Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)
A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.

The nasal airways response in normal subjects to oxymetazoline spray: randomized double-blind placebo-controlled trial. (1/93)

AIMS: The effects of a single dose of oxymetazoline nasal spray on nasal patency have been compared with placebo using three separate measuring systems in normal subjects. METHODS: The study was a placebo-controlled, randomised double-blind crossover trial. Subjects without ear, nose or throat disease and with resting nasal airways resistance >0.15 Pa s cm-3 were selected so that a fall in airways resistance could be detected. Nasal airways resistance (NAR) was measured by NR6-2 rhinomanometer. Acoustic rhinometry (SR-2000 rhinometer) provided the sum of the minimum cross-sectional areas (tMCA) and volume (tVOL) of the left and right nasal cavities. Symptoms of congestion were assessed on a visual analogue scale (CON, range 0-100). Measurements were made for 60 min before and for 120 min after bilateral administration of oxymetazoline nasal spray (0.9 mg) or placebo (0.9% saline). Crossover occurred 7-21 days later. Results for all measures were analysed as change from average baseline value by trapezoidal AUC, and statistical significance was tested by 2-way anova. RESULTS: NAR, tMCA, tVOL and CON did not change after placebo, but NAR and CON fell and tMCA and tVOL increased significantly at all timepoints after oxymetazoline. NAR_AUC, tVOL_AUC, tMCA_AUC were significantly different between placebo and oxymetazoline (P<0.001) as was CON_AUC (P=0.012). The day-to-day intraindividual repeatability of baseline NAR tMCA and tVOL was <10%. CONCLUSIONS: Normal subjects can be used to detect the effects of nasally vasoactive drugs with a variety of complementary systems, with the advantages of easy subject recruitment and low variability.  (+info)

Nasal airflow dynamics: mechanisms and responses associated with an external nasal dilator strip. (2/93)

The adhesive external nasal dilator strip (ENDS) is widely advocated for prevention of snoring and promotion of nasal breathing during exercise. In the present study, the effects of the ENDS on nasal airflow resistance (Rn) in normal subjects were examined and factors determining individual responses to the ENDS explored. Using posterior rhinomanometry, 20 healthy Caucasian adults (10 males, 10 females; age: 18-56 yrs) were studied during quiet tidal breathing and voluntary hyperpnoea with (ENDS) and without (control) ENDS and with a placebo strip (placebo) before and after application of a topical nasal decongestant (oxymetazoline hydrochloride). During tidal breathing, only nine subjects showed a significantly (p<0.05) decreased inspiratory and/or expiratory Rn with the ENDS ("responders"). During the control, inspiratory Rn (at 0.4 L x s(-1)) was higher in "responders" than "nonresponders" (3.28+/-0.16 versus 2.60+/-0.08 cmH2O x L(-1) x s; p=0.04). The effects of nasal decongestant and the ENDS were additive. During voluntary hyperpnoea, inspiratory Rn (at 1.0 L x s(-1)) and the hysteresis of the inspiratory transnasal pressure/flow curve were decreased with the ENDS in most subjects. It is concluded that the external nasal dilator strip influences nasal airflow dynamics by both dilation of the nasal valve and stabilization of the lateral nasal vestibule walls and may be more effective in subjects with a high resting nasal airflow resistance.  (+info)

Inhibition of nitric oxide synthase by nasal decongestants. (3/93)

The nasal decongestants oxymetazoline and xylometazoline are frequently used in the topical treatment of rhinitis and sinusitis. As nitric oxide (NO) is thought to play a role in inflammation of the upper respiratory tract, the aim of this study was to examine the in vitro effects of these compounds on the activity and the expression of NO producing enzymes, including the inducible form of NO synthase (iNOS) and the constitutive isoform of NO synthase (cNOS). Experiments concerning the effects of both compounds on enzymatic activity and enzyme induction of iNOS were performed in a lipopolysaccharide (LPS) induced rat alveolar macrophage cell line (NR8383) using the Griess assay and the 3H-citrulline assay respectively. The effects on cNOS were examined in fresh rat synaptosomes using the 3H-citrulline assay. The direct scavenging properties of both compounds were investigated using a amperometric NO sensor. Oxymetazoline and xylometazoline were shown to have a dose dependent inhibitory effect on total iNOS activity indicated by nitrite/nitrate formation in the Griess assay. This effect was found to be due to an inhibition of induction of the enzyme rather than inhibition of the enzyme activity, as was investigated in two separate experiments using the 3H-citrulline assay. Inhibition of cNOS was moderate and in the same order of magnitude as the inhibition of enzymatic iNOS activity. Direct scavenging of NO could not be detected. As constitutive nitric oxide synthase activity is thought to serve beneficial physiological functions, and exaggerated inducible nitric oxide synthase activity may cause exacerbation of the inflammatory process, pharmacological treatment influencing the nitric oxide generating system should focus on inhibition of inducible nitric oxide synthase alone. The specific characteristics of these decongestants in vitro suggests suitability for this application and may indicate an additional beneficial effect in the treatment of upper respiratory tract inflammation.  (+info)

Phenylpropanolamine and the risk of hemorrhagic stroke. (4/93)

BACKGROUND: Phenylpropanolamine is commonly found in appetite suppressants and cough or cold remedies. Case reports have linked the use of products containing phenylpropanolamine to hemorrhagic stroke, often after the first use of these products. To study the association, we designed a case-control study. METHODS: Men and women 18 to 49 years of age were recruited from 43 U.S. hospitals. Eligibility criteria included the occurrence of a subarachnoid or intracerebral hemorrhage within 30 days before enrollment and the absence of a previously diagnosed brain lesion. Random-digit dialing identified two matched control subjects per patient. RESULTS: There were 702 patients and 1376 control subjects. For women, the adjusted odds ratio was 16.58 (95 percent confidence interval, 1.51 to 182.21; P=0.02) for the association between the use of appetite suppressants containing phenylpropanolamine and the risk of a hemorrhagic stroke and 3.13 (95 percent confidence interval, 0.86 to 11.46; P=0.08) for the association with the first use of a product containing phenylpropanolamine. All first uses of phenylpropanolamine involved cough or cold remedies. For men and women combined, the adjusted odds ratio was 1.49 (95 percent confidence interval, 0.84 to 2.64; P=0.17) for the association between the use of a product containing phenylpropanolamine and the risk of a hemorrhagic stroke, 1.23 (95 percent confidence interval, 0.68 to 2.24; P=0.49) for the association with the use of cough or cold remedies that contained phenylpropanolamine, and 15.92 (95 percent confidence interval, 1.38 to 184.13; P=0.03) for the association with the use of appetite suppressants that contained phenylpropanolamine. An analysis in men showed no increased risk of a hemorrhagic stroke in association with the use of cough or cold remedies containing phenylpropanolamine. No men reported the use of appetite suppressants. CONCLUSIONS: The results suggest that phenylpropanolamine in appetite suppressants, and possibly in cough and cold remedies, is an independent risk factor for hemorrhagic stroke in women.  (+info)

Adult rhinosinusitis: diagnosis and management. (5/93)

Rhinosinusitis can be divided among four subtypes: acute, recurrent acute, subacute and chronic, based on patient history and a limited physical examination. In most instances, therapy is initiated based on this classification. Antibiotic therapy, supplemented by hydration and decongestants, is indicated for seven to 14 days in patients with acute, recurrent acute or subacute bacterial rhinosinusitis. For patients with chronic disease, the same treatment regimen is indicated for an additional four weeks or more, and a nasal steroid may also be prescribed if inhalant allergies are known or suspected. Nasal endoscopy and computed tomography of the sinuses are reserved for circumstances that include a failure to respond to therapy as expected, spread of infection outside the sinuses, a question of diagnosis and when surgery is being considered. Laboratory tests are infrequently necessary and are reserved for patients with suspected allergies, cystic fibrosis, immune deficiencies, mucociliary disorders and similar disease states. Findings on endoscopically guided microswab culture obtained from the middle meatus correlate 80 to 85 percent of the time with results from the more painful antral puncture technique and is performed in patients who fail to respond to the initial antibiotic selection. Surgery is indicated for extranasal spread of infection, evidence of mucocele or pyocele, fungal sinusitis or obstructive nasal polyposis, and is often performed in patients with recurrent or persistent infection not resolved by drug therapy.  (+info)

Anesthetic considerations for orthognathic surgery with evaluation of difficult intubation and technique for hypotensive anesthesia. (6/93)

Orthognathic surgery is carried out to improve facial appearance and/or to improve malocclusion. Usually, patients are young and healthy. However, they may have airway problems. Reinforced silicone low-pressure, high-volume endotracheal tubes and p-xylometazoline (Otrivin) for nasal vasoconstriction reduces problems due to the endotracheal tubes. A head-up position with ventilator and monitoring equipment at the foot end helps the surgeons as well as the surgery. Surgeons may be the cause of endotracheal tube problems. Bleeding is a major problem that may be encountered and is reduced by induced hypotension. During osteotomies, severe bradycardia may occur and may even lead to cardiac arrest. In the early postoperative period, bleeding may be a problem. Later ulceration at the tip of the nose and on the buttocks may be seen if preventive measures are not carried out.  (+info)

Comparison of the clinical efficacy of standard and mucoadhesive-based nasal decongestants. (7/93)

AIMS: To compare two xylometazoline 0.1% preparations: reference commercial solution (RS) and test mucoadhesive solution (TS). METHODS: Twenty subjects with perennial allergic rhinitis (age range 18-69 years, 5 atopic, 7 men) applied randomly in turn TS and RS for 5 days in a double-blind crossover clinical trial. Nasal airflow resistance (NAR), nasal symptoms (6 grade scoring), frequency of application (times/day), and side-effects were recorded. RESULTS: Mean ratio TS/RS of areas under the resistance/time curves for NAR +/- 90% CI: 3.56 +/- 0.92; mean TS-RS differences +/- 95% CI: for congestion: -1.12 +/- 0.59, for frequency of application: -1.10 +/- 0.20. Subjects experienced fewer side-effects with TS. CONCLUSIONS: A mucoadhesive solution with a decongestant had a greater and longer lasting effect on nasal congestion in subjects with perennial allergic rhinitis than the commercially available decongestant solution. It also caused fewer side effects.  (+info)

The stability of oxymetazoline hydrochloride in aqueous solution. (8/93)

The kinetics of the hydrolysis reaction of oxymetazoline hydrochloride in aqueous solution at three temperatures (343 K, 353 K, 363 K), over the pH-range 0.5-12.5 and ionic strength 0.5 has been investigated. The changes of concentration of oxymetazoline hydrochloride were followed by the HPLC method with UV detection. In the pH range from 0.45 to 12.50, the hydrolysis of oxymetazoline consists of hydrolysis of oxymetazoline molecules catalyzed by hydrogen ions, spontaneous hydrolysis of the dissociated and undissociated oxymetazoline molecules. A minimal rate of the hydrolysis oxymetazoline was observed to occur in the pH range from 2.0 to 5.0. Thermodynamic parameters of the reaction: energy, entropy and enthalpy of activation and the frequency factor for the specific rate constants were determined.  (+info)

Oxymetazoline is a medication that is used to treat nasal congestion and other symptoms associated with colds and allergies. It is available over-the-counter (OTC) in the form of nasal sprays, drops, and tablets. Oxymetazoline works by narrowing the blood vessels in the nasal passages, which reduces swelling and congestion. It is a sympathomimetic drug, which means that it stimulates the sympathetic nervous system to produce these effects. While oxymetazoline can be effective in relieving nasal congestion, it is important to note that it can cause rebound congestion if used for more than a few days in a row. This means that the nasal passages may become more congested after stopping use of the medication. Therefore, it is recommended to use oxymetazoline for no more than three days at a time, and to follow the instructions on the label carefully.

Rhinitis is a medical condition characterized by inflammation and swelling of the lining of the nose. It can be caused by a variety of factors, including allergies, infections, irritants, and certain medications. Symptoms of rhinitis may include a runny or stuffy nose, sneezing, congestion, postnasal drip, and facial pain or pressure. There are several types of rhinitis, including allergic rhinitis, vasomotor rhinitis, and infectious rhinitis. Treatment for rhinitis depends on the underlying cause and may include medications, lifestyle changes, and in some cases, immunotherapy.

Nasal decongestants are commonly used. It is also common practice to administer prophylactic antibiotics when the fracture ...
Nasal decongestant. Eye drops (brand names Clear Eyes, and Cleari) narrowing swollen blood vessels (ophthalmic arteries, and ... Naphazoline is a medicine used as a decongestant, and a vasoconstrictor added to eye drops to relieve red eye. It has a rapid ... Hosten LO, Snyder C (2020). "Over-the-Counter Ocular Decongestants in the United States - Mechanisms of Action and Clinical ... Extended use may cause rhinitis medicamentosa, a condition of rebound nasal congestion. Known side-effect: Stinging Discomfort ...
The safety and effectiveness of nasal decongestant use in children is unclear. Due to lack of studies, it is not known whether ... Deckx L, De Sutter AI, Guo L, Mir NA, van Driel ML (October 2016). "Nasal decongestants in monotherapy for the common cold". ... In adults short term use of nasal decongestants may have a small benefit. Antihistamines may improve symptoms in the first day ... Taverner D, Latte J (January 2007). Latte GJ (ed.). "Nasal decongestants for the common cold". The Cochrane Database of ...
Nasal decongestants may prevent sexually induced sneezing. The phenomenon was documented as early as 1897 in John Noland ... Cranial nerve zero (autonomic) is also located in the nasal cavity. Its purpose is unknown, but it is thought to play a role ( ... Sneezing occurs independent of external nasal stimuli or allergens, and may occur at any point during a sexual experience. Both ...
Table 2. Decongestants Causing Rhinitis Medicamentosa - Nasal decongestants: - Sympathomimetic: • Amphetamine "FDA Drug Safety ... drug-induced nasal congestion), reduced seizure threshold, tics (a type of movement disorder), and weight loss. Dangerous ...
Table 2. Decongestants Causing Rhinitis Medicamentosa - Nasal decongestants: - Sympathomimetic: • Amphetamine "FDA Drug Safety ... Topical nasal decongestants --(i) For products containing levmetamfetamine identified in 341.20(b)(1) when used in an inhalant ... Historically, it has been used to treat nasal congestion and depression. Amphetamine is also used as an athletic performance ... The class includes amphetamine itself, stimulants like methamphetamine, serotonergic empathogens like MDMA, and decongestants ...
... is available over-the-counter as a topical decongestant in the form of oxymetazoline hydrochloride in nasal ... It can reduce nasal airway resistance (NAR) up to 35.7% and reduce nasal mucosal blood flow up to 50%. Since imidazolines are ... Nguyen TM (2014). "Consultation submission: OTC nasal decongestant preparations for topical use: proposed advisory statements ... It is available over-the-counter as a nasal spray to treat nasal congestion and nosebleeds, as eyedrops to treat eye redness ...
Table 2. Decongestants Causing Rhinitis Medicamentosa - Nasal decongestants: - Sympathomimetic: • Amphetamine "FDA Drug Safety ... drug-induced nasal congestion), reduced seizure threshold, tics (a type of movement disorder), and weight loss. Dangerous ...
Pseudoephedrine, a nasal decongestant. Guaifenesin, an expectorant. Loperamide (Imodium AD) an anti-diarrheal agent. Pepto ... This flexible tube secures a nasal airway when the casualty does not have, or may lose their ability to keep their own airway ...
Topical decongestants are decongestants applied directly to the nasal cavity. Their effectiveness by themselves in the common ... Topical decongestants are vasoconstrictors, and work by constricting the blood vessels within the nasal cavity. Ephedrine ... Oxymetazoline Phenylephrine Propylhexedrine Pseudoephedrine Tramazoline Xylometazoline Decongestant Nasal irrigation Nasal ... "Nasal decongestants in monotherapy for the common cold". The Cochrane Database of Systematic Reviews. 10: CD009612. doi:10.1002 ...
Deckx, L; De Sutter, AI; Guo, L; Mir, NA; van Driel, ML (17 October 2016). "Nasal decongestants in monotherapy for the common ... "Zicam Cold Remedy Nasal Products (Cold Remedy Nasal Gel, Cold Remedy Nasal Swabs, and Cold Remedy Swabs, Kids Size)". U.S. Food ... Decongestants may improve nasal congestion in sinus infections. Examples are ephedrine, phenylephrine, pseudoephedrine, and ... The effectiveness of phenylephrine by mouth as a nasal decongestant is questionable. Gee's Linctus is a cough medicine which ...
Oral decongestants such as pseudoephedrine combined with an antihistamine and/or INC sprays are used in patients with nasal ... It may be used as a nasal/sinus decongestant, as a stimulant, or as a wakefulness-promoting agent in higher doses. It was first ... Deckx L, De Sutter AI, Guo L, Mir NA, van Driel ML (October 2016). "Nasal decongestants in monotherapy for the common cold". ... The safety and effectiveness of nasal decongestant use in children is unclear. Concomitant or recent (previous fourteen days) ...
Examples are nasal topical decongestants and smelling salt. Topical drug classification system (TCS) is proposed by the FDA. It ... cocaine powder used in nasal surgery). A shake lotion is a mixture that separates into two or three parts over time. Frequently ...
vasoconstriction and mydriasis; used as vasopressors, nasal decongestants and during eye exams). Selected examples are: ...
Decongestant Honeymoon rhinitis Inhaler "Nasal congestion". MedlinePlus Medical Encyclopedia. A.D.A.M., Inc. Rao A, ed. (2012 ... Nasal congestion is the partial or complete blockage of nasal passages, leading to impaired nasal breathing, usually due to ... It also recommends a number of over the counter decongestants and antihistamines. A 2012 study concluded that combining nasal ... Nasal polyps Gastroesophageal reflux disease (theorized to cause chronic rhinosinusitis- the "airway reflux paradigm") Nasal ...
Decongestant nasal sprays containing oxymetazoline may provide relief, but these medications should not be used for more than ... It is unclear if nasal irrigation, antihistamines, or decongestants work in children with acute sinusitis. There is no clear ... Rhinitis medicamentosa at eMedicine Shaikh N, Wald ER (October 2014). "Decongestants, antihistamines and nasal irrigation for ... Pain killers such as naproxen, nasal steroids, and nasal irrigation may be used to help with symptoms. Recommended initial ...
... is still sold as an oral nasal decongestant in 8 mg pills as a natural health product, with a limit of 0.4 g (400 mg ... limits and danger of ephedrine and pseudoephedrine as nasal decongestants". European Annals of Otorhinolaryngology, Head and ... It is of unclear benefit in nasal congestion. It can be taken by mouth or by injection into a muscle, vein, or just under the ... "Ephedrine Nasal Drops 1.0% Summary of Product Characteristics (SmPC)". emc. 11 March 2015. Archived from the original on 24 ...
... a stimulant commonly used as a nasal decongestant. List of sportspeople sanctioned for doping offences Yahoo! Sports " ...
... is a medication used as a decongestant for uncomplicated nasal congestion, used to dilate the pupil, used to ... Its effectiveness as a nasal decongestant has been questioned. In 2023, a Food and Drug Administration panel concluded that the ... February 2009). "A placebo-controlled study of the nasal decongestant effect of phenylephrine and pseudoephedrine in the Vienna ... "orally administered phenylephrine is effective as a nasal decongestant". The committee also unanimously believes that this does ...
"Combined effects of a mechanical nasal dilator and a topical decongestant on nasal airflow resistance". Chest. 115 (6): 1514-8 ... Fenoxazoline (trade name Aturgyl in Brazil) is a nasal decongestant. Fenmetozole has the precise same formula, albeit instead ...
... (Metron, Susat) is a nasal decongestant marketed in Japan. Octodrine Swiss Pharmaceutical Society (2000). Index ...
Pseudoephedrine is a decongestant used to relieve a nasal congestion. Benadryl Allergy Relief Plus Decongestant contains 8 mg ... Benadryl Allergy Relief Plus Decongestant can also be found in the United Kingdom. It is used to relieve sinus, stuffy and ... "Pseudoephedrine: decongestant that relieves a stuffy or blocked nose". nhs.uk. September 2, 2019. Retrieved November 2, 2020. ... chesty coughs and coughs with nasal congestion. Cough liquids for children are also available. Benadryl Chesty Forte is used to ...
... nasal decongestants, allergy shots, and alternative medicine. In the case of nasal symptoms, antihistamines are normally the ... An example of nasal decongestants is pseudoephedrine and its side-effects include insomnia, restlessness, and difficulty ... There is also nasal endoscopy, wherein a tube is inserted through the nose with a small camera to view the passageways and ... Some other nasal sprays are available by prescription, including Azelastine and Ipratropium. Some of their side-effects include ...
Decongestant nasal sprays are available over-the-counter in many countries. They work to very quickly open up nasal passages by ... Topical nasal decongestants include: Oxymetazoline Phenylephrine Xylometazoline Combination use of two medications as nasal ... Decongestant nasal sprays are advised for short-term use only, preferably 5 to 7 days at maximum. Some doctors advise to use ... Nasal sprays are used to deliver medications locally in the nasal cavities or systemically. They are used locally for ...
A decongestant, or nasal decongestant, is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper ... Decongestants are used to treat nasal congestion, for instance in allergies, infections like the common cold, influenza, and ... Topical nasal or ophthalmic decongestants quickly develop tachyphylaxis (a rapid decrease in the response to a drug after ... Decongestant nasal sprays and eye drops often contain oxymetazoline and are used for topical decongestion. Pseudoephedrine acts ...
Pretreatment for susceptible individuals can include oral and nasal decongestants, or oral and nasal steroids. Negative ... oral and nasal decongestants, or oral and nasal steroids, and appropriate pain medication if needed. Astronauts in space have ... One would be predisposed by a pre-existing upper respiratory infection, nasal allergies, recurrent changing pressures, ...
... , as a nasal decongestant, is marketed under the trade name Benzedrex. The name Benzedrex was initially ... The misuse of nasal decongestant, anorectic, and anticonvulsant preparations have all been reported. The misuse of ... Center for Drug Evaluation and Research (15 April 2021). "FDA warns that abuse and misuse of the nasal decongestant ... Inc.. Propylhexedrine is used to treat acute nasal congestion related to common cold, allergies and hay fever. For nasal ...
This might have occurred due to barotrauma of descent, and/or the effects of nasal decongestants. It is due to unequal increase ...
Topical Nasal Decongestants Most topical nasal decongestants also carry the warning against unsupervised use with hypertension ... When the nasal decongestant is taken in excess, levomethamphetamine has potential side effects. These would be similar to those ... When hypertensive patients request a nasal decongestant, the pharmacist can recommend several alternatives. Propylhexedrine (e. ... nasal decongestant inhalers in the United States. Levomethamphetamine crosses the blood-brain-barrier and acts as a ...
... (trade name Ellsyl) is a nasal decongestant against allergic and vasomotor rhinitis. Zumpft CW (January 1975). " ...
Read more about the prescription drug DECONGESTANT DROPS - NASAL. ... decongestant drops - nasal. The display and use of drug ... NASAL, includes side effects, drug interactions, recommended dosages, and storage information. ... GENERIC NAME: DECONGESTANT DROPS - NASAL Medication Uses , How To Use , Side Effects , Precautions , Drug Interactions , ... PRECAUTIONS: Before using this nasal decongestant, tell your doctor or pharmacist if you are allergic to it; or to other ...
Topical nasal decongestants, oral decongestants, nasal steroids, and antihistamines can be used to treat ETD. ... Nasal spray; may decrease number and activity of inflammatory cells, resulting in decreased nasal inflammation. Demonstrated no ... Oral decongestants. Class Summary. These agents are used to decrease swelling of eustachian tube and sinus mucosa. ... Nasal corticosteroids. Class Summary. These agents are used to decrease perieustachian tube inflammation. ...
The leading decongestant used by millions of Americans looking for relief from a stuffy nose is no better than a dummy pill, ... The FDAs nasal decongestants drug list, or monograph, has not been updated since 1995. The process for changing a monograph ... Popular nasal decongestant doesnt actually relieve congestion, FDA advisers say by: MATTHEW PERRONE, Associated Press ... FILE - Sudafed and other common nasal decongestants containing pseudoephedrine are on display behind the counter at Hospital ...
... and the good news is that there are other over-the-counter medicines that are effective as nasal decongestants, including nasal ... researchers had studies showing that as an oral decongestant, its completely ineffective. I spoke to a scientist whos been ...
... and the good news is that there are other over-the-counter medicines that are effective as nasal decongestants, including nasal ... researchers had studies showing that as an oral decongestant, its completely ineffective. I spoke to a scientist whos been ...
The FDAs nasal decongestants drug list, or monograph, has not been updated since 1995. The process for changing a monograph ... Popular nasal decongestant doesnt actually relieve congestion, FDA advisers say by: MATTHEW PERRONE, Associated Press ... FILE - Sudafed and other common nasal decongestants containing pseudoephedrine are on display behind the counter at Hospital ... FILE - Sudafed and other common nasal decongestants containing pseudoephedrine are on display behind the counter at Hospital ...
... which became the main drug in over-the-counter decongestants when medicines with an older ingredient were moved behind pharmacy ... The FDAs nasal decongestants drug list, or monograph, has not been updated since 1995. The process for changing a monograph ... Sudafed and other common nasal decongestants containing pseudoephedrine are on display behind the counter at Hospital Discount ... WASHINGTON - The leading decongestant used by millions of Americans looking for relief from a stuffy nose is no better than a ...
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE ... DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE ...
The leading decongestant used by millions of Americans looking for relief from a stuffy nose is no better than a dummy pill, ... The FDAs nasal decongestants drug list, or monograph, has not been updated since 1995. The process for changing a monograph ... Popular nasal decongestant doesnt actually relieve congestion, FDA advisers say by: MATTHEW PERRONE, Associated Press ... FILE - Sudafed and other common nasal decongestants containing pseudoephedrine are on display behind the counter at Hospital ...
The leading decongestant used by millions of Americans looking for relief from a stuffy nose is likely no better than a dummy ... The FDAs nasal decongestants drug list, or monograph, has not been updated since 1995. The process for changing a monograph ... Popular nasal decongestant in products like Dayquil doesnt actually work: FDA advisers by: Associated Press ... That would likely force consumers to switch to the behind-the-counter pills or to nasal sprays and drops that contain ...
The leading decongestant used by millions of Americans looking for relief from a stuffy nose is likely no better than a dummy ... The FDA's nasal decongestants drug list, or monograph, has not been updated since 1995. The process for changing a ... FDA advisers: Popular nasal decongestant ineffective for congestion relief. By Matthew Perrone. ... WASHINGTON (AP) - The leading decongestant used by millions of Americans looking for relief from a stuffy nose is likely no ...
The leading decongestant used by millions of Americans looking for relief from a stuffy nose is likely no better than a dummy ... The FDAs nasal decongestants drug list, or monograph, has not been updated since 1995. The process for changing a monograph ... Popular nasal decongestant in products like Dayquil doesnt actually work: FDA advisers by: Associated Press ... That would likely force consumers to switch to the behind-the-counter pills or to nasal sprays and drops that contain ...
Decongestant nasal medicationsinfluenzaNasal decongestantsOral decongestantsrunny nosevasoconstrictor decongestants ... Nasal decongestants. Medications used by the nasal route contain:. - a vasoconstrictor alone: oxymetazoline (Pernazene®, ... The term decongestant refers mainly to certain medications used to treat congestion of the nasal mucosa caused by infection or ... Nasal decongestants: how do they work?. In case of infectious rhinopharyngitis, allergic rhinitis (hay fever), or sinusitis, an ...
... which became the main drug in over-the-counter decongestants when medicines with an older ingredient were moved behind pharmacy ... The FDAs nasal decongestants drug list, or monograph, has not been updated since 1995. The process for changing a monograph ... Sudafed and other common nasal decongestants containing pseudoephedrine are on display behind the counter at Hospital Discount ... WASHINGTON - The leading decongestant used by millions of Americans looking for relief from a stuffy nose is no better than a ...
Nasal Decongestion Products by FREZYDERM for free breathing from the first application. ... NASAL DECONGESTANT. Nasal Decongestion Products by FREZYDERM for free breathing from the first application. ... Spray for cleansing and moisturizing the nasal cavity, for the relief of cold symptoms and the protection of the nasal ... Spray for cleansing and moisturizing the nasal cavity., which relieves nasal congestion and protects against sinusitis. With ...
Some reported symptoms of using nasal decongestants include nausea, vomiting, seizures, sudden onset of severe headache, ... Some reported symptoms of using nasal decongestants include nausea, vomiting, seizures, sudden onset of severe headache, ... Nasal Decongestants: Read This Before Using It Next Time. Some reported symptoms of using nasal decongestants include nausea, ... Nasal decongestants are something very common these days and are used quite often for treating cough, and cold. However, Nasal ...
Decongestants A Common Nasal Decongestant Doesnt Actually Work. What Should You Use Instead? ...
... which became the main drug in over-the-counter decongestants when medicines with an older ingredient were moved behind counters ... Popular nasal decongestant doesnt actually relieve congestion, say FDA experts. By Matthew Perrone. ... The FDA's nasal decongestants drug list, or monograph, has not been updated since 1995. The process for changing a ... The leading decongestant used by millions of Americans looking for relief from a stuffy nose is likely no better than a dummy ...
Popular nasal decongestant doesnt actually relieve congestion, FDA advisers say. pbs.org ...
The leading decongestant used by millions of Americans looking for relief from a stuffy nose is likely no better than a dummy ... Popular nasal decongestant doesnt actually relieve congestion, FDA experts say. By Isabel Kemp / September 12, 2023 / Gov & ... The FDAs nasal decongestants drug list, or monograph, has not been updated since 1995. The process for changing a monograph ... That would likely force consumers to switch to the behind-the-counter versions of the pills or to nasal sprays and drops that ...
Topical nasal decongestants, oral decongestants, nasal steroids, and antihistamines can be used to treat ETD. ... Nasal spray; may decrease number and activity of inflammatory cells, resulting in decreased nasal inflammation. Demonstrated no ... Oral decongestants. Class Summary. These agents are used to decrease swelling of eustachian tube and sinus mucosa. ... Nasal corticosteroids. Class Summary. These agents are used to decrease perieustachian tube inflammation. ...
It is recommended over oral systemic decongestants such as pseudoephedrine during breastfeeding.[1] Topical use on the face is ... Nasal Decongestants. Disclaimer: Information presented in this database is not meant as a substitute for professional judgment ... It is recommended over oral systemic decongestants such as pseudoephedrine during breastfeeding.[1] Topical use on the face is ... Decongestants and milk production. J Hum Lact 2000;16:294. Letter. PMID: 11155604. [PubMed: 11155604] ...
Tags Congestion, Consultants, Decongestant, Doesnt, FDA, Nasal, Popular, Relieve Paused Copay Requirements for Non-Citizens on ... A Popular Nasal Decongestant Doesnt Actually Relieve Congestion, FDA Consultants Say. September 13, 2023. by Wendy Rojas ... The FDAs list, or monograph, of nasal decongestant medications has not been updated since 1995. The process for changing a ... Popular #Nasal #Decongestant #Doesnt #Relieve #Congestion #FDA #Consultants. Image Source : www.npr.org ...
Nasal decongestants. *Camphorated oil. *Some moth repellents. *Topical pain relievers. *Vicks VapoRub ...
Keeping their nasal passages clear and clean is therefore an important part of the daily hygiene routine. It will help them to ... The nasal cavities of young infants are obviously very small and so can easily get blocked. Also, babies only ever breathe ... Nose hygiene (Isomar nasal spray and nasal aspirator, decongestant drops) Print Modified on: Mon, 6 Aug, 2018 at 11:58 AM ... This process requires two operations: nasal wash and mucus suction. The nasal wash can be carried out using a normal saline ...
Common OTC nasal decongestants with phenylephrine dont work in tablet form, experts say. Health Stuffy nose? Common OTC nasal ... common decongestants Dont experts form nasal nose OTC phenylephrine Stuffy tablet work ... for the common ingredient known as phenylephrine in popular nasal decongestants after an advisory panel to the agency found on ... petitioned the FDA to reevaluate the decision on allowing oral phenylephrine in nasal decongestants. ...
Learn more about Sudafed PE Childrens Nasal Decongestant ... to-date information on Sudafed PE Childrens Nasal Decongestant ... How was your experience with Sudafed PE Childrens Nasal Decongestant?. First, a little about yourself. Male Female ... Sudafed PE Childrens Nasal Decongestant is a brand name medication included in the following groups of medications: Adrenergic ... What tips would you provide a friend before taking Sudafed PE Childrens Nasal Decongestant?. / ...
CVS Nasal Decongestant PE. • CVS Health Daytime Soft Gels Severe Cold and Flu. • CVS Health Mucus Relief Sinus Severe ... If you purchased one of the nasal decongestant medicines containing phenylephrine listed above, contact us. Call 800-776-6044 ... NBCNews.com - What decongestants work? Here are some alternatives to phenylephrine. *NY Times - A Decongestant in Many Cold ... NBCNews.com - FDA panel says common over-the-counter decongestant doesnt work ...
Decongestant nasal sprays. Decongestant nasal sprays work by temporarily shrinking the blood vessels inside your nasal passages ... How to use nasal sprays. While most nasal sprays have similar instructions, its vital to check the instructions on your nasal ... Steroid nasal sprays. The most common type is a steroid nasal spray. These nasal sprays contain corticosteroids which work to ... Arm & Hammer Simply Saline Nasal Mist. This saline nasal mist is a natural way to experience allergy relief by flushing nasal ...
  • On Tuesday, Sept. 12, 2023 advisers to the Food and Drug Administration said that a different ingredient, phenylephrine, is ineffective at relieving nasal congestion. (wreg.com)
  • The term decongestant refers mainly to certain medications used to treat congestion of the nasal mucosa caused by infection or allergy in colds, rhinitis, or sinusitis (active congestion). (hellosites.net)
  • These decongestants effectively and quickly treat uncomfortable symptoms due to nasal congestion, such as a blocked nose, runny nose, and difficulty breathing. (hellosites.net)
  • Decongestants reduce nasal congestion by inducing peripheral vasoconstriction in the skin and mucosa. (hellosites.net)
  • Activation of alpha-1 receptors reduces blood volume in the nasal mucosa, leading to a decrease in congestion. (hellosites.net)
  • which relieves nasal congestion and protects against sinusitis. (frezyderm.com)
  • But FDA reviewers said their latest assessment reflects new testing insights into how quickly phenylephrine is metabolized when taken by mouth, leaving only trace levels that reach nasal passages to relieve congestion. (fox35orlando.com)
  • While writing an article on the health effects of sex and masturbation a while back, I came across a paper titled "Ejaculation as a Potential Treatment of Nasal Congestion in Mature Males" that hypothesized a connection between orgasm and nasal decongestion. (sexandpsychology.com)
  • Ejaculation as a potential treatment of nasal congestion in mature males. (sexandpsychology.com)
  • A 21-year-old college student presents with 7 days of sinus pressure, nasal congestion, coryza, itchy/watery eyes, and a scratchy sensation in his throat. (medscape.com)
  • Children can nose and nasal congestion, a decongestant nasal spray have lasting, thick nasal discharge for a long time without might make you feel better. (folkhalsomyndigheten.se)
  • FILE - Sudafed and other common nasal decongestants containing pseudoephedrine display behind the counter at a pharmacy. (komonews.com)
  • FILE - Sudafed and other common nasal decongestants containing pseudoephedrine are on display behind the counter at Hospital Discount Pharmacy in Edmond, Okla., Jan. 11, 2005. (wreg.com)
  • The FDA assembled its outside advisers to take another look at phenylephrine, which became the main drug in over-the-counter decongestants when medicines with an older ingredient - pseudoephedrine - were moved behind pharmacy counters. (wreg.com)
  • That would likely force consumers to switch to the behind-the-counter pseudoephedrine products or to phenylephrine-based nasal sprays and drops. (wreg.com)
  • It is recommended over oral systemic decongestants such as pseudoephedrine during breastfeeding. (nih.gov)
  • Some authors report as a possible aetiology the use of substances as pseudoephedrine in nasal decongestants and environmental toxins. (bvsalud.org)
  • Going back to 2015, there was a citizen's petition to remove phenylephrine from the over-the-counter drugs in the U.S. Back then, researchers had studies showing that as an oral decongestant, it's completely ineffective. (krvs.org)
  • That would likely force consumers to switch to the behind-the-counter pills or to nasal sprays and drops that contain phenylephrine, which are not under review. (abc27.com)
  • The group's negative opinion opens the door for the FDA to pull phenylephrine from a federal list of decongestants deemed effective for over-the-counter pills and liquids. (statedpodcast.com)
  • The U.S. Food and Drug Administration (FDA) is deliberating about removing the designation "generally recognized as safe and effective," or "GRASE," for the common ingredient known as phenylephrine in popular nasal decongestants after an advisory panel to the agency found on Tuesday the drug is ineffective when taken orally. (dcnewsusa.com)
  • Companies may be required to remove oral decongestants containing phenylephrine from shelves or reformulate them without the ingredient. (dcnewsusa.com)
  • The FDA held this advisory committee meeting to seek input from the advisory committee on new data on the effectiveness of oral phenylephrine as a nasal decongestant that have become available since the agency last examined the issue," an FDA spokesperson told Fox News Digital. (dcnewsusa.com)
  • The 16-member committee unanimously voted "no" to the following question: "Do the current scientific data that were presented support that the monograph dosage of orally administered phenylephrine is effective as a nasal decongestant? (dcnewsusa.com)
  • The FDA previously reviewed the topic in 2007, ultimately deciding to keep the drug on the market at the time - despite a systemic review that year finding "insufficient evidence that oral phenylephrine is effective for nonprescription use as a decongestant. (dcnewsusa.com)
  • Since 2007, several large placebo-controlled trials provide more definitive research that there is no evidence that standard and higher doses of oral phenylephrine relieves nasal decongestion. (dcnewsusa.com)
  • There should be no concern on the part of patients since there are many effective alternatives, including a topical nasal spray containing phenylephrine. (dcnewsusa.com)
  • Spraying phenylephrine, or the longer acting oxymetazoline, directly into the nose produces about 1 million times more drug in the nasal mucosa than swallowing it," he added. (dcnewsusa.com)
  • Spray for cleansing and moisturizing the nasal cavity, for the relief of cold symptoms and the protection of the nasal epithelium from dryness. (frezyderm.com)
  • Innovative Spray liquid which is converted tο protective Gel in nasal mucosa. (frezyderm.com)
  • Spray for cleansing and moisturizing the nasal cavity. (frezyderm.com)
  • Spray for cleansing the nasal cavity for the relief of cold symptoms. (frezyderm.com)
  • Each participant also provided data on nasal function before and after the use of a nasal decongestant spray as a comparison condition. (sexandpsychology.com)
  • In other words, nasal flow was worse prior to both orgasm and spray use, but it improved immediately after and remained better for up to an hour. (sexandpsychology.com)
  • However, after three hours, nasal functioning was still improved with the use of the spray, but it had returned to baseline in the orgasm condition. (sexandpsychology.com)
  • Corticosteroid nasal spray indicated for allergic rhinitis. (medscape.com)
  • These include topically as a nasal spray, as eye drops to dilate pupils, and intravenously into the bloodstream to reverse low blood pressure during surgery. (dcnewsusa.com)
  • Use a decongestant or saline nasal spray. (cdc.gov)
  • Topical nasal decongestants, oral decongestants, nasal steroids, and antihistamines can be used to treat ETD. (medscape.com)
  • Decongestant medications come in various oral forms (tablets, capsules, sachets) or topical use (nasal drops or sprays). (hellosites.net)
  • Depending on the indication, satisfactory nasal anesthesia may be obtained by the use of topical sprays and pledgets, local injections, regional nerve blocks, or a combination of these. (medscape.com)
  • Nasal anesthetic block is most commonly obtained by a combination of topical and infiltration techniques. (medscape.com)
  • First, topical agents may be sprayed, followed by placement into the nasal cavity of cotton pledgets soaked in topical agents. (medscape.com)
  • The leading decongestant used by millions of Americans looking for relief from a stuffy nose is likely no better than a dummy pill, according to government experts who reviewed the latest research on the long-questioned drug ingredient. (komonews.com)
  • For example, growths on the lining of the nose or sinuses, known as nasal polyps. (cdc.gov)
  • The understanding of nasal innervation can be simplified by dividing it into the internal (mucosal) and external (skin) aspects of the nose. (medscape.com)
  • [ 1 ] The external nose is innervated by the ophthalmic (V1) and maxillary (V2) nerves, which are the first 2 divisions of the trigeminal nerve (cranial nerve V). The superior aspect of the nose, including the tip, is supplied by the infratrochlear nerve (V1), the supratrochlear nerve (V1), and the external nasal branch of the anterior ethmoid nerve (V1). (medscape.com)
  • For a more complete discussion of nasal anatomy, see Nose Anatomy. (medscape.com)
  • If needed, the external nose is anesthetized by blocking the external nasal branch of the anterior ethmoid nerve, the infraorbital nerve, and the nasopalatine nerves. (medscape.com)
  • He had a similar presentation a year ago that resolved after treatment with a variety of medications, including decongestants, nasal steroids, and antibiotics. (medscape.com)
  • If you are uncertain about any of the information, consult your doctor or pharmacist.To apply nasal drops, wash your hands first. (medicinenet.com)
  • Check the product package or consult with your doctor or pharmacist about whether these nasal drops can be used in children.During pregnancy , this medication should be used only when clearly needed. (medicinenet.com)
  • If the baby has a bad cold, you can use decongestant drops, but only if these have been prescribed by your doctor. (chiedimidipiumamma.it)
  • Reduced Use of Antibiotics and Nasal Decongestants During Treatment with a Mouthwash Containing Delmopinol. (bvsalud.org)
  • In this paper , the number of treatments of different types of concomitant medication ( antibiotics , nasal decongestants and others) was used as a basis for statistical comparisons between the different test groups. (bvsalud.org)
  • The delmopinol HCl 0.2% solution in patients with gingivitis provided a statistically significant reduction of concomitant use of antibiotics and nasal decongestants . (bvsalud.org)
  • To stimulate the olfactory receptors, airborne molecules must pass through the nasal cavity with relatively turbulent air currents and contact the receptors. (medscape.com)
  • The internal nasal cavity may be subdivided into the nasal septum, the lateral walls, and the cribriform plate. (medscape.com)
  • The sphenopalatine ganglion (V2) is located at the posterior end of the middle turbinate and innervates the posterior nasal cavity. (medscape.com)
  • Innervation of the nasal cavity. (medscape.com)
  • Allergies can be treated with nasal steroid sprays, antihistamines, or allergy shots. (medlineplus.gov)
  • Those original versions of Sudafed and other medicines remain available without a prescription, but they're less popular and account for about one-fifth of the $2.2 billion market for oral decongestants. (wreg.com)
  • Oral decongestants are effective in stopping the main symptoms of a cold quickly. (hellosites.net)
  • These original versions of Sudafed and other medications remain available without a prescription, but are less popular and represent about a fifth of the $2.2 billion market for oral decongestants. (someviral.com)
  • The author of that paper argued that an ejaculatory orgasm is likely to have similar effects to taking a nasal decongestant because, like that medication, orgasm temporarily stimulates the sympathetic nervous system and causes vasoconstriction (a narrowing of blood vessels) [1]. (sexandpsychology.com)
  • Nasal decongestants are something very common these days and are used quite often for treating cough, and cold. (healthwire.co)
  • It was suggested that orgasm might therefore offer an alternative-and potentially healthier-treatment option for nasal issues because decongestant medications can have unwanted side effects and, if used too long, can actually worsen symptoms. (sexandpsychology.com)
  • In case of infectious rhinopharyngitis, allergic rhinitis (hay fever), or sinusitis, an inflammatory process and local irritation of the nasal mucous membrane trigger sneezing and hypersecretion of mucus responsible for the nasal discharge or obstruction. (hellosites.net)
  • This process requires two operations: nasal wash and mucus suction. (chiedimidipiumamma.it)
  • The olfactory neuroepithelium is located at the upper area of each nasal chamber adjacent to the cribriform plate, superior nasal septum, and superior-lateral nasal wall. (medscape.com)
  • The pledgets are removed after 5-10 minutes, and a solution of 1% lidocaine with 1:100,000 epinephrine may be injected along the nasal septum, lateral walls, and floor depending on the target area. (medscape.com)
  • Nasal Decongestion Products by FREZYDERM for free breathing from the first application. (frezyderm.com)
  • Activation of alpha-2 receptors decreases blood flow in the capillaries and reduces the extracellular fluid associated with rhinorrhea (nasal discharge). (hellosites.net)
  • usually experience thick nasal discharge that lasts for There is no medicine that can cure a cold. (folkhalsomyndigheten.se)
  • The patient saw an ENT specialist who diagnosed him with acute sinusitis and prescribed an inhaled nasal steroid and 14 days of levofloxacin at 500 mg orally once per day. (medscape.com)
  • The superior inner aspect of the lateral nasal wall is supplied by the anterior and posterior ethmoid nerves (V1). (medscape.com)
  • Keeping their nasal passages clear and clean is therefore an important part of the daily hygiene routine. (chiedimidipiumamma.it)
  • When we have a cold, the immune system sends white blood cells to fight the infection in our nasal passages. (dcnewsusa.com)
  • This nasal steroid is useful in ETD especially in patients who are also diagnosed with allergic rhinitis. (medscape.com)
  • Some reported symptoms of using nasal decongestants include nausea, vomiting, seizures, sudden onset of severe headache, confusion and visual disturbances. (healthwire.co)
  • While "the potential risk is considered to be very rare," the MHRA has advised people to discontinue the use of nasal decongestants and seek medical advice immediately in case the symptoms appear. (healthwire.co)
  • The nasal wash can be carried out using a normal saline solution (water and sodium chloride) or sea water rich in mineral salts and trace elements, available in single-dose bottles or larger containers. (chiedimidipiumamma.it)
  • But he says the markets would adjust, and the good news is that there are other over-the-counter medicines that are effective as nasal decongestants, including nasal sprays, so people would have alternative options, A. (krvs.org)
  • However, Nasal decongestants - which are also used in allergies - may be linked to seizures and stroke. (healthwire.co)
  • Because of these effects, nasal decongestant solutions should be used for short-term treatment and require a doctor's prescription. (hellosites.net)
  • may decrease number and activity of inflammatory cells, resulting in decreased nasal inflammation. (medscape.com)
  • Nasal anesthesia is required for the management of common routine and emergency procedures. (medscape.com)
  • These include nasal examination, nasotracheal intubation, management of nasal and facial trauma, increasingly common office-based sinonasal procedures, and management of facial and nasal abscesses. (medscape.com)
  • So for those seeking temporary nasal relief, an orgasm just might help for a bit. (sexandpsychology.com)
  • That said, these findings suggest that orgasm is a potential nasal decongestant and that it appears to work just as well as nasal sprays, at least for up to an hour. (sexandpsychology.com)
  • To reduce discomfort while performing a nasal block, several modifications can be employed. (medscape.com)
  • Participants obtained measures of nasal function themselves in their own homes using a portable medical device. (sexandpsychology.com)