A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The circulation of blood through the CORONARY VESSELS of the HEART.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
The hollow, muscular organ that maintains the circulation of the blood.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.
The veins and arteries of the HEART.
Elements of limited time intervals, contributing to particular results or situations.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Contractile activity of the MYOCARDIUM.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
A technique in which tissue is rendered resistant to the deleterious effects of prolonged ISCHEMIA and REPERFUSION by prior exposure to brief, repeated periods of vascular occlusion. (Am J Physiol 1995 May;268(5 Pt 2):H2063-7, Abstract)
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A tissue or organ remaining at physiological temperature during decreased BLOOD perfusion or in the absence of blood supply. During ORGAN TRANSPLANTATION it begins when the organ reaches physiological temperature before the completion of SURGICAL ANASTOMOSIS and ends with reestablishment of the BLOOD CIRCULATION through the tissue.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
Treatment process involving the injection of fluid into an organ or tissue.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
Drugs used to cause dilation of the blood vessels.
Pressure, burning, or numbness in the chest.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
A method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (EXERCISE TEST) or pharmacologic stress.
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
The application of repeated, brief periods of vascular occlusion at the onset of REPERFUSION to reduce REPERFUSION INJURY that follows a prolonged ischemic event. The techniques are similar to ISCHEMIC PRECONDITIONING but the time of application is after the ischemic event instead of before.
A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys.
Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
Disease having a short and relatively severe course.
The mitochondria of the myocardium.
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
Narrowing or constriction of a coronary artery.
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Genetically developed small pigs for use in biomedical research. There are several strains - Yucatan miniature, Sinclair miniature, and Minnesota miniature.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Examinations used to diagnose and treat heart conditions.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
The act of constricting.
A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.
Malformations of CORONARY VESSELS, either arteries or veins. Included are anomalous origins of coronary arteries; ARTERIOVENOUS FISTULA; CORONARY ANEURYSM; MYOCARDIAL BRIDGING; and others.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.
Spasm of the large- or medium-sized coronary arteries.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
ANGINA PECTORIS or angina-like chest pain with a normal coronary arteriogram and positive EXERCISE TEST. The cause of the syndrome is unknown. While its recognition is of clinical importance, its prognosis is excellent. (Braunwald, Heart Disease, 4th ed, p1346; Jablonski Dictionary of Syndromes & Eponymic Diseases, 2d ed). It is different from METABOLIC SYNDROME X, a syndrome characterized by INSULIN RESISTANCE and HYPERINSULINEMIA, that has increased risk for cardiovascular disease.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders and has been added to cardioplegic solutions. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1996)
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
Organic compounds containing both the hydroxyl and carboxyl radicals.
The innermost layer of the heart, comprised of endothelial cells.
The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.
Diseases that do not exhibit symptoms.
An isoenzyme of creatine kinase found in the CARDIAC MUSCLE.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
10-carbon saturated monocarboxylic acids.
An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
Compounds based on N-phenylacetamide, that are similar in structure to 2-PHENYLACETAMIDES. They are precursors of many other compounds. They were formerly used as ANALGESICS and ANTIPYRETICS, but often caused lethal METHEMOGLOBINEMIA.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)
The flow of BLOOD through or around an organ or region of the body.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
Relatively complete absence of oxygen in one or more tissues.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
The span of viability of a tissue or an organ.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The dialdehyde of malonic acid.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
Operative procedures for the treatment of vascular disorders.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
Tomography using single-photon emitting RADIONUCLIDES to create images that are captured in times corresponding to various points in the cardiac cycle.
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
Recording of the moment-to-moment electromotive forces of the heart on a plane of the body surface delineated as a vector function of time.
The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
The chemical reactions involved in the production and utilization of various forms of energy in cells.
Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Solutions which, upon administration, will temporarily arrest cardiac activity. They are used in the performance of heart surgery.
Application of a ligature to tie a vessel or strangulate a part.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H3 receptors were first recognized as inhibitory autoreceptors on histamine-containing nerve terminals and have since been shown to regulate the release of several neurotransmitters in the central and peripheral nervous systems. (From Biochem Soc Trans 1992 Feb;20(1):122-5)
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Interventions to provide care prior to, during, and immediately after surgery.
Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Obstruction of the flow in the SPLANCHNIC CIRCULATION by ATHEROSCLEROSIS; EMBOLISM; THROMBOSIS; STENOSIS; TRAUMA; and compression or intrinsic pressure from adjacent tumors. Rare causes are drugs, intestinal parasites, and vascular immunoinflammatory diseases such as PERIARTERITIS NODOSA and THROMBOANGIITIS OBLITERANS. (From Juergens et al., Peripheral Vascular Diseases, 5th ed, pp295-6)
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A species of SWINE, in the family Suidae, comprising a number of subspecies including the domestic pig Sus scrofa domestica.
A malformation that is characterized by a muscle bridge over a segment of the CORONARY ARTERIES. Systolic contractions of the muscle bridge can lead to narrowing of coronary artery; coronary compression; MYOCARDIAL ISCHEMIA; MYOCARDIAL INFARCTION; and SUDDEN CARDIAC DEATH.
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
The constant checking on the state or condition of a patient during the course of a surgical operation (e.g., checking of vital signs).
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
The period during a surgical operation.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Delivery of drugs into an artery.
An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
A condition of decreased oxygen content at the cellular level.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.
The process by which chemical compounds provide protection to cells against harmful agents.
A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. The measurement is commonly used to verify borderline stenosis of CORONARY ARTERIES.
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
VASCULAR DISEASES that are associated with DIABETES MELLITUS.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
One of the minor protein components of skeletal muscle. Its function is to serve as the calcium-binding component in the troponin-tropomyosin B-actin-myosin complex by conferring calcium sensitivity to the cross-linked actin and myosin filaments.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
The inferior part of the lower extremity between the KNEE and the ANKLE.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.

AMP-activated protein kinase phosphorylation of endothelial NO synthase. (1/6685)

The AMP-activated protein kinase (AMPK) in rat skeletal and cardiac muscle is activated by vigorous exercise and ischaemic stress. Under these conditions AMPK phosphorylates and inhibits acetyl-coenzyme A carboxylase causing increased oxidation of fatty acids. Here we show that AMPK co-immunoprecipitates with cardiac endothelial NO synthase (eNOS) and phosphorylates Ser-1177 in the presence of Ca2+-calmodulin (CaM) to activate eNOS both in vitro and during ischaemia in rat hearts. In the absence of Ca2+-calmodulin, AMPK also phosphorylates eNOS at Thr-495 in the CaM-binding sequence, resulting in inhibition of eNOS activity but Thr-495 phosphorylation is unchanged during ischaemia. Phosphorylation of eNOS by the AMPK in endothelial cells and myocytes provides a further regulatory link between metabolic stress and cardiovascular function.  (+info)

Differential regulation of Bcl-2, AP-1 and NF-kappaB on cardiomyocyte apoptosis during myocardial ischemic stress adaptation. (2/6685)

Acute ischemia followed by prolonged reperfusion has been shown to induce cardiomyocyte apoptosis. In this report, we demonstrate that myocardial adaptation to ischemia induced by repeated cyclic episodes of short-term ischemia each followed by another short duration of reperfusion reduced cardiomyocyte apoptosis and DNA fragmentation. This was associated with the induction of the expression of Bcl-2 mRNA and translocation and activation of NF-kappaB. Another transcription factor, AP-1, remained unaffected by repeated ischemia and reperfusion, but exhibited significant upregulation by a single episode of 30 min ischemia followed by 2 h of reperfusion. This activation of AP-1 was inhibited by a scavenger of oxygen free radicals, DMTU. Thirty minutes ischemia and 120 min reperfusion downregulated the induction of the expression of Bcl-2 mRNA, but moderately activated NF-kappaB binding activity. This was associated with an increased number of apoptotic cells and DNA fragmentation in cardiomyocytes which were attenuated by DMTU. The results of this study indicate that Bcl-2, AP-1 and NF-kappaB differentially regulate cardiomyocyte apoptosis mediated by acute ischemia and prolonged reperfusion.  (+info)

Chlamydia pneumoniae antibodies are associated with an atherogenic lipid profile. (3/6685)

OBJECTIVE: To determine, within a representative population group of men and women, whether alteration of the lipid profile might underlie the reported association between Chlamydia pneumoniae and ischaemic heart disease. DESIGN AND SETTING: Cross sectional survey in an area with a high incidence of ischaemic heart disease. SUBJECTS: 400 randomly selected participants in the World Health Organisation MONICA project's third population survey in Northern Ireland. MAIN OUTCOME MEASURES: Stored sera were examined by microimmunofluorescence for IgG antibodies to C pneumoniae at a dilution of 1 in 64. Mean total and high density lipoprotein (HDL) cholesterol were compared between seropositive and seronegative individuals with adjustment for age, measures of socioeconomic status, smoking habit, alcohol consumption, body mass index, and the season during which blood had been taken. RESULTS: In seropositive men, adjusted mean serum total cholesterol and HDL cholesterol were 0.5 mmol/l (9.2%) higher and 0.11 mmol/l (9.3%) lower, respectively, than in seronegative men. Differences in women did not achieve statistical significance, but both total cholesterol and HDL cholesterol were higher (3.6% and 5.8%, respectively) in seropositive than in seronegative individuals. CONCLUSIONS: There is serological evidence that C pneumoniae infection is associated with an atherogenic lipid profile in men. Altered lipid levels may underlie the association between C pneumoniae and ischaemic heart disease.  (+info)

Cytomegalovirus seropositivity and incident ischaemic heart disease in the Caerphilly prospective heart disease study. (4/6685)

OBJECTIVE: To assess the role of cytomegalovirus (CMV) infection in primary ischaemic heart disease. METHODS: Plasma specimens collected during 1979-83 from men in Caerphilly, south Wales, were analysed for IgG antibodies to CMV by enzyme linked immunosorbent assay and latex tests. Incident ischaemic heart disease events were ascertained after five and 10 years from death certificates, hospital records, and ECG changes; 195 incident ischaemic heart disease cases were compared with 216 controls of a similar age drawn from the rest of the cohort. RESULTS: 164 cases (84%) and 180 controls (83%) were seropositive for CMV. Optical density, an indicator of CMV antibody titre, was similar for cases and controls. Among controls, seropositivity was not associated with age, socioeconomic status currently or in childhood, smoking, height, body mass index, blood pressure, total cholesterol, fibrinogen, plasma viscosity, or leucocyte count. The unadjusted odds ratio relating CMV seropositivity to incident ischaemic heart disease was 1.06 (95% confidence interval 0.63 to 1.79) and was little changed (1.11, 0.63 to 1.97) after adjustment for age, smoking, body mass index, systolic blood pressure, total cholesterol, and socioeconomic status currently and in childhood. CONCLUSIONS: CMV infection is unlikely to be a strong risk factor for development of myocardial infarction in middle aged men.  (+info)

Reactive oxygen species play an important role in the activation of heat shock factor 1 in ischemic-reperfused heart. (5/6685)

BACKGROUND: The myocardial protective role of heat shock protein (HSP) has been demonstrated. Recently, we reported that ischemia/reperfusion induced a significant activation of heat shock factor (HSF) 1 and an accumulation of mRNA for HSP70 and HSP90. We examined the role of reactive oxygen species (ROSs) in the induction of stress response in the ischemic-reperfused heart. METHODS AND RESULTS: Rat hearts were isolated and perfused with Krebs-Henseleit buffer by the Langendorff method. Whole-cell extracts were prepared for gel mobility shift assay using oligonucleotides containing the heat shock element. Induction of mRNA for HSP70 and HSP90 was examined by Northern blot analysis. Repetitive ischemia/reperfusion, which causes recurrent bursts of free radical generation, resulted in burst activation of HSF1, and this burst activation was significantly reduced with either allopurinol 1 mmol/L (an inhibitor of xanthine oxidase) or catalase 2x10(5) U/L (a scavenger of H2O2). Significant activation of HSF1 was observed on perfusion with buffer containing H2O2 150 micromol/L or xanthine 1 mmol/L plus xanthine oxidase 5 U/L. The accumulation of mRNA for HSP70 or HSP90 after repetitive ischemia/reperfusion was reduced with either allopurinol or catalase. CONCLUSIONS: Our findings demonstrate that ROSs play an important role in the activation of HSF1 and the accumulation of mRNA for HSP70 and HSP90 in the ischemic-reperfused heart.  (+info)

Bradykinin promotes ischemic norepinephrine release in guinea pig and human hearts. (6/6685)

We previously reported that bradykinin (BK; 1-1000 nM) facilitates norepinephrine (NE) release from cardiac sympathetic nerves. Because BK production increases in myocardial ischemia, endogenous BK could foster NE release and associated arrhythmias. We tested this hypothesis in guinea pig and human myocardial ischemia models. BK administration (100 nM) markedly enhanced exocytotic and carrier-mediated NE overflow from guinea pig hearts subjected to 10- and 20-min ischemia/reperfusion, respectively. Ventricular fibrillation invariably occurred after 20-min global ischemia; BK prolonged its duration 3-fold. The BK B2 receptor antagonist HOE140 (30 nM) blocked the effects of BK, whereas the B1 receptor antagonist des-Arg9-Leu8-BK (1 microM; i.e., 2.5 x pA2) did not. When serine proteinase inhibitors (500 KIU/ml aprotinin and 100 microg/ml soybean trypsin inhibitor) were used to prevent the formation of endogenous BK, NE overflow and reperfusion arrhythmias were diminished. In contrast, when kininase I and II inhibitors (DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid and enalaprilat, each 1 microM) were used to prevent the degradation of endogenous BK, NE overflow and reperfusion arrhythmias were enhanced. B2 receptor blockade abolished these effects but was ineffective if kininases were not inhibited. B2 receptor stimulation, by either exogenous or endogenous BK, also markedly enhanced carrier-mediated NE release in the human myocardial ischemia model; conversely, inhibition of BK biosynthesis diminished ischemic NE release. Because atherosclerotic heart disease impairs endothelial BK production, in myocardial ischemia BK could accumulate at sympathetic nerve endings, thus augmenting exocytotic and carrier-mediated NE release and favoring coronary vasoconstriction and arrhythmias.  (+info)

Labeling of the internal pool of GP IIb-IIIa in platelets by c7E3 Fab fragments (abciximab): flow and endocytic mechanisms contribute to the transport. (7/6685)

Abciximab is a new antiplatelet therapeutic in ischemic cardiovascular disease. The drug, chimeric Fab fragments of a murine monoclonal antibody (MoAb) (c7E3), blocks GP IIb-IIIa function. However, its capacity to reach all receptor pools in platelets is unknown. Electron microscopy and immunogold labeling were used to localize abciximab in platelets of patients receiving the drug for up to 24 hours. Studies on frozen-thin sections showed that c7E3 Fab, in addition to the surface pool, also labeled the surface-connected canalicular system (SCCS) and alpha-granules. Analysis of gold particle distribution showed that intraplatelet labeling was not accumulative and in equilibrium with the surface pool. After short-term incubations of platelets with c7E3 Fab in vitro, gold particles were often seen in lines within thin elements of the SCCS, some of which appeared in contact with alpha-granules. Little labeling was associated with Glanzmann's thrombasthenia platelets, confirming that the channels contained bound and not free c7E3 Fab. Endocytosis of abciximab in clathrin-containing vesicles was visualized by double staining and constitutes an alternative mechanism of transport. The remaining free pool of GP IIb-IIIa was evaluated with the MoAb AP-2; flow cytometry showed it to be about 9% on the surface of nonstimulated platelets but 33% on thrombin-activated platelets. The ability of drugs to block all pools of GP IIb-IIIa and then to be associated with secretion-dependent residual aggregation must be considered when evaluating their efficiency in a clinical context.  (+info)

An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia. (8/6685)

Cellular ischemia results in activation of a number of kinases, including p38 mitogen-activated protein kinase (MAPK); however, it is not yet clear whether p38 MAPK activation plays a role in cellular damage or is part of a protective response against ischemia. We have developed a model to study ischemia in cultured neonatal rat cardiac myocytes. In this model, two distinct phases of p38 MAPK activation were observed during ischemia. The first phase began within 10 min and lasted less than 1 h, and the second began after 2 h and lasted throughout the ischemic period. Similar to previous studies using in vivo models, the nonspecific activator of p38 MAPK and c-Jun NH2-terminal kinase, anisomycin, protected cardiac myocytes from ischemic injury, decreasing the release of cytosolic lactate dehydrogenase by approximately 25%. We demonstrated, however, that a selective inhibitor of p38 MAPK, SB 203580, also protected cardiac myocytes against extended ischemia in a dose-dependent manner. The protective effect was seen even when the inhibitor was present during only the second, sustained phase of p38 MAPK activation. We found that ischemia induced apoptosis in neonatal rat cardiac myocytes and that SB 203580 reduced activation of caspase-3, a key event in apoptosis. These results suggest that p38 MAPK induces apoptosis during ischemia in cardiac myocytes and that selective inhibition of p38 MAPK could be developed as a potential therapy for ischemic heart disease.  (+info)

Myocardial ischemia can be caused by a variety of factors, including coronary artery disease, high blood pressure, diabetes, and smoking. It can also be triggered by physical exertion or stress.

There are several types of myocardial ischemia, including:

1. Stable angina: This is the most common type of myocardial ischemia, and it is characterized by a predictable pattern of chest pain that occurs during physical activity or emotional stress.
2. Unstable angina: This is a more severe type of myocardial ischemia that can occur without any identifiable trigger, and can be accompanied by other symptoms such as shortness of breath or vomiting.
3. Acute coronary syndrome (ACS): This is a condition that includes both stable angina and unstable angina, and it is characterized by a sudden reduction in blood flow to the heart muscle.
4. Heart attack (myocardial infarction): This is a type of myocardial ischemia that occurs when the blood flow to the heart muscle is completely blocked, resulting in damage or death of the cardiac tissue.

Myocardial ischemia can be diagnosed through a variety of tests, including electrocardiograms (ECGs), stress tests, and imaging studies such as echocardiography or cardiac magnetic resonance imaging (MRI). Treatment options for myocardial ischemia include medications such as nitrates, beta blockers, and calcium channel blockers, as well as lifestyle changes such as quitting smoking, losing weight, and exercising regularly. In severe cases, surgical procedures such as coronary artery bypass grafting or angioplasty may be necessary.

There are several types of ischemia, including:

1. Myocardial ischemia: Reduced blood flow to the heart muscle, which can lead to chest pain or a heart attack.
2. Cerebral ischemia: Reduced blood flow to the brain, which can lead to stroke or cognitive impairment.
3. Peripheral arterial ischemia: Reduced blood flow to the legs and arms.
4. Renal ischemia: Reduced blood flow to the kidneys.
5. Hepatic ischemia: Reduced blood flow to the liver.

Ischemia can be diagnosed through a variety of tests, including electrocardiograms (ECGs), stress tests, and imaging studies such as CT or MRI scans. Treatment for ischemia depends on the underlying cause and may include medications, lifestyle changes, or surgical interventions.

The term ischemia refers to the reduction of blood flow, and it is often used interchangeably with the term stroke. However, not all strokes are caused by ischemia, as some can be caused by other factors such as bleeding in the brain. Ischemic stroke accounts for about 87% of all strokes.

There are different types of brain ischemia, including:

1. Cerebral ischemia: This refers to the reduction of blood flow to the cerebrum, which is the largest part of the brain and responsible for higher cognitive functions such as thought, emotion, and voluntary movement.
2. Cerebellar ischemia: This refers to the reduction of blood flow to the cerebellum, which is responsible for coordinating and regulating movement, balance, and posture.
3. Brainstem ischemia: This refers to the reduction of blood flow to the brainstem, which is responsible for controlling many of the body's automatic functions such as breathing, heart rate, and blood pressure.
4. Territorial ischemia: This refers to the reduction of blood flow to a specific area of the brain, often caused by a blockage in a blood vessel.
5. Global ischemia: This refers to the reduction of blood flow to the entire brain, which can be caused by a cardiac arrest or other systemic conditions.

The symptoms of brain ischemia can vary depending on the location and severity of the condition, but may include:

1. Weakness or paralysis of the face, arm, or leg on one side of the body
2. Difficulty speaking or understanding speech
3. Sudden vision loss or double vision
4. Dizziness or loss of balance
5. Confusion or difficulty with memory
6. Seizures
7. Slurred speech or inability to speak
8. Numbness or tingling sensations in the face, arm, or leg
9. Vision changes, such as blurred vision or loss of peripheral vision
10. Difficulty with coordination and balance.

It is important to seek medical attention immediately if you experience any of these symptoms, as brain ischemia can cause permanent damage or death if left untreated.

MRI can occur in various cardiovascular conditions, such as myocardial infarction (heart attack), cardiac arrest, and cardiac surgery. The severity of MRI can range from mild to severe, depending on the extent and duration of the ischemic event.

The pathophysiology of MRI involves a complex interplay of various cellular and molecular mechanisms. During ischemia, the heart muscle cells undergo changes in energy metabolism, electrolyte balance, and cell membrane function. When blood flow is restored, these changes can lead to an influx of calcium ions into the cells, activation of enzymes, and production of reactive oxygen species (ROS), which can damage the cells and their membranes.

The clinical presentation of MRI can vary depending on the severity of the injury. Some patients may experience chest pain, shortness of breath, and fatigue. Others may have more severe symptoms, such as cardiogenic shock or ventricular arrhythmias. The diagnosis of MRI is based on a combination of clinical findings, electrocardiography (ECG), echocardiography, and cardiac biomarkers.

The treatment of MRI is focused on addressing the underlying cause of the injury and managing its symptoms. For example, in patients with myocardial infarction, thrombolysis or percutaneous coronary intervention may be used to restore blood flow to the affected area. In patients with cardiac arrest, cardiopulmonary resuscitation (CPR) and other life-saving interventions may be necessary.

Prevention of MRI is crucial in reducing its incidence and severity. This involves aggressive risk factor management, such as controlling hypertension, diabetes, and dyslipidemia, as well as smoking cessation and stress reduction. Additionally, patients with a history of MI should adhere to their medication regimen, which may include beta blockers, ACE inhibitors or ARBs, statins, and aspirin.

In conclusion, myocardial injury with ST-segment elevation (MRI) is a life-threatening condition that requires prompt recognition and treatment. While the clinical presentation can vary depending on the severity of the injury, early diagnosis and management are crucial in reducing morbidity and mortality. Prevention through aggressive risk factor management and adherence to medication regimens is also essential in preventing MRI.

Coronary disease is often caused by a combination of genetic and lifestyle factors, such as high blood pressure, high cholesterol levels, smoking, obesity, and a lack of physical activity. It can also be triggered by other medical conditions, such as diabetes and kidney disease.

The symptoms of coronary disease can vary depending on the severity of the condition, but may include:

* Chest pain or discomfort (angina)
* Shortness of breath
* Fatigue
* Swelling of the legs and feet
* Pain in the arms and back

Coronary disease is typically diagnosed through a combination of physical examination, medical history, and diagnostic tests such as electrocardiograms (ECGs), stress tests, and cardiac imaging. Treatment for coronary disease may include lifestyle changes, medications to control symptoms, and surgical procedures such as angioplasty or bypass surgery to improve blood flow to the heart.

Preventative measures for coronary disease include:

* Maintaining a healthy diet and exercise routine
* Quitting smoking and limiting alcohol consumption
* Managing high blood pressure, high cholesterol levels, and other underlying medical conditions
* Reducing stress through relaxation techniques or therapy.

Reperfusion injury can cause inflammation, cell death, and impaired function in the affected tissue or organ. The severity of reperfusion injury can vary depending on the duration and severity of the initial ischemic event, as well as the promptness and effectiveness of treatment to restore blood flow.

Reperfusion injury can be a complicating factor in various medical conditions, including:

1. Myocardial infarction (heart attack): Reperfusion injury can occur when blood flow is restored to the heart muscle after a heart attack, leading to inflammation and cell death.
2. Stroke: Reperfusion injury can occur when blood flow is restored to the brain after an ischemic stroke, leading to inflammation and damage to brain tissue.
3. Organ transplantation: Reperfusion injury can occur when a transplanted organ is subjected to ischemia during harvesting or preservation, and then reperfused with blood.
4. Peripheral arterial disease: Reperfusion injury can occur when blood flow is restored to a previously occluded peripheral artery, leading to inflammation and damage to the affected tissue.

Treatment of reperfusion injury often involves medications to reduce inflammation and oxidative stress, as well as supportive care to manage symptoms and prevent further complications. In some cases, experimental therapies such as stem cell transplantation or gene therapy may be used to promote tissue repair and regeneration.

There are different types of myocardial infarctions, including:

1. ST-segment elevation myocardial infarction (STEMI): This is the most severe type of heart attack, where a large area of the heart muscle is damaged. It is characterized by a specific pattern on an electrocardiogram (ECG) called the ST segment.
2. Non-ST-segment elevation myocardial infarction (NSTEMI): This type of heart attack is less severe than STEMI, and the damage to the heart muscle may not be as extensive. It is characterized by a smaller area of damage or a different pattern on an ECG.
3. Incomplete myocardial infarction: This type of heart attack is when there is some damage to the heart muscle but not a complete blockage of blood flow.
4. Collateral circulation myocardial infarction: This type of heart attack occurs when there are existing collateral vessels that bypass the blocked coronary artery, which reduces the amount of damage to the heart muscle.

Symptoms of a myocardial infarction can include chest pain or discomfort, shortness of breath, lightheadedness, and fatigue. These symptoms may be accompanied by anxiety, fear, and a sense of impending doom. In some cases, there may be no noticeable symptoms at all.

Diagnosis of myocardial infarction is typically made based on a combination of physical examination findings, medical history, and diagnostic tests such as an electrocardiogram (ECG), cardiac enzyme tests, and imaging studies like echocardiography or cardiac magnetic resonance imaging.

Treatment of myocardial infarction usually involves medications to relieve pain, reduce the amount of work the heart has to do, and prevent further damage to the heart muscle. These may include aspirin, beta blockers, ACE inhibitors or angiotensin receptor blockers, and statins. In some cases, a procedure such as angioplasty or coronary artery bypass surgery may be necessary to restore blood flow to the affected area.

Prevention of myocardial infarction involves managing risk factors such as high blood pressure, high cholesterol, smoking, diabetes, and obesity. This can include lifestyle changes such as a healthy diet, regular exercise, and stress reduction, as well as medications to control these conditions. Early detection and treatment of heart disease can help prevent myocardial infarction from occurring in the first place.

Angina pectoris is a medical condition that is characterized by recurring chest pain or discomfort due to reduced blood flow and oxygen supply to the heart muscle, specifically the myocardium. It is also known as stable angina or effort angina. The symptoms of angina pectoris typically occur during physical activity or emotional stress and are relieved by rest.

The term "angina" comes from the Latin word for "strangulation," which refers to the feeling of tightness or constriction in the chest that is associated with the condition. Angina pectoris can be caused by atherosclerosis, or the buildup of plaque in the coronary arteries, which supply blood to the heart muscle. This buildup can lead to the formation of atherosclerotic plaques that can narrow the coronary arteries and reduce blood flow to the heart muscle, causing chest pain.

There are several types of angina pectoris, including:

1. Stable angina: This is the most common type of angina and is characterized by predictable and reproducible symptoms that occur during specific situations or activities, such as exercise or emotional stress.
2. Unstable angina: This type of angina is characterized by unpredictable and changing symptoms that can occur at rest or with minimal exertion. It is often a sign of a more severe underlying condition, such as a heart attack.
3. Variant angina: This type of angina occurs during physical activity, but the symptoms are not relieved by rest.
4. Prinzmetal's angina: This is a rare type of angina that occurs at rest and is characterized by a feeling of tightness or constriction in the chest.

The diagnosis of angina pectoris is typically made based on a combination of physical examination, medical history, and diagnostic tests such as electrocardiogram (ECG), stress test, and imaging studies. Treatment for angina pectoris usually involves lifestyle modifications, such as regular exercise, a healthy diet, and stress management, as well as medications to relieve symptoms and reduce the risk of complications. In some cases, surgery or other procedures may be necessary to treat the underlying condition causing the angina.

1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.

2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.

3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.

4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.

5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.

6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.

7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.

8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.

9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.

10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.

There are many different types of cardiac arrhythmias, including:

1. Tachycardias: These are fast heart rhythms that can be too fast for the body's needs. Examples include atrial fibrillation and ventricular tachycardia.
2. Bradycardias: These are slow heart rhythms that can cause symptoms like fatigue, dizziness, and fainting. Examples include sinus bradycardia and heart block.
3. Premature beats: These are extra beats that occur before the next regular beat should come in. They can be benign but can also indicate an underlying arrhythmia.
4. Supraventricular arrhythmias: These are arrhythmias that originate above the ventricles, such as atrial fibrillation and paroxysmal atrial tachycardia.
5. Ventricular arrhythmias: These are arrhythmias that originate in the ventricles, such as ventricular tachycardia and ventricular fibrillation.

Cardiac arrhythmias can be diagnosed through a variety of tests including electrocardiograms (ECGs), stress tests, and holter monitors. Treatment options for cardiac arrhythmias vary depending on the type and severity of the condition and may include medications, cardioversion, catheter ablation, or implantable devices like pacemakers or defibrillators.

Example sentence: "The patient experienced a transient ischemic attack, which was caused by a temporary blockage in one of the blood vessels in their brain."

Synonyms: TIA, mini-stroke.

During myocardial stunning, the heart muscle cells experience a temporary reduction in contractility and an increase in the amount of lactic acid produced. This can lead to symptoms such as chest pain, shortness of breath, and fatigue. In severe cases, myocardial stunning can progress to myocardial infarction (heart attack) or cardiac arrest.

Myocardial stunning is often seen in athletes who engage in intense exercise, such as marathon runners or professional football players. It can also occur in people with pre-existing heart conditions, such as coronary artery disease or hypertension.

Treatment of myocardial stunning typically involves addressing the underlying cause, such as reducing stress on the heart or improving blood flow to the myocardium. In severe cases, medications such as nitrates or beta blockers may be used to reduce the workload on the heart and improve contractility. In some cases, hospitalization may be necessary to monitor the condition and provide appropriate treatment.

Prevention of myocardial stunning involves taking steps to reduce the risk factors for heart disease, such as maintaining a healthy diet, exercising regularly, and managing stress. It is also important to seek medical attention if symptoms of myocardial stunning are present, as prompt treatment can help prevent more severe complications.

The buildup of plaque in the coronary arteries is often caused by high levels of low-density lipoprotein (LDL) cholesterol, smoking, high blood pressure, diabetes, and a family history of heart disease. The plaque can also rupture, causing a blood clot to form, which can completely block the flow of blood to the heart muscle, leading to a heart attack.

CAD is the most common type of heart disease and is often asymptomatic until a serious event occurs. Risk factors for CAD include:

* Age (men over 45 and women over 55)
* Gender (men are at greater risk than women, but women are more likely to die from CAD)
* Family history of heart disease
* High blood pressure
* High cholesterol
* Diabetes
* Smoking
* Obesity
* Lack of exercise

Diagnosis of CAD typically involves a physical exam, medical history, and results of diagnostic tests such as:

* Electrocardiogram (ECG or EKG)
* Stress test
* Echocardiogram
* Coronary angiography

Treatment for CAD may include lifestyle changes such as a healthy diet, regular exercise, stress management, and quitting smoking. Medications such as beta blockers, ACE inhibitors, and statins may also be prescribed to manage symptoms and slow the progression of the disease. In severe cases, surgical intervention such as coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) may be necessary.

Prevention of CAD includes managing risk factors such as high blood pressure, high cholesterol, and diabetes, quitting smoking, maintaining a healthy weight, and getting regular exercise. Early detection and treatment of CAD can help to reduce the risk of complications and improve quality of life for those affected by the disease.

Some common examples of intraoperative complications include:

1. Bleeding: Excessive bleeding during surgery can lead to hypovolemia (low blood volume), anemia (low red blood cell count), and even death.
2. Infection: Surgical wounds can become infected, leading to sepsis or bacteremia (bacterial infection of the bloodstream).
3. Nerve damage: Surgery can sometimes result in nerve damage, leading to numbness, weakness, or paralysis.
4. Organ injury: Injury to organs such as the liver, lung, or bowel can occur during surgery, leading to complications such as bleeding, infection, or organ failure.
5. Anesthesia-related complications: Problems with anesthesia can include respiratory or cardiac depression, allergic reactions, or awareness during anesthesia (a rare but potentially devastating complication).
6. Hypotension: Low blood pressure during surgery can lead to inadequate perfusion of vital organs and tissues, resulting in organ damage or death.
7. Thromboembolism: Blood clots can form during surgery and travel to other parts of the body, causing complications such as stroke, pulmonary embolism, or deep vein thrombosis.
8. Postoperative respiratory failure: Respiratory complications can occur after surgery, leading to respiratory failure, pneumonia, or acute respiratory distress syndrome (ARDS).
9. Wound dehiscence: The incision site can separate or come open after surgery, leading to infection, fluid accumulation, or hernia.
10. Seroma: A collection of serous fluid that can develop at the surgical site, which can become infected and cause complications.
11. Nerve damage: Injury to nerves during surgery can result in numbness, weakness, or paralysis, sometimes permanently.
12. Urinary retention or incontinence: Surgery can damage the bladder or urinary sphincter, leading to urinary retention or incontinence.
13. Hematoma: A collection of blood that can develop at the surgical site, which can become infected and cause complications.
14. Pneumonia: Inflammation of the lungs after surgery can be caused by bacteria, viruses, or fungi and can lead to serious complications.
15. Sepsis: A systemic inflammatory response to infection that can occur after surgery, leading to organ dysfunction and death if not treated promptly.

It is important to note that these are potential complications, and not all patients will experience them. Additionally, many of these complications are rare, and the vast majority of surgeries are successful with minimal or no complications. However, it is important for patients to be aware of the potential risks before undergoing surgery so they can make an informed decision about their care.

There are several possible causes of chest pain, including:

1. Coronary artery disease: The most common cause of chest pain is coronary artery disease, which occurs when the coronary arteries that supply blood to the heart become narrowed or blocked. This can lead to a heart attack if the blood flow to the heart muscle is severely reduced.
2. Heart attack: A heart attack occurs when the heart muscle becomes damaged or dies due to a lack of oxygen and nutrients. This can cause severe chest pain, as well as other symptoms such as shortness of breath, lightheadedness, and fatigue.
3. Acute coronary syndrome: This is a group of conditions that occur when the blood flow to the heart muscle is suddenly blocked or reduced, leading to chest pain or discomfort. In addition to heart attack, acute coronary syndrome can include unstable angina and non-ST-segment elevation myocardial infarction (NSTEMI).
4. Pulmonary embolism: A pulmonary embolism occurs when a blood clot forms in the lungs and blocks the flow of blood to the heart, causing chest pain and shortness of breath.
5. Pneumonia: An infection of the lungs can cause chest pain, fever, and difficulty breathing.
6. Costochondritis: This is an inflammation of the cartilage that connects the ribs to the breastbone (sternum), which can cause chest pain and tenderness.
7. Tietze's syndrome: This is a condition that occurs when the cartilage and muscles in the chest are injured, leading to chest pain and swelling.
8. Heart failure: When the heart is unable to pump enough blood to meet the body's needs, it can cause chest pain, shortness of breath, and fatigue.
9. Pericarditis: An inflammation of the membrane that surrounds the heart (pericardium) can cause chest pain, fever, and difficulty breathing.
10. Precordial catch syndrome: This is a condition that occurs when the muscles and tendons between the ribs become inflamed, causing chest pain and tenderness.

These are just a few of the many possible causes of chest pain. If you are experiencing chest pain, it is important to seek medical attention right away to determine the cause and receive proper treatment.

Symptoms of Spinal Cord Ischemia may include weakness, paralysis, loss of sensation, and loss of reflexes in the affected area. Diagnosis is typically made through a combination of physical examination, imaging studies such as MRI or CT scans, and laboratory tests.

Treatment for Spinal Cord Ischemia depends on the underlying cause and may include medications to dissolve blood clots, surgery to repair arterial damage, or supportive care to manage symptoms and prevent further damage. In severe cases, Spinal Cord Ischemia can lead to permanent neurological damage or death.

Spinal Cord Ischemia is a serious medical condition that requires prompt diagnosis and treatment to prevent long-term neurological damage or death.

In Vfib, the electrical activity of the heart becomes disorganized, leading to a fibrillatory pattern of contraction. This means that the ventricles are contracting in a rapid, unsynchronized manner, rather than the coordinated, synchronized contractions that occur in normal heart function.

Vfib can be caused by a variety of factors, including coronary artery disease, heart attack, cardiomyopathy, and electrolyte imbalances. It can also be triggered by certain medications, such as digoxin, or by electrical shocks to the heart.

Symptoms of Vfib include palpitations, shortness of breath, chest pain, and loss of consciousness. If not treated promptly, Vfib can lead to cardiac arrest and death.

Treatment of Vfib typically involves electrical cardioversion, which involves delivering an electric shock to the heart to restore a normal heart rhythm. In some cases, medications may also be used to help regulate the heart rhythm. In more severe cases, surgery or other interventions may be necessary to address any underlying causes of Vfib.

Overall, ventricular fibrillation is a serious medical condition that requires prompt treatment to prevent complications and ensure effective cardiac function.

Examples of acute diseases include:

1. Common cold and flu
2. Pneumonia and bronchitis
3. Appendicitis and other abdominal emergencies
4. Heart attacks and strokes
5. Asthma attacks and allergic reactions
6. Skin infections and cellulitis
7. Urinary tract infections
8. Sinusitis and meningitis
9. Gastroenteritis and food poisoning
10. Sprains, strains, and fractures.

Acute diseases can be treated effectively with antibiotics, medications, or other therapies. However, if left untreated, they can lead to chronic conditions or complications that may require long-term care. Therefore, it is important to seek medical attention promptly if symptoms persist or worsen over time.

The severity of coronary stenosis can range from mild to severe, with blockages ranging from 15% to over 90%. In mild cases, lifestyle changes and medication may be enough to manage symptoms. However, more severe cases typically require interventional procedures such as angioplasty or bypass surgery to improve blood flow to the heart.

Word origin: Greek "anginos" meaning "pain in the neck".

Necrosis is a type of cell death that occurs when cells are exposed to excessive stress, injury, or inflammation, leading to damage to the cell membrane and the release of cellular contents into the surrounding tissue. This can lead to the formation of gangrene, which is the death of body tissue due to lack of blood supply.

There are several types of necrosis, including:

1. Coagulative necrosis: This type of necrosis occurs when there is a lack of blood supply to the tissues, leading to the formation of a firm, white plaque on the surface of the affected area.
2. Liquefactive necrosis: This type of necrosis occurs when there is an infection or inflammation that causes the death of cells and the formation of pus.
3. Caseous necrosis: This type of necrosis occurs when there is a chronic infection, such as tuberculosis, and the affected tissue becomes soft and cheese-like.
4. Fat necrosis: This type of necrosis occurs when there is trauma to fatty tissue, leading to the formation of firm, yellowish nodules.
5. Necrotizing fasciitis: This is a severe and life-threatening form of necrosis that affects the skin and underlying tissues, often as a result of bacterial infection.

The diagnosis of necrosis is typically made through a combination of physical examination, imaging studies such as X-rays or CT scans, and laboratory tests such as biopsy. Treatment depends on the underlying cause of the necrosis and may include antibiotics, surgical debridement, or amputation in severe cases.

The causes of angina pectoris, variant are not well understood, but it is believed to be related to a decrease in blood flow to the heart muscle, particularly during times of rest or low exertion. This can lead to a lack of oxygen and nutrients to the heart muscle, which can cause pain.

The diagnosis of angina pectoris, variant is based on a combination of clinical symptoms, physical examination findings, and results of diagnostic tests such as electrocardiography (ECG), stress test, and echocardiography. Treatment for this condition typically involves medications such as nitrates, calcium channel blockers, and beta-blockers to relieve pain and improve blood flow to the heart muscle. In some cases, surgery may be necessary to improve blood flow or to treat underlying conditions that are contributing to the angina.

Prevention of angina pectoris, variant includes lifestyle modifications such as regular exercise, stress reduction techniques, and avoiding smoking and alcohol consumption. It is important for individuals with this condition to work closely with their healthcare provider to manage their symptoms and prevent complications.

1. Accessory coronary arteries: These are extra coronary arteries that arise from the aortic sinus or the pulmonary trunk and supply blood to the heart muscle.
2. Coronary artery fistula: This is an abnormal connection between two coronary arteries or between a coronary artery and another cardiac structure, such as the left atrium or ventricle.
3. Coronary artery malformations: These are abnormalities in the origin, course, or termination of the coronary arteries.
4. Coronary atherosclerosis: This is the buildup of plaque in the coronary arteries, which can lead to reduced blood flow to the heart muscle and increase the risk of heart attack.
5. Coronary vasospasm: This is a temporary narrowing of the coronary arteries, often triggered by stress or certain medications.

Coronary vessel anomalies can be diagnosed using various imaging tests such as angiography, CT scans, and MRI. Treatment options for these anomalies depend on the severity of the condition and may include medications, lifestyle changes, or surgical interventions. It is important to identify and address coronary vessel anomalies to prevent or manage cardiac conditions such as heart attack, heart failure, and arrhythmias.

There are several potential causes of LVD, including:

1. Coronary artery disease: The buildup of plaque in the coronary arteries can lead to a heart attack, which can damage the left ventricle and impair its ability to function properly.
2. Heart failure: When the heart is unable to pump enough blood to meet the body's needs, it can lead to LVD.
3. Cardiomyopathy: This is a condition where the heart muscle becomes weakened or enlarged, leading to impaired function of the left ventricle.
4. Heart valve disease: Problems with the heart valves can disrupt the normal flow of blood and cause LVD.
5. Hypertension: High blood pressure can cause damage to the heart muscle and lead to LVD.
6. Genetic factors: Some people may be born with genetic mutations that predispose them to developing LVD.
7. Viral infections: Certain viral infections, such as myocarditis, can inflame and damage the heart muscle, leading to LVD.
8. Alcohol or drug abuse: Substance abuse can damage the heart muscle and lead to LVD.
9. Nutritional deficiencies: A diet lacking essential nutrients can lead to damage to the heart muscle and increase the risk of LVD.

Diagnosis of LVD typically involves a physical exam, medical history, and results of diagnostic tests such as electrocardiograms (ECGs), echocardiograms, and stress tests. Treatment options for LVD depend on the underlying cause, but may include medications to improve cardiac function, lifestyle changes, and in severe cases, surgery or other procedures.

Preventing LVD involves taking steps to maintain a healthy heart and reducing risk factors such as high blood pressure, smoking, and obesity. This can be achieved through a balanced diet, regular exercise, stress management, and avoiding substance abuse. Early detection and treatment of underlying conditions that increase the risk of LVD can also help prevent the condition from developing.

Infarction Middle Cerebral Artery (MCA) is a type of ischemic stroke that occurs when there is an obstruction in the middle cerebral artery. This artery supplies blood to the temporal lobe of the brain, which controls many important functions such as memory, language, and spatial reasoning. When this artery becomes blocked or ruptured, it can cause a lack of blood supply to the affected areas resulting in tissue death (infarction).

The symptoms of an MCA infarction can vary depending on the location and severity of the blockage. Some common symptoms include weakness or paralysis on one side of the body, difficulty with speech and language, memory loss, confusion, vision problems, and difficulty with coordination and balance. Patients may also experience sudden severe headache, nausea, vomiting, and fever.

The diagnosis of MCA infarction is based on a combination of clinical examination, imaging studies such as CT or MRI scans, and laboratory tests. Imaging studies can help to identify the location and severity of the blockage, while laboratory tests may be used to rule out other conditions that may cause similar symptoms.

Treatment for MCA infarction depends on the underlying cause of the blockage or rupture. In some cases, medications such as thrombolytics may be given to dissolve blood clots and restore blood flow to the affected areas. Surgery may also be required to remove any blockages or repair damaged blood vessels. Other interventions such as endovascular procedures or brain bypass surgery may also be used to restore blood flow.

In summary, middle cerebral artery infarction is a type of stroke that occurs when the blood supply to the brain is blocked or interrupted, leading to damage to the brain tissue. It can cause a range of symptoms including weakness or paralysis on one side of the body, difficulty with speech and language, memory loss, confusion, vision problems, and difficulty with coordination and balance. The diagnosis is based on a combination of clinical examination, imaging studies, and laboratory tests. Treatment options include medications, surgery, endovascular procedures, or brain bypass surgery.

Word Origin: From coronary (pertaining to the crown) + vasospasm (a spasmodic constriction of a blood vessel).

The symptoms of microvascular angina are similar to those of stable angina, including chest pain or discomfort, shortness of breath, and fatigue. However, microvascular angina episodes can be more frequent and unpredictable than stable angina, and may occur at rest or with minimal exertion.

The diagnosis of microvascular angina is based on a combination of clinical symptoms, physical examination findings, and diagnostic tests such as electrocardiography (ECG), echocardiography, and coronary angiography. Treatment for microvascular angina typically involves medications to relax the blood vessels and improve blood flow to the heart, as well as lifestyle changes such as regular exercise and a healthy diet. In severe cases, surgical intervention may be necessary.

Microvascular angina is considered a syndrome rather than a disease, and it is believed to be caused by a combination of genetic and environmental factors, including smoking, high blood pressure, and high cholesterol levels. It is more common in people who are middle-aged or older, and affects men and women equally.

Overall, microvascular angina is a serious condition that can have a significant impact on quality of life, and it is important for individuals who experience symptoms to seek medical attention to receive an accurate diagnosis and appropriate treatment. With proper management, many people with microvascular angina are able to lead active and fulfilling lives.

Types of Arterial Occlusive Diseases:

1. Atherosclerosis: Atherosclerosis is a condition where plaque builds up inside the arteries, leading to narrowing or blockages that can restrict blood flow to certain areas of the body.
2. Peripheral Artery Disease (PAD): PAD is a condition where the blood vessels in the legs and arms become narrowed or blocked, leading to pain or cramping in the affected limbs.
3. Coronary Artery Disease (CAD): CAD is a condition where the coronary arteries, which supply blood to the heart, become narrowed or blocked, leading to chest pain or a heart attack.
4. Carotid Artery Disease: Carotid artery disease is a condition where the carotid arteries, which supply blood to the brain, become narrowed or blocked, leading to stroke or mini-stroke.
5. Renal Artery Stenosis: Renal artery stenosis is a condition where the blood vessels that supply the kidneys become narrowed or blocked, leading to high blood pressure and decreased kidney function.

Symptoms of Arterial Occlusive Diseases:

1. Pain or cramping in the affected limbs
2. Weakness or fatigue
3. Difficulty walking or standing
4. Chest pain or discomfort
5. Shortness of breath
6. Dizziness or lightheadedness
7. Stroke or mini-stroke

Treatment for Arterial Occlusive Diseases:

1. Medications: Medications such as blood thinners, cholesterol-lowering drugs, and blood pressure medications may be prescribed to treat arterial occlusive diseases.
2. Lifestyle Changes: Lifestyle changes such as quitting smoking, exercising regularly, and eating a healthy diet can help manage symptoms and slow the progression of the disease.
3. Endovascular Procedures: Endovascular procedures such as angioplasty and stenting may be performed to open up narrowed or blocked blood vessels.
4. Surgery: In some cases, surgery may be necessary to treat arterial occlusive diseases, such as bypass surgery or carotid endarterectomy.

Prevention of Arterial Occlusive Diseases:

1. Maintain a healthy diet and lifestyle
2. Quit smoking and avoid exposure to secondhand smoke
3. Exercise regularly
4. Manage high blood pressure, high cholesterol, and diabetes
5. Avoid excessive alcohol consumption
6. Get regular check-ups with your healthcare provider

Early detection and treatment of arterial occlusive diseases can help manage symptoms, slow the progression of the disease, and prevent complications such as heart attack or stroke.

The term "asymptomatic" means "not showing symptoms."

In medical terminology, the word asymptomatic is used to describe a person who has a disease or condition but does not show any symptoms. Symptoms are changes in the body or mind that indicate the presence of a disease or condition. For example, fever, pain, and fatigue are all symptoms of an infection.

Asymptomatic diseases can be difficult to diagnose because they do not cause any noticeable symptoms. In many cases, these diseases are only discovered through routine medical testing or exams. For example, a person may have high blood pressure without knowing it, as there are usually no noticeable symptoms until the condition is advanced.

The importance of screening tests and early diagnosis

Screening tests are medical tests that are performed on people who do not have any symptoms of a disease or condition. These tests are designed to detect diseases or conditions before they cause any noticeable symptoms. Examples of screening tests include blood pressure checks, cholesterol tests, mammograms, and colonoscopies.

Early diagnosis is critical for successfully treating many asymptomatic diseases. When a disease or condition is detected early, it can be treated more effectively before it causes any significant damage. In some cases, early diagnosis may even prevent the development of complications.

The importance of screening tests and early diagnosis cannot be overstated. By detecting diseases or conditions before they cause symptoms, individuals can receive treatment before any long-term damage occurs. This can help to improve their quality of life, increase their lifespan, and reduce the risk of complications.

The importance of screening tests and early diagnosis is particularly important for certain populations, such as older adults or those with a family history of certain diseases or conditions. These individuals may be at a higher risk for developing certain asymptomatic diseases, and screening tests can help to detect these conditions before they cause any noticeable symptoms.

The benefits of early diagnosis include:

1. Improved treatment outcomes: When a disease or condition is detected early, it can be treated more effectively before it causes any significant damage. This can improve the chances of successful treatment and reduce the risk of complications.
2. Prevention of long-term damage: By detecting diseases or conditions before they cause any noticeable symptoms, individuals can receive treatment before any long-term damage occurs. This can help to preserve their quality of life and increase their lifespan.
3. Reduced healthcare costs: Early diagnosis can reduce healthcare costs by preventing the need for more expensive treatments or hospitalizations that may be required if a condition is allowed to progress untreated.
4. Increased awareness: Screening tests and early diagnosis can increase awareness of certain diseases or conditions, which can lead to increased education and advocacy efforts aimed at prevention and treatment.
5. Improved patient outcomes: Early diagnosis can lead to improved patient outcomes by allowing for earlier intervention and treatment, which can improve the chances of successful treatment and reduce the risk of complications.
6. Reduced suffering: By detecting diseases or conditions before they cause any noticeable symptoms, individuals can receive treatment before they experience any unnecessary suffering.
7. Increased survival rates: Early diagnosis can lead to increased survival rates for certain diseases or conditions, particularly those that are more treatable when detected early.
8. Better management of chronic conditions: Screening tests and early diagnosis can help individuals with chronic conditions to manage their condition more effectively, which can improve their quality of life and increase their lifespan.
9. Improved patient satisfaction: Early diagnosis can lead to improved patient satisfaction by providing individuals with a sense of control over their health and well-being.
10. Reduced anxiety: By detecting diseases or conditions before they cause any noticeable symptoms, individuals may experience reduced anxiety about their health and well-being.

Overall, early diagnosis has the potential to significantly improve patient outcomes and quality of life for individuals with a wide range of medical conditions. It is important for healthcare providers to prioritize early diagnosis and screening tests in order to provide the best possible care for their patients.

Cerebral infarction can result in a range of symptoms, including sudden weakness or numbness in the face, arm, or leg on one side of the body, difficulty speaking or understanding speech, sudden vision loss, dizziness, and confusion. Depending on the location and severity of the infarction, it can lead to long-term disability or even death.

There are several types of cerebral infarction, including:

1. Ischemic stroke: This is the most common type of cerebral infarction, accounting for around 87% of all cases. It occurs when a blood clot blocks the flow of blood to the brain, leading to cell death and tissue damage.
2. Hemorrhagic stroke: This type of cerebral infarction occurs when a blood vessel in the brain ruptures, leading to bleeding and cell death.
3. Lacunar infarction: This type of cerebral infarction affects the deep structures of the brain, particularly the basal ganglia, and is often caused by small blockages or stenosis (narrowing) in the blood vessels.
4. Territorial infarction: This type of cerebral infarction occurs when there is a complete blockage of a blood vessel that supplies a specific area of the brain, leading to cell death and tissue damage in that area.

Diagnosis of cerebral infarction typically involves a combination of physical examination, medical history, and imaging tests such as CT or MRI scans. Treatment options vary depending on the cause and location of the infarction, but may include medication to dissolve blood clots, surgery to remove blockages, or supportive care to manage symptoms and prevent complications.

There are several types of acidosis, including:

1. Respiratory acidosis: This occurs when the lung's ability to remove carbon dioxide from the blood is impaired, leading to an increase in blood acidity.
2. Metabolic acidosis: This type of acidosis occurs when there is an excessive production of acid in the body due to factors such as diabetes, starvation, or kidney disease.
3. Mixed acidosis: This type of acidosis is a combination of respiratory and metabolic acidosis.
4. Severe acute respiratory acidosis (SARA): This is a life-threatening condition that occurs suddenly, usually due to a severe lung injury or aspiration of a corrosive substance.

The symptoms of acidosis can vary depending on the type and severity of the condition. Common symptoms include:

1. Fatigue
2. Weakness
3. Confusion
4. Headaches
5. Nausea and vomiting
6. Abdominal pain
7. Difficulty breathing
8. Rapid heart rate
9. Muscle twitching

If left untreated, acidosis can lead to complications such as:

1. Kidney damage
2. Seizures
3. Coma
4. Heart arrhythmias
5. Respiratory failure

Treatment of acidosis depends on the underlying cause and the severity of the condition. Some common treatments include:

1. Oxygen therapy
2. Medications to help regulate breathing and heart rate
3. Fluid and electrolyte replacement
4. Dietary changes
5. Surgery, in severe cases.

In conclusion, acidosis is a serious medical condition that can have severe consequences if left untreated. It is important to seek medical attention immediately if you suspect that you or someone else may have acidosis. With prompt and appropriate treatment, it is possible to effectively manage the condition and prevent complications.

There are different types of anoxia, including:

1. Cerebral anoxia: This occurs when the brain does not receive enough oxygen, leading to cognitive impairment, confusion, and loss of consciousness.
2. Pulmonary anoxia: This occurs when the lungs do not receive enough oxygen, leading to shortness of breath, coughing, and chest pain.
3. Cardiac anoxia: This occurs when the heart does not receive enough oxygen, leading to cardiac arrest and potentially death.
4. Global anoxia: This is a complete lack of oxygen to the entire body, leading to widespread tissue damage and death.

Treatment for anoxia depends on the underlying cause and the severity of the condition. In some cases, hospitalization may be necessary to provide oxygen therapy, pain management, and other supportive care. In severe cases, anoxia can lead to long-term disability or death.

Prevention of anoxia is important, and this includes managing underlying medical conditions such as heart disease, diabetes, and respiratory problems. It also involves avoiding activities that can lead to oxygen deprivation, such as scuba diving or high-altitude climbing, without proper training and equipment.

In summary, anoxia is a serious medical condition that occurs when there is a lack of oxygen in the body or specific tissues or organs. It can cause cell death and tissue damage, leading to serious health complications and even death if left untreated. Early diagnosis and treatment are crucial to prevent long-term disability or death.

The burden of chronic diseases is significant, with over 70% of deaths worldwide attributed to them, according to the World Health Organization (WHO). In addition to the physical and emotional toll they take on individuals and their families, chronic diseases also pose a significant economic burden, accounting for a large proportion of healthcare expenditure.

In this article, we will explore the definition and impact of chronic diseases, as well as strategies for managing and living with them. We will also discuss the importance of early detection and prevention, as well as the role of healthcare providers in addressing the needs of individuals with chronic diseases.

What is a Chronic Disease?

A chronic disease is a condition that lasts for an extended period of time, often affecting daily life and activities. Unlike acute diseases, which have a specific beginning and end, chronic diseases are long-term and persistent. Examples of chronic diseases include:

1. Diabetes
2. Heart disease
3. Arthritis
4. Asthma
5. Cancer
6. Chronic obstructive pulmonary disease (COPD)
7. Chronic kidney disease (CKD)
8. Hypertension
9. Osteoporosis
10. Stroke

Impact of Chronic Diseases

The burden of chronic diseases is significant, with over 70% of deaths worldwide attributed to them, according to the WHO. In addition to the physical and emotional toll they take on individuals and their families, chronic diseases also pose a significant economic burden, accounting for a large proportion of healthcare expenditure.

Chronic diseases can also have a significant impact on an individual's quality of life, limiting their ability to participate in activities they enjoy and affecting their relationships with family and friends. Moreover, the financial burden of chronic diseases can lead to poverty and reduce economic productivity, thus having a broader societal impact.

Addressing Chronic Diseases

Given the significant burden of chronic diseases, it is essential that we address them effectively. This requires a multi-faceted approach that includes:

1. Lifestyle modifications: Encouraging healthy behaviors such as regular physical activity, a balanced diet, and smoking cessation can help prevent and manage chronic diseases.
2. Early detection and diagnosis: Identifying risk factors and detecting diseases early can help prevent or delay their progression.
3. Medication management: Effective medication management is crucial for controlling symptoms and slowing disease progression.
4. Multi-disciplinary care: Collaboration between healthcare providers, patients, and families is essential for managing chronic diseases.
5. Health promotion and disease prevention: Educating individuals about the risks of chronic diseases and promoting healthy behaviors can help prevent their onset.
6. Addressing social determinants of health: Social determinants such as poverty, education, and employment can have a significant impact on health outcomes. Addressing these factors is essential for reducing health disparities and improving overall health.
7. Investing in healthcare infrastructure: Investing in healthcare infrastructure, technology, and research is necessary to improve disease detection, diagnosis, and treatment.
8. Encouraging policy change: Policy changes can help create supportive environments for healthy behaviors and reduce the burden of chronic diseases.
9. Increasing public awareness: Raising public awareness about the risks and consequences of chronic diseases can help individuals make informed decisions about their health.
10. Providing support for caregivers: Chronic diseases can have a significant impact on family members and caregivers, so providing them with support is essential for improving overall health outcomes.

Conclusion

Chronic diseases are a major public health burden that affect millions of people worldwide. Addressing these diseases requires a multi-faceted approach that includes lifestyle changes, addressing social determinants of health, investing in healthcare infrastructure, encouraging policy change, increasing public awareness, and providing support for caregivers. By taking a comprehensive approach to chronic disease prevention and management, we can improve the health and well-being of individuals and communities worldwide.

There are several types of coronary occlusion, including:

* Complete coronary occlusion: When all blood flow to the heart is blocked.
* Incomplete coronary occlusion: When only part of the coronary artery is blocked.
* Proximal coronary occlusion: When the blockage occurs closer to the origins of the coronary arteries.
* Distal coronary occlusion: When the blockage occurs further down the coronary arteries, closer to the heart muscle.

The symptoms of coronary occlusion can vary depending on the location and severity of the blockage, but may include:

* Chest pain or discomfort (angina)
* Shortness of breath
* Fatigue
* Dizziness or lightheadedness
* Palpitations

Coronary occlusion can be diagnosed through various tests such as electrocardiogram (ECG), stress test, echocardiogram, and coronary angiography. Treatment options for coronary occlusion include medications to reduce blood pressure and improve blood flow, angioplasty or stenting to open or clear the blockage, and in some cases, coronary artery bypass surgery.

Preventive measures to reduce the risk of coronary occlusion include:

* Maintaining a healthy diet and lifestyle
* Not smoking
* Managing high blood pressure, high cholesterol, and diabetes
* Exercising regularly
* Maintaining a healthy weight

Early diagnosis and treatment of coronary occlusion can help improve outcomes and reduce the risk of complications such as heart attack or death.

1. Infection: Bacterial or viral infections can develop after surgery, potentially leading to sepsis or organ failure.
2. Adhesions: Scar tissue can form during the healing process, which can cause bowel obstruction, chronic pain, or other complications.
3. Wound complications: Incisional hernias, wound dehiscence (separation of the wound edges), and wound infections can occur.
4. Respiratory problems: Pneumonia, respiratory failure, and atelectasis (collapsed lung) can develop after surgery, particularly in older adults or those with pre-existing respiratory conditions.
5. Cardiovascular complications: Myocardial infarction (heart attack), cardiac arrhythmias, and cardiac failure can occur after surgery, especially in high-risk patients.
6. Renal (kidney) problems: Acute kidney injury or chronic kidney disease can develop postoperatively, particularly in patients with pre-existing renal impairment.
7. Neurological complications: Stroke, seizures, and neuropraxia (nerve damage) can occur after surgery, especially in patients with pre-existing neurological conditions.
8. Pulmonary embolism: Blood clots can form in the legs or lungs after surgery, potentially causing pulmonary embolism.
9. Anesthesia-related complications: Respiratory and cardiac complications can occur during anesthesia, including respiratory and cardiac arrest.
10. delayed healing: Wound healing may be delayed or impaired after surgery, particularly in patients with pre-existing medical conditions.

It is important for patients to be aware of these potential complications and to discuss any concerns with their surgeon and healthcare team before undergoing surgery.

Mesenteric vascular occlusion can be caused by various factors, such as atherosclerosis (hardening of the arteries), blood clots, or inflammation. This condition can lead to a reduction in blood flow to the intestines, which can cause symptoms such as abdominal pain, diarrhea, and vomiting. In severe cases, it can also lead to tissue death and potentially life-threatening complications.

There are several types of mesenteric vascular occlusion, including:

1. Acute mesenteric ischemia (AMI): This is a sudden and severe blockage of the blood vessels that supply the intestines, which can cause tissue death and potentially life-threatening complications.
2. Chronic mesenteric ischemia (CMI): This is a gradual and less severe blockage of the blood vessels that supply the intestines, which can cause symptoms such as abdominal pain and diarrhea.
3. Mesenteric venous thrombosis: This is the formation of a blood clot in the veins that drain blood from the intestines.

Diagnosis of mesenteric vascular occlusion typically involves imaging tests such as CT or MRI scans, and blood tests to check for signs of inflammation or tissue damage. Treatment options vary depending on the severity and cause of the condition, and may include medications to dissolve blood clots, surgery to repair or bypass blocked blood vessels, or in severe cases, removal of the affected intestine.

Myocardial bridging is a relatively rare condition that is often asymptomatic but may be detected incidentally during diagnostic tests such as coronary angiography or echocardiography. In some cases, myocardial bridging may cause symptoms such as chest pain or shortness of breath, particularly during physical activity.

The exact prevalence of myocardial bridging is not well established, but it is estimated to affect approximately 1-2% of the general population. Myocardial bridging can occur in any coronary artery, but it is more common in the left anterior descending (LAD) coronary artery.

Myocardial bridging can be caused by a variety of factors, including:

1. Congenital anomalies: Some individuals may be born with a myocardial bridge due to abnormal development of the heart during fetal life.
2. Heart disease: Myocardial bridging can occur as a result of coronary artery disease or other conditions that damage the heart muscle.
3. Inflammatory conditions: Certain inflammatory conditions, such as endocarditis or myopericarditis, can cause myocardial bridging.
4. Infections: Viral or bacterial infections can cause inflammation and scarring in the heart muscle, leading to myocardial bridging.
5. Trauma: Physical trauma to the chest or heart can cause myocardial bridging.

Myocardial bridging can be diagnosed using a variety of imaging tests, including:

1. Coronary angiography: This test involves injecting dye into the coronary arteries to visualize the vessels and detect any blockages or abnormalities.
2. Echocardiography: This test uses ultrasound waves to create images of the heart and can help identify myocardial bridging.
3. Cardiac MRI: This test provides detailed images of the heart and can help diagnose myocardial bridging and other conditions.
4. CT scan: A computerized tomography (CT) scan can be used to visualize the heart and detect any abnormalities, including myocardial bridging.

Treatment for myocardial bridging depends on the underlying cause and severity of the condition. Some common treatment options include:

1. Medications: Medications such as beta blockers, calcium channel blockers, or anti-inflammatory drugs may be prescribed to manage symptoms and improve cardiac function.
2. Lifestyle changes: Making healthy lifestyle changes, such as quitting smoking, exercising regularly, and eating a balanced diet, can help improve cardiac function and reduce symptoms.
3. Surgery: In some cases, surgical intervention may be necessary to treat myocardial bridging. This may involve removing the bridge or repairing any damage to the heart muscle.
4. Cardiac catheterization: This procedure involves inserting a thin tube (catheter) into the coronary arteries to diagnose and treat blockages or other conditions that may be contributing to myocardial bridging.
5. Percutaneous coronary intervention (PCI): This minimally invasive procedure can be used to open up narrowed or blocked coronary arteries, improving blood flow to the heart muscle and reducing symptoms of myocardial bridging.

In some cases, myocardial bridging may be a sign of a more serious underlying condition, such as coronary artery disease or cardiomyopathy. If left untreated, myocardial bridging can lead to complications such as heart failure, arrhythmias, and even death. Therefore, it is important to seek medical attention if symptoms persist or worsen over time.

There are several types of tachycardia, including:

1. Sinus tachycardia: This is the most common type and is caused by an increase in the rate of the normal sinus node. It is often seen in response to physical activity or stress.
2. Atrial fibrillation: This is a type of arrhythmia where the heart's upper chambers (atria) contract irregularly and rapidly, leading to a rapid heart rate.
3. Ventricular tachycardia: This is a type of arrhythmia where the heart's lower chambers (ventricles) contract rapidly, often with a rate above 100 bpm.
4. Premature ventricular contractions (PVCs): These are early or extra beats that originate in the ventricles, causing a rapid heart rate.

Tachycardia can cause a range of symptoms, including palpitations, shortness of breath, chest pain, and dizziness. In severe cases, it can lead to cardiac arrhythmias, heart failure, and even death.

Diagnosis of tachycardia typically involves a physical examination, electrocardiogram (ECG), and other tests such as stress tests or echocardiography. Treatment options vary depending on the underlying cause, but may include medications to regulate the heart rate, cardioversion to restore a normal heart rhythm, or in severe cases, implantation of a pacemaker or defibrillator.

The symptoms of MCNS typically appear in infancy or early childhood and may include:

* Skin rashes and lesions
* Mucosal lesions (e.g., in the mouth, nose, and eyes)
* Enlarged lymph nodes
* Respiratory problems
* Fevers
* Fatigue

The exact cause of MCNS is not known, but it is believed to be related to an abnormal immune response. The disorder is usually inherited in an autosomal recessive pattern, which means that a child must inherit two copies of the mutated gene (one from each parent) to develop the condition.

There is no cure for MCNS, but treatment may involve medications to manage symptoms and prevent complications. Corticosteroids, immunosuppressive drugs, and antibiotics may be used to reduce inflammation and prevent infection. In severe cases, surgery may be necessary to remove affected tissue or repair deformities.

Prognosis for MCNS varies depending on the severity of the disorder and the presence of any complications. Some individuals with MCNS may experience mild symptoms and have a good quality of life, while others may have more severe symptoms and require ongoing medical care. With appropriate treatment, many individuals with MCNS can lead active and fulfilling lives.

The word "edema" comes from the Greek word "oidema", meaning swelling.

There are several types of diabetic angiopathies, including:

1. Peripheral artery disease (PAD): This occurs when the blood vessels in the legs and arms become narrowed or blocked, leading to reduced blood flow and oxygen supply to the limbs.
2. Peripheral neuropathy: This is damage to the nerves in the hands and feet, which can cause pain, numbness, and weakness.
3. Retinopathy: This is damage to the blood vessels in the retina, which can lead to vision loss and blindness.
4. Nephropathy: This is damage to the kidneys, which can lead to kidney failure and the need for dialysis.
5. Cardiovascular disease: This includes heart attack, stroke, and other conditions that affect the heart and blood vessels.

The risk of developing diabetic angiopathies increases with the duration of diabetes and the level of blood sugar control. Other factors that can increase the risk include high blood pressure, high cholesterol, smoking, and a family history of diabetes-related complications.

Symptoms of diabetic angiopathies can vary depending on the specific type of complication and the location of the affected blood vessels or nerves. Common symptoms include:

* Pain or discomfort in the arms, legs, hands, or feet
* Numbness or tingling sensations in the hands and feet
* Weakness or fatigue in the limbs
* Difficulty healing wounds or cuts
* Vision changes or blindness
* Kidney problems or failure
* Heart attack or stroke

Diagnosis of diabetic angiopathies typically involves a combination of physical examination, medical history, and diagnostic tests such as ultrasound, MRI, or CT scans. Treatment options vary depending on the specific type of complication and may include:

* Medications to control blood sugar levels, high blood pressure, and high cholesterol
* Lifestyle changes such as a healthy diet and regular exercise
* Surgery to repair or bypass affected blood vessels or nerves
* Dialysis for kidney failure
* In some cases, amputation of the affected limb

Preventing diabetic angiopathies involves managing diabetes effectively through a combination of medication, lifestyle changes, and regular medical check-ups. Early detection and treatment can help prevent or delay the progression of complications.

There are many different types of heart diseases, including:

1. Coronary artery disease: The buildup of plaque in the coronary arteries, which supply blood to the heart muscle, leading to chest pain or a heart attack.
2. Heart failure: When the heart is unable to pump enough blood to meet the body's needs, leading to fatigue, shortness of breath, and swelling in the legs.
3. Arrhythmias: Abnormal heart rhythms, such as atrial fibrillation or ventricular tachycardia, which can cause palpitations, dizziness, and shortness of breath.
4. Heart valve disease: Problems with the heart valves, which can lead to blood leaking back into the chambers or not being pumped effectively.
5. Cardiomyopathy: Disease of the heart muscle, which can lead to weakened heart function and heart failure.
6. Heart murmurs: Abnormal sounds heard during a heartbeat, which can be caused by defects in the heart valves or abnormal blood flow.
7. Congenital heart disease: Heart defects present at birth, such as holes in the heart or abnormal blood vessels.
8. Myocardial infarction (heart attack): Damage to the heart muscle due to a lack of oxygen, often caused by a blockage in a coronary artery.
9. Cardiac tamponade: Fluid accumulation around the heart, which can cause compression of the heart and lead to cardiac arrest.
10. Endocarditis: Infection of the inner lining of the heart, which can cause fever, fatigue, and heart valve damage.

Heart diseases can be diagnosed through various tests such as electrocardiogram (ECG), echocardiogram, stress test, and blood tests. Treatment options depend on the specific condition and may include lifestyle changes, medication, surgery, or a combination of these.

The underlying cause of ACS is typically a blockage in one of the coronary arteries, which supply blood to the heart muscle. This blockage can be caused by atherosclerosis, a condition in which plaque builds up in the arteries and narrows them, or by a blood clot that forms in the artery and blocks the flow of blood.

The diagnosis of ACS is typically made based on a combination of symptoms, physical examination findings, and results of diagnostic tests such as electrocardiograms (ECGs) and blood tests. Treatment for ACS usually involves medications to dissolve blood clots and reduce the amount of work the heart has to do, as well as procedures such as angioplasty or coronary artery bypass surgery to restore blood flow to the heart.

Preventive measures for ACS include managing risk factors such as high blood pressure, high cholesterol, smoking, and diabetes, as well as increasing physical activity and eating a healthy diet. Early diagnosis and treatment of ACS can help reduce the risk of complications and improve outcomes for patients.

A condition characterized by swelling of the heart and surrounding tissues due to an accumulation of fluid. This can occur as a result of various conditions such as heart failure, coronary artery disease, or cardiomyopathy. The swelling can lead to symptoms such as shortness of breath, fatigue, and difficulty exercising. Treatment options include diuretics, ACE inhibitors, and other medications to manage the underlying condition causing the edema.

Example sentence: "The patient was diagnosed with cardiac edema and started on a regimen of diuretics and ACE inhibitors to help reduce the swelling and improve their symptoms."

Types of Coronary Aneurysms:
There are two main types of coronary artery aneurysms:

1. Fusiform aneurysm: This is the most common type of CAA and occurs when the artery bulges outward in a fusiform shape, similar to a balloon.
2. Saccular aneurysm: This type of CAA occurs when there is a small outpouching or sac in the artery wall.

Causes and Risk Factors:
The exact cause of coronary artery aneurysms is not fully understood, but several risk factors have been identified, including:

1. Atherosclerosis: The buildup of plaque in the coronary arteries can lead to an aneurysm.
2. High blood pressure: Hypertension can put additional strain on the coronary arteries, increasing the risk of an aneurysm.
3. Heart disease: People with heart disease, such as coronary artery disease or heart failure, are at higher risk for developing a CAA.
4. Genetics: Some people may be more susceptible to CAA due to genetic factors.
5. Infections: Certain infections, such as endocarditis, can cause aneurysms in the coronary arteries.

Symptoms and Diagnosis:
Coronary artery aneurysms may not produce any symptoms, or they may cause mild chest pain or discomfort. In some cases, a CAA may be detected incidentally during a diagnostic test for another condition. Diagnosis is typically made using imaging tests such as:

1. Echocardiography: This non-invasive test uses sound waves to create images of the heart and can help identify any abnormalities in the coronary arteries.
2. Cardiac catheterization: During this test, a thin tube is inserted into the coronary arteries through a blood vessel in the arm or leg to evaluate blood flow and pressure within the heart.
3. Computed tomography (CT) angiography: This test uses X-rays and computer technology to create detailed images of the coronary arteries.
4. Magnetic resonance angiography (MRA): This non-invasive test uses magnetic fields and radio waves to create detailed images of the coronary arteries.

Treatment and Management:
The treatment and management of CAA depend on several factors, including the size and location of the aneurysm, the patient's overall health, and the presence of any other medical conditions. Treatment options may include:

1. Monitoring: Small aneurysms that are not causing symptoms may not require immediate treatment and can be monitored with regular check-ups.
2. Medications: Medications such as beta blockers, ACE inhibitors, or calcium channel blockers may be prescribed to control blood pressure, reduce stress on the aneurysm, and prevent complications.
3. Endovascular repair: In this minimally invasive procedure, a small tube is inserted through a blood vessel in the leg and guided to the site of the aneurysm. Once there, the tube expands and secures the aneurysm with a mesh-like device.
4. Open surgical repair: In this surgical procedure, the surgeon makes an incision in the chest to access the aneurysm and repair it with a synthetic graft.
5. Heart transplantation: In severe cases of CAA that are not responding to other treatments, heart transplantation may be considered.

Lifestyle Changes:
While there is no cure for coronary artery aneurysms, making lifestyle changes can help manage symptoms and improve overall health. These changes may include:

1. Quitting smoking: Smoking is a major risk factor for CAA, so quitting can help reduce the risk of complications.
2. Exercise regularly: Regular physical activity can help improve cardiovascular health and reduce stress on the aneurysm.
3. Eating a healthy diet: A heart-healthy diet that is low in saturated fat, cholesterol, and sodium can help manage risk factors such as high blood pressure and high cholesterol.
4. Reducing stress: Stress can increase blood pressure and worsen CAA symptoms. Practicing stress-reducing techniques such as meditation or deep breathing can be helpful.
5. Limiting alcohol consumption: Excessive alcohol consumption can worsen CAA symptoms, so it is important to limit or avoid alcohol altogether.

In conclusion, coronary artery aneurysms are a serious condition that can lead to complications such as heart failure, arrhythmias, and stroke. While there is no cure for CAA, early detection and proper management can help reduce the risk of complications and improve quality of life. Treatment options may include medications, endovascular repair, open surgical repair, or heart transplantation, depending on the severity of the condition. Lifestyle changes such as quitting smoking, exercising regularly, eating a healthy diet, reducing stress, and limiting alcohol consumption can also help manage symptoms and improve cardiovascular health.

Some examples of the use of 'Death, Sudden, Cardiac' in medical contexts include:

1. Sudden cardiac death (SCD) is a major public health concern, affecting thousands of people each year in the United States alone. It is often caused by inherited heart conditions, such as hypertrophic cardiomyopathy or long QT syndrome.
2. The risk of sudden cardiac death is higher for individuals with a family history of heart disease or other pre-existing cardiovascular conditions.
3. Sudden cardiac death can be prevented by prompt recognition and treatment of underlying heart conditions, as well as by avoiding certain risk factors such as smoking, physical inactivity, and an unhealthy diet.
4. Cardiopulmonary resuscitation (CPR) and automated external defibrillators (AEDs) can be effective in restoring a normal heart rhythm during sudden cardiac death, especially when used promptly after the onset of symptoms.

During ventricular remodeling, the heart muscle becomes thicker and less flexible, leading to a decrease in the heart's ability to fill with blood and pump it out to the body. This can lead to shortness of breath, fatigue, and swelling in the legs and feet.

Ventricular remodeling is a natural response to injury, but it can also be exacerbated by factors such as high blood pressure, diabetes, and obesity. Treatment for ventricular remodeling typically involves medications and lifestyle changes, such as exercise and a healthy diet, to help manage symptoms and slow the progression of the condition. In some cases, surgery or other procedures may be necessary to repair or replace damaged heart tissue.

The process of ventricular remodeling is complex and involves multiple cellular and molecular mechanisms. It is thought to be driven by a variety of factors, including changes in gene expression, inflammation, and the activity of various signaling pathways.

Overall, ventricular remodeling is an important condition that can have significant consequences for patients with heart disease. Understanding its causes and mechanisms is crucial for developing effective treatments and improving outcomes for those affected by this condition.

1. Ischemic stroke: This is the most common type of stroke, accounting for about 87% of all strokes. It occurs when a blood vessel in the brain becomes blocked, reducing blood flow to the brain.
2. Hemorrhagic stroke: This type of stroke occurs when a blood vessel in the brain ruptures, causing bleeding in the brain. High blood pressure, aneurysms, and blood vessel malformations can all cause hemorrhagic strokes.
3. Transient ischemic attack (TIA): Also known as a "mini-stroke," a TIA is a temporary interruption of blood flow to the brain that lasts for a short period of time, usually less than 24 hours. TIAs are often a warning sign for a future stroke and should be taken seriously.

Stroke can cause a wide range of symptoms depending on the location and severity of the damage to the brain. Some common symptoms include:

* Weakness or numbness in the face, arm, or leg
* Difficulty speaking or understanding speech
* Sudden vision loss or double vision
* Dizziness, loss of balance, or sudden falls
* Severe headache
* Confusion, disorientation, or difficulty with memory

Stroke is a leading cause of long-term disability and can have a significant impact on the quality of life for survivors. However, with prompt medical treatment and rehabilitation, many people are able to recover some or all of their lost functions and lead active lives.

The medical community has made significant progress in understanding stroke and developing effective treatments. Some of the most important advances include:

* Development of clot-busting drugs and mechanical thrombectomy devices to treat ischemic strokes
* Improved imaging techniques, such as CT and MRI scans, to diagnose stroke and determine its cause
* Advances in surgical techniques for hemorrhagic stroke
* Development of new medications to prevent blood clots and reduce the risk of stroke

Despite these advances, stroke remains a significant public health problem. According to the American Heart Association, stroke is the fifth leading cause of death in the United States and the leading cause of long-term disability. In 2017, there were over 795,000 strokes in the United States alone.

There are several risk factors for stroke that can be controlled or modified. These include:

* High blood pressure
* Diabetes mellitus
* High cholesterol levels
* Smoking
* Obesity
* Lack of physical activity
* Poor diet

In addition to these modifiable risk factors, there are also several non-modifiable risk factors for stroke, such as age (stroke risk increases with age), family history of stroke, and previous stroke or transient ischemic attack (TIA).

The medical community has made significant progress in understanding the causes and risk factors for stroke, as well as developing effective treatments and prevention strategies. However, more research is needed to improve outcomes for stroke survivors and reduce the overall burden of this disease.

The exact cause of HCM is not fully understood, but it is thought to be related to a combination of genetic and environmental factors. Some people with HCM have a family history of the condition, and it is also more common in certain populations such as athletes and individuals with a history of hypertension or diabetes.

Symptoms of HCM can vary from person to person and may include shortness of breath, fatigue, palpitations, and chest pain. In some cases, HCM may not cause any symptoms at all and may be detected only through a physical examination or diagnostic tests such as an echocardiogram or electrocardiogram (ECG).

Treatment for HCM typically focuses on managing symptoms and reducing the risk of complications. This may include medications to reduce blood pressure, control arrhythmias, or improve heart function, as well as lifestyle modifications such as regular exercise and a healthy diet. In some cases, surgery or other procedures may be necessary to treat HCM.

Prognosis for individuals with HCM varies depending on the severity of the condition and the presence of any complications. With appropriate treatment and management, many people with HCM can lead active and fulfilling lives, but it is important to receive regular monitoring and care from a healthcare provider to manage the condition effectively.

There are several types of premature complexes, including:

1. Premature atrial complex (PAC): An extra heartbeat that originates in the atria, usually due to a rapid or irregular heart rate.
2. Premature ventricular complex (PVC): An extra heartbeat that originates in the ventricles, which can be more serious than PACs and may require further evaluation.
3. Premature nodal rhythm: A condition where the AV node (the electrical pathway between the atria and ventricles) fires prematurely, causing a rapid heart rate.

PCCs can be diagnosed using electrocardiography (ECG), which records the electrical activity of the heart. Treatment options for PCCs depend on the underlying cause and may include medications to regulate the heart rhythm, cardioversion (a procedure that restores a normal heart rhythm using electrical shock), or catheter ablation (a minimally invasive procedure that destroys the abnormal electrical pathway).

There are several types of cardiomyopathies, each with distinct characteristics and symptoms. Some of the most common forms of cardiomyopathy include:

1. Hypertrophic cardiomyopathy (HCM): This is the most common form of cardiomyopathy and is characterized by an abnormal thickening of the heart muscle, particularly in the left ventricle. HCM can lead to obstruction of the left ventricular outflow tract and can increase the risk of sudden death.
2. Dilated cardiomyopathy: This type of cardiomyopathy is characterized by a decrease in the heart's ability to pump blood effectively, leading to enlargement of the heart and potentially life-threatening complications such as congestive heart failure.
3. Restrictive cardiomyopathy: This type of cardiomyopathy is characterized by stiffness of the heart muscle, which makes it difficult for the heart to fill with blood. This can lead to shortness of breath and fatigue.
4. Left ventricular non-compaction (LVNC): This is a rare type of cardiomyopathy that occurs when the left ventricle does not properly compact, leading to reduced cardiac function and potentially life-threatening complications.
5. Cardiac amyloidosis: This is a condition in which abnormal proteins accumulate in the heart tissue, leading to stiffness and impaired cardiac function.
6. Right ventricular cardiomyopathy (RVCM): This type of cardiomyopathy is characterized by impaired function of the right ventricle, which can lead to complications such as pulmonary hypertension and heart failure.
7. Endocardial fibroelastoma: This is a rare type of cardiomyopathy that occurs when abnormal tissue grows on the inner lining of the heart, leading to reduced cardiac function and potentially life-threatening complications.
8. Cardiac sarcoidosis: This is a condition in which inflammatory cells accumulate in the heart, leading to impaired cardiac function and potentially life-threatening complications.
9. Hypertrophic cardiomyopathy (HCM): This is a condition in which the heart muscle thickens, leading to reduced cardiac function and potentially life-threatening complications such as arrhythmias and sudden death.
10. Hypokinetic left ventricular cardiomyopathy: This type of cardiomyopathy is characterized by decreased contraction of the left ventricle, leading to reduced cardiac function and potentially life-threatening complications such as heart failure.

It's important to note that some of these types of cardiomyopathy are more common in certain populations, such as hypertrophic cardiomyopathy being more common in young athletes. Additionally, some types of cardiomyopathy may have overlapping symptoms or co-occurring conditions, so it's important to work with a healthcare provider for an accurate diagnosis and appropriate treatment.

Recurrence can also refer to the re-emergence of symptoms in a previously treated condition, such as a chronic pain condition that returns after a period of remission.

In medical research, recurrence is often studied to understand the underlying causes of disease progression and to develop new treatments and interventions to prevent or delay its return.

In some cases, hyperemia can be a sign of a more serious underlying condition that requires medical attention. For example, if hyperemia is caused by an inflammatory or infectious process, it may lead to tissue damage or organ dysfunction if left untreated.

Hyperemia can occur in various parts of the body, including the skin, muscles, organs, and other tissues. It is often diagnosed through physical examination and imaging tests such as ultrasound, computed tomography (CT), or magnetic resonance imaging (MRI). Treatment for hyperemia depends on its underlying cause, and may include antibiotics, anti-inflammatory medications, or surgery.

In the context of dermatology, hyperemia is often used to describe a condition called erythema, which is characterized by redness and swelling of the skin due to increased blood flow. Erythema can be caused by various factors, such as sun exposure, allergic reactions, or skin infections. Treatment for erythema may include topical medications, oral medications, or other therapies depending on its underlying cause.

There are several key features of inflammation:

1. Increased blood flow: Blood vessels in the affected area dilate, allowing more blood to flow into the tissue and bringing with it immune cells, nutrients, and other signaling molecules.
2. Leukocyte migration: White blood cells, such as neutrophils and monocytes, migrate towards the site of inflammation in response to chemical signals.
3. Release of mediators: Inflammatory mediators, such as cytokines and chemokines, are released by immune cells and other cells in the affected tissue. These molecules help to coordinate the immune response and attract more immune cells to the site of inflammation.
4. Activation of immune cells: Immune cells, such as macrophages and T cells, become activated and start to phagocytose (engulf) pathogens or damaged tissue.
5. Increased heat production: Inflammation can cause an increase in metabolic activity in the affected tissue, leading to increased heat production.
6. Redness and swelling: Increased blood flow and leakiness of blood vessels can cause redness and swelling in the affected area.
7. Pain: Inflammation can cause pain through the activation of nociceptors (pain-sensing neurons) and the release of pro-inflammatory mediators.

Inflammation can be acute or chronic. Acute inflammation is a short-term response to injury or infection, which helps to resolve the issue quickly. Chronic inflammation is a long-term response that can cause ongoing damage and diseases such as arthritis, asthma, and cancer.

There are several types of inflammation, including:

1. Acute inflammation: A short-term response to injury or infection.
2. Chronic inflammation: A long-term response that can cause ongoing damage and diseases.
3. Autoimmune inflammation: An inappropriate immune response against the body's own tissues.
4. Allergic inflammation: An immune response to a harmless substance, such as pollen or dust mites.
5. Parasitic inflammation: An immune response to parasites, such as worms or fungi.
6. Bacterial inflammation: An immune response to bacteria.
7. Viral inflammation: An immune response to viruses.
8. Fungal inflammation: An immune response to fungi.

There are several ways to reduce inflammation, including:

1. Medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease-modifying anti-rheumatic drugs (DMARDs).
2. Lifestyle changes, such as a healthy diet, regular exercise, stress management, and getting enough sleep.
3. Alternative therapies, such as acupuncture, herbal supplements, and mind-body practices.
4. Addressing underlying conditions, such as hormonal imbalances, gut health issues, and chronic infections.
5. Using anti-inflammatory compounds found in certain foods, such as omega-3 fatty acids, turmeric, and ginger.

It's important to note that chronic inflammation can lead to a range of health problems, including:

1. Arthritis
2. Diabetes
3. Heart disease
4. Cancer
5. Alzheimer's disease
6. Parkinson's disease
7. Autoimmune disorders, such as lupus and rheumatoid arthritis.

Therefore, it's important to manage inflammation effectively to prevent these complications and improve overall health and well-being.

Types: There are several types of brain infarction, including:

1. Cerebral infarction: This type of infarction occurs when there is a blockage or obstruction in the blood vessels that supply the cerebrum, which is the largest part of the brain.
2. Cerebellar infarction: This type of infarction occurs when there is a blockage or obstruction in the blood vessels that supply the cerebellum, which is located at the base of the brain.
3. Brain stem infarction: This type of infarction occurs when there is a blockage or obstruction in the blood vessels that supply the brain stem, which is the part of the brain that controls vital functions such as breathing, heart rate, and blood pressure.

Symptoms: The symptoms of brain infarction can vary depending on the location and size of the affected area, but common symptoms include:

1. Sudden weakness or numbness in the face, arm, or leg
2. Sudden confusion or trouble speaking or understanding speech
3. Sudden difficulty seeing or blindness
4. Sudden difficulty walking or loss of balance
5. Sudden severe headache
6. Difficulty with coordination and movement
7. Slurred speech
8. Vision changes
9. Seizures

Diagnosis: Brain infarction is typically diagnosed using a combination of physical examination, medical history, and imaging tests such as CT or MRI scans. Other diagnostic tests may include blood tests to check for signs of infection or blood clotting abnormalities, and an electroencephalogram (EEG) to measure the electrical activity of the brain.

Treatment: The treatment of brain infarction depends on the underlying cause, but common treatments include:

1. Medications: To control symptoms such as high blood pressure, seizures, and swelling in the brain.
2. Endovascular therapy: A minimally invasive procedure to open or remove blockages in the blood vessels.
3. Surgery: To relieve pressure on the brain or repair damaged blood vessels.
4. Rehabilitation: To help regain lost function and improve quality of life.

Prognosis: The prognosis for brain infarction depends on the location and size of the affected area, as well as the promptness and effectiveness of treatment. In general, the earlier treatment is received, the better the outcome. However, some individuals may experience long-term or permanent disability, or even death.

The effects of hypoxia-ischemia on the brain can vary depending on the severity and duration of the insult, but may include:

* Cellular damage and death
* Inflammation and oxidative stress
* Neurotransmitter imbalances
* Blood-brain barrier disruption
* White matter degeneration

The long-term consequences of hypoxia-ischemia, brain may include cognitive impairments such as memory loss, attention deficits, and language difficulties. Behavioral changes, such as depression, anxiety, and mood swings, may also occur. In severe cases, the condition can lead to permanent vegetative state or death.

The diagnosis of hypoxia-ischemia, brain is based on a combination of clinical evaluation, laboratory tests, and imaging studies such as CT or MRI scans. Treatment options may include supportive care, medications, and rehabilitation therapies to address cognitive and behavioral impairments. In some cases, surgical interventions may be necessary to relieve pressure or restore blood flow to the affected areas.

Overall, hypoxia-ischemia, brain is a serious medical condition that requires prompt recognition and appropriate treatment to minimize long-term cognitive and functional impairments.

Tachycardia, ventricular can be classified into several types based on its duration and the presence of other symptoms. These include:

1. Paroxysmal ventricular tachycardia (PVT): This is a rapid heart rate that occurs in episodes lasting less than 30 seconds and may be accompanied by palpitations, shortness of breath, or dizziness.
2. Sustained ventricular tachycardia: This is a rapid heart rate that persists for more than 30 seconds and may require medical intervention to return the heart to normal rhythm.
3. Ventricular fibrillation (VF): This is a life-threatening condition in which the ventricles are unable to pump blood effectively due to rapid, disorganized electrical activity.

Symptoms of tachycardia, ventricular may include:

* Palpitations or rapid heartbeat
* Shortness of breath
* Dizziness or lightheadedness
* Chest pain or discomfort
* Fatigue or weakness

Diagnosis of tachycardia, ventricular is typically made based on a physical examination, medical history, and results of diagnostic tests such as electrocardiogram (ECG), echocardiogram, or stress test. Treatment options may include medications to regulate heart rhythm, cardioversion to restore normal heart rhythm, and in some cases, implantation of a cardioverter-defibrillator (ICD) to prevent sudden death.

In summary, tachycardia, ventricular is a rapid heart rate that originates in the ventricles and can be caused by a variety of conditions. It is important to seek medical attention if symptoms persist or worsen over time. With proper diagnosis and treatment, it is possible to manage the condition and improve quality of life.

1. Heart Disease: High blood sugar levels can damage the blood vessels and increase the risk of heart disease, which includes conditions like heart attacks, strokes, and peripheral artery disease.
2. Kidney Damage: Uncontrolled diabetes can damage the kidneys over time, leading to chronic kidney disease and potentially even kidney failure.
3. Nerve Damage: High blood sugar levels can damage the nerves in the body, causing numbness, tingling, and pain in the hands and feet. This is known as diabetic neuropathy.
4. Eye Problems: Diabetes can cause changes in the blood vessels of the eyes, leading to vision problems and even blindness. This is known as diabetic retinopathy.
5. Infections: People with diabetes are more prone to developing skin infections, urinary tract infections, and other types of infections due to their weakened immune system.
6. Amputations: Poor blood flow and nerve damage can lead to amputations of the feet or legs if left untreated.
7. Cognitive Decline: Diabetes has been linked to an increased risk of cognitive decline and dementia.
8. Sexual Dysfunction: Men with diabetes may experience erectile dysfunction, while women with diabetes may experience decreased sexual desire and vaginal dryness.
9. Gum Disease: People with diabetes are more prone to developing gum disease and other oral health problems due to their increased risk of infection.
10. Flu and Pneumonia: Diabetes can weaken the immune system, making it easier to catch the flu and pneumonia.

It is important for people with diabetes to manage their condition properly to prevent or delay these complications from occurring. This includes monitoring blood sugar levels regularly, taking medication as prescribed by a doctor, and following a healthy diet and exercise plan. Regular check-ups with a healthcare provider can also help identify any potential complications early on and prevent them from becoming more serious.

There are two main types of heart failure:

1. Left-sided heart failure: This occurs when the left ventricle, which is the main pumping chamber of the heart, becomes weakened and is unable to pump blood effectively. This can lead to congestion in the lungs and other organs.
2. Right-sided heart failure: This occurs when the right ventricle, which pumps blood to the lungs, becomes weakened and is unable to pump blood effectively. This can lead to congestion in the body's tissues and organs.

Symptoms of heart failure may include:

* Shortness of breath
* Fatigue
* Swelling in the legs, ankles, and feet
* Swelling in the abdomen
* Weight gain
* Coughing up pink, frothy fluid
* Rapid or irregular heartbeat
* Dizziness or lightheadedness

Treatment for heart failure typically involves a combination of medications and lifestyle changes. Medications may include diuretics to remove excess fluid from the body, ACE inhibitors or beta blockers to reduce blood pressure and improve blood flow, and aldosterone antagonists to reduce the amount of fluid in the body. Lifestyle changes may include a healthy diet, regular exercise, and stress reduction techniques. In severe cases, heart failure may require hospitalization or implantation of a device such as an implantable cardioverter-defibrillator (ICD) or a left ventricular assist device (LVAD).

It is important to note that heart failure is a chronic condition, and it requires ongoing management and monitoring to prevent complications and improve quality of life. With proper treatment and lifestyle changes, many people with heart failure are able to manage their symptoms and lead active lives.

Some examples of pathologic constrictions include:

1. Stenosis: A narrowing or constriction of a blood vessel or other tubular structure, often caused by the buildup of plaque or scar tissue.
2. Asthma: A condition characterized by inflammation and constriction of the airways, which can make breathing difficult.
3. Esophageal stricture: A narrowing of the esophagus that can cause difficulty swallowing.
4. Gastric ring constriction: A narrowing of the stomach caused by a band of tissue that forms in the upper part of the stomach.
5. Anal fissure: A tear in the lining of the anus that can cause pain and difficulty passing stools.

Pathologic constrictions can be caused by a variety of factors, including inflammation, infection, injury, or genetic disorders. They can be diagnosed through imaging tests such as X-rays, CT scans, or endoscopies, and may require surgical treatment to relieve symptoms and improve function.

Hypothermia can be mild, moderate, or severe. Mild hypothermia is characterized by shivering and a body temperature of 95 to 97 degrees Fahrenheit (32 to 36.1 degrees Celsius). Moderate hypothermia has a body temperature of 82 to 94 degrees Fahrenheit (28 to 34 degrees Celsius), and the person may appear lethargic, drowsy, or confused. Severe hypothermia is characterized by a body temperature below 82 degrees Fahrenheit (28 degrees Celsius) and can lead to coma and even death if not treated promptly.

Treatment for hypothermia typically involves warming the person up slowly, using blankets or heating pads, and providing warm fluids to drink. In severe cases, medical professionals may use a specialized warm water bath or apply warm packs to specific areas of the body.

Preventing hypothermia is important, especially in cold weather conditions. This can be done by dressing appropriately for the weather, staying dry and avoiding wet clothing, eating regularly to maintain energy levels, and seeking shelter if you become stranded or lost. It's also essential to recognize the signs of hypothermia early on so that treatment can begin promptly.

Examples of syndromes include:

1. Down syndrome: A genetic disorder caused by an extra copy of chromosome 21 that affects intellectual and physical development.
2. Turner syndrome: A genetic disorder caused by a missing or partially deleted X chromosome that affects physical growth and development in females.
3. Marfan syndrome: A genetic disorder affecting the body's connective tissue, causing tall stature, long limbs, and cardiovascular problems.
4. Alzheimer's disease: A neurodegenerative disorder characterized by memory loss, confusion, and changes in personality and behavior.
5. Parkinson's disease: A neurological disorder characterized by tremors, rigidity, and difficulty with movement.
6. Klinefelter syndrome: A genetic disorder caused by an extra X chromosome in males, leading to infertility and other physical characteristics.
7. Williams syndrome: A rare genetic disorder caused by a deletion of genetic material on chromosome 7, characterized by cardiovascular problems, developmental delays, and a distinctive facial appearance.
8. Fragile X syndrome: The most common form of inherited intellectual disability, caused by an expansion of a specific gene on the X chromosome.
9. Prader-Willi syndrome: A genetic disorder caused by a defect in the hypothalamus, leading to problems with appetite regulation and obesity.
10. Sjogren's syndrome: An autoimmune disorder that affects the glands that produce tears and saliva, causing dry eyes and mouth.

Syndromes can be diagnosed through a combination of physical examination, medical history, laboratory tests, and imaging studies. Treatment for a syndrome depends on the underlying cause and the specific symptoms and signs presented by the patient.

There are two types of heart arrest:

1. Asystole - This is when the heart stops functioning completely and there is no electrical activity in the heart.
2. Pulseless ventricular tachycardia or fibrillation - This is when the heart is still functioning but there is no pulse and the rhythm is abnormal.

Heart arrest can be diagnosed through various tests such as electrocardiogram (ECG), blood tests, and echocardiography. Treatment options for heart arrest include cardiopulmonary resuscitation (CPR), defibrillation, and medications to restore a normal heart rhythm.

In severe cases of heart arrest, the patient may require advanced life support measures such as mechanical ventilation and cardiac support devices. The prognosis for heart arrest is generally poor, especially if it is not treated promptly and effectively. However, with proper treatment and support, some patients can recover and regain normal heart function.

It is important to note that stable angina is different from unstable angina, which is a more severe and potentially life-threatening condition that can occur when there is a sudden blockage in one of the coronary arteries. Unlike stable angina, unstable angina can cause severe chest pain or discomfort that can radiate to other parts of the body and can be accompanied by other symptoms such as shortness of breath, nausea, and vomiting.

Stable angina is often described as a squeezing, pressing, or aching sensation in the chest that can be triggered by physical activity or emotional stress. The pain typically subsides within a few minutes after resting or taking medication. People with stable angina may also experience pain in their arms, shoulders, neck, jaw, or back.

Stable angina is usually diagnosed through a combination of physical examination, medical history, and diagnostic tests such as electrocardiogram (ECG), stress test, and blood tests. Treatment for stable angina typically involves medications to reduce the workload on the heart, improve blood flow, and manage pain. Lifestyle changes such as regular exercise, a healthy diet, and stress management techniques can also help manage the condition. In some cases, surgery may be necessary to open or bypass blocked coronary arteries.

In summary, stable angina is a predictable and manageable type of chest pain that occurs when the heart muscle is not receiving enough oxygen-rich blood due to blockages in the coronary arteries. It can be treated with medication, lifestyle changes, and in some cases, surgery. It is important to seek medical attention if symptoms persist or worsen over time, as this could indicate a more severe condition such as unstable angina or a heart attack.

There are several types of ventricular dysfunction, including:

1. Left ventricular dysfunction: This occurs when the left ventricle, which is the main pumping chamber of the heart, becomes weakened or impaired. This can lead to reduced cardiac output and can increase the risk of heart failure.
2. Right ventricular dysfunction: This occurs when the right ventricle, which pumps blood into the lungs, becomes weakened or impaired. This can lead to pulmonary hypertension and other complications.
3. Biventricular dysfunction: This occurs when both the left and right ventricles become weakened or impaired. This can lead to severe cardiac impairment and increased risk of heart failure.

Ventricular dysfunction can be diagnosed through a variety of tests, including echocardiography, stress testing, and cardiac magnetic resonance imaging (MRI). Treatment options depend on the underlying cause of the dysfunction and may include medications, lifestyle changes, or surgical interventions. In some cases, implantable devices such as pacemakers or defibrillators may be recommended to help regulate the heart rhythm and improve function.

There are two types of hypertension:

1. Primary Hypertension: This type of hypertension has no identifiable cause and is also known as essential hypertension. It accounts for about 90% of all cases of hypertension.
2. Secondary Hypertension: This type of hypertension is caused by an underlying medical condition or medication. It accounts for about 10% of all cases of hypertension.

Some common causes of secondary hypertension include:

* Kidney disease
* Adrenal gland disorders
* Hormonal imbalances
* Certain medications
* Sleep apnea
* Cocaine use

There are also several risk factors for hypertension, including:

* Age (the risk increases with age)
* Family history of hypertension
* Obesity
* Lack of exercise
* High sodium intake
* Low potassium intake
* Stress

Hypertension is often asymptomatic, and it can cause damage to the blood vessels and organs over time. Some potential complications of hypertension include:

* Heart disease (e.g., heart attacks, heart failure)
* Stroke
* Kidney disease (e.g., chronic kidney disease, end-stage renal disease)
* Vision loss (e.g., retinopathy)
* Peripheral artery disease

Hypertension is typically diagnosed through blood pressure readings taken over a period of time. Treatment for hypertension may include lifestyle changes (e.g., diet, exercise, stress management), medications, or a combination of both. The goal of treatment is to reduce the risk of complications and improve quality of life.

There are many different types of ANS diseases, including:

1. Dysautonomia: a general term that refers to dysfunction of the autonomic nervous system.
2. Postural orthostatic tachycardia syndrome (POTS): a condition characterized by rapid heart rate and other symptoms that occur upon standing.
3. Neurocardiogenic syncope: a form of fainting caused by a sudden drop in blood pressure.
4. Multiple system atrophy (MSA): a progressive neurodegenerative disorder that affects the autonomic nervous system and other parts of the brain.
5. Parkinson's disease: a neurodegenerative disorder that can cause autonomic dysfunction, including constipation, urinary incontinence, and erectile dysfunction.
6. Dopamine deficiency: a condition characterized by low levels of the neurotransmitter dopamine, which can affect the ANS and other body systems.
7. Autonomic nervous system disorders associated with autoimmune diseases, such as Guillain-Barré syndrome and lupus.
8. Trauma: physical or emotional trauma can sometimes cause dysfunction of the autonomic nervous system.
9. Infections: certain infections, such as Lyme disease, can affect the autonomic nervous system.
10. Genetic mutations: some genetic mutations can affect the functioning of the autonomic nervous system.

Treatment for ANS diseases depends on the specific condition and its underlying cause. In some cases, medication may be prescribed to regulate heart rate, blood pressure, or other bodily functions. Lifestyle changes, such as regular exercise and stress management techniques, can also be helpful in managing symptoms. In severe cases, surgery may be necessary to correct anatomical abnormalities or repair damaged nerves.

Type 2 diabetes can be managed through a combination of diet, exercise, and medication. In some cases, lifestyle changes may be enough to control blood sugar levels, while in other cases, medication or insulin therapy may be necessary. Regular monitoring of blood sugar levels and follow-up with a healthcare provider are important for managing the condition and preventing complications.

Common symptoms of type 2 diabetes include:

* Increased thirst and urination
* Fatigue
* Blurred vision
* Cuts or bruises that are slow to heal
* Tingling or numbness in the hands and feet
* Recurring skin, gum, or bladder infections

If left untreated, type 2 diabetes can lead to a range of complications, including:

* Heart disease and stroke
* Kidney damage and failure
* Nerve damage and pain
* Eye damage and blindness
* Foot damage and amputation

The exact cause of type 2 diabetes is not known, but it is believed to be linked to a combination of genetic and lifestyle factors, such as:

* Obesity and excess body weight
* Lack of physical activity
* Poor diet and nutrition
* Age and family history
* Certain ethnicities (e.g., African American, Hispanic/Latino, Native American)
* History of gestational diabetes or delivering a baby over 9 lbs.

There is no cure for type 2 diabetes, but it can be managed and controlled through a combination of lifestyle changes and medication. With proper treatment and self-care, people with type 2 diabetes can lead long, healthy lives.

1. Migraine: A severe, recurring headache that can last for hours to days, often accompanied by sensitivity to light, sound, and nausea.
2. Tension-type headache: A common type of headache characterized by a dull, aching pain on both sides of the head, often associated with muscle tension.
3. Cluster headache: A severe, one-sided headache that can occur multiple times a day and last for weeks or months.
4. Trigeminal autonomic cephalalgias (TACs): A group of rare but severely painful headaches that are often associated with facial swelling and tearing.

Primary headache disorders can be challenging to diagnose and manage, as they can have overlapping symptoms and may not be easily distinguishable from other conditions. However, there are several medications and therapies available to help manage these disorders and improve quality of life for individuals affected by them.

Brain hypoxia is a serious medical condition that requires prompt treatment to prevent long-term damage and improve outcomes for patients. Treatment options may include oxygen therapy, medications to improve blood flow to the brain, and surgery to remove any blockages or obstructions in blood vessels.

There are several causes of hypotension, including:

1. Dehydration: Loss of fluids and electrolytes can cause a drop in blood pressure.
2. Blood loss: Losing too much blood can lead to hypotension.
3. Medications: Certain medications, such as diuretics and beta-blockers, can lower blood pressure.
4. Heart conditions: Heart failure, cardiac tamponade, and arrhythmias can all cause hypotension.
5. Endocrine disorders: Hypothyroidism (underactive thyroid) and adrenal insufficiency can cause low blood pressure.
6. Vasodilation: A condition where the blood vessels are dilated, leading to low blood pressure.
7. Sepsis: Severe infection can cause hypotension.

Symptoms of hypotension can include:

1. Dizziness and lightheadedness
2. Fainting or passing out
3. Weakness and fatigue
4. Confusion and disorientation
5. Pale, cool, or clammy skin
6. Fast or weak pulse
7. Shortness of breath
8. Nausea and vomiting

If you suspect that you or someone else is experiencing hypotension, it is important to seek medical attention immediately. Treatment will depend on the underlying cause of the condition, but may include fluids, electrolytes, and medication to raise blood pressure. In severe cases, hospitalization may be necessary.

The Myocardial Ischaemia National Audit Project (MINAP) (previously known as the "Myocardial Infarction National Audit Database ... This allowed clinicians to examine the management of myocardial infarction within their hospitals against targets specified by ... ") began in late 1998 when a broadly based steering group developed a dataset for acute myocardial infarction (AMI). ...
Myocardial ischemia. Mayo Clinic (25 July 2015). Retrieved on 28 May 2016. Zvejniece, L; Svalbe, B; Makrecka, M; Liepinsh, E; ... specifically in myocardial mitochondria) to survive ischemic stress conditions. This is done by adapting myocardial cells to ... These heart problems may sometimes lead to ischemia, a condition where too little blood flows to the organs in the body, ... "Meldonium cannot improve athletic performance, but it can stop tissue damage in the case of ischemia", the lack of blood flow ...
... , myocardial ischemia, or cardiac ischemia, is a medical term for a reduced blood flow in the coronary ... "Silent Ischemia - Myocardial Ischemia Without Angina , Beaumont , Beaumont Health". www.beaumont.org. Retrieved 2022-05-28. " ... February 2018). "Mental Stress-Induced-Myocardial Ischemia in Young Patients With Recent Myocardial Infarction: Sex Differences ... "Myocardial ischemia". Mayo Clinic. Retrieved 2019-11-29. Potochny, Evy. "Cardiac Ischemia Symptoms." LiveStrong. Demand Media, ...
Silent Myocardial Ischemia. Springer: 29-36. doi:10.1007/978-3-642-69589-6_6. ISBN 978-3-540-13193-9. The SoS Investigators: ... Knight, Charles J. (1 March 2000). "Five years of percutaneous transluminal septal myocardial ablation". Heart. 83 (3): 255-256 ... Sigwart, U. (22 July 1995). "Non-surgical myocardial reduction for hypertrophic obstructive cardiomyopathy". Lancet. 346 (8969 ...
Murphy BP, Stanton T, Dunn FG (May 2009). "Hypertension and myocardial ischemia". The Medical Clinics of North America. 93 (3 ...
Murphy BP, Stanton T, Dunn FG (May 2009). "Hypertension and myocardial ischemia". The Medical Clinics of North America. 93 (3 ... and retinal ischemia. These changes are manifested in the retina as microaneurysms, hemorrhages, hard exudates, and cotton-wool ... cerebral ischemia, hemorrhagic or thrombotic stroke, seizure disorder, mass lesions, pseudotumor cerebri, delirium tremens, ... larger vessel or multiple lacunar infarcts due to occlusive small vessel disease resulting in subcortical white matter ischemia ...
Murphy BP, Stanton T, Dunn FG (May 2009). "Hypertension and myocardial ischemia". The Medical Clinics of North America. 93 (3 ... These relatively narrow vessels are commonly affected by atherosclerosis and can become blocked, causing angina or myocardial ... Cardiac disorders such as coronary heart disease, including myocardial infarction, heart failure, cardiomyopathy, and ... myocardial infarction, and is one of the causes of sudden cardiac death. It is within the group of cardiovascular diseases of ...
... worsening myocardial ischemia, acute myocardial infarction, and worsening congestive heart failure. Amrinone has good ... May increase myocardial ischemia. Blood pressure, pulse, and ECG should be constantly monitored. Amrinone should only be ... There is a net decrease in myocardial wall tension, and O2 consumption when using amrinone. Amrinone also has beneficial ... Carabello B.A. (1980). "Effects of Amrinone on Myocardial Energy Metabolism and Hemodynamics in Patients with Severe Congestive ...
Michel, Thomas (2006) [1941]. "Treatment of Myocardial Ischemia". In Laurence L. Brunton; John S. Lazo; Keith L. Parker (eds ... primary percutaneous intervention early after ST-elevation myocardial infarction: the WEST (Which Early ST-elevation myocardial ... Ischemia, a large trial of 5,179 participants followed for a median of three and a half years that was funded by the US federal ... Ischemia did find that stents seemed to help some patients with angina, however. Several other clinical trials have been ...
"Myocardial ischemia - Symptoms and causes". Mayo Clinic. Retrieved 2021-10-27. World Health Organization Department of Health ... Ischemia of the small bowel is called mesenteric ischemia. Brain ischemia is insufficient blood flow to the brain, and can be ... Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of ... For example, patients with myocardial ischemia have a decreased blood flow to the heart and are prescribed with medications ...
"Myocardial Ischemia and Transfusion Pilot". {{cite journal}}: Cite journal requires ,journal= (help) "RFA-HL-15-015: Multi-Site ... Myocardial Ischemia and Transfusion: MINT is a multicenter randomized clinical trial comparing red blood cell transfusion ... The trial will enroll 3500 hospitalized patients diagnosed with myocardial infarction who are anemic (have blood counts less ... strategies for patients who have had a myocardial infarction and are anemic. ...
Noninvasive Imaging of Myocardial Ischemia. New York: Springer-Verlag. p. 93. doi:10.1007/1-84628-156-3_6. ISBN 978-1-84628-027 ...
"Myocardial ischemia - Symptoms and causes". Mayo Clinic. Retrieved 5 February 2022. "Ischemic Heart Disease". National Heart, ... Coronary artery disease (CAD), also called coronary heart disease (CHD), ischemic heart disease (IHD), myocardial ischemia, or ... "Percutaneous coronary intervention outcomes in patients with stable obstructive coronary artery disease and myocardial ischemia ... The heart's muscle cells may die from lack of oxygen and this is called a myocardial infarction (commonly referred to as a ...
Myocardial Ischemia and Lipid Metabolism. New York: Plenum Press. ISBN 978-1-4684-4865-8. Ferrari, R.; Di Mauro, S.; Sherwood, ... dedicating himself to improving the clinical treatment of myocardial ischaemia and heart failure, while placing a particular ... Ferrari, R.; Rizzo, P. (2014-08-02). "The Notch pathway: a novel target for myocardial remodelling therapy?". European Heart ... Ferrari, R (2001-05-15). "Favouring myocardial viability to necrosis: a challenge in ischaemic heart disease with prognostic ...
... (MI) refers to tissue death (infarction) of the heart muscle (myocardium) caused by ischaemia, the lack ... In addition to myocardial infarction, other causes include angina, insufficient blood supply (ischemia) to the heart muscles ... Typically, chest pain because of ischemia, be it unstable angina or myocardial infarction, lessens with the use of ... Buja LM (July 2005). "Myocardial ischemia and reperfusion injury". Cardiovascular Pathology. 14 (4): 170-5. doi:10.1016/j. ...
Hollander, Judd (December 28, 2011). "Update on Cocaine Myocardial Ischemia". Archived from the original on January 11, 2017. ... and myocardial contractility, which are major determinants of myocardial oxygen demand. Cocaine and its metabolites may cause ... This can lead to death from acute myocardial infarction, acute respiratory failure (i.e., hypoxemia, with or without ... Freeman, Kalev; Feldman, James A. (2008-02-01). "Cocaine, myocardial infarction, and beta-blockers: time to rethink the ...
Calise, J; Powell, S. R. (2013). "The ubiquitin proteasome system and myocardial ischemia". AJP: Heart and Circulatory ...
Calise J, Powell SR (Feb 2013). "The ubiquitin proteasome system and myocardial ischemia". American Journal of Physiology. ...
Calise J, Powell SR (Feb 2013). "The ubiquitin proteasome system and myocardial ischemia". American Journal of Physiology. ...
Calise J, Powell SR (Feb 2013). "The ubiquitin proteasome system and myocardial ischemia". American Journal of Physiology. ...
Calise J, Powell SR (February 2013). "The ubiquitin proteasome system and myocardial ischemia". American Journal of Physiology ...
Calise J, Powell SR (Feb 2013). "The ubiquitin proteasome system and myocardial ischemia". American Journal of Physiology. ...
Calise J, Powell SR (Feb 2013). "The ubiquitin proteasome system and myocardial ischemia". American Journal of Physiology. ...
Calise J, Powell SR (Feb 2013). "The ubiquitin proteasome system and myocardial ischemia". American Journal of Physiology. ...
Calise J, Powell SR (Feb 2013). "The ubiquitin proteasome system and myocardial ischemia". American Journal of Physiology. ...
Yasumasa Kanada, 70, Japanese mathematician, myocardial ischemia. Jack Kramer, 80, Norwegian footballer (Vålerenga, national ...
Calise J, Powell SR (Feb 2013). "The ubiquitin proteasome system and myocardial ischemia". American Journal of Physiology. ...
Calise J, Powell SR (Feb 2013). "The ubiquitin proteasome system and myocardial ischemia". American Journal of Physiology. ...
Calise J, Powell SR (February 2013). "The ubiquitin proteasome system and myocardial ischemia". American Journal of Physiology ...
Calise J, Powell SR (Feb 2013). "The ubiquitin proteasome system and myocardial ischemia". American Journal of Physiology. ...
429 Ill-defined descriptions and complications of heart disease 429.0 Myocarditis unspecified 429.1 Myocardial degeneration ... Cerebral embolism without cerebral infarction 434.11 Cerebral embolism with cerebral infarction 435 Transient cerebral ischemia ... papillary muscle 429.7 Certain sequelae of myocardial infarction not elsewhere classified 429.71 Certain sequelae of myocardial ... benign 410 Acute myocardial infarction 410.0 MI, acute, anterolateral 410.1 MI, acute, anterior, NOS 410.2 MI, acute, ...
30 Forgot medication Arrhythmia/ Anaemia Ischemia/ Infarction/ Infection Lifestyle: taken too much salt Upregulation of CO: ... Hypovolemia Myocardial infarction Electrolyte derangements Drugs ELEVATION:p. 34 Electrolytes LBBB Early repolarization ...
Events reported have included coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular ...
... left ventricular repair and remodelling following ischemia, and acute and chronic heart failure. Prof. Dr. Johann Bauersachs ... "Molecular Imaging Identifies Fibroblast Activation Beyond the Infarct Region After Acute Myocardial Infarction". Journal of the ... Molecular Imaging Identifies Fibroblast Activation Beyond the Infarct Region After Acute Myocardial Infarction. Risk ...
1999 H3 receptor cloned 2000 H3 receptors called "new frontier in myocardial ischemia" 2002 H3(-/-) mice (mice that do not have ... Levi R, Smith NC (Mar 2000). "Histamine H(3)-receptors: a new frontier in myocardial ischemia" (abstract). The Journal of ... of histamine H3 receptors inhibits carrier-mediated norepinephrine release in a human model of protracted myocardial ischemia ...
H-FABP is a sensitive biomarker for myocardial infarction and can be detected in the blood within one to three hours of the ... "Release of fatty acid-binding protein from isolated rat heart subjected to ischemia and reperfusion or to the calcium paradox ... Wodzig KW, Kragten JA, Hermens WT, Glatz JF, van Dieijen-Visser MP (Mar 1997). "Estimation of myocardial infarct size from ... H-FABP is recommended to be measured with troponin to identify myocardial infarction and acute coronary syndrome in patients ...
During ischemia reperfusion, ROS release substantially contribute to the cell damage and death via a direct effect on the cell ... Braunwald E, Kloner RA (Nov 1985). "Myocardial reperfusion: a double-edged sword?". The Journal of Clinical Investigation. 76 ( ... Most notably, Enodnuclease G is pivotal during oxidative stress by ischemia-reperfusion injury, specifically in the myocardium ... such as ischemia-reperfusion injury during heart attacks and strokes) or during developments and processes in cancer, an ...
"Nerve growth factor reduces myocardial ischemia/reperfusion injury in rat hearts". Journal of Basic and Clinical Physiology and ... "Ischemia"-Stressed PC12 Pheochromocytoma Cells". Brain Sciences. 8 (2): 32. doi:10.3390/brainsci8020032. PMC 5836051. PMID ... He developed and investigated different neuroprotective compounds and approaches towards neuronal ischemia in stroke, and ...
Myocardial Ischemia/Infarction: A heart attack is often caused by a significant build-up of plaque (atherosclerosis) in the ... Toxic Myocarditis: Even in patients without myocardial damage, excessive catecholamines can result in abnormal ST changes on an ... Patients with pheochromocytoma present with myocardial infarctions despite an overall lack of plaque build-up, indicating a ... She quickly developed a hypertensive crisis leading to shock, myocardial infarction, heart failure, and dense right hemiplegia ...
A fatal course usually involves gastrointestinal bleeding, infection, myocardial infarction, and/or kidney failure. In case of ... mesenteric ischemia, and bowel perforation. Abdominal pain may also be seen.[citation needed] Musculoskeletal system: Muscle ... myocardial infarction, or stroke. PAN may affect nearly every organ system and thus can present with a broad array of signs and ...
This is called a perfusion defect and usually represents myocardial ischaemia. It may be seen on both the rest and stress scans ... CMR perfusion is increasingly used in cardiac imaging to test for inducible myocardial ischaemia and has been well validated ... 2000). "Noninvasive detection of myocardial ischemia from perfusion reserve based on cardiovascular magnetic resonance". ... If it is only seen on the stress scan it is called an area of inducible perfusion defect (ischaemia). The position in the left ...
... one Exhibited Efficient Cardioprotection in a Myocardial Ischemia (MI) Mouse Model". Journal of Medicinal Chemistry. 61 (24): ...
In 85% of cases it is due to asthma, pneumonia, cardiac ischemia, interstitial lung disease, congestive heart failure, chronic ... The most common cardiovascular causes are acute myocardial infarction and congestive heart failure while common pulmonary ... Risk factors for acute decompensation include high dietary salt intake, medication noncompliance, cardiac ischemia, abnormal ... myocardial infarction, pulmonary embolism, or pneumothorax. Patients with COPD and idiopathic pulmonary fibrosis (IPF) have a ...
"SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac ... "Short-term disruption of diurnal rhythms after murine myocardial infarction adversely affects long-term myocardial structure ... or reducing adverse light at night in hospitals may improve patient outcomes post-myocardial infarction (heart attack). 2) " ... "Day-night dependence of gene expression and inflammatory responses in the remodeling murine heart post-myocardial infarction". ...
In ischemia, the major damage to the cardiac myocyte, due to hypoxia, is seen following the reperfusion of blood. High ... Létienne R, Bel L, Bessac AM, Vacher B, Le Grand B (December 2009). "Myocardial protection by F 15845, a persistent sodium ... F15845 is a cardiac drug proposed to have beneficial effects for the treatment of angina pectoris, arrhythmias and ischemia by ... September 2010). "Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias". British ...
Visceral structures (e.g., the heart, liver and intestines) are highly sensitive to stretch, ischemia and inflammation, but ... For example, chest pain described as extreme heaviness may indicate myocardial infarction, while chest pain described as ... Is this patient having a myocardial infarction?". JAMA. 280 (14): 1256-63. doi:10.1001/jama.280.14.1256. PMID 9786377. Slater ...
Early reports indicated that Cherepanov suffered from chronic myocardial ischemia, and many reports questioned Avangard Omsk's ... elite athlete would suffer from an undiagnosed form of ischemia, particularly when considering the medical testing he underwent ...
... causing it to die by ischemia, similar to what happens in an ischemic stroke. Because it is an indirect effect of the treatment ... myocardial fibrosis, valvular heart disease, coronary artery disease, heart arrhythmia and peripheral artery disease. Radiation ...
These include, but are not limited to, hypotension, tachycardia, angina, syncope, weakness, confusion, stroke, myocardial ... specifically a bleeding diathesis Anal fissures Rectal foreign bodies Mesenteric ischemia NSAIDs Entamoeba histolytica ... unstable angina or a myocardial infarction) within 90 days of the LGIB event. Individuals at high risk of another heart attack ...
In patients with acute myocardial infarction complicated by cardiogenic shock, haemodynamic support with the Impella device had ... limb ischaemia, and bleeding requiring surgical intervention (2.6%). Valvular complications included aortic and mitral valve ... A propensity-matched comparison of patients receiving mechanical circulatory support (MCS) for myocardial infarction-related ... and myocardial oxygen demand. Second, it increases mean arterial pressure, diastolic pressure, and cardiac output, improving ...
... limits myocardial infarct size even when administered after onset of ischemia". Circulation. 98 (9): 899-905. doi:10.1161/01. ... "Protein phosphatase inhibitors calyculin A and fostriecin protect rabbit cardiomyocytes in late ischemia". Journal of Molecular ...
Obame FN, Zini R, Souktani R, Berdeaux A, Morin D (October 2007). "Peripheral benzodiazepine receptor-induced myocardial ... Solhjoo S, O'Rourke B (January 2015). "Mitochondrial instability during regional ischemia-reperfusion underlies arrhythmias in ...
Post-myocardial complications occur after a period of ischemia, these changes can be seen in gross tissue changes and ... Myocardial rupture is most common three to seven days after myocardial infarction, commonly of small degree, but may occur one ... A myocardial infarction may compromise the function of the heart as a pump for the circulation, a state called heart failure. ... Myocardial infarction complications may occur immediately following a heart attack (in the acute phase), or may need time to ...
In response to ischemia, the brain degenerates by the process of liquefactive necrosis. There are various classification ... In the last decade, similar to myocardial infarction treatment, thrombolytic drugs were introduced in the therapy of cerebral ... Angioplasty and stenting have begun to be looked at as possible viable options in treatment of acute cerebral ischaemia. In a ... Results of the multi Mechanical Embolus Removal in Cerebral Ischemia (MERCI) trial, part I". AJNR Am J Neuroradiol. 27 (6): ...
Effects of spinal cord stimulation on myocardial ischaemia during daily life in patients with severe coronary artery disease. A ...
... Review clinical trials at Sutter Health. ... International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA). To determine whether a ... strategy of early cardiac catheterization reduces incidence of the composite of cardiovascular death or nonfatal myocardial ...
Air pollution is the second leading cause of deaths from noncommunicable diseases (‎NCDs)‎, after tobacco-smoking. In 2018, the third United Nations high-level meeting on NCDs recognized household and outdoor air pollution ...
Myocardial Ischemia Market Analysis by Type, End-Use and Region , Myocardial Ischemia Industry , Market Research Future (MRFR) ... Myocardial Ischemia Market Size to register a CAGR of 5.70% By 2030. ... Myocardial Ischemia Market Myocardial Ischemia Market Research Report Information by Type (Symptomatic and Asymptomatic), ... FIGURE 12 AMERICAS MYOCARDIAL ISCHEMIA MARKET SHARE BY REGION 2020 (%) 43 FIGURE 13 EUROPE MYOCARDIAL ISCHEMIA MARKET SHARE BY ...
... the extent of myocardial ischemia did not predict outcome benefit with revascularization in the ISCHEMIA trial (11). ... Stable MVCAD, noninvasive ischemia 2,287 4.6 years All-cause death or myocardial infarction 1.05 (0.87-1.27) ... Stable MVCAD, noninvasive ischemia 2,287 4.6 years All-cause death or myocardial infarction 1.05 (0.87-1.27) ... Stable MVCAD, moderate-severe ischemia (SDS ≥10%) 5,179 3.3 years All-cause death or myocardial infarction 0.90 (0.77-1.06) ...
... understanding myocardial ischemia ECG findings is essential for improved patient results. ... Non-ST elevation myocardial ischemia - manifested by ST depressions or T wave inversions without Q waves, with supporting ... ST elevation myocardial ischemia - manifested by ST elevations or hyperacute T waves, followed by T wave inversions often ... PATHOPHYSIOLOGY OF THE CURRENT OF INJURY AND MYOCARDIAL ISCHEMIA. In the normal patient, the ST segment is isoelectric with a ...
Calpain: the regulatory point of myocardial ischemia-reperfusion injury. Calpain: the regulatory point of myocardial ischemia- ... in myocardial ischemia-reperfusion. In addition, we also discussed the abnormal activation of calpain during myocardial ... Abnormally elevation of Ca2+ promotes the abnormal activation of calpain during myocardial ischemia-reperfusion, resulting in ... ischemia-reperfusion, the effect of calpain on myocardial repair, and the possible future research directions of calpain. ...
Molecular markers of ischemia in myocardial cardioprotection assessment in physical rehabilitation programs in cardiac patients ...
Posts about Global Myocardial Ischemia Market Forecast written by Ken Research ... Myocardial Ischemia MarketEurope Myocardial Ischemia MarketFrance Myocardial Ischemia MarketGermany Myocardial Ischemia Market ... Pacific Myocardial Ischemia MarketAstraZeneca Myocardial Ischemia MarketAustralia Myocardial Ischemia MarketBayer AG Myocardial ... Myocardial Ischemia Market ScopeGlobal Myocardial Ischemia Market ShareGlobal Myocardial Ischemia Market SizeGlobal Myocardial ...
Myocardial ischemia , Myocardial infarctionNLM classification: WG 300 Tags from this library: No tags from this library for ... Silent myocardial ischemia and infarction / Peter F. Cohn. By: Cohn, Peter FMaterial type: TextSeries: Basic and clinical ...
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Real-time detection and alerting for acute ST-segment elevation myocardial ischemia using an implantable, high-fidelity, ... Real-time detection and alerting for acute ST-segment elevation myocardial ischemia using an implantable, high-fidelity, ... CONCLUSIONS: This study demonstrates the ability of an implantable ischemia detection system to detect ST-segment elevation ... intracardiac electrogram monitoring from a permanently implantable ischemia detection system (IIDS), with long-range telemetry ...
... RUNGATSCHER, Alessio ... myocardial ischemia reperfusion; cardioprotection; NO donor; S-NO-HSA; Pressure Volume catheter; hemodynamics ... We investigated the cardioprotective effect of S-NO-HSA in a regional myocardial ischemia/reperfusion rat model reproducing ... These results suggest that S- NO-HSA might be an interesting option for patients undergoing regional myocardial ischemia ...
Safranal ameliorates myocardial ischemia.Jun 30, 2020. Click here to read the entire abstract. ... Safranal protects against ischemia-induced PC12 cell injury through inhibiting oxidative stress and apoptosis.Dec 31, 2020. ... Effect and mechanism of safranal on ISO-induced myocardial injury based on network pharmacology.Apr 05, 2023. ...
Ischemic preconditioning and myocardial tolerance to ischemia in experimental insulin-dependent diabetes mellitus.. April 3, ...
Myocardial Ischemia. The hypertrophied left ventricle and the prolonged ejection time (the time for the heart to eject blood) ... Myocardial scarring or fibrosis may develop with prolonged aortic stenosis, probably due to chronic subendocardial ischemia or ... Hypertrophied myocardial cells undergo apoptosis at a rate larger to that of regeneration.[4] In fact, angiotensin II promotes ... Fibrosis is an integral component of the myocardial hypertrophy.[4]. Early Diastolic Dysfunction. During the initial period of ...
Case reports Mechanisms of myocardial ischemia in a patient with left main coronary artery atresia. ... Case reports Mechanisms of myocardial ischemia in a patient with left main coronary artery atresia ...
Silent myocardial ischemia I25.700 Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina ... Acute coronary thrombosis not resulting in myocardial infarction I25.10 Atherosclerotic heart disease of native coronary artery ...
In this study we hypothesis that rivaroxaban pretreatment might play a role in reducing the complications of myocardial ... Home » RIVAROXABAN IMPROVES MYOCARDIAL ISCHEMIA REPERFUSION INJURY COMPLICATIONS IN OBESE RATS RIVAROXABAN IMPROVES MYOCARDIAL ... RIVAROXABAN IMPROVES MYOCARDIAL ISCHEMIA REPERFUSION INJURY COMPLICATIONS IN OBESE RATS. Hoda E. Mohamed *1, Sousou I. Ali1, ... INTRODUCTION: Myocardial ischemia is an imbalance between the oxygen supply and the oxygen demand in the myocardium.1 Although ...
... including myocardial infarction, myocardial ischemia, and unstable / stable angina); Venous thromboembolism (including deep ... myocardial ischemia; mitral valve insufficiency; multi-organ failure; non-structural dysfunction (i.e., entrapment by pannus, ... acute myocardial infarction; allergic reaction to antiplatelet agents, contrast medium, or valve components; aortic rupture; ...
Reduces Myocardial Infarct Size in a Rat Ischemia/Reperfusion Model ... Reduces Myocardial Infarct Size in a Rat Ischemia/Reperfusion Model Wangde Dai, Sharon L Hale, Rohith Nayak, Robert A Kloner*. ... However, in our present study using the rat ischemia/reperfusion model, A2AAR agonist ATL 313 did not reduce myocardial infarct ... We investigated whether ATL 313, a new selective A2AAR agonist, could reduce myocardial infarct size in a rat ischemia/ ...
2021 Myocardial Fibrosis (Cardiovascular) - Drugs in Development, 2021 Summary Global Markets Directs latest Pharmaceutical ... Myocardial Ischemia (Cardiovascular) - Drugs In Development, 2021. June, 2021 , Published by: Global Markets Direct , USD $ ... Myocardial Fibrosis - Pipeline by MandalMed Inc, 2021. Myocardial Fibrosis - Pipeline by NovoMedix LLC, 2021. Myocardial ... Myocardial Fibrosis - Pipeline by Vectus Biosystems Ltd, 2021. Myocardial Fibrosis - Dormant Projects, 2021. Myocardial ...
Events reported have included coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular ... Risk of Myocardial Ischemia and/or Infarction and Other Adverse Cardiac Events:. Dihydroergotamine Mesylate Nasal Spray should ... Myocardial and peripheral vascular ischemia have been reported with Dihydroergotamine Mesylate Nasal Spray. ... history of myocardial infarction, or documented silent ischemia) or to patients who have clinical symptoms or findings ...
Myocardial Ischemia. en. dc.subject.mesh. Coronary Disease. en. dc.subject.mesh. Myocardial Infarction. en. ...
Effect of Simulated Geomagnetic Activity on Myocardial Ischemia/Reperfusion Injury in Rats. Hui WuI; Weiyu ChangI; Yanglin Deng ... Effect of Simulated Geomagnetic Activity on Myocardial Ischemia/Reperfusion Injury in Rats. Braz J Cardiovasc Surg. 2019;34(6): ...
Myocardial ischemia. *Myocardial ischemia reported in patients treated with ondansetron; in some cases, predominantly during ... myocardial ischemia, transient ECG changes including QT/QTc interval prolongation have been reported ... monitor or advise patients for signs or symptoms of myocardial ischemia after oral administration of ondansetron ...
Renal Denervation Attenuates Adverse Remodeling and Intramyocardial Inflammation in Acute Myocardial Infarction With Ischemia- ... Renal Denervation Attenuates Adverse Remodeling and Intramyocardial Inflammation in Acute Myocardial Infarction With Ischemia- ...
Features associated with myocardial ischemia in anomalous aortic origin of a coronary artery: A Congenital Heart Surgeons ... Dive into the research topics of Features associated with myocardial ischemia in anomalous aortic origin of a coronary artery ...
... ischemia. We used 31P NMR spectroscopy to determine changes in myocardial energetics and intracellular and extracellular ... In the glucose-hearts, Rb+ influx rate was threefold higher, intracellular Na+ was fivefold lower at the end of ischemia and ... In hearts provided with 11 mM glucose throughout ischemia, glycolysis continued and ATP was twofold higher than in hearts ... We propose that continuation of glycolysis throughout low flow ischemia allowed maintenance of sufficient Na+/K+ ATPase ...
  • To determine whether a strategy of early cardiac catheterization reduces incidence of the composite of cardiovascular death or nonfatal myocardial infarction. (sutterhealth.org)
  • A nuclear substudy in 314 patients showed a significantly greater ischemia reduction following revascularization in those with moderate to severe ischemia, but this did not translate into significant reduction in death or myocardial infarction ( 16 ). (diabetesjournals.org)
  • Step 6: QRS complex - If Q waves are prominent, consider myocardial infarction. (acls.com)
  • These abnormalities denote myocardial ischemia or infarction. (acls.com)
  • CONCLUSIONS: This study demonstrates the ability of an implantable ischemia detection system to detect ST-segment elevation from coronary occlusion in a porcine model of ST-segment elevation myocardial infarction. (duke.edu)
  • Such a system, with real-time alerting capability, could advance the time frame of reperfusion therapy and potentially prevent, rather than interrupt, acute myocardial infarction in patients with coronary artery disease. (duke.edu)
  • Silent myocardial ischemia and infarction / Peter F. Cohn. (who.int)
  • Myocardial infarction, A 2A adenosine receptor, ATL 313. (opencardiovascularmedicinejournal.com)
  • This article is intended for primary care clinicians, cardiologists, emergency medicine specialists, and other specialists who care for patients at risk for myocardial infarction. (medscape.com)
  • List clinical definitions of myocardial infarction. (medscape.com)
  • Patients with myocardial infarction in the chest, heartburn, lump in oesophageal origin. (who.int)
  • This study in May 2002, part of the Jordan Department of Statistics national cross-sectional, multistage employment and unemployment survey, measured the prevalence of self-reported myocardial infarction (MI) and the association with modifiable risk factors among Jordanians aged 40+ years. (who.int)
  • metabolic acidosis, arrhythmias, myocardial ischemia or infarction, and noncardiogenic pulmonary edema, although any organ system might be involved. (cdc.gov)
  • Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION). (bvsalud.org)
  • Effects of spinal cord stimulation on myocardial ischaemia during daily life in patients with severe coronary artery disease. (bmj.com)
  • Whether an invasive strategy with revascularization reduced outcomes among patients with stable coronary artery disease (CAD) with inducible ischemia using SPECT-MPI was first explored in the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial, and the results showed no clinical benefit compared with GDMT among 2,287 patients with significant obstructive CAD. (diabetesjournals.org)
  • The death certificate, completed by the county chief deputy coroner, and the autopsy report, completed by the pathologist, listed "cardiac dysrhythmia due to atherosclerotic coronary artery disease and myocardial bridging of anterior descending coronary artery" as the cause of death. (cdc.gov)
  • An autopsy, conducted by a private company, listed "cardiac arrhythmia" due to "myocardial ischemia" due to "coronary artery disease" as the cause of death. (cdc.gov)
  • Myocardial ischemia and weaning failure in patients with coronary artery disease: an update. (bvsalud.org)
  • Calpain: the regulatory point of myocardial ischemia-reperfusion injury. (bvsalud.org)
  • In this study we hypothesis that rivaroxaban pretreatment might play a role in reducing the complications of myocardial ischemic reperfusion injury (IRI) in a rat model of obesity. (ijpsr.com)
  • a mediator of myocardial ischemia reperfusion injury. (ijpsr.com)
  • The cardioprotective effects of activation of the A 2A adenosine receptor (A 2A AR) on ischemia/reperfusion injury in the heart remain controversial. (opencardiovascularmedicinejournal.com)
  • Ischemic preconditioning and myocardial tolerance to ischemia in experimental insulin-dependent diabetes mellitus. (kopfinstruments.com)
  • The amplitude of acute ischemic ST elevation indicates the severity of the ischemia. (acls.com)
  • Real-time detection and alerting for acute ST-segment elevation myocardial ischemia using an implantable, high-fidelity, intracardiac electrogram monitoring system with long-range telemetry in an ambulatory porcine model. (duke.edu)
  • OBJECTIVES: The purpose of this study was to evaluate feasibility of using real-time, high-fidelity, intracardiac electrogram monitoring from a permanently implantable ischemia detection system (IIDS), with long-range telemetry capability to detect ST-segment shifts associated with acute or subacute coronary occlusion in a porcine model. (duke.edu)
  • Define electrocardiogram changes suggestive of acute myocardial ischemia. (medscape.com)
  • If marked ST elevation or depression in multiple leads is observed, consider severe ischemia or ischemia affecting large regions of the myocardium. (acls.com)
  • Buy Now Myocardial ischemia occurs when blood flow to heart muscle or myocardium is obstructed by a complete or partial blockage of a coronary artery by a buildup of plaques (atherosclerosis). (wordpress.com)
  • Myocardial ischemia is an imbalance between the oxygen supply and the oxygen demand in the myocardium. (ijpsr.com)
  • The obese rats subjected to IRI showed significant increases in the inflammatory markers (myocardial angiotensin II, tumor necrosis factor alpha (TNF- α), interleukin 8 (IL-8) contents and monocyte chemoattractant protein 1 (MCP-1) gene expression) compared with control rats subjected to IRI. (ijpsr.com)
  • The International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial was designed to overcome a key limitation of previous trials by ensuring enrollment of high-risk patients. (diabetesjournals.org)
  • 7 ) retrospectively explore the long-term association of survival benefit from early revascularization with the magnitude of ischemia in patients with or without diabetes in 41,982 patients who underwent SPECT-MPI from 1998 to 2017 at a single center. (diabetesjournals.org)
  • These results suggest that S- NO-HSA might be an interesting option for patients undergoing regional myocardial ischemia reperfusion. (univr.it)
  • Dr. Amish Raval and his team at the University of Wisconsin Hospital and Clinics in Madison, Wisconsin recently announced that it is one of the first medical centers in the United States participating in an important study investigating adult stem cells to treat patients with chronic myocardial ischemia. (scitizen.com)
  • One is the epicardial stenosis-centric model that drives noninvasive stress tests to detect ischemia, which, in turn, justifies coronary angiography followed by revascularization, if feasible. (diabetesjournals.org)
  • As in the COURAGE trial ( 17 ), the extent of myocardial ischemia did not predict outcome benefit with revascularization in the ISCHEMIA trial ( 11 ). (diabetesjournals.org)
  • Abnormally elevation of Ca2+ promotes the abnormal activation of calpain during myocardial ischemia - reperfusion , resulting in myocardial injury and cardiac dysfunction. (bvsalud.org)
  • Likewise, in transmural ischemia, a shortened action potential occurs which causes an abnormal current flow during the systolic stage of the cardiac cycle. (acls.com)
  • In addition, we also discussed the abnormal activation of calpain during myocardial ischemia - reperfusion , the effect of calpain on myocardial repair, and the possible future research directions of calpain . (bvsalud.org)
  • Myocardial fibrosis is an abnormal thickening of the heart valves due to inappropriate proliferation of cardiac fibroblasts. (marketresearch.com)
  • We investigated the cardioprotective effect of S-NO-HSA in a regional myocardial ischemia/reperfusion rat model reproducing clinical scenarios. (univr.it)
  • In this paper , we mainly reviewed the effects of calpain in various programmed cell death (such as apoptosis , mitochondrial-mediated necrosis , autophagy-dependent cell death , and parthanatos ) in myocardial ischemia - reperfusion . (bvsalud.org)
  • Effect and mechanism of safranal on ISO-induced myocardial injury based on network pharmacology. (greenmedinfo.com)
  • Myocardial Injury due to IRI results in cardiac contractile dysfunction, arrhythmias, and irreversible myocytes damage. (ijpsr.com)
  • The role of Na+/K+ ATPase activity during low flow ischemia in preventing myocardial injury: a 31P, 23Na and 87Rb NMR spectroscopic study. (ox.ac.uk)
  • An increase in intracellular Na+ during ischaemia has been associated with myocardial injury. (ox.ac.uk)
  • We propose that continuation of glycolysis throughout low flow ischemia allowed maintenance of sufficient Na+/K+ ATPase activity to prevent the increase in intracellular Na+ that would otherwise have led to myocardial injury. (ox.ac.uk)
  • Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Myocardial Fibrosis - Drugs In Development, 2021, provides an overview of the Myocardial Fibrosis (Cardiovascular) pipeline landscape. (marketresearch.com)
  • Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Myocardial Fibrosis - Drugs In Development, 2021, provides comprehensive information on the therapeutics under development for Myocardial Fibrosis (Cardiovascular), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (marketresearch.com)
  • The Myocardial Fibrosis (Cardiovascular) pipeline guide also reviews of key players involved in therapeutic development for Myocardial Fibrosis and features dormant and discontinued projects. (marketresearch.com)
  • Myocardial Fibrosis (Cardiovascular) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. (marketresearch.com)
  • The pipeline guide provides a snapshot of the global therapeutic landscape of Myocardial Fibrosis (Cardiovascular). (marketresearch.com)
  • The pipeline guide reviews pipeline therapeutics for Myocardial Fibrosis (Cardiovascular) by companies and universities/research institutes based on information derived from company and industry-specific sources. (marketresearch.com)
  • The pipeline guide reviews key companies involved in Myocardial Fibrosis (Cardiovascular) therapeutics and enlists all their major and minor projects. (marketresearch.com)
  • The pipeline guide evaluates Myocardial Fibrosis (Cardiovascular) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. (marketresearch.com)
  • Find and recognize significant and varied types of therapeutics under development for Myocardial Fibrosis (Cardiovascular). (marketresearch.com)
  • Formulate corrective measures for pipeline projects by understanding Myocardial Fibrosis (Cardiovascular) pipeline depth and focus of Indication therapeutics. (marketresearch.com)
  • CONCLUSIONS: S-NO-HSA limits the infarct size, improves diastolic and systolic function and the energetic reserve of the heart after regional myocardial ischemia/reperfusion. (univr.it)
  • Because CYP 3A4 inhibition elevates the serum levels of DIHYDROERGOTAMINE, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. (nih.gov)
  • In this study, we determined whether inhibition of Na+/K+ ATPase activity contributes to this increase and whether Na+/K+ ATPase activity can be maintained by provision of glucose to perfused rat hearts during low flow, 0.5 ml/min, ischemia. (ox.ac.uk)
  • Also as a burn-like sublingual nitroglycerin may also performed to assess the patient's sensation, fullness in the chest, suggest ischaemia. (who.int)
  • Standard model of a myocardial cell action potential. (acls.com)
  • Therefore, the present study was designed to show the effect of Rivaroxaban pretreatment, a new factor Xa inhibitor in a rat model of obesity and myocardial IRI. (ijpsr.com)
  • We investigated whether ATL 313, a new selective A 2A AR agonist, could reduce myocardial infarct size in a rat ischemia/reperfusion model. (opencardiovascularmedicinejournal.com)
  • 0.05), the maximum effect is produced when the drug is administered before ischemia. (univr.it)
  • 10% ischemia decreases short-term cardiac death and long-term all-cause mortality ( 2 - 7 ) ( Table 1 ). (diabetesjournals.org)
  • At this point, all of the myocardial cells are in the plateau phase of the action potential (Figure 1). (acls.com)
  • If emergency intervention is not described as a pressure, cessation of activity is suggestive of required, a focused history and squeezing, tightness, or crushing ischaemia. (who.int)
  • Cardioprotective role of S-Nitroso Human Serum Albuminduring regional myocardial ischemia-reperfusion. (univr.it)
  • BACKGROUND: The early period of reperfusion after myocardial ischemia is critical for endothelial dysfunction and the impairment of nitric oxide synthesis plays a critical role. (univr.it)
  • The ?Autologous Cellular Therapy CD34+ Chronic Myocardial Ischemia (ACT34-CMI) Trial? (scitizen.com)
  • Myocardial ischemia was induced by left anterior descending artery ligation (LAD). (ijpsr.com)
  • In the glucose-hearts, Rb+ influx rate was threefold higher, intracellular Na+ was fivefold lower at the end of ischemia and functional recovery during reperfusion was twofold higher. (ox.ac.uk)
  • R- hirudin (a commercially available anticoagulant drug used previously in attenuating the harmful effects of myocardial IRI) was used as a positive control in this study. (ijpsr.com)
  • The infusion started 15 minutes before the beginning of ischemia in a group (Pre-I) whereas it starter 15 min after the initiation of ischemia in the other group (Post-I). The infusion continued until the first 30 minutes of reperfusion in both groups. (univr.it)
  • Tau-Weiss (index of ventricular relaxation), LV end-diastolic pressure (LVEDP) and end-diastolic P-V relationship (EDPVR) (indexes of ventricular stiffness) were significantly decreased with S-NO-HSA both in Pre-I and Post-I group after ischemia and during the 24 h reperfusion. (univr.it)