Mycobacterium bovis
Mycobacterium
Mycobacterium tuberculosis
Tuberculosis, Bovine
BCG Vaccine
Mycobacterium smegmatis
Tuberculosis
Mycobacterium avium
Nontuberculous Mycobacteria
So-called atypical species of the genus MYCOBACTERIUM that do not cause tuberculosis. They are also called tuberculoid bacilli, i.e.: M. buruli, M. chelonae, M. duvalii, M. flavescens, M. fortuitum, M. gilvum, M. gordonae, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. kansasii, M. marinum, M. obuense, M. scrofulaceum, M. szulgai, M. terrae, M. ulcerans, M. xenopi.
Streptococcus bovis
Mycobacterium leprae
Mycobacterium Infections, Nontuberculous
Infections with nontuberculous mycobacteria (atypical mycobacteria): M. kansasii, M. marinum, M. scrofulaceum, M. flavescens, M. gordonae, M. obuense, M. gilvum, M. duvali, M. szulgai, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. xenopi (littorale), M. ulcerans, M. buruli, M. terrae, M. fortuitum (minetti, giae), M. chelonae.
Mycobacterium avium Complex
A complex that includes several strains of M. avium. M. intracellulare is not easily distinguished from M. avium and therefore is included in the complex. These organisms are most frequently found in pulmonary secretions from persons with a tuberculous-like mycobacteriosis. Strains of this complex have also been associated with childhood lymphadenitis and AIDS; M. avium alone causes tuberculosis in a variety of birds and other animals, including pigs.
Mycoplasma bovis
Mycobacterium fortuitum
Babesia bovis
Mycobacterium kansasii
Mycobacterium marinum
Mycobacterium chelonae
Mycobacterium avium subsp. paratuberculosis
Antitubercular Agents
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
Moraxella (Moraxella) bovis
Cattle
Mycobacterium ulcerans
Mustelidae
Tuberculin
Mycobacterium avium-intracellulare Infection
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Isoniazid
Deer
The family Cervidae of 17 genera and 45 species occurring nearly throughout North America, South America, and Eurasia, on most associated continental islands, and in northern Africa. Wild populations of deer have been established through introduction by people in Cuba, New Guinea, Australia, New Zealand, and other places where the family does not naturally occur. They are slim, long-legged and best characterized by the presence of antlers. Their habitat is forests, swamps, brush country, deserts, and arctic tundra. They are usually good swimmers; some migrate seasonally. (Walker's Mammals of the World, 5th ed, p1362)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Tuberculin Test
Granuloma
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Carnivora
Paratuberculosis
Bacterial Typing Techniques
Leprosy
Hypersensitivity, Delayed
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Vaccination
Rifampin
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Lung
Cord Factors
Polymorphism, Restriction Fragment Length
Mycobacterium scrofulaceum
Mycobacteriophages
Cattle Diseases
DNA Fingerprinting
A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.
Minisatellite Repeats
Tandem arrays of moderately repetitive, short (10-60 bases) DNA sequences which are found dispersed throughout the GENOME, at the ends of chromosomes (TELOMERES), and clustered near telomeres. Their degree of repetition is two to several hundred at each locus. Loci number in the thousands but each locus shows a distinctive repeat unit.
Mycobacterium xenopi
Base Sequence
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Ethambutol
An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)
Animals, Wild
DNA Transposable Elements
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
Virulence
Chaperonin 60
A group I chaperonin protein that forms the barrel-like structure of the chaperonin complex. It is an oligomeric protein with a distinctive structure of fourteen subunits, arranged in two rings of seven subunits each. The protein was originally studied in BACTERIA where it is commonly referred to as GroEL protein.
Microbial Sensitivity Tests
Glycolipids
Cell Wall Skeleton
Colony Count, Microbial
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Vaccines, Synthetic
Chaperonins
A family of multisubunit protein complexes that form into large cylindrical structures which bind to and encapsulate non-native proteins. Chaperonins utilize the energy of ATP hydrolysis to enhance the efficiency of PROTEIN FOLDING reactions and thereby help proteins reach their functional conformation. The family of chaperonins is split into GROUP I CHAPERONINS, and GROUP II CHAPERONINS, with each group having its own repertoire of protein subunits and subcellular preferences.
Sensitivity and Specificity
Guinea Pigs
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Amino Acid Sequence
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Sequence Analysis, DNA
Gene Expression Regulation, Bacterial
Mycobacterium haemophilum
Acyltransferases
Macrophage Activation
The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.
Cell Wall
Immunity, Cellular
Drug Resistance, Bacterial
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Lymph Nodes
Administration, Intravesical
Sputum
Skin Tests
Tuberculosis, Meningeal
A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)
Immunization, Secondary
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Moraxella
Cells, Cultured
Microbial Viability
Tuberculosis, Multidrug-Resistant
Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
RNA, Ribosomal, 16S
Armadillos
Bison
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Disease Reservoirs
Animate or inanimate sources which normally harbor disease-causing organisms and thus serve as potential sources of disease outbreaks. Reservoirs are distinguished from vectors (DISEASE VECTORS) and carriers, which are agents of disease transmission rather than continuing sources of potential disease outbreaks.
Immunity, Innate
Vaccines, Attenuated
Toll-Like Receptor 2
Cross Reactions
Vaccines, DNA
Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
CD4-Positive T-Lymphocytes
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Th1 Cells
Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
RNA, Bacterial
Tuberculosis, Pleural
Phagosomes
Tuberculosis, Cardiovascular
Cloning, Molecular
Leukocytes, Mononuclear
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Molecular Epidemiology
Tuberculosis, Cutaneous
Sus scrofa
Drug Resistance, Microbial
DNA Primers
Buffaloes
Molecular Typing
Interspersed Repetitive Sequences
Copies of transposable elements interspersed throughout the genome, some of which are still active and often referred to as "jumping genes". There are two classes of interspersed repetitive elements. Class I elements (or RETROELEMENTS - such as retrotransposons, retroviruses, LONG INTERSPERSED NUCLEOTIDE ELEMENTS and SHORT INTERSPERSED NUCLEOTIDE ELEMENTS) transpose via reverse transcription of an RNA intermediate. Class II elements (or DNA TRANSPOSABLE ELEMENTS - such as transposons, Tn elements, insertion sequence elements and mobile gene cassettes of bacterial integrons) transpose directly from one site in the DNA to another.
Macrophages, Alveolar
Chromatography, Thin Layer
Zoonoses
Coyotes
Evaluation Studies as Topic
Reagent Kits, Diagnostic
Genotype
CD8-Positive T-Lymphocytes
Bacterial Vaccines
Mutation
Gene Deletion
Lipopolysaccharides
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Oligonucleotides
DNA Probes
Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
Veterinary Medicine
Reindeer
A genus of deer, Rangifer, that inhabits the northern parts of Europe, Asia, and America. Caribou is the North American name; reindeer, the European. They are often domesticated and used, especially in Lapland, for drawing sleds and as a source of food. Rangifer is the only genus of the deer family in which both sexes are antlered. Most caribou inhabit arctic tundra and surrounding arboreal coniferous forests and most have seasonal shifts in migration. They are hunted extensively for their meat, skin, antlers, and other parts. (From Webster, 3d ed; Walker's Mammals of the World, 5th ed, p1397)
Phagocytosis
Alanine Dehydrogenase
An NAD-dependent enzyme that catalyzes the reversible DEAMINATION of L-ALANINE to PYRUVATE and AMMONIA. The enzyme is needed for growth when ALANINE is the sole CARBON or NITROGEN source. It may also play a role in CELL WALL synthesis because L-ALANINE is an important constituent of the PEPTIDOGLYCAN layer.
Polysorbates
Goats
Babesiosis
Mycobacteriaceae
Streptomycin
Milk
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Monocytes
Cluster Analysis
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
Interleukin-12
A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
Ebenaceae
Granuloma, Respiratory Tract
Trichosurus
Glycine Dehydrogenase
Receptors, Antigen, T-Cell, gamma-delta
T-cell receptors composed of CD3-associated gamma and delta polypeptide chains and expressed primarily in CD4-/CD8- T-cells. The receptors appear to be preferentially located in epithelial sites and probably play a role in the recognition of bacterial antigens. The T-cell receptor gamma/delta chains are separate and not related to the gamma and delta chains which are subunits of CD3 (see ANTIGENS, CD3).
Disease Models, Animal
Clofazimine
A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
Sequence Homology, Amino Acid
Antelopes
Disease Susceptibility
Immunoglobulin G
Injections, Intradermal
T-Lymphocyte Subsets
Generation of CD8(+) T-cell responses to Mycobacterium bovis and mycobacterial antigen in experimental bovine tuberculosis. (1/2326)
Protective immunity against tuberculosis is considered to be essentially cell mediated, and an important role for CD8(+) T lymphocytes has been suggested by several studies of murine and human infections. The present work, using an experimental model of infection with Mycobacterium bovis in cattle, showed that live M. bovis elicits the activation of CD8(+) T cells in vitro. However, a sonic extract prepared from M. bovis (MBSE) and protein purified derivative (PPDb) also induced a considerable degree of activation of the CD8(+) T cells. Analysis of proliferative responses of peripheral blood mononuclear cells, purified CD8(+) T cells, and CD8(+) T-cell clones to M. bovis and to soluble antigenic preparations (MBSE, PPDb) showed that the responses of all three types of cells were always superior for live mycobacteria but that strong responses were also obtained with complex soluble preparations. Furthermore, while cytotoxic capabilities were not investigated, the CD8(+) T cells were found to produce and release gamma interferon in response to antigen (live and soluble), which indicated one possible protective mechanism for these cells in bovine tuberculosis. Finally, it was demonstrated by metabolic inhibition with brefeldin A and cytochalasin D at the clonal level that an endogenous pathway of antigen processing is required for presentation to bovine CD8(+) cells and that presentation is also dependent on phagocytosis of the antigen. (+info)Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophages. (2/2326)
When the lethal action of a C-8 methoxyl fluoroquinolone against clinical isolates of Mycobacterium tuberculosis in liquid medium was measured, the compound was found to be three to four times more effective (as determined by measuring the 90% lethal dose) than a C-8-H control fluoroquinolone or ciprofloxacin against cells having a wild-type gyrA (gyrase) gene. Against ciprofloxacin-resistant strains, the C-8 methoxyl group enhanced lethality when alanine was replaced by valine at position 90 of the GyrA protein or when aspartic acid 94 was replaced by glycine, histidine, or tyrosine. During infection of a human macrophage model by wild-type Mycobacterium bovis BCG, the C-8 methoxyl group lowered survival 20- to 100-fold compared with the same concentration of a C-8-H fluoroquinolone. The C-8 methoxyl fluoroquinolone was also more effective than ciprofloxacin against a gyrA Asn94 mutant of M. bovis BCG. In an M. tuberculosis-macrophage system the C-8 methoxyl group improved fluoroquinolone action against both quinolone-susceptible and quinolone-resistant clinical isolates. Thus, a C-8 methoxyl group enhances the bactericidal activity of quinolones with N1-cyclopropyl substitutions; these data encourage further refinement of fluoroquinolones as antituberculosis agents. (+info)Observations on animal and human health during the outbreak of Mycobacterium bovis in game farm wapiti in Alberta. (3/2326)
This report describes and discusses the history, clinical, pathologic, epidemiologic, and human health aspects of an outbreak of Mycobacterium bovis infection in domestic wapiti in Alberta between 1990 and 1993, shortly after legislative changes allowing game farming. The extent and seriousness of the outbreak of M. bovis in wapiti in Alberta was not fully known at its onset. The clinical findings in the first recognized infected wapiti are presented and the postmortem records for the herd in which the animal resided are summarized. Epidemiologic findings from the subsequent field investigation are reviewed, the results of recognition and investigation of human exposure are updated, and recommendations for reduction of human exposure are presented. (+info)Molecular markers demonstrate that the first described multidrug-resistant Mycobacterium bovis outbreak was due to Mycobacterium tuberculosis. (4/2326)
We genetically characterized multidrug-resistant Mycobacterium tuberculosis complex strains which caused a nosocomial outbreak of tuberculosis affecting six human immunodeficiency virus (HIV)-positive patients and one HIV-negative staff member (E. Bouvet, E. Casalino, G. Mendoza-Sassi, S. Lariven, E. Vallee, M. Pernet, S. Gottot, and F. Vachon, AIDS 7:1453-1460, 1993). The strains showed all the phenotypic characteristics of Mycobacterium bovis. They presented a high copy number of IS6110, the spacers 40 to 43 in the direct repeat locus, and the mtp40 fragment. They lacked the G-A mutation at position 285 in the oxyR gene and the C-G mutation at position 169 in the pncA gene. These genetic characteristics revealed that these were dysgonic, slow-growing M. tuberculosis strains mimicking the M. bovis phenotype, probably as a consequence of cellular alterations associated with the multidrug resistance. Spoligotyping and IS6110 restriction fragment length polymorphism (RFLP) analysis confirmed that the outbreak was due to a single strain. However, the IS6110 RFLP pattern of the strain isolated from the last patient, diagnosed three years after the index case, differed slightly from the patterns of the other six strains. A model of a possible genetic event is presented to explain this divergence. This study stresses the value of using several independent molecular markers to identify multidrug-resistant tubercle bacilli. (+info)Characterization of exochelins of the Mycobacterium bovis type strain and BCG substrains. (5/2326)
Pathogenic mycobacteria must acquire iron in the host in order to multiply and cause disease. To do so, they release abundant quantities of siderophores called exochelins, which have the capacity to scavenge iron from host iron-binding proteins and deliver it to the mycobacteria. In this study, we have characterized the exochelins of Mycobacterium bovis, the causative agent of bovine and occasionally of human tuberculosis, and the highly attenuated descendant of M. bovis, bacillus Calmette-Guerin (BCG), widely used as a vaccine against human tuberculosis. The M. bovis type strain, five substrains of M. bovis BCG (Copenhagen, Glaxo, Japanese, Pasteur, and Tice), and two strains of virulent Mycobacterium tuberculosis all produce the same set of exochelins, although the relative amounts of individual exochelins may differ. Among these mycobacteria, the total amount of exochelins produced is greatest in M. tuberculosis, intermediate in M. bovis, and smallest in M. bovis BCG. (+info)Characterization of mannooligosaccharide caps in mycobacterial lipoarabinomannan by capillary electrophoresis/electrospray mass spectrometry. (6/2326)
A new analytical approach based on capillary electrophoresis-electrospray mass spectrometry (CE/ESI-MS) has provided new insight into the characterization of mannooligosaccharide caps from lipoarabinomannans (LAMs), which are key molecules in the immunopathogenesis of tuberculosis. This analytical approach requires oligosaccharide labeling with the fluorophore 1-aminopyrene-3,6,8-trisulfonate (APTS) by reductive amination at the reducing termini. Optimization of the separation and ionization conditions, such as the choice of capillary electrophoresis (CE) electrolyte buffers, is presented and discussed. Anionic separation of the mono and oligosaccharide APTS derivatives was finally achieved with aqueous triethylammonium formate buffer. It was found that in contrast to the triethylammonium phosphate buffer, the triethylammonium formate buffer was appropriate for CE/ESI-MS coupling analysis of APTS-carbohydrate derivatives. In this case, negative ESI-mass spectra of APTS-carbohydrate adducts showed mainly (M-2H)2-pseudomolecular ions and some sequence fragment ions allowing their non-ambiguous structural characterization at the picomolar level. This analytical approach was successfully applied to more complex mixtures of carbohydrates released by mild acid hydrolysis of the lipoarabinomannans from Mycobacterium bovis BCG. The APTS-mannooligosaccharide cap adducts were separated by CE and their structural characterization achieved by CE/ESI-MS analyses. Mannooligosaccharide caps were routinely analyzed by capillary electrophoresis-laser induced fluorescence (CE-LIF) from 50 fmol of lipoarabinomannans with mannosyl capping (ManLAMs) but sensitivity was about 50 times lower using ESI-MS detection. (+info)Oxygen depletion-induced dormancy in Mycobacterium bovis BCG. (7/2326)
Gradual depletion of oxygen causes the shift-down of aerobic growing Mycobacterium bovis BCG to an anaerobic synchronized state of nonreplicating persistence. The persistent culture shows induction of glycine dehydrogenase and alpha-crystallin-like protein and is sensitive to metronidazole. (+info)Different strategies for molecular differentiation of Mycobacterium bovis strains isolated in Sardinia, Italy. (8/2326)
Different genetic markers were used to analyze 22 Mycobacterium bovis strains isolated from cattle in Sardinia and one human isolate. IS6110 DNA fingerprinting differentiated the strains into six patterns, whereas with enterobacterial repetitive consensus sequence primers produced seven clusters. PCR ribotyping followed by digestion with HaeIII and PvuII produced five and seven patterns, respectively. PCR with the (GTG)5 oligonucleotide primer showed the best discriminatory power, generating eight clusters among the strains analyzed. (+info)
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SWISS-MODEL Repository | A1KMP2
A1KNE3 | SWISS-MODEL Repository
Characterisation of a lipoprotein in Mycobacterium bovis (BCG) with sequence similarity to the secreted protein MPB70. -...
Correlation of ESAT-6-Specific Gamma Interferon Production with Pathology in Cattle following Mycobacterium bovis BCG...
Pharmaceutical Microbiology: Mycobacterium bovis (M. bovis): reducing the risk of human infection
Zoonotic Mycobacterium bovis : induced tuberculosis in humans
Paper Alert 7 | Bladder Cancer
Cat-to-Human Transmission of Mycobacterium bovis, United Kingdom - Volume 25, Number 12-December 2019 - Emerging Infectious...
Re: [Histonet] CD138 and Mycobacterium bovis
RCSB PDB - 2KKL: Solution NMR structure of FHA domain of Mb1858 from Mycobacterium bovis. Northeast Structural Genomics...
In vivo efficiency of targeted norfloxacin against persistent, isoniazid-insensitive, Mycobacterium bovis BCG present in the...
BCG infections | Publisso
Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG immunized adults...
par genes in Mycobacterium bovis and Mycobacterium smegmatisare arranged in an operon transcribed from SigGC promoters | BMC...
Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. | Nat Immunol;19(9...
Bacillus Of Calmette and Guerin Vaccine, Live - Healthery
Desenvolvimento de cepas de Mycobacterium bovis Calmette-Guérin (BCG) e Mycobacterium...
Production of MPT-64 recombinant protein from virulent strain of Mycobacterium bovis
Phase I study of immunotherapy with methanol extraction residue (MER) of bacillus Calmette Guerin<...
Molecular characterization of Mycobacterium bovis strains isolated from cattle slaughtered at two abattoirs in Algeria | BMC...
BCG (Bacillus Calmette - Guerin) Availability - HPS
Late Presentation of Disseminated Bacillus Calmette-Guerin infection in an Immunocompetent Male: a Case Report | Canadian...
Failure of a Mycobacterium tuberculosis ΔRD1 ΔpanCD double deletion mutant in a neonatal calf aerosol M. bovis challenge model:...
Molecular confirmation of Bacillus Calmette Guerin vaccine related adverse events among Saudi Arabian children. | Sigma-Aldrich
Intracellular Destruction of Leishmania Tropica by Macrophages Activated in Vivo with Mycobacterium Bovis Strain BCG |...
Mycocerosic acid synthase elisa and antibody
Effect of skin testing and segregation on the prevalence of bovine tuberculosis, and molecular typing of Mycobacterium bovis,...
The Effect of Bacille Calmette Guerin (BCG) Vaccination on Immune Responses in HIV-Exposed and Unexposed Infants - Full Text...
The Effect of Bacille Calmette Guerin (BCG) Vaccination on Immune Responses in HIV-Exposed and Unexposed Infants - Full Text...
Therapeutic Action Research of Bacille Calmette Guerin (BCG) on a Systemic Lupus
Erythematosus Mouse Model | SciTechnol
Bacillus Calmette-Guerin Vaccine, BCG - MedsChat
Browsing CSU Theses and Dissertations by Title T cell independent mechanisms for protection against Mycobacterium tuberculosis...
Identification of Mycobacterium bovis Isolates by a multiplex PCR
INTRAMUSCULAR BCG VACCINATION REDUCES SIGNIFICANTLY THE PATHOLOGY INDUCED BY MYCOBACTERIUM BOVIS IN BADGERS (MELES MELES) -...
Mycobacterium bovis infection in the Eurasian badger (Meles meles): the disease, pathogenesis, epidemiology and control. -...
Bovine Tuberculosis/Mycobacterium bovis Ab Test - IDEXX US
Bovine Tuberculosis/Mycobacterium bovis Ab test - IDEXX Canada
Performance of an environmental test to detect Mycobacterium bovis infection in badger social groups | Veterinary Record
Publication : USDA ARS
RRC: Experimental Mycobacterium bovis infection in three white rhinoceroses (Ceratotherium simum): Susceptibility, clinical and...
ORBi: Browsing ORBi
A study of the practical challenges associated with developing a new test for bovine tuberculosis - Nottingham ePrints
Neonatal vaccination with Mycobacterium bovis BCG: potential effects as a priming agent shown in a heterologous prime-boost...
Tuberculosis caused by<i> Mycobacterium bovis</i>, a re...
Differential effects of Mycobacterium bovis - derived polar and apolar lipid fractions on bovine innate immune cells - Surrey...
Mycobacterium bovis - Redorbit
Notes from the Field: Zoonotic Mycobacterium bovis Disease in Deer Hunters - Michigan, 2002-2017 | MMWR
2021 ICD-10-CM Diagnosis Code A31.0: Pulmonary mycobacterial infection
24/7 Pharmacy: Priligy in canada 10% discount!
Characterization of γδ T Cell Effector/Memory Subsets Based on CD27 and CD45R Expression in Response to Mycobacterium bovis...
A case of bovine tuberculosis in pigs in Poland - a country free from the disease
Tuberculosis - Free Capstone Project For Students
Vaccines | Free Full-Text | Nonclinical Development of BCG Replacement Vaccine Candidates
Department of Molecular Microbiology
MYCOBACTERIOSIS IN WILD BOARS: STUDY FOR THE USE OFLIQUID MEDIA AND ANTIBIOTIC RESISTANCE | Archivio Istituzionale della Ricerca
Subject: host strains / Journal: Tuberculosis / Publication Year: 2002 / Subject: bovine tuberculosis and Mycobacterium bovis...
Frontiers | The Humoral Immune Response to BCG Vaccination | Immunology
The complete genome sequence of Mycobacterium bovis | PNAS
MDL Test Order Mycobacterium tuberculosis Complex Identification
Macrophages as a source of tumoricidal activity (tumor-necrotizing factor) - University of Regensburg Publication Server
Most recent papers with the keyword Policy analysis | Read by QxMD
Most recent papers with the keyword structural factor | Read by QxMD
Mycobacterium bovis
... in African wildlife Mycobacterium bovis in African wildlife Tuberculosis - Mycobacterium bovis - Health ... Mycobacterium bovis is a slow-growing (16- to 20-hour generation time) aerobic bacterium and the causative agent of ... Delahay, R.J.; De Leeuw, A.N.S.; Barlow, A.M.; Clifton-Hadley, R.S.; Cheeseman, C.L. (2002). "The status of Mycobacterium bovis ... Phillips, C.J.C.; Foster, C.R.W.; Morris, P.A.; Teverson, R. (2001). "The transmission of Mycobacterium bovis infection to ...
Mycobacterium caprae
Kubica, T.; Rusch-Gerdes, S.; Niemann, S. (1 July 2003). "Mycobacterium bovis subsp. caprae Caused One-Third of Human M. bovis- ... Mycobacterium caprae is a species of bacteria in the genus Mycobacterium and a member of the Mycobacterium tuberculosis complex ... It is also synonymous with the name Mycobacterium bovis subsp. caprae.[citation needed] M. caprae is a causative agent of ... December 2009). "Human tuberculosis due to Mycobacterium bovis and M. caprae in Spain, 2004-2007". Int. J. Tuberc. Lung Dis. 13 ...
Ziehl-Neelsen stain
Mycobacterium bovis causes tuberculosis in cattle. Since tuberculosis can be spread to humans, milk is pasteurized to kill any ... The Mycobacteria species that causes tuberculosis (TB) in humans is Mycobacterium tuberculosis, which is an airborne bacterium ... The genus Mycobacterium is a slow growing bacteria, made up of small rods that are slightly curved or straight, and are ... Some mycobacteria are free-living saprophytes, but many are pathogens that cause disease in animals and humans. ...
Julian Parkhill
"The complete genome sequence of Mycobacterium bovis". Proceedings of the National Academy of Sciences. 100 (13): 7877-82. ... 1998). "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence". Nature. 393 (6685): 537-44. ... including Mycobacterium tuberculosis, Yersinia pestis and Salmonella typhi. As well as providing complete catalogues of the ...
List of sequenced bacterial genomes
2003). "The complete genome sequence of Mycobacterium bovis". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7877-82. Bibcode:2003PNAS ... 2005). "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis". Proc. Natl. Acad. Sci. U.S.A. 102 (35 ... 1998). "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence". Nature. 393 (6685): 537-44. ...
Tuberculosis
An effort to eradicate bovine tuberculosis caused by Mycobacterium bovis from the cattle and deer herds of New Zealand has been ... The M. tuberculosis complex (MTBC) includes four other TB-causing mycobacteria: M. bovis, M. africanum, M. canetti, and M. ... Thoen C, Lobue P, de Kantor I (February 2006). "The importance of Mycobacterium bovis as a zoonosis". Veterinary Microbiology. ... Mycobacteria infect many different animals, including birds, fish, rodents, and reptiles. The subspecies Mycobacterium ...
Lipoarabinomannan
Prinzis S, Chatterjee D, Brennan PJ (November 1993). "Structure and antigenicity of lipoarabinomannan from Mycobacterium bovis ... "Structural features of lipoarabinomannan from Mycobacterium bovis BCG. Determination of molecular mass by laser desorption mass ... purified from Mycobacterium chelonae and Mycobacterium kansasii induce TNF-alpha and IL-8 secretion by a CD14-toll-like ... These types of LAMs are most commonly found in more pathogenic Mycobacterium species such as M. tuberculosis, M. leprae, and M ...
Vertical transmission
... the molecular evolution of Mycobacterium bovis". Nature Reviews Microbiology. 4 (9): 670-681. doi:10.1038/nrmicro1472. ISSN ...
Maltokinase
"Biochemical characterization of the maltokinase from Mycobacterium bovis BCG". BMC Biochemistry. 11: 21. doi:10.1186/1471-2091- ...
Pyrazinamide
In particular, it is not used to treat other mycobacteria; Mycobacterium bovis and Mycobacterium leprae are innately resistant ... Pyrazinamide is only used in combination with other drugs such as isoniazid and rifampicin in the treatment of Mycobacterium ... Klemens, S.P.; Sharpe, C.A.; Cynamon, M.H. (1996). "Activity of pyrazinamide in a murine model against Mycobacterium ... 2011). "Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis". Science. 333 (6049): 1630-32. Bibcode:2011Sci ...
CpG oligodeoxynucleotide
"Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical ...
Mycobacterium suricattae
Prior to this, it was considered to be synonymous with Mycobacterium bovis. M. suricattae is transmitted by respiratory ... Drewe, J, Foote, A, Sutcliffe, R, Pearce, G (2009). "Pathology of Mycobacterium bovis infection in wild meerkats (Suricata ... Mycobacterium suricattae is a species of the tuberculosis complex of the genus Mycobacterium. It causes tuberculosis in ...
Urine-diverting dry toilet
"Survival of Mycobacterium tuberculosis and Mycobacterium bovis in human urine". Water Science & Technology. 63 (6): 1075-80. ... Storage of urine kills bacterial pathogens encountered in urine - including Salmonella typhi and paratyphi and Mycobacterium ... C has been recommended to prevent transmission of mycobacteria when recycling human urine. Recommended storage times to kill ...
Amanda M. Brown
"Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages". Infection and Immunity. 64 (5): 1794-1799. doi: ... SecA1 they found to be essential, but SecA2 they found to be nonessential but conserved across mycobacteria suggesting its ... Brown also explored the sec-dependent protein export pathway in mycobacterium, the main protein export pathway into the ... Brown helped to develop a novel method to study the mechanisms underlying mycobacterium replication in mononuclear phagocytes. ...
Mycotoxin
Kuria, Joseph N.; Gathogo, Stephen M. (4 March 2013). "Concomitant fungal and Mycobacterium bovis infections in beef cattle in ...
Deer
"The status of Mycobacterium bovis infection in UK wild mammals: A review". The Veterinary Journal. 164 (2): 90-105. doi:10.1053 ... In New Zealand, deer are thought to be important as vectors picking up M. bovis in areas where brushtail possums Trichosurus ...
Hypothetical protein
"In silico enzyme function prediction in hypothetical proteins of Mycobacterium bovis AF2122/97". Journal of Pharmacy Research. ...
Agriculture in Poland
Importation of alpacas infected with Mycobacterium bovis from the United Kingdom to Poland and potential for serodiagnostic ... bovis outbreak in alpacas in the country. They also were first to show that alpacas counterattack M. bovis earlier than most ... "Review of Diagnostic Tests for Detection of Mycobacterium bovis Infection in South African Wildlife". Frontiers in Veterinary ... hosts, even though the response is not always ultimately successful and M. bovis may still be fatal. This is believed to ...
Alpaca
Mycobacterium bovis also causes TB in this species worldwide. Krajewska‐Wędzina et al., 2020 detect M. bovis in individuals ... "Review of Diagnostic Tests for Detection of Mycobacterium bovis Infection in South African Wildlife". Frontiers in Veterinary ...
BCG vaccine
The vaccine was originally developed from Mycobacterium bovis, which is commonly found in cattle. While it has been weakened, ... Exposure to environmental mycobacteria (especially Mycobacterium avium, Mycobacterium marinum and Mycobacterium intracellulare ... In this study, the UK school children had a low baseline cellular immunity to mycobacteria which was increased by BCG; in ... This effect is called masking because the effect of BCG is masked by environmental mycobacteria. Clinical evidence for this ...
Listeriolysin O
Grode, L. (25 August 2005). "Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille ... A recombinant BCG vaccine against Mycobacterium tuberculosis is being developed that expresses Listeriolysin O and lacks Urease ...
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
Choi KP, Kendrick N, Daniels L (May 2002). "Demonstration that fbiC is required by Mycobacterium bovis BCG for coenzyme F(420) ...
Ovothiol A
Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis". Eur. J ...
Mycothiol synthase
Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis". ... from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases". Protein Science. 12 (9 ...
Foxhound
An outbreak of tuberculosis due to Mycobacterium bovis infection in a pack of English Foxhounds (2016-2017). Transbound Emerg ... The dogs eat raw meat and there was speculation about the diet containing the M. bovis that causes TB as the meat comes from ... areas impacted by M. bovis. In 2005, the American Kennel Club reported that the English and American Foxhounds were their least ...
Artificial cell
"Oral delivery of Mycobacterium bovis BCG in a lipid formulation induces resistance to pulmonary tuberculosis in mice". ...
Vaccine
A current example is the use of BCG vaccine made from Mycobacterium bovis to protect against tuberculosis. The subgroup of ... The live Mycobacterium tuberculosis vaccine developed by Calmette and Guérin is not made of a contagious strain but contains a ...
Mycobacterium
Mycobacteria have an outer membrane. They possess capsules, and most do not form endospores. M. marinum and perhaps M. bovis ... Mycobacteria Mycobrowser: Genomic and proteomic database for pathogenic mycobacteria CDC - Nontuberculous Mycobacteria (NTM) ... Whereas Mycobacterium tuberculosis and M. leprae are pathogenic, most mycobacteria do not cause disease unless they enter skin ... "Targeted replacement of the mycocerosic acid synthase gene in Mycobacterium bovis BCG produces a mutant that lacks mycosides". ...
Koch-Pasteur rivalry
Oettinger, T.; Jørgensen, M.; Ladefoged, A.; Hasløv, K.; Andersen, P. (1999). "Development of the Mycobacterium bovis BCG ... In 1901 at the London Congress on Tuberculosis, Koch stated on theoretical grounds that M bovis, which infects cows, was not ... British attendees disagreed, and later Theobald Smith and the English Royal Commission empirically established that M bovis was ...
Vaccine ingredients
The BCG vaccine, infant dose, contains between 100,000 and 400,000 colony-forming unit of live attenuated Mycobacterium bovis. ...
Health in Nepal
Although most common Mycobacterium species which causes tuberculosis is M. tuberculosis, TB is also caused by M. bovis and M. ... africanum and occasionally by opportunistic Mycobacteria which are: M. Kansaii, M. malmoense, M. simiae, M. szulgai, M. xenopi ... the world's most serious public health problem is an infectious bacterial disease caused by the bacillus Mycobacterium. ...
Mycocerosate synthase
Rainwater DL, Kolattukudy PE (1985). "Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin ...
BTB
Blood-testis barrier in testicular anatomy Blood-thymus barrier Bovine tuberculosis or Mycobacterium bovis, a disease ...
BioGRID
Bacillus subtilis 168 Bos taurus (cow) Caenorhabditis elegans (nematode worm) Candida albicans SC5314 Canis familiaris (dog) ... Mycobacterium tuberculosis H37Rv Mycoplasma pneumoniae M129 Neurospora crassa OR74A Nicotiana tomentosiformis Oryctolagus ...
Aspartate kinase
The main aspatokinases are lysC (Bacillus subtilis, Escherichia coli and many other bacteria), ask (Mycobacterium bovis, ...
Dairy farming in New Zealand
Mycobacterium bovis) from wild vector species across 2.5 million hectares - or one quarter - of New Zealand's at-risk areas by ... Mycoplasma bovis, a bacterial disease known to cause a range of serious conditions in cattle was detected in New Zealand in ... GERARD HUTCHING (28 May 2018). "Q&A on Mycoplasma bovis: Untangling truth from fiction of cattle disease". stuff.co.nz. ... Ministry for Primary Industries (7 June 2019). "What is Mycoplasma bovis?". MPI.govt.nz. Retrieved 19 August 2019. ...
Carcinogenic bacteria
In 1950, a Newark-based physician named Virginia Livingston published a paper claiming that a specific Mycobacterium was ... Gold JS, Bayar S, Salem RR (July 2004). "Association of Streptococcus bovis bacteremia with colonic neoplasia and extracolonic ...
Ghon's complex
In countries where cow milk infected with Mycobacterium bovis has been eliminated (due to culling of infected cows and ... pasteurization), primary tuberculosis is usually caused by Mycobacterium tuberculosis and almost always begins in the lungs. ...
Immunologic adjuvant
Mycobacterium bovis,[citation needed] toxoids Plant saponins from Quillaja (see Quil A), soybean, Polygala senega Cytokines: IL ... Freund's complete adjuvant is a solution of inactivated Mycobacterium tuberculosis in mineral oil developed in 1930. It is not ...
Common brushtail possum in New Zealand
Possums are vectors of bovine tuberculosis (Mycobacterium bovis), which is a major threat to the dairy, beef, and deer farming ... Board operates a nationwide programme of cattle testing and possum control with the goal of eradicating Mycobacterium bovis ...
Johannes Krause
Kirsten I. Bos, Verena J. Schuenemann, G. Brian Golding, Hernán A. Burbano, Nicholas Waglechner, Brian K. Coombes, Joseph B. ... "Genome-Wide Comparison of Medieval and Modern Mycobacterium leprae". Science. 341 (6142): 179-183. Bibcode:2013Sci...341..179S ... PMID 21993626.{{cite journal}}: CS1 maint: uses authors parameter (link) V. J. Schuenemann, K. Bos, S. DeWitte, S. Schmedes, J ... Bos, A. Herbig, C. Economou, A. Benjak, P. Busso, A. Nebel, J. L. Boldsen, A. Kjellström, H. Wu, G. R. Stewart, G. M. Taylor, P ...
Mycobacterium leprae
Schuenemann VJ, Singh P, Mendum TA, Krause-Kyora B, Jäger G, Bos KI, et al. (July 2013). "Genome-wide comparison of medieval ... Scholia has a topic profile for Mycobacterium leprae. The genome of Mycobacterium leprae "Mycobacterium leprae". NCBI Taxonomy ... The closest relative to Mycobacterium leprae is Mycobacterium lepromatosis. These species diverged 13.9 million years ago (95% ... tuberculosis have been lost in the Mycobacterium leprae genome.Due to Mycobacterium leprae's reliance on a host organism, many ...
CD1
Because of this and the fact that cows are a natural host of Mycobacterium bovis, a pathogen in humans as well, it is hoped ...
Buruli ulcer
Some vaccine platforms have been tested in M. ulcerans-infected mice, mostly based on the Mycobacterium bovis strain used in ... Buruli ulcer is caused by infection of the skin with the bacterium Mycobacterium ulcerans. M. ulcerans is a mycobacterium, ... It is more distantly related to other slow-growing mycobacteria that infect humans, such as Mycobacterium tuberculosis, which ... "Buruli ulcer (Mycobacterium ulcerans infection)". World Health Organization. 21 May 2019. Archived from the original on 17 ...
Thiocarlide
Isoxyl inhibits M. bovis with six hours of exposure, which is similar to isoniazid and ethionamide, two other prominent anti-TB ... December 2003). "Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis". J. Biol. Chem. 278 (52 ... has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium ...
Ancient DNA
Alan Cooper Kirsten Bos Joachim Burger M. Thomas P. Gilbert Johannes Krause Svante Pääbo Hendrik Poinar David Reich Beth ... Donoghue HD, Spigelman M, Zias J, Gernaey-Child AM, Minnikin DE (1998). "Mycobacterium tuberculosis complex DNA in calcified ...
Laura Green
She has investigated infectious diseases in cattle including Mycobacterium bovis (bovine tuberculosis), sheep (caseous ...
Mycobacterium tuberculosis
An African origin for Mycobacterium bovis. Evol Med Public Health. 2020 Jan 31;2020(1):49-59 Gagneux S, DeRiemer K, Van T, Kato ... In 2019, M. tuberculosis was found in a genetically related complex group of Mycobacterium species called Mycobacterium ... Wikimedia Commons has media related to Mycobacterium tuberculosis. Scholia has a topic profile for Mycobacterium tuberculosis. ... Bos KI, Harkins KM, Herbig A, Coscolla M, Weber N, Comas I, Forrest SA, Bryant JM, Harris SR, Schuenemann VJ, Campbell TJ, ...
European badger
Bovine tuberculosis (bovine TB) caused by Mycobacterium bovis is a major mortality factor in badgers, though infected badgers ...
Therapeutic vaccines
Bacillus Calmettle-Guerin (TheraCys) is a live attenuated vaccine which makes use of Mycobacterium bovis strain for bladder ...
Mycobacterium bovis (Bovine Tuberculosis) in Humans
M. tuberculosis). Mycobacterium bovis (M. bovis) is another mycobacterium that can cause TB disease in people. M. bovis is most ... Mycobacterium bovis (Bovine Tuberculosis) in Humans What is Mycobacterium bovis? In the United States, the majority of ... How do I know if Ive been infected with M. bovis?. Most people are at very low risk for being infected with M. bovis. People ... How can M. bovis infection be prevented?. The most commonly reported source of M. bovis infection in people is the consumption ...
Parcourir par sujet "MYCOBACTERIUM BOVIS"
Report of the WHO Meeting on Zoonotic Tuberculosis (Mycobacterium bovis, Geneva, 15 November 1993 / with the participation of ... Report of the WHO working group on zoonotic tuberculosis (Mycobacterium bovis, Mainz, Germany, 14 June 1994 / with the ... WHO Working Group on Zoonotic Tuberculosis (Mycobacterium bovis) 1994: Mainz, Germany); World Health Organization. ... Guidelines for speciation within the Mycobacterium tuberculosis complex / John M. Grange, Malcolm D. Yates and Isabel N. de ...
RRC: Mycobacterium bovis in a free-ranging black rhinoceros, Kruger National Park, South Africa, 2016
RRC: Novel assays for detection of mycobacterium bovis infecti...
Disease Risk Assessment of Mycobacterium bovis in African Lions - AAZV2011 - VIN
In 1995, lions in Kruger National Park were discovered to be infected with Mycobacterium bovis (bovine tuberculosis), a non- ... It is therefore likely that lions are a spill-over species for M. bovis and that the prevalence and spread of M. bovis in ... bovis transmission in Krugers lion population. We varied M. bovis transmission rates from buffalo to lion, from mother to cub ... The model suggests that transmission of M. bovis from buffalo to lions dominates the spread of bovine tuberculosis in Kruger ...
SciELO - Brazil - Avaliação do tratamento com isoniazida em bovinos infectados naturalmente pelo Mycobacterium bovis Avaliação...
AID 1664578 - Antitubercular activity against Mycobacterium bovis BCG assessed as bacterial growth inhibition at 10 ug/ml by...
Activity of 5-chloro-pyrazinamide in mice infected with Mycobacterium tuberculosis or Mycobacterium bovis - Fingerprint
-...
Immunohistochemical characterization of tuberculous lesions in sheep naturally infected with Mycobacterium bovis | BMC...
... developed being attracted to the lesions in a shift towards a Th2 response against the increasing amounts of mycobacteria. ... Sheep have been traditionally considered as less susceptible to Mycobacterium bovis (Mbovis) infection than other domestic ... Upregulation of IL-17A, CXCL9 and CXCL10 in early-stage granulomas induced by Mycobacterium bovis in cattle. Transbound Emerg ... Mycobacterium bovis infections in domesticated non-bovine mammalian species. Part 1: Review of epidemiology and laboratory ...
Human Tuberculosis Caused by Mycobacterium bovis, Taiwan
Title : Human Tuberculosis Caused by Mycobacterium bovis, Taiwan Personal Author(s) : Jou, Ruwen;Huang, Wei-Lun;Chiang, Chen- ... Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009-2015 Cite ... Title : Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009-2015 Personal Author(s ...
Infection of Mice with Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) Suppresses Allergen-induced Airway Eosinophilia |...
Infection of Mice with Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) Suppresses Allergen-induced Airway Eosinophilia Klaus ... Klaus Josef Erb, John W. Holloway, Alexandra Sobeck, Heidrun Moll, Graham Le Gros; Infection of Mice with Mycobacterium bovis- ... In this report we address the question of whether an infection with an attenuated form of Mycobacterium bovis, Bacillus ... We have investigated this issue by combining an intranasal Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) infection with a ...
Antibody prevalence to African swine fever virus, Mycobacterium bovis, foot-and-mouth disease virus, Rift Valley fever virus,...
Higher prevalence of antibodies to African swine fever virus and Mycobacterium bovis were detected in warthogs from the Greater ... Antibody prevalence to African swine fever virus, Mycobacterium bovis, foot-and-mouth disease virus, Rift Valley fever virus, ... Antibody prevalence to African swine fever virus, Mycobacterium bovis, foot-and-mouth disease virus, Rift Valley fever virus, ... At the univariate analysis, M. bovis seropositivity was significantly different among age categories, with 49% (35/71) of ...
Real-time PCR using atpE, conventional PCR targeting different regions of difference, and flow cytometry for confirmation of...
... bovis was 25/54 (46.3%). Real-time PCR using atpE was positive for mycobacteria on the genus level in 18/18 (100%) and 5/5 (100 ... The skin test suffers from interference from non-tuberculous mycobacteria able to cause false-positive reactions in cattle and ... bovis isolation, real-time and simplex PCR, and flow Cytometry. The tuberculin test is the reference test in Egypt, the ... of tissue samples and isolates, respectively; simplex PCR detected M. bovis in 44/54 (81.5%) and 25/25 (100%) of tissue samples ...
Inhibition of phago-lysosome fusion and foam cell formation by Mycobacterium bovis BCG induces a Niemann-Pick type C1 like...
Genome-wide estimation of recombination, mutation and positive selection enlightens diversification drivers of Mycobacterium...
Mycobacterium tuberculosis complex (MTBC), enclosing M. bovis as one of its animal-adapted members causing tuberculosis (TB) in ... mutation and positive selection enlightens diversification drivers of Mycobacterium bovis. * Articles in SCI Journals ... mutation and positive selection enlightens diversification drivers of Mycobacterium bovis. ... Based on this work, recombination in M. bovis cannot be excluded and should thus be a topic of further effort in future ...
Impaired protection against Mycobacterium bovis bacillus Calmette-Guérin infection in IL-15-deficient mice<...
Impaired protection against Mycobacterium bovis bacillus Calmette-Guérin infection in IL-15-deficient mice」の研究トピックを掘り下げます。これらがま ... Impaired protection against Mycobacterium bovis bacillus Calmette-Guérin infection in IL-15-deficient mice. In: Journal of ... Impaired protection against Mycobacterium bovis bacillus Calmette-Guérin infection in IL-15-deficient mice. Journal of ... Impaired protection against Mycobacterium bovis bacillus Calmette-Guérin infection in IL-15-deficient mice. / Saito, Kimika
Adaptation and Diagnostic Potential of a Commercial Cat Interferon Gamma Release Assay for the Detection of Mycobacterium bovis...
Adaptation and Diagnostic Potential of a Commercial Cat Interferon Gamma Release Assay for the Detection of Mycobacterium bovis ... Adaptation and Diagnostic Potential of a Commercial Cat Interferon Gamma Release Assay for the Detection of Mycobacterium bovis ... Adaptation and Diagnostic Potential of a Commercial Cat Interferon Gamma Release Assay for the Detection of Mycobacterium bovis ...
Phosphate starvation enhances phagocytosis of Mycobacterium bovis/BCG by macrophages | BMC Immunology | Full Text
The only available vaccine is M. bovis/BCG, an attenuated mycobacterium that activates the innate and the acquired immune ... In this study we showed that macrophages phagocytose M. bovis/BCG bacilli with higher efficiency when they are cultured without ... The interest of our observations is to show that under the metabolic stress implied in phosphate deprivation, mycobacteria ... These observations are relevant to understand how M. bovis/BCG induces protective immunity. ...
Mycobacterium bovis Positive Extraction Control - Innovative Diagnostics
Mycobacterium bovis (BCG kas(B)) | The Antimicrobial Index Knowledgebase - TOKU-E
Mycobacterium bovis (BCG kas(B)) antimicrobial susceptibility data. ... Mycobacterium bovis (BCG + kas(B)). -. -. 0.2 - ?. Cerulenin 415. Mycobacterium bovis (BCG + kas(B)). -. -. 0.25 - ?. Isoxyl ( ... Mycobacterium bovis (BCG + kas(B)). -. -. 2 - ?. Ethionamide (Trecator). 415. Mycobacterium bovis (BCG + kas(B)). -. -. 100 - ? ... Mycobacterium bovis (BCG + kas(B)). -. -. 0.05 - ?. Isoniazid (INH, Laniazid, Nydrazid, Rifamate). 415. ...
The 16-kDa α-crystallin-like protein of Mycobacterium bovis BCG is produced under conditions of oxygen deficiency and is...
keywords = "BCG, Mycobacterium bovis, O deficiency, O; α-crystallin-like stress protein, Ribosomal binding protein, Ribosome", ... Dive into the research topics of The 16-kDa α-crystallin-like protein of Mycobacterium bovis BCG is produced under conditions ... T1 - The 16-kDa α-crystallin-like protein of Mycobacterium bovis BCG is produced under conditions of oxygen deficiency and is ... The 16-kDa α-crystallin-like protein of Mycobacterium bovis BCG is produced under conditions of oxygen deficiency and is ...
Natural variation in immune responses to neonatal mycobacterium bovis bacillus calmette-guerin (BCG) vaccination in a cohort of...
Natural variation in immune responses to neonatal mycobacterium bovis bacillus calmette-guerin (BCG) vaccination in a cohort of ... Natural variation in immune responses to neonatal mycobacterium bovis bacillus calmette-guerin (BCG) vaccination in a cohort of ... Interferon-gamma (IFN-) is required for immunity to mycobacteria and used as a marker of immunity when new vaccines are tested ... Methodology/Principal Findings 236 healthy Gambian babies were vaccinated with M. bovis BCG at birth. IFN-, interleukin (IL)-5 ...
Inhibition of phago-lysosome fusion and foam cell formation by Mycobacterium bovis BCG induces a Niemann-Pick type C1 like...
Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis. - Immunology
Protection was determined by measuring development of disease as an end point after M. bovis challenge. Either Ad85A or MVA85A ... of tuberculosis has shown that vaccination strategies based on heterologous prime-boost protocols using Mycobacterium bovis ... Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis. ... Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis. ...
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Open [email protected]: Cloning and sequencing of the SECY gene homolog from Mycobacterium bovis BCG
Cloning and sequencing of the SECY gene homolog from Mycobacterium bovis BCG. Author(s). Jin Koo Kim; Jeong Hyun Kim; Sang Jae ... The complete nucleotide sequence of a 1513 bp fragment of Mycobacterium bovis BCG containing the secY gene homolog and partial ... Cloning and sequencing of the SECY gene homolog from Mycobacterium bovis BCG. ...
IMSEAR at SEARO: Isolation of Mycobacterium bovis & M. tuberculosis from cattle of some farms in north India--possible...
Isolation of Mycobacterium bovis & M. tuberculosis from cattle of some farms in north India--possible relevance in human health ... Isolation of Mycobacterium bovis & M. tuberculosis from cattle of some farms in north India--possible relevance in human health ... M. bovis in milk indicates the need to investigate the transmission to human in such settings. Isolation of M. bovis and/or M. ... M. bovis [6/40(15%)] and M. tuberculosis [4/14(28.5%)] were also isolated from milk. Only 3/40 (7.5%) isolates of M.bovis could ...
BovineNaturally infected with Mycobacterium bovisInfectionBacteriaBacillusAviumStrainsCattleInfectionsPathogenKilled Mycobacterium tuberculosisPrevalenceCapraeHumansLepraeIsolates were identifiedAfricanumAbstractComplexSpeciesMycobacterialTuberculosis casesInducesOrganismsBacilliVaccineLineagesDetectionMilkImmunityStrainImmune ResponseLesionsFlavescensInfectCervicalOccursExposureDiseaseMutationMedicine
Bovine9
- In 1995, lions in Kruger National Park were discovered to be infected with Mycobacterium bovis (bovine tuberculosis), a non-endemic disease maintained by the park's buffalo. (vin.com)
- The model suggests that transmission of M. bovis from buffalo to lions dominates the spread of bovine tuberculosis in Kruger National Park. (vin.com)
- Mycobacterium bovis is a serious pathogen that causes chronic bovine tuberculosis (TB). (biomedcentral.com)
- Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis. (ox.ac.uk)
- Spatial perturbation caused by a badger ( Meles meles ) culling operation: implications for the function of territoriality and the control of bovine tuberculosis ( Mycobacterium bovis ). (wildcru.org)
- Bovine tuberculosis is among the primary zoonotic disease caused by Mycobacterium bovis which has significant impact on the health of livestock and human. (biomedcentral.com)
- Bovine tuberculosis is a common zoonotic disease caused by Mycobacterium bovis which affects a wide range of animals and humans [ 2 , 3 ]. (biomedcentral.com)
- This fact sheet describes Mycobacterium bovis (bovine tuberculosis) in humans. (cdc.gov)
- Bovine tuberculosis (BTB) attributable to Mycobacterium bovis stays a serious downside in each the developed and growing international locations. (europeanvaccinesdiagnostics.com)
Naturally infected with Mycobacterium bovis1
- The prevalence, distribution and severity of detectable pathological lesions in badgers naturally infected with Mycobacterium bovis. (ox.ac.uk)
Infection18
- Infection can also occur from direct contact with a wound, such as what might occur during slaughter or hunting, or by inhaling the bacteria in air exhaled by animals infected with M. bovis. (cdc.gov)
- People who might be at higher risk of M. bovis infection should talk to their healthcare providers about whether they should be regularly screened for TB infection. (cdc.gov)
- No. The Cooperative State-Federal Tuberculosis Eradication Program, including the U.S. Department of Agriculture, state animal health agencies, and U.S. livestock producers, has nearly eliminated M. bovis infection from cattle in the United States. (cdc.gov)
- Cattle outside the United States, particularly in developing countries, might not have the same level of inspection for M. bovis infection. (cdc.gov)
- How can M. bovis infection be prevented? (cdc.gov)
- The most commonly reported source of M. bovis infection in people is the consumption of unpasteurized dairy products. (cdc.gov)
- Novel assays for detection of mycobacterium bovis infection in free-ranging african rhinoceros (Diceros bicornis, Ceratotherium simum) and implications for conservation. (rhinoresourcecenter.com)
- Sheep have been traditionally considered as less susceptible to Mycobacterium bovis (Mbovis) infection than other domestic ruminants such as cattle and goats. (biomedcentral.com)
- We have investigated this issue by combining an intranasal Mycobacterium bovis -Bacillus Calmette-Guérin (BCG) infection with a murine model of allergen, (ovalbumin [OVA]) induced airway eosinophilia. (rupress.org)
- To investigate the potential role of endogenous IL-15 in mycobacterial infection, we examined protective immunity in IL-15-deficient (IL-15 -/- ) mice after infection with Mycobacterium bovis bacillus Calmette-Guérin (BCG) or recombinant OVA-expressing BCG (rBCG-OVA). (elsevier.com)
- BACKGROUND & OBJECTIVE: Infection due to Mycobacterium bovis typically occurs in cattle and animals transmit infection to each other. (who.int)
- Isolation of M. bovis and/or M. tuberculosis from apparently healthy cattle indicates sub-clinical infection in the herd. (who.int)
- Under the hypothesis that the oral route could be playing a more relevant role in transmission, diagnosis and disease persistence than previously thought, this study was performed to assess the course of TB infection in cattle and its effects on diagnosis depending on the route of entry of Mycobacterium bovis . (biomedcentral.com)
- Oral exposure to M . bovis could represent a more relevant route of infection than previously thought. (biomedcentral.com)
- Malkin J, Shrimpton A, Wiselka M, Barer MR, Duddridge M, Perera N. Olecranon bursitis secondary to Mycobacterium kansasii infection in a patient receiving infliximab for Behcet's disease. (medscape.com)
- Histopathology of Disseminated Mycobacterium bovis Infection Complicating Intravesical BCG Immunotherapy for Urothelial Carcinoma. (medscape.com)
- Specific Recognition of Mycobacterial Protein and Peptide Antigens by γδ T Cell Subsets following Infection with Virulent Mycobacterium bovis. (umass.edu)
- So, long way to say that we've been doing this a long time and any infection caused by M. tuberculosis , be it in humans or in animals--elephants, lions, elk, and also in cows, which is caused by related bacteria, M. bovis --we can fingerprint. (cdc.gov)
Bacteria4
- The granuloma is capable of limiting growth of mycobacteria but also is a good environment from which the bacteria may disseminate [ 5 ]. (biomedcentral.com)
- TB is caused by bacteria (germs) called Mycobacterium tuberculosis. (medlineplus.gov)
- Bacteria: Mycobacterium avium ssp. (credoreference.com)
- Contact with different species of environmental Mycobacterium can cause acquired immunity to M. tuberculosis or increase the efficacy of BCG vaccine protection (M. vaccae, M. microti), although some species of these bacteria reduce the efficacy of BCG vaccine (M. scrofulaceum) [8,10-13]. (who.int)
Bacillus1
- Previous work with small-animal laboratory models of tuberculosis has shown that vaccination strategies based on heterologous prime-boost protocols using Mycobacterium bovis bacillus Calmette-Guérin (BCG) to prime and modified vaccinia virus Ankara strain (MVA85A) or recombinant attenuated adenoviruses (Ad85A) expressing the mycobacterial antigen Ag85A to boost may increase the protective efficacy of BCG. (ox.ac.uk)
Avium3
- Draft genome sequences of two Bison-type and two Sheep-type strains of Mycobacterium avium subspecies paratuberculosis. (usda.gov)
- Complete genome sequence of a type III ovine strain of Mycobacterium avium subspecies paratuberculosis. (usda.gov)
- LAMP technology: Rapid identification of Brucella and Mycobacterium avium subsp. (gob.ar)
Strains5
- The treatment in this herd did not cause selection of isoniazid-resistant strains as demonstrated by the isoniazid sensitivity test carried out in M. bovis culture isolated from a non-cured animal. (scielo.br)
- In addition, the emergence of MDR-TB in recent years has raised special concerns in relation to the international spread of particularly dangerous strains of Mycobacterium tuberculosis . (who.int)
- Analysis of restriction fragment length polymorphism (RFLP) of Mycobacterium tuberculosis strains isolated from patients with several episodes of tuberculosis]. (nih.gov)
- The emergence of MdR-TB and extensively drug-resistant TB (XdR-TB) has raised special concerns in relation to the international spread of par- ticularly dangerous strains of Mycobacterium tuberculosis . (bvsalud.org)
- These proteins, (ESAT-6 and CFP-10) are absent from all BCG strains and from most non-tuberculous mycobacteria with the exception of M. kansasii, M. szulgai and M. marinum. (cdc.gov)
Cattle11
- M. bovis is most commonly found in cattle and other animals such as bison, elk, and deer. (cdc.gov)
- M. bovis transmission from cattle to people was once common in the United States. (cdc.gov)
- Are all cattle infected with M. bovis? (cdc.gov)
- Although information from many M. bovis , and cattle are the major reservoir ( 2 , 3 ). (cdc.gov)
- In this study, 1500 buffaloes and 2200 cattle were tested by single intradermal comparative cervical tuberculin test and compared with the detection rates of M. bovis isolation, real-time and simplex PCR, and flow Cytometry. (biomedcentral.com)
- The skin test suffers from interference from non-tuberculous mycobacteria able to cause false-positive reactions in cattle and other species. (biomedcentral.com)
- IMSEAR at SEARO: Isolation of Mycobacterium bovis & M. tuberculosis from cattle of some farms in north India--possible relevance in human health. (who.int)
- The choice of appropriate clinical specimen is very important for isolation of M. bovis and M. tuberculosis from cattle. (who.int)
- The present study reports the isolation of M. tuberculosis and M. bovis from different types of specimens from cattle suspected to be suffering from tuberculosis in certain organized cattle farms in north India. (who.int)
- Twenty-eight cattle, sensitized by injection of heat-killed Mycobacterium bovis, were used. (usda.gov)
- In developed countries, the occurrence of human tuberculosis due to M. bovis has meaningfully declined because of mandatory pasteurization of milk together with tuberculin skin testing of cattle followed by culling/slaughtering the infected cattle [ 8 ]. (biomedcentral.com)
Infections3
- Not all M. bovis infections progress to TB disease, so there might be no symptoms at all. (cdc.gov)
- Mycobacterium bovis notoriously causes detrimental infections in bovines and humans. (biomedcentral.com)
- Infections with Mycobacterium bovis or atypical Mycobacterium species have been reported. (medscape.com)
Pathogen3
- As other MTBC members, M. bovis is postulated as a strictly clonal, slowly evolving pathogen, with apparently no signs of recombination or horizontal gene transfer. (ulisboa.pt)
- A closer look on genes prone to horizontal gene transfer in the MTBC ancestor and included in the 3R (DNA repair, replication and recombination) system revealed a global average negative value for Taijima's D neutrality test, suggesting that past selective sweeps and population expansion after a recent bottleneck remain as major evolutionary drivers of the obligatory pathogen M. bovis in its struggle with the host. (ulisboa.pt)
- CONCLUSION: Based on these findings, it is imperative that M. bovis be considered as a pathogen of concern to people living in rural areas of Tanzania. (ac.tz)
Killed Mycobacterium tuberculosis1
- IFN-, interleukin (IL)-5 and IL-13 responses to purified protein derivative (PPD), killed Mycobacterium tuberculosis (KMTB), M. tuberculosis short term culture filtrate (STCF) and M. bovis BCG antigen 85 complex (Ag85) were measured in a whole blood assay two months after vaccination. (sussex.ac.uk)
Prevalence5
- It is therefore likely that lions are a spill-over species for M. bovis and that the prevalence and spread of M. bovis in buffalos will be the biggest predictor of prevalence and spread of M. bovis in the lion population. (vin.com)
- Antibody prevalence to African swine fever virus, Mycobacterium bovis, foot-and-mouth disease virus, Rift Valley fever virus, influenza A virus, and Brucella and Leptospira spp. (up.ac.za)
- Higher prevalence of antibodies to African swine fever virus and Mycobacterium bovis were detected in warthogs from the Greater Kruger National Park ecosystem in comparison to lower prevalence of antibodies to M. bovis and no antibodies to African swine fever virus in warthogs from uMhkuze Game Reserve. (up.ac.za)
- ABSTRACT This research compared the numbers and types of different Mycobacterium species in soil samples taken from 2 areas of Golestan province, Islamic Republic of Iran, 1 with a high prevalence of tuberculosis and 1 with a low prevalence. (who.int)
- The frequencies of environmental Mycobacterium in the low-prevalence area were much higher than in the high-prevalence area, perhaps due to different environmental factors. (who.int)
Caprae3
- 1.4% in connection with overall TB in- M. bovis or M. caprae . (cdc.gov)
- M. tuberculosis , M. africanum , M. canettii , M. bovis , M. caprae , M. pinnipedii , M. microti , and M. mungi ( 1 - 4 ). (cdc.gov)
- The deleted region for RD12 (RD12 oryx ) was larger than that for M. bovis and M. caprae . (cdc.gov)
Humans2
- Direct transmission from animals to humans through the air is thought to be rare, but M. bovis can be spread directly from person to person when people with the disease in their lungs cough or sneeze. (cdc.gov)
- The microbe Mycobacterium tuberculosis (MTB) is an ancient cohabiter with humans, infecting almost 3 billion people worldwide, 10% of them developing clinical disease. (intechopen.com)
Leprae1
- There are currently 71 recognized or proposed species of Mycobacterium [1], all of which, except M. tuberculosis complex and M. leprae, are considered as environmental mycobacteria and can usually be isolated from environmental samples including water, soil and dust [2]. (who.int)
Isolates were identified2
- The culture isolates were identified as M. tuberculosis and M. bovis on the basis of biochemical tests. (who.int)
- Mycobacteria isolates were identified by morphological features, PCR-Restriction Fragment Length Polymorphism Analysis (PCR-PRA) and Mycolic acids analysis. (academicoo.com)
Africanum1
- Individuals infected with M. tuberculosis complex organisms (M. tuberculosis, M. bovis, M. africanum, M. microti, M. canetti) usually have lymphocytes in their blood that recognize these and other mycobacterial antigens. (cdc.gov)
Abstract1
- abstract = "A 16-kDa protein, identical to the α-crystallin-like stress protein, was induced under O2-deficient culture conditions and bound principally to the 30S ribosomal subunits of Mycobacterium bovis BCG substrain Tokyo (BCG). (elsevier.com)
Complex5
- We analyzed 98 Mycobacterium tuberculosis complex platform to enhance SARS-CoV-2 testing capacity. (cdc.gov)
- Mycobacterium tuberculosis complex (MTBC), enclosing M. bovis as one of its animal-adapted members causing tuberculosis (TB) in terrestrial mammals, is a paradigmatic model of bacterial evolution. (ulisboa.pt)
- RESULTS: A total of 54 M. tuberculosis complex isolates were obtained, of them 40 were identified as M.bovis and 14 as M. tuberculosis. (who.int)
- In 2008, a total of 94 (10.7%) isolates of Mycobacterium tuberculosis complex were resistant to at least one of the anti-tuberculosis agents. (health.gov.au)
- The oryx bacilli are Mycobacterium tuberculosis complex organisms for which phylogenetic position and host range are unsettled. (cdc.gov)
Species3
- The differential r/m average values obtained across the clonal complexes of M. bovis in our dataset are consistent with the general notion that the extent of recombination may vary widely among lineages assigned to the same taxonomical species. (ulisboa.pt)
- RESULTS: Overall, 31 (70.5%) of the mycobacterialisolates recovered from all forms of tuberculosis were identified as M. tuberculosis, seven (16.0%) were identified as M. bovis, and six (13.6%) were other mycobacterial species. (ac.tz)
- The most common species isolated were Mycobacterium fortuitum, M. flavescens and M. chelonae. (who.int)
Mycobacterial1
- we found that together with PstS-1, the membranes of Pi-deprived mycobacteria express the mycobacterial adhesins LpqH, LprG, and the APA antigen, glycoproteins that are not directly involved in phosphate regulation. (biomedcentral.com)
Tuberculosis cases2
- OBJECTIVES: To determine the involvement of Mycobacterium bovis in tuberculosis cases presenting at tuberculosis (TB) clinics in rural areas in these zones. (ac.tz)
- This report prepared by the Australian Mycobacterium Reference Laboratory Network provides an analysis of tuberculosis cases in 2008 and 2009, which were bacteriologically confirmed. (health.gov.au)
Induces1
- These observations are relevant to understand how M. bovis/ BCG induces protective immunity. (biomedcentral.com)
Organisms1
- The pasteurization process, which destroys disease-causing organisms in milk by rapidly heating and then cooling the milk, eliminates M. bovis from milk products. (cdc.gov)
Bacilli4
- In this study we showed that macrophages phagocytose M. bovis /BCG bacilli with higher efficiency when they are cultured without phosphate. (biomedcentral.com)
- After phagocytosis, mycobacteria can be lysed within the phagolysosome, although virulent bacilli have developed the ability to avoid destruction impeding the fusion of the phagosome with the lysosome, thus transforming the MO in a friendly niche where they proliferate and persist [ 2 , 4 ]. (biomedcentral.com)
- Herein, we show that M. bovis /BCG bacilli grown without phosphate are engulfed with increased efficiency by MO, an event that was associated with decreased phagosome acidification. (biomedcentral.com)
- Immunofluorescence microscopy revealed that the number of MOs with engulfed or bound bacilli was significantly higher with Pi-deprived mycobacteria (Fig. 1 a, b). (biomedcentral.com)
Vaccine3
- The only available vaccine is M. bovis/BCG , an attenuated mycobacterium that activates the innate and the acquired immune system after being phagocytosed by macrophages and dendritic cells. (biomedcentral.com)
- Freeze-dried preparation of inactivated Mycobacterium bovis BCG-Copenhagen vaccine strain (ATCC-27290) diluted in a negative lymph node supernatant. (innovative-diagnostics.com)
- This liquid drug is made from a strain of Mycobacterium bovis - the same bacterium used to create the tuberculosis vaccine. (clevelandclinic.org)
Lineages1
- In this work, we applied comparative genomics to a whole genome sequence (WGS) dataset composed by 70 M. bovis from different lineages (European and African) to gain insights into the evolutionary forces that shape genetic diversification in M. bovis . (ulisboa.pt)
Detection1
- RRC: Novel assays for detection of mycobacterium bovis infecti. (rhinoresourcecenter.com)
Milk3
- M. bovis [6/40(15%)] and M. tuberculosis [4/14(28.5%)] were also isolated from milk. (who.int)
- M. bovis in milk indicates the need to investigate the transmission to human in such settings. (who.int)
- Studies showed that BTB is still common in these developing countries where routine milk pasteurization is not practiced, and an estimated 10-15% of human tuberculosis incidences are because of M. bovis [ 10 , 11 ]. (biomedcentral.com)
Immunity1
- Interferon-gamma (IFN-) is required for immunity to mycobacteria and used as a marker of immunity when new vaccines are tested. (sussex.ac.uk)
Strain1
- A smaller M. bovis dataset (n = 42) from a multi-host TB endemic scenario was then subjected to additional analyses, with the identification of more than 1,800 sites wherein at least one strain showed a single nucleotide polymorphism (SNP). (ulisboa.pt)
Immune Response1
- Another reason for the medical importance of environmental Mycobacterium is the potential impact on the immune response. (who.int)
Lesions1
- Plasma cells and mainly B lymphocytes increased considerably as the granuloma developed being attracted to the lesions in a shift towards a Th2 response against the increasing amounts of mycobacteria. (biomedcentral.com)
Flavescens1
- Les espèces les plus couramment isolées étaient Mycobacterium fortuitum, M. flavescens et M. chelonae. (who.int)
Infect1
- The interest of our observations is to show that under the metabolic stress implied in phosphate deprivation, mycobacteria respond upregulating adhesins that could improve their capacity to infect macrophages. (biomedcentral.com)
Cervical1
- Isolation of Mycobacterium bovis from human cases of cervical adenitis in Tanzania: A cause for concern? (ac.tz)
Occurs1
- Burnout syndrome (BOS) occurs in all types of health-care professionals and is especially common in individuals who care for critically ill patients. (lookformedical.com)
Exposure1
- These include direct or indirect inhalation, oropharyngeal exposure and/or ingestion of M. bovis and, more unlikely because of the active eradication programs, transplacental or mammary transmission [ 17 ]. (biomedcentral.com)
Disease5
- Mycobacterium bovis (M. bovis) is another mycobacterium that can cause TB disease in people. (cdc.gov)
- How common is human disease with M. bovis? (cdc.gov)
- 2 We merged a stochastic, spatial, individually-based lion simulation model with a disease model to investigate the relative importance of different modes of M. bovis transmission in Kruger's lion population. (vin.com)
- Protection was determined by measuring development of disease as an end point after M. bovis challenge. (ox.ac.uk)
- Investigation of M. bovis both in animal and human population still leftover low in such underdeveloped regions particularly in Africa despite the disease remains a possible health risk. (biomedcentral.com)
Mutation1
- Still, recombination reveals a weaker effect on M. bovis diversity compared with mutation (overall r/m = 0.037). (ulisboa.pt)
Medicine1
- When used in medicine, Mycobacterium bovis is weakened to reduce harm to your body. (clevelandclinic.org)