Within its mucosa are millions of embedded gastric glands. Their secretions are vital to the functioning of the organ. ... The roof of the mouth is termed the palate and it separates the oral cavity from the nasal cavity. The palate is hard at the ... Most of the oral cavity is lined with oral mucosa, a mucous membrane that produces a lubricating mucus, of which only a small ... It is the part of the throat immediately behind the nasal cavity at the back of the mouth and above the esophagus and larynx. ...
"Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis". J. Immunol. 174 (8): 5024-32. doi:10.4049/ ... with normal IgE levels in their blood-recent research has shown that IgE production can occur locally in the nasal mucosa.[20] ...
Due to the formation of diptheroid plaques on the eyelids and the mucosae of the respiratory system and gastrointestinal system ... Symptoms in individual birds include loss of appetite, decreased egg production (nearing 20-40% decreases), nasal discharge, ...
... it is characterized by the release of a vapor whose sharp and penetrating odor strongly irritates the nasal mucosa and ...
swelling of the nasal mucosa ಮೂಗಿನ ಹೊರಳೆಯಲ್ಲಿನ ಲೊಳೆ ಸುರಿಸುವ ಭಾಗದ ಊತ,ಅಲರ್ಜಿಕ್ ಗುರುಳೆಗಳು ...
Once inhaled, variola major virus invaded the oropharyngeal (mouth and throat) or the respiratory mucosa, migrated to regional ... Transmission occurred through inhalation of airborne Variola virus, usually droplets expressed from the oral, nasal, or ... pharyngeal mucosa of an infected person. It was transmitted from one person to another primarily through prolonged face-to-face ...
... receptor since they mediate vasoconstriction and constricting nasal vasculature causes decongestion of nasal mucosa. This ... For their nasal delivery system, see inhaler.. A decongestant, or nasal decongestant, is a type of pharmaceutical drug that is ... Nasal spray. References[edit]. *^ Robert D. Ficalora (28 May 2013). Mayo Clinic Internal Medicine Board Review. Oxford ... Topical nasal or ophthalmic decongestants quickly develop tachyphylaxis (a rapid decrease in the response to a drug after ...
2003). „Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa.". Clin. Exp. Allergy. 32 (7 ...
Nasal polyp. Rhinorrhea. nasal septum Nasal septum deviation. Nasal septum perforation. Nasal septal hematoma. tonsil. ... "High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa". International Journal of Oral Science ... Extranodal NK/T-cell lymphoma, nasal type. MCPyV Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic ...
The skull consists of five major bones: the frontal (top of head), parietal (back of head), premaxillary and nasal (top beak), ... The digestion products are then absorbed through the intestinal mucosa into the blood. The intestine ends via the large ... and filtered in the nasal passages and upper parts of the trachea.[30] From there, the air enters the lower trachea and ...
2003). "Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa". Clin. Exp. Allergy. 32 (7 ...
Irritants of the nasal mucosa. Light. Cold air. Sanitation. Infection. ਢੰਗ. Expulsion of air through nose/mouth. ... The function of sneezing is to expel mucus containing irritants from the nasal cavity. ...
Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa. „J Allergy Clin Immunol". 121 (6), s ...
"Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats". ... retro-nasal olfaction).[2] Inside the nasal cavity, mucus lining the walls of the cavity dissolves odor molecules. Mucus also ... CHEN, M; LANDER, T; MURPHY, C (May 2006). "Nasal health in Down syndrome: A cross-sectional study". Otolaryngology - Head and ... The peripheral olfactory system consists mainly of the nostrils, ethmoid bone, nasal cavity, and the olfactory epithelium ( ...
নাসাগহ্বর (Nasal cavity). *নাসাগলবিল (Nasopharynx). *স্বরযন্ত্র (Larynx). *অধোশ্বাসপথ (Lower respiratory tract). *শ্বাসনালী ( ... Gastric mucosa *Muscularis mucosa. *Gastric rugae. *Gastric pits. *Gastric gland. *Cardiac glands ...
If the substance reaches the nasal mucosa via the tear duct, it can be absorbed into the bloodstream and cause systemic side ...
... oral mucosa, some of the salivary glands and the skin of his face (from below the eyelids to the neck and from ear to ear). The ... the nasal structure, the nose, the lips, the muscles of facial movement used for expression, the nerves that provide sensation ... teeth and nasal cavity, and was since then unable to eat. She had undergone around 35 reconstructive plastic surgery operations ...
Lateral wall of nasal cavity; the three nasal conchæ have been removed. ... The posterior group (sometimes the posterior ethmoidal sinus) drains into the superior meatus above the middle nasal concha; ... They lie between the upper parts of the nasal cavities and the orbits, and are separated from these cavities by thin bony ...
FWS is characterized mainly by skeletal abnormalities, which include nasal hypoplasia, a depressed or narrowed nasal bridge, ... This increased risk is due to the anti-platelet effect of NSAIDs as well as the possible damage to the gastrointestinal mucosa. ...
Murphy, P (July 1967). "A fibre-optic endoscope used for nasal intubation". Anaesthesia. 22 (3): 489-91. doi:10.1111/j.1365- ... topical application of local anesthetics to the mucosa, rectal anesthesia, or intravenous anesthesia. While otherwise effective ...
Nasal conchae/meatus: Superior nasal concha · Middle nasal concha · Inferior nasal concha · Superior nasal meatus · Middle ... nasal meatus · Inferior nasal meatus. Sphenoethmoidal recess · Ethmoid bulla · Agger nasi · Ethmoidal infundibulum · Semilunar ...
Oxíxeno nasal de fluxo alto Para SpO2 ,93%. Pode impedir a necesidade de intubación e ventilación ... "High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa". International Journal of Oral Science ... fluxo nasal, ou dor de garganta. Tamén se observan en variadas porcentaxes síntomas como náuseas, vómitos e diarrea.[33][37][38 ... tamén se pode utilizar unha mostra de frotis nasal ou esputo.[20][70] Xeralmente os resultados están listos en poucas horas ou ...
For nasal mucosa, sinuses, bronchii, and lungs.[34] This group includes: *Flunisolide[35] ... from anti-allergy nasal sprays (Nasonex, Flonase) to topical skin creams, to eye drops (Tobradex), to prednisone have been ...
The nasal mucosa lines the nasal cavity. It is part of the respiratory mucosa, the mucous membrane lining the respiratory tract ... The nasal mucosa is intimately adherent to the periosteum or perichondrium of the nasal conchae. It is continuous with the skin ... The epithelium of the nasal mucosa is of two types - respiratory epithelium, and olfactory epithelium differing according to ... It is also thick over the nasal septum where increased numbers of goblet cells produce a greater amount of nasal mucus. It is ...
... is a type of tissue that lines the nasal cavity. Mucous membranes are usually moist tissues that are bathed by secretions such ... The mucosa, or mucous membrane, is a type of tissue that lines the nasal cavity. Mucous membranes are usually moist tissues ...
Im aware that some substances can be absorbed through the mucus membranes inside of the nostrils and nasal cavities. Does ... I am aware that there are companies that make CBD nasal sprays (strangely enough) as well as topical items, however research ... CBD Oil/Tincture through nasal mucosa?. Okay, I know that started off weird but just hang in here with me. My mother has severe ... Im aware that some substances can be absorbed through the mucus membranes inside of the nostrils and nasal cavities. Does ...
The nasal mucosa is the tissue that lines the nasal cavity, which is made up of four layers. The main purpose of the nasal ... The nasal mucosa, also known as the mucous membrane and respiratory mucosa, is the tissue that lines the nasal cavity. The ... The nasal mucosa is moist tissue that secretes mucous. This mucous lines the nasal cavity in order to catch bacteria and other ... Most people are familiar with nasal mucosa and how it helps keep out infections but few people know that we also require nasal ...
Nasal mucosa is considerably more lenient in letting molecules through than the blood-brain barrier, and so can act as a secret ... The new technique relies on nasal mucosal grafting that is normally performed after minimally invasive brain tumor procedures ...
Effects of an alpha2-adrenoceptor agonist in nasal mucosa.. [M R Corboz, L M Varty, M A Rivelli, J C Mutter, G Mingo, R McLeod ...
... Hideaki Shirasaki, Etsuko ... "Correlation of Local FOXP3-Expressing T Cells and Th1-Th2 Balance in Perennial Allergic Nasal Mucosa," International Journal of ...
The nasal mucosa cells were collected by scraping the nasal cavity with a wooden spatula that was previously moistened with ... Micronuclei in nasal mucosa, oral mucosa and lymphocytes in students exposed to formaldehyde vapor in anatomy class. Biomed ... Alteraciones en los núcleos de las células epiteliales de la mucosa nasal de los estudiantes expuestos a formaldehído ... Nasal mucosa changes in students exposed to formaldehyde vapour. Indian J of Otolaryngol Head Neck Surg. 2002; (54): 18-19. [ ...
The nasal cavity forms part of the system of airways that conducts air to and from the lungs. The walls of the conducting ... Illustration of the human nasal passage with an enlarged section showing its histology. ... Keywords: anatomy, human body, mucosa, nasal, nasal mucosal epithelium, nose, olfaction, olfactory, olfactory sense, sense, ... Caption: Illustration of the human nasal passage with an enlarged section showing its histology. The nasal cavity forms part of ...
Human nasal mucosa was acquired during routine endoscopic sinus surgery. Cells were cultivated on object slides and exposed to ... Influence of topical antifungal drugs on ciliary beat frequency of human nasal mucosa: an in vitro study.. Hofmann T1, Reinisch ... The aim of this research was to study the effects of antifungal drugs on ciliary beat frequency (CBF) of human nasal mucosa ... Case series of in vitro experiments and in vitro study of cultured ciliated cells of human nasal mucosa. ...
Inflammatory profiles in nasal mucosa of patients with persistent vs intermittent allergic rhinitis. Authors. *. F. Liu,. * ... Inflammatory profiles in nasal mucosa of patients with persistent vs intermittent allergic rhinitis. Allergy 2010; 65: 1149- ... Methods: Inferior nasal turbinate tissue was obtained from 12 PER, 12 IAR and 12 nonallergic nonrhinitic (control) patients, ... study suggest that PER is characterized by a significantly greater eosinophilic and predominantly Th2 cell-mediated nasal ...
There is 1 somewhat common condition that can cause Itchy Nasal Mucosa and Multiple Joints. ... The freeMD virtual doctor has found 1 condition that can cause Itchy Nasal Mucosa and Multiple Joints. ... Itchy Nasal Mucosa and Multiple Joints 1 Cause. The freeMD virtual doctor has found 1 condition that can cause Itchy Nasal ... There is 1 somewhat common condition that can cause Itchy Nasal Mucosa and Multiple Joints.. *Drug Side Effect ...
... in nasal mucosa of 15 atopic children and ten atopic adults.. METHODS: Explanted mucosa was cultured with allergen with or ... Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not ... Lipopolysaccharide inhibits allergic inflammation in nasal mucosa of atopic children by skewing local immune responses from Th2 ... and four times in expression of interleukin 10 compared with mucosa stimulated with allergen alone. This difference in response ...
Occupational exposure to formaldehyde and histopathological changes in the nasal mucosa. Message subject: (Your Name) has ...
Is it possible and does it make sense to apply C60 to nasal mucosa? I have issues with nose dryness and minor crust (few year ... C60 for nasal mucosa - posted in C60Oil: Hello, ... C60 for nasal mucosa. Started by Redbulloid , Mar 07 2019 07:53 ... Is it possible and does it make sense to apply C60 to nasal mucosa? I have issues with nose dryness and minor crust (few year ... Oil should stay on mucosa for some time and then moved away by epithelium. ...
In vitro nasal mucosa gland-like structure formation on a chip K. Na, M. Lee, H. Shin and S. Chung, Lab Chip, 2017, 17, 1578 ... The aim of this study was to produce an in vitro human nasal mucosa model for reliable drug screening and clinical applications ... Morphological and functional similarities between in vivo nasal mucosa and our model indicated its utilization as a reliable ... Furthermore, our in vitro nasal mucosa presented different appearance and characteristics under hypoxic conditions. ...
A Safety Study to Compare the Effect of Two PrEP-001 Nasal Powder Formulations on Nasal Mucosa and Serum Cytokine Production. ... A Safety Study to Compare the Effect of Two PrEP-001 Nasal Powder Formulations on Nasal Mucosa and Serum Cytokine Production ... Randomised Study to Compare the Effect of Two PrEP-001 Nasal Powder Formulations on Nasal Mucosa and Serum Cytokine Production ... Any finding in the medical history review, physical examination (including nasal exam with nasal speculae), screening ...
Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose. ... Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose ( ...
1. Phospholipase A2 expression in the human nasal mucosa. Open this publication in new window or tab ,,Phospholipase A2 ... 2. Phospholipase A2 expression in the human nasal mucosa. Open this publication in new window or tab ,,Phospholipase A2 ... Expression of members of the phospholipase A2 family of enzymes in human nasal mucosa. Lindbom, John Linköping University, ... The relative abundances of the different PLA2 transcripts in normal human nasal mucosa were found to be X ≈ IVA , IIA ≈ IIE ≈ ...
ICD-10-PCS code 090K4KZ for Alteration of Nasal Mucosa and Soft Tissue with Nonautologous Tissue Substitute, Percutaneous ...
ICOS-Expressing CD4 T Cells Induced via TLR4 in the Nasal Mucosa Are Capable of Inhibiting Experimental Allergic Asthma. Karim ... ICOS-Expressing CD4 T Cells Induced via TLR4 in the Nasal Mucosa Are Capable of Inhibiting Experimental Allergic Asthma ... ICOS-Expressing CD4 T Cells Induced via TLR4 in the Nasal Mucosa Are Capable of Inhibiting Experimental Allergic Asthma ... ICOS-Expressing CD4 T Cells Induced via TLR4 in the Nasal Mucosa Are Capable of Inhibiting Experimental Allergic Asthma ...
Inhibitory Effect of Lactobacillus gasseri TMC0356 and Lactobacillus GG on Enhanced Vascular Permeability of Nasal Mucosa in ... TMC0356 might alleviate nasal allergic symptoms by suppressing the increase in nasal vascular permeability caused by local ... The nasal vascular permeability of ovablumin (OVA)-sensitized Brown Norway rats was evaluated by analyzing a brilliant blue ... Oral administration of ,I,Lactobacillus,/I, GG and ,I,L. gasseri,/I, TMC0356 significantly inhibited the increase in nasal ...
Targeted Disruption of the Olfactory Mucosa-Specific Cyp2g1 Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, ... Targeted Disruption of the Olfactory Mucosa-Specific Cyp2g1 Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, ... Targeted Disruption of the Olfactory Mucosa-Specific Cyp2g1 Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, ... Targeted Disruption of the Olfactory Mucosa-Specific Cyp2g1 Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, ...
In Situ Naphthalene Bioactivation and Nasal Airflow Cause Region-Specific Injury Patterns in the Nasal Mucosa of Rats Exposed ... In Situ Naphthalene Bioactivation and Nasal Airflow Cause Region-Specific Injury Patterns in the Nasal Mucosa of Rats Exposed ... In Situ Naphthalene Bioactivation and Nasal Airflow Cause Region-Specific Injury Patterns in the Nasal Mucosa of Rats Exposed ... In Situ Naphthalene Bioactivation and Nasal Airflow Cause Region-Specific Injury Patterns in the Nasal Mucosa of Rats Exposed ...
... on nasal mucosa radiation damage both in vivo and in vitro. ... on nasal mucosa radiation damage both in vivo and in vitro. ... Cytokines Conditioned medium Mesenchymal stem cells Nasal mucosa Radiation damage This is a preview of subscription content, ... Duan HG, Ji F, Zheng CQ, Wang CH, Li J (2014) Human umbilical cord mesenchymal stem cells alleviate nasal mucosa radiation ... Conditioned medium from umbilical cord mesenchymal stem cells improves nasal mucosa damage by radiation. ...
Nasal Mucosa,Medical Illustration database of the best portfolios and stock images now features General and Commercial ... Sagittal section of dog head showing nasal cavity structures including the nasal mucosa, conchae, sinuses, pharynx, larynx, ... ... Fractured (Broken) Nose - Reconstruction Surgery of Nasal Bone Fractures with Osteotomy and Realignment of the Nasal Septum. # ... Nasal Polyp Surgery series - 11 full color airbrush illustrations of The Anterior Ethmoidal Approach to the Frontal Nasal Sin ...
Naegleria fowleri immunization modifies lymphocytes and APC of nasal mucosa. by Physicians Weekly , Dec 17, 2017 , 0 comments ... antibody that we previously found interacting with trophozoites in the nasal lumen avoiding the N. fowleri attachment to nasal ... nasal passages (NP) and spleen (SP). In all immunized groups, the percentage of CD4 was higher than CD8 cells. CD45 was ...
Endobronchial and nasal mucosa biopsies were obtained from 5 patients with clinically-stable, diagnosed asthma (ATS criteria). ... Increases in HLA-DR expression were also seen in the nasal mucosa biopsies from asthmatics although the increases over normal ... T cell dominated inflammatory reactions in the bronchioles of asymptomatic asthmatics are also present in the nasal mucosa. ... T cell dominated inflammatory reactions in the bronchioles of asymptomatic asthmatics are also present in the nasal mucosa. ...
Effect of mitomycin-C on contraction and migration of human nasal mucosa fibroblasts: implications in dacryocystorhinostomy ... Effect of mitomycin-C on contraction and migration of human nasal mucosa fibroblasts: implications in dacryocystorhinostomy ... Aim To determine the effect of mitomycin-C (MMC) on the contraction and migration of human nasal mucosal fibroblasts (HNMFs) in ... Methods Primary cultures of HNMFs were established from nasal mucosal tissues of patients undergoing DCR. Myofibroblast ...
... project duration. 01- ... The project describes histomorphologically and biochemically the healing process in human respiratory mucosa after sinus ... proliferation of epithelium and extracellular matrix and remodeling interact in the mucosa during healing. ...
  • The nasal mucosa lines the nasal cavity. (wikipedia.org)
  • The mucosa, or mucous membrane, is a type of tissue that lines the nasal cavity. (medlineplus.gov)
  • The nasal mucosa , also known as the mucous membrane and respiratory mucosa, is the tissue that lines the nasal cavity . (wisegeek.com)
  • This mucous lines the nasal cavity in order to catch bacteria and other materials that enter the nose. (wisegeek.com)
  • The nasal cavity is particularly susceptible to infection and other problems because of its exposure to the environment. (wisegeek.com)
  • The mucous produced within the nasal cavity is different and of a thinner consistency than the mucous in the ear. (wisegeek.com)
  • The bottom layer of the nasal cavity tissue, under the basement membrane, is the lamina propria, which is filled with blood vessels and seromucosal glands. (wisegeek.com)
  • Cilia are small, hair-like fibers that line the nasal cavity walls and protect the tissue from infection. (wisegeek.com)
  • Another way the nasal cavity lining prepares air to enter the respiratory system is by warming it with the heat radiating from the blood vessels within the lamina propria. (wisegeek.com)
  • Rhinitis is a general term that describes any condition that results in infected and irritated nasal cavity lining. (wisegeek.com)
  • The nasal cavity forms part of the system of airways that conducts air to and from the lungs. (sciencephoto.com)
  • The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. (uchicago.edu)
  • with the exception of the olfactory mucusa, it includes the entire nasal cavity. (thefreedictionary.com)
  • What are two functions of the mucosa found in the nasal cavity? (reference.com)
  • The mucosa, or mucus membrane, that can be found in the nasal cavity is highly vascular, helping to warm and moisten incoming air and is important for smel. (reference.com)
  • It lies below the inferior concha and above the nasal cavity. (wikipedia.org)
  • A cationic lipid emulsion was formulated with soybean oil and 1,2-dioleoyl-sn-glycero-3-trimethylammonium-propane (DOTAP) as major components and was used to transfer genes to the epithelial cells of the mouse nasal cavity via intranasal instillation. (elsevier.com)
  • The transfection activities of the lipid carriers in nasal cavity mucosae are in agreement with the stability of the lipid carriers and their complexes with DNA. (elsevier.com)
  • The epithelium of the nasal mucosa is of two types - respiratory epithelium, and olfactory epithelium differing according to its functions. (wikipedia.org)
  • CYP2G1 is a cytochrome P450 monooxygenase expressed uniquely in the olfactory mucosa (OM). (aspetjournals.org)
  • Severe cellular injury occurred exclusively in the olfactory mucosa 24 h postinhalation exposure to 3.4 ppm NA for 4 h. (aspetjournals.org)
  • Injury within the olfactory mucosa from inhaled NA was confined to the medial meatus, whereas systemic NA generated severe injury throughout the olfactory region. (aspetjournals.org)
  • The pattern of nasal injury from inhaled NA in this study is consistent with previous studies of nasal airflow simulation within the olfactory region. (aspetjournals.org)
  • The nonolfactory mucosa on the nasal septum, a high airflow region, metabolized naphthalene slowly, whereas the olfactory regions of the nasal septum and ethmoturbinates metabolized this substrate at high rates. (aspetjournals.org)
  • This study concludes that 1) the incidence of acute nasal injury from systemic and inhaled NA correlates with the rates of regional microsomal NA metabolism and that 2) the nasal airflow pattern determines the pattern of olfactory mucosal injury from inhaled NA. (aspetjournals.org)
  • The mammalian nasal passage is lined with four different epithelial populations: squamous, transitional (nonciliated cuboidal/columnar), respiratory, and olfactory epithelium. (aspetjournals.org)
  • Among these, the olfactory mucosa (i.e., the olfactory epithelium and its underlying lamina propria) contains four primary cells: the duct cells lining Bowman's glands, basal cells, olfactory receptor cells, and the sustentacular cells or olfactory supporting cells. (aspetjournals.org)
  • Therefore, the olfactory mucosa has the potential to metabolize protoxicants that require in situ bioactivation. (aspetjournals.org)
  • For a number of species, including nonhuman primates, nasal tissue, especially olfactory mucosa, contains high concentrations of P450s. (aspetjournals.org)
  • The development of the respiratory and olfactory mucosae from the old world monkey, Macaca nemestrina, from fetal (F) 121 days to postnatal (P) 9.5 years, has been examined by light and electron microscopy. (uwindsor.ca)
  • By F121 days, respiratory and olfactory mucosae appeared to be morphologically capable to carry out their required functions. (uwindsor.ca)
  • Changes in smell acuity induced by radiation exposure of the olfactory mucosa. (biomedsearch.com)
  • The effects of ionizing radiation on smell acuity were assessed in 12 patients in whom the olfactory mucosa was exposed to radiation in the course of treatment for nasopharyngeal carcinoma or pituitary adenoma. (biomedsearch.com)
  • Although severe infltration of eosinophil in the respiratory mucosa were seen, there was little infltration in olfactory mucosa. (nii.ac.jp)
  • There was little distribution of amphiregutin in the olfactory mucosa compared with that in the respiratory mucosa. (nii.ac.jp)
  • Therefore, the effect of the olfactory mucosa due to the respiratory mucosal remodeling was indicated that the possibility of dysfunction of the olfactory mucosa was due to the secretory change. (nii.ac.jp)
  • The present work was aimed to study the diffusion potential of different generations of Poly (propyleneimine) (PPI) dendrimers on goat nasal mucosa in an ex vivo study and synthesize a stable dendrimer for olfactory drug delivery. (innovareacademics.in)
  • It is part of the respiratory mucosa, the mucous membrane lining the respiratory tract. (wikipedia.org)
  • It is continuous with the skin through the nostrils, and with the mucous membrane of the nasal part of the pharynx through the choanae. (wikipedia.org)
  • The mucous membrane is thickest, and most vascular, over the nasal conchae. (wikipedia.org)
  • The nasal mucosa is moist tissue that secretes mucous. (wisegeek.com)
  • The mucous produced by the nasal mucosa is the body's answer to the vulnerability of exposed internal tissue. (wisegeek.com)
  • The first layer within the nasal mucosa, under the mucous lining, is the pseudostratified columnar epithelium. (wisegeek.com)
  • The mucous within the nasal mucosa not only serves to remove bacteria from the air entering the respiratory system, but it also humidifies, or adds moisture, to the air. (wisegeek.com)
  • Even with the protective lining of mucous, the nasal mucosa remains quite susceptible to infection and inflammation . (wisegeek.com)
  • Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells. (uchicago.edu)
  • Introduction The main histological features of the nasal mucosa in choanal atresia are distorted cilia, marked increase of mucous submucosal glands associated with marked reduction of goblet cell density, and lymphocytic cellular infiltration. (arquivosdeorl.org.br)
  • It is also thick over the nasal septum where increased numbers of goblet cells produce a greater amount of nasal mucus. (wikipedia.org)
  • Fractured (Broken) Nose - Reconstruction Surgery of Nasal Bone Fractures with Osteotomy and Realignment of the Nasal Septum. (indexedvisuals.com)
  • The pronounced edema of the nasal mucosa and persistent congestion disturb in chronic polyposis, adenoiditis, curved nasal septum. (medhelpsis.com)
  • Gross mucosal edema of the septum and turbinates was the main finding on nasal examination. (elsevier.com)
  • The septal nasal cartilage , ( cartilage of the septum or quadrangular cartilage ) is composed of hyaline cartilage . (wikipedia.org)
  • Moreover, the ELISA dosage of SIgA in nasal secretion, sampled by cotton swabs positioned between septum and middle turbinate for 20 minutes every 4 hours 5 times in a day, can be easily performed and shows significant differences between the healthy child and the healthy adult. (biomedcentral.com)
  • Nasal secretions could be sampled by the insertion between the middle turbinate and the septum of swabs of cotton which are removed after 20 minutes and immediately squeezed out. (biomedcentral.com)
  • Computed tomography of the paranasal sinuses showed only mucosal hypertrophy with a possible soft tissue mass in the inferior part of the nasal septum but no evidence of bony destruction. (bmj.com)
  • An examination under anaesthetic showed no discrete mass but a biopsy of the nasal septum revealed inflammatory cells, macrophages, and mature B and T lymphocytes. (bmj.com)
  • This is why when we have a stuffy nose or other issues with our nasal membrane or mucus, we are not able to smell as well. (wisegeek.com)
  • Moreover, this investigation demonstrates, for the first time, the presence of the newly discovered phospholipase A 2 forms IID, IIE, III, IVB, IVC, X and calcium-independent membrane bound phospholipase A 2 in the human nasal mucosa and raises the possibility that one or several of these may be involved in inflammatory reactions in the nose. (diva-portal.org)
  • The nasal vascular permeability of ovablumin (OVA)-sensitized Brown Norway rats was evaluated by analyzing a brilliant blue concentration in perfusate from the nose after exposure of the nasal mucus to OVA. (nii.ac.jp)
  • We investigated if intranasal immunization with amoebic lysates plus cholera toxin modified the populations of T and B lymphocytes, macrophages and dendritic cells by flow cytometry from nose-associated lymphoid tissue (NALT), cervical lymph nodes (CN), nasal passages (NP) and spleen (SP). (physiciansweekly.com)
  • ICD-10-PCS code 09JKXZZ for Inspection of Nasal Mucosa and Soft Tissue, External Approach is a medical classification as listed by WHO under the range -Ear, Nose, Sinus. (aapc.com)
  • The causes of edema are different, but most often the swelling of the mucosa in the nose appears with a cold and allergic rhinitis. (medhelpsis.com)
  • Nasal congestion always appears during ARVI, when the nose is flowing snot, as well as at the end of the common cold, and is a herald of inflammation of the paranasal sinuses. (medhelpsis.com)
  • If the above drugs do not help within 1-2 weeks, nasal glucocorticoids can be sprayed into the nose - Rinocort, Sintaris, Nasobek, etc. (medhelpsis.com)
  • 10 documented a release of inflammatory mediators in nasal-wash fluids when compressed cold and dry air was delivered through the nose. (ersjournals.com)
  • On examination his nose was red and swollen (see fig 1) with granular mucosa in the left nasal vestibule. (bmj.com)
  • Liu F, Zhang J, Liu Y, Zhang N, Holtappels G, Lin P, Liu S, Bachert C. Inflammatory profiles in nasal mucosa of patients with persistent vs intermittent allergic rhinitis. (wiley.com)
  • Morphological and functional similarities between in vivo nasal mucosa and our model indicated its utilization as a reliable research model for nasal diseases including allergic rhinitis, chronic sinusitis, and nasal polyposis. (rsc.org)
  • This medical exhibit contrasts normal nasal passage anatomy with allergic rhinitis in a series of four illustrations. (indexedvisuals.com)
  • In subjects with allergic rhinitis, allergen challenge led to parallel increases in eosinophil counts, levels of EPX and eotaxin concentrations in nasal lavage fluid. (nii.ac.jp)
  • These results indicate that eotaxin has an important role in eosinophil-dependent inflammation in nasal mucosa and suggest that blocking eotaxin or CCR-3 might be useful for new therapeutic tools of allergic rhinitis. (nii.ac.jp)
  • To gain a better understanding of the role of TARC in the pathogenesis of allergic rhinitis, we have investigated the cellular sources of this chemokine in nasal mucosa. (nii.ac.jp)
  • Epithelial cells in nasal mucosa in subjects with allergic rhinitis expressed higher signal level than those in non-allergy patients. (nii.ac.jp)
  • Microvascular remodeling of nasal mucosa in allergic rhinitis induced by an allergen in Sprague-Dawley rats. (semanticscholar.org)
  • Glucocorticoids are currently the most potent medication available for the treatment of nasal polyposis and allergic rhinitis, but exact mechanisms and cellular targets in the nasal mucosa are uncertain. (kjorl.org)
  • Gene and protein expression of protease-activated receptor 2 in structural and inflammatory cells in the nasal mucosa in seasonal allergic rhinitis. (ox.ac.uk)
  • Here, the present study aimed to explore the expression of PAR 2 in the nasal mucosa of seasonal allergic rhinitis (SAR). (ox.ac.uk)
  • Topical intranasal corticosteroids are currently used as the first line of treatment for rhinitis because they reduce the inflammation of the mucosa that underlies the signs and symptoms of the disease . (bvsalud.org)
  • Inferior turbinates were obtained from patients suffering from either allergic or nonallergic rhinitis during corrective nasal surgery. (elsevier.com)
  • Conclusions: Our findings suggest that decreasing sympathetic innervation may have a role in the pathophysiology of rhinitis and may be particularly significant in relation to glandular functions in allergic nasal mucosa. (elsevier.com)
  • Wang, HW & Chu, YH 2005, ' Noradrenergic nerve fluorescence in the nasal mucosa of rhinitis patients ', Journal of Medical Sciences (Taiwan) , vol. 25, no. 4, pp. 185-189. (elsevier.com)
  • the same pattern of expression was found in perennial rhinitis (B) and nasal polyps (C) (hematoxylin, original magnification ×400). (jamanetwork.com)
  • Nasal obstruction is a crucial symptom in allergic rhinitis and it is primarily a vascular phenomenon caused by distension of the sinusoids with blood[ 10 ]. (biomedcentral.com)
  • The factors involved in the development of chronic inflammation and edema in nasal polyps remain to be clarified. (semanticscholar.org)
  • The expression of vascular endothelial growth factor (VEGF) has been described in plasma cells, suggesting that plasma cells may play a major role in the development of edema in nasal polyps through the production of VEGF. (semanticscholar.org)
  • Inflammatory cells as well as epithelial cells in nasal polyps express vascular endothelial growth factor. (semanticscholar.org)
  • Will I ever get rid of my nasal polyps? (enthelp.com)
  • Expression of Glucocorticoid Receptor in Nasal Polyps and Nasal Mucosa. (kjorl.org)
  • Multifactorial effects of glucocorticoid are initiated by their binding to a specific cytoplasmic glucocorticoid receptor (GR). We performed this study to investigate the localization and distribution ot' human 4R and GR j3 isoform in nasal mucosa and to examine the influence of allergy and eosinophilic infiltration on GR and GR betaisoform expression in nasal polyps. (kjorl.org)
  • Nasal polyps (NP), middle turbinate mucosa (MT) and inferior turbinate (IT) mucosa were taken from 40 patients with chronic sinusitis and nasal polyps. (kjorl.org)
  • Nasal polyps drip im sure. (medhelp.org)
  • We examined the effect of bacterial lipopolysaccharide on allergic inflammation and expression of cytokines and lipopolysaccharide receptor (toll-like receptor 4 TLR4) in nasal mucosa of 15 atopic children and ten atopic adults. (nih.gov)
  • Lipopolysaccharide inhibits allergic inflammation in nasal mucosa of atopic children by skewing local immune responses from Th2 to Th1 and upregulating production of interleukin 10. (nih.gov)
  • The precise roles of the different PLA 2 enzymes in airways inflammation are not known and the gene expression of the different PLA 2 s in the human nasal mucosa has not previously been examined. (diva-portal.org)
  • TMC0356 might alleviate nasal allergic symptoms by suppressing the increase in nasal vascular permeability caused by local inflammation associated with allergic rhnititis. (nii.ac.jp)
  • It is concluded that inflammation present in the nasal mucosa of asymptomatic asthmatics exhibits cellular characteristics also seen in endobronchial biopsies. (bmj.com)
  • To evaluate the role of eotaxin in eosinophilic inflammation in nasal mucosa, we investigated the levels of eosinophil chemoattractants in nasal lavage fluids obtained after antigen challenge, and compared with eosinophil counts and eosinophil protein X (EPX) levels. (nii.ac.jp)
  • With inflammation of the nasal mucosa or the effects of irritants, its vessels become inflamed and expand. (medhelpsis.com)
  • With allergies the mucosa has a pale shade, with infectious inflammation it is red. (medhelpsis.com)
  • Nasal brushing has sometimes been used to characterize some affections of the respiratory tract, but seldom employed in chronic diseases such as asthma, for the possible presence of cellular inflammation in the small specimens used for electron microscopy. (univr.it)
  • In conclusion, nasal obstruction of OSA patients on CPAP treatment is inflammatory in origin and the addition of heated humidification decreases nasal resistance and mucosal inflammation. (ersjournals.com)
  • 11 showed that CPAP employed in rats can trigger early nasal inflammation. (ersjournals.com)
  • Our hypothesis was that nasal side effects of CPAP are inflammatory in origin and the addition of heated humidification attenuates nasal mucosal inflammation and decreases the elevated nasal resistance caused by the use of CPAP. (ersjournals.com)
  • Propolis decreased inflammation and enhanced healing of wounds of the nasal mucosa in rats. (propolisscience.org)
  • It is very thin in the meatuses on the floor of the nasal cavities, and in the various sinuses. (wikipedia.org)
  • I'm aware that some substances can be absorbed through the mucus membranes inside of the nostrils and nasal cavities. (yahoo.com)
  • The other 2 patients, after 18 and 23 months of achieving a patent choana, showed normal nasal cavities. (arquivosdeorl.org.br)
  • [1] It is somewhat quadrilateral in form, thicker at its margins than at its center, and completes the separation between the nasal cavities in front. (wikipedia.org)
  • Most people are familiar with nasal mucosa and how it helps keep out infections but few people know that we also require nasal mucus for our sense of smell. (wisegeek.com)
  • Mucus is the carrier in which the tiny particles reach these receptors in the nasal membrane, which then communicate with the brain to tell us what we are smelling. (wisegeek.com)
  • ENT doctor examining nasal passages in special mirrors sees swollen mucus, discharge. (medhelpsis.com)
  • Moreover, PAR 2 mRNA expression in epithelial cells (SAR: 4.78+/-4.64 vs. controls: 0.84+/-0.61, P=0.003) but not in mucus (SAR: 1.51+/-1.15 vs. controls: 1.35+/-1.02, P=0.78) and endothelial cells (SAR: 1.20+/-0.57 vs. controls: 1.73+/-1.30, P=0.5) was found to be significantly changed in the nasal mucosa in SAR. (ox.ac.uk)
  • Occupational exposure to formaldehyde and histopathological changes in the nasal mucosa. (bmj.com)
  • The article distinguishes three groups of causes for symptoms of nasal congestion/obstruction, which are mucosal causes, structural causes and sensory causes. (oatd.org)
  • 20 patients with OSA on nasal CPAP who exhibited symptomatic nasal obstruction were randomised to receive either 3 weeks of CPAP treatment with heated humidification or 3 weeks of CPAP treatment with sham-heated humidification, followed by 3 weeks of the opposite treatment, respectively. (ersjournals.com)
  • Nasal obstruction and nasal discharge taken together were reported by 62.5% of patients. (elsevier.com)
  • Infiltration of the lamina propria by inflammatory cells in nasal polyposis. (jamanetwork.com)
  • Methods Primary cultures of HNMFs were established from nasal mucosal tissues of patients undergoing DCR. (bmj.com)
  • These results suggest that aerosolization of soluble antigen formulations with CT may provide an alternative method of delivering nasal vaccines to sheep and other large animal species, and that further improvements in antigen penetration of nasal tissues may dramatically improve the strength of the immune response. (edu.au)
  • Using immunohistochemistry, laser-assisted cell picking and subsequently real-time PCR, nasal mucosa biopsies of SAR patients were investigated for PAR 2 gene and protein expression in complex tissues of the nasal mucosa. (ox.ac.uk)
  • The relative gene expression level of PAR 2 was significantly increased in complex tissues of the nasal mucosa of SAR (6.21+/-4.02 vs. controls: 1.38+/-0.86, P=0.004). (ox.ac.uk)
  • The conjunctiva, part of the eye mucosa, has immunologic features in common with other mucosal tissues. (jimmunol.org)
  • abstract = "Background: It is generally accepted that the parasympathetic nerve predominates in patients with nasal allergies. (elsevier.com)
  • abstract = "Purpose: The inhalation of nasal snuff (powdered tobacco) is a common addiction in the Indian subcontinent. (elsevier.com)
  • Human nasal mucosa was acquired during routine endoscopic sinus surgery. (nih.gov)
  • The project describes histomorphologically and biochemically the healing process in human respiratory mucosa after sinus surgery and searches for modulating factors. (ugent.be)
  • Nasal nitric oxide concentration in paranasal sinus inflammatory diseases. (semanticscholar.org)
  • Five Cases of IgG4-related Disease with Nasal Mucosa and Sinus Involvement. (illumina.com)
  • Nasal respiratory function grows up gradually in childhood together with nasal and sinus anatomical structure and immunological defences. (biomedcentral.com)
  • Normal subjects had few, if any, eosinophils and EPX as well as the measured parameters in their nasal lavage fluids before and after antigen challenge. (nii.ac.jp)
  • In addition, … More treatment of eosinophils with anti CCR3 mAb significantly blocked eosinophil TEM induced by homogenate of nasal mucosa. (nii.ac.jp)
  • Epithelial cells may be an important site of action for intranasal steroids, and the increased number of eosinophils infiltrating the mucosa and allergy did not amplify the number of immunostaining of GK and GR beta isoform. (kjorl.org)
  • Using double immunohistochemistry the present study demonstrated that the total numbers of mast cells (P=0.0003) and eosinophils (P=0.03) and the numbers of eosinophils expressing PAR 2 (P=0.006) were significantly elevated in the nasal mucosa of SAR compared with the controls. (ox.ac.uk)
  • CONCLUSION: The abundant presence and distribution of gene and protein expression of PAR 2 in different cell types in the nasal mucosa under normal situation, the increased expression of PAR 2 in epithelial cells and the increased number of eosinophils with PAR 2 suggest that PAR 2 may contribute to the pathogenesis of allergic diseases such as SAR. (ox.ac.uk)
  • Although either the amount of DP or the amount of CRTH2 was not correlated with serum levels of IgE, the amount of CRTH2 but not DP was highly and significantly correlated with the number of eosinophils infiltrating into nasal musosa. (elsevier.com)
  • Influence of topical antifungal drugs on ciliary beat frequency of human nasal mucosa: an in vitro study. (nih.gov)
  • The aim of this research was to study the effects of antifungal drugs on ciliary beat frequency (CBF) of human nasal mucosa under in vitro conditions. (nih.gov)
  • Case series of in vitro experiments and in vitro study of cultured ciliated cells of human nasal mucosa. (nih.gov)
  • However, to date, few studies have reported the development of a complicated in vitro human nasal epithelial model. (rsc.org)
  • The aim of this study was to produce an in vitro human nasal mucosa model for reliable drug screening and clinical applications. (rsc.org)
  • Here, we integrated and optimized several culture conditions such as cell type, airway culture conditions, and hydrogel scaffolds into a microfluidic chip to construct an advanced in vitro human nasal mucosa model. (rsc.org)
  • Furthermore, our in vitro nasal mucosa presented different appearance and characteristics under hypoxic conditions. (rsc.org)
  • To explore therapeutic effects of conditioned medium from human umbilical cord mesenchymal stem cells (hUC-MSCs) on nasal mucosa radiation damage both in vivo and in vitro. (springer.com)
  • Shao D, Massoud E, Clarke D, Cowley E, Renton K, Agu RU (2013) Optimization of human nasal epithelium primary culture conditions for optimal proton oligopeptide and organic cation transporters expression in vitro. (springer.com)
  • Aim To determine the effect of mitomycin-C (MMC) on the contraction and migration of human nasal mucosal fibroblasts (HNMFs) in vitro in order to identify the least concentration of MMC required to prevent cicatrix development following dacryocystorhinostomy (DCR). (bmj.com)
  • The drug increased resting tension in human nasal mucosa in vitro through direct actions and potentiated mucosal contractions by norepinephrine and epinephrine. (elsevier.com)
  • Endobronchial and nasal mucosa biopsies were obtained from 5 patients with clinically-stable, diagnosed asthma (ATS criteria). (bmj.com)
  • The distribution of immunocompetent cells within the nasal biopsies of the asthmatic patients reflected a very similar inflammatory infiltrate to that seen in the bronchial biopsies. (bmj.com)
  • Significantly raised numbers of T lymphocytes, CD45RO + lymphocytes, RFD1 + macrophage-like cells and RFD7 + macrophages were seen in both the nasal mucosa and the bronchial biopsies. (bmj.com)
  • Increases in HLA-DR expression were also seen in the nasal mucosa biopsies from asthmatics although the increases over normal did not reach statistical significance. (bmj.com)
  • Results Four biopsies (4 repaired choanal atresia sides) of the mucosa of the inferior turbinate revealed that 1 patient (who had a bilateral choanal atresia repaired), after achieving a patent choana for 8 months, had not completely recovered a normal nasal mucosa. (arquivosdeorl.org.br)
  • Nasal turbinate biopsies were taken from house dust mite allergic patients, before and after nasal allergen provocation. (biomedcentral.com)
  • The epithelium of the normal nasal mucosa shows intense annexin A1 staining in the ciliated cells, especially within the cilia. (jamanetwork.com)
  • Of the variety of methods used to treat nasal symptoms during CPAP treatment, the most common is heated humidification of the inspired air 13 . (ersjournals.com)
  • We aimed to investigate whether exposure to this compound was correlated with the appearance of cytotoxic and genotoxic features in the nasal epithelial cells of students enrolled in a human anatomy course. (isciii.es)
  • This prospective study collected periodically nasal cells from mucosa of 17 volunteers from two different undergraduate programs with different workloads of practical lessons in an anatomy laboratory, 30 and 90 hours per semester. (isciii.es)
  • Anatomy figure: 33:02-01 at Human Anatomy Online, SUNY Downstate Medical Center - "Diagram of skeleton of medial (septal) nasal wall. (wikipedia.org)
  • The nasal mucosa is characterized by a complex micro vascular anatomy. (biomedcentral.com)
  • Given that vascular endothelium form a gateway for inflammatory cells into the local mucosa, one possible explanation is that during endothelial transmigration the pro-inflammatory characteristics of cells entering the mucosa are dampened through the local exposure to endothelial IL-10. (biomedcentral.com)
  • Lastly, the influx of inflammatory cells and mediators of the early and the late inflammatory phase from blood to the local tissue contributes to nasal blockage, rhinorrhoea, sneezing, and pruritus[ 11 ]. (biomedcentral.com)
  • We observed that the inducing factors for nasal gland-like structures were secreted from activated human dermal microvascular endothelial cells. (rsc.org)
  • In our experiments of eosinophil endothelial transmigration (TEM) assay using the nasal microvascular endothelial cells, eotaxin showed most potent effect among various eosinophil chemoattractants. (nii.ac.jp)
  • Interleukin-10 (IL-10) is a negative regulator of immune responses and was previously shown to be expressed by human nasal endothelial cells, while the adhesion molecule MECA-79 plays a role in trans-endothelial migration of immune competent cells. (biomedcentral.com)
  • We previously found expression of Interleukin-10 (IL-10) on the endothelial cells in the nasal mucosa of allergic subjects. (biomedcentral.com)
  • Furthermore, by opening the gaps in the intercellular junctions between the endothelial cells, extravasation of plasma takes places, which ultimately contributes to rhinorrhoea formation and swelling of the nasal mucosa. (biomedcentral.com)
  • Four men had perforated nasal septa and 2 others to have some degree of septal ulceration. (cdc.gov)
  • As evidence of this, are the five individuals in whom injected nasal mucosa were noted and the 2 men with active septal ulceration. (cdc.gov)
  • It has been shown that interactions between CCR4 and MDC/CCL22 and TARC/CCL17, as well as between CCR8 and I-309/CCL1, are critical for the recruitment of Th2 cells in the airway mucosa of allergic diseases in response to allergen stimulation. (nii.ac.jp)
  • Nasal continuous positive airway pressure (CPAP) can cause undesirable nasal symptoms, such as congestion to obstructive sleep apnoea (OSA) patients, whose symptoms can be attenuated by the addition of heated humidification. (ersjournals.com)
  • Nasal continuous positive airway pressure (CPAP) is considered the standard of care for treating moderate-to-severe obstructive sleep apnoea (OSA) 1 . (ersjournals.com)
  • Indeed, deliberate mouth leaks while normal subjects were using CPAP can cause high unidirectional nasal airflow with increased nasal airway resistance 8 as well as enhance nasal mucosal blood flux 9 . (ersjournals.com)
  • In children there is no significant difference in IgG, IgA and IgE in nasal secretion between healthy subjects and those with recurrent upper airway infection, and only albumin values increase during infection [ 6 ]. (biomedcentral.com)
  • Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adults. (nih.gov)
  • A greater amount of bacterial IgA1 protease causes a confined impairment of the nasal mucosal immune barrier and may be a primary event in the pathogenesis of inflammatory respiratory disease [ 5 ]. (biomedcentral.com)
  • Most of the bacterial and fungal causes are rare and usually affect other parts of the body as well as the nasal passages. (bmj.com)
  • A total of 11 bacterial isolates from the nasal specimens were cultured. (edu.pl)
  • The nasal mucosa is intimately adherent to the periosteum or perichondrium of the nasal conchae. (wikipedia.org)
  • The nasal meatuses are located beneath each of the corresponding nasal conchae . (wikipedia.org)
  • Mechanical trauma to the nasal mucosa increases the risk of synechia formation, especially after chronic rhinosinusitis and nasal surgeries. (propolisscience.org)
  • Berger GKattan ABernheim JOphir D Polypoid mucosa with eosinophilia and glandular hyperplasia in chronic sinusitis: a histopathological and immunohistochemical study. (jamanetwork.com)
  • In humans, significant expression/activity of P450s in the nasal mucosa have been reported. (aspetjournals.org)
  • however, it is not known whether DCBN causes similar nasal toxicity in humans. (elsevier.com)
  • Thus, our data indicate for the first time that the human nasal mucosa is capable of bioactivating DCBN and that GS-DCBN and its metabolites in nasal-wash fluid may collectively serve as indicators of DCBN exposure and potential nasal toxicity in humans. (elsevier.com)
  • Hideaki Shirasaki, Etsuko Kanaizumi, Nobuhiko Seki, and Tetsuo Himi, "Correlation of Local FOXP3-Expressing T Cells and Th1-Th2 Balance in Perennial Allergic Nasal Mucosa," International Journal of Otolaryngology , vol. 2011, Article ID 259867, 6 pages, 2011. (hindawi.com)
  • However, we found that noradrenergic fluorescent fibers were significantly decreased in the glandular region of the allergic nasal mucosa. (elsevier.com)
  • Swelling of the nasal mucosa is manifested by difficulty in nasal breathing, congestion, nasal congestion and night snoring. (medhelpsis.com)
  • Among the side effects caused by CPAP, undesirable nasal symptoms such as congestion, dryness or rhinorrhea are particularly prevalent and can significantly compromise compliance 7 . (ersjournals.com)
  • Illustration of the human nasal passage with an enlarged section showing its histology. (sciencephoto.com)
  • However, the precise contribution of different PLA 2 types to the formation of inflammatory lipid mediators in the upper airways is not known and the expression of different PLA 2 genes in the human nasal mucosa has not been examined. (diva-portal.org)
  • These findings demonstrate that a large number of PLA 2 types are expressed in the normal human nasal mucosa. (diva-portal.org)
  • Despite the fact that naphthalene (NA), a volatile, ubiquitous air pollutant, was recently identified as a probable human carcinogen, little is known about nasal cytotoxicity from inhaled NA. (aspetjournals.org)
  • Duan HG, Ji F, Zheng CQ, Wang CH, Li J (2014) Human umbilical cord mesenchymal stem cells alleviate nasal mucosa radiation damage in a guinea pig model. (springer.com)
  • Expression of C-C chemokine TARC in human nasal mucosa and its regulation by cytokines'Clin Exp Allergy. (nii.ac.jp)
  • The effects of cocaine on the contractile response of isolated human nasal mucosal blood vessels to field stimulation and methoxamine were investigated. (elsevier.com)
  • The development of nasal mucosa in the non-human primate, Macaca nemes" by Cheryl. (uwindsor.ca)
  • The development of nasal mucosa in the non-human primate, Macaca nemestrina: Qualitative and quantitative analysis. (uwindsor.ca)
  • We evaluated the effects of urban air pollutants on human nasal mucosa over an 8-month period on 102 subjects living in Florence, Tuscany, Italy. (uniss.it)
  • We sought to determine the expression of synthases and receptors for PGD2 in human nasal mucosa. (elsevier.com)
  • Lindahl MSvartz JTagesson C Demonstration of different forms of the anti-inflammatory proteins lipocortin-1 and Clara cell protein-16 in human nasal and bronchoalveolar lavage fluids. (jamanetwork.com)
  • Within our research into immune regulatory processes in the nasal mucosa, we have been focusing on structural cells in the human nasal mucosa. (biomedcentral.com)
  • The human orthologues of CYP2A5, CYP2A6 and CYP2A13, are both expressed in nasal mucosa and are capable of activating DCBN. (elsevier.com)
  • In this study, we directly determined the ability of human nasal mucosa to bioactivate DCBN. (elsevier.com)
  • We found that human fetal nasal mucosa microsomes catalyze the formation of GS-DCBN, with a K m value comparable to that of adult mouse nasal mucosa microsomes. (elsevier.com)
  • The activity of the human nasal mucosa microsomes was inhibited by 8-methoxypsoralen, a known CYP2A inhibitor. (elsevier.com)
  • Several mechanisms may be potentially involved in the development of nasal discomfort with CPAP but they have been described only in healthy volunteers 8 - 10 and in a rodent model 11 . (ersjournals.com)
  • Inferior nasal turbinate tissue was obtained from 12 PER, 12 IAR and 12 nonallergic nonrhinitic (control) patients, and symptoms (visual analogue scales, VAS) and impairment of life was monitored. (wiley.com)
  • However, neither the nature of nasal symptoms nor the effect of heated humidification on nasal pathophysiology and pathology are convincingly known. (ersjournals.com)
  • However, it remains unknown if the same mechanisms could be responsible for the nasal side effects of CPAP in OSA patients, who frequently have increased nasal symptoms even in the absence of CPAP use 12 . (ersjournals.com)
  • Although several authors have studied the effect of different forms of humidification on the relative humidity of CPAP airflow, patient adherence and subjective outcomes 13 - 15 , no study has so far examined the functional pathways by which heated humidified CPAP attenuates nasal symptoms in OSA patients 16 . (ersjournals.com)
  • A randomised, crossover, sham-controlled design was adopted, and nasal resistance, nasal wash inflammatory markers and pathology of nasal mucosa were examined in OSA patients using CPAP and exhibiting nasal symptoms. (ersjournals.com)
  • At the time of the study, all patients complained of one or more nasal symptoms. (elsevier.com)
  • Explanted mucosa was cultured with allergen with or without lipopolysaccharide (0.1 mg/L) for 24 h. (nih.gov)
  • In children but not in adults, lipopolysaccharide caused increases of three times in T-cell reactivity, five times in T-cell proliferation, and four times in expression of interleukin 10 compared with mucosa stimulated with allergen alone. (nih.gov)
  • Furthermore, the amount of TARC induced by these cytokines was higher in epithelial cells obtained from nasal allergy patients than in those from non-allergy patients. (nii.ac.jp)
  • The present study evaluated the ultrastructure of epithelial cells obtained by nasal brushing in 11 allergic children with asthma, before and after staying in an environment free of allergens, usually implicated in the genesis of inflammatory events. (univr.it)
  • The proliferation and migration abilities of irradiated and non-irradiated nasal epithelial cells significantly increased after culture in bronchial epithelial cell growth medium (BEGM) containing 10% conditioned medium of hUC-MSCs compared to cells cultured in BEGM alone. (springer.com)
  • These results demonstrate a crucial role of nasal epithelial cells in the expression of TARC, and that Th2 cytokine IL-4 and IL-13 may promote Th2 responses by inducing TARC production from epithelial cells. (nii.ac.jp)
  • Nasal mucosa cells were harvested by brushing, a noninvasive procedure. (uniss.it)
  • Degenerative lesions of nasal epithelial cells were found. (meta.org)
  • The IgA secreted across the mucosa prevents microbial binding to epithelial cells in the digestive and respiratory tracts. (biomedcentral.com)
  • It exists in two forms, that differ in the structure: IgA1 is found in serum and produced by bone marrow B cells, whereas IgA2 is made by B cells located in the mucosa and has been found to be secreted into colostrum, maternal milk, tears and saliva. (biomedcentral.com)
  • To analyse potential differences in efficiency of infection and spread for different historical PRV strains, single infected cells and plaques of infected cells were quantified at 12 and 36 hpi in nasal mucosa explants for seven European PRV strains, isolated in the 1960s (Becker, NIA1), the 1970s (NS374, NIA3, 75V19) and later (89V87, 00V72). (uantwerpen.be)
  • E-cadherin immunreactivity of pseudostrafied epithelial cells of nasal mucosa was assessed by immunohistochemical staining . (bvsalud.org)
  • E-cadherin expression was significantly decreased in epithelial cells of the nasal mucosa of Nicotine group. (bvsalud.org)
  • The findings from the present study suggest that PER is characterized by a significantly greater eosinophilic and predominantly Th2 cell-mediated nasal inflammatory profile compared to IAR. (wiley.com)
  • IL-22−/− mice demonstrate significantly elevated levels of S. aureus nasal colonization as compared with wild-type (WT) mice. (tcd.ie)
  • The tissue-selective toxicity of DCBN in mouse nasal mucosa is largely dependent on target tissue bioactivation by CYP2A5. (elsevier.com)
  • Immunoexpression of vascular endothelial growth factor in gingival mucosa with papilloma and condyloma acuminata. (semanticscholar.org)
  • In order to explore this option we investigated what vascular structures could play a role in trans-migration by identifying the distribution of MECA-79, a adhesion molecule involved in transmigration, on nasal endothelium. (biomedcentral.com)
  • Studying and comparing the values and the daily variation of SIgA in nasal secretion could explain the largest number of upper respiratory infection, especially in children. (biomedcentral.com)
  • Nasal secretion SIgA mean value is lower in the healthy child than in the healthy adult. (biomedcentral.com)
  • The study of the circadian pattern variation and the values of SIgA in nasal secretion of healthy child may explain the greater number of URTI during childhood compared with adult healthy pattern. (biomedcentral.com)
  • On the contrary, in nasal secretion these variables are absent, such as the assay is more reproducible and reliable although more cumbersome to implement [ 3 ]. (biomedcentral.com)
  • Subjects must be instructed to leaning backwards the head in order to reduce any contamination with tears as any secretion from the nasolacrimal duct would run along the nasal floor. (biomedcentral.com)
  • As large Boman glands were seen and positive stain of ConA and SNA were found, the increase of mucosa secretion in the olfacoty mucosa was suspected. (nii.ac.jp)
  • An ex - vivo study was carried out on Franz Diffusion Cell with goat nasal mucosa. (innovareacademics.in)
  • We are able to smell because our nasal membrane has nerves and receptors. (wisegeek.com)
  • Different alphaherpesviruses, including pseudorabies virus (PRV), are able to cross the basement membrane barrier in nasal respiratory epithelium. (uantwerpen.be)
  • Unexpectedly, a significant reduction in the expression of the Cyp2a5 gene was found in the liver, the lateral nasal gland (LNG), and, to a lesser extent, the kidney of adult Cyp2g1 -null mice. (aspetjournals.org)
  • The superior meatus occupies the middle third of the nasal cavity's lateral wall. (wikipedia.org)
  • It extends most of the length of the nasal cavity's lateral wall. (wikipedia.org)
  • In the case where a fourth, supreme nasal concha is present, there is a fourth supreme nasal meatus . (wikipedia.org)
  • The middle meatus is the middle-sized and located nasal opening, lying underneath the middle concha and above the inferior concha where the meatus extends along its length. (wikipedia.org)
  • Intranasal administration of hUC-MSC conditioned medium effectively repairs nasal mucosa radiation damage. (springer.com)
  • Mucosa is moist tissue that lines certain parts of the inside of your body. (medlineplus.gov)
  • In microscopic views, we observed no significant difference in the distribution of noradrenergic innervation of blood vessels and epithelium between allergic and nonallergic nasal mucosa specimens. (elsevier.com)
  • Cultures of a nasal swab grew Staphylococcus aureus and oral flucloxacillin was prescribed. (bmj.com)
  • Illustration shows gastric mucosa with influx of H. Pylori (upper left) leading to peptic ulceration. (indexedvisuals.com)