Muscular Dystrophy, Duchenne
An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.
Neuromuscular disorder characterized by PROGRESSIVE MUSCULAR ATROPHY; MYOTONIA, and various multisystem atrophies. Mild INTELLECTUAL DISABILITY may also occur. Abnormal TRINUCLEOTIDE REPEAT EXPANSION in the 3' UNTRANSLATED REGIONS of DMPK PROTEIN gene is associated with Myotonic Dystrophy 1. DNA REPEAT EXPANSION of zinc finger protein-9 gene intron is associated with Myotonic Dystrophy 2.
Muscular Dystrophies, Limb-Girdle
A heterogenous group of inherited muscular dystrophy that can be autosomal dominant or autosomal recessive. There are many forms (called LGMDs) involving genes encoding muscle membrane proteins such as the sarcoglycan (SARCOGLYCANS) complex that interacts with DYSTROPHIN. The disease is characterized by progressing wasting and weakness of the proximal muscles of arms and legs around the HIPS and SHOULDERS (the pelvic and shoulder girdles).
Muscular Dystrophy, Facioscapulohumeral
An autosomal dominant degenerative muscle disease characterized by slowly progressive weakness of the muscles of the face, upper-arm, and shoulder girdle. The onset of symptoms usually occurs in the first or second decade of life. Affected individuals usually present with impairment of upper extremity elevation. This tends to be followed by facial weakness, primarily involving the orbicularis oris and orbicularis oculi muscles. (Neuromuscul Disord 1997;7(1):55-62; Adams et al., Principles of Neurology, 6th ed, p1420)
Mice, Inbred mdx
A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.
Muscular Dystrophy, Emery-Dreifuss
A heterogenous group of inherited muscular dystrophy without the involvement of nervous system. The disease is characterized by MUSCULAR ATROPHY; MUSCLE WEAKNESS; CONTRACTURE of the elbows; ACHILLES TENDON; and posterior cervical muscles; with or without cardiac features. There are several INHERITANCE PATTERNS including X-linked (X CHROMOSOME), autosomal dominant, and autosomal recessive gene mutations.
Corneal Dystrophies, Hereditary
Muscular Dystrophy, Oculopharyngeal
Fuchs' Endothelial Dystrophy
Two closely related polypeptides (molecular weight 7,000) isolated from the thymus gland. These hormones induce the differentiation of prothymocytes to thymocytes within the thymus. They also cause a delayed impairment of neuromuscular transmission in vivo and are therefore believed to be the agent responsible for myasthenia gravis.
Collagen Type VI
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Muscle Fibers, Skeletal
Large, multinucleate single cells, either cylindrical or prismatic in shape, that form the basic unit of SKELETAL MUSCLE. They consist of MYOFIBRILS enclosed within and attached to the SARCOLEMMA. They are derived from the fusion of skeletal myoblasts (MYOBLASTS, SKELETAL) into a syncytium, followed by differentiation.
Chromosomes, Human, Pair 4
Lamin Type A
Dystrophin-Associated Protein Complex
Poly(A)-Binding Protein II
A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
A nonspecific term referring both to the pathologic finding of swelling of distal portions of axons in the brain and to disorders which feature this finding. Neuroaxonal dystrophy is seen in various genetic diseases, vitamin deficiencies, and aging. Infantile neuroaxonal dystrophy is an autosomal recessive disease characterized by arrested psychomotor development at 6 months to 2 years of age, ataxia, brain stem dysfunction, and quadriparesis. Juvenile and adult forms also occur. Pathologic findings include brain atrophy and widespread accumulation of axonal spheroids throughout the neuroaxis, peripheral nerves, and dental pulp. (From Davis & Robertson, Textbook of Neuropathology, 2nd ed, p927)
Disease Models, Animal
Rare autosomal recessive lissencephaly type 2 associated with congenital MUSCULAR DYSTROPHY and eye anomalies (e.g., RETINAL DETACHMENT; CATARACT; MICROPHTHALMOS). It is often associated with additional brain malformations such as HYDROCEPHALY and cerebellar hypoplasia and is the most severe form of the group of related syndromes (alpha-dystroglycanopathies) with common congenital abnormalities in the brain, eye and muscle development.
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 220.127.116.11.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
A cytoskeletal linker protein with a molecular weight of greater than 500 kDa. It binds INTERMEDIATE FILAMENTS; MICROTUBULES; and ACTIN CYTOSKELETON and plays a central role in the organization and stability of the CYTOSKELETON. Plectin is phosphorylated by CALMODULIN KINASE; PROTEIN KINASE A; and PROTEIN KINASE C.
A giant elastic protein of molecular mass ranging from 2,993 kDa (cardiac), 3,300 kDa (psoas), to 3,700 kDa (soleus) having a kinase domain. The amino- terminal is involved in a Z line binding, and the carboxy-terminal region is bound to the myosin filament with an overlap between the counter-connectin filaments at the M line.
Reflex Sympathetic Dystrophy
A syndrome characterized by severe burning pain in an extremity accompanied by sudomotor, vasomotor, and trophic changes in bone without an associated specific nerve injury. This condition is most often precipitated by trauma to soft tissue or nerve complexes. The skin over the affected region is usually erythematous and demonstrates hypersensitivity to tactile stimuli and erythema. (Adams et al., Principles of Neurology, 6th ed, p1360; Pain 1995 Oct;63(1):127-33)
A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)
Vitelliform Macular Dystrophy
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Satellite Cells, Skeletal Muscle
Trinucleotide Repeat Expansion
An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.
Mature contractile cells, commonly known as myocytes, that form one of three kinds of muscle. The three types of muscle cells are skeletal (MUSCLE FIBERS, SKELETAL), cardiac (MYOCYTES, CARDIAC), and smooth (MYOCYTES, SMOOTH MUSCLE). They are derived from embryonic (precursor) muscle cells called MYOBLASTS.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
Poly(A)-Binding Protein I
A poly(A) binding protein that has a variety of functions such as mRNA stabilization and protection of RNA from nuclease activity. Although poly(A) binding protein I is considered a major cytoplasmic RNA-binding protein it is also found in the CELL NUCLEUS and may be involved in transport of mRNP particles.
An educational process that provides information and advice to individuals or families about a genetic condition that may affect them. The purpose is to help individuals make informed decisions about marriage, reproduction, and other health management issues based on information about the genetic disease, the available diagnostic tests, and management programs. Psychosocial support is usually offered.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously.
Integrin alpha Chains
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
Amino Acid Sequence
Age of Onset
Epidermolysis Bullosa Simplex
Gene Expression Regulation
Agents that have a damaging effect on the HEART. Such damage can occur from ALKYLATING AGENTS; FREE RADICALS; or metabolites from OXIDATIVE STRESS and in some cases is countered by CARDIOTONIC AGENTS. Induction of LONG QT SYNDROME or TORSADES DE POINTES has been the reason for viewing some drugs as cardiotoxins.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Nitric Oxide Synthase Type I
Enzymes that catalyze the transfer of glycosyl groups to an acceptor. Most often another carbohydrate molecule acts as an acceptor, but inorganic phosphate can also act as an acceptor, such as in the case of PHOSPHORYLASES. Some of the enzymes in this group also catalyze hydrolysis, which can be regarded as transfer of a glycosyl group from the donor to water. Subclasses include the HEXOSYLTRANSFERASES; PENTOSYLTRANSFERASES; SIALYLTRANSFERASES; and those transferring other glycosyl groups. EC 2.4.
Tandem Repeat Sequences
Corneal Dystrophy, Juvenile Epithelial of Meesmann
The attempt to improve the PHENOTYPES of future generations of the human population by fostering the reproduction of those with favorable phenotypes and GENOTYPES and hampering or preventing BREEDING by those with "undesirable" phenotypes and genotypes. The concept is largely discredited. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Collagen Type VIII
A collection of heterogenous conditions resulting from defective LIPID METABOLISM and characterized by ADIPOSE TISSUE atrophy. Often there is redistribution of body fat resulting in peripheral fat wasting and central adiposity. They include generalized, localized, congenital, and acquired lipodystrophy.
An enzyme that catalyzes the formation of glycerol 3-phosphate from ATP and glycerol. Dihydroxyacetone and L-glyceraldehyde can also act as acceptors; UTP and, in the case of the yeast enzyme, ITP and GTP can act as donors. It provides a way for glycerol derived from fats or glycerides to enter the glycolytic pathway. EC 18.104.22.168.
A phenomenon that is observed when a small subgroup of a larger POPULATION establishes itself as a separate and isolated entity. The subgroup's GENE POOL carries only a fraction of the genetic diversity of the parental population resulting in an increased frequency of certain diseases in the subgroup, especially those diseases known to be autosomal recessive.
Tissue-selective expression of alpha-dystrobrevin is determined by multiple promoters. (1/670)alpha-Dystrobrevin, the mammalian orthologue of the Torpedo 87-kDa postsynaptic protein, is a dystrophin-associated and dystrophin-related protein. Knockout of the gene in the mouse results in muscular dystrophy. The control of the alpha-dystrobrevin gene in the various tissues is therefore of interest. Multiple dystrobrevin isoforms differing in their domain content are generated by alternative splicing of a single gene. The data presented here demonstrate that expression of alpha-dystrobrevin from three promoters, that are active in a tissue-selective manner, also plays a role in the function of the protein in different tissues. The most proximal promoter A is active in brain and to a lesser extent in lung, whereas the most distal promoter B, which possesses several Sp1 binding sites, is restricted to brain. Promoter C, which contains multiple consensus myogenic binding sites, is up-regulated during in vitro myoblast differentiation. Interestingly, the organization and the activity of the alpha-dystrobrevin promoters is reminiscent of those in the dystrophin gene. Taken together we suggest that the multipromoter system, distributed over a region of 270 kilobases at the 5'-end of the alpha-dystrobrevin gene, has been developed to allow the regulation of this gene in different cell types and/or different developmental stages. (+info)
Hindlimb immobilization applied to 21-day-old mdx mice prevents the occurrence of muscle degeneration. (2/670)Dystrophin-deficient skeletal muscles of mdx mice undergo their first rounds of degeneration-regeneration at the age of 14-28 days. This feature is thought to result from an increase in motor activity at weaning. In this study, we hypothesize that if the muscle is prevented from contracting, it will avoid the degenerative changes that normally occur. For this purpose, we developed a procedure of mechanical hindlimb immobilization in 3-wk-old mice to restrain soleus (Sol) and extensor digitorum longus (EDL) muscles in the stretched or shortened position. After a 14-day period of immobilization, the striking feature was the low percentage of regenerated (centronucleated) myofibers in Sol and EDL muscles, regardless of the length at which they were fixed, compared with those on the contralateral side (stretched Sol: 8.4 +/- 6.5 vs. 46.6 +/- 10.3%, P = 0.0008; shortened Sol: 1.2 +/- 1.6 vs. 50.4 +/- 16.4%, P = 0.0008; stretched EDL: 05 +/- 0.5 vs. 32.9 +/- 17.5%, P = 0. 002; shortened EDL: 3.3 +/- 3.1 vs. 34.7 +/- 11.1%, P = 0.002). Total numbers of myofibers did not change with immobilization. This study shows that limb immobilization prevents the occurrence of the first round of myofiber necrosis in mdx mice and suggests that muscle contractions play a role in the skeletal muscle degeneration of dystrophin-deficient mdx mouse muscles. (+info)
Increased calcium entry into dystrophin-deficient muscle fibres of MDX and ADR-MDX mice is reduced by ion channel blockers. (3/670)1. Single fibres were enzymatically isolated from interosseus muscles of dystrophic MDX mice, myotonic-dystrophic double mutant ADR-MDX mice and C57BL/10 controls. The fibres were kept in cell culture for up to 2 weeks for the study of Ca2+ homeostasis and sarcolemmal Ca2+ permeability. 2. Resting levels of intracellular free Ca2+, determined with the fluorescent Ca2+ indicator fura-2, were slightly higher in MDX (63 +/- 20 nM; means +/- s.d.; n = 454 analysed fibres) and ADR-MDX (65 +/- 12 nM; n = 87) fibres than in controls (51 +/- 20 nM; n = 265). 3. The amplitudes of electrically induced Ca2+ transients did not differ between MDX fibres and controls. Decay time constants of Ca2+ transients ranged between 10 and 55 ms in both genotypes. In 50 % of MDX fibres (n = 68), but in only 20 % of controls (n = 54), the decay time constants were > 35 ms. 4. Bath application of Mn2+ resulted in a progressive quench of fura-2 fluorescence emitted from the fibres. The quench rate was about 2 times higher in MDX fibres (3.98 +/- 1.9 % min-1; n = 275) than in controls (2.03 +/- 1.4 % min-1; n = 204). The quench rate in ADR-MDX fibres (2.49 +/- 1.4 % min-1; n = 87) was closer to that of controls. 5. The Mn2+ influx into MDX fibres was reduced to 10 % by Gd3+, to 19 % by La3+ and to 47 % by Ni2+ (all at 50 microM). Bath application of 50 microM amiloride inhibited the Mn2+ influx to 37 %. 6. We conclude that in isolated, resting MDX muscle fibres the membrane permeability for divalent cations is increased. The presumed additional influx of Ca2+ occurs through ion channels, but is well compensated for by effective cellular Ca2+ transport systems. The milder dystrophic phenotype of ADR-MDX mice is correlated with a smaller increase of their sarcolemmal Ca2+ permeability. (+info)
Dynamics of myoblast transplantation reveal a discrete minority of precursors with stem cell-like properties as the myogenic source. (4/670)Myoblasts, the precursors of skeletal muscle fibers, can be induced to withdraw from the cell cycle and differentiate in vitro. Recent studies have also identified undifferentiated subpopulations that can self-renew and generate myogenic cells (Baroffio, A., M. Hamann, L. Bernheim, M.-L. Bochaton-Pillat, G. Gabbiani, and C.R. Bader. 1996. Differentiation. 60:47-57; Yoshida, N., S. Yoshida, K. Koishi, K. Masuda, and Y. Nabeshima. 1998. J. Cell Sci. 111:769-779). Cultured myoblasts can also differentiate and contribute to repair and new muscle formation in vivo, a capacity exploited in attempts to develop myoblast transplantation (MT) for genetic modification of adult muscle. Our studies of the dynamics of MT demonstrate that cultures of myoblasts contain distinct subpopulations defined by their behavior in vitro and divergent responses to grafting. By comparing a genomic and a semiconserved marker, we have followed the fate of myoblasts transplanted into muscles of dystrophic mice, finding that the majority of the grafted cells quickly die and only a minority are responsible for new muscle formation. This minority is behaviorally distinct, slowly dividing in tissue culture, but rapidly proliferative after grafting, suggesting a subpopulation with stem cell-like characteristics. (+info)
Extensive but coordinated reorganization of the membrane skeleton in myofibers of dystrophic (mdx) mice. (5/670)We used immunofluorescence techniques and confocal imaging to study the organization of the membrane skeleton of skeletal muscle fibers of mdx mice, which lack dystrophin. beta-Spectrin is normally found at the sarcolemma in costameres, a rectilinear array of longitudinal strands and elements overlying Z and M lines. However, in the skeletal muscle of mdx mice, beta-spectrin tends to be absent from the sarcolemma over M lines and the longitudinal strands may be disrupted or missing. Other proteins of the membrane and associated cytoskeleton, including syntrophin, beta-dystroglycan, vinculin, and Na,K-ATPase are also concentrated in costameres, in control myofibers, and mdx muscle. They also distribute into the same altered sarcolemmal arrays that contain beta-spectrin. Utrophin, which is expressed in mdx muscle, also codistributes with beta-spectrin at the mutant sarcolemma. By contrast, the distribution of structural and intracellular membrane proteins, including alpha-actinin, the Ca-ATPase and dihydropyridine receptors, is not affected, even at sites close to the sarcolemma. Our results suggest that in myofibers of the mdx mouse, the membrane- associated cytoskeleton, but not the nearby myoplasm, undergoes widespread coordinated changes in organization. These changes may contribute to the fragility of the sarcolemma of dystrophic muscle. (+info)
Membrane targeting and stabilization of sarcospan is mediated by the sarcoglycan subcomplex. (6/670)The dystrophin-glycoprotein complex (DGC) is a multisubunit complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. The proteins of the DGC are structurally organized into distinct subcomplexes, and genetic mutations in many individual components are manifested as muscular dystrophy. We recently identified a unique tetraspan-like dystrophin-associated protein, which we have named sarcospan (SPN) for its multiple sarcolemma spanning domains (Crosbie, R.H., J. Heighway, D.P. Venzke, J.C. Lee, and K.P. Campbell. 1997. J. Biol. Chem. 272:31221-31224). To probe molecular associations of SPN within the DGC, we investigated SPN expression in normal muscle as a baseline for comparison to SPN's expression in animal models of muscular dystrophy. We show that, in addition to its sarcolemma localization, SPN is enriched at the myotendinous junction (MTJ) and neuromuscular junction (NMJ), where it is a component of both the dystrophin- and utrophin-glycoprotein complexes. We demonstrate that SPN is preferentially associated with the sarcoglycan (SG) subcomplex, and this interaction is critical for stable localization of SPN to the sarcolemma, NMJ, and MTJ. Our experiments indicate that assembly of the SG subcomplex is a prerequisite for targeting SPN to the sarcolemma. In addition, the SG- SPN subcomplex functions to stabilize alpha-dystroglycan to the muscle plasma membrane. Taken together, our data provide important information about assembly and function of the SG-SPN subcomplex. (+info)
Delineation of genomic deletion in cardiomyopathic hamster. (7/670)Cardiomyopathic hamster is a representative animal model for autosomal recessive cardiomyopathy. We have previously shown that the transcript of delta-sarcoglycan is missing in the heart of cardiomyopathic hamster due to genomic deletion. Here we define the normal genomic region deleted in cardiomyopathic hamster, which spans about 30 kb interval and includes the two first exons of the delta-sarcoglycan gene. RNA blot analysis using genomic DNA fragments covering the entire deletion as probes failed to detect any transcript other than delta-sarcoglycan in normal hamster heart, suggesting that delta-sarcoglycan is the only transcript defective in the heart of cardiomyopathic hamster. (+info)
Laminin polymerization induces a receptor-cytoskeleton network. (8/670)The transition of laminin from a monomeric to a polymerized state is thought to be a crucial step in the development of basement membranes and in the case of skeletal muscle, mutations in laminin can result in severe muscular dystrophies with basement membrane defects. We have evaluated laminin polymer and receptor interactions to determine the requirements for laminin assembly on a cell surface and investigated what cellular responses might be mediated by this transition. We found that on muscle cell surfaces, laminins preferentially polymerize while bound to receptors that included dystroglycan and alpha7beta1 integrin. These receptor interactions are mediated through laminin COOH-terminal domains that are spatially and functionally distinct from NH2-terminal polymer binding sites. This receptor-facilitated self-assembly drives rearrangement of laminin into a cell-associated polygonal network, a process that also requires actin reorganization and tyrosine phosphorylation. As a result, dystroglycan and integrin redistribute into a reciprocal network as do cortical cytoskeleton components vinculin and dystrophin. Cytoskeletal and receptor reorganization is dependent on laminin polymerization and fails in response to receptor occupancy alone (nonpolymerizing laminin). Preferential polymerization of laminin on cell surfaces, and the resulting induction of cortical architecture, is a cooperative process requiring laminin- receptor ligation, receptor-facilitated self-assembly, actin reorganization, and signaling events. (+info)
Longitudinal study of bone mineral density in healthy, carrier, and affected dogs by Golden Retriever Muscular Dystrophy ...
The Golden Retriever Muscular Dystrophy (GRMD) is considered the most appropriate model of the Duchenne Muscular Dystrophy (DMD) in humans. Decrease in Bone Mineral Density (DMO) has been recognized in ambulatory and non-ambulatory boys with DMD. The Radiographic Optical Densitometry is a method to measure the bone mineral content. It was performed radiographing the proximal right tibia next to an aluminum stepwedge. Fifteen Golden Retriever dogs had been used, divided in three groups: Five healthy, five carriers and five affected by GRMD, monthly radiographed, from 3 to 9 months-old. These radiographies were analyzed by image processing software (ImageLab, Softium®). The proximal epiphysis had higher bone mineral density, followed for the metaphysic and diaphysis, respectively. All regions followed has influence the body weight. There was an increase of the bone mineral density in all regions of the three groups. The proximal metaphysis was thought to be the better region to evaluate the bone ...
JCI - Stable fetal cardiomyocyte grafts in the hearts of dystrophic mice and dogs.
This report documents the formation of stable fetal cardiomyocyte grafts in the myocardium of dystrophic dogs. Preliminary experiments established that the dystrophin gene product could be used to follow the fate of engrafted cardiomyocytes in dystrophic mdx mice. Importantly, ultrastructural analyses revealed the presence of intercalated discs consisting of fascia adherens, desmosomes, and gap junctions at the donor-host cardiomyocyte border. To determine if isolated cardiomyocytes could form stable intracardiac grafts in a larger species, preparations of dissociated fetal canine cardiomyocytes were delivered into the hearts of adult CXMD (canine X-linked muscular dystrophy) dogs. CXMD dogs, like Duchenne muscular dystrophy patients and mdx mice, fail to express dystrophin in both cardiac and skeletal muscle. Engrafted fetal cardiomyocytes, identified by virtue of dystrophin immunoreactivity, were observed to be tightly juxtaposed with host cardiomyocytes as long as 10 wk after engraftment, the ...
Muscular dystrophy-related quantitative and chemical changes in adenohypophysis GH-cells in golden retrievers. - Surrey...
Duchenne muscular dystrophy (DMD) is a recessive X-linked lethal condition which affects a boy in every 3300 births. It is caused by the absence of dystrophin, a protein occurring especially within the musculoskeletal system and in neurons in specific regions of the central nervous system (CNS). Growth hormone (GH) inhibition is believed to decrease the severity of DMD and could perhaps be used in its treatment. However, the underlying pathological mechanism is not known. The golden retriever muscular dystrophy dog (GRMD) represents an animal model in the study of DMD. In this paper we investigated the morphological aspects of the adenohypophysis as well as the total number and size of GH-granulated cells using design-based stereological methods in a limited number of dystrophic and healthy golden retrievers. GH-cells were larger (32.4%) in dystrophic dogs than in healthy animals (p=0.01) and they occupied a larger portion (62.5%) of the adenohypophysis volume (p=0.01) without changes in either ...
The effects of murine muscular dystrophy on the metabolic and homeosta by E Spargo, O E. Pratt et al.
Spargo, E; Pratt, O E.; and Daniel, P M., The effects of murine muscular dystrophy on the metabolic and homeostatic functions of the skeletal muscles. (1979). Subject Strain Bibliography 1979. 3092 ...
The dystrophic process in the central and peripheral nervous systems in relation to acute poisoning by phospho-organic...
Semantic Scholar extracted view of [The dystrophic process in the central and peripheral nervous systems in relation to acute poisoning by phospho-organic compounds]. by A. P. Shcherbakov
Respiratory function, electrocardiography and quality of life in individuals with muscular dystrophy.
All individuals in a Swedish county afflicted with any type of hereditary muscular dystrophy (MD) were identified and 57 (85 percent) of eligible individuals in the age range 16 to 64 were included in the study. Respiratory disturbances were estimated by means of spirometry and analysis of arterial blood gases, and 58 percent yielded abnormal results on at least one of these examinations. Elevated PCO2 was found more commonly than reduced forced vital capacity (FVC) and there was a moderate association between these parameters. Respiratory symptoms, most commonly breathlessness, were encountered in 79 percent. Pathologic ECG recordings were found in 21 individuals (37 percent). Conduction disturbances and affection of the myocard were most frequent in myotonic dystrophy. Quality of life was assessed by means of the Sickness Impact Profile instrument and the Kaasa test. The results showed that quality of life was significantly related to FVC and to the symptom of abnormal fatigue. Respiratory and ...
ICD-9 Code 359.0 -Congenital hereditary muscular dystrophy- Codify by AAPC
ICD-9 code 359.0 for Congenital hereditary muscular dystrophy is a medical classification as listed by WHO under the range - DISORDERS OF THE PERIPHER
Effect of Pentobarbitone Sodium on Serum Creatine Kinase of Normal and Dystrophic Hamsters | Clinical Science | Portland Press
1. The dose of pentobarbitone required for anaesthesia was significantly greater for dystrophic hamsters than for normal animals.. 2. Serum creatine kinase activity was significantly higher in dystrophic than in normal hamsters.. 3. Brain, heart and tibialis anterior muscle from dystrophic animals contained significantly less creatine kinase than the normal tissues.. 4. Creatine kinase in normal and dystrophic sera, as in skeletal muscles, consisted of MM isoenzyme. Heart creatine kinase consisted of both MM and MB types and brain contained only the BB isoenzyme.. 5. Pentobarbitone raised serum creatine kinase activity of normal and dystrophic hamsters to the same extent, elevation of enzyme activity being dependent on the amount of pentobarbitone injected.. 6. The sera of pentobarbitone-treated normal and dystrophic hamsters contained only the MM isoenzyme. ...
Effect of Pentobarbitone Sodium on Serum Creatine Kinase of Normal and Dystrophic Hamsters | Clinical Science
1. The dose of pentobarbitone required for anaesthesia was significantly greater for dystrophic hamsters than for normal animals.. 2. Serum creatine kinase activity was significantly higher in dystrophic than in normal hamsters.. 3. Brain, heart and tibialis anterior muscle from dystrophic animals contained significantly less creatine kinase than the normal tissues.. 4. Creatine kinase in normal and dystrophic sera, as in skeletal muscles, consisted of MM isoenzyme. Heart creatine kinase consisted of both MM and MB types and brain contained only the BB isoenzyme.. 5. Pentobarbitone raised serum creatine kinase activity of normal and dystrophic hamsters to the same extent, elevation of enzyme activity being dependent on the amount of pentobarbitone injected.. 6. The sera of pentobarbitone-treated normal and dystrophic hamsters contained only the MM isoenzyme.. ...
STUDIES IN DISORDERS OF MUSCLE. I. THE PROBLEM OF PROGRESSIVE MUSCULAR DYSTROPHY* | Annals of Internal Medicine | American...
Because of special circumstances present in Utah a study has been initiated which has as its object the investigation of diseases of muscle, especially progressive muscular dystrophy. Dr. Samuel C. Baldwin, an orthopedist recently deceased at the age of 90, initiated the local interest in this disorder. Dr. Baldwin himself studied a number of patients and with Dr. Fayette E. Stephens made valuable observations concerning the inheritance of this condition. The total incidence of dystrophy and other diseases of muscle in the area is unknown but there are many cases of muscular dystrophy in the local population. No data are ...
BIO TECHNOLOGY INFORMATION: Cell therapy strategies and improvements for muscular dystrophy
ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2; ALP, alkaline phosphatase; αsg, α-sarcoglycan; bg, natural killer (NK) cell-deficient mice (beige); BM, bone marrow; BMD, Becker muscular dystrophy; BMSCs, bone marrow-derived stem cells; BMT, bone marrow transplantation; βsg, β-sarcoglycan; c-MYC, cellular myelocytomatosis oncogene; cDNA, complementary DNA; Cxcr4, chemokine (C-X-C motif) receptor 4; DMD, Duchenne muscular dystrophy; ESCs, embryonic stem cells; FACS, fluorescence-activated cell sorting; Flk1, fetal liver kinase 1; GFP, green fluorescent protein; GLP-GMP, good laboratory practice-good manufacturing practice; GRMD, Golden Retriever muscular dystrophy; Gy, Gray (unit); HCT, haemopoietic cell transplantation; hMADS, human multi-potent adipose-derived stem cells; HLA, human leukocyte antigen; Hmgb1, high mobility group box 1; IGF1, Insulin-like growth factor 1; iPS, induced pluripotent stem cells; KLF4, Kruppel-like factor 4; KO, knockout; KSN, mice strain with high ...
Systemic administration of IGF-I enhances oxidative status and reduces contraction-induced injury in skeletal muscles of mdx...
Systemic administration of IGF-I enhances oxidative status and reduces contraction-induced injury in skeletal muscles of mdx dystrophic mice Academic Article ...
Evidence against a lymphocyte-mediated autoimmune etiology for murine by D W. Matheson
Matheson, D W., Evidence against a lymphocyte-mediated autoimmune etiology for murine muscular dystrophy. (1974). Subject Strain Bibliography 1974. 1360 ...
Alterations in Notch signalling in skeletal muscles from mdx and dko dystrophic mice and patients with Duchenne muscular...
New Findings What is the central question of this study? The Notch signalling pathway plays an important role in muscle regeneration, and activation of the pathway has been shown to enhance muscle regeneration in aged mice. It is unknown whether Notch activation will have a similarly beneficial effe …
DiVA - Search result
Objective: The aim of this study was to establish three-dimensional cultures originating from muscle biopsies and evaluate the viability and morphology. Method: Muscle biopsies from patients with suspected neuromuscular disorders were obtained and established as primary muscle tissue cultures. Tissue pieces, 1-2 mm of diameters, were placed in culture medium and subjected to sporadic stirring to prevent attachment and outgrowth as monolayer cells. Morphology and ability to attach to the surface were investigated by light microscopy. Viability was evaluated by Tc-99m-tetrofosmin uptake. After 1 month, histology was evaluated by light microscopy and immunocytochemistry. The findings of a healthy muscle and a dystrophic muscle were compared. Results: Initially, the tissue pieces were unshaped but formed spheroid-like structures during the culture period. For dystrophic muscle, attachment capacity to the surface was initially potent and decreased during the culture period, whereas control muscle ...
Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse | Read by QxMD
As a target for gene therapy, Duchenne muscular dystrophy (DMD) presents many obstacles but also an unparalleled prospect for correction by alternative splicing. The majority of mutations in the dystrophin gene occur in the region encoding the spectrin-like central rod domain, which is largely dispensable. Thus, splicing around mutations can generate a shortened but in-frame transcript, permitting translation of a partially functional dystrophin protein. We have tested this idea in vivo in the mdx dystrophic mouse (carrying a mutation in exon 23 of the dystrophin gene) by combining a potent transfection protocol with a 2-O-methylated phosphorothioated antisense oligoribonucleotide (2OMeAO) designed to promote skipping of the mutated exon*. The treated mice show persistent production of dystrophin at normal levels in large numbers of muscle fibers and show functional improvement of the treated muscle. Repeated administration enhances dystrophin expression without eliciting immune responses. Our ...
male golden retriever in heat
If you have a female Golden Retriever, then you need to know the signs that she is in heat. Golden Retriever in heat? Income School LLC also participates in affiliate programs with Bluehost, Clickbank, CJ, ShareASale, Chewy.com and other sites. Finally, the permanent option is to get your female spayed. My dog is about a year old and has a very good temperament. Some smaller dogs may go that often, but Golden Retrievers do not. Again, it depends on the dog and its breed. Again these are our suggestions and it is best that you consult a vet to determine the best age to neuter a Golden Retriever. Generally, your female Golden Retriever will be between 10 to 14 months old before she has her first heat. One thing that you can do to both protect your house and your dog is put her in a doggy diaper. Experts think that this is your dogs efforts to keep herself clean. There is so much to learn when it comes to your Golden Retriever. The changes are different for male and female puppies. I am Brian ...
Hope for muscular dystrophy patients: harnessing gene helps repair muscle damage - Healthcanal.com : Healthcanal.com
Led by Queen Mary University of London and published in the Journal of Experimental Medicine, the study provides the first proof of concept that manipulating the activity of this gene enhances the regeneration of the dystrophic muscle to a level where strength is visibly improved. For example, the mice were able to run on a treadmill for a longer time period and at a faster pace. This line of research will now be further developed and scientists aim to one day apply the treatment to patients with chronic muscle wasting such as muscular dystrophy.. Muscular dystrophy is a devastating and incurable condition. Duchenne Muscular Dystrophy - the deadliest form of the muscle-wasting disease - is caused by mutations in a gene which eventually cause muscle fibres to become damaged and waste away.. Duchenne Muscular Dystrophy is characterised by repeated cycles of muscle damage and repair, resulting in exhaustion of the muscle repair cells. It affects one in 3,500 boys and normally proves fatal by early ...
Dystrophin deficiency exacerbates skeletal muscle pathology in dysferlin-null mice | Skeletal Muscle | Full Text
Mutations in the genes coding for either dystrophin or dysferlin cause distinct forms of muscular dystrophy. Dystrophin links the cytoskeleton to the sarcolemma through direct interaction with β-dystroglycan. This link extends to the extracellular matrix by β-dystroglycans interaction with α-dystroglycan, which binds extracellular matrix proteins, including laminin α2, agrin and perlecan, that possess laminin globular domains. The absence of dystrophin disrupts this link, leading to compromised muscle sarcolemmal integrity. Dysferlin, on the other hand, plays an important role in the Ca2+-dependent membrane repair of damaged sarcolemma in skeletal muscle. Because dysferlin and dystrophin play different roles in maintaining muscle cell integrity, we hypothesized that disrupting sarcolemmal integrity with dystrophin deficiency would exacerbate the pathology in dysferlin-null mice and allow further characterization of the role of dysferlin in skeletal muscle. To test our hypothesis, we generated
Golden Retriever - Daxtons Friends
Golden Retrievers are very active and energetic dogs, especially when younger. They need to be stimulated mentally and physically. They require regular exercise and activity, or they may become bored and destructive. They LOVE to retrieve toys and will often walk around gently holding a toy in their mouth. The Golden Retriever does not require a large yard, but just enough space to play in.. This breed will require early socialization and training. Most Golden Retrievers are highly social and rarely have socialization issues. They just need to adjust to going to new places so they are not timid or afraid. Golden Retrievers need reward-based training for mental stimulation and to become well behaved dogs. They can be exuberant when young and can become hard to manage. They need to learn basic commands to help owners stay in control. They are eager to please their owners and are highly trainable. They can be easily distracted during training, but consistency will help the Golden Retriever stay on ...
Muscular dystrophy - Symptoms, Treatments and Resources for Muscular dystrophy
Muscular dystrophy - MedHelps Muscular dystrophy Center for Information, Symptoms, Resources, Treatments and Tools for Muscular dystrophy. Find Muscular dystrophy information, treatments for Muscular dystrophy and Muscular dystrophy symptoms.
X-linked muscular dystrophy with early contractures and cardiomyopathy (Emery-Dreifuss type)
The original Virginia family with X-linked muscular dystrophy with early contractures and cardiomyopathy (Emery-Dreifuss type) has been reinvestigated 25 years later. The findings confirm that a cardiomyopathy, presenting most often as atrioventricular block, is a significant feature of the disease, …
Muscular Dystrophy - Advances in Cellular and Molecular Basis, Diagnosis and Therapeutic Strategies | IntechOpen
|p| Muscular dystrophy represents a group of more than 30 inherited diseases that are characterized by muscle weakness and loss of muscle mass over time caused by genetic alterations. Even though more than 30 years have passed since the discovery of the first protein involved in a type of muscular dystrophy, there is no cure for these conditions yet.|br /| |br /| This book aims to provide an overview of the recent advances in the muscular dystrophy field addressing the cellular and molecular basis of muscular dystrophy, signaling pathways involved in skeletal muscle remodeling, miRNA profiling, serum, inflammatory and regenerative biomarkers. This book will discuss the currently available and innovative molecular techniques used for muscular dystrophy diagnosis (muscle biopsy, multiplex ligation-dependent probe amplification (MLPA), CGH-array, next-generation sequencing) as well as newest therapeutic approaches for different types of muscular dystrophies.|/p| |p| This book will be of great
Risas Golden Retrievers - Spay/Neuter Pros & Cons
Risas Golden Retrievers - Spay/Neuter Pros & Cons - Risas Goldens in Kansas KS is your source for Golden Retrievers, Golden Retriever Puppies, English Golden Retrievers and much more! Holistic dog food. NuVet Plus.
Golden Retriever - Wikipedia
The Golden Retriever is a large-sized breed of dog bred as gun dogs to retrieve shot waterfowl such as ducks and upland game birds during hunting and shooting parties, and were named retriever because of their ability to retrieve shot game undamaged. Golden Retrievers have an instinctive love of water, and are easy to train to basic or advanced obedience standards. They are a long-coated breed, with a dense inner coat that provides them with adequate warmth in the outdoors, and an outer coat that lies flat against their bodies and repels water. Golden Retrievers are well suited to residency in suburban or country environments. Although they need substantial outdoor exercise, they should be housed in a fenced area because of their instinctual tendency to roam. They shed copiously, particularly at the change of seasons, and require fairly regular grooming. The breed is a prominent participant in conformation shows for purebred dogs. The Golden Retriever is popular as a disability assistance dog ...
Effects of Early Spay or Neuter in Golden Retrievers - Golden Retriever Club of America
A search for a quality Golden Retriever to handle in junior showmanship led Liz Bultman to breeder Rhonda Hovan. As they got acquainted by e-mails, Hovan was impressed that Bultman wanted to be sure that Hovan would not require her to neuter or spay the dog at an early age.. The possible health effects of early spaying and neutering is a topic Hovan, the research facilitator for the Golden Retriever Club of America, holds close to her heart. For years when I looked at adult dogs that Id bred, I saw marked physical differences between those sold as show prospects and those sold as pets, says Hovan, of Akron, Ohio, who has bred Golden Retrievers under the Faera prefix for more than 40 years. The dogs sold as pets were tall and lanky, with no bone and pointy muzzles. Id look at them and wonder how they got so tall.. To read the whole article download using the button above!. ...
Muscular Dystrophy: theFacts
The muscular dystrophies are a group of genetic diseases that severely affect children and adults. For sufferers and their family, the illness presents enormous physical and psychological challenges. Written specifically for people with muscular dystrophy and their families, this new edition of Muscular dystrophy: the facts answers many of the questions asked about how and why it occurs, and how it will affect the life of a recently diagnosed child. Throughout, the different types of muscular dystrophy are described with a minimum of technical jargon. Questions relating to exercise, physiotherapy, surgery, and the emotional effects of the diseases are answered, and advice given on the problems of schooling and choice of career. Since publication of the 1st edition, the genes for almost all the different types of dystrophy have been identified, enabling prevention through genetic counselling, and relieving some of the worry for affected families. Drawn from his many years of experience treating ...
Center for Duchenne Muscular Dystrophy at UCLA | Muscle Cell Biology, Pathophysiology, and Therapeutics Training Program
Predoctoral and Postdoctoral Positions Available Application Deadline:. Friday, May 6, 2016 (5pm PST) The training program is open to any UCLA predoctoral (Ph.D. graduate student) or postdoctoral fellow who is a US citizen or permanent resident and whose research interest focuses on muscle cell biology and disease with an emphasis on muscular dystrophy. Muscle cell biology is an area of exciting growth in translational medicine. The muscular dystrophies are a clinically and genetically heterogeneous group of conditions characterized by progressive muscle degeneration. Translational research in the muscular dystrophies is expanding, as academic and industry partnerships yield new potential treatments that are currently being assessed in clinics around the world. The goal of the Muscle Cell Biology, Pathophysiology, and Therapeutics program is to capitalize on the momentum that arose from this explosion of translational research. The training program will capitalize on and bridge the talents of ...
Exon Skipping and Dystrophin Induction in Cardiac Muscle - Muscular Dystrophy
The requirement of muscle damage for effective delivery and AON induced dystro-phin expression is further supported by the result obtained in the cardiac muscle in the mdx mice after systemic treatment of both 2OMePS AON and PMO. Cardiac muscles in mdx mice are less affected by the dystrophic process and no significant pathology and functional impairment can be obviously demonstrated until late age. Consistently, only minimum amount of dystrophin expression can be detected in the cardiac muscle even after repeated injections of both 2OMePS AON and PMO in all mdx mice aged 6 months or younger (Lu et al. 2005; Alter et al. 2006), whereas the same treatment can induce high levels of dystrophin in skeletal muscles. There is a possibility that the special tissue structure (vasculature and membrane) and pattern of metabolism or gene expression regulation could be responsible for lower efficiency of AON delivery or exon skipping inside myonuclei. However, direct injection of AON into cardiac muscles ...
Barton Health | Health Library | Staywell Health Library | Muscular Dystrophy
Muscular Dystrophy What is muscular dystrophy? Muscular dystrophy (MD) is a broad term that describes a genetic (inherited) disorder of the muscles. Muscular dystrophy causes the muscles in the body to become very weak. The muscles break down and are replaced with fatty deposits over time. Other health problems commonly associated with muscular dystrophy include the following: Heart problems Scoliosis. A lateral, or sideways, curvature and rotation of the back bones (vertebrae), giving the appearance th...
Tadalafil and Sildenafil for Duchenne Muscular Dystrophy - Tabular View - ClinicalTrials.gov
Duchenne muscular dystrophy (DMD) is a rare, progressive and fatal muscle disease affecting boys and accounts for 80% of muscular dystrophy cases. Tadalafil and sildenafil are medications approved by the FDA for the treatment of erectile dysfunction and pulmonary hypertension. This class of medication improves muscle blood flow in a mouse model of muscular dystrophy, but their benefit to boys with DMD is unknown. The purpose of this study is to 1) determine if tadalafil or sildenafil can improve muscle blood flow during exercise in boys with DMD; and 2) to inform the design of a subsequent, randomized, multi-center trial with clinical endpoints.. The investigators will enroll boys with DMD between the ages of 7 and 15 years who are ambulatory and without clinical heart failure. Participants will undergo 6 visits over the course of 5 weeks. The initial visit will include a medical history, physical exam, echocardiogram, and blood draw to determine eligibility for the study. Boys will be given a ...
Tadalafil and Sildenafil for Duchenne Muscular Dystrophy - Full Text View - ClinicalTrials.gov
Duchenne muscular dystrophy (DMD) is a rare, progressive and fatal muscle disease affecting boys and accounts for 80% of muscular dystrophy cases. Tadalafil and sildenafil are medications approved by the FDA for the treatment of erectile dysfunction and pulmonary hypertension. This class of medication improves muscle blood flow in a mouse model of muscular dystrophy, but their benefit to boys with DMD is unknown. The purpose of this study is to 1) determine if tadalafil or sildenafil can improve muscle blood flow during exercise in boys with DMD; and 2) to inform the design of a subsequent, randomized, multi-center trial with clinical endpoints.. The investigators will enroll boys with DMD between the ages of 7 and 15 years who are ambulatory and without clinical heart failure. Participants will undergo 6 visits over the course of 5 weeks. The initial visit will include a medical history, physical exam, echocardiogram, and blood draw to determine eligibility for the study. Boys will be given a ...
The Golden Retriever: An Intelligent Worker and a Patient Family Dog - Wag Pet Boutique
The Golden Retriever is a breed that was developed out of necessity. In both Scotland and England bird hunting was a popular sport among the wealthy and something the lower classes depended on for food. It was this wild-fowling that led to a need for a dog skilled in retrieval. The original Goldens are believed to have descended from a yellow retriever purchased by the Scottish Lord Tweedmouth. This dog (named Nous) was used as a hunting dog and eventually bred to a Tweed Water Spaniel in an effort to create a smaller hunting dog. It is said that the puppies that resulted from this first breeding are the puppies that gave rise to every Golden Retriever we have today! This happened through a process of selective breeding with more Tweed Spaniels, Wavy-coated Retrievers, and Red Setters. By 1913, the Golden Retriever was officially recognized as its own breed in Great Britain and by 1925, they were registered as a breed with the AKC. It wouldnt be until the 1930s and 1940s, however, that the ...
Kyle Leon Reviews-Types of muscular dystrophy disease | Health Care Programs
Affects disease muscular dystrophy on different muscle groups and causes weakness of the muscles to varying degrees. muscular dystrophy type Duchenne (Duchenne Muscular Dystrophy): is the most common types of muscular dystrophy and the severity of the most part. Affects about one child out of 3,500 males (For girls They are carrying the gene responsible…
Contractile properties and susceptibility to exercise-induced damage of normal and mdx mouse tibialis anterior muscle |...
1. The functional properties of tibialis anterior muscles of normal adult (C57BL/10) and age-matched dystrophin-deficient (C57BL/10 mdx) mice have been investigated in situ. Comparisons were made between tibialis anterior muscle strength, rates of force development and relaxation, force-frequency responses and fatiguability. Subjecting mdx and C57 muscles to a regimen of eccentric exercise allowed the hypothesis to be tested that dystrophin-deficient muscles are more susceptible to exercise-induced muscle damage.. 2. mdx muscles were, on average, 30% stronger than C57 muscles and almost 80% heavier, but both had similar muscle lengths. Thus, although mdx muscles were stronger in absolute terms, their estimated force per unit cross-sectional area was significantly less than that of C57 muscles.. 3. The force-frequency relationships of C57 and mdx muscles differed in that whilst, at 40 Hz, the former developed 70% of the force developed at 100 Hz, the latter developed only 55% of the maximal ...
Lama2 Muscular Dystrophy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
MalaCards based summary : Lama2 Muscular Dystrophy, also known as laminin α2 chain-deficiency, is related to muscular dystrophy and congenital muscular dystrophy type 1a. An important gene associated with Lama2 Muscular Dystrophy is LAMA2 (Laminin Subunit Alpha 2). Affiliated tissues include skeletal muscle ...
New Study Aims to Improve Golden Retriever Health | About Golden Retrievers | PetMD
Owners are responsible for all costs associated with the annual exam, sample collection, and laboratory test results. Morris Animal Foundation will reimburse you for up to $75 of these costs per year after verification that the exam and sample collection has been completed. You may donate this compensation directly back to Morris Animal Foundation to support the Golden Retriever Lifetime Study.. If you can participate, please do so. According to the CLHP, cancer is the #1 cause of death in dogs over the age of two, and more than half of all golden retrievers die of the disease. The hope is that this study will identify the genetic, nutritional, and environmental risk factors for cancer and other diseases affecting goldens, and provide valuable information into prevention strategies, early diagnosis, and new treatments for cancer and other dog diseases. Check out the CLHP website for more information and to sign up either as an owner or veterinarian. Hopefully, this study (the largest and longest ...
7 Ways to Find a Quality Golden Retriever Puppy | All Golden Retriever
Your standards for quality in a golden retriever puppy will depend on whether you are adopting from a rescue or purchasing from a breeder. Either way, the seven ways to find a quality golden retriever puppy are
Dog-Care Facts Every Golden Retriever Owner Needs to Know
If you own, or are thinking about owning, a golden retriever, you need to know these golden retriever facts. Plus, get essential tips for golden retriever training and grooming. Were also sharing our favorite dog-friendly gift ideas.
FDA approves $89000 drug to treat Duchennes Muscular dystrophy
In an attempt to head off the sort of controversy that has followed other companies unforced price raises, the company has also promised that Emflaza will be made free for poorer patients through its assistance program, and its confident that insurance companies will cover the bulk of the drugs costs. We hope that this treatment option will benefit many patients with DMD.. For the last two decades, patients have been buying deflazacort from other countries ever since clinical trials demonstrated its effectiveness for treating Duchenne muscular dystrophy.. DMD is the most common type of muscular dystrophy. The first symptoms are usually seen between 3 and 5 years of age and worsen over time.. People who have DMD eventually lose the ability to carry out activities on their own and are wheelchair bound by the time they reach their early teen years. As the disease progresses, life-threatening heart and respiratory conditions can occur. It is more common among boys than among girls. Marathon had ...
DMOZ - Health: Conditions and Diseases: Neurological Disorders: Muscle Diseases: Muscular Dystrophies
The musculary dystrophies are a group of diseases characterized by progressive degeneration and/or loss of muscle fibers that result in loss of muscle strength. All or nearly all of them have a hereditary origin but details of the type of genetic defect and of the prognosis for the disease vary from type to type. Duchenne muscular dystrophy is the most common form, though there are at least 6 other forms of the disease. Several million people throughout the world have a form of muscular dystrophy. In the United States, it is estimated that 250,000 suffer from a form of muscular dystrophy.
Symptoms of Muscular dystrophy, congenital, type 1C - RightDiagnosis.com
Symptoms of Muscular dystrophy, congenital, type 1C including 12 medical symptoms and signs of Muscular dystrophy, congenital, type 1C, alternative diagnoses, misdiagnosis, and correct diagnosis for Muscular dystrophy, congenital, type 1C signs or Muscular dystrophy, congenital, type 1C symptoms.
Muscular Dystrophy | RxWiki
Muscular Dystrophy, Read about Muscular Dystrophy symptoms, causes, diagnosis, and treatment. Also read Muscular Dystrophy articles about how to live with Muscular Dystrophy, and more.
Enzootic muscular dystrophy synonyms, enzootic muscular dystrophy antonyms - FreeThesaurus.com
Synonyms for enzootic muscular dystrophy in Free Thesaurus. Antonyms for enzootic muscular dystrophy. 2 words related to enzootic: endemic, endemical. What are synonyms for enzootic muscular dystrophy?
Baldwin City Gazette : Neurofibromatosis Network to host #NFStrong 5K Walk in Kansas City
Neurofibromatosis (NF) is a genetic disorder that involves the uncontrolled growth of tumors along the nervous system, which can result in terrible disfigurement, deformity, deafness, blindness, brain tumors, cancer and death. NF is the most common neurological disorder caused by a single gene and is more common than Cystic Fibrosis, hereditary Muscular Dystrophy, Huntingtons disease and Tay Sachs combined. Because of NFs close connection to many common diseases and disorders, such as cancer, learning disabilities, heart disease, memory loss, and brain tumors, research on NF stands to benefit 175 million Americans in this generation alone ...
New knowledge about muscular dystrophy ( The most common form of muscular dys...)
Health, ...The most common form of muscular dystrophy among adults is dystrophia ...When this RNA which contains thousands of CUG nucleotide repeats bui...Enzyme characterisation in muscular dystrophy patients ...The researchers work at the Department of Molecular Biology and Geneti...,New,knowledge,about,muscular,dystrophy,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
JCI - Stem cell therapy for muscular dystrophies
Muscular dystrophies comprise a heterogeneous group of genetic disorders characterized by progressive muscle wasting and weakness (1, 2). In muscular dystrophies, muscle dysfunction arises from the mutations of genes encoding different cellular components, including proteins associated with the sarcolemma, extracellular matrix, nuclear membrane, and sarcomeric apparatus (3, 4). Different forms of dystrophy differ in terms of age of onset, severity of symptomatic progression, and distribution of affected muscles (1, 3). Depending on the molecular etiology, muscular dystrophies can present clinically relevant defects beyond the skeletal muscle compartment (3). In particular, cardiac involvement is present in several forms of dystrophy (3, 5).. With an incidence of approximately 1 in 5000 male newborns, Duchenne muscular dystrophy (DMD; OMIM 310200) is the most frequent and one of the most severe forms of muscular dystrophy (1, 3). DMD patients typically present with progressive weakness of limb ...
Nitric oxide controls fat deposition in dystrophic skeletal muscle by regulating fibro-adipogenic precursor differentiation -...
Fingerprint Dive into the research topics of Nitric oxide controls fat deposition in dystrophic skeletal muscle by regulating fibro-adipogenic precursor differentiation. Together they form a unique fingerprint. ...
GR - PRA1 for Golden retriever - Slovgen.sk
Description: Progressive retinal atrophy (PRA) is a category of genetic mutations, which can cause blindness. It is the canine equivalent of Retinitis pigmentosa (RP) in humans and is characterized by loss of vision due to degeneration of the photoreceptor cells of the retina. Various forms of PRA have been identified in more than 100 dog breeds which were caused by numerous mutation types. In Golden retriever breed there are 3 common variants of PRA. First of them is PRA-prcd, but only a small number of PRA-affected Golden retrievers have been found to be homozygous for this mutation. Other variants are GR-PRA1 and GR-PRA2. GR-PRA1 has an autosomal recessive type of inheritance. It is a result of a mutation (c.2601_2602insC) in gene SLC4A3, it causes a shift in the reading frame, formation of non-functional protein. In 56% of cases, this variant is a cause of the PRA disease in this breed.. Inheritance: autosomal recessive. Mutation: c.2601_2602insC in gene SLC4A3. Sample: EDTA whole blood (1.0 ...
Golden retrievers key to lifetime dog cancer study - *GJ LIFESTYLES - fosters.com - Dover, NH
LOS ANGELES - When Jay Mesinger heard about a study seeking golden retrievers to help fight canine cancer, he immediately signed up 2-year-old Louie.He and his wife know firsthand the toll of canine cancer: Louie is their fourth golden retriever. The first three died of cancer.They all had long lives but were taken by complications from one kind of cancer or another, said the Boulder, Colo., businessman.For Louie and 2,999 other purebred goldens, it will be the study of a lifetime.
Golden Retriever - All the Features, Prices and Where to find one
Master your knowledge of the Golden Retriever: discover breed standards, fun facts, breed features assessed and organised by adaptability, health, learning skills, exercise requirements and maintenance cost. Are you ready to adopt an Golden Retriever? Our advice can help you make a choice.
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References - Muscular Dystrophy - Fitness VIP
Abmayr, S., Gregorevic, P., Allen, J.M., and Chamberlain, J.S. (2005). Phenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by Igf1 codelivery. Mol Ther 12, 441-450.. Ahn, A.H., and Kunkel, L.M. (1993). The structural and functional diversity of dystrophin. Nat Genet 3, 283-291.. Allocca, M., Doria, M., Petrillo, M., Colella, P., Garcia-Hoyos, M., Gibbs, D., Kim, S.R., Maguire, A., Rex, T.S., Di Vicino, U., et al. (2008). Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice. J Clin Invest 118, 1955-1964.. Alter, J., Lou, F., Rabinowitz, A., Yin, H., Rosenfeld, J., Wilton, S.D., Partridge, T.A., and Lu, Q.L. (2006). Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology. Nat Med 12, 175-177.. American Academy of Pediatrics. (2005). Cardiovascular health supervision for individuals affected by Duchenne or Becker muscular ...
Cerebral Pasy Vs Muscular Dystrophy Essay Research
Cerebral Pasy Vs. Muscular Dystrophy Essay, Research Paper Muscular dystrophy is a rare inherited muscle disease in which the muscle fibers are unusually susceptible to damage. The muscles, primarily the voluntary muscles, become progressively weaker. In the late stages of muscular dystrophy, muscle fibers often are replaced by fat and connective tissue.
Muscular Dystrophy - Pipeline Review, H2 2016
Summary Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline guide Muscular Dystrophy - Pipeline Review, H2 2016, provides an overview of the Muscular Dystrophy (Musculoskeletal Disorders) pipeline landscape. Muscular dystrophy is a group of diseases in which muscle fibers are unusually susceptible to damage. These damaged muscles become progressively weaker. Symptoms
What is Muscular Dystrophy, Symptoms & Treatment of Muscular Dystrophy @ Meditourz
Muscular Dystrophy is a group of more than 30 inherited disorders that cause the muscles to gradually weaken and break down. Our revolutionizing stem cell therapy helps stabilize muscular dystrophy symptoms and slow down progression of the disease
Lipid mapping in human dystrophic muscle by cluster-time-of-flight secondary ion mass spectrometry imaging. - pdf descargar
Lipid mapping in human dystrophic muscle by cluster-time-of-flight secondary ion mass spectrometry imaging.. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Unionville Run For Our Sons 5K and Family Fun Day - Parent Project Muscular Dystrophy
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Conditional EU Approval of Muscular Dystrophy Drug Applauded
For the Muscular Dystrophy Association, the go-ahead for a targeted drug offers tangible hope to patients with Duchenne muscular dystrophy.
Friends of FSH Research :: FSHD: The Most Prevalent Form of Muscular Dystrophy
The current update of the report on Prevalence or reported number of published cases listed in alphabetical order of disease lists FSHD as occurring in approximately 7 out of 100,000 individuals. This is compared to 5 out of 100,000 individuals for Duchenne and Becker muscular dystrophy, formerly considered the most prevalent form of muscular dystrophy.
Coagulology, biochemical profile and muscle pathology in calves diagnosed with nutritional muscular dystrophy - Polish Journal...
PAN Czytelnia Czasopism, Coagulology, biochemical profile and muscle pathology in calves diagnosed with nutritional muscular dystrophy - Polish Journal of Veterinary Sciences
"Animal Models - Parent Project Muscular Dystrophy". parentprojectmd.org. Retrieved 2016-05-03. v t e. ... The mdx mouse is a popular model for studying Duchenne muscular dystrophy (DMD). The mdx mouse has a point mutation in its DMD ... Bulfield, G.; Siller, W. G.; Wight, P. A.; Moore, K. J. (1984). "X chromosome-linked muscular dystrophy (mdx) in the mouse". ...
Dental pulp stem cells
2008 DPSC 1st animal studies begin for heart therapies. 2008 IDPSC 1st animal study began for muscular dystrophy therapies. ... 2007 DPSC 1st animal studies begin for bone regeneration. 2007 DPSC 1st animal studies begin for dental end uses. ... 2008 DPSC 1st animal studies begin for regenerating brain tissue. 2008 DPSC 1st advanced animal study for bone grafting ... "Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) ...
"Cytoplasmic gamma-actin expression in diverse animal models of muscular dystrophy". Neuromuscular Disorders. 17 (7): 569-74. ... "Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy". The ... In a skeletal muscle-specific knockout of gamma-actin in mice, these animals showed no detectable abnormalities in development ...
... is also an excellent animal model to study congenital muscular dystrophies including CMD Type 1 A (CMD 1A) caused by ... Muscular dystrophies (MD) are a heterogeneous group of genetic disorders that cause muscle weakness, abnormal contractions and ... Zebrafish is widely used as model organism to study muscular dystrophies. For example, the sapje (sap) mutant is the zebrafish ... Plantié E, Migocka-Patrzałek M, Daczewska M, Jagla K (April 2015). "Model organisms in the fight against muscular dystrophy: ...
Limb-girdle muscular dystrophy
The review goes on to state that animal models for LGMD2 have been used to analyse therapeutic medications. Also adding that ... "limb-girdle muscular dystrophy". Genetics Home Reference. Retrieved 2016-04-22.. *^ a b c d "Limb-Girdle Muscular Dystrophy: ... "Limb-girdle muscular dystrophy".. *^ "Limb-Girdle Muscular Dystrophy Treatment & Management: Medical Care, Surgical Care, ... Limb-girdle muscular dystrophy or (LGMD) is a genetically and clinically heterogeneous group of rare muscular dystrophies. ...
2008). "Muscular dystrophy associated alpha-dystroglycan deficiency in Sphynx and Devon Rex cat". Neuromuscular Disorders. 12. ... Thanks to various breeding efforts, their lineages resulted in the affectionate animal we love today. "Sphynx Standard 05/02/ ... Congenital myasthenic syndrome (CMS) (previously referred to as muscular dystrophy, myopathy or spasticity) is a type of ... "Sphynx - Hereditary Myopathy". The International Animal Welfare Science Society. Retrieved 30 October 2019. Martin, P. T.; et ...
Bansal D, Campbell KP (April 2004). "Dysferlin and the plasma membrane repair in muscular dystrophy". Trends in Cell Biology. ... In other animals, ferlin mutations can cause infertility. Ferlins are type II transmembrane proteins (N-terminus on the ... Interestingly, dysferlin C2B does not bind calcium, however, mutations in this domain can still cause muscular dystrophy. Some ... Mutations in ferlins can cause human diseases such as muscular dystrophy and deafness. Abnormalities in expression of myoferlin ...
"The International Animal Welfare Science Society. Retrieved 2019-10-30.. *^ Martin, P. T.; et al. (2008). "Muscular dystrophy ... Congenital Myasthenic Syndrome (CMS) (previously referred to as Muscular Dystrophy, Myopathy or Spasticity) is a type inherited ... "animal.discovery.com. Animal Planet (Discovery Communications). 2008-09-10. Retrieved 2010-10-26.. ... Thanks to various breeding efforts, their lineages resulted in the affectionate animal we love today.. ...
... was used to ameliorate the effects of muscular dystrophy in golden retrievers with a congenital muscular dystrophy. The dogs ... given allogeneic cells survived; control animals died within 1 year. Pericyte Mesoderm Endothelium List of human cell types ... Recent work has suggested their application for stem cell therapies for muscular dystrophy. Experiments in alpha-sarcoglycan ...
Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular Dystrophy". The ... "In Lab, SLU Research Halts Toxic Protein Linked to Muscular Dystrophy". www.newswise.com. Newswise. 23 October 2019. Retrieved ... 12 July 2019). "P38α Regulates Expression of DUX4 in Facioscapulohumeral Muscular Dystrophy". bioRxiv: 700195. doi:10.1101/ ... is an investigational drug being developed by Fulcrum Therapeutics for the treatment of facioscapulohumeral muscular dystrophy ...
"Electrotransfer of naked DNA in the skeletal muscles of animal models of muscular dystrophies". Gene Therapy. 8 (14): 1097-107 ...
... is a drug which may serve as a vehicle for gene therapy, in the treatment of Duchenne and Becker muscular dystrophy ... is currently being investigated with the use of both canine and primate animal models. Biostrophin is being manufactured by ... with funding provided by the Muscular Dystrophy Association. Ataluren Rimeporide (experimental) Khurdayan VK, Bozzo J, Prous JR ...
"A Nonsense Variant in COL6A1 in Landseer Dogs with Muscular Dystrophy". NCBI. PMC 4683634. v t e. ... In the 20th century the solid black coloration became more popular and supplanted the bi-colored animals, so much so that in ... A study in 2015 found a special gene in Landseers with muscle dystrophy called COL6A1 that could provide researchers with ... Animal Genetics. 38 (6): 539-549. doi:10.1111/j.1365-2052.2007.01664.x. PMID 18052939. S2CID 28968274. Steffen, F.; Bilzer, T ...
As of May 2015[update], the substance has demosntrated positive efficay in several animal models of Duchenne Muscular Dystrophy ... It has also been recently tested in young boys with Duchenne Muscular Dystrophy aged 6 to 11 years. Ataluren Biostrophin ( ... Rimeporide is an experimental drug for the treatment of Duchenne muscular dystrophy, being developed by the EspeRare foundation ... "EspeRare's Rimeporide receives Orphan Drug Designation in Duchenne Muscular Dystrophy". EspeRare. 4 May 2015. "Our mission and ...
Muscular Dystrophy Campaign. "New collaboration to support omigapil clinical trial for congenital muscular dystrophy". ... as well as in rodent and non-rodent animal models of neurodegeneration. Omigapil rescues in vitro PC12 cells from rotenone ... The mouse model of laminin-α2-deficient congenital muscular dystrophy (MDC1A) was found to positively respond to omigapil with ... Miyagoe-Suzuki Y, Nakagawa M, Takeda S (2000). "Merosin and congenital muscular dystrophy". Microsc. Res. Tech. 48 (3-4): 181- ...
Duchenne muscular dystrophy, and other cardiovascular diseases. Gadolinium (Gd3+) and other lanthanides have been shown to ... They have been found to be used for volume sensing in animals and blood pressure regulation. Bacteria have been shown to ... Atrial fibrillation Abnormalities in the function of MS channels can cause: Neuronal disease Muscular degeneration. Cardiac ... other types of MSCs are probably the basis of the senses of hearing and touch and sense the stress needed for muscular ...
Scientists focused on diseases caused by single-gene defects, such as cystic fibrosis, haemophilia, muscular dystrophy, ... Horn PA, Morris JC, Neff T, Kiem HP (September 2004). "Stem cell gene transfer - efficacy and safety in large animal studies". ... In May, onasemnogene abeparvovec (Zolgensma) was approved by the European Union for the treatment of spinal muscular atrophy in ... The technique is named immunoprophylaxis by gene transfer (IGT). Animal tests for antibodies to ebola, malaria, influenza, and ...
Further research into myostatin and the myostatin gene may lead to therapies for muscular dystrophy. The idea is to introduce ... In both cases the resulting animals were significantly more muscular. However, rabbits without myostatin also exhibited an ... It remains unclear as to whether long-term treatment of muscular dystrophy with myostatin inhibitors is beneficial, as the ... Muscular dystrophy Muscle hypertrophy Myostatin-related muscle hypertrophy Superhuman strength GRCh38: Ensembl release 89: ...
Roanoke Rail Yard Dawgs
... annual hockey game to benefit the Muscular Dystrophy Association. The game is played at the Berglund Center and pits the ... a local organization that operates the largest private animal shelter in the Roanoke Valley, as well as a low cost Community ... Pet Clinic and farm animal sanctuary. Virginia Museum of Transportation- a large museum in Downtown Roanoke that hosts a number ...
Head, Stewart I. (29 October 2017). "Antioxidant therapy in a mouse model of Duchenne muscular dystrophy: some promising ... In animal models, it reduced age-related hearing loss. It has been shown effective in the treatment of Unverricht-Lundborg ... In mouse mdx models of Duchenne's muscular dystrophy, treatment with 1-2% acetylcysteine in drinking water significantly ... Animal studies have also demonstrated its efficacy in reducing the damage associated with moderate traumatic brain or spinal ...
... a muscular dystrophy. During the operation that was meant to save her life, there was an accident with the Coil that was ... She is good at using drones in the form of animals like pigeons and bats. Miyabi Azumaya (四阿屋 雅, Azumaya Miyabi) Voiced by: ...
Studies on erythrocytes in Duchenne muscular dystrophy. 7th Symposium on Current Research in Muscular Dystrophy, Birmingham. ... 2: 37-42 (1985). Relative vapour pressure lowering in the skeletal muscles of different animals and in the denervated and ... Myoglobinuria in Duchenne Muscular Dystrophy. J. Pak. Med. Assoc. 23: 95-99 (1984). Binding of Cardiac Glycoside Ouabain to ... 1(2): 102-104 (1979). An evaluation of some carrier detection techniques in Duchenne muscular dystrophy. J. Neurol. Sci. 43: ...
Genetically modified animal
... heart disease and muscular dystrophy. These treatments only affect somatic cells, meaning any changes would not be inheritable ... Genetically modified animals are animals that have been genetically modified for a variety of purposes including producing ... Duchenne muscular dystrophy". Gene Therapy. 13 (24): 1677-85. doi:10.1038/sj.gt.3302877. PMID 17066097. "1990 The Declaration ... The first transgenic animals were produced by injecting viral DNA into embryos and then implanting the embryos in females. It ...
... including muscular dystrophy, cancer and kidney disease". Double-muscled breeding is done to get more meat and less fat. ... Bailey, Mears, & Mir). Animals that are double-muscled have a higher carcass yield but this does come with new problems for the ... Animals homozygous for myostatin mutation (inheriting a mutant copy of myostatin from both sire and dam) also have improved ... "Breeds of Livestock - Belgian Blue Cattle - Breeds of Livestock, Department of Animal Science". afs.okstate.edu. Glass, David J ...
His field man got muscular dystrophy, and in 1991 Witte filed for bankruptcy. The conflict drew the attention of several ... The corn hardly grew; what was grown was sold as animal feed. DeYoung, worried about the liability of the toxic waste, tried to ...
Muscular Dystrophy Association. July 2010. Archived from the original on June 29, 2015. Retrieved February 24, 2015. "Twilight ... He appeared in a PETA campaign, encouraging people to adopt animals rather than to buy them from pet stores. He is also ... In 2010, he was named a Celebrity Ambassador by the Muscular Dystrophy Association. In his role, Stewart is helping raise ...
Flightless fruit fly
... spinobulbar muscular atrophy, myotonic dystrophy, dystrophinopathies and other inherited neuromuscular diseases. Other ... applications of flightless flies include using them as convenient feeders for a variety of companion animals and even as test ... A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle. J. Cell Biol. 176: ... Flightless fly models have been especially useful for the study of human neuromuscular diseases such as spinal muscular atrophy ...
Muscular dystrophy. Caveolin-3 has been implicated in the development of certain types of muscular dystrophy (Limb-girdle ... However, knock-out animals do develop abnormal, hypertrophic lungs, and cardiac myopathy, leading to a reduction in lifespan. ... Galbiati F, Razani B, Lisanti MP (October 2001). "Caveolae and caveolin-3 in muscular dystrophy". Trends Mol Med. 7 (10): 435- ... muscular dystrophy). References. *^ Tang Z, Scherer PE, Okamoto T, Song K, Chu C, Kohtz DS, Nishimoto I, Lodish HF, ...
Genetically modified organism
Foster K, Foster H, Dickson JG (December 2006). "Gene therapy progress and prospects: Duchenne muscular dystrophy". Gene Ther. ... EFSA (2012). Genetically modified animals Europe: EFSA. *^ Murray, Joo (20). Genetically modified animals. Canada: Brainwaving ... and muscular dystrophy.. Conservation use. Genetically modified organisms have been used to conserve European wild rabbits ... genetic modification can also be used to allow the animal to grow human organs inside their body. Such animals, which are hence ...
Raeburn, Paul (July 31, 1984). "Muscular Dystrophy Identified In Mouse, Speeding Search For A Cure". Domestic News. The ... in 1964 he enlisted the Institute of Animal Genetics in Edinburgh, studying for a Diploma in Animal Genetics. Having gained ... responsible to cause the Duchenne and the Becker muscular dystrophy in humans, and thus opening a path to a possible cure. He ... Production of animal feedstuff, cereals, milk, meat, benefited all from the findings of his research. Not only that, but this ...
Marianapolis Preparatory School
Their dash into the water on Thanksgiving morning helps to raise money for the Muscular Dystrophy Association. Spirit Week: ... and even visiting animal shelters. Marianapolis students help to make a big difference in the local community. S.P.A.M.: S.P.A. ... Thanksgiving Turkey Dip for Muscular Dystrophy, Holiday Food Drive, Disaster Relief Outreach, and the Relay for Life. Recent ...
RNA-targeting small molecule drugs
Ataluren is in clinical trials for the treatment of Duchenne Muscular Dystrophy (DMD). It is believed that Ataluren acts by ... Disney and colleagues provided the first small molecules that targeted r(CUG) repeats in animals models by using rational ... In myotonic dystrophy type 1 (DM1), r(CUG)exp mRNAs sequester proteins including the alternative splicing regulator MBNL1 into ... Branaplam is currently in phase I/II clinical trial for the treatment of Spinal Muscular Atrophy (SMA). This molecule is from a ...
It was researched for the treatment of muscular dystrophy but was not successful in human clinical trials, though it has ... reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not ... Satoyoshi E (July 1992). "Therapeutic trials on progressive muscular dystrophy". Internal Medicine. 31 (7): 841-6. doi:10.2169/ ...
Duchenne de Boulogne
Duchenne Muscular Dystrophy, Duchenne-Aran spinal muscular atrophy, Duchenne-Erb paralysis, Duchenne's disease (Tabes dorsalis ... Darwin's The Expression of the Emotions in Man and Animals written, in part, as a refutation of Sir Charles Bell's ... Duchenne muscular dystrophy Erb-Duchenne palsy Duchenne-Aran disease acute poliomyelitis Functional electrical stimulation as a ... He is also credited with the discovery of Duchenne muscular dystrophy. Duchenne died in 1875, after several years of illness. ...
Sex differences in human physiology
Duchenne Muscular Dystrophy X-linked agammaglobulinaemia X-linked ichythyosis Becker muscular dystrophy Non-specific X-linked ... The brains of humans, like many animals, are slightly different for males and females. Early research into the differences ... The greater muscle mass is reported to be due to a greater capacity for muscular hypertrophy as a result of higher levels of ... the closest animal relative. A separate study was done on one-day-old infants to see if infants diverted attention differently ...
... who are working to find a cure for Duchenne muscular dystrophy, a fatal genetic disease. In Taussig's fiction, common ... Thoughts on Humans and Other Animals, the book, amongst other things, "renders the barriers that we erect between our species ...
Arthropods in culture
The peptide GsMtx-4, found in the venom, has been studied for possible use in cardiac arrhythmia, muscular dystrophy, and ... William Parsons, 3rd Earl of Rosse drew the Crab Nebula in 1848 and noticed its similarity to the animal; the Crab pulsar lies ... In South Africa and South Asia, the scorpion is a significant animal culturally, appearing as a motif in art, especially in ... The arthropods are a phylum of animals with jointed legs; they include the insects, arachnids such as spiders, myriapods, and ...
... , sold under the brand name Vyondys 53, is a medication used for the treatment of Duchenne muscular dystrophy (DMD) ... In animal studies, no significant changes were seen in the male reproductive system of monkeys and mice following weekly ... "FDA grants accelerated approval to first targeted treatment for rare Duchenne muscular dystrophy mutation". U.S. Food and Drug ... Golodirsen is indicated for the treatment of Duchenne muscular dystrophy (DMD) in pediatric patients who have a confirmed ...
In 2010, early clinical trials for the treatment of Friedreich's ataxia and Duchenne muscular dystrophy have been completed. As ... Positive effects on the energy household of mitochondria has also been observed in animal models. Clinical relevance of these ... Clinical trial number NCT01027884 for "Phase III Study of Idebenone in Duchenne Muscular Dystrophy (DMD) (DELOS)" at ... "Efficacy and Tolerability of Idebenone in Boys With Cardiac Dysfunction Associated With Duchenne Muscular Dystrophy (DELPHI)" ...
Limb-girdle muscular dystrophy
The review goes on to state that animal models for LGMD2 have been used to analyse therapeutic medications. Also adding that ... Limb-girdle muscular dystrophy or (LGMD) is a genetically and clinically heterogeneous group of rare muscular dystrophies. It ... "limb-girdle muscular dystrophy". Genetics Home Reference. Retrieved 2016-04-22. "Limb-Girdle Muscular Dystrophy: Practice ... "Limb-girdle muscular dystrophy". "Limb-Girdle Muscular Dystrophy Treatment & Management: Medical Care, Surgical Care, ...
Finnish heritage disease
Tibial muscular dystrophy, tardive Usher syndrome, type 3A Out of these, three are rare causes of dwarfism: cartilage-hair ... presumably when populations practicing agriculture and animal husbandry arrived in Finland. In Finland about one in five ... Finnish and Norwegian type Mulibrey nanism Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), ...
Americans with Disabilities Act of 1990
... muscular dystrophy, major depressive disorder, bipolar disorder, post-traumatic stress disorder, obsessive compulsive disorder ... Businesses are allowed to ask if the animal is a service animal and ask what tasks it is trained to perform, but they are not ... or the animal is a direct threat to people's health and safety. Allergies and fear of animals would not be considered a threat ... In this case, businesses that prepare or serve food are not required to provide care or food for service animals, nor do they ...
List of skin conditions
... simplex of Ogna Epidermolysis bullosa simplex with mottled pigmentation Epidermolysis bullosa simplex with muscular dystrophy ... Acral lentiginous melanoma Amelanotic melanoma Animal-type melanoma Desmoplastic melanoma (neurotropic melanoma, spindled ... Median nail dystrophy (dystrophia unguis mediana canaliformis, median canaliform dystrophy of Heller, solenonychia) Mees' lines ... congenital fascial dystrophy) Neurocutaneous conditions are due organic nervous system disease or are psychiatric in etiology. ...
Spinal muscular atrophy (SMA), muscular dystrophies, cystic fibrosis, Long QT syndrome, and Type I diabetes. The potentially ... Human cell types in a dish provide an alternative to traditional preclinical assays using animal, human immortalized cells or ... "Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy" (PDF). Nature Biotechnology. 33 ... For example, motoneurons are used to study spinal muscular atrophy (SMA) and cardiomyocytes are used to study arrythmia. This ...
The race was first run in 1927, and benefits muscular dystrophy research as well as over a dozen other charities. The ... The museum's permanent collection includes small live animals. The Old Manchester Museum, focusing on local history, is ...
Facioscapulohumeral muscular dystrophy - even though there is not a clear correlation between the facioscapulohumeral muscular ... Afterwards the animal will show a complete repulsion to the food. The animal reacts to food as if it is bitter or foul. Mixed ... Animals in this study also demonstrated several other types of eating behaviour: "weak eating," in which the animal slowly ... Stübgen, J (2008). "Facioscapulohumeral Muscular Dystrophy: A Radiologic and Manometric Study of the Pharynx and Esophagus" ( ...
Muscle atrophy is the result of various causes, including aging, disuse, denervation, muscular dystrophy, cachexia and ... It is also known as the 'common shoulder muscle', particularly in other animals such as the domestic cat. Anatomically, it ...
List of diseases (O)
... facial clefts Oculomelic amyoplasia Oculomotor nerve palsy Oculopalatoskeletal syndrome Oculopharyngeal muscular dystrophy ... animals, insects and fungi Occupational asthma - chemicals and materials Occupational asthma - drugs and enzymes Occupational ... dominant Oculodentoosseous dysplasia recessive Oculodigitoesophagoduodenal syndrome Oculo-gastrointestinal muscular dystrophy ...
... muscular dystrophy and Down's syndrome. Yeung has won four R&D 100 Awards and an Editor's Choice award from R&D Magazine for ... animal waste, and garbage. Discovery of a boron-aluminum-magnesium ceramic alloy that exhibits exceptional hardness. Adding a ...
List of women in mathematics
... studies protein interactions in muscular dystrophy Sally Elizabeth Carlson (1896-2000), first woman to obtain a doctorate in ... American historian of mathematics and expert on Marie Curie and human-animal relations Martine Queffélec (born 1949), French ...
Index of anatomy articles
... multifidus muscle muscle fascicle muscle spindle muscle tissue muscles of the thorax muscular atrophy muscular system muscular ... anatomical terms of location anatomical terms of motion anatomy anconeus angiography angiology angular gyrus anhidrosis animal ... mylohyoid groove mylohyoid line mylohyoid muscle mylohyoid nerve myocardium myocyte myology myotome myotonia myotonic dystrophy ... nucleus succus sulcus sulcus limitans superciliary arch superciliary line superficial cervical muscle superficial muscular ...
In his laboratory, his research on muscular dystrophy indicated to him that the disease is one that affects all the cells of ... came to this conclusion by comparing amyloid beta peptide in an animal model to the same compound in humans. Later, he was ... Runyon, Keith (March 14, 1976). "New theory on muscular dystrophy is studied". The Courier-Journal. Retrieved April 20, 2021 - ... He continued his research on dystrophy from Duke as an assistant professor of chemistry. ...
Prostanoid Receptor as a Potential Therapy for Cardiomyopathy of Muscular Dystrophy". Journal of the American Heart Association ... It has been studied in animal models for the treatment of myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy ...
Martin also made a public reconciliation with Lewis on his partner's Labor Day telethon, benefiting the Muscular Dystrophy ... The Animal in Hollywood: Anthony Fiato's Life in the Mafia. Barricade Books, New York, 1998. ISBN 1-56980-126-6 Biography ...
Coppola was diagnosed with muscular dystrophy in her early 20s. She grew up in Hamden, Connecticut and graduated cum laude with ... citation needed] Animals We Keep in the City (Zeitgeist Press, 1989) Invisible Men's Voices (Blue Beetle, 1992) As Luck Would ... Coppola published five chapbooks of her poetry; Animals We Keep in the City (Zeitgeist Press, 1989), Invisible Men's Voices ( ...
... deletion of dystroglycan causes long-term potentiation impairment and developmental abnormalities similar to muscular dystrophy ... Members of the neurexin family are found across all animals, including basal metazoans such as porifera (sponges), cnidaria ( ...
... and muscular dystrophy, had been deliberately hidden from the public by the Food and Drug Administration, the Federal Trade ... Trudeau's books claim that animals in the wild rarely develop degenerative conditions like cancer or Alzheimer's disease, and ...
Genetic Engineering of Dystroglycan in Animal Models of Muscular Dystrophy
... Francesca Sciandra,1 Maria Giulia Bigotti,2 Bruno ... L. S. Steffen, J. R. Guyon, E. D. Vogel et al., "Zebrafish orthologs of human muscular dystrophy genes," BMC Genomics, vol. 8, ... L. E. Lim, F. Duclos, O. Broux et al., "β-Sarcoglycan: characterization and role in limb-girdle muscular dystrophy linked to ... R. D. Cohn and K. P. Campbell, "Molecular basis of muscular dystrophies," Muscle & Nerve, vol. 23, no. 10, pp. 1456-1471, 2000. ...
Mice Holding Back Muscular Dystrophy Research?: An All Creatures Animal Rights Article
This includes both human and non-human animals, but not all of them can speak for themselves ... Mice Holding Back Muscular Dystrophy Research? - All of Gods creatures have rights, a fact that most people dont seem to ... Mice Holding Back Muscular Dystrophy Research?. From all-creatures.org. Animal Rights Articles ... Mice Holding Back Muscular Dystrophy Research?. From ScienceDaily.com. December 2009. Humans and mice have previously unknown ...
Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal model | EurekAlert! Science News
... and reverses the process of muscle-wasting found in muscular dystrophy. ... Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal model The gene therapy was able to ... Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal model. University of Washington ... National Institutes of Health, Muscular Dystrophy Association, Bruce and Jolene McCaw. Keywords. *BIOCHEMISTRY ...
SOPs for Duchenne Animal Models - Parent Project Muscular Dystrophy
Animal Models for Muscular Dystrophy Show Different Patterns of Sarcolemmal Disruption | JCB
Using tracer molecules, we compared sarcolemmal integrity in animal models for muscular dystrophy and in muscular dystrophy ... congenital muscular dystrophy. DGC. dystrophin-glycoprotein complex. DMD. Duchenne muscular dystrophy. EBD. Evans blue dye. H&E ... Animal Models for Muscular Dystrophy Show Different Patterns of Sarcolemmal Disruption. Volker Straub, Jill A. Rafael, Jeffrey ... Animal Models for Muscular Dystrophy Show Different Patterns of Sarcolemmal Disruption. Volker Straub, Jill A. Rafael, Jeffrey ...
p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy | Disease Models & Mechanisms
p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy ... p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy ... p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy ... p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy ...
Clinically Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular...
Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular Dystrophy. ... Facioscapulohumeral muscular dystrophy (FSHD) is characterized by misexpression of the double homeobox 4 (DUX4) developmental ... Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular Dystrophy ... SIGNIFICANCE STATEMENT Facioscapulohumeral muscular dystrophy (FSHD) currently has no treatment options. This work provides ...
Challenges for gene transfer to the respiratory muscles lessons from animal models - Muscular Dystrophy
Duchenne Muscular Dystrophy Becker Muscular Dystrophy Limb-Girdle Muscular Dystrophy Myotonic Dystrophy ... Facioscapulohumeral Muscular Dystrophy Congenital Muscular Dystrophy Metabolic Diseases of Muscle Acid Maltase Deficiency ... Last Updated on Wed, 06 Apr 2016 , Muscular Dystrophy Table 3.1 shows a list of some of the more common or prototypical ... Table 3.1 Neuromuscular Disorders Affecting Respiratory Muscle Function Muscular Dystrophies. ...
End Breeding of Dogs with Muscular Dystrophy for Animal Testing at French Veterinary School - ForceChange
Muscular Dystrophy | Animal Genetics
Animal Genetics provides genetic testing services for animals including Avian DNA sexing and diseases and inherited Canine and ... Animal Genetics offers DNA testing for Muscular Dystrophy. The genetic test verifies the presence of the X-linked Muscular ... The dog carries two copies of the mutant gene and is homozygous for Muscular Dystrophy. The dog is affected by Muscular ... Muscular Dystrophy. Description:. GRMD is a mutation of the dystrophin gene that causes a deficiency of dystrophin proteins in ...
Muscle satellite cells and impaired late stage regeneration in different murine models for muscular dystrophies | Scientific...
In muscular dystrophies, however, a failure of the regenerative process results in muscle degeneration and weakness. To analyze ... in an animal model of muscular dystrophy. Biochim Biophys Acta 1573, 216-224 (2002). ... A model for Congenital muscular dystrophy type 1D is the myodystrophy Largemyd mouse, which harbors a mutation in the Large1 ... A good genetic and biochemical model for Duchenne muscular dystrophy is the Dmdmdx mouse that bears a nonsense point mutation ...
IFN-γ Promotes Muscle Damage in the mdx Mouse Model of Duchenne Muscular Dystrophy by Suppressing M2 Macrophage Activation and...
All animals were handled according to guidelines approved by the Chancellors Animal Research committee at the University of ... particularly in Duchenne muscular dystrophy (DMD) and the mdx mouse model of DMD. Although DMD and mdx dystrophies are caused ... 1) of muscular dystrophy by comparing IFN-γ−/−/mdx mice to mdx background strain controls (Fig. 2). Fluorescence intensity of ... Muscular dystrophy in the mdx mouse: histopathology of the soleus and extensor digitorum longus muscles. J. Neurol. Sci. 80: 39 ...
Gene Therapy Found to be Effective in Improving Muscle Strength in Animal Model of Fatal Muscle Disease
... and large-animal models and published in the journal Science Translational Medicine suggests that gene therapy can be used in ... Myotonic Dystrophy. Detailed information on myotonic muscular dystrophy, a common form of muscular disease that affects adults ... Muscular Dystrophy. Overview about muscular dystrophy, a muscle disease characterized by muscle weakness and muscle wasting. ... These results demonstrate the efficacy of gene replacement therapy for myotubular myopathy in animal models and pave the way to ...
Molecular and Cell Biology of Muscular Dystrophy | T. Partridge | Springer
Molecular and Cell Biology of Muscular Dystrophy gives a series of accounts of various aspects of the remarkable breakthrough ... Life Sciences Animal Sciences Molecular and Cell Biology of Human Diseases Series Free Preview ... Molecular and Cell Biology of Muscular Dystrophy. Editors. * T. Partridge Series Title. Molecular and Cell Biology of Human ... Molecular and Cell Biology of Muscular Dystrophy gives a series of accounts of various aspects of the remarkable breakthrough ...
Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy | Springer for Research & Development
Animals and AON injections. All experiments were performed with 5-6 weeks old mdx mice under the approval of the Animal ... Duchenne Muscular Dystrophy Duchenne Muscular Dystrophy Duchenne Muscular Dystrophy Patient Myogenic Regulatory Factor MSTN ... By contrast, Duchenne muscular dystrophy (DMD) is characterized by a loss of muscle fibers and impaired regeneration. In this ... Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disorder, which is caused by dystrophin deficiency in ...
Petition · Keep the DMD Golden Retriever research at Texas A&M - Cure Duchenne Muscular Dystrophy · Change.org
Animal Lover needs your help with "Keep the DMD Golden Retriever research at Texas A&M - Cure Duchenne Muscular Dystrophy". ... Animal Lover needs your help with "Keep the DMD Golden Retriever research at Texas A&M - Cure Duchenne Muscular Dystrophy". ... Duchenne Muscular Dystrophy (DMD) is a fatal genetic disorder affecting mostly boys. Boys with DMD typically lose the ability ... Kornegay to remove the colony of Duchenne Muscular Dystrophy (DMD) golden retrievers from Texas A&M by January 2018, allegedly ...
Duchenne muscular dystrophy - University of Portsmouth
Animal welfare. *Facts and figures. *Benefits of animal research *Duchenne muscular dystrophy ... Professor Gorecki says: "If we can achieve improvement in the mouse model of Duchenne muscular dystrophy, then there is a good ... Absence of this protein causes a debilitating and incurable Duchenne muscular dystrophy. ... the most common and severe of all muscular dystrophies.. The condition is caused by a lack of dystrophin, a protein which acts ...
Trial of Gene Therapy for Duchenne Muscular Dystrophy Put on Hold | The Scientist Magazine®
See "Severe Toxicity Reported in High-Dose AAV Gene Therapy in Animals". Catherine Offord is an associate editor at The ... Duchenne muscular dystrophy. gene therapy. genetics & genomics. Muscular Dystrophy. nutshell. pharma & biotech. side effects. ... Trial of Gene Therapy for Duchenne Muscular Dystrophy Put on Hold. The US Food and Drug Administration halts a study by Solid ... A clinical trial of a gene therapy for Duchenne muscular dystrophy has been halted after a patient suffered serious side ...
Antibody therapy of cancer | Nature Reviews Cancer
CPP-directed oligonucleotide exon skipping in animal models of Duchenne muscular dystrophy. - Department of Paediatrics
The leading example is Duchenne muscular dystrophy (DMD), a fatal muscle degenerative disease, where AO-mediated skipping of ... leading to the production of functional dystrophin protein and ameliorate the DMD phenotype in animal models. Clinical proof-of ... as having significant potential for systemic delivery and therapeutic correction in DMD animal models. Here, we review the ... experimental protocols used in studies aimed at investigating CPP-conjugated AOs as systemic splice correcting agents in animal ...
Sensitive dystrophin protein quantification in porcine animal model of Duchenne muscular dystrophy after exon skipping
Using electromyography to assess function in humans and animal models of muscular dystrophy<...
Using electromyography to assess function in humans and animal models of muscular dystrophy. / Han, Jay J.; Carter, Gregory T ... Using electromyography to assess function in humans and animal models of muscular dystrophy. Physical Medicine and ... title = "Using electromyography to assess function in humans and animal models of muscular dystrophy", ... T1 - Using electromyography to assess function in humans and animal models of muscular dystrophy ...
TNF-α-Induced microRNAs Control Dystrophin Expression in Becker Muscular Dystrophy
The amount and distribution of dystrophin protein in myofibers and muscle is highly variable in Becker muscular dystrophy and ... in exon-skipping trials for Duchenne muscular dystrophy. Here, we investigate a molecular basis for this variability. In muscle ... and muscle is highly variable in Becker muscular dystrophy and in exon-skipping trials for Duchenne muscular dystrophy. Here, ... TNF-α-Induced microRNAs Control Dystrophin Expression in Becker Muscular Dystrophy Cell Rep. 2015 Sep 8;12(10):1678-90. doi: ...
Basic fibroblast growth factor promotes in vivo muscle regeneration in murine muscular dystrophy
Muscular Dystrophy | SpringerLink
With the molecular mechanisms underlying the various forms of muscular dystrophy now rapidly clarifying, precise diagnosis has ... Also discussed are the use of animal models to understand human muscular dystrophy and the available options for gene-based ... The various DNA techniques focus on both the X-linked muscular dystrophies and the autosomal recessive muscular dystrophies. ... In Muscular Dystrophy: Methods and Protocols, Katherine Bushby and Louise Anderson have assembled an outstanding collection of ...
A few animal models of Duchenne muscular dystrophy (DMD) are available | Thioredoxin Reductase and its Inhibitors
A few animal models of Duchenne muscular dystrophy (DMD) are available. Posted by Maurice Prescott on May 8, 2017 ... A few animal models of Duchenne muscular dystrophy (DMD) are available large ones such as pigs or dogs being expensive and ... Materials and Methods Animals This study was approved by the Ethics Committee on Animal SB-505124 Experimentation of the Pays ... Although each animal model has its own limitations they have all been essential for the development of treatment strategies SB- ...
RFA-AR-13-012: Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers (U54)
Wellstone Muscular Dystrophy Cooperative Research Centers (U54) RFA-AR-13-012. NIAMS ... Vertebrate Animals. The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment ... dystrophy. One provision of the MD-CARE Act was that the NIH establish centers of excellence for research on muscular dystrophy ... dystrophy, the MDCRCs are expected to play leadership roles in training of new researchers for the muscular dystrophy field and ...
Laurel Hamers, Author at Science News
CRISPR gene editing relieves muscular dystrophy symptoms in dogs Scientists have used CRISPRs molecular scissors in beagle ... Animals Naked mole-rats eat the poop of their queen for parenting cues Hormones in the naked mole-rat queens poop turn ... Animals Silver-backed chevrotains have been rediscovered by science after 29 years By Jonathan Lambert. 6 hours ago. ... Animals Manta rays have an unusual mouth filter that resists clogging Manta rays filter feed differently than other ocean ...
A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces...
Animals. Apoptosis / physiology*. Caveolae / metabolism. Caveolin 3. Caveolins / genetics*, metabolism. Cells, Cultured. ... lead to a form of autosomal dominant muscular dystrophy referred to as limb girdle muscular dystrophy type 1C (LGMD-1C). One of ... Muscular Dystrophies / genetics*, metabolism. Myoblasts / metabolism. Signal Transduction. src-Family Kinases / metabolism*. ... A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces ...
Forms of muscularMiceCongenitalType of muscular dystrophyParent Project Muscular DystrophyTreat Duchenne muscularSkeletalBeckerForm of muscular dystrophyMouse Model of Duchenne MuscularGeneticLimb-Girdle Muscular DystrophiesPeople with Duchenne muscularChildren with Duchenne muscularScreening for Duchenne muscularPathologyDuchenne Muscular DystrophyGene therapy of Duchenne dystrophyProteinsHeterogeneousTreatment of Muscular DystrophyGolden retrieversHuman Muscular DystrophyExonAutosomal dominantModelsGeneticsPatients with myotonic dystrophyCauses myotonic dystrophyMutations in the dystrophin geneRecessiveSevereFacioscapulohumeralMusclesProteinDiseasesDystrophin ExpressionCanineGeneticallyMyotonic Dystrophy TypeClinicalMuscle degenerationMyopathySymptomsCommon form of muscularDisordersDegenerationPathogenesisModelHereditaryLack dystrophinResearch
Forms of muscular10
- Genetic defects in a number of components of the dystrophin-glycoprotein complex (DGC) lead to distinct forms of muscular dystrophy. (rupress.org)
- Defects in components of the dystrophin-glycoprotein complex (DGC) are responsible for different forms of muscular dystrophies. (nature.com)
- With the molecular mechanisms underlying the various forms of muscular dystrophy now rapidly clarifying, precise diagnosis has become a reality, and even a requirement in clinical practice. (springer.com)
- Mutations in members of the dystrophin-glycoprotein complex (DGC) account for several forms of muscular dystrophy and cardiomyopathy ( Heydemann and McNally, 2007 ). (frontiersin.org)
- Mutations in many protein components of DGC (such as dystrophin, sarcoglycans or dystroglycans) lead to various forms of muscular dystrophy and murine models with various dystrophic phenotypes, partly because certain components of DGC are more crucial in function than others [ 7 ]. (iospress.com)
- In both cats and dogs, the most common forms of muscular dystrophy begin at birth or shortly thereafter. (petcarerx.com)
- Most forms of muscular dystrophy in both cats and dogs appear very young. (petcarerx.com)
- Responses to this program announcement may include studies in appropriate animal models or preclinical or clinical studies in patients with facioscapulohumeral dystrophy (FSH), limb-girdle muscular dystrophy (LGMD), myotonic dystrophy, congenital muscular dystrophy (CMD), Emery-Dreifuss muscular dystrophy (EMD), Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or other forms of muscular dystrophy. (nih.gov)
- Precise incidence and prevalence figures are difficult to determine, and most individual forms of muscular dystrophy are rare. (nih.gov)
- Although genes responsible for many forms of muscular dystrophy have been identified, much more research is needed to discover the pathogenic mechanisms involved and develop effective treatments. (nih.gov)
- Mice Holding Back Muscular Dystrophy Research? (all-creatures.org)
- Humans and mice have previously unknown and potentially critical differences in one of the genes responsible for Duchenne muscular dystrophy (DMD). (all-creatures.org)
- Researchers writing in the open access journal BMC Biology have found that two major features of a key DMD gene are present in most mammals, including humans, but are specifically absent in mice and rats, calling into question the use of the mouse as the principal model animal for studying DMD. (all-creatures.org)
- Roberts said, 'Two previously unrecognized features (a gene switch or promoter and a novel binding site for the adaptor protein syntrophin) are encoded by the α-dystrobrevin gene of almost all four-legged animals except mice. (all-creatures.org)
- The mice show a whole body effect, with a dramatic improvement of their dystrophy. (eurekalert.org)
- The results involved mice, so researchers do not know if the method will work in larger animals or people. (eurekalert.org)
- In contrast, mdx mice, a dystrophin-deficient animal model for Duchenne muscular dystrophy, showed significant Evans blue accumulation in skeletal muscle fibers. (rupress.org)
- Researchers at Johns Hopkins have shown that a drug commonly used to lower blood pressure reverses muscle wasting in genetically engineered mice with Marfan syndrome and also prevents muscle degeneration in mice with Duchenne muscular dystrophy. (hopkinsmedicine.org)
- Modified stem cells have been used to treat Duchenne muscular dystrophy (DMD) in mice by replacing the faulty gene that causes the disease with a normal version of the gene. (understandinganimalresearch.org.uk)
- The first transgenic livestock were produced in 1985  and the first animal to synthesise transgenic proteins in their milk were mice,  engineered to produce human tissue plasminogen activator in 1987. (wikipedia.org)
- The researchers used two animal models: mice with an engineered MTM1 mutation and dogs carrying a naturally occurring MTM1 gene mutation. (medicalxpress.com)
- CureDuchenne , a patient charity based in Newport Beach, California, says it will spend $5 million to finance a new startup company, Exonics Therapeutics , based on research in which scientists cured mice of muscular dystrophy by altering the DNA letters inside their cells. (technologyreview.com)
- Exonics will advance research underway at the University of Texas Southwestern Medical Center, where scientist Eric Olson and colleagues have cured mice of muscular dystrophy using CRISPR, stirring intense hopes among patients. (technologyreview.com)
- This finding was confirmed on mRNA and protein levels in two additional dysferlin-deficient mouse strains, A/J mice and Dysf −/− mice, as well as in patients with dysferlin-deficient muscular dystrophy. (jimmunol.org)
- All these mice develop progressive muscular dystrophy after 2 mo of age. (jimmunol.org)
- Mice are often used as animal models of various human neuromuscular diseases, and analysis of these models often requires detailed gait analysis. (frontiersin.org)
- Many of the neuromuscular diseases that are studied using mice as a model organism, such as Duchenne Muscular Dystrophy (DMD) and Amyotrophic Lateral Sclerosis (ALS), are known to severely affect gait. (frontiersin.org)
- Both strains of mice show symptoms similar to myotonic dystrophy. (redorbit.com)
- Despite showing less intense myofibrosis and scarce deposition of fatty tissue, mdx mice are considered an adequate animal model for studies on the pathogenesis of Duchenne-type muscular dystrophy. (scielo.br)
- Therefore mdx mice should be regarded as an important tool for studies on pathogenetic mechanisms of Duchenne-type muscular dystrophy. (scielo.br)
- 7. Dupont-Versteegden EE, McCarter RJ, Katz MS. Voluntary exercise decreases progression of muscular dystrophy in diaphragm of mdx mice J Appl Physiol 1994;77:1736-1741. (scielo.br)
- These same cells, injected into mice with a mild form of muscular dystrophy, formed healthy, functional muscle fibers at the site of deteriorating tissue. (technologyreview.com)
- Researchers from the University of Pittsburgh report the first study to achieve success with gene therapy for the treatment of congenital muscular dystrophy (CMD) in mice, demonstrating that the formidable scientific challenges that have cast doubt on gene therapy ever being feasible for children with muscular dystrophy can be overcome. (innovations-report.com)
- While we have much farther to go until we can say gene therapy will work in children, we have shown here a glimmer of hope by presenting the first evidence of a successful gene therapy approach that improved both the general health and longevity in mice with congenital muscular dystrophy," said Dr. Xiao. (innovations-report.com)
- Mutations in the laminin α 2-chain gene ( LAMA2 ) cause merosin-deficient congenital muscular dystrophy," Nature Genetics , vol. 11, no. 2, pp. 216-218, 1995. (hindawi.com)
- L. Wells, "The O -mannosylation pathway: glycosyltransferases and proteins implicated in congenital muscular dystrophy," The Journal of Biological Chemistry , vol. 288, no. 10, pp. 6930-6935, 2013. (hindawi.com)
- LARGE can functionally bypass α -dystroglycan glycosylation defects in distinct congenital muscular dystrophies," Nature Medicine , vol. 10, no. 7, pp. 696-703, 2004. (hindawi.com)
- We furthermore assessed Evans blue incorporation in skeletal muscle of the dystrophia muscularis ( dy / dy ) mouse and its milder allelic variant, the dy 2J / dy 2J mouse, animal models for congenital muscular dystrophy. (rupress.org)
- Taken together, these results suggest that the pathogenic mechanisms in congenital muscular dystrophy are different from those in Duchenne muscular dystrophy, although the primary defects originate in two components associated with the same protein complex. (rupress.org)
- A model for Congenital muscular dystrophy type 1D is the myodystrophy Large myd mouse, which harbors a mutation in the Large1 gene. (nature.com)
- A new study conducted on small- and large-animal models and published in the journal Science Translational Medicine suggests that gene therapy can be used in improving muscle strength among patients of a fatal congenital pediatric disease known as X-linked myotubular myopathy. (medindia.net)
- Congenital muscular dystrophy (CMD) is a family of muscle disorders which present clinically as lack of muscle tone at birth, joint stiffness and contractures, markedly delayed motor development, slowly progressive weakness, and muscle atrophy. (kzoo.edu)
- Ullrich syndrome is a recessive congenital muscular dystrophy affecting connective tissue and muscle. (pnas.org)
- Congenital muscular dystrophy (CMD) identifies a heterogeneous group of disorders characterized by muscle weakness and hypotonia at birth, with a muscle pathology reminiscent of muscular dystrophy. (pnas.org)
- Preclinical studies show that gene therapy can improve muscle strength in small- and large-animal models of a fatal congenital pediatric disease known as X-linked myotubular myopathy. (medicalxpress.com)
Type of muscular dystrophy6
- It is the most common type of muscular dystrophy . (fda.gov)
- Several different proteins can be affected, and the specific protein that is absent or defective identifies the specific type of muscular dystrophy. (wikipedia.org)
- The diagnosis of limb-girdle muscular dystrophy can be done via muscle biopsy , which will show the presence of muscular dystrophy, and genetic testing is used to determine which type of muscular dystrophy a patient has. (wikipedia.org)
- The work not only opens up potential therapies for this type of muscular dystrophy, but also paves the way for RNA-targeted therapeutics in general. (scripps.edu)
- WASHINGTON, February 11, 2020 -- Duchenne muscular dystrophy is the most common type of muscular dystrophy, affecting more than 10,000 males at birth per year in the United States with severe physical disability, chronic wasting and muscle deterioration. (brightsurf.com)
- The total impact, however, is high, as tens of thousands of people are affected with some type of muscular dystrophy in the United States alone. (nih.gov)
Parent Project Muscular Dystrophy1
- With the approval of VYONDYS 53, up to another 8% of Duchenne families will have a therapy to treat this devastating disease," said Pat Furlong, founding president and chief executive officer, Parent Project Muscular Dystrophy (PPMD). (einpresswire.com)
Treat Duchenne muscular3
- The U.S. Food and Drug Administration today granted accelerated approval to Vyondys 53 (golodirsen) injection to treat Duchenne muscular dystrophy (DMD) patients who have a confirmed mutation of the dystrophin gene that is amenable to exon 53 skipping. (fda.gov)
- PHILADELPHIA--A gene therapy being developed at Penn Medicine to treat Duchenne muscular dystrophy (DMD) successfully and safely stopped the severe muscle deterioration associated with the rare, genetic disease in both small and large animal models, according to a first-of-its-kind study from Penn Medicine researchers. (eurekalert.org)
- A gene therapy being developed to treat Duchenne muscular dystrophy (DMD) successfully and safely stopped the severe muscle deterioration associated with the rare, genetic disease in both small and large animal models. (genengnews.com)
- A good genetic and biochemical model for Duchenne muscular dystrophy is the Dmd mdx mouse that bears a nonsense point mutation in exon 23 of the Dmd gene, which causes lack of this protein in skeletal muscle. (nature.com)
- A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes. (biomedsearch.com)
- In patients suffering from muscular dystrophy, the skeletal muscle already starts to weaken in childhood. (eurekalert.org)
- Although dysferlin is expressed in human skeletal and cardiac muscles ( 1 ), mutations in the encoding gene ( DYSF ) lead only to skeletal muscle phenotypes without myocardial involvement, namely limb girdle muscular dystrophy 2B (LGMD2B) 4 and Miyoshi myopathy ( 4 ). (jimmunol.org)
- MDA awarded $352,188 to Zolt Arany, assistant professor in medicine at Beth Israel Deaconess Medical Center, part of Harvard Medical School in Boston, for research into the role of skeletal muscle metabolism in Duchenne muscular dystrophy (DMD) . (mda.org)
- Molecular and Cell Biology of Muscular Dystrophy gives a series of accounts of various aspects of the remarkable breakthrough which has been achieved in our understanding of the Duchenne/Becker muscular dystrophies and of the consequences and ramifications of this breakthrough. (springer.com)
- Patients with such mutations develop the less severe Becker muscular dystrophy. (springer.com)
- The amount and distribution of dystrophin protein in myofibers and muscle is highly variable in Becker muscular dystrophy and in exon-skipping trials for Duchenne muscular dystrophy. (nih.gov)
- The molecular basis for Duchenne versus Becker muscular dystrophy: correlation of severity with type of deletion," American Journal of Human Genetics , vol. 45, no. 4, pp. 498-506, 1989. (hindawi.com)
Form of muscular dystrophy5
- The disease is similar to the human form of muscular dystrophy. (horsetesting.com)
- Merosin deficient CMD is a more severe, newly discovered autosomal recessive form of muscular dystrophy, whose patients have all CMD hallmark symptoms, but additionally are unable to walk independently. (kzoo.edu)
- Myotonic dystrophy type 1 is the most common form of muscular dystrophy in adults, affecting one in 8,000 people in North America. (innovations-report.com)
- However, not all of the cells turned into muscle, and when the team injected the solution into a mouse with a mild form of muscular dystrophy, the mixture caused tumors to form. (technologyreview.com)
- Myotonic dystrophy is the most common form of muscular dystrophy in adults. (nih.gov)
Mouse Model of Duchenne Muscular1
- Professor Gorecki says: "If we can achieve improvement in the mouse model of Duchenne muscular dystrophy, then there is a good chance that the same treatment may work in human patients, though of course, it will still need to be tested in clinical trials. (port.ac.uk)
- Duchenne muscular dystrophy is an X-linked genetic disorder that strikes one of every 3,500 newborn boys. (eurekalert.org)
- Facioscapulohumeral muscular dystrophy (FSHD) affects over 25,000 people in the USA alone, making it one of the most prevalent genetic diseases. (biologists.org)
- Muscular dystrophies are a heterogeneous group of genetic diseases that cause a progressive loss of motor ability. (nature.com)
- Duchenne Muscular Dystrophy (DMD) is a fatal genetic disorder affecting mostly boys. (change.org)
- Scientists have used CRISPR's molecular scissors in beagle puppies to repair a genetic mutation that causes muscular dystrophy. (sciencenews.org)
- The 2014 Evidence-based guideline summary: Diagnosis and treatment of limb-girdle and distal dystrophies indicates that individuals suspected of having the inherited disorder should have genetic testing. (wikipedia.org)
- Following a genomic analysis of all patients, the researchers chose one family because of their particular form of the disease: Limb-girdle muscular dystrophy 2D/R3 is relatively common, progresses rapidly, and has a suitable docking site for the "genetic scissors" close to the mutation on the DNA. (eurekalert.org)
- Myotonic dystrophy type 1 involves a type of RNA defect known as a "triplet repeat," a series of three nucleotides repeated more times than normal in an individual's genetic code. (scripps.edu)
- Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder characterized by progressive muscle degeneration. (iospress.com)
- Research on the genetic defect that causes myotonic muscular dystrophy has revealed that the mutation disrupts an array of metabolic pathways in muscle cells through its effects on two key proteins. (redorbit.com)
- The most well known, Duchenne muscular dystrophy, is caused by a genetic mutation that disrupts the formation of dystrophin, an important protein involved in the formation of muscle cells. (technologyreview.com)
- Muscular dystrophy is a genetic disorder that deteriorates the muscles of dogs and cats because of low amounts of dystrophin. (petcarerx.com)
- Muscular dystrophy is a type of genetic disease that dogs, cats, humans, and a few other species can get. (petcarerx.com)
Limb-Girdle Muscular Dystrophies2
People with Duchenne muscular2
- Professor of Molecular Medicine, Darek Gorecki , and his team in the School of Pharmacy and Biomedical Sciences , are working to find a treatment that will delay the onset and slow down the progression of muscle degeneration in people with Duchenne muscular dystrophy, the most common and severe of all muscular dystrophies. (port.ac.uk)
- SGT-001 has been administered to six people so far, and involves the transfer of an engineered version of the dystrophin gene DMD , which is dysfunctional in people with Duchenne muscular dystrophy, using an adeno-associated virus (AAV) as a vector. (the-scientist.com)
Children with Duchenne muscular2
- Gait patterns comparison of children with Duchenne muscular dystrophy to those of control subjects considering the effect of gait velocity. (semanticscholar.org)
- The article, "Quantitative coordination evaluation for screening children with Duchenne muscular dystrophy," is authored by Jian An, Zhiying Xie, Fan Jia, Zhaoxia Wang, Yun Yuan, Jue Zhang and Jing Fang. (brightsurf.com)
Screening for Duchenne muscular1
- The result is a data-infused methodology for screening for Duchenne muscular dystrophy. (brightsurf.com)
- The complexity and importance of interactions between muscle and the immune system for regulating muscle pathology has become increasingly apparent as our understanding of the pathology of muscular dystrophy grows, particularly in Duchenne muscular dystrophy (DMD) and the mdx mouse model of DMD. (jimmunol.org)
- Although DMD and mdx dystrophies are caused by null mutations in the dystrophin gene that encodes a membrane-associated structural protein ( 2 ), and the primary defect causing muscle pathology is a weakened cell membrane ( 3 ), inflammatory cells play major roles in promoting the pathology. (jimmunol.org)
- That information has potential therapeutic importance, because it indicates that regulation of the immune response to dystrophic muscle damage could provide a valuable mechanism for reducing the pathology of muscular dystrophy. (jimmunol.org)
- M1 macrophages can be driven to a state of classical activation by proinflammatory Th1 cytokines, especially IFN-γ, and several findings suggest that IFN-γ activation of mdx muscle macrophages can worsen the pathology of muscular dystrophy. (jimmunol.org)
- Cardiac function in muscular dystrophy associates with abdominal muscle pathology. (semanticscholar.org)
- Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy. (greenmedinfo.com)
Duchenne Muscular Dystrophy1
- Recent evidence from both Duchenne muscular dystrophy patients and animal models suggests that myocardial dysfunction is present before myocardial damage or deficiencies in whole heart function, and that treatment prior to heart failure symptoms may be beneficial. (frontiersin.org)
Gene therapy of Duchenne dystrophy1
- Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy. (nih.gov)
- Limb-girdle muscular dystrophy or ( LGMD ) is a genetically and clinically heterogeneous group of rare muscular dystrophies . (wikipedia.org)
- RESEARCH OBJECTIVES Background The muscular dystrophies are a heterogeneous group of inherited neuromuscular diseases characterized by weakness and wasting of muscles. (nih.gov)
Treatment of Muscular Dystrophy1
- The study, " Non-immunogenic utrophin gene therapy for the treatment of muscular dystrophy animal models " published in Nature Medicine , found that a gene therapy successfully stopped the severe muscle deterioration associated with the disease-without triggering immune responses known to hinder previous therapeutic approaches. (genengnews.com)
- Texas A&M Vet School Dean Green has asked Dr. Kornegay to remove the colony of Duchenne Muscular Dystrophy (DMD) golden retrievers from Texas A&M by January 2018, allegedly due to threats and false propaganda by PETA. (change.org)
- Musician Nikki Sixx has sent a letter on PETA 's behalf urging Texas A&M University (TAMU) to stop breeding golden retrievers and other dogs to have painful and debilitating canine muscular dystrophy and to end its use of dogs in cruel experiments. (blabbermouth.net)
- Although muscular dystrophy is always rare, some breeds, particularly Golden Retrievers , are more at risk than others. (petcarerx.com)
- Dr. Poulton joined forces with us in speaking out against Texas A&M University's (TAMU) use of golden retrievers and other dogs in painful canine muscular dystrophy experiments, in which afflicted dogs struggle to walk, eat, and even breathe. (peta.org)
Human Muscular Dystrophy1
- Also discussed are the use of animal models to understand human muscular dystrophy and the available options for gene-based therapy. (springer.com)
- CPP-directed oligonucleotide exon skipping in animal models of Duchenne muscular dystrophy. (ox.ac.uk)
- To facilitate preclinical testing of promising compounds, we established a novel animal pig model of DMD carrying an exon 52 deletion in the DMD gene and closely mimicking the human phenotype. (exonskipping.eu)
- VYONDYS 53 is an antisense oligonucleotide from Sarepta's phosphorodiamidate morpholino oligomer (PMO) platform, indicated for the treatment of Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation amenable to exon 53 skipping. (einpresswire.com)
- Targeted disruption of exon 52 in the mouse dystrophin gene induced muscle degeneration similar to that observed in duchenne muscular dystrophy," Biochemical and Biophysical Research Communications , vol. 238, no. 2, pp. 492-497, 1997. (hindawi.com)
- Theoretic applicability of antisense-mediated exon skipping for Duchenne muscular dystrophy mutations," Human Mutation , vol. 30, no. 3, pp. 293-299, 2009. (hindawi.com)
- Several mutations in the muscle-specific caveolin, caveolin-3, lead to a form of autosomal dominant muscular dystrophy referred to as limb girdle muscular dystrophy type 1C (LGMD-1C). (biomedsearch.com)
- Stepanov, V. 2016-04-13 00:00:00 Oculopharyngeal muscular dystrophy (OPMD) is a hereditary neuromuscular disease with autosomal dominant and rarely with autosomal recessive inheritance types. (deepdyve.com)
- Facioscapulohumeral (FSH) muscular dystrophy is an autosomal dominant form that initially affects muscles of the face (facio), scapula (scapulo) and upper arms (humeral). (nih.gov)
- The standardization of operating procedures for cardiac research, and research involving cardiac assessment and monitoring in Duchenne animal models, hopes to improve the comparability of research studies performed in multiple laboratories. (parentprojectmd.org)
- Non-cardiac SOP's for Duchenne animal models are available on the TREAT-NMD website . (parentprojectmd.org)
- Using tracer molecules, we compared sarcolemmal integrity in animal models for muscular dystrophy and in muscular dystrophy patient samples. (rupress.org)
- To study altered sarcolemmal permeability in dystrophic muscle fibers, we injected animal models for muscular dystrophy with Evans blue dye (EBD). (rupress.org)
- Identified in nature or generated in laboratory, animal models are an important tool to study neuromuscular disorders. (nature.com)
- These results demonstrate the efficacy of gene replacement therapy for myotubular myopathy in animal models and pave the way to a clinical trial in patients. (medindia.net)
- The leading example is Duchenne muscular dystrophy (DMD), a fatal muscle degenerative disease, where AO-mediated skipping of specific DMD gene exons can restore the disrupted DMD open reading frame, leading to the production of functional dystrophin protein and ameliorate the DMD phenotype in animal models. (ox.ac.uk)
- Recently, a number of groups have demonstrated the promise of AOs directly conjugated to cell-penetrating peptides (CPPs) as having significant potential for systemic delivery and therapeutic correction in DMD animal models. (ox.ac.uk)
- Here, we review the background to this work and describe in detail the experimental protocols used in studies aimed at investigating CPP-conjugated AOs as systemic splice correcting agents in animal models of DMD. (ox.ac.uk)
- A few animal models of Duchenne muscular dystrophy (DMD) are available large ones such as pigs or dogs being expensive and difficult to handle. (livingseas.org)
- Nevertheless new animal models are needed to KLF4 help pre-clinical research on DMD. (livingseas.org)
- Can Animal Models of Disease Reliably Inform Human Studies? (semanticscholar.org)
- A methanolic extract of B. monniera possesses antidepressant-like activity in the animal behavioural models. (greenmedinfo.com)
- With their modified gene therapy approach, a multidisciplinary team from the Perelman School of Medicine at the University of Pennsylvania engineered adeno-associated virus (AAV) vectors to deliver a "substitute" protein for dystrophin in small and large animal DMD models to keep the muscles intact. (eurekalert.org)
- For the first time, we've shown how a carefully constructed version of a dystrophin-related protein can safely prevent the breakdown of muscle and maintain its function over time in the most informative animal models. (eurekalert.org)
- In two related studies published recently in online-before-print editions of Journal of the American Chemical Society and ACS Chemical Biology , the scientists show that these novel compounds significantly improve a number of biological defects associated with myotonic dystrophy type 1 in both cell culture and animal models. (scripps.edu)
- Our compounds attack the root cause of the disease and they improve defects in animal models," said Scripps Research Associate Professor Matthew Disney, PhD. "This represents a significant advance in rational design of compounds targeting RNA. (scripps.edu)
- In animal models, one of these compounds improved protein-splicing defects by more than 40 percent. (scripps.edu)
- This Review describes the promising biomarkers for dystrophic muscle that have been identified in muscle, mainly using animal models. (biologists.org)
- Developing robust biomarkers for a disease requires comprehensive information about the human condition and the associated animal models. (biologists.org)
- Musculoskeletal modeling therefore is an opportunity to gain insight into muscle functions within the mouse musculoskeletal system, which could be used to inform new and/or improved animal models of neuromuscular diseases. (frontiersin.org)
- Gene therapy in large animal models of muscular dystrophy. (semanticscholar.org)
- So Ares and Du teamed up with leading investigators of mytonic dystrophy who had developed animal models of the disease. (redorbit.com)
- This page serves as an index of all our scientific posts describing research which has used animal models. (speakingofresearch.com)
- DMD genes packaged into viral vectors strengthen muscles in mouse models of muscular dystrophy," said Jerry R. Mendell, MD , director, Center for Gene Therapy at The Research Institute at Nationwide Children's Hospital and one of the study authors. (nationwidechildrens.org)
- Zakia is a research associate in the lab of Dr Rolf Stottmann at Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA, investigating animal models that recapitulate a human condition for understanding disease pathogenesis. (medworm.com)
- In its most recent five-year plan , the agency stated that "animal models often fail to … predict how drugs will work in humans. (peta.org)
- β -sarcoglycan (A3b) mutations cause autosomal recessive muscular dystrophy with loss of the sarcoglycan complex," Nature Genetics , vol. 11, no. 3, pp. 266-273, 1995. (hindawi.com)
- β -Sarcoglycan: characterization and role in limb-girdle muscular dystrophy linked to 4q12," Nature Genetics , vol. 11, no. 3, pp. 257-265, 1995. (hindawi.com)
- Animal Genetics accepts buccal swab, blood, and dewclaw samples for testing. (horsetesting.com)
- Animal Genetics offers DNA testing for Muscular Dystrophy. (horsetesting.com)
Patients with myotonic dystrophy2
Causes myotonic dystrophy2
- By querying the database against the secondary structure of the triplet repeat that causes myotonic dystrophy type 1, a lead compound targeting this RNA was quickly identified. (scripps.edu)
- The first author of the ACS Chemical Biology study, "Rationally Designed Small Molecules Targeting the RNA That Causes Myotonic Dystrophy Type 1 Are Potently Bioactive" ( http://pubs.acs.org/doi/abs/10.1021/cb200408a ) is Jessica L. Childs-Disney of Scripps Research. (scripps.edu)
Mutations in the dystrophin gene2
- Duchenne muscular dystrophy is an inherited neuromuscular disorder primarily occurring in boys and caused by mutations in the dystrophin gene. (emaxhealth.com)
- Because many different mutations in the dystrophin gene can lead to muscular dystrophy, initially a CRISPR treatment wouldn't fix all of them. (technologyreview.com)
- Missense mutations in the adhalin gene linked to autosomal recessive muscular dystrophy," Cell , vol. 78, no. 4, pp. 625-633, 1994. (hindawi.com)
- Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disorder, which is caused by dystrophin deficiency in muscle fibers. (springer.com)
- The various DNA techniques focus on both the X-linked muscular dystrophies and the autosomal recessive muscular dystrophies. (springer.com)
- Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding dystrophin and four autosomal recessive subtypes of limb-girdle muscular dystrophy (LGMD) are caused by mutations in the sarcoglycans. (frontiersin.org)
- The mdx mouse develop an X-linked recessive muscular dystrophy (locus Xp21.1) and lack dystrophin expression. (scielo.br)
- Duchenne muscular dystrophy (DMD) is a lethal, X-linked disease that causes severe loss of muscle mass and function in young children. (biologists.org)
- CMD is a group of some 20 inherited muscular dystrophies characterized by progressive and severe muscle wasting and weakness first noticed soon after birth. (innovations-report.com)
- More devastating mutations in these same genes can cause severe childhood autosomal muscular dystrophy (SCARMD). (nih.gov)
- Facioscapulohumeral muscular dystrophy (FSHD) is a genetically dominant myopathy caused by mutations that disrupt repression of the normally silent DUX4 gene, which encodes a transcription factor that has been shown to interfere with myogenesis when misexpressed at very low levels in myoblasts and to cause cell death when overexpressed at high levels. (biologists.org)
- Researchers have found a delivery method for gene therapy that reaches all the voluntary muscles of a mouse - including heart, diaphragm and limbs - and reverses the process of muscle-wasting found in muscular dystrophy. (eurekalert.org)
- We have a clear 'proof of principle' that it is possible to deliver new genes body-wide to all the striated muscles of an adult animal. (eurekalert.org)
- Our new work identifies for the first time a method where a new dystrophin gene can be delivered, using a safe and simple method, to all of the affected muscles of a mouse with muscular dystrophy," said Dr. Jeffrey S. Chamberlain, professor of neurology and director of the Muscular Dystrophy Cooperative Research Center at the University of Washington School of Medicine in Seattle. (eurekalert.org)
- The meat you eat, if you're a carnivore, comes from animal muscles. (singularityhub.com)
- If the cardiac muscles are impaired the animal may exhibit signs of respiratory distress. (wikipedia.org)
- In calves, muscles in upper portion of the front legs and the hind legs are degraded, causing the animal to have a stiff gait and it may have difficulty standing. (wikipedia.org)
- Myotonic dystrophy involves difficulty relaxing muscles (myotonia) and, as in other muscular dystrophies, progressive muscle weakness and wasting. (redorbit.com)
- The degree of attack of the muscles seems to show a positive correlation with animal age. (vin.com)
- An immune reaction to dystrophin, the muscle protein that is defective in patients with Duchenne muscular dystrophy, may pose a new challenge to strengthening muscles of patients with this disease, suggests a new study appearing in the October 7, 2010, issue of The New England Journal of Medicine . (nationwidechildrens.org)
- Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy," Science , vol. 270, no. 5237, pp. 819-822, 1995. (hindawi.com)
- Absence of this protein causes a debilitating and incurable Duchenne muscular dystrophy. (port.ac.uk)
- In Muscular Dystrophy: Methods and Protocols, Katherine Bushby and Louise Anderson have assembled an outstanding collection of key techniques for the analysis of DNA and protein from patients suspected to suffer from muscular dystrophy. (springer.com)
- Duchenne muscular dystrophy (DMD) is a lethal X-linked neuromuscular disorder character-ized by progressive muscle degeneration due to lack of dystrophin, a protein essential for the integrity of sarcolemma during contraction. (unipg.it)
- Duchenne muscular dystrophy (DMD) is a lethal, X chromosome-linked muscle disease caused by mutations in the dystrophin ( DMD ) gene, which result in the loss or altered function of dystrophin protein. (biologists.org)
- In many instances, the genes and protein products responsible for the dystrophies have been identified and it is now possible to establish a precise diagnosis, detect preclinical cases, identify carriers and offer prenatal diagnostic testing. (oup.com)
- By uncovering a somewhat surprising T cell immune response to dystrophin, they're helping investigators refine several distinct and promising approaches to treating Duchenne muscular dystrophy (DMD) by correcting or adding the dystrophin protein that is defective in the disease. (nationwidechildrens.org)
- In myotonic dystrophy, a mutation causes RNA to bind to an important protein in the cell nucleus. (healthcanal.com)
- Muscular dystrophy refers to any of a group of disorders in which low levels of the protein dystrophin causes progressive muscle degeneration. (petcarerx.com)
- Chronic Inflammatory Demyelinating Polyneuropathy Guillain-Barre Syndrome Diseases of the Motor Neuron Amyotrophic Lateral Sclerosis Postpolio Syndrome Spinal Muscular Atrophy Other Diseases Involving the Spinal Cord Traumatic Injury Multiple Sclerosis with a particular focus on the diaphragm. (fitness-vip.com)
- Dietz's team then wondered whether the muscle improvement from blocking TGF-beta was specific to Marfan syndrome or possibly represented a strategy that could be applied to other muscle diseases such as Duchenne muscular dystrophy (DMD). (hopkinsmedicine.org)
- The term "muscular dystrophy" is used to refer to some 50 different diseases. (eurekalert.org)
- The implications of the pre-clinical findings are extraordinary for inherited muscular diseases," said Childers, co-senior author on the paper, and co-principal investigator of the study. (medicalxpress.com)
- Two, Editas and CRISPR Therapeutics, list muscular dystrophy among the diseases they are interested in, but it's not a top priority. (technologyreview.com)
- Scientists say that the research, while still in its early stages, could eventually lead to a cell-based therapy for patients with muscular dystrophy and other muscle-related diseases. (technologyreview.com)
- Phil Clifford is an NAIA board member who is waiting for animal rights advocates to solve some of the diseases that still plague mankind. (naiaonline.org)
- Cats also have several inherited diseases referred to as muscular dystrophy, although they are not necessarily the same as the one dogs get. (petcarerx.com)
- I am angry and disappointed that my money goes to obsolete animal experiments while millions of Americans live with debilitating diseases-people like my mother. (peta.org)
- Sustained AAV-mediated dystrophin expression in a canine model of Duchenne muscular dystrophy with a brief course of immunosuppression. (semanticscholar.org)
- Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study," The Lancet Neurology , vol. 8, no. 10, pp. 918-928, 2009. (hindawi.com)
- Canine X-linked muscular dystrophy. (vin.com)
- Last year, the Food and Drug Administration approved the first genetically modified animal for consumption , much to the chagrin of consumer and environmental groups who have been fighting to keep it from being approved for years. (takepart.com)
Myotonic Dystrophy Type4
- The first authors of the JACS study, "Design of a Bioactive Small Molecule that Targets the Myotonic Dystrophy Type 1 RNA via an RNA Motif-Ligand Database & Chemical Similarity Searching" ( http://pubs.acs.org/doi/abs/10.1021/ja210088v ), are Raman Parkesh and Jessica Childs-Disney of Scripps Research. (scripps.edu)
- Myotonic dystrophy type 1, called DM1 for short, is caused by a mutation to one gene. (innovations-report.com)
- The most common type of myotonic dystrophy (type 1) is caused by changes in a gene that has a repeating sequence of three DNA building blocks. (redorbit.com)
- A proof version of the paper, "A Novel CUGexp·MBNL1 Inhibitor With Therapeutic Potential for Myotonic Dystrophy Type 1," is available online . (healthcanal.com)
- A clinical trial of a gene therapy for Duchenne muscular dystrophy has been halted after a patient suffered serious side effects following treatment, Reuters reports today (November 12). (the-scientist.com)
- Both large and small animal species deficient for dystrophin have been described SB-505124 and have been extremely useful for pre-clinical studies of DMD. (livingseas.org)
- These results indicate that rats represent a new invaluable small animal model for pre-clinical research on DMD. (livingseas.org)
- These Centers promote collaborative basic, translational and clinical research and provide important resources that can be used by the national muscular dystrophy research communities. (nih.gov)
- Endpoint measures in the mdx mouse relevant for muscular dystrophy pre-clinical studies. (semanticscholar.org)
- We summarise data linked to myonecrosis in muscle, blood and urine of dystrophic animal species, and discuss the challenge of translating such biomarkers to the clinic for DMD patients, especially to enhance the success of clinical trials. (biologists.org)
- And if it works in animals, then we move hopefully into clinical trials with humans," Zimmerman said. (innovations-report.com)
- Dystrophic animals presented clinical signs such as weakness and muscular atrophy and serum creatine quinase (CK) high levels. (vin.com)
- In muscular dystrophies, however, a failure of the regenerative process results in muscle degeneration and weakness. (nature.com)
- Nutritional Muscular Dystrophy (Nutritional Myopathy or White Muscle Disease) is a disease caused by a deficiency of selenium and vitamin E in dietary intake. (wikipedia.org)
- These mutant animals appear very weak with shortened lifespans, similar to patients with myotubular myopathy. (medicalxpress.com)
- Marked histological alterations in the muscular tissues associated to myonecrosis and inflammatory mononuclear cell infiltrate (lymphocytes, monocytes/macrophages) suggest a participation of the immune system in this myopathy. (scielo.br)
- Cardiac care for these muscular dystrophies consists of management of symptoms with standard heart medications after detection of reduced whole heart function. (frontiersin.org)
- The symptoms of an individual with limb-girdle muscular dystrophy (LGMD) generally are great difficulty walking, going both up and down stairs, and rising from a chair. (wikipedia.org)
Common form of muscular1
- Detailed information on myotonic muscular dystrophy, a common form of muscular disease that affects adults and children. (medindia.net)
- The main benefit of this research is to cure human disease and improve function in humans and animals afflicted with neuromuscular disorders. (change.org)
- In: Milhorat A.T.: Exploratory concepts in muscular dystrophy and related disorders. (springer.com)
- The muscular dystrophies are an important group of inherited disorders. (oup.com)
- Muscular dystrophies are hereditary myopathies characterized by weakness and progressive muscular degeneration and consequently substitution for conjunctive and adipose tissue that can be appraised morphologically. (vin.com)
- Animal Model Small Group members included Dongsheng Duan (co-leader), Jill Rafael-Fortney (co-leader), Alison Blain, David Kass, Elizabeth McNally, Joseph Metzger, and Chris Spurney. (parentprojectmd.org)
- The available studies to date provide evidence of a role for NEMG as an in vivo, objective measurement tool to assess neuromuscular function without endangering the patient or requiring sacrifice of the animal model being studied. (elsevier.com)
- Although each animal model has its own limitations they have all been essential for the development of treatment strategies SB-505124 that target dystrophin absence disease progression or muscle regeneration . (livingseas.org)
- Rats possess a practical size being that they are 10 moments bigger than mouse but SB-505124 remain a small lab animal model and invite research with high statistical power. (livingseas.org)
- Monitoring disease activity noninvasively in the mdx model of Duchenne muscular dystrophy. (nih.gov)
- To determine whether this same early myocardial dysfunction is present in other muscular dystrophy cardiomyopathies, we conducted a physiological assessment of cardiac function at the tissue level in the δ-sarcoglycan null mouse model ( Sgcd −/− ) of Limb-girdle muscular dystrophy type 2F. (frontiersin.org)
- Virotherapy withclaudin-5 prevents the onset of cardiomyopathy in another muscular dystrophy model. (frontiersin.org)
- This in turn suggests that it is highly improbable that the mouse mdx locus represents a model for Duchenne muscular dystrophy (DMD). (biomedsearch.com)
- This defect also provides a unique biomedical model for human cardiomyopathy associated with muscular dystrophy that may be superior to those available because of the similarities in anatomy and physiology and allow advances in gene therapies for human disease. (biomedcentral.com)
- The mdx mouse is a popular model for studying Duchenne muscular dystrophy (DMD). (wikipedia.org)
- An animal model of Duchenne muscular dystrophy: morphologic lesions. (vin.com)
- Generation of a new animal model for human LCAT deficiency. (usda.gov)
- In this study we attempted to translate basic research from the animal model to patients with DMD. (nationwidechildrens.org)
- By using a miniature gene, similar in function to the one defective in CMD, and applying a newly developed method for "systemic" gene delivery, the Pitt researchers have shown that gene therapy for muscular dystrophy is both feasible and effective in a mouse model of especially profound disease. (innovations-report.com)
- Duchenne muscular dystrophy (DMD) is a hereditary and lethal neuromuscular disease characterized by progressive loss of muscle strength and integrity. (nationwidechildrens.org)
- Patients with muscular dystrophy lack dystrophin. (technologyreview.com)
- Chamberlain and colleagues in the Muscular Dystrophy Cooperative Research Center are gathering data to seek regulatory approval for a limited trial in humans to determine the safety of a very small amount of the vector in human muscle. (eurekalert.org)
- The research was funded by grants from the National Institutes of Health, the Muscular Dystrophy Association, and Bruce and Jolene McCaw. (eurekalert.org)
- The research at Texas A&M and other universities has resulted in meaningful progress toward treatment and possibly curing this disease in both humans and animals. (change.org)
- The Institute of Animal Care and Use Committee (IACUC) - similar to IRB for human research - is a federally mandated review board required for all animal research. (change.org)
- The IACUC has rigid standards to protect the welfare of animals used in research. (change.org)
- Many animal research projects do not have veterinarians on the research team, only as consultants. (change.org)
- PETA is active at all of the campuses where this research is taking place, as well as most every facility where ANY animal research is taking place, including the DoD. (change.org)
- The team's success at manipulating P2X7 and their plans for further research have received strong endorsement from a panel of the world's leading experts in muscular dystrophy. (port.ac.uk)
- Comprehensive and highly practical, Muscular Dystrophy: Methods and Protocols offers today‚s diagnostic laboratories, basic and medical researchers, and active clinicians an authoritative collection of tools that will serve as exacting diagnostic tools as well as greatly empowering research on the novel therapeutics now beginning to emerge. (springer.com)
- Materials and Methods Animals This study was approved by the Ethics Committee on Animal SB-505124 Experimentation of the Pays de la Loire Region France in accordance with the guidelines from your French National Research Council SB-505124 for the Care and Use of Laboratory Animals (Permit Figures: CEEA-PdL-2011-45 and CEEA-PdL-01579.01). (livingseas.org)
- Notice of Intent to Publish a Funding Opportunity Announcement (FOA) for the Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers (U54). (nih.gov)
- The purpose of this Funding Opportunity Announcement (FOA) is to publicize the re-competition of Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers (MDCRCs). (nih.gov)
- The centers also provide an outstanding environment for the training and career development of new scientists electing to pursue careers conducting research in high priority areas of muscular dystrophy. (nih.gov)
- The Muscular Dystrophy Community Assistance, Research, and Education Amendments of 2001 (the MD-CARE Act, Public Law 107-84) specified a number of provisions for expanding and intensifying research on muscular dystrophy. (nih.gov)
- One provision of the MD-CARE Act was that the NIH establish centers of excellence for research on muscular dystrophy. (nih.gov)
- The MDCRCs program was subsequently developed in honor of Senator Paul D. Wellstone, a champion of muscular dystrophy research. (nih.gov)
- As the statistics on the use of animals for research in 2013 have been released today, we thought it would be nice to look back on the impressive research published last year. (understandinganimalresearch.org.uk)
- In: Angelini C., Danieli G.A., Fontanari D.: Muscular Dystrophy Research. (springer.com)
- But now scientists from the Florida campus of The Scripps Research Institute have for the first time designed a series of small molecules that act against an RNA defect directly responsible for the most common form of adult-onset muscular dystrophy. (scripps.edu)
- This study was supported by the National Institutes of Health, the Muscular Dystrophy Association, Scripps Research, the Camille & Henry Dreyfus Foundation, and the Research Corporation for Science Advancement. (scripps.edu)
- In the U.S. Meat Animal Research Center's swine research population, a novel stress syndrome was detected. (biomedcentral.com)
- MDA has had an important impact on research in muscular dystrophy," Zolt said. (mda.org)
- MDA has had an important impact on research in muscle dystrophy, and its role now, in times of federal budgetary constraints, is more critical and influential than ever. (mda.org)
- In the letter, Sixx points out that because 37 years of these misguided tests - for which dogs are caged, often alone, in barren metal cells - have failed to produce a cure or even a treatment for the disease in humans, TAMU should admit defeat and redirect its resources into modern, humane, animal-free research methods that could actually generate results. (blabbermouth.net)
- Why is alcohol research with nonhuman animals essential? (speakingofresearch.com)
- The following chart compares the benefits provided by medical research with animals and efforts of animal rights activists. (naiaonline.org)
- With one safety trial involving six patients, Drs. Mendell and Walker have provided a tremendous service to scientists advancing gene therapy research - particularly for muscular dystrophy,' said Louis M. Kunkel, Ph.D., chairman of the Muscular Dystrophy Association (MDA) Scientific Advisory Committee. (nationwidechildrens.org)
- The New England Aquarium is a catalyst for global change through public engagement, commitment to marine animal conservation, leadership in education, innovative scientific research, and effective advocacy for vital and vibrant oceans. (donateacar.com)
- Because in the future I hope to become muscular and shredded, I figured that I am going to have to inevitably study this material, so why not study it as part of my research project. (bartleby.com)
- Your mother is in the intensive care unit, dying of a disease without a cure, and your country's top research agency is wasting billions of dollars on ineffective animal tests instead of funding research that will help her. (peta.org)
- How are scientists supposed to solve a mystery when funding goes to animal experiments and not research that would lead to actual advancements? (peta.org)
- We need modern research, not antiquated tests on animals. (peta.org)
- Put simply, we need animal-free research, now. (peta.org)
- So little animal research results in anything beneficial to humans," said the late Dr. Tom Poulton. (peta.org)
- He was diagnosed with a rare neurological disorder but didn't want to turn to animal research. (peta.org)
- The Farm currently houses about 100 dogs undergoing experiments for research on muscular dystrophy. (indyweek.com)