Myoclonus
Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles. This condition may be a feature of some CENTRAL NERVOUS SYSTEM DISEASES; (e.g., EPILEPSY, MYOCLONIC). Nocturnal myoclonus is the principal feature of the NOCTURNAL MYOCLONUS SYNDROME. (From Adams et al., Principles of Neurology, 6th ed, pp102-3).
Epilepsies, Myoclonic
A clinically diverse group of epilepsy syndromes characterized either by myoclonic seizures or by myoclonus in association with other seizure types. Myoclonic epilepsy syndromes are divided into three subtypes based on etiology: familial, cryptogenic, and symptomatic (i.e., occurring secondary to known disease processes such as infections, hypoxic-ischemic injuries, trauma, etc.).
Myoclonic Epilepsies, Progressive
A heterogeneous group of primarily familial disorders characterized by myoclonic seizures, tonic-clonic seizures, ataxia, progressive intellectual deterioration, and neuronal degeneration. These include LAFORA DISEASE; MERRF SYNDROME; NEURONAL CEROID-LIPOFUSCINOSIS; sialidosis (see MUCOLIPIDOSES), and UNVERRICHT-LUNDBORG SYNDROME.
Lafora Disease
A form of stimulus sensitive myoclonic epilepsy inherited as an autosomal recessive condition. The most common presenting feature is a single seizure in the second decade of life. This is followed by progressive myoclonus, myoclonic seizures, tonic-clonic seizures, focal occipital seizures, intellectual decline, and severe motor and coordination impairments. Most affected individuals do not live past the age of 25 years. Concentric amyloid (Lafora) bodies are found in neurons, liver, skin, bone, and muscle (From Menkes, Textbook of Childhood Neurology, 5th ed, pp111-110)
Unverricht-Lundborg Syndrome
An autosomal recessive condition characterized by recurrent myoclonic and generalized seizures, ATAXIA, slowly progressive intellectual deterioration, dysarthria, and intention tremor. Myoclonic seizures are severe and continuous, and tend to be triggered by movement, stress, and sensory stimuli. The age of onset is between 8 and 13 years, and the condition is relatively frequent in the Baltic region, especially Finland. (From Menkes, Textbook of Child Neurology, 5th ed, pp109-110)
Cystatin B
Clonazepam
An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
Reflex, Abnormal
Myoclonic Cerebellar Dyssynergia
A condition marked by progressive CEREBELLAR ATAXIA combined with MYOCLONUS usually presenting in the third decade of life or later. Additional clinical features may include generalized and focal SEIZURES, spasticity, and DYSKINESIAS. Autosomal recessive and autosomal dominant patterns of inheritance have been reported. Pathologically, the dentate nucleus and brachium conjunctivum of the CEREBELLUM are atrophic, with variable involvement of the spinal cord, cerebellar cortex, and basal ganglia. (From Joynt, Clinical Neurology, 1991, Ch37, pp60-1)
Evoked Potentials, Somatosensory
MERRF Syndrome
A mitochondrial encephalomyopathy characterized clinically by a mixed seizure disorder, myoclonus, progressive ataxia, spasticity, and a mild myopathy. Dysarthria, optic atrophy, growth retardation, deafness, and dementia may also occur. This condition tends to present in childhood and to be transmitted via maternal lineage. Muscle biopsies reveal ragged-red fibers and respiratory chain enzymatic defects. (From Adams et al., Principles of Neurology, 6th ed, p986)
Protein Tyrosine Phosphatases, Non-Receptor
Lisuride
Muscle Rigidity
Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
Electroencephalography
Electromyography
Cerebellar Ataxia
Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)
Ataxia
Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
Effect of riluzole on the neurological and neuropathological changes in an animal model of cardiac arrest-induced movement disorder. (1/194)
Posthypoxic myoclonus and seizures precipitate as secondary neurological consequences in ischemic/hypoxic insults of the central nervous system. Neuronal hyperexcitation may be due to excessive activation of glutamatergic neurotransmission, an effect that has been shown to follow ischemic/hypoxic events. Therefore, riluzole, an anticonvulsant that inhibits the release of glutamate by stabilizing the inactivated state of activated voltage-sensitive sodium channels, was tested for its antimyoclonic and neuroprotective properties in the cardiac arrest-induced animal model of posthypoxic myoclonus. Riluzole (4-12 mg/kg i.p.) dose-dependently attenuated the audiogenic seizures and action myoclonus seen in this animal model. Histological examination using Nissl staining and the novel Fluoro-Jade histochemistry in cardiac-arrested animals showed an extensive neuronal degeneration in the hippocampus and cerebellum. Riluzole treatment almost completely prevented the neuronal degeneration in these brain areas. The neuroprotective effect was more pronounced in hippocampal pyramidal neurons and cerebellar Purkinje cells. These effects were seen at therapeutically relevant doses of riluzole, and the animals tolerated the treatment well. These findings indicate that the pathogenesis of posthypoxic myoclonus and seizure may involve excessive activation of glutamate neurotransmission, and that riluzole may serve as an effective pharmacological agent with neuroprotective potential for the treatment of neurological conditions associated with cardiac arrest in humans. (+info)Coherent cortical and muscle discharge in cortical myoclonus. (2/194)
There is increasing evidence in man that the cortical drive to motor neurons is rhythmic. This oscillatory drive may be exaggerated in patients with cortical myoclonus. Spectral analysis of surface bipolar EEG and EMG activity was performed in eight such patients. Only three cases had evidence of giant cortical evoked potentials or a cortical correlate on back-averaging at the time of study. In six subjects, significant coherence between contralateral and vertex EEG and EMG was observed in ranges similar to that previously reported for normal subjects (15-30 and 30-60 Hz). Three out of these six subjects also had significant coherence at higher frequencies (up to 175 Hz). All eight patients had a correlate in the cumulant density estimate between EEG and contralateral EMG. EMG lagged EEG by about 14, 25 and 35 ms for the muscles of the forearm, hand and foot, respectively. These delays were estimated from the slope of the phase curves and the timing of the peaks in the cumulant density estimates, and are appropriate for conduction in fast pyramidal pathways. The results provide clear evidence of a cortical drive synchronizing muscle discharge over a broad range of frequencies in patients with cortical myoclonus. Fourier analysis is a promising technique in the diagnosis and investigation of such patients. (+info)Quantization of continuous arm movements in humans with brain injury. (3/194)
Segmentation of apparently continuous movement has been reported for over a century by human movement researchers, but the existence of primitive submovements has never been proved. In 20 patients recovering from a single cerebral vascular accident (stroke), we identified the apparent submovements that composed a continuous arm motion in an unloaded task. Kinematic analysis demonstrated a submovement speed profile that was invariant across patients with different brain lesions and provided experimental verification of the detailed shape of primitive submovements. The submovement shape was unaffected by its peak speed, and to test further the invariance of shape with speed, we analyzed movement behavior in a patient with myoclonus. This patient occasionally made involuntary shock-like arm movements, which occurred near the maximum capacity of the neuromuscular system, exhibited speed profiles that were comparable to those identified in stroke patients, and were also independent of speed. (+info)Association of a missense change in the D2 dopamine receptor with myoclonus dystonia. (4/194)
Hereditary autosomal dominant myoclonus dystonia (MD) is a movement disorder characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Although various large families with MD have been described, no positive linkage has been found to a chromosomal location. We report a family with eight members with MD. Linkage analysis identified a 23-centimorgan region on chromosome 11q23 that cosegregates with the disease state (maximum multipoint logarithm of odds score = 2.96 at D11S897). This region contains an excellent candidate gene for involvement in the etiology of MD, the D2 dopamine receptor (DRD2) gene. Neurotransmission mediated by DRD2 is known to have a key role in the control of movement and also has been implicated in reward and reinforcement mechanisms and psychiatric disorders. Sequencing of the coding region of DRD2 indicated that all affected and obligate carriers were heterozygous for a Val154Ile change in exon 3 of the protein, which is highly conserved across species. This change was found neither in other unaffected members of the pedigree nor in 250 control chromosomes. Our finding provides evidence for the involvement of DRD2 in a disorder of the central nervous system and should lead to further insight into the function of the dopaminergic system in dystonia and other movement and mood disorders. (+info)Palatal myoclonus in postinfectious opsoclonus myoclonus syndrome : a case report. (5/194)
An adult male presenting with acute onset opsoclonus, myoclonus and cerebellar ataxia is being reported. Patient had myoclonus involving limbs and palate. There are only a few reported cases associated with palatal myoclonus. Patient showed gradual spontaneous recovery. Possibility of underlying malignancy was excluded by detailed investigations. (+info)Hypertrophic olivary degeneration: metaanalysis of the temporal evolution of MR findings. (6/194)
BACKGROUND AND PURPOSE: Hypertrophic olivary degeneration (HOD) is usually caused by a lesion in the triangle of Guillain and Mollaret and presents clinically as palatal tremor. Although the imaging features have been well described, the temporal course of hypertrophy and T2 signal increase in the inferior olivary nucleus (ION) has not been fully characterized. Our purpose was to evaluate the time course of MR imaging features of HOD caused by a lesion within the triangle of Guillain and Mollaret. METHODS: The temporal progression of HOD in 45 patients with symptomatic palatal tremor was obtained by extrapolation of combined MR imaging data from six patients treated at our institution and 39 patients reported in the literature. The MR examinations and reports were reviewed for presence of hyperintense signal in the ION on T2-weighted images, hypertrophy of the ION, and an inciting lesion in the triangle of Guillain and Mollaret. The interval between the MR examination and the inciting lesion was determined. RESULTS: Increased olivary signal on T2-weighted images first appeared 1 month after the inciting lesion and persisted for at least 3 to 4 years. Olivary hypertrophy initially developed 6 months after the acute event and resolved by 3 to 4 years. CONCLUSION: Visible changes on MR images in the ION in patients with a lesion in the triangle of Guillain and Mollaret correlate well with the described sequential histopathologic findings. (+info)Role of primary sensorimotor cortices in generating inhibitory motor response in humans. (7/194)
To clarify the mechanism by which inhibitory motor responses such as cortical negative myoclonus are generated in humans, three patients with medically intractable partial epilepsy (two with frontal lobe epilepsy and one with parietal lobe epilepsy) were studied by means of direct cortical stimulation with a single electric pulse through subdural electrodes. All underwent chronic long-term video/EEG monitoring, cortical mapping by 50 Hz electric cortical stimulation and recording of cortical somatosensory evoked potentials with chronically implanted subdural grid electrodes (3 mm in diameter and centre-to-centre distance of 1 cm) to map both epileptogenic and functional zones. After these clinical evaluations, cortical stimulation by single electric pulse (0.3 ms duration, 1 Hz) was carried out through pairs of subdural electrodes located at the primary sensorimotor area (MI-SI), pre-supplementary motor area (pre-SMA) and lateral negative motor area (lateral NMA), while surface EMG was recorded from the muscles of the contralateral hand. The results showed that (i) in all subjects, single pulse stimulation of MI-SI elicited a motor evoked potential (MEP) followed by a silent period (SP) in the contralateral distal hand muscles, the latter lasting 300 ms after the stimulus. The duration of SP was proportional to the size of the preceding MEP. In one subject, SP without any preceding MEP was elicited, and, in another subject, there was a short SP immediately before MEP in the contralateral thenar muscle. (ii) Following the stimulation of either pre-SMA or lateral NMA, no SP was observed. It is concluded that the inhibitory mechanism within the MI-SI, but probably not in the non-primary motor areas, either closely linked to or completely independent of excitation, most likely plays an important role in eliciting brief negative motor phenomena such as cortical negative myoclonus or SP. (+info)Palatal myoclonus: report of two cases. (8/194)
We describe two cases of palatal myoclonus (PM), one essential and another secondary to a stroke. Case 1: a 64 years old female who developed clicking sounds in both ears after a stroke and three years later on noticed a progressive involuntary movement of the throat associated with rhythmic contractions of the soft palate, muscles of tongue and throat. MRI showed an ischemic area in brainstem. The patient had a partial response to the use of sumatriptan 6 mg subcutaneously. Case 2: a 66 years old female who began with ear clicking at left ear that worsed slowly associated with tinnitus and arrhythmic movements of soft palate and an audible click at left ear. Brain MRI was normal; audiometry showed bilateral neurosensory loss. She was prescribed clonazepan 1 mg daily with complete recovery. Primary and secondary palatal myoclonus share the same clinical features but probably have different pathophysiological underlying mechanisms. (+info)
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Cortical myoclonus in angelman syndrome.
Myoclonus
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Myoclonus epilepsy and ataxia due to KCNC1 mutation: Analysis of 20 cases and K<sup>+</sup> channel...
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Tricyclic Antidepressant Poisoning: Reversal of Coma, Choreoathetosis, and Myoclonus by Physostigmine | JAMA | JAMA Network
Guilleminault, C. and Raynal, D. (1975) Sleep-related periodic myoclonus in patients complaining of insomnia. Transactions of...
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Myoclonus
Spinal myoclonus is myoclonus originating in the spinal cord, including segmental and propriospinal myoclonus. The latter is ... Action myoclonus is the most disabling form of myoclonus and can affect the arms, legs, face, and even the voice. It is often ... "Myoclonus Treatments and Drugs." Mayo Clinic.org. Mayo Clinic, n.d. Web. 01 May 2015. "NINDS Myoclonus Information Page." Ninds ... Anatomically, myoclonus may originate from lesions of the cortex, subcortex or spinal cord. The presence of myoclonus above the ...
Palatal myoclonus
... it is known as oculopalatal myoclonus. Signs and symptoms of Palatal Myoclonus include: - A rhythmic clicking sound in the ear ... Palatal myoclonus is a rare condition in which there are rhythmic jerky movements or a rapid spasm of the palatal (roof of the ... Park, S. N.; Park, K. H.; Kim, D. H.; Yeo, S. W. (Feb 7, 2011). "Palatal Myoclonus Associated with Orofacial Buccal Dystonia". ... A rare case of palatal myoclonus that associated with orofacial buccal dystonia has been treated with Botulinum toxin A ( ...
Opsoclonus myoclonus syndrome
... (OMS), also known as opsoclonus-myoclonus-ataxia (OMA), is a rare neurological disorder of ... myoclonus, ataxia, (61) and encephalopathy (62) may be the most complete, but opsoclonus-myoclonus will be used here. Mitchell ... Paraneoplastic Opsoclonus-Myoclonus Ataxia (POMA) "Orphanet: Opsoclonus myoclonus syndrome". www.orpha.net. Retrieved 29 ... "Opsoclonus-Myoclonus Syndrome - NORD (National Organization for Rare Disorders)". Retrieved 2015-09-04. Cooper R, Khakoo Y, ...
Progressive myoclonus epilepsy
In Myoclonus epilepsy with ragged-red fibers (MERRF) the person experiences generalized epilepsy along with myoclonus, weakness ... The most common symptom of PME is myoclonus. The myoclonus can be fragmented or multifocal and can be triggered by posture, ... Unverricht-Lundborg disease (Baltic myoclonus) Myoclonus epilepsy and ragged red fibres (MERRF syndrome) Lafora disease ... Nevertheless, severe myoclonus can lead to injury by falling and becoming reliant on a wheelchair. Because PME is so rare it is ...
Benign neonatal sleep myoclonus
... (BNSM) is the occurrence of myoclonus (jerky movements) during sleep. It is not associated with ... Di Capua, M; Fusco, L; Ricci, S; Vigevano, F (April 1993). "Benign neonatal sleep myoclonus: clinical features and video- ... The myoclonic jerks occur during non-REM sleep.[citation needed] "Benign Neonatal Sleep Myoclonus: eMedicine Pediatrics: ...
GOSR2-related progressive myoclonus ataxia
... , also known as Progressive myoclonic epilepsy type 6 is a rare genetic type of ... "GOSR2-related progressive myoclonus ataxia , Genetic and Rare Diseases Information Center (GARD) - an NCATS Program". web. ... "A mutation in the Golgi Qb-SNARE gene GOSR2 causes progressive myoclonus epilepsy with early ataxia". American Journal of Human ... clinical characterization of progressive myoclonus ataxia caused by GOSR2 mutation". Movement Disorders. 29 (1): 139-143. doi: ...
PRICKLE1-related progressive myoclonus epilepsy with ataxia
... is a very rare genetic disorder which is characterized by myoclonic ... Ataxia is usually one of the first symptoms of this disorder, followed by early/mid childhood-onset myoclonus, which can lead ... "PRICKLE1-related progressive myoclonus epilepsy with ataxia: MedlinePlus Genetics". medlineplus.gov. Retrieved 2022-06-06. ...
Henry Head
Case of myoclonus. (Brain, 1905, 28, 362.) With J. Sherren: The consequences of injury to the peripheral nerves in man. (Brain ...
Lafora disease
"Lafora Progressive Myoclonus Epilepsy". Epilepsy Foundation. Retrieved 2017-12-13. Lafora's disease at Who Named It? Tenny, ... "Lafora Progressive Myoclonus Epilepsy". Epilepsy Foundation. Retrieved 2017-12-12. "Lafora Disease in Dogs - Symptoms, Causes, ... Lafora disease is a rare, adult-onset and autosomal recessive genetic disorder which results in myoclonus epilepsy and usually ... "Lafora progressive myoclonus epilepsy". Genetics Home Reference. Retrieved 2017-12-12. Turnbull, Julie; Striano, Pasquale; ...
Frederick Andermann
Action myoclonus-renal failure syndrome: a previously unrecognized neurological disorder unmasked by advances in nephrology. In ... Myoclonus (Advances in Neurology, Vol 43). New York, Raven Press 1986: 87-103 "Lifetime Achievement Award - Frederick Andermann ...
List of OMIM disorder codes
NPR2 Action myoclonus-renal failure syndrome; 254900; SCARB2 Acyl-CoA dehydrogenase, long chain, deficiency of; 201460; ACADL ...
Lance-Adams syndrome
It is a disease that presents Myoclonus as a sequela of hypoxic disorders in the brain due to asphyxiation and cardiopulmonary ... 357-360, doi:10.11251/ojjscn.41.357 Lance JW, Adams RD (1963). "The Syndrome of Intention or Action Myoclonus as a Sequel to ... A condition that presents with functional myoclonus associated with increased cortical excitability in a few weeks. It was ... S. Frucht; S. Fahn (2000). "The clinical spectrum of posthypoxic myoclonus". Movement Disorders. 15 (Suppl 1): 2-7. doi:10.1002 ...
Myoclonic epilepsy
... "positive myoclonus," and a brief loss of muscular tone is known as "negative myoclonus". Myoclonus which occurred at rest ... Myoclonus can be a source of substantial disability with impairment in daily activities. Myoclonus can be termed positive or ... Myoclonus jerks can be epileptic or not epileptic. Epileptic myoclonus is an elementary electroclinical manifestation of ... The prevalence of Lafora progressive myoclonus epilepsy is unknown. Most common cause of Lafora progressive myoclonus epilepsy ...
Myoclonic dystonia
Myoclonus can be positive or negative; positive myoclonus results from brief spurts of muscle activity and negative myoclonus ... Myoclonus is a precursor effect to myoclonus dystonia and most commonly begins in childhood or adolescence. Myoclonus is ... Although myoclonus and dystonia are present in myoclonus dystonia patients, optimum treatment for myoclonus dystonia differs ... myoclonus and dystonia. For the majority of individuals with myoclonus dystonia, the myoclonus component of the disorder is ...
Centre for Applied Genomics
October 2003). "Mutations in NHLRC1 cause progressive myoclonus epilepsy". Nature Genetics. 35 (2): 125-7. doi:10.1038/ng1238. ...
Amyotrophy
... myoclonus". BMJ Case Reports. 2013: bcr2012008245. doi:10.1136/bcr-2012-008245. ISSN 1757-790X. PMC 3604390. PMID 23386493. v t ...
Stephen W. Scherer
Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy. 1998. Nature Genetics ... Mutations in NHLRC1 cause progressive myoclonus epilepsy. 2003. Nature Genetics 35, 125-127. Google Scholar citation Gene ...
Spinal muscular atrophy with progressive myoclonic epilepsy
Jankovic, J.; Rivera, V. M. (1979). "Hereditary myoclonus and progressive distal muscular atrophy". Annals of Neurology. 6 (3 ... Spinal muscular atrophies Progressive myoclonus epilepsy Haliloglu, G.; Chattopadhyay, A.; Skorodis, L.; Manzur, A.; Mercuri, E ...
Prednimustine
230-. ISBN 978-94-011-4439-1. Monnerat C, Gander M, Leyvraz S (January 1997). "A rare case of prednimustine-induced myoclonus ... Rarely, it has been associated with myoclonus. List of hormonal cytostatic antineoplastic agents List of corticosteroid esters ...
NHLRC1
GeneReviews/NCBI/NIH/UW entry on Progressive Myoclonus Epilepsy, Lafora Type v t e (Genes on human chromosome 6, All stub ... 2006). "Novel glycogen synthase kinase 3 and ubiquitination pathways in progressive myoclonus epilepsy". Hum. Mol. Genet. 14 ( ... "Mutations in NHLRC1 cause progressive myoclonus epilepsy". Nat Genet. 35 (2): 125-7. doi:10.1038/ng1238. PMID 12958597. S2CID ...
Anti-Hu associated encephalitis
Opsoclonus-myoclonus syndrome (OMS) is a condition that develops in children as a result of anti-Hu antibodies. The illness ... Meena JP, Seth R, Chakrabarty B, Gulati S, Agrawala S, Naranje P (2016). "Neuroblastoma presenting as opsoclonus-myoclonus: A ... Ketterl TG, Messinger YH, Niess DR, Gilles E, Engel WK, Perkins JL (2013). "Ofatumumab for refractory opsoclonus-myoclonus ... Blaes F, Fühlhuber V, Preissner KT (2007). "Identification of autoantigens in pediatric opsoclonus-myoclonus syndrome". Expert ...
SGCE
2004). "Severe myoclonus-dystonia syndrome associated with a novel epsilon-sarcoglycan gene truncating mutation". Am. J. Med. ... GeneReviews/NIH/NCBI/UW entry on Myoclonus-Dystonia LOVD mutation database: SGCE v t e (Genes on human chromosome 7, All stub ... 2002). "Myoclonus-dystonia syndrome: epsilon-sarcoglycan mutations and phenotype". Ann. Neurol. 52 (4): 489-92. doi:10.1002/ana ... 1999). "Localization of a gene for myoclonus-dystonia to chromosome 7q21-q31". Ann. Neurol. 46 (5): 794-8. doi:10.1002/1531- ...
Valproate
Sotaniemi K (July 1982). "Valproic acid in the treatment of nonepileptic myoclonus". Archives of Neurology. 39 (7): 448-449. ...
Dentate nucleus
Alzheimer's disease (AD) with myoclonus: There is an increase in mean volume of large neurons and a decrease in mean volume of ... Morphological changes in the dentate nucleus may contribute to the pathological substrate of myoclonus in AD. Dissection of ... Cerebellar dentate nucleus in Alzheimer's disease with myoclonus. [Article]. Dementia and Geriatric Cognitive Disorders, 10(2 ... small neurons in the dentate nucleus in AD with myoclonus. ...
Poppy tea
When ingested, thebaine causes nausea, vomiting, and myoclonus. Thebaine is an important precursor for manufacture of ...
David Perlmutter
November 1986). "Spinal Myoclonus Associated With HTLV III/LAV Infection". Arch. Neurol. 43 (11): 1203-1204. doi:10.1001/ ...
PGM3 deficiency
Oral motor deficits, dysarthria, developmental delay, ataxia, myoclonus, seizure and mild sensory loss have all been identified ... myoclonus, and cognitive impairment". American Journal of Medical Genetics. Part A. 125A (2): 145-51. doi:10.1002/ajmg.a.20595 ...
Stiff-person syndrome
It is then distinguished by the development of myoclonus as well as seizures and ataxia in some cases. Patients with SPS ... Late in the disease's progression, hypnagogic myoclonus can occur. Tachycardia and hypertension are sometimes also present. ...
Gluten-free diet
Myoclonus, palatal tremor, and opsoclonus-myoclonus may also appear. Early diagnosis and treatment with a gluten-free diet can ...
Gluten-related disorders
Myoclonus, palatal tremor, and opsoclonus-myoclonus may also appear. Early diagnosis and treatment with a gluten-free diet can ...
Myoclonus-dystonia: MedlinePlus Genetics
Myoclonus-dystonia is a movement disorder that typically affects the neck, torso, and arms. Explore symptoms, inheritance, ... Some people with myoclonus-dystonia do not have an identified mutation in any of the known associated genes. The cause of the ... Mutations in the SGCE gene cause 30 to 50 percent of cases of myoclonus-dystonia. The SGCE gene provides instructions for ... In myoclonus-dystonia, dystonia often affects one or both hands, causing writers cramp, or the neck, causing the head to turn ...
Lafora progressive myoclonus epilepsy: MedlinePlus Genetics
Lafora progressive myoclonus epilepsy is a brain disorder characterized by recurrent seizures (epilepsy) and a decline in ... Lafora progressive myoclonus epilepsy can be caused by mutations in either the EPM2A gene or the NHLRC1 gene. These genes ... In the later stages of Lafora progressive myoclonus epilepsy, myoclonus often occurs continuously and affects the entire body. ... Myoclonus can occur when an affected person is at rest, and it is made worse by motion, excitement, or flashing light (photic ...
Myoclonus - Marijuana Doctors | Online Medical Card Directory
What Is Myoclonus?. Myoclonus describes a range of quick, sudden and involuntary muscle jerks that can happen in a single ... Types of Myoclonus. The defining characteristic of myoclonus is the muscle jerking. However, there are different kinds of ... Marijuana and Myoclonus Treatment. When using medical cannabis for myoclonus, its important to work with an experienced ... Side Effects of Marijuana for Myoclonus. While medical marijuana is a natural option for treating myoclonus, it still has some ...
Piracetam relieves symptoms in progressive myoclonus epilepsy: a multicentre, randomised, double blind, crossover study...
Piracetam relieves symptoms in progressive myoclonus epilepsy: a multicentre, randomised, double blind, crossover study ... Piracetam relieves symptoms in progressive myoclonus epilepsy: a multicentre, randomised, double blind, crossover study ... Piracetam relieves symptoms in progressive myoclonus epilepsy: a multicentre, randomised, double blind, crossover study ...
Opsoclonus-myoclonus syndrome after adenovirus infection | SpringerPlus | Full Text
A 22-month-old girl at onset of opsoclonus-myoclonus syndrome (OMS) was followed for 8 years. Adenovirus (type C subtype 3 ... Syrbe, S., Merkenschlager, A., Bernhard, M.K. et al. Opsoclonus-myoclonus syndrome after adenovirus infection. SpringerPlus 4, ... Opsoclonus-myoclonus-(ataxia) syndrome (OMS), or dancing-eyes syndrome, is a rare encephalopathy, seen mainly in infancy with ... Sagittal T2-weighted cranial magnetic resonance images at onset of opsoclonus-myoclonus syndrome (a) and 5 years later (b), ...
ZFIN Human Disease: progressive myoclonus epilepsy 10
Myoclonus in patient on fluoxetine after receiving fentanyl and low-dose methylene blue during sentinel lymph node biopsy<...
Myoclonus in patient on fluoxetine after receiving fentanyl and low-dose methylene blue during sentinel lymph node biopsy. In: ... Myoclonus in patient on fluoxetine after receiving fentanyl and low-dose methylene blue during sentinel lymph node biopsy. / ... Myoclonus in patient on fluoxetine after receiving fentanyl and low-dose methylene blue during sentinel lymph node biopsy. ... T1 - Myoclonus in patient on fluoxetine after receiving fentanyl and low-dose methylene blue during sentinel lymph node biopsy ...
myoclonus
Occasional myoclonic jerks occur between seizures in patients with idiopathic epilepsy, and myoclonus is a major feature of ... myoclonus - [mī äk′lə nəs] n. [ MYO + CLONUS] involuntary twitching or spasm of a muscle or muscles myoclonic [mī΄ō klän′ik] ... myoclonus epilepsia - myoclonus epilepsia. См. миоклонус эпилепсия. (Источник: «Англо русский толковый словарь генетических ... myoclonus. n.. a sudden spasm of the muscles. Occasional myoclonic jerks occur between seizures in patients with idiopathic ...
Dr. Amer Alshekhlee, MD - Vascular Neurology Specialist in Saint Louis, MO | Healthgrades
Myoclonus EEG Pattern Predicts Functionally Favorable Survival
Myoclonus Subtypes The majority of patients will go on to die of brain injury after admission for cardiac arrest, and those who ... "In some ways, if you had a choice after cardiac arrest, youd actually like to have that kind of myoclonus because it implies ... Cite this: Myoclonus EEG Pattern After Cardiac Arrest May Predict Functionally Favorable Survival - Medscape - Sep 01, 2016. ... None of the myoclonus subgroups with any PAMM pattern other than pattern 2 had functionally favorable survival. Interestingly, ...
Clinical neurophysiology of myoclonus - Oxford Neuroscience
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IMSEAR at SEARO: A case of acute reversible opsoclonus-myoclonus syndrome.
Myoclonus Treatment Ottawa | Broadview Spine & Health Centre
We Have Experience And Expertise When It Comes To Diagnosing And Treating Myoclonus. ... Myoclonus: An Involuntary Movement Disorder Thats More Frustrating Than Alarming. Myoclonus is more commonly known as "Muscle ... Sometimes myoclonus occurs as the result of a neurological disorder, e.g. epilepsy, out-of-sorts metabolism or a reaction to ... Myoclonus intensity and length can vary. Sometimes its locally isolated to a specific part of the body; others feel it all ...
Benign Neonatal Sleep Myoclonus Treatment & Management: Medical Care, Consultations, Long-Term Monitoring
encoded search term (Benign Neonatal Sleep Myoclonus) and Benign Neonatal Sleep Myoclonus What to Read Next on Medscape ... Benign Neonatal Sleep Myoclonus Treatment & Management. Updated: Dec 17, 2019 * Author: Marc P DiFazio, MD; Chief Editor: Ted ... Benign neonatal sleep myoclonus: Our experience of 15 Japanese cases. Brain Dev. 2015 Jan. 37(1):71-5. [QxMD MEDLINE Link]. ... Benign neonatal sleep myoclonus: a review of the literature. Pediatrics. 2010 Apr. 125(4):e919-24. [QxMD MEDLINE Link]. ...
Diagnostic Criteria | Creutzfeldt-Jakob Disease, Classic (CJD) | Prion Disease | CDC
EEG in Dementia and Encephalopathy: Overview, Dementia, Vascular Dementia
Action myoclonus. Action myoclonus consists of arrhythmic muscular jerking induced by voluntary movement. It can be made worse ... Action myoclonus usually responds to sodium valproate or clonazepam, and some patients with posthypoxic action myoclonus may ... Generalized myoclonus. Generalized myoclonus in comatose survivors after CPR implies a poor prognosis despite improvement of ... The typical electrophysiologic correlates of myoclonus in AD are similar to those of cortical reflex myoclonus, with a focal, ...
Nonsteroidal Anti-inflammatory Drug (NSAID) Toxicity: Practice Essentials, Pathophysiology, Etiology
FEJERMAN SYNDROME (BENIGN NONEPILEPTIC MYOCLONUS OF INFANCY) | Mironov | Epilepsy and paroxysmal conditions
Table - West Nile Virus-associated Flaccid Paralysis Outcome - Volume 12, Number 3-March 2006 - Emerging Infectious Diseases...
Stimulus-induced myoclonus treatedeffectively with clonazepam in genetically confirmed Coffin-Lowry syndrome | AVESİS
Benign Childhood Epilepsy: Overview, Benign Familial Neonatal Convulsions, Benign Idiopathic Neonatal Convulsions
6] Dravet and Bureau found that the syndrome occurs in 7% of children with myoclonus and in 2% of epileptic children aged 1-36 ... During light sleep, they almost always are accompanied by myoclonus. The discharges gradually disappear during slow-wave sleep ... Ictal EEG recordings show generalized fast SW or PSW accompanying the myoclonus. ...
Efexor XL 37.5 mg hard prolonged release capsules | Doc History | Medicines.ie
... myoclonus; Rare: akathisia, ataxia and disorders of balance and coordination, speech disorders including dysarthria, mania or ... myoclonus; Rare: akathisia, ataxia and disorders of balance and coordination, speech disorders including dysarthria, mania or ... myoclonus; Rare: ataxia and disorders of balance and coordination, speech disorders including dysarthria, mania or hypomania ( ... myoclonus; Rare: ataxia and disorders of balance and coordination, speech disorders including dysarthria, mania or hypomania ( ...
Familial Cortical Myoclonic Tremor and Epilepsy, an Enigmatic Disorder: From Phenotypes to Pathophysiology and Genetics. A...
Clinical features may also include proximal myoclonus and mild progression with aging. Valproate or levetiracetam, with or ... is characterized by distal tremulous myoclonus, generalized seizures, and signs of cortical reflex myoclonus. FCMTE has been ... Methods: We carried out a PubMed search, using a combination of the following search terms: cortical tremor, myoclonus, ... Clinical features may also include proximal myoclonus and mild progression with aging. Valproate or levetiracetam, with or ...
Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome - Nuffield Department of Medicine
ObjectiveTo identify neuronal surface antibodies in opsoclonus myoclonus ataxia syndrome (OMAS) using contemporary antigen ... Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome Share Share Share ... ObjectiveTo identify neuronal surface antibodies in opsoclonus myoclonus ataxia syndrome (OMAS) using contemporary antigen ...
Botulism | Encyclopedia.com
Wilson's Disease
Myoclonus: what is it, why do these spasms arise and how are they treated? - Salutio.org
In general, myoclonus is physiological and is not a cause for concern. However, some situations that cause disorders in the ... Myoclonus are brief, rapid, involuntary and sudden movements, similar to a shock, which consists of simple or repetitive ... Home/Library/Myoclonus: what is it, why do these spasms arise and how are they treated?. Library Myoclonus: what is it, why do ... 1. Physiological myoclonus. This type of myoclonus occurs in normal and healthy people and sometimes requires treatment, as is ...
PDF] Calbindin-D28k is a more reliable marker of human Purkinje cells than standard Nissl stains: A stereological experiment |...
Nocturnal MyoclonusEpilepsyTremorDystoniaMyoclonicForms of myoclonusSymptomaticJerksEpileptic disorderAtaxiaEasing myoclonus symptomsSyndromeType of myoclonusForm of myoclonusTypes of myoclonusCause of myoclonusSymptoms of myoclonusEssential myoclonusCorticalSyndromesDiagnosisDisordersInvoluntaryPathologicParkinson's DiseaseSecondaryDisorderBrainContractionsMultifocalSpinal cordPhysiologicalSymptomBenignSpasmsHiccupsNeuronalClinical featuresFrequentMusclesInterfere
Nocturnal Myoclonus5
- Nocturnal Myoclonus Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
- This graph shows the total number of publications written about "Nocturnal Myoclonus Syndrome" by people in this website by year, and whether "Nocturnal Myoclonus Syndrome" was a major or minor topic of these publications. (ucdenver.edu)
- Below are the most recent publications written about "Nocturnal Myoclonus Syndrome" by people in Profiles. (ucdenver.edu)
- Myoclonic jerks on falling asleep ( nocturnal myoclonus ) occur in normal individuals. (en-academic.com)
- 1 Periodic limb movements during sleep (formerly called nocturnal myoclonus) 2 accompany RLS in most cases. (tremorjournal.org)
Epilepsy22
- Other forms of myoclonus may occur because of a nervous system (neurological) disorder, such as epilepsy, a metabolic condition, or a reaction to a medication. (sparrow.org)
- Lafora progressive myoclonus epilepsy is a brain disorder characterized by recurrent seizures (epilepsy) and a decline in intellectual function. (medlineplus.gov)
- In the later stages of Lafora progressive myoclonus epilepsy, myoclonus often occurs continuously and affects the entire body. (medlineplus.gov)
- Several types of seizures commonly occur in people with Lafora progressive myoclonus epilepsy. (medlineplus.gov)
- People with Lafora progressive myoclonus epilepsy generally survive up to 10 years after symptoms first appear. (medlineplus.gov)
- The prevalence of Lafora progressive myoclonus epilepsy is unknown. (medlineplus.gov)
- Lafora progressive myoclonus epilepsy can be caused by mutations in either the EPM2A gene or the NHLRC1 gene. (medlineplus.gov)
- Researchers have discovered that people with Lafora progressive myoclonus epilepsy have distinctive clumps called Lafora bodies within their cells. (medlineplus.gov)
- Although Lafora bodies are found in many of the body's tissues, the signs and symptoms of Lafora progressive myoclonus epilepsy are limited to the nervous system. (medlineplus.gov)
- Mutations in the EPM2A and NHLRC1 genes account for 80 percent to 90 percent of all cases of Lafora progressive myoclonus epilepsy. (medlineplus.gov)
- Many of the same prescription drugs used to treat epilepsy are also used to treat myoclonus, even if epilepsy isn't the underlying cause. (marijuanadoctors.com)
- Since medical cannabis is effective in treating epilepsy in many people, it may also be effective in treating your myoclonus. (marijuanadoctors.com)
- A progressive myoclonus epilepsy characterized by onset of progressive myoclonus, ataxia, spasticity, dysarthria, and cognitive decline in the first decade of life that has_material_basis_in homozygous or compoud heterozygous mutation in PRDM8 on chromosome 4q21.21. (zfin.org)
- Occasional myoclonic jerks occur between seizures in patients with idiopathic epilepsy , and myoclonus is a major feature of some progressive neurological illnesses with extensive degeneration of the brain cells (including the spongiform encephalopathies). (en-academic.com)
- Myoclonus may occur because of a neurological disorder such as epilepsy, any metabolic disorders or adverse drug reactions. (gleneaglesglobalhospitals.com)
- If benign neonatal sleep myoclonus (BNSM) is misidentified as epilepsy, treatment could result in a medicolegal challenge, especially because the medication-related side effects of anticonvulsants have become better recognized. (medscape.com)
- Benign sleep myoclonus in infancy mistaken for epilepsy. (medscape.com)
- MSE, which usually begins within 24 hours of injury, has shown EEG patterns of "generalized polyspikes, spikes, or sharp waves that are time-locked with clinical myoclonus, although the term 'status epilepticus' may be a misnomer, as PAMM bears little resemblance to status epilepticus or myoclonic epilepsy," write the researchers. (medscape.com)
- Objective Autosomal dominant cortical myoclonus and epilepsy (ADCME) is characterized by distal, fairly rhythmic myoclonus and epilepsy with variable severity. (elsevier.com)
- Sometimes myoclonus occurs as the result of a neurological disorder, e.g. epilepsy, out-of-sorts metabolism or a reaction to medication. (broadviewhealthcentre.com)
- Autosomal dominant familial cortical myoclonic tremor and epilepsy (FCMTE) is characterized by distal tremulous myoclonus, generalized seizures, and signs of cortical reflex myoclonus. (nih.gov)
- However, some situations that cause disorders in the central nervous system, such as epilepsy, the presence of metabolic problems or a reaction to the ingestion of certain medications can cause myoclonus. (salutio.org)
Tremor2
- RESULTS: The core phenotype consisted of childhood-onset dystonia predominantly affecting hands and neck, with a fast tremor with superimposed myoclonus, and in some, subtle cerebellar signs. (ucl.ac.uk)
- An apparent increase in the number of persons with tremor, myoclonus, and parkinsonism between 4 mo and 1 y is reflective of detection of these movement disorders in persons who were initially flaccid/immobile, nonambulatory, or too functionally impaired to assess. (cdc.gov)
Dystonia19
- Myoclonus-dystonia is a movement disorder that typically affects the neck, torso, and arms. (medlineplus.gov)
- About half of individuals with myoclonus-dystonia develop dystonia, which is involuntary tensing of various muscles that causes unusual positioning. (medlineplus.gov)
- In myoclonus-dystonia, dystonia often affects one or both hands, causing writer's cramp, or the neck, causing the head to turn (torticollis). (medlineplus.gov)
- People with myoclonus-dystonia often develop psychological disorders such as depression , anxiety, panic attacks, and obsessive-compulsive disorder (OCD). (medlineplus.gov)
- The prevalence of myoclonus-dystonia in Europe is estimated to be 1 in 500,000 individuals. (medlineplus.gov)
- Mutations in the SGCE gene cause 30 to 50 percent of cases of myoclonus-dystonia. (medlineplus.gov)
- SGCE gene mutations that cause myoclonus-dystonia result in a shortage (deficiency) of functional ε-sarcoglycan protein. (medlineplus.gov)
- Mutations in multiple other genes are associated with myoclonus-dystonia. (medlineplus.gov)
- Some people with myoclonus-dystonia do not have an identified mutation in any of the known associated genes. (medlineplus.gov)
- When caused by SGCE gene mutations, myoclonus-dystonia occurs only when the mutation is inherited from a person's father. (medlineplus.gov)
- Because only the paternal copy of the SGCE gene is active, myoclonus-dystonia occurs when mutations affect the paternal copy of the SGCE gene. (medlineplus.gov)
- Rarely, individuals who inherit an SGCE gene mutation from their mothers will develop features of myoclonus-dystonia. (medlineplus.gov)
- Other genes associated with myoclonus-dystonia are not imprinted, and mutations that cause the condition can be inherited from either parent. (medlineplus.gov)
- SGCE missense mutations that cause myoclonus-dystonia syndrome impair epsilon-sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA. (medlineplus.gov)
- OBJECTIVE: To identify the cause of autosomal dominant tremulous myoclonus-dystonia in a UK kindred with affected individuals in three generations. (ucl.ac.uk)
- METHODS: Known genetic causes of myoclonus-dystonia were excluded. (ucl.ac.uk)
- We combined clinical and electrophysiological phenotyping with whole-exome sequencing and Sanger sequencing to identify candidate causal variants in a family with tremulous myoclonus-dystonia. (ucl.ac.uk)
- Segregation, absence of the variant in the normal population and in silico prediction of a deleterious effect together with animal models compatible with the clinical phenotype are all in line with KCNN2 mutations being a plausible cause underlying myoclonus-dystonia. (ucl.ac.uk)
- Myoclonus dystonia, a genetic form of dystonia, is characterized by rapid jerking movements alone or in combination with the sustained muscular contractions and postures of dystonia. (dxiled.com)
Myoclonic3
- There are no drugs specifically designed to treat myoclonus, but doctors have borrowed from other disease treatment arsenals to relieve myoclonic symptoms. (sparrow.org)
- These include subcortical myoclonus, myoclonic status epilepticus (MSE), and Lance-Adams syndrome. (medscape.com)
- In idiopathic myoclonus, the myoclonic movement appears spontaneously, without being associated with other symptoms or illnesses, being able to interfere in the daily activities of the persons. (salutio.org)
Forms of myoclonus2
- These forms of myoclonus occur in healthy people and rarely present a problem. (sparrow.org)
- Botox injections can help treat different forms of myoclonus, especially when only part of the body is affected. (salutio.org)
Symptomatic4
- Symptomatic myoclonus occurs as a result of an underlying medical condition. (sparrow.org)
- Symptomatic myoclonus occurs because of the underlying medical condition, which may include head or spinal cord injury, infection, liver failure, drug poisoning. (gleneaglesglobalhospitals.com)
- IMSEAR at SEARO: A case of symptomatic palatal myoclonus. (who.int)
- Also known as symptomatic myoclonus, it usually occurs as a result of another illness or medical condition, such as head or spinal cord injury, infection, kidney or liver failure, Gaucher disease, poisoning, prolonged oxygen deprivation, drug reaction, autoimmune and metabolic diseases. (salutio.org)
Jerks4
- Individuals with this condition experience quick, involuntary muscle jerks or twitches (myoclonus). (medlineplus.gov)
- Hiccups are a form of myoclonus, as are the sudden jerks, or "sleep starts," you may feel just before falling asleep. (sparrow.org)
- Myoclonus is more commonly known as "Muscle Jerks. (broadviewhealthcentre.com)
- Myoclonus refers to sudden muscle jerks. (medicalnewstoday.com)
Epileptic disorder2
- This type of myoclonus occurs as part of an epileptic disorder. (sparrow.org)
- This type of myoclonus arises due to an epileptic disorder, where convulsions occur that cause rapid movements in both arms and legs. (salutio.org)
Ataxia4
- Opsoclonus-myoclonus-(ataxia) syndrome (OMS), or dancing-eyes syndrome, is a rare encephalopathy, seen mainly in infancy with an estimated incidence per year of 0.18 per million total population (Pang et al. (springeropen.com)
- 2010 ). OMS is characterized by jerking conjugated bulbar movements, ataxia with myoclonus and psychiatric symptoms such as behavioral change. (springeropen.com)
- ObjectiveTo identify neuronal surface antibodies in opsoclonus myoclonus ataxia syndrome (OMAS) using contemporary antigen discovery methodology.MethodsOMAS patient serum immunoglobulin G immunohistochemistry using age-equivalent rat cerebellar tissue was followed by immunoprecipitation, gel electrophoresis, and mass spectrometry. (ox.ac.uk)
- Acute cerebellar ataxia, acute cerebellitis, and opsoclonus- myoclonus syndrome. (bvsalud.org)
Easing myoclonus symptoms1
- Most of the time, however, the underlying cause can't be cured or eliminated, so treatment is aimed at easing myoclonus symptoms, especially when they're disabling. (sparrow.org)
Syndrome5
- A 22-month-old girl at onset of opsoclonus-myoclonus syndrome (OMS) was followed for 8 years. (springeropen.com)
- The clinical picture led to the diagnosis of opsoclonus-myoclonus syndrome. (springeropen.com)
- Lance-Adams syndrome is "classically characterized by action myoclonus" after a patient awakens from anoxic injury. (medscape.com)
- Do Vaccines Cause Opsoclonus Myoclonus Syndrome? (vaccinesafety.edu)
- BARINGER JR, SWEENEY VP, WINKLER GF: An acute syndrome of ocular oscillations and truncal myoclonus. (businessrefinery.com)
Type of myoclonus1
- This type of myoclonus occurs in normal, healthy people and rarely needs treatment. (sparrow.org)
Form of myoclonus1
- They are hypothesized to be a form of myoclonus, as are the sudden movements that occur when the person is falling asleep. (salutio.org)
Types of myoclonus3
- Doctors often separate the types of myoclonus based on their causes, which helps determine treatment. (sparrow.org)
- Types of myoclonus include the following categories. (sparrow.org)
- Your doctor may prescribe onabotulinumtoxinA (Botox) injections for treating different types of myoclonus. (gleneaglesglobalhospitals.com)
Cause of myoclonus3
- If the cause of myoclonus is unknown or can't be specifically treated, then treatment focuses on reducing the effects of myoclonus on your quality of life. (sparrow.org)
- Your doctor would order for genetic testing, blood or urine analysis to identify the possible cause of myoclonus. (gleneaglesglobalhospitals.com)
- If the cause of myoclonus is identified as a tumor or lesion in the brain or spinal cord, then your doctor would recommend for surgery. (gleneaglesglobalhospitals.com)
Symptoms of myoclonus2
- What are some of the symptoms of myoclonus? (broadviewhealthcentre.com)
- Furthermore, in case of epileptic myoclonus, the neurologist prescribes the use of anticonvulsants to reduce the symptoms of myoclonus. (salutio.org)
Essential myoclonus4
- Essential myoclonus occurs on its own, usually without other symptoms and without being related to any underlying illness. (sparrow.org)
- The cause of essential myoclonus is often unexplained (idiopathic) or, in some cases, hereditary. (sparrow.org)
- Essential myoclonus usually occurs without any symptoms and any related underlying cause. (gleneaglesglobalhospitals.com)
- [ 30 ] Benign neonatal essential myoclonus is typically noted in older infants and generally not during sleep, which is an important distinction. (medscape.com)
Cortical1
- Electrophysiological assessment indicated a cortical origin for the myoclonus in every case. (cun.es)
Syndromes1
- Past studies have discussed several "clinical syndromes of postanoxic myoclonus," report the investigators. (medscape.com)
Diagnosis4
- If your myoclonus symptoms become frequent and persistent, talk to your doctor for further evaluation and proper diagnosis and treatment. (sparrow.org)
- Myoclonus is considered as a symptom of other condition and not a diagnosis of a disease. (gleneaglesglobalhospitals.com)
- If the symptoms associated with myoclonus are frequent and persistent, then you must call your doctor for further evaluation and diagnosis followed by appropriate treatment. (gleneaglesglobalhospitals.com)
- This 80-year-old right-handed male presented with leg jerking and a diagnosis of myoclonus. (tremorjournal.org)
Disorders2
- Pathologic myoclonus may result from various disorders and drugs side effects. (gleneaglesglobalhospitals.com)
- Two subjects had similar movement disorders characterized by myoclonus. (cdc.gov)
Involuntary4
- Myoclonus refers to a quick, involuntary muscle jerk. (sparrow.org)
- Myoclonus is a term used to describe episodes of sudden, involuntary muscle jerking or twitching that can affect part of the body or the entire body. (medlineplus.gov)
- Myoclonus are brief, rapid, involuntary and sudden movements, similar to a shock, which consists of simple or repetitive muscular discharges. (salutio.org)
- In general, people with myoclonus describe a type of sudden, brief and involuntary muscle spasm, similar to a shock and that can vary both in intensity and frequency, and can occur in one or several parts of the body. (salutio.org)
Pathologic1
- Scher MS. Pathologic myoclonus of the newborn: electrographic and clinical correlations. (medscape.com)
Parkinson's Disease1
- In addition, there are other conditions related to the central nervous system that can also cause secondary myoclonus, such as the case of stroke, brain tumor, Huntington's disease, Creutzfeldt-Jakob disease, Alzheimer's and Parkinson's disease, corticobasal degeneration and frontotemporal dementia. (salutio.org)
Secondary1
- The secondary outcome of discharge with functionally favorable outcomes occurred in 17% of the study population, including all of the pattern 2 myoclonus survivors. (medscape.com)
Disorder1
- In some adults, myoclonus improves with alcohol consumption, which can lead to affected individuals self-medicating and developing alcohol use disorder . (medlineplus.gov)
Brain4
- This procedure records the electrical activity of your brain and may help determine where in your brain the myoclonus originates. (sparrow.org)
- An MRI scan may be used to check for structural problems or tumors inside your brain or spinal cord, which may cause your myoclonus symptoms. (sparrow.org)
- this helps record the electrical activity of your brain and helps in determining the origin of myoclonus. (gleneaglesglobalhospitals.com)
- Your doctor suggests MRI scan for detecting the involved structural problems or tumors inside the brain or spinal cord, which can be the cause for myoclonus. (gleneaglesglobalhospitals.com)
Contractions3
- Indica strains work well when you want to relieve twitching and contractions from myoclonus at night so that you can ease the muscle twitching and fall asleep faster. (marijuanadoctors.com)
- THC can be beneficial when you need a burst of energy and creativity while keeping your myoclonus contractions under control. (marijuanadoctors.com)
- When your muscle or muscles produce shock-like contractions, then the condition is termed as myoclonus. (gleneaglesglobalhospitals.com)
Multifocal1
- Electroencephalography (EEG) can distinguish phenotypes of postanoxic multifocal myoclonus (PAMM), a condition that may develop soon after cardiac arrest - but only one EEG pattern is associated with "functionally favorable" survival, according to new research. (medscape.com)
Spinal cord1
- We report two cases that may represent the isolated motor component of RLS, misdiagnosed as myoclonus by referring neurologists, in the setting of spinal cord pathology. (tremorjournal.org)
Physiological1
- In general, myoclonus is physiological and is not a cause for concern. (salutio.org)
Symptom1
- While not a disease on its own, myoclonus is a symptom that can cause limitations on normal activities. (marijuanadoctors.com)
Benign7
- Benign neonatal sleep myoclonus: clinical features and video-polygraphic recordings. (medscape.com)
- Benign neonatal sleep myoclonus: a review of the literature. (medscape.com)
- Benign neonatal sleep myoclonus: an under-recognized, non-epileptic condition. (medscape.com)
- Paro-Panjan D, Neubauer D. Benign neonatal sleep myoclonus: experience from the study of 38 infants. (medscape.com)
- Benign neonatal sleep myoclonus: Our experience of 15 Japanese cases. (medscape.com)
- Cohen R, Shuper A, Straussberg R. Familial benign neonatal sleep myoclonus. (medscape.com)
- Benign neonatal sleep myoclonus: case report and follow-up of four members of an affected family. (medscape.com)
Spasms1
- Myoclonus: what is it, why do these spasms arise and how are they treated? (salutio.org)
Hiccups1
- You may have experienced myoclonus - or seen someone else experience it - in the form of hiccups, for example, or "sleep starts" that are the sudden jolt just as you drift off to sleep. (broadviewhealthcentre.com)
Neuronal1
- The serotonin hypothesis of myoclonus from the perspective of neuronal rhythmicity. (medscape.com)
Clinical features1
- Clinical features may also include proximal myoclonus and mild progression with aging. (nih.gov)
Frequent1
- It is almost always not a cause for alarm but can certainly be frustrating - especially if the myoclonus is an ongoing and frequent situation. (broadviewhealthcentre.com)
Muscles4
- Myoclonus - A condition of abnormal contraction of muscles or portions of muscles. (en-academic.com)
- myoclonus - [ˌmʌɪə(ʊ) kləʊnəs] noun Medicine spasmodic jerky contraction of groups of muscles. (en-academic.com)
- Myoclonus may occur when abnormal electrical impulse generated by the central nervous system affects a muscle or group of muscles. (gleneaglesglobalhospitals.com)
- This procedure measures the electrical discharges produced in the muscles and helps in establishing the pattern of myoclonus. (gleneaglesglobalhospitals.com)
Interfere1
- In very serious cases, myoclonus could interfere with eating, talking or walking. (salutio.org)