NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most commonly by a THROMBUS or EMBOLUS.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Elements of limited time intervals, contributing to particular results or situations.
MYOCARDIAL INFARCTION in which the anterior wall of the heart is involved. Anterior wall myocardial infarction is often caused by occlusion of the left anterior descending coronary artery. It can be categorized as anteroseptal or anterolateral wall myocardial infarction.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Streptococcal fibrinolysin . An enzyme produced by hemolytic streptococci. It hydrolyzes amide linkages and serves as an activator of plasminogen. It is used in thrombolytic therapy and is used also in mixtures with streptodornase (STREPTODORNASE AND STREPTOKINASE). EC 3.4.-.
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The hospital unit in which patients with acute cardiac disorders receive intensive care.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
The return of a sign, symptom, or disease after a remission.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The veins and arteries of the HEART.
Shock resulting from diminution of cardiac output in heart disease.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
MYOCARDIAL INFARCTION in which the inferior wall of the heart is involved. It is often caused by occlusion of the right coronary artery.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
The circulation of blood through the CORONARY VESSELS of the HEART.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Disease having a short and relatively severe course.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Pressure, burning, or numbness in the chest.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
The hollow, muscular organ that maintains the circulation of the blood.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
Laceration or tearing of cardiac tissues appearing after MYOCARDIAL INFARCTION.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
The confinement of a patient in a hospital.
Analyses for a specific enzyme activity, or of the level of a specific enzyme that is used to assess health and disease risk, for early detection of disease or disease prediction, diagnosis, and change in disease status.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
Bleeding or escape of blood from a vessel.
One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
Formation and development of a thrombus or blood clot in the blood vessel.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
Narrowing or constriction of a coronary artery.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Services specifically designed, staffed, and equipped for the emergency care of patients.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Agents that prevent clotting.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
Contractile activity of the MYOCARDIUM.
An isoenzyme of creatine kinase found in the CARDIAC MUSCLE.
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Disease-related laceration or tearing of tissues of the heart, including the free-wall MYOCARDIUM; HEART SEPTUM; PAPILLARY MUSCLES; CHORDAE TENDINEAE; and any of the HEART VALVES. Pathological rupture usually results from myocardial infarction (HEART RUPTURE, POST-INFARCTION).
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Examinations used to diagnose and treat heart conditions.
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
Surgical removal of an obstructing clot or foreign material from a blood vessel at the point of its formation. Removal of a clot arising from a distant site is called EMBOLECTOMY.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Abnormal fluid retention by the body due to impaired cardiac function or heart failure. It is usually characterized by increase in venous and capillary pressure, and swollen legs when standing. It is different from the generalized edema caused by renal dysfunction (NEPHROTIC SYNDROME).
The span of viability of a tissue or an organ.
Therapy with two or more separate preparations given for a combined effect.
Infarctions that occur in the BRAIN STEM which is comprised of the MIDBRAIN; PONS; and MEDULLA OBLONGATA. There are several named syndromes characterized by their distinctive clinical manifestations and specific sites of ischemic injury.
Laceration or tearing of the VENTRICULAR SEPTUM, usually caused by MYOCARDIAL INFARCTION.
The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.
A localized bulging or dilatation in the muscle wall of a heart (MYOCARDIUM), usually in the LEFT VENTRICLE. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are HEMATOMA caused by myocardial rupture.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
An acylated inactive complex of streptokinase and human lysine-plasminogen. After injection, the acyl group is slowly hydrolyzed, producing an activator that converts plasminogen to plasmin, thereby initiating fibrinolysis. Its half-life is about 90 minutes compared to 5 minutes for TPA; (TISSUE PLASMINOGEN ACTIVATOR); 16 minutes for UROKINASE-TYPE PLASMINOGEN ACTIVATOR and 23 minutes for STREPTOKINASE. If treatment is initiated within 3 hours of onset of symptoms for acute myocardial infarction, the drug preserves myocardial tissue and left ventricular function and increases coronary artery patency. Bleeding complications are similar to other thrombolytic agents.
One of the minor protein components of skeletal muscle. Its function is to serve as the calcium-binding component in the troponin-tropomyosin B-actin-myosin complex by conferring calcium sensitivity to the cross-linked actin and myosin filaments.
Markedly reduced or absent REPERFUSION in an infarct zone following the removal of an obstruction or constriction of an artery.
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
Substances used to allow enhanced visualization of tissues.
Counterpulsation in which a pumping unit synchronized with the patient's electrocardiogram rapidly fills a balloon in the aorta with helium or carbon dioxide in early diastole and evacuates the balloon at the onset of systole. As the balloon inflates, it raises aortic diastolic pressure, and as it deflates, it lowers aortic systolic pressure. The result is a decrease in left ventricular work and increased myocardial and peripheral perfusion.
Interfacility or intrahospital transfer of patients. Intrahospital transfer is usually to obtain a specific kind of care and interfacility transfer is usually for economic reasons as well as for the type of care provided.
Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cardiac patient.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Conveying ill or injured individuals from one place to another.
The interval of time between onset of symptoms and receiving therapy.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Low-molecular-weight fragment of heparin, having a 4-enopyranosuronate sodium structure at the non-reducing end of the chain. It is prepared by depolymerization of the benzylic ester of porcine mucosal heparin. Therapeutically, it is used as an antithrombotic agent. (From Merck Index, 11th ed)
The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.
Spasm of the large- or medium-sized coronary arteries.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
The process of accepting patients. The concept includes patients accepted for medical and nursing care in a hospital or other health care institution.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
Blocking of a blood vessel by an embolus which can be a blood clot or other undissolved material in the blood stream.
A range of values for a variable of interest, e.g., a rate, constructed so that this range has a specified probability of including the true value of the variable.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Inhaling and exhaling the smoke of burning TOBACCO.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
The removal of secretions, gas or fluid from hollow or tubular organs or cavities by means of a tube and a device that acts on negative pressure.
Situations or conditions requiring immediate intervention to avoid serious adverse results.
The study of the heart, its physiology, and its functions.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.
Application of a ligature to tie a vessel or strangulate a part.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
The period of confinement of a patient to a hospital or other health facility.
The degree to which BLOOD VESSELS are not blocked or obstructed.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
The administrative process of discharging the patient, alive or dead, from hospitals or other health facilities.
Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Conditional probability of exposure to a treatment given observed covariates.
Motion pictures of the passage of contrast medium through blood vessels.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)
Recording of the moment-to-moment electromotive forces of the heart on a plane of the body surface delineated as a vector function of time.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
A vehicle equipped for transporting patients in need of emergency care.
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
A conjugated protein which is the oxygen-transporting pigment of muscle. It is made up of one globin polypeptide chain and one heme group.
The prevention of recurrences or exacerbations of a disease or complications of its therapy.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
Use of HIRUDINS as an anticoagulant in the treatment of cardiological and hematological disorders.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.

Site of myocardial infarction. A determinant of the cardiovascular changes induced in the cat by coronary occlusion. (1/19124)

The influence of site of acute myocardial infarction on heart rate, blood pressure, cardiac output, total peripheral resistance (TPR), cardiac rhythm, and mortality was determined in 58 anesthetized cats by occlusion of either the left anterior descending (LAD), left circumflex or right coronary artery. LAD occlusion resulted in immediate decrease in cardiac output, heart rate, and blood pressure, an increase in TPR, and cardiac rhythm changes including premature ventricular beats, ventricular tachycardia, and occasionally ventricular fibrillation. The decrease in cardiac output and increase in TPR persisted in the cats surviving a ventricular arrhythmia. In contrast, right coronary occlusion resulted in a considerably smaller decrease in cardiac output. TPR did not increase, atrioventricular condition disturbances were common, and sinus bradycardia and hypotension persisted in the cats recovering from an arrhythmia. Left circumflex ligation resulted in cardiovascular changes intermediate between those produced by occlusion of the LAD or the right coronary artery. Mortality was similar in each of the three groups. We studied the coronary artery anatomy in 12 cats. In 10, the blood supply to the sinus node was from the right coronary artery and in 2, from the left circumflex coronary artery. The atrioventricular node artery arose from the right in 9 cats, and from the left circumflex in 3. The right coronary artery was dominant in 9 cats and the left in 3. In conclusion, the site of experimental coronary occlusion in cats is a major determinant of the hemodynamic and cardiac rhythm changes occurring after acute myocardial infarction. The cardiovascular responses evoked by ligation are related in part to the anatomical distribution of the occluded artery.  (+info)

Hierarchy of ventricular pacemakers. (2/19124)

To characterize the pattern of pacemaker dominance in the ventricular specialized conduction system (VSCS), escape ventricular pacemakers were localized and quantified in vivo and in virto, in normal hearts and in hearts 24 hours after myocardial infarction. Excape pacemaker foci were localized in vivo during vagally induced atrial arrest by means of electrograms recorded from the His bundle and proximal bundle branches and standard electrocardiographic limb leads. The VSCS was isolated using a modified Elizari preparation or preparations of each bundle branch. Peacemakers were located by extra- and intracellular recordings. Escape pacemaker foci in vivo were always in the proximal conduction system, usually the left bundle branch. The rate was 43+/-11 (mean+/-SD) beats/min. After beta-adrenergic blockade, the mean rate fell to 31+/-10 beats/min, but there were no shifts in pacemaker location. In the infarcted hearts, pacemakers were located in the peripheral left bundle branch. The mean rate was 146+/-20 beats/min. In isolated normal preparations, the dominant pacemakers usually were in the His bundle, firing at a mean rate of 43+/-10 beats/min. The rates of pacemakers diminished with distal progression. In infarcted hearts, the pacemakers invariably were in the infarct zone. The mean firing rates were not influenced by beta-adrenergic blockade. The results indicate that the dominant pacemakers are normally in the very proximal VSCS, but after myocardial infarction pacemaker dominance is shifted into the infarct. Distribution of pacemaker dominance is independent of sympathetic influence.  (+info)

Anti-heart autoantibodies in ischaemic heart disease patients. (3/19124)

One hundred and ninety-nine ischaemic heart disease (IHD) patients were studied with regard to the prevalence of anti-heart autoantibodies (AHA). The incidence of AHA in IHD patients was 1%: one out of 102 patients who suffered acute myocardial infarction (AMI), one out of seventy-two patients who suffered from acute coronary insufficiency (ACI), and none out of twenty-five patients with other signs and symptoms of IHD, had AHA in their sera. An additional 2% of patients who suffered from AMI developed detectable antibody levels during a follow-up period of 15 days. In comparison,, 53% of patients (eight out of fifteen) who underwent heart surgery and who had no AHA prior to operation, developed these antibodies in their sera during 1-2 weeks following operation.  (+info)

Is hospital care involved in inequalities in coronary heart disease mortality? Results from the French WHO-MONICA Project in men aged 30-64. (4/19124)

OBJECTIVES: The goal of the study was to assess whether possible disparities in coronary heart disease (CHD) management between occupational categories (OC) in men might be observed and contribute to the increasing inequalities in CHD morbidity and mortality reported in France. METHODS: The data from the three registers of the French MONICA Collaborative Centres (MCC-Lille, MCC-Strasbourg, and MCC-Toulouse) were analysed during two period: 1985-87 and 1989-91. Acute myocardial infarctions and coronary deaths concerning men, aged 30-64 years, were included. Non-professionally active and retired men were excluded. Results were adjusted for age and MCC, using a logistic regression analysis. RESULTS: 605 and 695 events were analysed for 1985-87 and 1989-91, respectively. Out of hospital cardiac arrests, with or without cardiac resuscitation, and 28 day case fatality rates were lower among upper executives in both periods. A coronarography before the acute event had been performed more frequently in men of this category and the proportion of events that could be hospitalised was higher among them. In both periods, the management of acute myocardial infarctions in hospital and prescriptions on discharge were similar among occupational categories. CONCLUSIONS: For patients who could be admitted to hospital, the management was found to be similar among OCs, as was the 28 day case fatality rate among the hospitalised patients. In contrast, lower prognosis and higher probability of being hospitalised after the event among some categories suggest that pre-hospital care and the patient's conditions before the event are the primary factors involved.  (+info)

Optimal thrombolytic strategies for acute myocardial infarction--bolus administration. (5/19124)

Optimal strategies for thrombolysis in myocardial infarction (TIMI) are still being sought because the TIMI 3 flow rates achievable using standard regimens average approximately 60%. Double bolus administration of recombinant tissue plasminogen activator (tPA) is a novel approach with potential for earlier patency combined with ease of administration. We reviewed total patency rates, TIMI 3 patency rates, mortality, stroke and intracranial haemorrhage rates in the major trials of accelerated infusion tPA/bolus tPA/reteplase in acute myocardial infarction. A direct comparison was performed with results of two recent trials of double bolus (two 50 mg boli, 30 min apart) vs. accelerated infusion tPA: the Double Bolus Lytic Efficacy Trial (DBLE), an angiographic study, and the COBALT Trial, a mortality study. The DBLE trial showed equivalent patency rates for accelerated infusion and double bolus administration of tPA. Reviewing other angiographic trials, total patency and TIMI 3 patency rates achievable with double bolus tPA were comparable to those with accelerated infusion tPA or bolus reteplase administration. The COBALT study demonstrated a 30-day mortality of 7.53% in patients treated with accelerated infusion tPA compared with 7.98% for double bolus tPA treated patients. The small excess in mortality with double bolus treatment was confined to the elderly; in those < or = 75 years, mortality rates were 5.6% and 5.7%, for double bolus and accelerated infusion, respectively, and rates for death or non-fatal stroke were 6.35% and 6.3%, respectively. Comparison with other trials demonstrated mortality, stroke and intracranial haemorrhage rates with double bolus treatment similar to those associated with either accelerated infusion tPA or bolus reteplase treatment. Double bolus administration of tPA to patients with acute myocardial infarction is associated with total patency, TIMI 3 patency, mortality, stroke and intracranial haemorrhage rates similar to those associated with either accelerated infusion of tPA or bolus reteplase.  (+info)

Premature morbidity from cardiovascular and cerebrovascular diseases in women with systemic lupus erythematosus. (6/19124)

OBJECTIVE: To determine rates of morbidity due to cardiovascular and cerebrovascular diseases among women with systemic lupus erythematosus (SLE). METHODS: I used the California Hospital Discharge Database, which contains information on all discharges from acute care hospitals in California, to identify women with SLE who had been hospitalized for treatment of either acute myocardial infarction (AMI), congestive heart failure (CHF), or cerebrovascular accident (CVA) from 1991 to 1994. I compared the proportions of hospitalizations for each cause among women with SLE with those in a group of women without SLE, for 3 age strata (18-44 years, 45-64 years, and > or =65 years). RESULTS: Compared with young women without SLE, young women with SLE were 2.27 times more likely to be hospitalized because of AMI (95% confidence interval [95% CI] 1.08-3.46), 3.80 times more likely to be hospitalized because of CHF (95% CI 2.41-5.19), and 2.05 times more likely to be hospitalized because of CVA (95% CI 1.17-2.93). Among middle-aged women with SLE, the frequencies of hospitalization for AMI and CVA did not differ from those of the comparison group, but the risk of hospitalization for CHF was higher (odds ratio [OR] 1.39, 95% CI 1.05-1.73). Among elderly women with SLE, the risk of hospitalization for AMI was significantly lower (OR 0.70, 95% CI 0.51-0.89), the risk of hospitalization for CHF was higher (OR 1.25, 95% CI 1.01-1.49), and the risk of hospitalization for CVA was not significantly different from those in the comparison group. CONCLUSION: Young women with SLE are at substantially increased risk of AMI, CHF, and CVA. The relative odds of these conditions decrease with age among women with SLE.  (+info)

Expression of skeletal muscle sarcoplasmic reticulum calcium-ATPase is reduced in rats with postinfarction heart failure. (7/19124)

OBJECTIVE: To determine whether heart failure in rats is associated with altered expression of the skeletal muscle sarcoplasmic reticulum Ca2+-ATPase (SERCA). METHODS: SERCA protein and mRNA were examined in the soleus muscles of eight female rats with heart failure induced by coronary artery ligation, six weeks after the procedure (mean (SEM) left ventricular end diastolic pressure 20.4 (2.2) mm Hg) and in six sham operated controls by western and northern analyses, respectively. RESULTS: SERCA-2a isoform protein was reduced by 16% (112 000 (4000) v 134 000 (2000) arbitrary units, p < 0.001), and SERCA-2a messenger RNA was reduced by 59% (0.24 (0. 06) v 0.58 (0.02) arbitrary units, p < 0.001). Although rats with heart failure had smaller muscles (0.54 mg/g v 0.66 mg/g body weight), no difference in locomotor activity was observed. CONCLUSIONS: These results may explain the previously documented abnormalities in calcium handling in skeletal muscle from animals with the same model of congestive heart failure, and could be responsible for the accelerated muscle fatigue characteristic of patients with heart failure.  (+info)

Recurring myocardial infarction in a 35 year old woman. (8/19124)

A 35 year old woman presented with acute myocardial infarction without any of the usual risk factors: she had never smoked; she had normal blood pressure; she did not have diabetes; plasma concentrations of total cholesterol and high and low density lipoprotein cholesterol, fibrinogen, homocysteine, and Lp(a) lipoprotein were normal. She was not taking oral contraceptives or any other medication. Coronary angiography showed occlusion of the left anterior descending coronary artery but no evidence of arteriosclerosis. Medical history disclosed a previous leg vein thrombosis with pulmonary embolism. Coagulation analysis revealed protein C deficiency. The recognition of protein C deficiency as a risk factor for myocardial infarction is important as anticoagulation prevents further thrombotic events, whereas inhibitors of platelet aggregation are ineffective.  (+info)

Indian Journal of Basic and Applied Medical Research; December 2013: Vol.-3, Issue-1 , 80-87 Original article : Effect of acute myocardial infarction on serum zinc level * DR. PRAVIN P. SHEKOKAR 1, DR. MRS. S. D. KAUNDINYA2 1Assistant Professor, Department of Physiology, Government Medical College, Akola, Collector Office Road, Akola. Pin 444001 (Maharashtra), India 2Professor & Head of Dept, Department of Physiology, Grant Government Medical College And Sir J.J. Hospital, Mumbai-8, India *Corrersponding author : Email: [email protected] Abstract: Introduction: Myocardial infarction is a common presentation of coronary artery disease. The diagnosis of acute myocardial infarction (AMI) is of vital importance from the management and prognosis point of view. Objective: The purpose of this study was to investigate serum zinc level in acute myocardial infarction patients and to correlate it with biochemical parameter SGOT. Methods: In the present study 30 patients suffering from acute myocardial ...
BACKGROUND: The Thrombolysis In Myocardial Infarction (TIMI) Risk Score has been shown to predict prognosis in acute coronary syndromes (ACS) comprised of unstable angina (UA) and non-ST segment elevation myocardial infarction (STEMI). We sought to evaluate the impact of newer antiplatelet and antithrombotic therapies for ACS, such as glycoprotein IIb/IIIa inhibitors (GPI) and low molecular weight heparin (LMWH), on in-hospital outcomes over time in patients (pts) with similar TIMI risk scores.. METHODS: The baseline demographics and clinical outcomes of pts with ACS (UA and non-STEMI) in 1998 (Group 1998) and 2000 (Group 2000) at a single large university medical center were compared using a prospectively collected database. In-hospital major adverse cardiac events (MACE) included death, MI, or recurrent angina that resulted in urgent revascularization. Risk was estimated by utilizing the TIMI Risk Score, which uses 7 predictor variables: age , 65 years, at least 3 risk factors for coronary ...
TY - JOUR. T1 - Non-ST-segment-elevation myocardial infarction among patients with chronic kidney disease. T2 - A propensity score-matched comparison of percutaneous coronary intervention versus conservative management. AU - Bhatia, Subir. AU - Arora, Shilpkumar. AU - Bhatia, Sravya M.. AU - Al-Hijji, Mohammed. AU - Reddy, Yogesh N.V.. AU - Patel, Parshva. AU - Rihal, Charanjit S.. AU - Gersh, Bernard J.. AU - Deshmukh, Abhishek. N1 - Publisher Copyright: © 2018 The Authors.. PY - 2018/3/20. Y1 - 2018/3/20. N2 - Background--Chronic kidney disease (CKD) remains an independent predictor of cardiovascular morbidity and mortality. CKD complicates referral for percutaneous coronary intervention (PCI) in non-ST-segment-elevation myocardial infarction (NSTEMI) patients because of the risk for acute kidney injury and the need for dialysis, with American College of Cardiology/American Heart Association guidelines underscoring the limited data on these patients. Methods and Results--Using the National ...
TY - JOUR. T1 - Subarachnoid hemorrhage simulating myocardial infarction. AU - De Marchena, Eduardo. AU - Pittaluga, Juan M.. AU - Ferreira, Alexandre C.. AU - Lowery, Maureen. AU - Romanelli, Renzo. AU - Morales, Azorides. PY - 1996/2/1. Y1 - 1996/2/1. N2 - We describe a patient with a subarachnoid hemorrhage that presented with electrocardiographic evidence of transmural myocardial infarction. The patient was found to have normal coronaries and on autopsy revealed generalized myocytolysis with no evidence of transmural myocardial infarction. This case illustrates the value of acute coronary angiography in patients with altered mental status and suspected myocardial infarction.. AB - We describe a patient with a subarachnoid hemorrhage that presented with electrocardiographic evidence of transmural myocardial infarction. The patient was found to have normal coronaries and on autopsy revealed generalized myocytolysis with no evidence of transmural myocardial infarction. This case illustrates the ...
TY - JOUR. T1 - Diabetes Mellitus and Cardiogenic Shock Complicating Acute Myocardial Infarction. AU - Echouffo Tcheugui, Justin. AU - Kolte, Dhaval. AU - Khera, Sahil. AU - Aronow, Herbert D.. AU - Abbott, J. Dawn. AU - Bhatt, Deepak L.. AU - Fonarow, Gregg C.. PY - 2018/7/1. Y1 - 2018/7/1. N2 - Background: Diabetes mellitus (diabetes) increases the risk of acute myocardial infarction, which can result in cardiogenic shock. Data on the relation of diabetes and the occurrence and prognosis of cardiogenic shock postacute myocardial infarction are scant. Methods: Among the National Inpatient Sample patients aged ≥18 years and hospitalized for acute myocardial infarction during the 2012-2014 period, we examined the association between diabetes and the incidence and outcomes of cardiogenic shock complicating acute myocardial infarction, using multivariable logistic and linear regression models. Results: Of 1,332,530 hospitalizations for acute myocardial infarction, 72,765 (5.5%) were complicated ...
Background: Chronic kidney disease (CKD) is a strong risk factor for cardiovascular events, and there are consistence evidences about worse short- and long-term outcomes in CKD patients with acute myocardial infarction. The aim of this study was to evaluate the effects and safety of triple antiplatelet therapy (aspirin plus clopidogrel plus cilostazol) in CKD patients with ST-elevation myocardial infarction (STEMI) compared with dual antiplatelet therapy (aspirin plus clopidogrel).. Methods and results: Among over 21,000 patients in Korean Acute Myocardial Infarction Registry (KAMIR) data, 5,138 STEMI patients who underwent successful primary percutaneous coronary intervention with drug-eluting stents were enrolled in this study. They were divided by estimated creatinine clearance (eCrCl); ≥ 60 ml/min (n=3,445; dual = 2169, triple = 1276) and , 60 ml/min (n=1693; dual = 1120, triple = 573). Various major adverse cardiac events including major bleeding at 12 months were evaluated. The triple ...
TY - JOUR. T1 - Comparison of delay times between Symptom onset of an acute ST-elevation myocardial infarction and hospital arrival in men and women ,65 years versus ≥65 years of age. T2 - Findings from the multicenter Munich Examination of Delay in Patients Experiencing Acute Myocardial Infarction (MEDEA) study. AU - Ladwig, Karl-Heinz. AU - Fang, Xiaoyan. AU - Wolf, Kathrin. AU - Hoschar, Sophia. AU - Albarqouni, Loai. AU - Ronel, Joram. AU - Meinertz, Thomas. AU - Spieler, Derek. AU - Laugwitz, Karl-Ludwig. AU - Schunkert, Heribert. N1 - Copyright © 2017 Elsevier Inc. All rights reserved.. PY - 2017/12/15. Y1 - 2017/12/15. N2 - Early administration of reperfusion therapy in acute ST-elevation myocardial infarctions (STEMI) is crucial to reduce mortality. Although female sex and old age are key factors contributing to an inadequate long prehospital delay time, little is known whether women ≥65 years are a particular risk population. Hence, we studied the interaction of sex and age (,65 ...
TY - JOUR. T1 - Sonothrombolysis in ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention. AU - MRUSMI Investigators. AU - Mathias, Wilson. AU - Tsutsui, Jeane M.. AU - Tavares, Bruno G.. AU - Fava, Agostina M.. AU - Aguiar, Miguel O.D.. AU - Borges, Bruno C.. AU - Oliveira, Mucio T.. AU - Soeiro, Alexandre. AU - Nicolau, Jose C.. AU - Ribeiro, Henrique B.. AU - Chiang, Hsu Po. AU - Sbano, João C.N.. AU - Morad, Abdulrahman. AU - Goldsweig, Andrew. AU - Rochitte, Carlos E.. AU - Lopes, Bernardo B.C.. AU - Ramirez, José A.F.. AU - Kalil Filho, Roberto. AU - Porter, Thomas R.. PY - 2019/6/11. Y1 - 2019/6/11. N2 - Background: Preclinical studies have demonstrated that high mechanical index (MI)impulses from a diagnostic ultrasound transducer during an intravenous microbubble infusion (sonothrombolysis)can restore epicardial and microvascular flow in acute ST-segment elevation myocardial infarction (STEMI). Objectives: This study tested the clinical ...
I read the article by Yang JH,et al with great interest, in which the authors compared 1-year prognostic impacts of angiotensin receptor blockers (ARBs) with angiotensin converting enzyme inhibitors (ACEIs) in patients with ST segment elevation myocardial infarction (STEMI) with preserved left ventricular systolic function who underwent primary percutaneous coronary intervention (PCI) [1]. I believe it would be appreciated if authors discuss the long-term survival benefit of ARBs before concluding that ARBs are as beneficial as ACEIs in STEMI patients with preserved left ventricular systolic function after PCI.. Although ARBs could be an alternative to ACEIs, a recent observational study using inverse probability of treatment weighting and propensity score matching methods revealed that patients treated with ACEIs had significantly lower long-term mortality compared with those treated with ARBs from 2 to 5 years after acute myocardial infarction [2]. This study also demonstrated that crude ...
According to data from randomized, controlled trials, primary percutaneous coronary intervention (PCI) is the treatment of choice for ST-segment elevation myocardial infarction (MI). In these trials, 1 life was saved and 2 other life-threatening complications, including stroke and reinfarction, were prevented for every 50 patients with ST-segment elevation MI treated with primary PCI rather than thrombolytic therapy. Only 1 major bleeding episode occurred.. How can these superior results be realized outside the context of randomized trials? We anticipate 4 obstacles to instituting primary PCI as the universal treatment of ST-segment elevation MI: 1) lack of timely availability, 2) technical expertise of center and operator, 3) the need to address patient subgroups that are not studied in randomized trials, and 4) comparisons of primary PCI to newer pharmacologic regimens.. We propose 3 strategies to increase the availability of this procedure: 1) perform primary PCI in qualified community ...
TY - JOUR. T1 - Atrial fibrillation and risk of ST-segment-elevation versus non-ST-segment-elevation myocardial infarction the Atherosclerosis Risk in Communities (ARIC) study. AU - Soliman, Elsayed Z.. AU - Lopez, Faye. AU - ONeal, Wesley T.. AU - Chen, Lin Y.. AU - Bengtson, Lindsay. AU - Zhang, Zhu Ming. AU - Loehr, Laura. AU - Cushman, Mary. AU - Alonso, Alvaro. PY - 2015/5/26. Y1 - 2015/5/26. N2 - Background-It has recently been reported that atrial fibrillation (AF) is associated with an increased risk of myocardial infarction (MI). However, the mechanism underlying this association is currently unknown. Further study of the relationship of AF with the type of MI (ST-segment-elevation MI [STEMI] versus non-ST-segment-elevation MI [NSTEMI]) might shed light on the potential mechanisms. Methods and Results-We examined the association between AF and incident MI in 14 462 participants (mean age, 54 years; 56% women; 26% blacks) from the Atherosclerosis Risk in Communities (ARIC) study who ...
List of Tables. Table 1: Clinical subtypes of Indication. Table 2: Risk Factors. Table 3: Prevalence cases (%) Region wise. Table 4: Sources used for forecasting the data. Table 5: Myocardial Infarction Global Epidemiology, (2013-2023). Table 6: Prevalent Cases of Myocardial Infarction (Ages =XX Years), US (2013-2023). Table 7: Prevalent Cases of Myocardial Infarction By Sex (Males & Females), US (2013-2023). Table 8: Prevalent Cases By Myocardial Infarction Sub-population, US (2013-2023). Table 9: Prevalent Cases of Myocardial Infarction (Ages =XX Years), United Kingdom (2013-2023). Table 10: Prevalent Cases of Myocardial Infarction By Sex (Males & Females), United Kingdom (2013-2023). Table 11: Prevalent Cases By Myocardial Infarction Sub-population, United Kingdom (2013-2023). Table 12: Prevalent Cases of Myocardial Infarction (Ages =XX Years), Germany (2013-2023). Table 13: Prevalent Cases of Myocardial Infarction By Sex (Males & Females), Germany (2013-2023). Table 14: Prevalent Cases By ...
TY - JOUR. T1 - Comparison of outcomes of patients with painless versus painful ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention. AU - Cho, Jae Yeong. AU - Jeong, Myung Ho. AU - Ahn, Young Keun. AU - Kim, Jong Hyun. AU - Chae, Shung Chull. AU - Kim, Young Jo. AU - Hur, Seung Ho. AU - Seong, In Whan. AU - Hong, Taek Jong. AU - Choi, Dong Hoon. AU - Cho, Myeong Chan. AU - Kim, Chong Jin. AU - Seung, Ki Bae. AU - Chung, Wook Sung. AU - Jang, Yang Soo. AU - Cho, Seung Yun. AU - Rha, Seung Woon. AU - Bae, Jang Ho. AU - Cho, Jeong Gwan. AU - Park, Seung Jung. PY - 2012/2/1. Y1 - 2012/2/1. N2 - There are few data available on the prognosis of painless ST-segment elevation myocardial infarction (STEMI). The aim of this study was to determine the incidence, clinical characteristics, and outcomes of painless STEMI. We analyzed the Korea Acute Myocardial Infarction Registry (KAMIR) study, which enrolled 7,288 patients with STEMI (61.8 ± 12.8 years old, 74% men; ...
Aims. The TRA·CER trial compared vorapaxar, a novel platelet protease-activated receptor (PAR)-1 antagonist, with placebo in 12 944 patients with high-risk non-ST-segment elevation acute coronary syndromes (NSTE ACS). In this analysis, we explored the effect of vorapaxar on myocardial infarction (MI).. Methods and results. A blinded, independent central endpoint adjudication committee prospectively defined and classified MI according to the universal MI definition, including peak cardiac marker value (creatine kinase-MB [CK-MB] and/or troponin). Because the trial failed to meet its primary endpoint, these analyses are considered exploratory. During a median follow-up of 502 days, 1580 MIs occurred in 1319 patients. The majority (n = 1025, 64.9%) were type 1 (spontaneous) MI, followed by type 4a [percutaneous coronary intervention (PCI)-related] MI (n = 352; 22.3%). Compared with placebo, vorapaxar reduced the hazard of a first MI of any type by 12% [hazard ratio (HR), 0.88; 95% confidence ...
Since indium-111 platelet scintigraphy for the detection of left ventricular thrombosis often shows considerable non-specific blood pool activity a subtraction method using simultaneous technetium-99m blood pool scintigraphy was undertaken in 11 subjects with well documented remote myocardial infarction, who served as positive or negative controls, and in 18 consecutive patients with acute myocardial infarction. The results were compared with those of cross sectional echocardiography. Thirteen patients had transmural myocardial infarction and the calculated count per pixel in the left ventricle of the subtracted indium-111 platelet scintigram was (mean (SD)) 0.28(0.35), but five patients with subendocardial myocardial infarction had a mean count of 0.04(0.06). In seven patients with transmural myocardial infarction (two anterior and five inferior) left ventricular thrombosis was detected by indium-111 platelet scintigraphy but in only one of these by cross sectional echocardiography. None of the ...
TY - JOUR. T1 - Longitudinal trends in the severity of acute myocardial infarction. T2 - A population study in Olmsted County, Minnesota. AU - Hellermann, Jens P.. AU - Reeder, Guy S.. AU - Jacobsen, Steven J.. AU - Weston, Susan A.. AU - Killian, Jill M.. AU - Roger, Véronique L.. PY - 2002/8/1. Y1 - 2002/8/1. N2 - The mechanisms of the decline in coronary heart disease mortality are not fully elucidated. In particular, little is known about the trends in severity of myocardial infarction, which may have contributed to the mortality decline. This study examines indicators of myocardial infarction severity including Killip class, electrocardiogram descriptors, and peak creatine kinase values in a population-based, myocardial infarction incidence cohort to test the hypothesis that the severity of myocardial infarction declined over time. Between 1983 and 1994, 1,295 incident cases of myocardial infarction (mean age, 67 (standard deviation, 6) years; 43% women) occurred in Olmsted County, ...
On- vs. off-hours admission of patients with ST-elevation acute myocardial infarction undergoing percutaneous coronary interventions: data from a tertiary university brazilian hospital
Introduction: ST Segment Elevation Myocardial Infarction (STEMI) is largely due to plaque rupture (60-70% of cases) and plaque erosion (30-40%). Coronary inflammation plays a pivotal role in rupture, but the pathophysiology of erosion is unknown. Autopsy studies have shown that inflammatory infiltrates are much less abundant in erosion compared to rupture. We explored the hypothesis that differences in intracoronary cytokines can be demonstrated in vivo in the early phase of STEMI in patients undergoing primary percutaneous coronary intervention (PPCI).. Methods: We recruited 40 STEMI patients undergoing PPCI with in less than 6 hours of chest pain in a single-centre observational study. Blood samples were taken from the infarct-related artery using thrombus aspiration. Culprit plaques were imaged using optical coherence tomography (OCT) before PCI and classified by two blinded observers. The expression profiles of 102 cytokines were measured using an array, and comparisons of the two ...
Emerging evidence indicate that progenitor stem cells derived from bone marrow can be used to improve cardiac function in acute myocardial infarction patients. There is a great potential for stem cell therapy, using a variety of cell precursors to contribute to new blood vessel formation and muscle preservation in the myocardial infarct zone. The administration of cells via an infusion through the infarct related artery appears to be feasible and result in a clinical effect in some studies. Across the globe AMI is the leading cause of morbidity and mortality. This cannot be prevented by optimal standard therapies i.e. balloon or stent dilation of the infarct vessels.. The study is a double blind, placebo controlled, randomized, multicenter trial. Male or female patients between 18-75 years with first incidence of Acute Myocardial Infarction(AMI) and LVEF less than or equal to 40% are included in the study. Patients who have undergone successful percutaneous intervention (PCI) within ≤ 24 hours ...
TY - JOUR. T1 - Assisted ventilation during bystander CPR in a swine acute myocardial infarction model does not improve outcome. AU - Berg, Robert A.. AU - Kern, Karl B.. AU - Hilwig, Ronald W.. AU - Ewy, Gordon A.. PY - 1997/1/1. Y1 - 1997/1/1. N2 - Background: Mouth-to-mouth rescue breathing is a barrier to the performance of bystander cardiopulmonary resuscitation (CPR). We evaluated the need for assisted ventilation during simulated single-rescuer bystander CPR in a swine myocardial infarction model of prehospital cardiac arrest. Methods and Results: Steel cylinders were placed in the mid left anterior descending coronary arteries of 43 swine. Two minutes after ventricular fibrillation, animals were randomly assigned to 10 minutes of hand-bag-valve ventilation with 17% oxygen and 4% carbon dioxide plus chest compressions (CC+V), chest compressions only (CC), or no CPR (control group). Standard advanced life support was then provided. Animals successfully resuscitated received 1 hour of ...
RRH: Rural and Remote Health. Published article number: 2013 - Thrombolysis for acute ST elevation myocardial infarction: a pilot study comparing results from GP led small rural health emergency departments with results from a physician led sub-regional emergency department
Objectives. This study was designed to reassess the prediction of recurrent nonfatal myocardial infarction in patients recovering from acute myocardial infarction after thrombolysis.. Background. Recurrent nonfatal myocardial infarction is a strong and independent predictor of subsequent mortality. Current knowledge of risk factors for nonfatal reinfarction is still largely based on data gathered before the advent of thrombolysis. Thus, this prospective study was planned to identify harbingers of nonfatal reinfarction in the postinfarction patients of the multicenter Gruppo Italiano per lo Studio della Sopravvivenza nellInfarto Miocardico (GISSI-2) trial.. Methods. Predictors of nonfatal reinfarction at 6 months were analyzed by multivariate technique (Cox model) in 8,907 GISSI-2 survivors of myocardial infarction with clinical follow-up, relying on a set of prespecified variables reflecting residual ischemia, left ventricular failure or dysfunction, complex ventricular arrhythmias, comorbidity ...
Methods All studies published on the risk of MI during OC2 and OC3 use were analysed. For DVT the Committee for Proprietary Medicinal Products public assessment report published in 2001 and more recent studies published on this topic were used. The estimates of odds ratios (OR) for risk of death from DVT or MI were extracted from the published manuscripts. ORs were used to calculate the aetiological fraction of risk for death from DVT and MI in the population; the relative impact of OC3 compared to OC2 use was expressed as an excess risk of death overall and by age group for French women.. ...
1. Aronson D, Nassar M, Goldberg T, Kapeliovich M, Hammerman H, Azzam ZS. The impact of body mass index on clinical outcomes after acute myocardial infarction. Int J Cardiol. 2010;145:476-480. doi: 10.1016/j.ijcard.2009.12.029 20096942. 2. Kang WY, Jeong MH, Ahn YK, Kim JH, Chae SC, Kim YJ, et al. Obesity paradox in Korean patients undergoing primary percutaneous coronary intervention in ST-segment elevation myocardial infarction. J Cardiol. 2010;55:84-91. doi: 10.1016/j.jjcc.2009.10.004 20122553. 3. Kragelund C, Hassager C, Hildebrandt P, Torp-Pedersen C, Kober L. Impact of obesity on long-term prognosis following acute myocardial infarction. Int J Cardiol. 2005;98:123-131. 15676176. 4. Lazzeri C, Valente S, Chiostri M, Attana P, Picariello C, Sorini Dini C, et al. Impact of age on the prognostic value of body mass index in ST-elevation myocardial infarction. Nutr Metab Cardiovasc Dis. 2013;23:205-211. doi: 10.1016/j.numecd.2012.05.013 22901842. 5. OBrien EC, Fosbol EL, Peng SA, Alexander KP, ...
|p|The 12-lead surface electrocardiogram adjacent QTc dispersion, which is the maximum difference of corrected QT interval between two adjacent leads, is a simple method to determine regional variation in repolarization and refractoriness. The aim of this study is to evaluate adjacent QTc dispersion as a marker of susceptibility to ventricular arrhythmias after myocardial infarction. A total of 135 consecutive patients with acute myocardial infarction were enrolled in the study. Adjacent QTc, measured by lens magnifier, was calculated on the first, second and third days after acute myocardial infarction. On the second day after acute myocardial infarction, adjacent QTc dispersion was significantly greater in patients with ventricular arrhythmias (P < 0.001). Adjacent QTc dispersion on the first and fifth day after acute myocardial infarction was not associated with development of ventricular arrhythmias. On the second day after acute myocardial infarction, adjacent QTc dispersion is
No beneficial effect of intravenous enalaprilat followed by oral enalapril on mortality when administered within 24 hours post myocardial infarction. It is important to note in this study that follow-up was for 6 months only, possibly missing a late benefit due to ACE inhibitor therapy. The benefit of ACE inhibition appears most prominent for patients with anterior myocardial infarctions. This was a non-selective post myocardial infarction study without heart failure or left ventricular dysfunction on entry criterion. In ISIS-4 and GISSI-3, mortality improved by 0.46% and 0.8%, respectively, with risk reductions of 9% and 11%. In view of the risk of hypotension (20% in ISIS-4, compared with placebo 10%), very early ACE inhibition may benefit a highly selected subset of patients.. ...
Objective - The cause of increased post-AMI (acute myocardial infarction) mortality associated with depression remains poorly elucidated. The objective of this study was to examine the extent to which self-reported cardiac functional status accounted for depression-mortality associations following AMI.. Methods - Using a prospective cohort design (n = 1941), the authors obtained self-reported measures of depression and developed profiles of the patients pre-hospitalization cardiac risks, co-morbid conditions and drugs and revascularization procedures during or following index AMI hospitalization. To create these profiles, the patients self-reports were retrospectively linked to no less than 12 years worth of previous hospitalization data. Mortality rates 2 years after acute MI were examined with and without sequential risk adjustment for age, sex, income, cardiovascular risk, co-morbid conditions, selected process-of-care factors and self-reported cardiac functional status.. Results - ...
Whereas thrombus aspiration in patients with ST-elevation myocardial infarction (STEMI) is recommended by current guidelines, there are insufficient data to unequivocally support thrombectomy in patients with non-STEMI (NSTEMI). The Thrombus Aspiration in ThrOmbus containing culpRiT lesions in Non-ST-Elevation Myocardial Infarction (TATORT-NSTEMI) trial is a 400 patient, prospective, controlled, multicenter, randomized, open-label trial. The hypothesis is that under the background of early revascularization, adjunctive thrombectomy in comparison to conventional percutaneous coronary intervention (PCI) alone leads to less microvascular obstruction (MO) assessed by cardiac magnetic resonance imaging (CMR) in patients with NSTEMI. Patients will be randomized in a 1:1 fashion to one of the two treatment arms. The primary endpoint is the extent of MO assessed by CMR. Secondary endpoints include infarct size and myocardial salvage assessed by CMR, enzymatic infarct size as well as angiographic ...
Acute Myocardial infarction (AMI) at a young age (below 45 years) is rare and difficult to predict. We reported a fatal myocardial infarction from advanced atherosclerosis in a healthy young man who had no other major coronary risk factors except mild hypercholesterolemia. Thus, all available systemic risk scores identified him as a low risk candidate for developing a cardiovascular event. Autopsy revealed advanced atherosclerosis in all three major coronary arteries causing acute and old myocardial infarction. Thick epicardial adipose tissue and myocardial bridging of the mid left anterior descending artery were also noted. He frequently used etoricoxib to treat knee and back pain for consecutive five years. Potential mechanisms of sudden death from atherosclerosis, myo- cardial bridging, epicardial adipose tissue and selective COXIB are discussed in more detail below.. ...
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Title:Intracoronary Injection of Glycoprotein IIb/IIIa, Abciximab, as Adjuvant Therapy in Primary Coronary Intervention. VOLUME: 11 ISSUE: 2. Author(s):Andrea Rognoni, Alessadro Lupi, Chiara Cavallino, Roberta Rosso, Alessia Veia, Sara Bacchini and Angelo Sante Bongo. Affiliation:Coronary Care Unit and Catheterization Laboratory, Hospital Maggiore della Carita, Corso Mazzini 18, 28100 Novara, Italy.. Keywords:STEMI, Acute coronary syndrome, adjuvant therapy, bleeding, GP IIb/IIIa inhibitors, in - stent restenosis, no - reflow phenomenon, percutaneous coronary intervention, platelet, thrombosis.. Abstract:Acute coronary syndromes and, in paticular, ST - segment elevation myocardial infarction are the principle causes or mortality and morbidity in the industrialized countries. The manadgement of acute myocadial infarction is much debated in the literature; primary percutaneous coronary intervention is the treatment of choice. In the recent years there has been an increasing interest in the ...
The objectives are to examine if the excess risk of myocardial infarction from exposure to job strain is due to interaction between high demands and low control and to analyse what role such an interaction has regarding socioeconomic differences in risk of myocardial infarction. The material is a population-based case-referent study having...
Patients with symptoms suggestive of an acute myocardial infarction (MI) and having electrocardiographic evidence of an acute MI manifested by ST elevations (>1 mm in two contiguous leads afterto rule out coronary vasospasm) that is considered to rep
Patients with symptoms suggestive of an acute myocardial infarction (MI) and having electrocardiographic evidence of an acute MI manifested by ST elevations (>1 mm in two contiguous leads afterto rule out coronary vasospasm) that is considered to rep
Symptom-to-door time in ST segment elevation myocardial infarction: overemphasized or overlooked? Results from the AMI-McGill study. Can J Cardiol. 2008 Mar; 24(3):213-6 ...
Background. Acute myocardial infarction is a major cause of death and morbidity worldwide, both in women and in men. Up to the age of 70 the incidence of acute myocardial infarction is higher in men than in women. Although the incidence is lower in young women than in young men, young women are particularly vulnerable due to higher fatality rates. The lower incidence in women compared to men might underestimate womens risk. Women might also be less likely to identify themselves as possible sufferers and to take cardio-protective actions.. The treatment of acute myocardial infarction has changed dramatically the last decades and reperfusion therapy has great impact on myocardial damage. The most critical time of an acute myocardial infarction is the very early phase, as rapid treatment is significantly associated with reduced mortality. Time has therefore become an important issue regarding the patients prognosis. These patients often delay in seeking medical assistance, and this patient ...
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SUMMARY A seasonal pattern with winter peak in acute myocardial infarction incidence and cardiovascular disease risk factors is observed in studies worldwide. However, several previous studies have methodical limitations and few are performed in cold climate areas. The aim of this thesis is to assess the effect of season and meteorological factors on first-ever myocardial infarction and the seasonal variation in cardiovascular disease risk factors in a subarctic adult population with long-term follow-up, using appropriate methods with adjudicated outcomes and well-defined exposures. The population-based Tromsø Study consists of more than 40,000 individuals living in a subarctic climate in Northern Norway. The cohort members have been examined up to nine times in six repeated health surveys in the years between 1974 and 2008. Data on myocardial infarction and risk factors have been collected throughout follow-up. The thesis consists of three studies. The first study is an analysis of the ...
TY - JOUR. T1 - Risk stratification after acute myocardial infarction by means of exercise two-dimensional echocardiography. AU - Ryan, Thomas. AU - Armstrong, William F.. AU - ODonnell, Jacqueline A.. AU - Feigenbaum, Harvey. PY - 1987/12. Y1 - 1987/12. N2 - To determine whether exercise two-dimensional echocardiography contributes to the prognostic information provided by exercise testing in patients recovering from acute myocardial infarction, 40 patients were prospectively studies by means of pre- and postexercise echocardiography 10 to 21 days after myocardial infarction. Patients were followed for 6 to 10 months or until one of the following clinical end points occurred: death, recurrent myocardial infarction, unstable angina, or coronary artery bypass grafting. Results of treadmill exercise tests were negative in 13 of 20 patients with good clinical outcome (65% specificity) and positive in 11 of 20 patients with poor clinical outcome (55% sensitivity). The resting echocardiogram was ...
OBJECTIVE--The SAVE study showed that captopril improves mortality in patients with left ventricular dysfunction after myocardial infarction and that this benefit occurred even in patients with no clinically overt heart failure. On the basis of this, it seems important to identify correctly which patients have left ventricular dysfunction after a myocardial infarction. The objective was to compare various methods of identifying patients with left ventricular dysfunction (left ventricular ejection fraction, LVEF, , or = 40%) after acute myocardial infarction. The methods compared were echocardiography (quantitative and qualitative visual assessment), clinical evaluation (subjective assessment and three clinical score methods), and measurement of plasma concentrations of cardiac natriuretic peptide hormones (atrial and brain natriuretic peptides, ANP and BNP). DESIGN--Cross sectional study of left ventricular function in patients two to eight days after acute myocardial infarction. ...
Background and Objectives: Metabolic syndrome (MetS) is an important risk factor for cardiovascular disease. However, the clinical outcome of acute myocardial infarction (AMI) with MetS has not been well examined. The purpose of this study was to evaluate the clinical outcomes of AMI patients with MetS. Subjects and Methods: We evaluated a total of 6352 AMI patients who had successful percutaneous coronary interventions and could be identified for MetS between 2005 and 2008 at 51 hospitals participating in the Korea Acute Myocardial Infarction Registry. They were divided into 2 groups according to the presence of MetS: the MetS group (n=2493, 39.2%) versus the Non-MetS group (n=3859, 60.8%). In addition, 4049 AMI patients with high levels of low density lipoprotein-cholesterol (LDL-C) (��100 mg/dL) among them, were divided into the MetS group (n=1561, 38.6%) versus the Non-MetS group (n=2488, 61.4%). Results: In the overall population, there was no significant difference in 12-month the ...
The HELP-AMI (Hepacoat for Culprit or Multivessel Stenting for Acute Myocardial Infarction) trial randomized 69 patients in a 3:1 ratio to MV or CVO primary PCI (17). There was a nonsignificant reduction in repeat revascularization with MV primary PCI (17% vs. 35%), but no differences in death or reinfarction rates.. Politi et al. (18) randomized 214 patients to CVO primary PCI, MV primary PCI, or staged PCI. Again, repeat revascularization rates were lower with MV primary PCI, but there were no differences in death or reinfarction rates.. The PRAMI (Preventive Angioplasty in Acute Myocardial Infarction) trial screened 1,922 patients and enrolled 465 patients at 5 sites over 5 years (16). Recruitment was stopped prematurely by the data safety and monitoring board with a mean follow-up of 23 months due to significant differences between groups. The sample size was on the basis of an expected annual MACE rate of 20% for CVO primary PCI and a 30% risk reduction for MV primary PCI at 80% power. ...
Heart attack treatment may involve primary percutaneous transluminal coronary angioplasty (PTCA). Heart attack treatment information developed by physicians.
TY - JOUR. T1 - Survival of patients undergoing rescue percutaneous coronary intervention. AU - Burjonroppa, Sukesh C.. AU - Varosy, Paul D.. AU - Rao, Sunil V.. AU - Ou, Fang Shu. AU - Roe, Matthew. AU - Peterson, Eric. AU - Singh, Mandeep. AU - Shunk, Kendrick A.. PY - 2011/1. Y1 - 2011/1. N2 - Objectives This study sought to develop a tool for predicting an individuals risk of mortality following rescue percutaneous coronary intervention (PCI). Background Although fibrinolytic therapy is appropriate and improves survival for certain ST-segment elevation myocardial infarction patients, a substantial proportion suffer ongoing myocardial ischemia, a class I indication for emergent percutaneous coronary intervention (rescue PCI). Methods Using the National Cardiovascular Data Registry (NCDR), rescue PCI was defined as nonelective PCI following failed fibrinolysis in patients with continuing or recurrent myocardial ischemia. Multivariable logistic regression was used to determine mortality ...
Acute coronary syndrome continues to be a significant cause of morbidity and mortality in the United States. Family physicians need to identify and mitigate risk factors early, as well as recognize and respond to acute coronary syndrome events quickly in any clinical setting. Diagnosis can be made based on patient history, symptoms, electrocardiography findings, and cardiac biomarkers, which delineate between ST elevation myocardial infarction and non-ST elevation acute coronary syndrome. Rapid reperfusion with primary percutaneous coronary intervention is the goal with either clinical presentation. Coupled with appropriate medical management, percutaneous coronary intervention can improve short- and long-term outcomes following myocardial infarction. If percutaneous coronary intervention cannot be performed rapidly, patients with ST elevation myocardial infarction can be treated with fibrinolytic therapy. Fibrinolysis is not recommended in patients with non-ST elevation acute coronary syndrome;
TY - JOUR. T1 - What is the best anticoagulant therapy during primary percutaneous coronary intervention for acute myocardial infarction?. AU - Gurbel, Paul A.. AU - Navarese, Eliano Pio. AU - Tantry, Udaya S.. N1 - Publisher Copyright: Copyright © by Medycyna Praktyczna, Kraków 2015.. PY - 2015. Y1 - 2015. N2 - Both ST-segment elevation myocardial infarction and percutaneous coronary intervention (PCI) are associated with a highly prothrombotic state, and thrombin plays a critical role during occlusive clot generation and subsequent occurrence of an ischemic event. Therefore, a strategy of anticoagulation plus dual antiplatelet therapy has been regarded as de facto standard therapy during primary PCI (pPCI). Recently, there has been great controversy surrounding the role of bivalirudin versus unfractionated heparin in pPCI. Earlier, the results of the HORIZONS-AMI trial, particularly those regarding the long-lasting mortality benefit, provided a strong rationale for recommending bivalirudin ...
OBJECTIVES: This study sought to evaluate the effect of early intravenous metoprolol on left ventricular (LV) strain assessed with feature-tracking cardiovascular magnetic resonance (CMR). BACKGROUND: Early intravenous metoprolol before primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) portends better outcomes in the METOCARD-CNIC (Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction) trial. METHODS: A total of 197 patients with acute anterior STEMI who were enrolled in the METOCARD-CNIC trial (100 allocated to intravenous metoprolol before primary PCI and 97 control patients) were evaluated. LV global circumferential strain (GCS) and global longitudinal strain (GLS) were measured with feature-tracking CMR at 1 week and 6 months after STEMI and compared between randomization groups. RESULTS: Patients who received early intravenous metoprolol had significantly more preserved LV strain compared with the control patients ...
Arachidonic acid (AA), a precursor of prothrombotic eicosanoids, is potentially atherogenic, but epidemiologic data are scarce. We evaluated the hypothesis that increased AA in adipose tissue is associated with increased risk of nonfatal acute myocardial infarction (MI), and if so, whether this association is related to dietary or adipose tissue linoleic acid. We studied the association between AA and MI in 466 cases of a first nonfatal acute MI, matched on age, gender, and residence to 466 population controls. Fatty acids (FA) were assessed by GC in adipose tissue samples collected from all subjects. Odds ratios (OR) and 95% CI were calculated from multivariate conditional logistic regression models. Subjects in the highest quintile of adipose tissue AA (0.64% of total FA) had a higher risk of nonfatal acute MI than those in the lowest quintile (0.29% of total FA), after adjusting for potential confounders including (n-3) and trans FAs (OR=1.94, 95% CI: 1.07, 3.53, P for trend = 0.026). Adipose ...
TY - JOUR. T1 - Pentraxin 3 in unstable angina and non-ST-segment elevation myocardial infarction. AU - Matsui, Shigeru. AU - Ishii, Junichi. AU - Kitagawa, Fumihiko. AU - Kuno, Atsuhiro. AU - Hattori, Kousuke. AU - Ishikawa, Makoto. AU - Okumura, Masanori. AU - Kan, Shino. AU - Nakano, Tadashi. AU - Naruse, Hiroyuki. AU - Tanaka, Ikuko. AU - Nomura, Masanori. AU - Hishida, Hitoshi. AU - Ozaki, Yukio. PY - 2010/5/1. Y1 - 2010/5/1. N2 - Purpose: We prospectively investigated the prognostic value of pentraxin 3 (PTX3) in patients with unstable angina and non-ST-segment elevation myocardial infarction (UA/NSTEMI). Background: PTX3 may be a useful marker for localized vascular inflammation and damage to the cardiovascular system. Recent studies have shown that plasma PTX3 is elevated in patients with UA/NSTEMI; however, its prognostic value in UA/NSTEMI remains unclear. Methods: PTX3, high-sensitivity C-reactive protein (hsCRP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and cardiac ...
TY - JOUR. T1 - Resuscitative endovascular balloon occlusion of the aorta during non-ST elevation myocardial infarction. T2 - A case report. AU - Curtis, Eleanor E.. AU - Russo, Rachel M.. AU - Nordsieck, Eric. AU - Johnson, Michael. AU - Williams, Timothy K.. AU - Neff, Lucas P.. AU - Hile, Lisa. AU - Galante, Joseph M. AU - Dubose, Joseph J.. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a hemorrhage control technique that is increasingly being adopted for the management of noncompressible bleeding. In addition to limiting hemorrhage, REBOA increases blood flow to the heart, lungs, and brain. A small number of case reports and animal studies describe the use of REBOA to increase coronary perfusion during cardiopulmonary resuscitation. We report a case in which REBOA may have reversed ST-segment abnormalities during a Type II non-ST elevation myocardial infarction (NSTEMI) in a patient with previous trauma. We describe the presentation, ...
TY - JOUR. T1 - Echocardiography in acute myocardial infarction.. AU - Quinones, M. A.. PY - 1984/2. Y1 - 1984/2. N2 - Echocardiography has recently gained increasing popularity as a noninvasive technique to assess left ventricular function and regional wall motion in acute myocardial infarction. Detection of regional dyssynergy is possible in over 90 per cent of patients with acute infarction, allowing assessment of site and extent of involvement. Estimates of severity of left ventricular dysfunction on admission into the coronary care unit allow stratification of patients into risk categories in terms of acute and long-term prognosis. Complications of myocardial infarction such as right ventricular infarction, ventricular septal rupture, papillary muscle rupture, papillary muscle dysfunction, formation of mural thrombi, ventricular aneurysms, and pericardial effusion can be diagnosed echocardiographically at the bedside. This article discusses these applications as well as some of the ...
Amin AP, Salisbury AC, McCullough PA, et al. Trends in the incidence of acute kidney injury in patients hospitalized with acute myocardial infarction. Arch Intern Med. 2012;172:246-253. Available at: Hsu RK, Hsu C. Acute kidney injury: comment on Trends in the incidence of acute kidney injury in patients hospitalized with acute myocardial infarction. Arch Intern Med. 2012;172:253-254.. Parikh CR, Coca SG, Wang Y, et al. Long-term prognosis of acute kidney injury after acute myocardial infarction. Arch Intern Med. 2008;168:987-995.. Aengus Murphy C, Robb SD, Weir RA, et al. Declining renal function after myocardial infarction predicts poorer long-term outcome. Eur J Cardiovasc Prev Rehabil. 2010;17:181-186.. Chertow GM, Burdick E, Honour M, et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005;16:3365-3370.. Molitoris BA, Levin A, Warnock DG; et al, Acute Kidney Injury Network ...
It is now widely accepted that for patients with ST-segment elevation myocardial infarction (STEMI), primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy if it can be delivered in a timely fashion. Based on robust evidence documenting a relationship between time-to-reperfusion (defined either by time between symptom onset or hospital arrival and reperfusion) and mortality (1,2), the American College of Cardiology/American Heart Association guidelines recommend that STEMI patients undergo primary PCI with a balloon inflation or device time within 90 min of first medical contact (3). Moreover, in the most recent focused update of the STEMI guidelines, it is recommended that each community develop a STEMI system of care that includes: 1) a process for pre-hospital identification of STEMI and catheterization laboratory activation; 2) destination protocols for STEMI-receiving centers; and 3) transfer protocols for patients who arrive at STEMI referral centers and are ...
Summary Circulating procoagulant microparticles (MP) were measured as markers of vascular damage and prothrombotic risk in patients undergoing ST-segment myocardial infarction (STEMI) treated by primary percutaneous transluminal coronary angioplasty (PTCA) and additional GPIIb-IIIa antagonists. Cel...
Bed rest is an inherent part of treatment for acute myocardial infarction (AMI). In clinical practice this intervention is prescribed in different ways and for different lengths of time. Current guidelines recommend at least 12 hours bed rest following AMI. However the basis for these recommendations is unclear. This review found 15 trials which were generally outdated and of moderate to poor methodological quality. Bed rest ranging from 2 to 12 days appears to be as safe as longer periods of bed rest. No evidence was found to support the current bed rest recommendations of not more than 12 to 24 hours. The optimal duration of bed rest after AMI remains undetermined from the available evidence.. ...
ENGLISH ABSTRACT: A heart attack is a medical emergency and a life threatening disease. Patients with chest pain and a possible diagnosis of myocardial infarction require a detailed assessment and prompt medical management. The aim of the study was to determine the in-hospital delay in administrating thrombolytic therapy to patients with acute myocardial infarction (AMI) A mixed method with convergent parallel design was applied to the study. The population consisted of N=63 case notes of adult patients diagnosed with acute myocardial infarction and who had received thrombolytic therapy. The other population included (n=8) registered professional nurses working in the coronary care unit (CCU) of a tertiary hospital in the Western Cape. A record review was done using a data extraction form and semi-structured interview guide was used for data collection purposes. Reliability and validity was tested by the use of a nurse expert and a statistician. The nurse expert evaluated the data extraction ...
TY - JOUR. T1 - High Exercise Capacity Attenuates the Risk of Early Mortality After a First Myocardial Infarction. T2 - The Henry Ford Exercise Testing (FIT) Project. AU - Shaya, Gabriel E.. AU - Al-Mallah, Mouaz H.. AU - Hung, Rupert K.. AU - Nasir, Khurram. AU - Blumenthal, Roger S.. AU - Ehrman, Jonathan K.. AU - Keteyian, Steven J.. AU - Brawner, Clinton A.. AU - Qureshi, Waqas T.. AU - Blaha, Michael J.. PY - 2016/2/1. Y1 - 2016/2/1. N2 - Objective To examine the effect of objectively measured exercise capacity (EC) on early mortality (EM) after a first myocardial infarction (MI). Patients and Methods This retrospective cohort study included 2061 patients without a history of MI (mean age, 62±12 years; 38% [n=790] women; 56% [n=1153] white) who underwent clinical treadmill stress testing in the Henry Ford Health System from January 1, 1991, through May 31, 2009, and suffered MI during follow-up (MI event proportion, 3.4%; mean time from the exercise test to MI, 6.1±4.3 years). Exercise ...
A 41-year-old male bodybuilder was admitted with acute inferior myocardial infarction. The patient had been using oxymetholone and methenolone to increase his performance for 15 years and quitted smoking three years before. He underwent successful primary percutaneous coronary intervention (PCI) and …
The dilemma of refractory hypoxemia after inferior wall myocardial infarction. Proc (Bayl Univ Med Cent). 2018 Jan;31(1):67-69 Authors: Albaghdadi A, Teleb M, Porres-Aguilar M, Porres-Munoz M, Marmol-Velez A Abstract Patent foramen ovale (PFO) occurs in 25% of people. The decision on whether to close the PFO found after myocardial infarction and specifically right ventricular...
OBJECTIVES: Our goal was to validate myocardium at risk on T2-weighted short tau inversion recovery (T2-STIR) cardiac magnetic resonance (CMR) over time, compared with that seen with perfusion single-photon emission computed tomography (SPECT) in patients with ST-segment elevation myocardial infarction, and to assess the amount of salvaged myocardium after 1 week. BACKGROUND: To assess reperfusion therapy, it is necessary to determine how much myocardium is salvaged by measuring the final infarct size in relation to the initial myocardium at risk of the left ventricle (LV). METHODS: Sixteen patients with first-time ST-segment elevation myocardial infarction received (99m)Tc tetrofosmin before primary percutaneous coronary intervention. SPECT was performed within 4 h and T2-STIR CMR within 1 day, 1 week, 6 weeks, and 6 months. At 1 week, patients were injected with a gadolinium-based contrast agent for quantification of infarct size. RESULTS: Myocardium at risk at occlusion on SPECT was 33 +/- ...
Background In-stent restenosis is considered to be a gradual and progressive condition and there is scant data on myocardial infarction (MI) as a clinical presentation. Methods and Results Of 2,462 consecutive patients who underwent percutaneous coronary intervention between June 2001 and December 2002, clinical in-stent restenosis occurred in 212 (8.6%), who were classified into 3 groups: ST elevation MI (STEMI), non-ST elevation MI (NSTEMI) and non-MI. Of the 212 patients presenting with clinical in-stent restenosis, 22 (10.4%) had MI (creatine kinase (CK) ≥2 × baseline with elevated CKMB). The remaining 190 (89.6%) patients had stable angina or evidence of ischemia by stress test without elevation of cardiac enzymes. Median interval between previous intervention and presentation for clinical in-stent restenosis was shorter for patients with MI than for non-MI patients (STEMI, 90 days; NSTEMI, 79 days; non-MI, 125 days; p=0.07). Diffuse in-stent restenosis was more frequent in MI patients ...
Background. Emerging evidence suggests that stem cells and progenitor cells derived from bone marrow can be used to improve cardiac function in patients after acute myocardial infarction. In this randomised trial, we aimed to assess whether intracoronary transfer of autologous bone-marrow cells could improve global left-ventricular ejection fraction (LVEF) at 6 months follow-up.. Methods. After successful percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction, 60 patients were randomly assigned to either a control group (n=30) that received optimum postinfarction medical treatment, or a bone-marrow-cell group (n=30) that received optimum medical treatment and intracoronary transfer of autologous bone-marrow cells 4·8 days (SD 1·3) after PCI. Primary endpoint was global left-ventricular ejection fraction (LVEF) change from baseline to 6 months follow-up, as determined by cardiac MRI. Image analyses were done by two investigators blinded for treatment ...
BACKGROUND: Chronic kidney disease is associated with increased risk of mortality. We examined the impact of moderate and severe renal insufficiency (RI) on short- and long-term mortality among unselected patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). METHODS: From January 1, 2002 to December 31, 2010 all patients with STEMI treated with primary PCI were identified. The hazard ratio (HR) for death was estimated using a Cox regression model, controlling for potential confounders. RI was defined as creatinine clearance (CrCl) , 60 mL/min (moderate RI: CrCl ≤30 , 60 mL/min and severe RI: CrCl , 30 mL/min). RESULTS: The study cohort consisted of 4,116 patients of whom 898 (21.8%) had RI and 3,218 (78.2%) had a CrCl ≥ 60 mL/min. Compared to patients without RI, patients with RI were older, more often female and more likely to have diabetes mellitus, hypertension and to present with a higher Killip class.Among ...
Acute myocardial infarction (AMI) is one of the most deleterious conditions leading to cardiovascular diseases and mortality. The importance of an early and accurate diagnosis assures immediate medical treatments, which are fundamental to reduce mortality and improve prognoses. AMI is associated to an inflammatory response which includes the increase of circulating inflammatory cytokines, chemokines and immune cell activation. This study aimed to identify which are the very early immune-related biomarkers that may be used as predictors of myocardial infarction severity. In order to mimic the pathophysiological events involved in human myocardial infarction, a temporary occlusion (90 min) of the mid-left anterior descending coronary artery was performed in a swine animal model. Lymphocyte subsets analysis in peripheral blood revealed significant alterations in CD4+/CD8+ ratio and naïve and effector/memory T cell percentages at 1 h post-myocardial infarction. Changes in TH1/TH2-related cytokine, monocyte
Aims: IL-1b-3953 C,T and MMP-9-1562C,T variants have been shown to be linked to the development of myocardial infarction (MI), although previous studies have reported inconsistent results. The aim of the present study was to determine whether these genetic variations are associated with MI susceptibility in an Iranian population. Methods: In the current study, 117 patients with MI and 120 control group members were selected as participants. Peripheral blood samples were taken from all the subjects for genomic DNA extraction. Single nucleotide polymorphism (SNP) genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assays. Results: Multiple logistic regression analysis revealed that the TT genotype of the IL-1b-3953 C,T polymorphism is associated with a significant MI protective effect in: the homozygote model after adjustment for MI risk factors (odds ratio OR]: 0.18, confidence interval 95% CI] = 0.04-0.72; p = 0.01); and also in the recessive ...
Background Recent trials in acute myocardial infarction indicate that intensive and early statin therapy that lowers low-density lipoprotein cholesterol (LDL-C) to ≤ 70 mg dL−1 is beneficial. The combination of statins with ezetimibe, a newly developed cholesterol-absorption inhibitor, can lead to a further reduction in LDL-C of up to 26%. In this study, we examined the rapidity and intensity of the lipid-lowering effect of ezetimibe co-administered with simvastatin immediately after myocardial infarction.. Materials and methods Sixty patients admitted for acute myocardial infarction were randomized to receive either simvastatin 40 mg (SIMVA), a combination of simvastatin 40 mg and ezetimibe 10 mg (EZE/SIMVA), or no lipid-lowering drugs (NLLD) and had their lipid levels assessed 2, 4 and 7 days later.. Results At baseline, cardiovascular risk factors were similar in all three groups [mean (SD) LDL-C of 141 (36) mg dL−1]. At days 2 , 4 and 7 there was no significant change in mean LDL-C ...
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was as follows: is coronary artery bypass graft (CABG) surgery superior to percutaneous coronary intervention (PCI) in terms of in Show moreA best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was as follows: is coronary artery bypass graft (CABG) surgery superior to percutaneous coronary intervention (PCI) in terms of in-hospital mortality and morbidity and long-term outcomes in patients with acute myocardial infarction (MI)? A total of 104 papers were returned using the selected search. Of these, six represented the best evidence to answer the clinical question. The selection criteria were comparative studies with only PCI and CABG groups in patients with acute MI. Case reports, reviews, recommendations and studies on a specific population or out of the context of acute MI were excluded. The authors, journal, date and country ...
Periprocedural myocardial infarction enhances the predictive value of inflammatory biomarkers for patients with obstructive coronary artery disease after implantation of drug-eluting stent Anastasia Jesika,1 Zuo-Ying Hu,2 Jing Kan,3 Shao-Liang Chen2 1Nanjing Medical University, Nanjing, Peoples Republic of China; 2Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Peoples Republic of China; 3Nanjing Heart Center, Nanjing, Peoples Republic of China Objective: The present study aims to clarify the long-term clinical importance of interleukin (IL)-6 in predicting major adverse cardiac events (MACE) for an entire cohort of patients with coronary artery disease after implantation of a drug-eluting stent (DES), and its interplay with periprocedural myocardial infarction (PMI). Background: The correlation of proinflammatory biomarkers with occurrence of clinical events, including PMI and mortality, is controversial. Methods: IL-6 was measured in 1,991 patients at
Background: There are few studies which compare the efficacy and safety of the Resolute Onyx zotarolimus-eluting stent (O-ZES) and everolimus-eluting stent (EES) in patients with acute myocardial infarction (AMI). Therefore, the present study aimed to compare clinical outcomes of O-ZES and EES in patients with AMI undergoing successful percutaneous coronary intervention (PCI). Methods: From January 2016 to December 2016, the Korea Acute Myocardial Infarction Registry (KAMIR) enrolled 3,364 consecutive patients. Among them, O-ZES was used in 402 patients and EES was used in 1,084 patients. The primary endpoint was target lesion failure (TLF), as defined by composite of cardiac death, target vessel myocardial infarction (TV-MI), and ischemic driven-target lesion revascularization (ID-TLR) at 6 month clinical follow-up. Results: At 6 months, the incidence of TLF was not significantly different between O-ZES and EES group (4.0% vs. 3.9%, adjusted hazard ratio [HR] 1.17, 95% confidential interval ...
OBJECTIVES: Compare gender disparities in ST-elevation myocardial infarction (STEMI) regarding first medical contact (FMC) and prehospital delay times and explore factors associated with prehospital delay in men and women separately.. DESIGN: Cross-sectional study based on medical records and a validated questionnaire. Eligible patients were enrolled within 24 hours after admittance to hospital.. SETTING: Patients were included from November 2012 to January 2014 from five Swedish hospitals with catheterisation facilities 24/7.. PARTICIPANTS: 340 men and 109 women aged between 31 and 95 years completed the survey.. MAIN OUTCOME MEASURES: FMC were divided into five possible contacts: primary healthcare centre by phone or directly, national advisory nurse by phone, emergency medical services (EMS) and emergency room directly. Two parts of prehospital delay times were studied: time from symptom onset to FMC and time from symptom onset to diagnostic ECG.. RESULTS: Women more often called an advisory ...
BACKGROUND/AIM: Acute myocardial infarction (AMI) is associated with increased coagulation which in the presence of unstable atheroma or endothelial damage leads to occlusive coronary vessel thrombosis. AMI is usually characterized by increased levels of catecholamines. It is possible there may be a link between catecholamines and hypercoagulation, but this still remains to be determined. In the current study we sought to verify whether hypercoagulation is associated with hypersympathetic activity in AMI patients, and whether there is a correlation between increased Methoxyhydroxyphenylglycol (MOPEG) levels (a metabolite of catecholamines) and shorter APTT (a marker of hypercoagulation). RESULTS: Shorter APTT values were detected in the plasma of AMI patients, which had also increased MOPEG levels. A linear correlation between APTT and MOPEG values was observed. High levels of the coagulation marker prothrombin (fragments 1+2) were also found. CONCLUSION: Shortened APTT demonstrates ...
TY - JOUR. T1 - Characteristics and prognosis of patients with suspected acute myocardial infarction and elevated MB relative index but normal total creatine kinase. AU - Lloyd-Jones, Donald M.. AU - Camargo, Carlos A.. AU - Giugliano, Robert P.. AU - Walsh, Craig R.. AU - ODonnell, Christopher J.. PY - 1999/11/1. Y1 - 1999/11/1. N2 - MB Leak patients who develop an elevated MB relative index with a normal total creatine kinase (CK) level are not as well characterized as those who have diagnostic enzyme elevations in the setting of ST elevation (↑) or non-ST↑ acute myocardial infarction (AMI). During a 1-year period, we studied all patients hospitalized in an urban academic hospital with suspected AMI who developed an elevated MB relative index within 24 hours of presentation. Of 595 patients, 44% had MB Leak, 34% had non-ST↑ AMI and 22% had ST↑ AMI. Patients with MB Leak and non-ST↑ AMI were significantly older than those with ST↑ AMI (mean ages 69, 71, and 63 years, ...
TY - JOUR. T1 - Joint effect of physical activity and body mass index on mortality for acute myocardial infarction in the elderly. T2 - Role of preinfarction angina as equivalent of ischemic preconditioning. AU - Abete, Pasquale. AU - Cacciatore, Francesco. AU - Della Morte, David. AU - Mazzella, Francesca. AU - Testa, Gianluca. AU - Galizia, Gianluigi. AU - De Santis, Domenico. AU - Longobardi, Giancarlo. AU - Ferrara, Nicola. AU - Rengo, Franco. PY - 2009/2/1. Y1 - 2009/2/1. N2 - BACKGROUND: Preinfarction angina (PrA), clinical equivalent of ischemic preconditioning, confers protection against in-hospital mortality for acute myocardial infarction (AMI) in adult but not in elderly patients. This study aims to examine the interaction between physical activity and body mass index (BMI) in preserving the cardioprotective effect of PrA in elderly patients with AMI. DESIGN: Elderly patients (≥65 years old) with AMI admitted to Coronary Care Unit. METHODS: Elderly patients with AMI were ...
Comparison of drug-eluting stents versus bare-metal stents for treating ST-segment elevation myocardial infarction. JACC Cardiovasc Interv. 2008 Jun; 1(3):227-32 ...
Our population has high prevalence of smoking. According to the National Health and Morbidity Survey (NHMS) Malaysia, the prevalence of adult male smokers in Malaysian population is 46.5 %, highest among the Malays (55.9 %), lower education group and rural areas (Lim et al. 2013). Reports from other regions regarding the unexpected favourable outcome of smokers post myocardial infarction has dated back to the pre-thrombolytic era of STEMI (Kelly et al. 1985; Helmers 1973). There have been great debates in the literature on this controversial topic and it has oftenly been disputed mainly on the confounding age and pre-morbid differences which favour smokers than the non-smokers in general (Grines et al. 1995; Barbash et al. 1995; Zuhdi et al. 2013).. Nevertheless, the main pathogenesis of acute myocardial infarction in smokers has been reported to differ from those of non-smokers. There is documented increase in haematocrit and fribrinogen levels in smokers which predispose them more to ...
Acute Coronary Syndromes : Review in-depth clinical information, latest medical news, and guidelines about acute coronary syndrome, classified as either ST segment elevation myocardial infarction (STEMI myocardial infarction) or non-STEMI myocardial infarction (NSTE or non-ST myocardial infarction) as reflected on ECG. Read about the latest angina and STEMI treatment.
Myocardial infarction[edit]. Main article: Myocardial infarction. Myocardial infarction (MI) or heart attack, is caused by ... In ST-elevation myocardial infarction (STEMI), IRI contributes up to 50% of final infarct size despite timely primary ... "Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations". European ... Ischaemia/infarction: if an arterial thrombus cannot be lysed by the body and it does not embolise, and if the thrombus is ...
Myocardial infarction[edit]. Main article: Myocardial infarction. Myocardial infarction (MI) or heart attack, is caused by ... Ischaemia/infarction: if an arterial thrombus cannot be lysed by the body and it does not embolise, and if the thrombus is ... This restriction gives an insufficient supply of oxygen to the heart muscle which then results in tissue death,(infarction). A ... an infarction) in the area past the occlusion. Venous thrombosis can lead to pulmonary embolism when the migrated embolus ...
... myocardial infarction; unanticipated reactions to the medications used during the procedure; damage to the conduction system, ... Myocardial perfusion imaging. Cardiovascular MRI. Ventriculography Radionuclide ventriculography. Cardiac catheterization/ ...
Acute myocardial infarction. Sinus tachycardia can present in more than a third of the patients with AMI but this usually ... Sinus tachycardia accompanying a myocardial infarction may be indicative of cardiogenic shock. Sinus tachycardia is usually a ... Tachycardia in the presence of AMI can reduce coronary blood flow and increase myocardial oxygen demand, aggravating the ... Rapid rates, though they may be compensating for ischemia elsewhere, increase myocardial oxygen demand and reduce coronary ...
non-fatal myocardial infarction. , death. ). 1.29 (1.02-1.63). 1.32 (1.02-1.72). 1.18 (0.70-1.97). 30. 23. 6. 37. 30. 7 ...
Suspected myocardial infarction (heart attack) or chest pain *ST elevated myocardial infarction (STEMI)[9] ... Main article: Electrocardiography in myocardial infarction. Ischemia or non-ST elevation myocardial infarctions (non-STEMIs) ... ST elevation myocardial infarctions (STEMIs) have different characteristic ECG findings based on the amount of time elapsed ... It is usually isoelectric, but may be depressed or elevated with myocardial infarction or ischemia. ST depression can also be ...
Biyik, I.; Ergene, O. (January-February 2007). "Alcohol and acute myocardial infarction". J Int Med Res. 35 (1): 46-51. doi: ... blood pressure and vascular tone and is associated with embolic stroke and acute myocardial infarction. Due to these risks ... In individuals with an underlying cardiac disorder a binge on alcohol increases the risk of silent myocardial ischaemia as well ...
Diagram of a myocardial infarction *. A coronary angiogram that shows the LMCA, LAD, and LCX ...
Chung MJ, Brown DL (July 2018). "Diagnosis of acute myocardial infarction.". In Brown DL (ed.). Cardiac Intensive Care-E-Book. ... Myoglobin is typically released in the circulation as early as 1 h after myocardial infarction,... Myoglobin has poor clinical ... elevated myoglobin has low specificity for acute myocardial infarction (AMI) and thus CK-MB, cardiac troponin, ECG, and ... Myoglobin is not specific for myocardial necrosis, however, especially in the presence of skeletal muscle injury and renal ...
"Myocardial Infarction". (Retrieved 29 November 2006) Introduction to Antibodies - Enzyme-Linked Immunosorbent Assay (ELISA). ( ...
Some patients, especially elderly and diabetics, may present with what is known as a painless myocardial infarction or a " ... Retrieved November 22, 2006 Davis TM, Fortun P, Mulder J, Davis WA, Bruce DG (2004). "Silent myocardial infarction and its ... Cervero F" Gut 2000; 47:56-57 Mallinson, T (2010). "Myocardial Infarction". Focus on First Aid (15): 15. Retrieved 2010-06-08. ... Myocardial ischemia, the most frequent cause of cardiac pain, is the most common cause of death in the United States. Urinary ...
Some of these conditions include: •Allergic reactions •Stroke •Sepsis •Myocardial infarction •Colitis, inflammation of the ...
"Myocardial infarction with ST-segment elevation: the acute management of myocardial infarction with ST-segment elevation [ ... "Regular aspirin intake and acute myocardial infarction". British Medical Journal. 1 (5905): 440-3. March 1974. doi:10.1136/bmj. ... Aspirin is an important part of the treatment of those who have had a myocardial infarction (heart attack).[38] ... aspirin has been thought to decrease the risk of a non-fatal myocardial infarction but not to change the overall risk of death. ...
"Acute myocardial infarction: Role of beta blocker therapy". Retrieved August 10, 2019.. ... Agents with ISA are not used after myocardial infarctions, as they have not been demonstrated to be beneficial. They may also ... Agents specifically labeled for myocardial infarction[72] *Atenolol, metoprolol (immediate release), propranolol (immediate ... myocardial infarction) after a first heart attack (secondary prevention).[1] They are also widely used to treat high blood ...
A myocardial infarction carries a greater than five-fold increase in relative risk for developing heart failure. If coronary ... This is known as myocardial infarction. A heart attack can cause arrhythmias, as well as permanent damage to the heart muscle. ... Lack of oxygen may also result in a myocardial infarction (heart attack). CAD can be contracted over time. Risk factors include ... Reed, Grant W.; Rossi, Jeffrey E.; Cannon, Christopher P. (14 January 2017). "Acute myocardial infarction". Lancet. 389 (10065 ...
The symptoms tend to occur 2-3 weeks after myocardial infarction but can also be delayed a few months. It tends to subside in a ... Dressler W (January 1959). "The post-myocardial-infarction syndrome: a report on forty-four cases". Arch Intern Med. 103 (1): ... Dressler syndrome was historically a phenomenon complicating about 7% of myocardial infarctions, but in the era of percutaneous ... Jaffe, AS; Boyle, AJ (2009). "Acute Myocardial Infarction". In Crawford, Michael H. (ed.). CURRENT Diagnosis & Treatment: ...
Unstable cardiovascular status (angina, recent myocardial infarction, etc.). *Thoracic, abdominal, or cerebral aneurysms ...
MRL mice are not protected against myocardial infarction; heart regeneration in adult mammals (neocardiogenesis) is limited, ... "Evidence that human cardiac myocytes divide after myocardial infarction". The New England Journal of Medicine. 344 (23): 1750-7 ... and at a higher rate in adults following acute heart injury such as infarction.[95] Even in adult myocardium following ... infarction, proliferation is only found in around 1% of myocytes around the area of injury, which is not enough to restore ...
Its Joint Commission certifications include Acute Myocardial Infarction; Joint Replacement - Hip; and Joint Replacement - Knee ...
"Early menopause and the risk of myocardial infarction". Am. J. Obstet. Gynecol. 139 (1): 47-51. PMID 7457520.. ...
Myocardial infarction heart attack. The words mean heart muscle blockage. Myo-inositol A substance in the cell that is thought ... Broken pieces of those deposits or closure of the arterial opening can cause myocardial infarction or stroke. Precisely what ...
Myocardial infarction in Nigerians. Tropical and geographical medicine. 1973;25(2):147-50. Falase AO, Oladapo OO, Kanu EO. ... Relatively low incidence of myocardial infarction in Nigerians. Cardiologie tropicale. 2001;27(107):45-7. Ogah OS, Adebayo O, ... Cardiomyopathies and myocardial disorders in Africa: present status and the way forward. Cardiovascular journal of Africa. 2012 ...
Myocardial infarction and stroke. Neurology. 1984 Nov;34(11):1403-9. PMID 6493488 Komrad MS. A defence of medical paternalism: ...
Solomon DH, Glynn RJ, Levin R, Avorn J (May 2002). "Nonsteroidal anti-inflammatory drug use and acute myocardial infarction". ... The plaintiff experienced a mild myocardial infarction and claimed that rofecoxib was responsible, after having taken it for ... previous myocardial infarction, angina, cerebrovascular accident, transient ischemic attack, or coronary artery bypass). ... patients on Vioxx were observed to have a four to five fold increase in myocardial infarctions (MIs) compared to patients on ...
Interferon-alpha can cause arrhythmia and myocardial infarction/ischemia. Mortality in HIV-infected patients with ... Myocardial toxoplasmosis causes an increase in the myocardial fraction of creatine kinase (CK-MB). In situ hybridization or ... Circ Res 1994;74:344-8. Barbaro, Incidence of Dilated Cardiomyopathy and Detection of HIV in Myocardial Cells of HIV- ... Furthermore, impaired myocardial growth and left ventricular dysfunction may be immunologically mediated as monthly intravenous ...
The heart's muscle cells may die from lack of oxygen and this is called a myocardial infarction (commonly referred to as a ... A region on chromosome 17 was confined to families with multiple cases of myocardial infarction.[117] Other genome-wide studies ... Unstable angina may precede myocardial infarction. In adults who go to the emergency department with an unclear cause of pain, ... In those with no previous history of heart disease, aspirin decreases the risk of a myocardial infarction but does not change ...
Strik JJ, Honig A, Maes M (May 2001). "Depression and myocardial infarction: relationship between heart and mind". Progress in ...
Beattie WS, Badner NH, Choi P (2001). "Epidural analgesia reduces postoperative myocardial infarction: a meta-analysis". Anesth ... The incidence of postoperative myocardial infarction ("heart attack") is reduced.[31][32] ...
Goldberger AL (1991). Myocardial Infarction: Electrocardiographic Differential Diagnosis (4th ed.). St. Louis: Mosby-Year Book ... CS1 maint: discouraged parameter (link) Henning, Robert J. (1976). "Myocardial Infarction: Electrocardiographic Differential ...
The patient population consisted of those with congestive heart failure or acute myocardial infarction. We found no significant ...
The most common severe adverse reactions were pulmonary edema/deep vein thrombosis, splenic rupture, and myocardial infarction ...
... people with acute myocardial infarction, and people with thyrotoxicosis of any etiology.[15] Levothyroxine is also ... Since thyroid hormone increases myocardial oxygen demand by increasing heart rate and contractility, starting at higher doses ...
However, other studies came to the conclusion that smoking bans have little or no short-term effect on myocardial infarction ... "The effects of smoke-free legislation on acute myocardial infarction: a systematic review and meta-analysis". BMC Public Health ... myocardial infarction] risk", but noted that "studies with smaller population in the United States usually reported larger ... have also analyzed smaller studies using subsamples and revealed that large short-term increases in myocardial infarction ...
The impact of late career job loss on myocardial infarction and stroke: A 10 year follow up using the health and retirement ... Is the effect of job strain on myocardial infarction risk due to interaction between high psychological demands and low ...
Ang ibang mga nagdudulot ng mga sintomas ay dapat isaalang-alang tulad ng isang myocardial infarction (atake sa puso) o isang ...
increased risk of myocardial infarction (heart attack)[7]:10[26]. *psychosis in extreme cases in the genetically predisposed[2] ...
A heart attack is also called a myocardial infarction. Myocardial means relating to the heart muscle. Infarction means death of ... So a myocardial infarction or heart attack is when blood flow to part of the heart stops. Then that part of the heart dies. ... Since they are more likely to get a myocardial infarction (heart attack) or stroke, they must watch for signs of these. ... If the organ or tissue dies, doctors call this an infarction. If it is hurt from low blood flow, but not enough to die, it is ...
... and thrombophlebitis and myocardial infarction.[37] Savinkova et al. has written a simulation to predict the KD value for a ... regulatory region of the tissue factor gene and the risk of myocardial infarction and venous thromboembolism: the ECTIM and ...
After commenting, "How beautiful it all is," he collapsed from a massive painful heart attack (myocardial infarction) and died ...
This disease process leads to myocardial infarction (heart attack), stroke and peripheral vascular disease. Since higher blood ...
DIC and efficacy of treatment in acute myocardial infarction. Alternatively, a more rapid detection of fibrinolytic activity, ...
Cerebral infarction - A "stroke", caused by complete oxygen deprivation due to an interference in cerebral blood flow which ... Hyperbaric oxygen therapy is being evaluated with the reduction in total and myocardial creatine phosphokinase levels showing a ... Pressman B. D.; Tourje E. J.; Thompson J. R. (Sep 1987). "An early CT sign of ischemic infarction: increased density in a ... without acute infarction. The symptoms of a TIA can resolve within a few minutes, unlike a stroke. TIAs share the same ...
Deaths from myocardial infarction. *Disease-related deaths in Quebec. *People from New Brunswick ...
A 2013 meta-analysis found no evidence that vitamin C supplementation reduces the risk of myocardial infarction, stroke, ...
... "myocardial infarction"[MeSH Terms] OR ("myocardial"[All Fields] AND "infarction"[All Fields]) OR "myocardial infarction"[All ... "myocardial infarction", "breast cancer" to "breast neoplasms". Where appropriate, these MeSH terms are automatically "expanded ...
Myocardial infarction. *Unstable angina. Sequelae. *hours *Hibernating myocardium. *Myocardial stunning. *days *Myocardial ...
... used to reveal the presence of a blood clot in the coronary arteries of patients with unstable angina and myocardial infarction ...
Temporay pacing may be done for very slow heartbeats, or bradycardia, from drug overdose or myocardial infarction. A pacemaker ...
Deaths from myocardial infarction. *English movie actors. *English painters. *English stage actors ...
... reduced frequency of the Pro715 allele carriers in patients with myocardial infarction". Hum. Mol. Genet. 7 (8): 1277-84. doi: ...
2004). "Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART ...
Ischemia in the heart due to prolonged coronary vasospasm can lead to angina, myocardial infarction and even death. ...
Deaths from myocardial infarction. *Politicians from New York City. *US Democratic Party politicians ...
Though uncommon, potentially fatal adverse effects include stroke, myocardial infarction, GI bleeding, Stevens-Johnson syndrome ... myocardial infarction, stroke, heart failure, coagulation disorders, renal impairment, and hepatic impairment.[8][9] ...
Cardiac conditions such as congestive heart failure and after myocardial infarction 3) Preservation of kidney function in ...
Deaths from myocardial infarction‎ (1,274 P). Pages in category "Heart disease". The following 14 pages are in this category, ...
Cardiovascular system damage can include myocardial ischemia/infarction, acute left ventricular dysfunction, acute pulmonary ... and myocardial infarction.[10] Single-organ involvement is found in approximately 83% of hypertensive emergency patients, two- ... The most common clinical presentations of hypertensive emergencies are cerebral infarction (24.5%), pulmonary edema (22.5%), ... Excessive reduction in blood pressure can precipitate coronary, cerebral, or renal ischemia and, possibly, infarction. ...
... but may also occur following a myocardial infarction. Pericarditis is usually a short-lived condition that can be successfully ...
myocardial infarction (*MI*) (my-oh-*kar*-di-ăl) n.* death of a segment of heart muscle, which follows interruption of its ... Myocardial Infarction. Definition. A myocardial infarction, or heart attack, is the death or damage of part of the heart muscle ... Myocardial infarctions are commonly called heart attacks.. A myocardial infarction occurs when one or more of the coronary ... Myocardial infarctions are generally caused by severe coronary artery disease. Most myocardial infarctions are caused by blood ...
Acute myocardial infarction has high mortality, but early medical and surgical intervention can be lifesaving.1 2 3 4 5 6 ... The authors evaluated the literature on acute myocardial infarction and off-hour care. Outcomes included in-hospital and 30 day ... as well as door to balloon time for the subset of patients with ST elevation myocardial infarction. Using a random effects ... patients presenting to hospital with an acute myocardial infarction during off-hours (evenings and weekends) wait longer for ...
Anticoagulants in Myocardial Infarction. Br Med J 1953; 1 doi: (Published 16 May 1953 ...
Myocardial infarction: A syndrome of prolonged, severe chest pain was first described in medical literature in 1912 by James ... Both the immediate and the long-term outlook of persons after myocardial infarction depends on the extent of myocardial damage ... infarction). The term myocardial infarction, therefore, is more appropriate. The less specific term heart attack may be more ... acute myocardial infarction does not always occur. In most persons who have died almost instantaneously, no infarction was ...
Coronary Artery Disease: Beta Blocker Therapy - Prior Myocardial Infarction or Left Ventricular Systolic Dysfunction (LVEF ,40 ... 1 of the year prior to the measurement year to June 30 of the measurement year with a diagnosis of acute myocardial infarction ... and older with a diagnosis of coronary artery disease seen within a 12 month period who also have a prior myocardial infarction ... patients evaluated in an outpatient setting who within the previous 12 months have experienced an acute myocardial infarction ( ...
Myocardial infarction (MI) and the resulting loss of functionality of the myocardium appear to be the major causes for the ... Sexbased differences in early mortality after myocardial infarction. National registry of myocardial infarction 2 participants ... Stem cell mobilization by granulocyte colony-stimulating factor for myocardial recovery after acute myocardial infarction: a ... Papageorgiou N., Tousoulis D. (2019) Healing of Myocardial Infarction. In: Cokkinos D. (eds) Myocardial Preservation. Springer ...
Their occurrence often indicates myocardial dysfunction and they may, by themselves, cause congestive heart failure or exac ... Supraventricular arrhythmias after myocardial infarction. Authors. David Spragg, MD, FHRS. David Spragg, MD, FHRS ... Myocardial infarction and atrial arrhythmias. Circulation 1961; 24:761.. *Wong CK, White HD, Wilcox RG, et al. New atrial ... Bradyarrhythmias in acute myocardial infarction. Circulation 1972; 45:703.. *Zimetbaum PJ, Josephson ME. Use of the ...
A review of data from The National Registry of Myocardial Infarction. ...
Cite this: Shingles Increases Risk for Stroke and Myocardial Infarction - Medscape - Dec 17, 2015. ... temporarily increases the risk for stroke and potentially myocardial infarction (MI) in the months after the infection, ...
In this chapter, we will focus on complications of acute myocardial... ... Acute myocardial infarction. N Engl J Med. 2017;376:2053-64.CrossRefPubMedGoogle Scholar ... Defibrillator implantation early after myocardial infarction. N Engl J Med. 2009;361:1427-36.CrossRefPubMedGoogle Scholar ... Ventricular free wall rupture following acute myocardial infarction. Coron Artery Dis. 2003;14:463-70.CrossRefPubMedGoogle ...
In order to recognize abnormalities that suggest ischemia or infarction, it is imp ... is an important test used in the clinical evaluation of patients with suspected or known myocardial ischemia or myocardial ... ECG tutorial: Myocardial ischemia and infarction. Author. Jordan M Prutkin, MD, MHS, FHRS. Jordan M Prutkin, MD, MHS, FHRS ... Value of leads V7-V9 in diagnosing posterior wall acute myocardial infarction and other causes of tall R waves in V1-V2. Am J ...
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Latest Research : Cardiology : Myocardial Infarction PlGF involved in Post Myocardial Infarction Healing Process. Heart attack ... Latest Research : Cardiology : Myocardial Infarction Ambient air pollution linked with acute myocardial infarction. Scientists ... Latest Research : Cardiology : Myocardial Infarction Drug-Eluting Stents Effective in Acute Myocardial Infarction: STRATEGY ... Latest Research : Cardiology : Myocardial Infarction Hot cup of cocoa or red wine?. Cocoa shows benefits for coronary heart ...
... for acute myocardial infarction. N Engl J Med. 1996;335: 685-91. Management of acute myocardial infarction in patients ... Primary Angioplasty for Acute Myocardial Infarction. J Am Coll Myocardial Infarction Regionalization Strategies. Circ ... acute myocardial infarction; PPCI: primary angioplasty; PHT: pre-hospital thrombolysis; STEMI: ST-elevation myocardial ... acute ST-segment elevation myocardial infarction - Results of the Primary PTCA versus thrombolysis with tPA in acute myocardial ...
MYOCARDIAL INFARCTION, EXPERIMENTAL CARDIAC NECROSES, AND POTASSIUM PLINIO PRIORESCHI* I. Myocardial Infarction It has been ... Myocardial Infarction Perspectives in Biology and Medicine · Spring 19 ful in the treatment of angina pectoris [18-20]. Rowe ... The problem of human myocardial infarction passed through stage 2 when everybody was happy with the explanation that the ... The almost invariable association ofcoronary atherosclerosis and acute myocardial infarction is not questioned. Troubles begin ...
Transcript of Myocardial Infarction 62. ECG. bpm. Thank You!. What is a heart attack? blood flow that brings oxygen to the ... Myocardial Infarction Uncomfortable pressure, squeezing, fullness or pain in the center of your chest. It lasts more than a few ... The EMT performed the standard protocol for a patient with symptoms of a myocardial infarction. Doctors, please tell me what ...
INTRODUCTION Chest pain is the most usual symptom at presentation in patients with acute myocardial infarction (AMI), even if ... Myocardial Infarction Case Study. 1906 Words , 8 Pages. · Thrombosis and embolic: central nervous system or peripheral ... More about Myocardial Infarction: A Case Study. *. Pulmonary Oedema Case Study. 981 Words , 4 Pages ... INTRODUCTION Chest pain is the most usual symptom at presentation in patients with acute myocardial infarction (AMI), even if ...
... such as myocardial infarction [5-9]. However, these data do not cover the full range of variability of myocardial infarction ... Myocardial infarction is one of the clinical manifestations of coronary heart disease. In some cases, the cause of myocardial ... Myocardial infarction is one of the clinical manifestations of coronary heart disease. In this serious disease, some myocardial ... Mitochondrial Genome Mutations Associated with Myocardial Infarction. Margarita A. Sazonova,1,2 Anastasia I. Ryzhkova,1 Vasily ...
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Acute Myocardial Infarction. Myocardial infarction occurs when myocardial ischemia exceeds a critical threshold and overwhelms ... eMedicine - Myocardial Infarction : Article by Drew E Fenton. Myocardial infarction (MI) is the rapid development of myocardial ... Inferior Myocardial Infarction (Site not responding. Last check: ). Myocardial infarctions occur when the blood supply to a ... Heart Attack , Myocardial Infarction. A heart attack or myocardial infarction is a medical emergency in which the supply of ...
Myocardial scans with sup(99m)Tc-labelled phosphates are reported to be useful in the diagnosis of acute myocardial infarction ... title = {Scan analysis in myocardial infarction}. author = {Ell, P J}. abstractNote = {Myocardial scans with sup(99m)Tc- ... Ell, P J. Scan analysis in myocardial infarction. Germany: N. p., 1976. Web. ... 62 RADIOLOGY AND NUCLEAR MEDICINE; MYOCARDIAL INFARCTION; DIAGNOSIS; MYOCARDIUM; SCINTISCANNING; HEART; ISOMERIC NUCLEI; ...
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Myocardial Infarction) Clinical Research Trial Listings in Cardiology/Vascular Diseases Trauma (Emergency, Injury, Surgery) ... Heart Attack (Myocardial Infarction) Clinical Trials. A listing of Heart Attack (Myocardial Infarction) medical research trials ... Aerobic fitness is related to long-term survival and a reduction in mortality and recurrent nonfatal myocardial infarction in ... Atherosclerosis is the most common cause of myocardial infarction, stroke and peripheral arterial disease. Research has clearly ...
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What Are The Signs Of A Myocardial Infarction_, Author: Jennifer Lewis, Name: What Are The Signs Of A Myocardial Infarction_, ... What Are The Signs Of A Myocardial Infarction? Significant heart problems may be the principal indicator. The anguish might ...
  • Outcomes included in-hospital and 30 day mortality, as well as door to balloon time for the subset of patients with ST elevation myocardial infarction. (
  • ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction. (
  • Mechanical complications after percutaneous coronary intervention in ST-elevation myocardial infarction (from APEX-AMI). (
  • 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice guidelines: developed in collaboration with the American College of Emergency Physicians and Society for Cardiovascular Angiography and Interventions. (
  • EMBASE (1966 to 2011) and NHS Non-STEMI non-ST-elevation myocardial infarction EED (1997 to 2011) in order to identify economic evaluation stud- PPCI primary angioplasty ies that had used PCI vs. TL for the treatment of AMI. (
  • Acute Coronary Syndrome is a name given to three types of coronary artery disease that are associated with sudden rupture of plaque inside the coronary artery: unstable angina, Non-ST segment elevation myocardial infarction or heart attack (NSTEMI), or ST segment elevation myocardial infarction or heart attack (STEMI). (
  • Early use of mineralocorticoid receptor antagonists in ST-elevation myocardial infarction: is it ever too early? (
  • Reperfusion Therapy for Acute Myocardial Infarction provides a comprehensive review of reperfusion therapy for ST-segment elevation myocardial infarction (STEMI). (
  • The association between implanted stent types and heart failure in patients with non -ST-elevation myocardial infarction (NSTEMI) remains unknown. (
  • In Paul Armstrong's review article on fibrinolytic therapy for acute ST-segment elevation myocardial infarction, the fibrinolytic or thrombolytic treatment recommended for the case presented is not completely supported by the evidence cited. (
  • The clock should start at the time of ST-segment elevation myocardial infarction (STEMI) diagnosis by electrocardiogram (ECG). (
  • When the ST segment peaks, the change is known as the ST-segment elevation myocardial infarction, or STEMI, notes the American Heart Association. (
  • Background: Percutaneous coronary intervention (PCI) is a highly effective therapy for acute ST-elevation myocardial infarction (STEMI). (
  • In patients with acute ST-segment elevation myocardial infarction (STEMI), percutaneous coronary intervention (PCI) may cause thrombus dislodgment and impaired microcirculatory reperfusion. (
  • International guidelines recommend primary percutaneous coronary intervention (pPCI) as the first-line treatment for patients with ST-elevation myocardial infarction (STEMI) if it can be performed within 90 minutes of first medical contact or 2 hours after symptom onset by an experienced team. (
  • Furthermore registries are demonstrating the real world benefits from the strategy including the French registry on Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI) 3,6 and a structured STEMI network in Sao Paulo, Brazil. (
  • Five-year survival in patients with ST-segment elevation myocardial infarction according to modalities of reperfusion therapy: the French Registry on Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) 2005 cohort. (
  • Fibrinolysis or Primary PCI in ST-Segment Elevation Myocardial Infarction. (
  • ST-Elevation myocardial infarction network: systematization in 205 cases reduced clinical events in the public health care system. (
  • Although witnessing an ongoing asymptomatic ST elevation myocardial infarction (STEMI) is rare, this case highlights the importance of early revascularization when the ECG demonstrates a STEMI, even in the absence of symptoms for patients at risk for silent myocardial infarctions. (
  • ST-Segment Elevation Myocardial Infarction is a topic covered in the Washington Manual of Medical Therapeutics . (
  • Washington Manual , (
  • People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use of PCI in those at high risk. (
  • When there is evidence of an MI, it may be classified as an ST elevation myocardial infarction (STEMI) or Non-ST elevation myocardial infarction (NSTEMI) based on the results of an ECG. (
  • A chapter has been added on myocardial infarction with non-obstructive coronary arteries (MINOCA), which comprises up to 14% of STEMI patients and demands additional diagnostic tests and tailored therapy which may differ from typical STEMI. (
  • Patients who survive STEMI often go on to develop infarct expansion and myocardial thinning which can lead to heart failure and, ultimately, death. (
  • Recent clinical studies have shown that systemic therapeutic hypothermia improving the outcomes in patients with ST segment elevated myocardial infarction (STEMI) received primary percutan. (
  • 3 Results from the Strategic Reperfusion Early After Myocardial Infarction (STREAM) trial indicate that a pharmaco-invasive strategy for STEMI care is feasible for patients who cannot receive primary PCI within the recommended time window. (
  • STEMI is defined as a clinical syndrome of myocardial ischemia in association with persistent ECG ST elevations (see " Diagnostic Testing " section). (
  • Wolfe CL, Nibley C, Bhandari A, Chatterjee K, Scheinman M. Polymorphous ventricular tachycardia associated with acute myocardial infarction. (
  • Myocardial infarction is characterized by cellular death ( necrosis ) of a segment of the heart muscle. (
  • The problem of human myocardial infarction passed through stage 2 when everybody was happy with the explanation that the syndrome was produced by a sudden occlusion ofa branch ofa coronary artery with subsequent acute ischemia and necrosis ofthe area supplied by the occluded vessel. (
  • Myocardial necrosis (i.e.MI) is said to be present if the maximal concentration of cTnT or cTnI exceeds the decision limit (99 percent of the values for a reference control group) on at least one occasion during the 24 hours after the index clinical event. (
  • Myocardial infarction (MI) is the rapid development of myocardial necrosis caused by a critical imbalance between oxygen supply and demand of the myocardium . (
  • The appearance of cardiac markers in the circulation generally indicates myocardial necrosis and is a useful adjunct to diagnosis. (
  • For early detection of myocardial necrosis , sensitivity of this laboratory test is superior to that of the creatine kinase-MB (CK-MB). (
  • Acute myocardial infarction (MI) generally refers to segmental (regional) myocardial necrosis, typically endocardium-based, secondary to occlusion of an epicardial artery. (
  • Inflammatory markers such as C-reactive protein (CRP) reflect the extent of myocardial necrosis and correlate with cardiac outcomes following AMI ( 2 - 4 ). (
  • The pathophysiological mechanism of MC post AMI is complete lack of perfusion leading to myocardial necrosis, neutrophil infiltration, activation of matrix metalloproteinases (MMPS) and degradation of collagen struts by serine protease leading to slippage of myocytes, wall thinning, increased wall stress and ventricular dilatation, and finally wall disruption and rupture. (
  • Myocardial infraction, commonly known as heart attack is an acute irreversible medical condition that leads to necrosis of the heart muscles. (
  • When a severe enough plaque rupture occurs in the coronary vasculature, it leads to myocardial infarction (necrosis of downstream myocardium). (
  • Myocardial infarction is the irreversible necrosis of heart muscle secondary to prolonged ischemia. (
  • 1 A myocardial infarction (MI), defined as clinical evidence of myocardial necrosis consistent with myocardial ischemia, is diagnosed every 34 seconds in the United States. (
  • Necrosis begins after 20 minutes of an infarction. (
  • Acute myocardial infarction has high mortality, but early medical and surgical intervention can be lifesaving. (
  • 5 7 8 In most of these studies, patients presenting to hospital with an acute myocardial infarction during off-hours (evenings and weekends) wait longer for interventional treatments than those presenting during regular office hours and have a higher mortality. (
  • Mortality benefits from implantable cardioverter-defibrillator therapy are not restricted to patients with remote myocardial infarction: an analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). (
  • Thus, the decline in mortality can be envisioned as reflecting an improvement in survival, which may be mediated by a declining severity of myocardial infarction. (
  • Hence, these findings demonstrated a consistent improvement across all severity indicators, thereby suggesting that the declining severity of myocardial infarction contributed to the decline in coronary disease mortality. (
  • Aerobic fitness is related to long-term survival and a reduction in mortality and recurrent nonfatal myocardial infarction in subjects with cardiovascular disease. (
  • The outcomes we investigated were all-cause mortality within 30 days of discharge from hospital, and death from acute myocardial infarction at any time during the study period. (
  • The Aspirin Myocardial Infarction Study was conducted to determine whether the daily administration of at least one gram of aspirin to persons who had at least one documented myocardial infarction would result in a significant reduction in total mortality over a three year period. (
  • To determine if the diagnosis of major depression in patients hospitalized following myocardial infarction (MI) would have an independent impact on cardiac mortality over the first 6 months after discharge. (
  • Authors: Sabet Sarvestani F, Azarpira N Abstract Heart and cerebral infarctions, as two important ischemic diseases, lead to the death of tissues due to inadequate blood supply and high mortality worldwide. (
  • Myocardial infarction (MI) is a serious health problem which causes substantial morbidity and mortality. (
  • OBJECTIVE -Stress hyperglycemia has been associated with increased mortality in patients with myocardial infarction (MI). (
  • Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. (
  • Despite a strong association between elevated blood glucose levels and increased rates of mortality among patients hospitalised with acute myocardial infarction (AMI), the benefit of acutely lowering levels of blood glucose remains controversial. (
  • In aging societies, atherosclerosis (AS) and its major vascular complications, myocardial infarction and stroke, comprise a leading cause of morbidity and mortality. (
  • Previous studies have found that the socioeconomic risk factors education, income and family type were independently associated with mortality after first myocardial infarction (MI). (
  • Although beta-adrenergic blockers can significantly reduce mortality after a myocardial infarction, these agents are prescribed to only a minority of patients. (
  • Beta blockers reduce mortality during both acute and long-term management of myocardial infarction. (
  • Administration of intravenous beta blockers within 12 to 24 hours of infarction, followed by oral therapy, has been found to reduce the mortality rate approximately 13 percent within the first week of infarction. (
  • Initiation of beta-blocker therapy within days to weeks after infarction and continuation of therapy for periods ranging from several months to three years was found in randomized trials to reduce total mortality, nonfatal myocardial infarction and sudden death by approximately 20 to 30 percent. (
  • Because nonadherence to medications is common in patients after a myocardial infarction and is associated with increased mortality risk, modifiable factors associated with medication self-discontinuation should be addressed before discharge. (
  • Myocardial infarction (MI) and the resulting loss of functionality of the myocardium appear to be the major causes for the failing heart. (
  • Diabetic and elderly subjects are those who generally present with a lower severity of chest pain and at the same time represent the subgroups of AMI patients withworse outcome.3 Chest pain characteristics over time may also change in relation to the presence and severity of myocardial ischemia whichdepends on several factors influencing the relationship between myocardium at risk oxygen supply and demand. (
  • As the duration of the occlusion increases, the area of myocardial cell death enlarges, extending from the endocardium to the myocardium and ultimately to the epicardium . (
  • Therefore, in cases of thromboemboli from epicardial thrombi (especially plaque erosions), there may be patchy infarction, often associated with visible thrombi within the myocardial vessels, not centered in the endocardium but occurring anywhere in the myocardium, including midepicardial and subepicardial locations. (
  • Acute myocardial infarction (MI) results from lack of oxygen supply to the working myocardium. (
  • Transverse and horizontal sections of the myocardium are mounted to show the appearances of acute myocardial infarction. (
  • microRNAs Alterations of Myocardium and Brain Ischemia-Reperfusion Injury: Insight to Improve Infarction. (
  • The resulting ischemia (restriction in blood supply) and oxygen shortage, if left untreated for a sufficient period of time, can cause damage and / or death ( infarction ) of heart muscle tissue ( myocardium ). (
  • Protective effects of percutaneous transluminal coronary recanalization (PTCR) on the myocardium were investigated by creatine phosphokinase levels, regional left ventricular wall motion in chronic stage and /sup 201/Tl myocardial single photon emission computed tomography. (
  • Recanalization of the occlusive coronary artery at the early stage of myocardial infarction was effective for the protection of the myocardium and heart functions. (
  • misc{etde_6206638, title = {Effectiveness of selective intracoronary thrombolysis in acute myocardial infarction} author = {Yamaguchi, Hiroshi, Nosaka, Hideyuki, and Saitoh, Taroh} abstractNote = {Protective effects of percutaneous transluminal coronary recanalization (PTCR) on the myocardium were investigated by creatine phosphokinase levels, regional left ventricular wall motion in chronic stage and /sup 201/Tl myocardial single photon emission computed tomography. (
  • Myocardial infarction (MI) refers to tissue death (infarction) of the heart muscle (myocardium) caused by ischaemia, that is lack of oxygen delivery to myocardial tissue. (
  • The shear stress between the infarcted segment and the surrounding normal myocardium (which may be hypercontractile in the post-infarction period) makes it a nidus for rupture. (
  • That is why it is vitally important to teach patients to recognize the signs of a myocardial infarction and seek immediate medical attention at the nearest hospital with 24-hour emergency cardiac care. (
  • Smokers have two to four times the risk of non-smokers of sudden cardiac death and are more than twice as likely to have a myocardial infarction. (
  • Gaudron P, Kugler I, Hu K, Bauer W, Eilles C, Ertl G. Time course of cardiac structural, functional and electrical changes in asymptomatic patients after myocardial infarction: their inter-relation and prognostic impact. (
  • The cardiac fibroblast: therapeutic target in myocardial remodeling and failure. (
  • Long-term recording of cardiac arrhythmias with an implantable cardiac monitor in patients with reduced ejection fraction after acute myocardial infarction: the cardiac arrhythmias and risk stratification after acute myocardial infarction (CARISMA) study. (
  • They examined a large, multiracial population and relied on several indicators, including the composite Predicting Risk of Death in Cardiac Disease Tool (PREDICT) score to conclude that the severity of infarction declined over time. (
  • Cardiac troponin I in the diagnosis of myocardial injury and infarction . (
  • The High-STEACS trial is the first randomized trial to evaluate whether the introduction of a high-sensitivity cardiac troponin I assay with a 99th centile diagnostic threshold would reduce subsequent myocardial infarction or cardiovascular death at one year in patients with suspected acute coronary syndrome. (
  • Professor Mills said: 'The trial found that implementation of a high-sensitivity cardiac troponin I assay using the 99th centile as the diagnostic threshold increased the frequency of diagnosing myocardial injury or infarction. (
  • Learn more about myocardial infarction (heart attack) symptoms, treatment and prevention and discover what some of the main risk factors for cardiac arrest are, here. (
  • Both ECG changes and the raised activities of cardiac enzymes would corroborate a diagnosis of Myocardial infarction for Mr Smith. (
  • However, data from the 2012 Myocardial Infarction National Audit Project (MINAP) highlight that only 44% of all patients take part in cardiac rehabilitation after an MI. (
  • Here, we show that Angpt2 plays multifaceted roles in the exacerbation of cardiac hypoxia and inflammation after myocardial ischemia. (
  • The traditional diagnosis of myocardial infarction (MI) used the World Health Organization definition and required the concentration of a cardiac biomarker to be above twice the upper limit of normal. (
  • It is often considered a benign normal variant of coronary anatomy, but it has been rarely linked to myocardial ischemia, infarction, and sudden cardiac death. (
  • ACE2 deficiency impairs cardiac contractility and upregulates hypoxia-induced genes, suggesting a link with myocardial ischaemia. (
  • i.e., between 23 and 44 days), 2) reduce microvascular obstruction (MVO) by cardiac MRI at 5 + 2 days (i.e., between 3 and 7 days), 3) enhanced ST-segment resolution, 4) improved myocardial perfusion, 5) reduced thrombus burden and angiographic complications, and 6) no increase in major and minor bleeding. (
  • 1 Myocardial infarction (MI) refers to the ischaemia that occurs in an area of cardiac muscle when the blood supply to that area is blocked (by thrombus, atherosclerosis or embolism within the cardiac vessels). (
  • Unlike the other type of acute coronary syndrome, unstable angina, a myocardial infarction occurs when there is cell death, this can be estimated by measuring by a blood test for biomarkers (the cardiac protein troponin). (
  • Professor Nicholas Mills, principal investigator, University of Edinburgh, UK, said: 'These results are controversial because they suggest that the Universal Definition of Myocardial Infarction needs to move away from binary thresholds to diagnose and treat patients with myocardial infarction. (
  • The Universal Definition of Myocardial Infarction recommends that any increase in troponin above the 99th centile of a healthy reference population should be used as one of the diagnostic criteria. (
  • Dr Ibanez said: "We collaborated with other ESC Guideline Task Forces producing documents for this year and next, especially on dual antiplatelet therapy and the universal definition of myocardial infarction, to ensure consistency. (
  • Hochman JS, Choo H. Limitation of myocardial infarct expansion by reperfusion independent of myocardial salvage. (
  • The authors found in an ex vivo model of regional myocardial ischemia (30 minutes) followed by reperfusion with Krebs-Henseleit buffer (2.5 hours) that aldosterone or cortisol infusion could increase infarct size. (
  • however, a stress nuclear study showed a small myocardial infarct. (
  • So myocardial infarct, lack of of oxygen to heart muscle causing death of that heart muscle. (
  • Angpt2 was highly expressed in endothelial cells at the infarct border zone after myocardial infarction (MI) or ischemia/reperfusion injury in mice. (
  • After an infarction, an obvious complication is a second infarction, which may occur in the domain of another atherosclerotic coronary artery, or in the same zone if there are any live cells left in the infarct. (
  • A myocardial infarction occurs when one or more of the coronary arteries that supply blood to the heart are completely blocked and blood to the heart muscle is cut off. (
  • They suggested that "thrombosis occurs as a secondary manifestation" ofthe infarction. (
  • In most cases, acute myocardial infarction occurs due to coronary artery thrombosis in the area of an atherosclerotic plaque [ 1 , 2 ]. (
  • Myocardial infarction occurs when myocardial ischemia exceeds a critical threshold and overwhelms myocardial cellular repair mechanisms that are designed to maintain normal operating function and hemostasis. (
  • A Heart Attack (Myocardial Infarction) occurs when blood flow to a section of heart muscle becomes blocked. (
  • Acute MI may be either of the nonreperfusion type, in which case the obstruction to blood flow is permanent, or of the reperfusion type, in which the obstruction or lack of blood flow is long enough in duration (generally hours) but is reversed or restored after myocardial cell death occurs. (
  • When acute myocardial infarction occurs in patients with bacteremia, it usually results from hypotension or from endocarditis with septic emboli to the coronary arteries. (
  • If this clot becomes so large that it blocks the blood flow through the artery, acute myocardial infarction occurs. (
  • A heart attack (myocardial infarction) occurs when an area of heart muscle dies or is permanently damaged because of an inadequate supply of oxygen to that area. (
  • Myocardial infarction ( MI or AMI for acute myocardial infarction ), commonly known as a heart attack , occurs when the blood supply to part of the heart is interrupted causing some heart cells to die. (
  • 5 Studies indicate that the most marked reduction (25 percent) occurs in the first two days after infarction. (
  • A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle. (
  • The percentage of patients 18 years of age and older during the measurement year who were hospitalized and discharged from July 1 of the year prior to the measurement year to June 30 of the measurement year with a diagnosis of acute myocardial infarction (AMI) and who were prescribed persistent beta-blocker treatment for six months after discharge. (
  • The focus of further researches for the determination of the causes of myocardial infarction development should be transferred to the interaction of environmental, ecological, and molecular-genetic risk factors, as well as to the search of new methods and approaches to early diagnosis of individual predisposition. (
  • Myocardial scans with sup(99m)Tc-labelled phosphates are reported to be useful in the diagnosis of acute myocardial infarction. (
  • misc{etde_7240304, title = {Scan analysis in myocardial infarction} author = {Ell, P J} abstractNote = {Myocardial scans with sup(99m)Tc-labelled phosphates are reported to be useful in the diagnosis of acute myocardial infarction. (
  • Polymorphonuclear leukocytes showed intracytoplasmic rods, which were Gram-negative (Figure ⇓ , D). A presumptive diagnosis of Capnocytophaga canimorsus sepsis complicated by acute myocardial infarction was made on the basis of clinical presentation, ECG tracing, and laboratory results. (
  • Of those, less than one third had a final diagnosis of myocardial infarction. (
  • The reasons for this are due to the fact that the diagnosis of posterior myocardial infarctions is still considered to be the " dark side of the moon " of ECG interpretation. (
  • This case study examines the effects of the clinical diagnosis of myocardial infarction (MI) of a 58 year old employee, Mr Smith (pseudonym) and an assessment of his fitness to work. (
  • Correct interpretation of these patterns is extremely important as ECGs form the most important first-line tools in the diagnosis of myocardial infarction and ischemia, according to the American Heart Association. (
  • Patients with previous myocardial infarction (MI) and stroke are the highest risk group for further coronary and cerebral events. (
  • Population of adults aged 30-69, with documented evidence of previous myocardial infarction(s). (
  • The almost invariable association ofcoronary atherosclerosis and acute myocardial infarction is not questioned. (
  • In particular, myocardial infarction can occur in patients with atherosclerosis, arterial hypertension, and coronary heart disease. (
  • At the present time, there are no reliable algorithms for the early prognosis of myocardial infarction, which would determine an increased individual predisposition to this disease and its risk factor, atherosclerosis. (
  • In a number of published articles, there has been a report of mutations and polymorphisms of the nuclear genome associated with a risk factor for atherosclerosis, such as myocardial infarction [ 5 - 9 ]. (
  • Atherosclerosis is the most common cause of myocardial infarction, stroke and peripheral arterial disease. (
  • The main cause of myocardial infarction is atherosclerosis in the coronary arteries. (
  • Myocardial infarction is a common consequence of atherosclerosis and coronary artery disease. (
  • Myocardial infarction is commonly related to the gradual accumulation of cholesterol plaques in the arterial walls known as atherosclerosis . (
  • Transient exposure to coffee as a trigger of a first nonfatal myocardial infarction. (
  • The outstanding clinical feature of myocardial infarction is pain, similar in many respects to that of angina pectoris . (
  • The electrocardiogram (ECG) is an important test used in the clinical evaluation of patients with suspected or known myocardial ischemia or myocardial infarction (MI). (
  • Myocardial infarction is one of the clinical manifestations of coronary heart disease. (
  • Clinical endpoints for the study were documented fatal and non-fatal myocardial infarction. (
  • NICE, the American Heart Association (AHA), the American College of Cardiology (ACC) and The European Society of Cardiology (ESC) clinical guidelines recommend risk factor modification by optimisation of drug therapies for secondary prevention in patients who have suffered a myocardial infarction. (
  • However, the growth of the global market for myocardial infraction treatment is likely to be adversely affected by the high cost of clinical and hospital trials and strict regulations. (
  • We found that individuals operated on for their obesity were at a much lower risk of suffering another myocardial infarction, of death and of developing heart failure," says the study's first author Erik Naslund, professor at the Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet and consultant surgeon at Danderyd Hospital. (
  • Before the results of the study can become part of clinical praxis, more research is needed in which severely obese people who have suffered myocardial infarction are randomly assigned to either surgery or to regular post-infarction care. (
  • CLEVELAND, May 21 -- A meta-analysis of data from 42 clinical trials found a 43% increase in relative risk of myocardial infarction among type 2 diabetics treated with rosiglitazone (Avandia). (
  • What are the symptoms of acute myocardial infarction? (
  • Classical symptoms of acute myocardial infarction include sudden chest pain (typically radiating to the left arm or left side of the neck), shortness of breath, nausea, vomiting, palpitations, sweating, and anxiety (often described as a sense of impending doom). (
  • One systematic review of primary and secondary prevention trials has reported that statins constitute the single most effective type of treatment for reducing fatal and non fatal myocardial infarctions and cardiovascular deaths. (
  • Kutty RS, Jones N, Moorjani N. Mechanical complications of acute myocardial infarction. (
  • The first step in management is to exclude potentially correctable causes of cardiogenic shock , such as RV infarction (treated with fluid infusions) or mechanical complications which may require surgical repair. (
  • The main mechanical complications (MC) of acute myocardial infarction are ventricular septal rupture(VSR), free wall rupture(FWR), and ischemic mitral regurgitation (IMR). (
  • Myocardial infarction complications may occur immediately following a heart attack (in the acute phase), or may need time to develop (a chronic problem). (
  • Post-myocardial complications occur after a period of ischemia, these changes can be seen in gross tissue changes and microscopic changes. (
  • Survivors of MI are at increased risk of recurrent infarctions and have an annual death rate of 5% - six times that in people of the same age who do not have coronary heart disease. (
  • Recurrent infarction ( infarction in a different artery ) within 48 hours may occur in up to 40% of patients and can be difficult to diagnose. (
  • However, use of this method to help diagnose and treat patients was not associated with lower rates of recurrent myocardial infarction or cardiovascular death at one year. (
  • Optimal management of myocardial infarction in the subacute period focuses on improving the discharge planning process, implementing therapies early to prevent recurrent myocardial infarction, and avoiding hospital readmission. (
  • Pathophysiology of Myocardial Infarction, Prediman K. Shah, M.D. (
  • 2 , 3 For example, Roncaglioni et al 2 showed that the relative risk of myocardial infarction was 2.0 in those with one, and 3.0 in those with two or more first-degree relatives affected compared with those without a family history of myocardial infarction. (
  • INTRODUCTION Chest pain is the most usual symptom at presentation in patients with acute myocardial infarction (AMI), even if it ishighly subjective, and the pain characteristics, severity and emotional consequences may vary widely.1, 2 An asymptomatic AMI is not necessarily less severe than a symptomatic event. (
  • Thus, the use of morphine could be reserved for patients with pulmonary oedema or persistent severe chest pain after the administration of drugs that favorably alter myocardial oxygen supply and demand while waiting for timely reperfusion. (
  • Chest pain occurred clinically in six of the seven patients and ECG findings typical of infarction were found in two patients. (
  • Although the most well-known symptom of myocardial infarction is chest pain, not everyone experiences this symptom, informs National Heart, Lung and Blood Institute. (
  • Approximately one quarter of all myocardial infarctions are silent, without chest pain or other symptoms. (
  • Chest pain that may or may not radiate to other parts of the body is the most typical and significant symptom of myocardial infarction. (
  • Chest pain is the most common symptom of acute myocardial infarction and is often described as a sensation of tightness, pressure, or squeezing. (
  • Successful Myocardial Reperfusion, C. Michael Gibson, M.D. (
  • Thrombus Aspiration Before Standard Primary Angioplasty Improves Myocardial Reperfusion in Acute Myocardial Infarction. (
  • 2003) Prognostic significance of atrial fibrillation/atrial flutter in patients with acute myocardial infarction treated with percutaneous coronary intervention. (
  • Treatments, trends, and outcomes of acute myocardial infarction and percutaneous coronary intervention. (
  • The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. (
  • In some cases, the cause of myocardial infarction may be atherosclerotic plaques which occurred in the human aorta. (
  • With atypical cases of myocardial infarction, there is abdominal pain, laborious breathing, or dyspnea [ 3 , 4 ]. (
  • We report here the first (to our knowledge) cases of myocardial infarction (MI) after smoking K2. (
  • Defibrillator implantation early after myocardial infarction. (
  • Although the benefits of beta-adrenergic blockers after acute myocardial infarction have been apparent since the early 1980s, there has been, in recent years, a tremendous resurgence of interest in the use of beta blockers in the short- and long-term management of myocardial infarction. (
  • GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. (
  • A myocardial infarction , or heart attack, is the death or damage of part of the heart muscle because the supply of blood to the heart muscle is severely reduced or stopped. (
  • More than 1.5 million Americans suffer a myocardial infarction every year, and nearly half a million die, according to the American Heart Association. (
  • Myocardial infarctions are commonly called heart attacks. (
  • The longer the artery remains blocked during a myocardial infarction, the more damage will be done to the heart. (
  • Although the patient feels no pain, silent myocardial infarctions still damage the heart. (
  • The outcome of a myocardial infarction depends on the location of the blockage, whether the heart rhythm is disturbed, and whether there is collateral circulation to the territory supplied by the acutely occluded coronary artery. (
  • Later evidence indicated, however, that, though thrombotic occlusion of an atheromatous lesion in a coronary artery is the most common cause of the disorder, the manifestations are the result of the death of an area of heart muscle (infarction). (
  • In most persons who experience an acute myocardial infarction, the circulation remains adequate, and only by subtle evidence such as rales (abnormal respiratory sounds) in the lungs or a gallop rhythm of the heartbeat may the evidence of some minor degree of heart failure be detected. (
  • In some individuals the damage caused by the infarction may interfere with the functioning of the mitral valve , the valve between the left upper and lower chambers, and result in a form of valvular heart disease. (
  • Their occurrence often indicates myocardial dysfunction and they may, by themselves, cause congestive heart failure or exacerbate ongoing myocardial ischemia. (
  • Scientists have discovered a link between ambient air pollution and acute myocardial infarction, or heart attack. (
  • Acute myocardial infarction is the medical name for a heart attack. (
  • A heart attack or myocardial infarction is a medical emergency in which the supply of blood to the heart is suddenly and severely reduced or cut off, causing the muscle to die from lack of oxygen . (
  • More than 1.1 million people experience a heart attack ( myocardial infarction ) each year, and for many of them, the heart attack is their first symptom of coronary artery disease . (
  • A heart attack ( myocardial infarction ) is usually caused by a blood clot that blocks an artery of the heart . (
  • A listing of Heart Attack (Myocardial Infarction) medical research trials actively recruiting patient volunteers. (
  • High blood pressure is a risk factor for coronary heart disease, myocardial infarction and stroke and is very common in older adults. (
  • What percentage of adults report having coronary heart disease (CHD), including myocardial infarction and angina? (
  • A heart attack, or myocardial infarction (MI), is permanent damage to the heart muscle. (
  • Myo' means muscle, 'cardial' refers to the heart, and 'infarction' means death of tissue due to lack of blood supply. (
  • These symptoms could be the signs of a heart attack (also called myocardial infarction or MI) and immediate treatment is essential. (
  • We assessed the effects of atorvastatin treatment pre‐ and post‐myocardial infarction on cardiovascular function and glucose transporter 4 (GLUT4) in the heart. (
  • It is the only system that thereby recognizes infarctions of the anterior, lateral and posterior walls of the heart. (
  • Despite multiple NICE published guidance, quality standards, and technology appraisals, to reduce the burden of coronary heart disease (CHD) and Myocardial Infarction (MI), many patients with CHD are on suboptimal secondary prevention therapy, and around 40% of them are not adhering to these lifesaving therapies. (
  • 2006) Previously known and newly diagnosed atrial fibrillation: A major risk indicator after a myocardial infarction complicated by heart failure or left ventricular dysfunction. (
  • 2005) Prognostic significance of new atrial fibrillation and its relation to heart failure following acute myocardial infarction. (
  • And remember, in medicine, we call heart attacks myocardial infarcts. (
  • So myocardial referring to muscle, muscle of the heart, and infract referring to lack of oxygen causing death of tissue. (
  • A heart attack also is called a myocardial infarction. (
  • Myocardial infarction, commonly referred to as a heart attack, is caused by a disruption of blood flow to the heart, notes British Heart Foundation. (
  • In addition, nausea, indigestion, abdominal pain, heartburn, shortness of breath, fatigue and dizziness are common signs of myocardial infarction that involve parts of the anatomy other than the heart. (
  • An anterior myocardial infarction is a heart attack involving the left anterior descending artery of the heart, defines Cath Lab Digest. (
  • The ECG changes that accompany acute infarction include inverted T-waves, elevation and depression of the ST segment, variations in the QRS complex, and cresting of the T waves, behavior alternately known as hyperacute T-wave change, reports the American Heart Association. (
  • 1. HEART ATTACK = MYOCARDIAL INFARCTION = MI (this describes the complete blockage of a coronary vessel). (
  • With total blockage of blood flow the heart muscle will die resulting in a myocardial infarction. (
  • When the blood flow is COMPLETELY interrupted, myocardial infarction (heart attack) results. (
  • Optimal stem cell therapy delivery to damaged areas of the heart after myocardial infarction has been hampered by inefficient homing of cells to the damaged site. (
  • Myocardial infarction, commonly known as a heart attack, can happen at any moment. (
  • Myocardial infraction is a result of a blockage in any one of the coronary arteries leading to lack of oxygen in the heart. (
  • Siblings aged 35 to 74 years, unaffected by myocardial infarction, were drawn from the Augsburg Family Heart Study, conducted in 1996-1997 in southern Germany ( n = 524). (
  • The American Heart Association and the American College of Cardiology emphasize the importance of beta blockade in their current treatment guidelines for myocardial infarction. (
  • The phrase "heart attack" is often used non-specifically to refer to myocardial infarction. (
  • A myocardial infarction may compromise the function of the heart as a pump for the circulation, a state called heart failure. (
  • Ventricular free wall rupture following acute myocardial infarction. (
  • Acute myocardial infarction with rupture and tamponade, gross. (
  • These findings suggest that cholesterol crystals could play a critical role in plaque rupture, as well as vascular and myocardial injury. (
  • The common pathology of myocardial infarction is described as plaque build up within one of the coronary arteries or branches, which can rupture and form a. (
  • This myocardial scarring also puts the patient at risk for potentially life threatening arrhythmias , and may result in the formation of a ventricular aneurysm that can rupture with catastrophic consequences. (
  • Myocardial rupture is most common three to seven days after myocardial infarction, commonly of small degree, but may occur one day to three weeks later. (
  • In the modern era of early revascularization and intensive pharmacotherapy as treatment for MI, the incidence of myocardial rupture is about 1% of all MIs. (
  • Risk factors for myocardial rupture include completion of infarction (no revascularization performed), female sex, advanced age, and a lack of a previous history of myocardial infarction. (
  • A circadian perspective on myocardial ischaemia. (
  • 2, 3 Routine activities of daily life such as physical exertion and smoking, 4 as well as a variety of negative emotions such as anger, tension, and sadness, 5 were found to induce myocardial ischaemia. (
  • Electrocardiography (ECG) demonstrates classic findings of deep Q waves, peaked T waves, or ST segment changes consistent with ischemia, injury, or infarction. (
  • The high-sensitivity assay reclassified 1,771 (17%) patients with myocardial injury or infarction not identified by the standard assay. (
  • In order to recognize abnormalities that suggest ischemia or infarction, it is important to understand the components of a normal ECG. (
  • Hypothetically, manipulation of the intramural coronary artery may cause damage and resultant inflammation, kinking, thrombosis, and myocardial ischemia or infarction (see Transposition of the Great Arteries ). (
  • There are 32.4 million myocardial infarctions and strokes worldwide every year. (
  • Worldwide, about 15.9 million myocardial infarctions occurred in 2015. (
  • What Does an Anterior Myocardial Infarction ECG Look Like? (
  • Anterior myocardial infarction electrocardiograms, or ECGs, may contain convex patterns reminiscent of a row of tombstones, or simply exhibit particular J point, T-wave or ST-segment patterns that may be accompanied by inchoate tombstone forms with lateral and septal aspects, explains Healio. (
  • These individuals do, however, have an increased potential for subsequent myocardial infarction. (
  • An episode of shingles, caused by the herpes zoster virus, temporarily increases the risk for stroke and potentially myocardial infarction (MI) in the months after the infection, according to two recent studies. (
  • Evidence demonstrates that chronic stress doubles the risk of myocardial infarction and contributes to proinflammatory processes implicated in coronary artery disease and stroke. (
  • According to the researchers, it is unlikely the weight loss is the only reason for the study's observed correlation between metabolic surgery and a lower risk of cardiopathic events, such as stroke, myocardial infarction or early death. (
  • Despite aggressive therapeutic strategies, prognosis remains poor in patients with big infarction and severe left ventricular dysfunction. (
  • The greatest benefit was seen, however, in high-risk patients, including the elderly and those with large anterior infarctions, arrhythmias or left ventricular dysfunction. (
  • Myocardial bridging usually has a benign prognosis, but some cases associated with myocardial ischemia , infarction , and sudden death have been reported [1-5]. (
  • The seriousness of coronary artery disease is heightened by the fact that approximately a third of patients present with sudden death as their first manifestation, 1 and efforts to prevent infarctions before they occur have fuelled an area of research which investigates inciting events, or "triggers", of MI, arrhythmias, and sudden death. (
  • A myocardial infarction is often the first detected symptom of coronary artery disease . (
  • In acute myocardial infarction, ECG changes are time dependent so that the time between symptom onset and ECG recording (hence presentation to care) affects the ability to capture ST-segment elevation on the ECG. (
  • The incidence, mechanism, and treatment of supraventricular arrhythmias (particularly sinus bradycardia, sinus tachycardia, and atrial fibrillation) occurring after myocardial infarction (MI) will be reviewed here. (
  • 6 The data from these studies indicate that, although deaths from coronary disease have declined, the incidence of myocardial infarction in the United States has remained mostly stable. (
  • To test the hypothesis that low levels of free protein S, a natural anticoagulant protein in plasma, were associated with an increased incidence of myocardial infarction in middle aged men and women. (
  • The goal was to determine if low levels of free protein S were associated with an increased incidence of myocardial infarction. (
  • 2001) Incidence and prognostic significance of atrial fibrillation in acute myocardial infarction: The GISSI-3 data. (
  • 2002) Recent trends in the incidence rates of and death rates from atrial fibrillation complicating initial acute myocardial infarction: A community-wide perspective. (
  • The link between hypertension and the incidence of non-fatal and fatal myocardial infarction is also well known. (
  • Scar remodelling and transmural deformation after infarction in the pig. (
  • Gaudron P, Hu K, Schamberger R, Budin M, Walter B, Ertl G. Effect of endurance training early or late after coronary artery occlusion on left ventricular remodeling, hemodynamics, and survival in rats with chronic transmural myocardial infarction. (
  • The traditional concept that myocardial infarctions can be classified as transmural or nontransmural on the basis of the presence or absence of Q waves is misleading, since autopsy studies have demonstrated convincingly that pathologic Q waves may be associated with nontransmural infarction and may be absent with transmural infarction . (
  • Occlusive intracoronary thrombus - a thrombus overlying an ulcerated or fissured stenotic plaque causes 90% of transmural acute myocardial infarctions . (
  • To determine whether the administration of intravenous streptokinase (SK) early in the course of acute, transmural myocardial infarction would limit myocardial damage. (
  • An unusually high prevalence of glycosuria in nondiabetic patients who have acute myocardial infarction (MI) was noted as early as 1931 ( 1 ). (
  • 2000) Acute myocardial infarction complicated by atrial fibrillation in the elderly: Prevalence and outcomes. (
  • Prevalence during autopsy has been described in multiple studies, varying widely from five to 85 percent, but most studies cite myocardial bridging prevalence between 20 and 55 percent. (
  • What Is the Common Pathology of Myocardial Infarction? (
  • 2. Health Economics Group, Peninsula College of Medicine Dentistry, Exeter University, Exeter,United Kingdom KEYWORDS Abstract Aims: The aims of this review are to identify and evaluate studies exploring the cost-effectiveness of primary angioplasty (PPCI) vs. thrombolysis (TL) for treating acute myocardial infarction (AMI). (
  • Capnocytophaga canimorsus sepsis complicated by myocardial infarction in two patients with normal coronary arteries. (
  • Acute myocardial infarction is a leading cause of death worldwide, and is responsible for approximately 42% of all deaths from cardiovascular disease. (
  • Areas of myocardial infarction may be subepicardial if there is occlusion of smaller vessels by thromboemboli originating from coronary thrombi. (
  • Wistar-Kyoto rats were treated with 20 mg/kg atorvastatin or vehicle for 14 days before coronary artery occlusion surgery (myocardial infarction) or sham surgery. (
  • First, they support and extend previous reports of a decline in the severity of myocardial infarction as reported in studies that examined severity indicators in ARIC, Worcester, and Olmsted County. (
  • Second, these data provide the important opportunity of an in-depth reflection on the meaning and implications of measuring the severity of myocardial infarction, a complex construct reflecting the composite result of disease severity indicators, care-seeking behaviors, and processes of care. (
  • For ease of discussion, the indicators of severity of myocardial infarction can be schematically envisioned as reflecting the initial presentation of infarction or its in-hospital course. (
  • Study of these mechanisms has been stimulated by the finding that the onset of acute myocardial infarction is more likely during the morning hours after awakening, suggesting that activities of the patient often trigger the event. (
  • Myocardial infarction onset within six hours. (
  • 2010) Relationship of functional mitral regurgitation to new-onset atrial fibrillation in acute myocardial infarction. (
  • Mr Smith described the onset of the infarction as abrupt with severe pain radiating to his left arm, jaw and neck. (
  • A number of factors have been associated with the onset of myocardial infarction, including physical exertion, drug abuse, heavy meals, stress, or increases in air pollution. (
  • In a discovery sample of 2,967 cases of early-onset myocardial infarction (MI) and 3,075 controls from the MIGen study, we performed pair-wise SNP interaction testing using a logistic regression framework. (
  • Wearable cardioverter-defibrillator use in patients perceived to be at high risk early post-myocardial infarction. (
  • Use of some antiretroviral (ARV) drugs may increase the risk for a myocardial infarction. (
  • Who is at risk for acute myocardial infarction? (
  • Having high levels of cholesterol in your blood puts you at risk for acute myocardial infarction. (
  • 3 Controlling high blood pressure is shown to reduce the risk of fatal myocardial infarctions and strokes. (
  • In the Fibrinolytic Therapy Trialists' study, the absolute risk reduction in patients with inferior infarctions was 0.9% whereas it was 3.7% in patients with anterior infarctions. (
  • Free protein S (that portion of plasma protein S which is not in complex with C4b binding protein) is a cofactor for the anticoagulant effect of activated protein C. Patients presenting with acute myocardial infarction have significantly reduced levels of free protein S. If the major hypothesis proved correct, patients at high risk of myocardial infarction could be identified and could be targeted for future studies to examine specific intervention therapy. (
  • The measurement of other potential markers of risk by other laboratories, such as prothrombin fragment Fl+2 and factor X activation peptide, permitted a comprehensive evaluation of hemostatic risk factors in myocardial infarction. (
  • A second study was conducted in women to examine protein S as a risk factor for myocardial infarction. (
  • 2011) Restrictive left ventricular filling pattern and risk of newonset atrial fibrillation after acute myocardial infarction. (
  • Although prior studies have raised concern about the cardiovascular safety of these medications, detailed information on the risk of these medications in patients after myocardial infarction (MI) is lacking. (
  • Diet also plays an important role in reducing the risk for a myocardial infarction. (
  • One of the most modifiable risk factors of myocardial infarction is physical inactivity. (
  • You can modify your activity level so that you can reduce your risk of having a myocardial infarction. (
  • Researchers at Karolinska Institutet and Danderyd Hospital in Sweden have studied the risk of additional myocardial infarctions and early death in severely obese patients who undergo metabolic surgery following a myocardial event. (
  • The registry study covering 1,018 individuals shows a lower risk of additional myocardial infarctions and improved survival that cannot be simply attributed to the loss of weight. (
  • In the current study, researchers at Karolinska Institutet, Orebro University and Uppsala University examined the risk of additional myocardial infarction and early death in people with severe obesity and a previous infarction who subsequently underwent metabolic surgery. (
  • An earlier study, Look AHEAD, demonstrated that long, intensive non-surgical lifestyle intervention in patients with type 2 diabetes resulted in weight loss of 6 per cent, but did not lower the risk of myocardial infarction. (
  • In conclusion the siblings and their physicians should pay more attention to the family history of myocardial infarction in order to improve the management of hypertension in this high risk group. (
  • Therapy of symptomatic pericarditis after myocardial infarction: retrospective and prospective studies of aspirin, indomethacin, prednisone, and spontaneous resolution. (
  • Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor, more frequently clopidogrel, represents the standard of care for the long-term secondary prevention of atherothrombotic events in patients with myocardial infarction (MI) or peripheral arterial disease (PAD). (
  • Determination of the potential value of thrombolytic therapy in patients with acute myocardial infarction was an issue of major importance in 1983. (
  • Comments on the efficacy of aspirin therapy in preventing myocardial infarctions. (
  • 4 On the basis of these guidelines, the Health Care Financing Administration (HCFA) and the National Coalition for Quality Assurance (NCQA) have identified beta-blocker therapy after myocardial infarction as a critical marker for quality of care. (
  • Cardiogenic shock and ECG ST-segment elevation reflect the initial presentation of myocardial infarction and its characteristics during the initial 24 hours and are unlikely to be affected by in-hospital treatment. (
  • This, in turn, may change the case mix of hospitalized infarction, thereby confounding temporal trends in cardiogenic shock. (
  • Registries were used to record the primary outcome of myocardial infarction or cardiovascular death at one year. (
  • Normalisation of blood glucose levels following myocardial infarction predicts favourable in hospital outcome. (
  • It is well established that myocardial infarction (MI) associated with coronary artery bypass grafting (CABG) predicts a poor outcome. (